--- OA_place: publisher _id: '20206' abstract: - lang: eng text: "The internal structure of biomolecules and their organization in higher-order arrangements are key factors governing the working principles of biological systems. Bioimaging has successfully revealed arrangements across relevant spatial scales. For example, cryo-electron tomography has become widely used for analyzing biomolecular structures in situ due to its comprehensive structural visualization of near-natively preserved samples, and its capability of sub-nm resolution via averaging. However, the identification of molecules within crowded cellular environments is often hindered by low contrast. Fluorescence microscopy, on the other hand, routinely visualizes specifically labeled targets at single-molecule contrast against essentially zero background. Moreover, it provides comparatively high throughput and is amenable to multiplexing. Due to this complementarity, combining datasets from both modalities acquired on the same region via correlative light and electron microscopy can reveal novel types of information. \r\nThe spatial scale at which information can be extracted depends on imaging resolution and correlation accuracy. Since diffraction of light limits the resolution of conventional fluorescence microscopy to few hundreds of nanometers, reaching the full potential of correlative imaging requires super-resolution approaches. Performing imaging at cryogenic temperature preserves structures in a near-native state and minimizes distortions between the fluorescence and the electron microscopy datasets. Implementations of this concept have achieved correlation on the scale of cellular organelles or bacterial domains.\r\nWe have worked towards pushing correlative imaging to the single-molecule scale by improving cryo-super-resolution microscopy, and devising a refined image correlation workflow. As part of this project, I constructed a microscopy setup and adopted it for super-resolution fluorescence microscopy at room temperature and cryogenic conditions. I explored different cryo-stages and acquisition strategies. Specifically, I developed a new scheme for correcting sample drift, thus increasing mechanical stability during microscopy acquisitions.\r\n" acknowledged_ssus: - _id: M-Shop - _id: EM-Fac - _id: Bio acknowledgement: "The project was supported by CZI grant DAF2021-234754 and grant\r\nDOI: https://doi.org/10.37921/812628ebpcwg from the Chan Zuckerberg Initiative DAF, an\r\nadvised fund of Silicon Valley Community Foundation (funder\r\nDOI: https://doi.org/10.13039/100014989), as well as internal grants from ISTA’s Equipment\r\nInvestment Committee and Interdisciplinary Project Committee. " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 citation: ama: Vorlaufer J. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. 2025. doi:10.15479/AT-ISTA-20206 apa: Vorlaufer, J. (2025). Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20206 chicago: Vorlaufer, Jakob. “Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20206. ieee: J. Vorlaufer, “Construction of a cryo-super-resolution microscope to guide in situ structure analysis,” Institute of Science and Technology Austria, 2025. ista: Vorlaufer J. 2025. Construction of a cryo-super-resolution microscope to guide in situ structure analysis. Institute of Science and Technology Austria. mla: Vorlaufer, Jakob. Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20206. short: J. Vorlaufer, Construction of a Cryo-Super-Resolution Microscope to Guide in Situ Structure Analysis, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-22T08:12:55Z date_published: 2025-08-25T00:00:00Z date_updated: 2026-04-07T11:48:07Z day: '25' ddc: - '621' - '535' degree_awarded: PhD department: - _id: GradSch - _id: JoDa doi: 10.15479/AT-ISTA-20206 file: - access_level: closed checksum: 191db3367c19c9b32b65f4bc3a7c19de content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: jvorlauf date_created: 2025-08-25T13:49:55Z date_updated: 2025-08-25T13:49:55Z file_id: '20228' file_name: 2025_Vorlaufer_Jakob_Thesis.docx file_size: 39735535 relation: source_file - access_level: open_access checksum: 104400e6036921569610230c1d4899dc content_type: application/pdf creator: jvorlauf date_created: 2025-08-25T13:49:56Z date_updated: 2025-08-25T13:49:56Z file_id: '20229' file_name: 2025_Vorlaufer_Jakob_Thesis.pdf file_size: 10947446 relation: main_file success: 1 file_date_updated: 2025-08-25T13:49:56Z has_accepted_license: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '08' oa: 1 oa_version: Published Version page: '107' project: - _id: 62909c6f-2b32-11ec-9570-e1476aab5308 grant_number: CZI01 name: CryoMinflux-guided in-situ molecular census and structure determination publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '19795' relation: part_of_dissertation status: public status: public supervisor: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 title: Construction of a cryo-super-resolution microscope to guide in situ structure analysis tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher _id: '20212' acknowledged_ssus: - _id: Bio - _id: PreCl acknowledgement: "I would also like to\r\nthank the Austrian Academy of Sciences for awarding me a 2-year DOC fellowship\r\n(DOC26253)." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Osvaldo full_name: Miranda, Osvaldo id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425 last_name: Miranda orcid: 0000-0001-6618-6889 citation: ama: Miranda O. Unraveling the role of Pten in cortical stem cell lineage progression using MADM. 2025. doi:10.15479/AT-ISTA-20212 apa: Miranda, O. (2025). Unraveling the role of Pten in cortical stem cell lineage progression using MADM. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20212 chicago: Miranda, Osvaldo. “Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20212. ieee: O. Miranda, “Unraveling the role of Pten in cortical stem cell lineage progression using MADM,” Institute of Science and Technology Austria, 2025. ista: Miranda O. 2025. Unraveling the role of Pten in cortical stem cell lineage progression using MADM. Institute of Science and Technology Austria. mla: Miranda, Osvaldo. Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20212. short: O. Miranda, Unraveling the Role of Pten in Cortical Stem Cell Lineage Progression Using MADM, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-22T14:07:00Z date_published: 2025-08-22T00:00:00Z date_updated: 2026-04-14T08:16:57Z day: '22' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: SiHi doi: 10.15479/AT-ISTA-20212 file: - access_level: closed checksum: 3331f76bbef74ff4908e2d2c9262045c content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: omiranda date_created: 2025-08-26T09:03:50Z date_updated: 2025-08-26T09:03:50Z file_id: '20230' file_name: 2025_MirandaRomero_OsvaldoAntonio_Thesis.docx file_size: 32887334 relation: source_file - access_level: closed checksum: 02509d50cff8e35c5bcbf71e8d658176 content_type: application/pdf creator: omiranda date_created: 2025-08-26T09:05:55Z date_updated: 2025-08-26T10:43:30Z embargo: 2026-08-26 embargo_to: open_access file_id: '20231' file_name: 2025_MirandaRomero_OsvaldoAntonio_Thesis.pdf file_size: 28636240 relation: main_file file_date_updated: 2025-08-26T10:43:30Z has_accepted_license: '1' keyword: - Pten - mtor - cortical development - MADM - Mapk language: - iso: eng month: '08' oa_version: Published Version page: '119' project: - _id: 34c9fbcb-11ca-11ed-8bc3-98fa5658610d grant_number: '26253' name: Molecular Mechanisms Regulating Cortical Neural Stem Cell Lineage Progression and Astrocyte Development publication_identifier: isbn: - 978-3-99078-063-3 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '17425' relation: part_of_dissertation status: public status: public supervisor: - first_name: Simon full_name: Hippenmeyer, Simon id: 37B36620-F248-11E8-B48F-1D18A9856A87 last_name: Hippenmeyer orcid: 0000-0003-2279-1061 title: Unraveling the role of Pten in cortical stem cell lineage progression using MADM type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20217' abstract: - lang: eng text: "We present Virgil, a Mid-Infrared Instrument (MIRI) extremely red object detected with the F1000W filter as part of the MIRI Deep Imaging Survey observations of the Hubble Ultra Deep Field. Virgil is an Lyα emitter (LAE) at zspec = 6.6312 ± 0.0019 (from the Very Large Telescope/MUSE) with a rest-frame UV-to-optical spectral energy distribution (SED) typical of LAEs at similar redshifts. However, MIRI observations reveal an unexpected extremely red color at rest-frame near-infrared (NIR) wavelengths, F444W − F1000W = 2.33 ± 0.06. Such a steep\r\nrise in the NIR, completely missed without MIRI imaging, is poorly reproduced by models including only stellar populations and hints toward the presence of an active galactic nucleus, although alternative explanations such as extreme dust obscuration and strong nebular continuum and emission lines contribution due to young stellar ages cannot be completely ruled out. According to the shape of its overall SED, Virgil belongs to the recently discovered\r\npopulation of little red dots but displays an extended rest-frame UV-optical wavelength morphology following a 2DSérsic profile with an average index of n = 0.93+0.85_0.31 and re = 0.49+0.05_0.11 pkpc. Only at MIRI wavelengths, Virgil is unresolved due to the coarser point-spread function. This discovery demonstrates the crucial importance of deep MIRI surveys to reveal the true nature and properties of high-z galaxies that otherwise would be misinterpreted and raises the question of how common Virgil-like objects could be in the early Universe." acknowledgement: "The authors thank R. Cooper, G. Yang, V. Kokorev, D. Wen, C. Williams, and H. Übler for useful discussions and comments.\r\nE.I. and K.I.C. acknowledge funding from the Netherlands Research School for Astronomy (NOVA). K.I.C. acknowledges funding from the Dutch Research Council (NWO) through the award of the Vici grant VI.C.212.036. A.A.-H. acknowledges support from grant PID2021-124665NB-I00 funded by MCIN/AEI/10.13039/ 501100011033 and by “ERDF A way of making Europe.” P.G.P.-G. acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, FEDER Una manera de hacer Europa. J.A.-M., A.C.-G., and L.C. acknowledge support by grant PIB2021-127718NB-100 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” L.C. thanks the support from the Cosmic Dawn Center received during visits to DAWN as an international associate. L.C. acknowledges support by grants PIB2021-127718NB-100 and PID2022-139567NB-I00 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.” T.R.G. acknowledges support from the Carlsberg Foundation (grant No. CF20-0534). S.G. acknowledges financial support from the Cosmic Dawn Center (DAWN), funded by the Danish National Research Foundation (DNRF) under grant No. 140. This work was supported by research grants (VIL16599, VIL54489) from VILLUM FONDEN. J.P.P. and T.V.T. acknowledge financial support from the UK Science and Technology Facilities Council and the UK Space Agency.\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the MAST at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs GO #1963, GO #1895, and GTO #1283. The authors acknowledge the team led by co-PIs: C. Williams, M. Maseda, and S. Tacchella, and PI P. Oesch, for developing their respective observing programs with a zero-exclusive-access period. Also based on observations made with the NASA/ESA HST obtained from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. The work presented here is the effort of the entire MIRI team, and the enthusiasm within the MIRI partnership is a significant factor in its success. MIRI draws on the scientific and technical expertise of the following organizations: Ames Research Center, USA; Airbus Defence and Space, UK; CEA-Irfu, Saclay, France; Centre Spatial de Liège, Belgium; Consejo Superior de Investigaciones Científicas, Spain; Carl Zeiss Optronics, Germany; Chalmers University of Technology, Sweden; Danish Space Research Institute, Denmark; Dublin Institute for Advanced Studies, Ireland; European Space Agency, Netherlands; ETCA, Belgium; ETH Zurich, Switzerland; Goddard Space Flight Center, USA; Institute d’Astrophysique Spatiale, France; Instituto Nacional de Técnica Aeroespacial, Spain; Institute for Astronomy, Edinburgh, UK; Jet Propulsion Laboratory, USA; Laboratoire d’Astrophysique de Marseille (LAM), France; Leiden University, Netherlands; Lockheed Advanced Technology Center (USA); NOVA Opt-IR group at Dwingeloo, Netherlands; Northrop Grumman, USA; Max-Planck Institut für Astronomie (MPIA), Heidelberg, Germany; Laboratoire d’Etudes Spatiales et d’Instrumentation en Astrophysique (LESIA), France; Paul Scherrer Institut, Switzerland; Raytheon Vision Systems, USA; RUAG Aerospace, Switzerland; Rutherford Appleton Laboratory (RAL Space), UK; Space Telescope Science Institute, USA; Toegepast-Natuurwetenschappelijk Onderzoek (TNO-TPD), Netherlands; UK Astronomy Technology Centre, UK; University College London, UK; University of Amsterdam, Netherlands; University of Arizona, USA; University of Cardiff, UK; University of Cologne, Germany; University of Ghent; University of Groningen, Netherlands; University of Leicester, UK; University of Leuven, Belgium; University of Stockholm, Sweden; Utah State University, USA.\r\nFor the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to the Author Accepted Manuscript version arising from this submission." article_number: '160' article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Edoardo full_name: Iani, Edoardo id: 4053390a-6b68-11ef-9828-a3b8adef8d0a last_name: Iani orcid: 0000-0001-8386-3546 - first_name: Pierluigi full_name: Rinaldi, Pierluigi last_name: Rinaldi - first_name: Karina I. full_name: Caputi, Karina I. last_name: Caputi - first_name: Marianna full_name: Annunziatella, Marianna last_name: Annunziatella - first_name: Danial full_name: Langeroodi, Danial last_name: Langeroodi - first_name: Jens full_name: Melinder, Jens last_name: Melinder - first_name: Pablo G. full_name: Pérez-González, Pablo G. last_name: Pérez-González - first_name: Javier full_name: Álvarez-Márquez, Javier last_name: Álvarez-Márquez - first_name: Leindert A. full_name: Boogaard, Leindert A. last_name: Boogaard - first_name: Sarah E.I. full_name: Bosman, Sarah E.I. last_name: Bosman - first_name: Luca full_name: Costantin, Luca last_name: Costantin - first_name: Thibaud full_name: Moutard, Thibaud last_name: Moutard - first_name: Luis full_name: Colina, Luis last_name: Colina - first_name: Göran full_name: Östlin, Göran last_name: Östlin - first_name: Thomas R. full_name: Greve, Thomas R. last_name: Greve - first_name: Gillian full_name: Wright, Gillian last_name: Wright - first_name: Almudena full_name: Alonso-Herrero, Almudena last_name: Alonso-Herrero - first_name: Arjan full_name: Bik, Arjan last_name: Bik - first_name: Steven full_name: Gillman, Steven last_name: Gillman - first_name: Alejandro full_name: Crespo Gómez, Alejandro last_name: Crespo Gómez - first_name: Jens full_name: Hjorth, Jens last_name: Hjorth - first_name: Sarah full_name: Kendrew, Sarah last_name: Kendrew - first_name: Alvaro full_name: Labiano, Alvaro last_name: Labiano - first_name: John P. full_name: Pye, John P. last_name: Pye - first_name: Tuomo V. full_name: Tikkanen, Tuomo V. last_name: Tikkanen - first_name: Fabian full_name: Walter, Fabian last_name: Walter - first_name: Manuel full_name: Güdel, Manuel last_name: Güdel - first_name: Thomas full_name: Henning, Thomas last_name: Henning - first_name: Paul P. full_name: Van Der Werf, Paul P. last_name: Van Der Werf citation: ama: 'Iani E, Rinaldi P, Caputi KI, et al. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. 2025;989(2). doi:10.3847/1538-4357/ade5a6' apa: 'Iani, E., Rinaldi, P., Caputi, K. I., Annunziatella, M., Langeroodi, D., Melinder, J., … Van Der Werf, P. P. (2025). MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ade5a6' chicago: 'Iani, Edoardo, Pierluigi Rinaldi, Karina I. Caputi, Marianna Annunziatella, Danial Langeroodi, Jens Melinder, Pablo G. Pérez-González, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” The Astrophysical Journal. IOP Publishing, 2025. https://doi.org/10.3847/1538-4357/ade5a6.' ieee: 'E. Iani et al., “MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6,” The Astrophysical Journal, vol. 989, no. 2. IOP Publishing, 2025.' ista: 'Iani E, Rinaldi P, Caputi KI, Annunziatella M, Langeroodi D, Melinder J, Pérez-González PG, Álvarez-Márquez J, Boogaard LA, Bosman SEI, Costantin L, Moutard T, Colina L, Östlin G, Greve TR, Wright G, Alonso-Herrero A, Bik A, Gillman S, Crespo Gómez A, Hjorth J, Kendrew S, Labiano A, Pye JP, Tikkanen TV, Walter F, Güdel M, Henning T, Van Der Werf PP. 2025. MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6. The Astrophysical Journal. 989(2), 160.' mla: 'Iani, Edoardo, et al. “MIDIS: MIRI Uncovers Virgil, the First Little Red Dot with Clear Detection of Its Host Galaxy at z ≃ 6.6.” The Astrophysical Journal, vol. 989, no. 2, 160, IOP Publishing, 2025, doi:10.3847/1538-4357/ade5a6.' short: E. Iani, P. Rinaldi, K.I. Caputi, M. Annunziatella, D. Langeroodi, J. Melinder, P.G. Pérez-González, J. Álvarez-Márquez, L.A. Boogaard, S.E.I. Bosman, L. Costantin, T. Moutard, L. Colina, G. Östlin, T.R. Greve, G. Wright, A. Alonso-Herrero, A. Bik, S. Gillman, A. Crespo Gómez, J. Hjorth, S. Kendrew, A. Labiano, J.P. Pye, T.V. Tikkanen, F. Walter, M. Güdel, T. Henning, P.P. Van Der Werf, The Astrophysical Journal 989 (2025). date_created: 2025-08-24T22:01:29Z date_published: 2025-08-20T00:00:00Z date_updated: 2026-02-16T12:43:12Z day: '20' ddc: - '520' department: - _id: JoMa doi: 10.3847/1538-4357/ade5a6 external_id: arxiv: - '2406.18207' isi: - '001548132000001' file: - access_level: open_access checksum: 92196e8352dddb1f305c253da1996ab6 content_type: application/pdf creator: dernst date_created: 2025-09-02T06:40:23Z date_updated: 2025-09-02T06:40:23Z file_id: '20268' file_name: 2025_AstrophysicalJour_Iani.pdf file_size: 5474992 relation: main_file success: 1 file_date_updated: 2025-09-02T06:40:23Z has_accepted_license: '1' intvolume: ' 989' isi: 1 issue: '2' language: - iso: eng month: '08' oa: 1 oa_version: Published Version publication: The Astrophysical Journal publication_identifier: eissn: - 1538-4357 issn: - 0004-637X publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: 'MIDIS: MIRI uncovers Virgil, the first Little Red Dot with clear detection of its host galaxy at z ≃ 6.6' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 989 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20218' abstract: - lang: eng text: Humanity has long sought inspiration from nature to innovate materials and devices. As science advances, nature-inspired materials are becoming part of our lives. Animate materials, characterized by their activity, adaptability, and autonomy, emulate properties of living systems. While only biological materials fully embody these principles, artificial versions are advancing rapidly, promising transformative impacts in the circular economy, health and climate resilience within a generation. This roadmap presents authoritative perspectives on animate materials across different disciplines and scales, highlighting their interdisciplinary nature and potential applications in diverse fields including nanotechnology, robotics and the built environment. It underscores the need for concerted efforts to address shared challenges such as complexity management, scalability, evolvability, interdisciplinary collaboration, and ethical and environmental considerations. The framework defined by classifying materials based on their level of animacy can guide this emerging field to encourage cooperation and responsible development. By unravelling the mysteries of living matter and leveraging its principles, we can design materials and systems that will transform our world in a more sustainable manner. acknowledgement: "Living Architecture is Funded by the EU Horizon 2020 Future Emerging Technologies Open programme (2016–2019) Grant Agreement 686585 a consortium of 6 collaborating institutions—Newcastle University, University of Trento, University of the West of England, Spanish National Research Council, Explora Biotech and Liquifer Systems Group.\r\n\r\nThe Active Living Infrastructure: Controlled Environment (ALICE) project is funded by an EU Innovation Award for the development of a bio-digital ‘brick’ prototype, a collaboration between Newcastle University, Translating Nature, and the University of the West of England (2019–2021) under EU Grant Agreement No. 851246.\r\n\r\nMicrobial Hydroponics: Circular Sustainable Electrobiosynthesis (Mi-Hy) is Funded by the European Union under Grant Agreement Number 101114746, which is a collaboration between Beneficiaries, KU Leuven (Belgium), the University of Southampton (UK), SONY Computer Science Laboratory (France), BioFaction KG (Austria), Spanish National Research Council (Spain), and Associated Partners, the University of the West of England (UK) and University of Southampton (UK). Mi-Hy is also supported through the interdisciplinary KU Leuven Institute for Cultural Heritage (HERKUL)." article_number: '333501' article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: Giorgio full_name: Volpe, Giorgio last_name: Volpe - first_name: Nuno A.M. full_name: Araújo, Nuno A.M. last_name: Araújo - first_name: Maria full_name: Guix, Maria last_name: Guix - first_name: Mark full_name: Miodownik, Mark last_name: Miodownik - first_name: Nicolas full_name: Martin, Nicolas last_name: Martin - first_name: Laura full_name: Alvarez, Laura last_name: Alvarez - first_name: Juliane full_name: Simmchen, Juliane last_name: Simmchen - first_name: Roberto Di full_name: Leonardo, Roberto Di last_name: Leonardo - first_name: Nicola full_name: Pellicciotta, Nicola last_name: Pellicciotta - first_name: Quentin full_name: Martinet, Quentin id: b37485a8-d343-11eb-a0e9-df8c484ef8ab last_name: Martinet orcid: 0000-0002-2916-6632 - first_name: Jérémie A full_name: Palacci, Jérémie A id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d last_name: Palacci orcid: 0000-0002-7253-9465 - first_name: Wai Kit full_name: Ng, Wai Kit last_name: Ng - first_name: Dhruv full_name: Saxena, Dhruv last_name: Saxena - first_name: Riccardo full_name: Sapienza, Riccardo last_name: Sapienza - first_name: Sara full_name: Nadine, Sara last_name: Nadine - first_name: João F. full_name: Mano, João F. last_name: Mano - first_name: Reza full_name: Mahdavi, Reza last_name: Mahdavi - first_name: Caroline full_name: Beck Adiels, Caroline last_name: Beck Adiels - first_name: Joe full_name: Forth, Joe last_name: Forth - first_name: Christian full_name: Santangelo, Christian last_name: Santangelo - first_name: Stefano full_name: Palagi, Stefano last_name: Palagi - first_name: Ji Min full_name: Seok, Ji Min last_name: Seok - first_name: Victoria A. full_name: Webster-Wood, Victoria A. last_name: Webster-Wood - first_name: Shuhong full_name: Wang, Shuhong last_name: Wang - first_name: Lining full_name: Yao, Lining last_name: Yao - first_name: Amirreza full_name: Aghakhani, Amirreza last_name: Aghakhani - first_name: Thomas full_name: Barois, Thomas last_name: Barois - first_name: Hamid full_name: Kellay, Hamid last_name: Kellay - first_name: Corentin full_name: Coulais, Corentin last_name: Coulais - first_name: Martin full_name: Van Hecke, Martin last_name: Van Hecke - first_name: Christopher J. full_name: Pierce, Christopher J. last_name: Pierce - first_name: Tianyu full_name: Wang, Tianyu last_name: Wang - first_name: Baxi full_name: Chong, Baxi last_name: Chong - first_name: Daniel I. full_name: Goldman, Daniel I. last_name: Goldman - first_name: Andreagiovanni full_name: Reina, Andreagiovanni last_name: Reina - first_name: Vito full_name: Trianni, Vito last_name: Trianni - first_name: Giovanni full_name: Volpe, Giovanni last_name: Volpe - first_name: Richard full_name: Beckett, Richard last_name: Beckett - first_name: Sean P. full_name: Nair, Sean P. last_name: Nair - first_name: Rachel full_name: Armstrong, Rachel last_name: Armstrong citation: ama: Volpe G, Araújo NAM, Guix M, et al. Roadmap for animate matter. Journal of Physics Condensed Matter. 2025;37(33). doi:10.1088/1361-648X/adebd3 apa: Volpe, G., Araújo, N. A. M., Guix, M., Miodownik, M., Martin, N., Alvarez, L., … Armstrong, R. (2025). Roadmap for animate matter. Journal of Physics Condensed Matter. IOP Publishing. https://doi.org/10.1088/1361-648X/adebd3 chicago: Volpe, Giorgio, Nuno A.M. Araújo, Maria Guix, Mark Miodownik, Nicolas Martin, Laura Alvarez, Juliane Simmchen, et al. “Roadmap for Animate Matter.” Journal of Physics Condensed Matter. IOP Publishing, 2025. https://doi.org/10.1088/1361-648X/adebd3. ieee: G. Volpe et al., “Roadmap for animate matter,” Journal of Physics Condensed Matter, vol. 37, no. 33. IOP Publishing, 2025. ista: Volpe G, Araújo NAM, Guix M, Miodownik M, Martin N, Alvarez L, Simmchen J, Leonardo RD, Pellicciotta N, Martinet Q, Palacci JA, Ng WK, Saxena D, Sapienza R, Nadine S, Mano JF, Mahdavi R, Beck Adiels C, Forth J, Santangelo C, Palagi S, Seok JM, Webster-Wood VA, Wang S, Yao L, Aghakhani A, Barois T, Kellay H, Coulais C, Van Hecke M, Pierce CJ, Wang T, Chong B, Goldman DI, Reina A, Trianni V, Volpe G, Beckett R, Nair SP, Armstrong R. 2025. Roadmap for animate matter. Journal of Physics Condensed Matter. 37(33), 333501. mla: Volpe, Giorgio, et al. “Roadmap for Animate Matter.” Journal of Physics Condensed Matter, vol. 37, no. 33, 333501, IOP Publishing, 2025, doi:10.1088/1361-648X/adebd3. short: G. Volpe, N.A.M. Araújo, M. Guix, M. Miodownik, N. Martin, L. Alvarez, J. Simmchen, R.D. Leonardo, N. Pellicciotta, Q. Martinet, J.A. Palacci, W.K. Ng, D. Saxena, R. Sapienza, S. Nadine, J.F. Mano, R. Mahdavi, C. Beck Adiels, J. Forth, C. Santangelo, S. Palagi, J.M. Seok, V.A. Webster-Wood, S. Wang, L. Yao, A. Aghakhani, T. Barois, H. Kellay, C. Coulais, M. Van Hecke, C.J. Pierce, T. Wang, B. Chong, D.I. Goldman, A. Reina, V. Trianni, G. Volpe, R. Beckett, S.P. Nair, R. Armstrong, Journal of Physics Condensed Matter 37 (2025). date_created: 2025-08-24T22:01:30Z date_published: 2025-08-18T00:00:00Z date_updated: 2025-09-30T14:25:12Z day: '18' ddc: - '530' department: - _id: JePa doi: 10.1088/1361-648X/adebd3 external_id: arxiv: - '2407.10623' isi: - '001550090200001' file: - access_level: open_access checksum: 7309274f78bed785b158bd290337f456 content_type: application/pdf creator: dernst date_created: 2025-09-02T07:22:48Z date_updated: 2025-09-02T07:22:48Z file_id: '20271' file_name: 2025_CondensedMatter_Volpe.pdf file_size: 8997829 relation: main_file success: 1 file_date_updated: 2025-09-02T07:22:48Z has_accepted_license: '1' intvolume: ' 37' isi: 1 issue: '33' language: - iso: eng month: '08' oa: 1 oa_version: Published Version publication: Journal of Physics Condensed Matter publication_identifier: eissn: - 1361-648X issn: - 0953-8984 publication_status: published publisher: IOP Publishing quality_controlled: '1' scopus_import: '1' status: public title: Roadmap for animate matter tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 37 year: '2025' ... --- OA_type: closed access _id: '20219' abstract: - lang: eng text: Reproduction is a fundamental biological process, with organisms reproducing sexually, asexually, and, in some cases, utilizing both modes of reproduction within the same population. Does the ability to reproduce through a combination of asexual and sexual modes offer an evolutionary advantage over relying on either mode alone? Here, we introduce an empirically driven theoretical model to examine the dynamics and interplay between sexual and asexual reproduction in stick insect populations. We analyse it using a novel phase transition approach and corroborate it using published experimental data. We find that the presence of males can either increase or decrease the overall population size. However, maintaining an optimal ratio of parthenogenetic to sexual reproduction is crucial for male resilience, effectively delaying male extinction. Conversely, extreme levels of parthenogenetic reproduction—whether too high or too low—can lead to male extinction, emphasizing the need for a balanced number of virgin females to ensure the persistence of males. Our model also explains male absence in Carausius morosus and persistence in Extatosoma tiaratum. Our findings provide valuable insights into the interplay of reproductive strategies and contribute to broader discussions on the transitions between sexual and asexual reproduction. acknowledgement: We acknowledge Prof. Uri Alon for introducing us to the topic of systems biology during the graduate course at the Weizmann Institute of Science, whose insights and teachings have greatly inspired this work. article_number: '20250202' article_processing_charge: No article_type: original author: - first_name: Oran full_name: Ayalon, Oran last_name: Ayalon - first_name: Harikrishnan full_name: Rajendran, Harikrishnan id: 876b6b34-8ff4-11ec-97c9-8d95a7aae416 last_name: Rajendran citation: ama: Ayalon O, Rajendran H. Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. 2025;22(229). doi:10.1098/rsif.2025.0202 apa: Ayalon, O., & Rajendran, H. (2025). Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. The Royal Society. https://doi.org/10.1098/rsif.2025.0202 chicago: Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” Journal of the Royal Society Interface. The Royal Society, 2025. https://doi.org/10.1098/rsif.2025.0202. ieee: O. Ayalon and H. Rajendran, “Interplay of asexual and sexual reproduction in bifunctional insects,” Journal of the Royal Society Interface, vol. 22, no. 229. The Royal Society, 2025. ista: Ayalon O, Rajendran H. 2025. Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. 22(229), 20250202. mla: Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” Journal of the Royal Society Interface, vol. 22, no. 229, 20250202, The Royal Society, 2025, doi:10.1098/rsif.2025.0202. short: O. Ayalon, H. Rajendran, Journal of the Royal Society Interface 22 (2025). corr_author: '1' date_created: 2025-08-24T22:01:30Z date_published: 2025-08-13T00:00:00Z date_updated: 2025-09-30T14:24:40Z day: '13' department: - _id: SyCr doi: 10.1098/rsif.2025.0202 external_id: isi: - '001548084900001' pmid: - '40799050' intvolume: ' 22' isi: 1 issue: '229' language: - iso: eng month: '08' oa_version: None pmid: 1 publication: Journal of the Royal Society Interface publication_identifier: eissn: - 1742-5662 issn: - 1742-5689 publication_status: published publisher: The Royal Society quality_controlled: '1' scopus_import: '1' status: public title: Interplay of asexual and sexual reproduction in bifunctional insects type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 22 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '20220' abstract: - lang: eng text: Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress. acknowledged_ssus: - _id: Bio acknowledgement: "We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa (Shimane University, Matsue) for providing the pGWB604 Gateway vector containing bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University) for the critical reading and comments on this manuscript. We further thank J. Mehrmann (Hamburg University) for technical assistance. We thank the ISTA imaging facility for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO (JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant 101034413, and a federal grant from the state of Hamburg (LFF-BiCon)." article_processing_charge: Yes article_type: original author: - first_name: Joke G full_name: De Jaeger-Braet, Joke G id: 26bd38d3-c59a-11ee-a1af-d7a988cafcc5 last_name: De Jaeger-Braet - first_name: Merle full_name: Hartmann, Merle last_name: Hartmann - first_name: Lev full_name: Böttger, Lev last_name: Böttger - first_name: Chao full_name: Yang, Chao id: 082e3e6e-8069-11ed-8390-c8cce7b1aaca last_name: Yang - first_name: Takahiro full_name: Hamada, Takahiro last_name: Hamada - first_name: Stefan full_name: Hoth, Stefan last_name: Hoth - first_name: Xiaoqi full_name: Feng, Xiaoqi id: e0164712-22ee-11ed-b12a-d80fcdf35958 last_name: Feng orcid: 0000-0002-4008-1234 - first_name: Magdalena full_name: Weingartner, Magdalena last_name: Weingartner - first_name: Arp full_name: Schnittger, Arp last_name: Schnittger citation: ama: De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 2025;11(32):eadr5694. doi:10.1126/sciadv.adr5694 apa: De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth, S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adr5694 chicago: De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.adr5694. ieee: J. G. De Jaeger-Braet et al., “The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat,” Science Advances, vol. 11, no. 32. AAAS, p. eadr5694, 2025. ista: De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 11(32), eadr5694. mla: De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” Science Advances, vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:10.1126/sciadv.adr5694. short: J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth, X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694. date_created: 2025-08-24T22:01:30Z date_published: 2025-08-08T00:00:00Z date_updated: 2025-09-30T14:24:10Z day: '08' ddc: - '580' department: - _id: XiFe doi: 10.1126/sciadv.adr5694 ec_funded: 1 external_id: isi: - '001549102600016' file: - access_level: open_access checksum: 0f1ae246acc9b075f01bf4afe382c8ba content_type: application/pdf creator: dernst date_created: 2025-09-02T07:05:37Z date_updated: 2025-09-02T07:05:37Z file_id: '20270' file_name: 2025_ScienceAdvance_DeJaegerBraet.pdf file_size: 10876817 relation: main_file success: 1 file_date_updated: 2025-09-02T07:05:37Z has_accepted_license: '1' intvolume: ' 11' isi: 1 issue: '32' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: eadr5694 project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' scopus_import: '1' status: public title: The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 11 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20221' abstract: - lang: eng text: We describe the design, synthesis, and single-molecule junction conductance of π-electron molecules bearing both radial and linear π-conjugation pathways, whereby cycloparaphenylene (CPP) radial cores are π-extended linearly with aryl alkyne substituents as models for previously reported CPP-arylene ethynylene conjugated polymers. Although radially and linearly conjugated molecules have been studied previously in isolation as junction-bridging molecular electronic units, this is the first study to examine molecules where both topologies are operative. Our results reveal that the presence of radial CPP components within the junction-spanning pathway leads to a reduction in the conductance of the backbone compared to model linear phenyl substituents. Through tight-binding and DFT-based calculations, we attribute this conductance change to intramolecular van der Waals (vdW) interactions between the CPP ring and the junction-spanning arylene-ethynylene molecular backbone. These interactions induce changes in the dihedral angles of the backbone, leading to a reduced overlap of π orbitals within the molecular junction. acknowledgement: We thank Prof. Volker Blum for useful discussions. We thank the Department of Energy Office of Basic Energy Science (DE-SC0019017) and the National Science Foundation (NSF-DMR 2241180) for supporting this research. This work was supported in part by the Institute of Science and Technology Austria. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Wanzhuo full_name: Shi, Wanzhuo id: a3010425-87c8-11f0-8106-bec32bea74da last_name: Shi - first_name: Mengjiao full_name: Wang, Mengjiao last_name: Wang - first_name: Latha full_name: Venkataraman, Latha id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf last_name: Venkataraman orcid: 0000-0002-6957-6089 - first_name: John D. full_name: Tovar, John D. last_name: Tovar citation: ama: Shi W, Wang M, Venkataraman L, Tovar JD. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. 2025;25(31):12101-12106. doi:10.1021/acs.nanolett.5c03693 apa: Shi, W., Wang, M., Venkataraman, L., & Tovar, J. D. (2025). Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. American Chemical Society. https://doi.org/10.1021/acs.nanolett.5c03693 chicago: Shi, Wanzhuo, Mengjiao Wang, Latha Venkataraman, and John D. Tovar. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” Nano Letters. American Chemical Society, 2025. https://doi.org/10.1021/acs.nanolett.5c03693. ieee: W. Shi, M. Wang, L. Venkataraman, and J. D. Tovar, “Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction,” Nano Letters, vol. 25, no. 31. American Chemical Society, pp. 12101–12106, 2025. ista: Shi W, Wang M, Venkataraman L, Tovar JD. 2025. Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction. Nano Letters. 25(31), 12101–12106. mla: Shi, Wanzhuo, et al. “Single-Molecule Conductance through Hybrid Radially and Linearly π-Conjugated Macromolecules Reveals an Unusual Intramolecular π-Interaction.” Nano Letters, vol. 25, no. 31, American Chemical Society, 2025, pp. 12101–06, doi:10.1021/acs.nanolett.5c03693. short: W. Shi, M. Wang, L. Venkataraman, J.D. Tovar, Nano Letters 25 (2025) 12101–12106. corr_author: '1' date_created: 2025-08-24T22:01:30Z date_published: 2025-07-24T00:00:00Z date_updated: 2025-09-30T14:23:39Z day: '24' ddc: - '540' department: - _id: LaVe doi: 10.1021/acs.nanolett.5c03693 external_id: isi: - '001537145800001' pmid: - '40707400' file: - access_level: open_access checksum: bfc167d8904c0c47c3de2a8d0ec699d5 content_type: application/pdf creator: dernst date_created: 2025-09-02T06:50:11Z date_updated: 2025-09-02T06:50:11Z file_id: '20269' file_name: 2025_NanoLetters_Shi.pdf file_size: 3212706 relation: main_file success: 1 file_date_updated: 2025-09-02T06:50:11Z has_accepted_license: '1' intvolume: ' 25' isi: 1 issue: '31' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 12101-12106 pmid: 1 publication: Nano Letters publication_identifier: eissn: - 1530-6992 publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: Single-molecule conductance through hybrid radially and linearly π-conjugated macromolecules reveals an unusual intramolecular π-interaction tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 25 year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20223' abstract: - lang: eng text: The first influential hypothesis for sex chromosome evolution was proposed in 1914 by H. J. Muller, who argued that once recombination was suppressed between the X and Y chromosomes, Y-linked genes become “sheltered” from selection, leading to accumulation of recessive loss-of-function (LOF) mutations and decay of Y-linked genes. The hypothesis fell out of favor in the 1970s because early mathematical models failed to support it and data on the dominance of lethal mutations were viewed as incompatible with the hypothesis. We reevaluate the main arguments against Muller's hypothesis and find that they do not conclusively exclude a role for sheltering in sex chromosome evolution. By relaxing restrictive assumptions of earlier models, we show that sheltering promotes fixation of LOF mutations with sexually dimorphic fitness effects, resulting in decay of X-linked genes that are exclusively expressed by males and Y-linked genes that are primarily, though not necessarily exclusively, expressed by females. We further show that drift and other processes contributing to Y degeneration (i.e. selective interference and regulatory evolution) expand conditions of Y-linked gene loss by sheltering. The actual contribution of sheltering to sex chromosome evolution hinges upon the distribution of dominance and sex-specific fitness effects of LOF mutations, which we discuss. acknowledged_ssus: - _id: ScienComp acknowledgement: We thank Filip Ruzicka, Colin Olito, Akane Uesugi, Melissa Toups, Daniel Jeffries, the Associate Editor, and anonymous reviewers, for comments and suggestions on earlier versions of the paper. We are particularly grateful to Deborah Charlesworth and Brian Charlesworth for extensive comments on two different drafts of the manuscript. We also thank Aneil Agrawal and Thomas Lenormand for email correspondence about the data on dominance and ways to interpret it. Technical support was provided by ISTA Scientific Computing Unit. article_number: msaf177 article_processing_charge: Yes article_type: original author: - first_name: Andrea full_name: Mrnjavac, Andrea id: 353FAC84-AE61-11E9-8BFC-00D3E5697425 last_name: Mrnjavac - first_name: Beatriz full_name: Vicoso, Beatriz id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87 last_name: Vicoso orcid: 0000-0002-4579-8306 - first_name: Tim full_name: Connallon, Tim last_name: Connallon citation: ama: Mrnjavac A, Vicoso B, Connallon T. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. 2025;42(8). doi:10.1093/molbev/msaf177 apa: Mrnjavac, A., Vicoso, B., & Connallon, T. (2025). An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msaf177 chicago: Mrnjavac, Andrea, Beatriz Vicoso, and Tim Connallon. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” Molecular Biology and Evolution. Oxford University Press, 2025. https://doi.org/10.1093/molbev/msaf177. ieee: A. Mrnjavac, B. Vicoso, and T. Connallon, “An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content,” Molecular Biology and Evolution, vol. 42, no. 8. Oxford University Press, 2025. ista: Mrnjavac A, Vicoso B, Connallon T. 2025. An extension of Muller’s sheltering hypothesis for the evolution of sex chromosome gene content. Molecular Biology and Evolution. 42(8), msaf177. mla: Mrnjavac, Andrea, et al. “An Extension of Muller’s Sheltering Hypothesis for the Evolution of Sex Chromosome Gene Content.” Molecular Biology and Evolution, vol. 42, no. 8, msaf177, Oxford University Press, 2025, doi:10.1093/molbev/msaf177. short: A. Mrnjavac, B. Vicoso, T. Connallon, Molecular Biology and Evolution 42 (2025). date_created: 2025-08-24T22:01:31Z date_published: 2025-08-01T00:00:00Z date_updated: 2025-09-30T14:25:57Z day: '01' ddc: - '570' department: - _id: BeVi doi: 10.1093/molbev/msaf177 external_id: isi: - '001547617100001' pmid: - '40713898' file: - access_level: open_access checksum: f40abffa56cb1e9ff65800f2a7d7b39a content_type: application/pdf creator: dernst date_created: 2025-09-02T07:47:32Z date_updated: 2025-09-02T07:47:32Z file_id: '20274' file_name: 2025_MolecularBioEvolution_Mrnjavac.pdf file_size: 1239841 relation: main_file success: 1 file_date_updated: 2025-09-02T07:47:32Z has_accepted_license: '1' intvolume: ' 42' isi: 1 issue: '8' language: - iso: eng month: '08' oa: 1 oa_version: Published Version pmid: 1 publication: Molecular Biology and Evolution publication_identifier: eissn: - 1537-1719 issn: - 0737-4038 publication_status: published publisher: Oxford University Press quality_controlled: '1' related_material: link: - relation: software url: https://git.ista.ac.at/bvicoso/xydegenerate scopus_import: '1' status: public title: An extension of Muller's sheltering hypothesis for the evolution of sex chromosome gene content tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 42 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '20224' abstract: - lang: eng text: "Traffic in datacenters may follow some pattern: some pairs of servers communicate more frequently than others. Demand-oblivious networks may perform poorly for such workloads, and demand-aware networks optimized for traffic should be used instead. Unfortunately, not all shapes of networks are feasible in real hardware. Practical limitations are usually provided in the form of a topology. For example, a network may be required to be a binary tree, a bounded-degree graph or a Fat tree.\r\nIn this work, we consider a topology of a binary tree, one of the most fundamental network topologies. We show that already finding an optimal demand-aware binary tree network is NP-hard. Then, we explore how various optimization techniques, including simple local searches, as well as deterministic mutation and crossover operators, cope with generating efficient tree networks on real-life and synthetic workloads." acknowledgement: Research was supported by the German Research Foundation (DFG), grant 470029389 (FlexNets). article_processing_charge: Yes (in subscription journal) author: - first_name: Pavel full_name: Martynov, Pavel last_name: Martynov - first_name: Maxim full_name: Buzdalov, Maxim last_name: Buzdalov - first_name: Sergei full_name: Pankratov, Sergei id: f773bf05-72ef-11ef-b75a-a383d22f454b last_name: Pankratov - first_name: Vitaliy full_name: Aksenov, Vitaliy last_name: Aksenov - first_name: Stefan full_name: Schmid, Stefan last_name: Schmid citation: ama: 'Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. In the search of optimal tree networks: Hardness and heuristics. In: Proceedings of the 2025 Genetic and Evolutionary Computation Conference. Association for Computing Machinery; 2025:249-257. doi:10.1145/3712256.3726425' apa: 'Martynov, P., Buzdalov, M., Pankratov, S., Aksenov, V., & Schmid, S. (2025). In the search of optimal tree networks: Hardness and heuristics. In Proceedings of the 2025 Genetic and Evolutionary Computation Conference (pp. 249–257). Malaga, Spain: Association for Computing Machinery. https://doi.org/10.1145/3712256.3726425' chicago: 'Martynov, Pavel, Maxim Buzdalov, Sergei Pankratov, Vitaliy Aksenov, and Stefan Schmid. “In the Search of Optimal Tree Networks: Hardness and Heuristics.” In Proceedings of the 2025 Genetic and Evolutionary Computation Conference, 249–57. Association for Computing Machinery, 2025. https://doi.org/10.1145/3712256.3726425.' ieee: 'P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, and S. Schmid, “In the search of optimal tree networks: Hardness and heuristics,” in Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Malaga, Spain, 2025, pp. 249–257.' ista: 'Martynov P, Buzdalov M, Pankratov S, Aksenov V, Schmid S. 2025. In the search of optimal tree networks: Hardness and heuristics. Proceedings of the 2025 Genetic and Evolutionary Computation Conference. GECCO: Genetic and evolutionary computation conference, 249–257.' mla: 'Martynov, Pavel, et al. “In the Search of Optimal Tree Networks: Hardness and Heuristics.” Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Association for Computing Machinery, 2025, pp. 249–57, doi:10.1145/3712256.3726425.' short: P. Martynov, M. Buzdalov, S. Pankratov, V. Aksenov, S. Schmid, in:, Proceedings of the 2025 Genetic and Evolutionary Computation Conference, Association for Computing Machinery, 2025, pp. 249–257. conference: end_date: 2025-07-18 location: Malaga, Spain name: 'GECCO: Genetic and evolutionary computation conference' start_date: 2025-07-14 date_created: 2025-08-24T22:01:31Z date_published: 2025-07-13T00:00:00Z date_updated: 2025-12-01T12:35:24Z day: '13' ddc: - '000' department: - _id: DaAl doi: 10.1145/3712256.3726425 external_id: isi: - '001556459900031' file: - access_level: open_access checksum: 7e513fa508cff7e8a0d33f50b1fe09af content_type: application/pdf creator: dernst date_created: 2025-09-02T07:41:13Z date_updated: 2025-09-02T07:41:13Z file_id: '20273' file_name: 2025_GECCO_Martynov.pdf file_size: 608996 relation: main_file success: 1 file_date_updated: 2025-09-02T07:41:13Z has_accepted_license: '1' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 249-257 publication: Proceedings of the 2025 Genetic and Evolutionary Computation Conference publication_identifier: isbn: - '9798400714658' publication_status: published publisher: Association for Computing Machinery quality_controlled: '1' scopus_import: '1' status: public title: 'In the search of optimal tree networks: Hardness and heuristics' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '20225' abstract: - lang: eng text: "We present the first supermartingale certificate for quantitative \r\n-regular properties of discrete-time infinite-state stochastic systems. Our certificate is defined on the product of the stochastic system and a limit-deterministic Büchi automaton that specifies the property of interest; hence we call it a limit-deterministic Büchi supermartingale (LDBSM). Previously known supermartingale certificates applied only to quantitative reachability, safety, or reach-avoid properties, and to qualitative (i.e., probability 1) \r\n-regular properties.We also present fully automated algorithms for the template-based synthesis of LDBSMs, for the case when the stochastic system dynamics and the controller can be represented in terms of polynomial inequalities. Our experiments demonstrate the ability of our method to solve verification and control tasks for stochastic systems that were beyond the reach of previous supermartingale-based approaches." acknowledgement: This work was supported in part by the Singapore Ministry of Education (MOE) Academic Research Fund (AcRF) Tier 1 grant (Project ID:22-SIS-SMU-100) and the ERC project ERC-2020-AdG 101020093. alternative_title: - LNCS article_processing_charge: Yes (in subscription journal) arxiv: 1 author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 - first_name: Kaushik full_name: Mallik, Kaushik id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598 last_name: Mallik orcid: 0000-0001-9864-7475 - first_name: Pouya full_name: Sadeghi, Pouya last_name: Sadeghi - first_name: Dorde full_name: Zikelic, Dorde id: 294AA7A6-F248-11E8-B48F-1D18A9856A87 last_name: Zikelic orcid: 0000-0002-4681-1699 citation: ama: 'Henzinger TA, Mallik K, Sadeghi P, Zikelic D. Supermartingale certificates for quantitative omega-regular verification and control. In: 37th International Conference on Computer Aided Verification. Vol 15932. Springer Nature; 2025:29-55. doi:10.1007/978-3-031-98679-6_2' apa: 'Henzinger, T. A., Mallik, K., Sadeghi, P., & Zikelic, D. (2025). Supermartingale certificates for quantitative omega-regular verification and control. In 37th International Conference on Computer Aided Verification (Vol. 15932, pp. 29–55). Zagreb, Croatia: Springer Nature. https://doi.org/10.1007/978-3-031-98679-6_2' chicago: Henzinger, Thomas A, Kaushik Mallik, Pouya Sadeghi, and Dorde Zikelic. “Supermartingale Certificates for Quantitative Omega-Regular Verification and Control.” In 37th International Conference on Computer Aided Verification, 15932:29–55. Springer Nature, 2025. https://doi.org/10.1007/978-3-031-98679-6_2. ieee: T. A. Henzinger, K. Mallik, P. Sadeghi, and D. Zikelic, “Supermartingale certificates for quantitative omega-regular verification and control,” in 37th International Conference on Computer Aided Verification, Zagreb, Croatia, 2025, vol. 15932, pp. 29–55. ista: 'Henzinger TA, Mallik K, Sadeghi P, Zikelic D. 2025. Supermartingale certificates for quantitative omega-regular verification and control. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15932, 29–55.' mla: Henzinger, Thomas A., et al. “Supermartingale Certificates for Quantitative Omega-Regular Verification and Control.” 37th International Conference on Computer Aided Verification, vol. 15932, Springer Nature, 2025, pp. 29–55, doi:10.1007/978-3-031-98679-6_2. short: T.A. Henzinger, K. Mallik, P. Sadeghi, D. Zikelic, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 29–55. conference: end_date: 2025-07-25 location: Zagreb, Croatia name: 'CAV: Computer Aided Verification' start_date: 2025-07-23 date_created: 2025-08-24T22:01:31Z date_published: 2025-07-22T00:00:00Z date_updated: 2025-12-01T12:34:41Z day: '22' ddc: - '000' department: - _id: ToHe doi: 10.1007/978-3-031-98679-6_2 ec_funded: 1 external_id: arxiv: - '2505.18833' isi: - '001562506600002' file: - access_level: open_access checksum: beb1e2637de5b2268cc2262119439113 content_type: application/pdf creator: dernst date_created: 2025-09-02T07:34:33Z date_updated: 2025-09-02T07:34:33Z file_id: '20272' file_name: 2025_CAV_HenzingerT.pdf file_size: 884831 relation: main_file success: 1 file_date_updated: 2025-09-02T07:34:33Z has_accepted_license: '1' intvolume: ' 15932' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 29-55 project: - _id: 62781420-2b32-11ec-9570-8d9b63373d4d call_identifier: H2020 grant_number: '101020093' name: Vigilant Algorithmic Monitoring of Software publication: 37th International Conference on Computer Aided Verification publication_identifier: eissn: - 1611-3349 isbn: - '9783031986789' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Supermartingale certificates for quantitative omega-regular verification and control tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 15932 year: '2025' ... --- _id: '20242' abstract: - lang: eng text: "This repository contains calculations of carbon footprints of NMR conferences, as described in the article by \r\nLucky N. Kapoor, Natalia Ruzickova, Predrag Živadinović, Valentin Leitner, Maria Anna Sisak, Cecelia Mweka, Jeroen Dobbelaere, Georgios Katsaros, and Paul Schanda\r\nPublished in Magnetic Resonance, 2025." article_processing_charge: No author: - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 citation: ama: 'Schanda P. Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” 2025. doi:10.15479/AT-ISTA-20242' apa: 'Schanda, P. (2025). Data of: “Quantifying the carbon footprint of conference travel: the case of NMR meetings.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20242' chicago: 'Schanda, Paul. “Data of: ‘Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20242.' ieee: 'P. Schanda, “Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings.’” Institute of Science and Technology Austria, 2025.' ista: 'Schanda P. 2025. Data of: ‘Quantifying the carbon footprint of conference travel: the case of NMR meetings’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-20242.' mla: 'Schanda, Paul. Data of: “Quantifying the Carbon Footprint of Conference Travel: The Case of NMR Meetings.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20242.' short: P. Schanda, (2025). contributor: - contributor_type: researcher first_name: Natalia id: D2761128-D73D-11E9-A1BF-BA0DE6697425 last_name: Ruzickova - contributor_type: researcher first_name: Lucky id: 84b9700b-15b2-11ec-abd3-831089e67615 last_name: Kapoor - contributor_type: researcher first_name: Valentin id: 4c665ce3-0016-11ec-bea0-e44de7a4fa3d last_name: Leitner - contributor_type: researcher first_name: Predrag id: 68AA0E5A-AFDA-11E9-9994-141DE6697425 last_name: Zivadinovic - contributor_type: researcher first_name: Maria A id: 44A03D04-AEA4-11E9-B225-EA2DE6697425 last_name: Sisak - contributor_type: researcher first_name: Cecelia N id: 2a69ab4b-896a-11ed-bdf8-cb8641cf2b21 last_name: Mweka - contributor_type: supervisor first_name: Jeroen A id: c15a5412-de82-11ed-b809-8dc1aa996e40 last_name: Dobbelaere - contributor_type: supervisor first_name: Georgios id: 38DB5788-F248-11E8-B48F-1D18A9856A87 last_name: Katsaros orcid: 0000-0001-8342-202X corr_author: '1' date_created: 2025-08-31T15:14:18Z date_published: 2025-09-01T00:00:00Z date_updated: 2026-06-10T08:45:12Z department: - _id: PaSc doi: 10.15479/AT-ISTA-20242 file: - access_level: open_access checksum: 055044b03f835cb98c45d0504f1db96e content_type: application/zip creator: pschanda date_created: 2025-08-31T15:09:44Z date_updated: 2025-08-31T15:09:44Z file_id: '20244' file_name: Abstracts.zip file_size: 42368943 relation: main_file success: 1 - access_level: open_access checksum: 1492683af736ac65088b77e12b52c3b0 content_type: application/zip creator: pschanda date_created: 2025-08-31T15:11:58Z date_updated: 2025-08-31T15:11:58Z file_id: '20245' file_name: data_CO2_conferences.zip file_size: 470659 relation: main_file success: 1 - access_level: open_access checksum: 8ac69071f7508e77b5ca91fa5018339a content_type: application/zip creator: pschanda date_created: 2025-08-31T15:12:03Z date_updated: 2025-08-31T15:12:03Z file_id: '20246' file_name: Figure6_predictions.zip file_size: 1138772 relation: main_file success: 1 - access_level: open_access checksum: 19b77db247feecdc36fbe6f68d94a76d content_type: text/x-python-script creator: pschanda date_created: 2025-08-31T15:12:07Z date_updated: 2025-08-31T15:12:07Z file_id: '20247' file_name: ExcelFileAnalysisCode.py file_size: 6558 relation: main_file success: 1 - access_level: open_access checksum: 39655e28c6df523f4f9662dc58c94623 content_type: application/pdf creator: pschanda date_created: 2025-08-31T15:12:11Z date_updated: 2025-08-31T15:12:11Z file_id: '20248' file_name: emissions_spectrometers_and_Parisgoal.pdf file_size: 1107467 relation: main_file success: 1 - access_level: open_access checksum: 2e9a9460b3f2abe7e46179561a63492b content_type: application/octet-stream creator: pschanda date_created: 2025-09-01T11:05:27Z date_updated: 2025-09-01T11:05:27Z file_id: '20263' file_name: README file_size: 3994 relation: main_file success: 1 file_date_updated: 2025-09-01T11:05:27Z has_accepted_license: '1' keyword: - sustainability - conference travel month: '09' oa: 1 oa_version: Published Version publisher: Institute of Science and Technology Austria related_material: record: - id: '20664' relation: used_in_publication status: public status: public title: 'Data of: "Quantifying the carbon footprint of conference travel: the case of NMR meetings"' tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: research_data user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d year: '2025' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20250' abstract: - lang: eng text: "Population III stars are possible precursors to early supermassive black holes (BHs). The presence of soft UV Lyman–Werner (LW) background radiation can suppress Population III star formation in minihaloes and allow them to form in pristine atomic-cooling haloes. In the absence of molecular hydrogen (⁠H2⁠) cooling, atomic-cooling haloes enable rapid collapse with suppressed fragmentation. High background LW fluxes from preceding star-formation have been proposed to dissociate H2⁠. This flux can be supplemented by LW radiation from one or more Population III star(s) in the same halo, reducing the necessary background level. Here, we consider atomic-cooling haloes in which multiple protostellar cores form close to one another nearly simultaneously. We assess whether the first star’s LW radiation can dissociate nearby \r\n⁠, enabling rapid accretion on to a nearby protostellar core, and the prompt formation of a second, supermassive star (SMS) from warm, atomically-cooled gas. We use a set of hydrodynamical simulations with the code enzo, with identical LW backgrounds centred on a halo with two adjacent collapsing gas clumps. When an additional large local LW flux is introduced, we observe immediate reductions in both the accretion rates and the stellar masses that form within these clumps. While the LW flux reduces the H2 fraction and increases the gas temperature, the halo core’s potential well is too shallow to promptly heat the gas to >1000 K and increase the second protostar’s accretion rate. We conclude that this internal LW feedback scenario is unlikely to facilitate SMS or massive BH seed formation." acknowledgement: We thank the anonymous referee for comments that helped us improve the clarity of this manuscript. We acknowledge support from the United States National Science Foundation (NSF) grant AST-2006176 and the National Aeronautics and Space Administration (NASA) grants 80NSSC24K0440 and 80NSSC22K0822 (ZH). We also acknowledge support from NSF grant AST-2009309, NASA Astrophysics Theory Program grant 80NSSC22K0629, and Space Telescope Science Institute grant JWST-AR-05238 (EV). The simulations in this work were run on Texas Advanced Computing Center’s Stampede2 and Stampede3 systems. We used Stampede2 and Purdue University’s computing system Anvil for data analysis. article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: James full_name: Sullivan, James last_name: Sullivan - first_name: Zoltán full_name: Haiman, Zoltán id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36 last_name: Haiman orcid: 0000-0003-3633-5403 - first_name: Mihir full_name: Kulkarni, Mihir last_name: Kulkarni - first_name: Eli full_name: Visbal, Eli last_name: Visbal citation: ama: Sullivan J, Haiman Z, Kulkarni M, Visbal E. Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback? Monthly Notices of the Royal Astronomical Society. 2025;542(2):822-838. doi:10.1093/mnras/staf1269 apa: Sullivan, J., Haiman, Z., Kulkarni, M., & Visbal, E. (2025). Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback? Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/staf1269 chicago: Sullivan, James, Zoltán Haiman, Mihir Kulkarni, and Eli Visbal. “Can Supermassive Stars Form in Protogalaxies Due to Internal Lyman-Werner Feedback?” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2025. https://doi.org/10.1093/mnras/staf1269. ieee: J. Sullivan, Z. Haiman, M. Kulkarni, and E. Visbal, “Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback?,” Monthly Notices of the Royal Astronomical Society, vol. 542, no. 2. Oxford University Press, pp. 822–838, 2025. ista: Sullivan J, Haiman Z, Kulkarni M, Visbal E. 2025. Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback? Monthly Notices of the Royal Astronomical Society. 542(2), 822–838. mla: Sullivan, James, et al. “Can Supermassive Stars Form in Protogalaxies Due to Internal Lyman-Werner Feedback?” Monthly Notices of the Royal Astronomical Society, vol. 542, no. 2, Oxford University Press, 2025, pp. 822–38, doi:10.1093/mnras/staf1269. short: J. Sullivan, Z. Haiman, M. Kulkarni, E. Visbal, Monthly Notices of the Royal Astronomical Society 542 (2025) 822–838. date_created: 2025-08-31T22:01:31Z date_published: 2025-09-01T00:00:00Z date_updated: 2025-09-30T14:28:05Z day: '01' ddc: - '520' department: - _id: ZoHa doi: 10.1093/mnras/staf1269 external_id: arxiv: - '2501.12986' isi: - '001553472000001' file: - access_level: open_access checksum: 2a06796b27da0b33d479dba170ba4b3f content_type: application/pdf creator: dernst date_created: 2025-09-03T05:44:47Z date_updated: 2025-09-03T05:44:47Z file_id: '20279' file_name: 2025_MonthlyNoticesRAS_Sullivan.pdf file_size: 2780496 relation: main_file success: 1 file_date_updated: 2025-09-03T05:44:47Z has_accepted_license: '1' intvolume: ' 542' isi: 1 issue: '2' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: 822-838 publication: Monthly Notices of the Royal Astronomical Society publication_identifier: eissn: - 1365-2966 issn: - 0035-8711 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: Can supermassive stars form in protogalaxies due to internal Lyman-Werner feedback? tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 542 year: '2025' ... --- OA_place: repository OA_type: green _id: '20251' abstract: - lang: eng text: The Lane–Emden inequality controls (math. formular) in terms of the L^1 and L^p norms of p. We provide a remainder estimate for this inequality in terms of a suitable distance of p to the manifold of optimizers. acknowledgement: We are grateful to Rupert Frank and Enno Lenzmann for helpful discussions. article_number: '226' article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Eric full_name: Carlen, Eric last_name: Carlen - first_name: Mathieu full_name: Lewin, Mathieu last_name: Lewin - first_name: Elliott H. full_name: Lieb, Elliott H. last_name: Lieb - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Carlen E, Lewin M, Lieb EH, Seiringer R. Stability estimate for the Lane–Emden inequality. Calculus of Variations and Partial Differential Equations. 2025;64(7). doi:10.1007/s00526-025-03062-x apa: Carlen, E., Lewin, M., Lieb, E. H., & Seiringer, R. (2025). Stability estimate for the Lane–Emden inequality. Calculus of Variations and Partial Differential Equations. Springer Nature. https://doi.org/10.1007/s00526-025-03062-x chicago: Carlen, Eric, Mathieu Lewin, Elliott H. Lieb, and Robert Seiringer. “Stability Estimate for the Lane–Emden Inequality.” Calculus of Variations and Partial Differential Equations. Springer Nature, 2025. https://doi.org/10.1007/s00526-025-03062-x. ieee: E. Carlen, M. Lewin, E. H. Lieb, and R. Seiringer, “Stability estimate for the Lane–Emden inequality,” Calculus of Variations and Partial Differential Equations, vol. 64, no. 7. Springer Nature, 2025. ista: Carlen E, Lewin M, Lieb EH, Seiringer R. 2025. Stability estimate for the Lane–Emden inequality. Calculus of Variations and Partial Differential Equations. 64(7), 226. mla: Carlen, Eric, et al. “Stability Estimate for the Lane–Emden Inequality.” Calculus of Variations and Partial Differential Equations, vol. 64, no. 7, 226, Springer Nature, 2025, doi:10.1007/s00526-025-03062-x. short: E. Carlen, M. Lewin, E.H. Lieb, R. Seiringer, Calculus of Variations and Partial Differential Equations 64 (2025). date_created: 2025-08-31T22:01:31Z date_published: 2025-09-01T00:00:00Z date_updated: 2025-09-30T14:27:35Z day: '01' department: - _id: RoSe doi: 10.1007/s00526-025-03062-x external_id: arxiv: - '2410.20113' isi: - '001558641300006' intvolume: ' 64' isi: 1 issue: '7' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2410.20113 month: '09' oa: 1 oa_version: Preprint publication: Calculus of Variations and Partial Differential Equations publication_identifier: eissn: - 1432-0835 issn: - 0944-2669 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: Stability estimate for the Lane–Emden inequality type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 64 year: '2025' ... --- OA_place: repository OA_type: green _id: '20252' abstract: - lang: eng text: Zirconia nanocrystals (ZrO2 NCs) are a stable host material for lanthanides, but their performance lags behind that of the leading NaYF4 nanomaterials. Here, we leverage surface chemistry and core/shell architectures to uncover the contribution of dopants at the nanocrystal surface and of dopants in the nanocrystal bulk. We first assess the doping efficiency by ICP and find that, while Eu is almost quantitatively incorporated, the other lanthanides (La, Ce, Tb, Tm, Er, Yb) have about 50% incorporation efficiency over the studied doping range of 1–10%. We then determine the nanocrystal surface chemistry using NMR spectroscopy, despite the additional spectral line broadening caused by the paramagnetic lanthanide dopants. By varying the surface ligands and measuring the photoluminescence, we resolve the spectroscopic signals that are sensitive to a change in surface chemistry. Time-resolved emission spectra further reinforce the notion of a bulk component with a long luminescent lifetime and a surface component with a fast lifetime. Upon shelling Eu- or Tb-doped zirconia NCs with pure zirconia, the surface component disappears, and the photoluminescence quantum yield increases. We further functionalized the surface of the core/shell particles with oleylphosphonic acid ligands to obtain excellent dispersibility. These results show that lanthanide-doped zirconia NCs can be engineered to eliminate deactivation pathways. acknowledged_ssus: - _id: EM-Fac acknowledgement: N.R. and C.S. thank the SNSF Eccellenza funding scheme (Project 194172) for funding. D.V.d.H. is supported by the Research Foundation Flanders (FWO) through a Senior Postdoctoral Research Fellowship (N° 1237825N). P.F.S. acknowledges the Special Research Fund at UGent (bof/baf/4y/2024/01/037). M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation. This research was supported by the Scientific Service Units (SSU) of ISTA Austria through resources provided by the electron microscopy facility (EMF). We thank Tommaso Costanzo for providing assistance during STEM measurements. We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz Association HGF, for the provision of experimental facilities. Parts of this research were carried out using beamline P21.1 at PETRA III, and the authors thank Ann-Christin Dippel, Jiatu Liu, and Fernando Igoa for assistance in using the beamline for PDF acquisition (Proposal I-20231114 EC). The authors thank Daniel Häussinger for help with the analysis of NMR spectra. article_processing_charge: No article_type: original author: - first_name: Nico full_name: Reichholf, Nico last_name: Reichholf - first_name: Sharona full_name: Horta, Sharona id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc last_name: Horta - first_name: David full_name: Van Der Heggen, David last_name: Van Der Heggen - first_name: Carlotta full_name: Seno, Carlotta last_name: Seno - first_name: Jikson full_name: Pulparayil Mathew, Jikson last_name: Pulparayil Mathew - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 - first_name: Philippe F. full_name: Smet, Philippe F. last_name: Smet - first_name: Jonathan full_name: De Roo, Jonathan last_name: De Roo citation: ama: Reichholf N, Horta S, Van Der Heggen D, et al. Identification and elimination of surface emission in lanthanide (Co)doped zirconia nanocrystals. ACS Nano. 2025;19(33):30371-30382. doi:10.1021/acsnano.5c09137 apa: Reichholf, N., Horta, S., Van Der Heggen, D., Seno, C., Pulparayil Mathew, J., Ibáñez, M., … De Roo, J. (2025). Identification and elimination of surface emission in lanthanide (Co)doped zirconia nanocrystals. ACS Nano. American Chemical Society. https://doi.org/10.1021/acsnano.5c09137 chicago: Reichholf, Nico, Sharona Horta, David Van Der Heggen, Carlotta Seno, Jikson Pulparayil Mathew, Maria Ibáñez, Philippe F. Smet, and Jonathan De Roo. “Identification and Elimination of Surface Emission in Lanthanide (Co)Doped Zirconia Nanocrystals.” ACS Nano. American Chemical Society, 2025. https://doi.org/10.1021/acsnano.5c09137. ieee: N. Reichholf et al., “Identification and elimination of surface emission in lanthanide (Co)doped zirconia nanocrystals,” ACS Nano, vol. 19, no. 33. American Chemical Society, pp. 30371–30382, 2025. ista: Reichholf N, Horta S, Van Der Heggen D, Seno C, Pulparayil Mathew J, Ibáñez M, Smet PF, De Roo J. 2025. Identification and elimination of surface emission in lanthanide (Co)doped zirconia nanocrystals. ACS Nano. 19(33), 30371–30382. mla: Reichholf, Nico, et al. “Identification and Elimination of Surface Emission in Lanthanide (Co)Doped Zirconia Nanocrystals.” ACS Nano, vol. 19, no. 33, American Chemical Society, 2025, pp. 30371–82, doi:10.1021/acsnano.5c09137. short: N. Reichholf, S. Horta, D. Van Der Heggen, C. Seno, J. Pulparayil Mathew, M. Ibáñez, P.F. Smet, J. De Roo, ACS Nano 19 (2025) 30371–30382. date_created: 2025-08-31T22:01:31Z date_published: 2025-08-26T00:00:00Z date_updated: 2025-09-30T14:27:03Z day: '26' department: - _id: MaIb doi: 10.1021/acsnano.5c09137 external_id: isi: - '001550173000001' intvolume: ' 19' isi: 1 issue: '33' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.26434/chemrxiv-2025-r1gw4 month: '08' oa: 1 oa_version: Preprint page: 30371-30382 project: - _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery' publication: ACS Nano publication_identifier: eissn: - 1936-086X publication_status: published publisher: American Chemical Society quality_controlled: '1' scopus_import: '1' status: public title: Identification and elimination of surface emission in lanthanide (Co)doped zirconia nanocrystals type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 19 year: '2025' ... --- OA_place: publisher OA_type: gold _id: '20253' abstract: - lang: eng text: "A quantitative word automaton (QWA) defines a function from infinite words to values. For example, every infinite run of a limit-average QWA \U0001D49C obtains a mean payoff, and every word w ∈ Σ^ω is assigned the maximal mean payoff obtained by nondeterministic runs of \U0001D49C over w. We introduce quantitative language automata (QLAs) that define functions from language generators (i.e., implementations) to values, where a language generator can be nonprobabilistic, defining a set of infinite words, or probabilistic, defining a probability measure over infinite words. A QLA consists of a QWA and an aggregator function. For example, given a QWA \U0001D49C, the infimum aggregator maps each language L ⊆ Σ^ω to the greatest lower bound assigned by \U0001D49C to any word in L. For boolean value sets, QWAs define boolean properties of traces, and QLAs define boolean properties of sets of traces, i.e., hyperproperties. For more general value sets, QLAs serve as a specification language for a generalization of hyperproperties, called quantitative hyperproperties. A nonprobabilistic (resp. probabilistic) quantitative hyperproperty assigns a value to each set (resp. distribution) G of traces, e.g., the minimal (resp. expected) average response time exhibited by the traces in G. We give several examples of quantitative hyperproperties and investigate three paradigmatic problems for QLAs: evaluation, nonemptiness, and universality. In the evaluation problem, given a QLA \U0001D538 and an implementation G, we ask for the value that \U0001D538 assigns to G. In the nonemptiness (resp. universality) problem, given a QLA \U0001D538 and a value k, we ask whether \U0001D538 assigns at least k to some (resp. every) language. We provide a comprehensive picture of decidability for these problems for QLAs with common aggregators as well as their restrictions to ω-regular languages and trace distributions generated by finite-state Markov chains." acknowledgement: This work was supported in part by the ERC-2020-AdG 101020093. alternative_title: - LIPIcs article_number: '21' article_processing_charge: No arxiv: 1 author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 - first_name: Pavol full_name: Kebis, Pavol id: 2e0132b3-4e98-11ef-b275-cf7281c2802a last_name: Kebis - first_name: Nicolas Adrien full_name: Mazzocchi, Nicolas Adrien id: b26baa86-3308-11ec-87b0-8990f34baa85 last_name: Mazzocchi - first_name: Naci E full_name: Sarac, Naci E id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425 last_name: Sarac citation: ama: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. Quantitative language automata. In: 36th International Conference on Concurrency Theory. Vol 348. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2025. doi:10.4230/LIPIcs.CONCUR.2025.21' apa: 'Henzinger, T. A., Kebis, P., Mazzocchi, N. A., & Sarac, N. E. (2025). Quantitative language automata. In 36th International Conference on Concurrency Theory (Vol. 348). Aarhus, Denmark: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2025.21' chicago: Henzinger, Thomas A, Pavol Kebis, Nicolas Adrien Mazzocchi, and Naci E Sarac. “Quantitative Language Automata.” In 36th International Conference on Concurrency Theory, Vol. 348. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025. https://doi.org/10.4230/LIPIcs.CONCUR.2025.21. ieee: T. A. Henzinger, P. Kebis, N. A. Mazzocchi, and N. E. Sarac, “Quantitative language automata,” in 36th International Conference on Concurrency Theory, Aarhus, Denmark, 2025, vol. 348. ista: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. 2025. Quantitative language automata. 36th International Conference on Concurrency Theory. CONCUR: Conference on Concurrency Theory, LIPIcs, vol. 348, 21.' mla: Henzinger, Thomas A., et al. “Quantitative Language Automata.” 36th International Conference on Concurrency Theory, vol. 348, 21, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025, doi:10.4230/LIPIcs.CONCUR.2025.21. short: T.A. Henzinger, P. Kebis, N.A. Mazzocchi, N.E. Sarac, in:, 36th International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025. conference: end_date: 2025-08-29 location: Aarhus, Denmark name: 'CONCUR: Conference on Concurrency Theory' start_date: 2025-08-26 corr_author: '1' date_created: 2025-08-31T22:01:32Z date_published: 2025-08-18T00:00:00Z date_updated: 2025-12-01T12:36:52Z day: '18' ddc: - '000' department: - _id: ToHe doi: 10.4230/LIPIcs.CONCUR.2025.21 ec_funded: 1 external_id: arxiv: - '2506.0515' isi: - '001570540800021' file: - access_level: open_access checksum: 9d4054058757a73477e6015b10ed6996 content_type: application/pdf creator: dernst date_created: 2025-09-03T10:01:53Z date_updated: 2025-09-03T10:01:53Z file_id: '20282' file_name: 2025_CONCUR_HenzingerT.pdf file_size: 1257397 relation: main_file success: 1 file_date_updated: 2025-09-03T10:01:53Z has_accepted_license: '1' intvolume: ' 348' isi: 1 language: - iso: eng month: '08' oa: 1 oa_version: Published Version project: - _id: 62781420-2b32-11ec-9570-8d9b63373d4d call_identifier: H2020 grant_number: '101020093' name: Vigilant Algorithmic Monitoring of Software publication: 36th International Conference on Concurrency Theory publication_identifier: isbn: - '9783959773898' issn: - 1868-8969 publication_status: published publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik quality_controlled: '1' scopus_import: '1' status: public title: Quantitative language automata tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 348 year: '2025' ... --- APC_amount: 4493,27 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20254' abstract: - lang: eng text: 'We examine population structures for their ability to maintain diversity in neutral evolution. We use the general framework of evolutionary graph theory and consider birth–death (bd) and death–birth (db) updating. The population is of size N. Initially all individuals represent different types. The basic question is: what is the time TN until one type takes over the population? This time is known as consensus time in computer science and as total coalescent time in evolutionary biology. For the complete graph, it is known that TN is quadratic in N for db and bd. For the cycle, we prove that TN is cubic in N for db and bd. For the star, we prove that TN is cubic for bd and quasilinear (N log N) for db. For the double star, we show that TN is quartic for bd. We derive upper and lower bounds for all undirected graphs for bd and db. We also show the Pareto front of graphs (of size N = 8) that maintain diversity the longest for bd and db. Further, we show that some graphs that quickly homogenize can maintain high levels of diversity longer than graphs that slowly homogenize. For directed graphs, we give simple contracting star-like structures that have superexponential time scales for maintaining diversity.' acknowledgement: J.S. and K.C. were supported by the European Research Council CoG 863818 (ForM-SMArt) and Austrian Science Fund 10.55776/COE12. J.T. was supported by GAČR grant 25-17377S and by Charles Univ. projects UNCE 24/SCI/008 and PRIMUS 24/SCI/012. article_number: pgaf252 article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: David A. full_name: Brewster, David A. last_name: Brewster - first_name: Jakub full_name: Svoboda, Jakub id: 130759D2-D7DD-11E9-87D2-DE0DE6697425 last_name: Svoboda orcid: 0000-0002-1419-3267 - first_name: Dylan full_name: Roscow, Dylan last_name: Roscow - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Josef full_name: Tkadlec, Josef id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87 last_name: Tkadlec orcid: 0000-0002-1097-9684 - first_name: Martin A. full_name: Nowak, Martin A. last_name: Nowak citation: ama: Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. Maintaining diversity in structured populations. PNAS Nexus. 2025;4(8). doi:10.1093/pnasnexus/pgaf252 apa: Brewster, D. A., Svoboda, J., Roscow, D., Chatterjee, K., Tkadlec, J., & Nowak, M. A. (2025). Maintaining diversity in structured populations. PNAS Nexus. Oxford University Press. https://doi.org/10.1093/pnasnexus/pgaf252 chicago: Brewster, David A., Jakub Svoboda, Dylan Roscow, Krishnendu Chatterjee, Josef Tkadlec, and Martin A. Nowak. “Maintaining Diversity in Structured Populations.” PNAS Nexus. Oxford University Press, 2025. https://doi.org/10.1093/pnasnexus/pgaf252. ieee: D. A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, and M. A. Nowak, “Maintaining diversity in structured populations,” PNAS Nexus, vol. 4, no. 8. Oxford University Press, 2025. ista: Brewster DA, Svoboda J, Roscow D, Chatterjee K, Tkadlec J, Nowak MA. 2025. Maintaining diversity in structured populations. PNAS Nexus. 4(8), pgaf252. mla: Brewster, David A., et al. “Maintaining Diversity in Structured Populations.” PNAS Nexus, vol. 4, no. 8, pgaf252, Oxford University Press, 2025, doi:10.1093/pnasnexus/pgaf252. short: D.A. Brewster, J. Svoboda, D. Roscow, K. Chatterjee, J. Tkadlec, M.A. Nowak, PNAS Nexus 4 (2025). date_created: 2025-08-31T22:01:32Z date_published: 2025-08-01T00:00:00Z date_updated: 2026-06-11T09:11:17Z day: '01' ddc: - '000' department: - _id: KrCh doi: 10.1093/pnasnexus/pgaf252 ec_funded: 1 external_id: arxiv: - '2503.09841' file: - access_level: open_access checksum: 8a5e82c6f842e3220ec96028c9374b69 content_type: application/pdf creator: dernst date_created: 2025-09-03T06:20:08Z date_updated: 2025-09-03T06:20:08Z file_id: '20280' file_name: 2025_PNASNexus_Brewster.pdf file_size: 1086419 relation: main_file success: 1 file_date_updated: 2025-09-03T06:20:08Z has_accepted_license: '1' intvolume: ' 4' issue: '8' language: - iso: eng month: '08' oa: 1 oa_version: Published Version project: - _id: 0599E47C-7A3F-11EA-A408-12923DDC885E call_identifier: H2020 grant_number: '863818' name: 'Formal Methods for Stochastic Models: Algorithms and Applications' publication: PNAS Nexus publication_identifier: eissn: - 2752-6542 publication_status: published publisher: Oxford University Press quality_controlled: '1' scopus_import: '1' status: public title: Maintaining diversity in structured populations tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 4 year: '2025' ... --- OA_place: repository OA_type: green _id: '20255' abstract: - lang: eng text: With stunning clarity, the JWST has revealed the Universe’s first billion years. The scientific community is analysing a wealth of JWST imaging and spectroscopic data from that era, and is in the process of rewriting the astronomy textbooks. Here, as a result of the 2024 ISSI Breakthrough Workshop, we provide a snapshot of the great progress made towards understanding the initial chapters of our cosmic history 1.5 years into the JWST science mission. We present the current census of early galaxies, their luminosities, appearance, chemical composition, masses and formation histories as revealed by JWST. We relate the discovery of massive black holes in early galaxies and discuss their demographics and implications for their formations and growth. We conclude by describing the potential sources of reionization and our current understanding of how the Universe became fully ionized. Throughout the Perspective, we highlight discoveries and breakthroughs, topics and issues that are not yet understood, and questions that will be addressed in the coming years, as JWST continues its revolutionary observations of the early Universe. acknowledgement: While this Perspective is written by a small number of authors, invited to ISSI Bern in March 2024 as part of the 2024 ISSI Breakthrough Workshop, we acknowledge the work of a large community that is advancing our collective understanding of the evolution of the early Universe. We thank ISSI for sponsoring the 2024 Breakthrough Workshop, and the ISSI staff for their wonderful welcome and support. We are grateful to the author collaborators, who made this paper possible. Collectively, we are grateful to the large group of committed scientists and engineers, worldwide, who designed, built and commissioned the JWST and made a decades-long astronomer dream a reality. R.P.N. is a NASA Hubble Fellow. We are grateful to M. Dickinson for a careful read of the final paper and to F. Crameri (ISSI) for his expert help designing the very best figures. We dedicate this paper to the 20,000 people who spent decades to make JWST an incredible discovery machine. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Angela full_name: Adamo, Angela last_name: Adamo - first_name: Hakim full_name: Atek, Hakim last_name: Atek - first_name: Micaela B. full_name: Bagley, Micaela B. last_name: Bagley - first_name: Eduardo full_name: Bañados, Eduardo last_name: Bañados - first_name: Kirk S.S. full_name: Barrow, Kirk S.S. last_name: Barrow - first_name: Danielle A. full_name: Berg, Danielle A. last_name: Berg - first_name: Rachel full_name: Bezanson, Rachel last_name: Bezanson - first_name: Maruša full_name: Bradač, Maruša last_name: Bradač - first_name: Gabriel full_name: Brammer, Gabriel last_name: Brammer - first_name: Adam C. full_name: Carnall, Adam C. last_name: Carnall - first_name: John full_name: Chisholm, John last_name: Chisholm - first_name: Dan full_name: Coe, Dan last_name: Coe - first_name: Pratika full_name: Dayal, Pratika last_name: Dayal - first_name: Daniel J. full_name: Eisenstein, Daniel J. last_name: Eisenstein - first_name: Jan J. full_name: Eldridge, Jan J. last_name: Eldridge - first_name: Andrea full_name: Ferrara, Andrea last_name: Ferrara - first_name: Seiji full_name: Fujimoto, Seiji last_name: Fujimoto - first_name: Anna De full_name: Graaff, Anna De last_name: Graaff - first_name: Melanie full_name: Habouzit, Melanie last_name: Habouzit - first_name: Taylor A. full_name: Hutchison, Taylor A. last_name: Hutchison - first_name: Jeyhan S. full_name: Kartaltepe, Jeyhan S. last_name: Kartaltepe - first_name: Susan A. full_name: Kassin, Susan A. last_name: Kassin - first_name: Mariska full_name: Kriek, Mariska last_name: Kriek - first_name: Ivo full_name: Labbé, Ivo last_name: Labbé - first_name: Roberto full_name: Maiolino, Roberto last_name: Maiolino - first_name: Rui full_name: Marques-Chaves, Rui last_name: Marques-Chaves - first_name: Michael V. full_name: Maseda, Michael V. last_name: Maseda - first_name: Charlotte full_name: Mason, Charlotte last_name: Mason - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Kristen B.W. full_name: Mcquinn, Kristen B.W. last_name: Mcquinn - first_name: Georges full_name: Meynet, Georges last_name: Meynet - first_name: Rohan P. full_name: Naidu, Rohan P. last_name: Naidu - first_name: Pascal A. full_name: Oesch, Pascal A. last_name: Oesch - first_name: Laura full_name: Pentericci, Laura last_name: Pentericci - first_name: Pablo G. full_name: Pérez-González, Pablo G. last_name: Pérez-González - first_name: Jane R. full_name: Rigby, Jane R. last_name: Rigby - first_name: Guido full_name: Roberts-Borsani, Guido last_name: Roberts-Borsani - first_name: Daniel full_name: Schaerer, Daniel last_name: Schaerer - first_name: Alice E. full_name: Shapley, Alice E. last_name: Shapley - first_name: Daniel P. full_name: Stark, Daniel P. last_name: Stark - first_name: Massimo full_name: Stiavelli, Massimo last_name: Stiavelli - first_name: Allison L. full_name: Strom, Allison L. last_name: Strom - first_name: Eros full_name: Vanzella, Eros last_name: Vanzella - first_name: Feige full_name: Wang, Feige last_name: Wang - first_name: Stephen M. full_name: Wilkins, Stephen M. last_name: Wilkins - first_name: Christina C. full_name: Williams, Christina C. last_name: Williams - first_name: Chris J. full_name: Willott, Chris J. last_name: Willott - first_name: Dominika full_name: Wylezalek, Dominika last_name: Wylezalek - first_name: Antonella full_name: Nota, Antonella last_name: Nota citation: ama: Adamo A, Atek H, Bagley MB, et al. The first billion years according to JWST. Nature Astronomy. 2025;9(8):1134-1147. doi:10.1038/s41550-025-02624-5 apa: Adamo, A., Atek, H., Bagley, M. B., Bañados, E., Barrow, K. S. S., Berg, D. A., … Nota, A. (2025). The first billion years according to JWST. Nature Astronomy. Springer Nature. https://doi.org/10.1038/s41550-025-02624-5 chicago: Adamo, Angela, Hakim Atek, Micaela B. Bagley, Eduardo Bañados, Kirk S.S. Barrow, Danielle A. Berg, Rachel Bezanson, et al. “The First Billion Years According to JWST.” Nature Astronomy. Springer Nature, 2025. https://doi.org/10.1038/s41550-025-02624-5. ieee: A. Adamo et al., “The first billion years according to JWST,” Nature Astronomy, vol. 9, no. 8. Springer Nature, pp. 1134–1147, 2025. ista: Adamo A, Atek H, Bagley MB, Bañados E, Barrow KSS, Berg DA, Bezanson R, Bradač M, Brammer G, Carnall AC, Chisholm J, Coe D, Dayal P, Eisenstein DJ, Eldridge JJ, Ferrara A, Fujimoto S, Graaff AD, Habouzit M, Hutchison TA, Kartaltepe JS, Kassin SA, Kriek M, Labbé I, Maiolino R, Marques-Chaves R, Maseda MV, Mason C, Matthee JJ, Mcquinn KBW, Meynet G, Naidu RP, Oesch PA, Pentericci L, Pérez-González PG, Rigby JR, Roberts-Borsani G, Schaerer D, Shapley AE, Stark DP, Stiavelli M, Strom AL, Vanzella E, Wang F, Wilkins SM, Williams CC, Willott CJ, Wylezalek D, Nota A. 2025. The first billion years according to JWST. Nature Astronomy. 9(8), 1134–1147. mla: Adamo, Angela, et al. “The First Billion Years According to JWST.” Nature Astronomy, vol. 9, no. 8, Springer Nature, 2025, pp. 1134–47, doi:10.1038/s41550-025-02624-5. short: A. Adamo, H. Atek, M.B. Bagley, E. Bañados, K.S.S. Barrow, D.A. Berg, R. Bezanson, M. Bradač, G. Brammer, A.C. Carnall, J. Chisholm, D. Coe, P. Dayal, D.J. Eisenstein, J.J. Eldridge, A. Ferrara, S. Fujimoto, A.D. Graaff, M. Habouzit, T.A. Hutchison, J.S. Kartaltepe, S.A. Kassin, M. Kriek, I. Labbé, R. Maiolino, R. Marques-Chaves, M.V. Maseda, C. Mason, J.J. Matthee, K.B.W. Mcquinn, G. Meynet, R.P. Naidu, P.A. Oesch, L. Pentericci, P.G. Pérez-González, J.R. Rigby, G. Roberts-Borsani, D. Schaerer, A.E. Shapley, D.P. Stark, M. Stiavelli, A.L. Strom, E. Vanzella, F. Wang, S.M. Wilkins, C.C. Williams, C.J. Willott, D. Wylezalek, A. Nota, Nature Astronomy 9 (2025) 1134–1147. date_created: 2025-08-31T22:01:32Z date_published: 2025-08-01T00:00:00Z date_updated: 2025-09-30T14:28:42Z day: '01' department: - _id: JoMa doi: 10.1038/s41550-025-02624-5 external_id: arxiv: - '2405.21054' isi: - '001547681400001' intvolume: ' 9' isi: 1 issue: '8' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2405.21054 month: '08' oa: 1 oa_version: Preprint page: 1134-1147 publication: Nature Astronomy publication_identifier: eissn: - 2397-3366 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The first billion years according to JWST type: journal_article user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345 volume: 9 year: '2025' ... --- OA_place: publisher OA_type: gold _id: '20256' abstract: - lang: eng text: We study the problem of predictive runtime monitoring of black-box dynamical systems with quantitative safety properties. The black-box setting stipulates that the exact semantics of the dynamical system and the controller are unknown, and that we are only able to observe the state of the controlled (aka, closed-loop) system at finitely many time points. We present a novel framework for predicting future states of the system based on the states observed in the past. The numbers of past states and of predicted future states are parameters provided by the user. Our method is based on a combination of Taylor’s expansion and the backward difference operator for numerical differentiation. We also derive an upper bound on the prediction error under the assumption that the system dynamics and the controller are smooth. The predicted states are then used to predict safety violations ahead in time. Our experiments demonstrate practical applicability of our method for complex black-box systems, showing that it is computationally lightweight and yet significantly more accurate than the state-of-the-art predictive safety monitoring techniques. acknowledgement: "This work was supported in part by the ERC project ERC-2020-AdG 101020093.\r\n" alternative_title: - PMLR article_processing_charge: No arxiv: 1 author: - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 - first_name: Fabian full_name: Kresse, Fabian id: faff3c84-23f6-11ef-9085-e5187b51c604 last_name: Kresse - first_name: Kaushik full_name: Mallik, Kaushik id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598 last_name: Mallik orcid: 0000-0001-9864-7475 - first_name: Zhengqi full_name: Yu, Zhengqi id: 20aa2ae8-f2f1-11ed-bbfa-8205053f1342 last_name: Yu - first_name: Dorde full_name: Zikelic, Dorde id: 294AA7A6-F248-11E8-B48F-1D18A9856A87 last_name: Zikelic orcid: 0000-0002-4681-1699 citation: ama: 'Henzinger TA, Kresse F, Mallik K, Yu E, Zikelic D. Predictive monitoring of black-box dynamical systems. In: 7th Annual Learning for Dynamics & Control Conference. Vol 283. ML Research Press; 2025:804-816.' apa: 'Henzinger, T. A., Kresse, F., Mallik, K., Yu, E., & Zikelic, D. (2025). Predictive monitoring of black-box dynamical systems. In 7th Annual Learning for Dynamics & Control Conference (Vol. 283, pp. 804–816). Ann Arbor, MI, United States: ML Research Press.' chicago: Henzinger, Thomas A, Fabian Kresse, Kaushik Mallik, Emily Yu, and Dorde Zikelic. “Predictive Monitoring of Black-Box Dynamical Systems.” In 7th Annual Learning for Dynamics & Control Conference, 283:804–16. ML Research Press, 2025. ieee: T. A. Henzinger, F. Kresse, K. Mallik, E. Yu, and D. Zikelic, “Predictive monitoring of black-box dynamical systems,” in 7th Annual Learning for Dynamics & Control Conference, Ann Arbor, MI, United States, 2025, vol. 283, pp. 804–816. ista: 'Henzinger TA, Kresse F, Mallik K, Yu E, Zikelic D. 2025. Predictive monitoring of black-box dynamical systems. 7th Annual Learning for Dynamics & Control Conference. L4DC: Learning for Dynamics & Control, PMLR, vol. 283, 804–816.' mla: Henzinger, Thomas A., et al. “Predictive Monitoring of Black-Box Dynamical Systems.” 7th Annual Learning for Dynamics & Control Conference, vol. 283, ML Research Press, 2025, pp. 804–16. short: T.A. Henzinger, F. Kresse, K. Mallik, E. Yu, D. Zikelic, in:, 7th Annual Learning for Dynamics & Control Conference, ML Research Press, 2025, pp. 804–816. conference: end_date: 2025-06-06 location: Ann Arbor, MI, United States name: 'L4DC: Learning for Dynamics & Control' start_date: 2025-06-04 corr_author: '1' date_created: 2025-08-31T22:01:32Z date_published: 2025-06-01T00:00:00Z date_updated: 2025-09-03T10:37:59Z day: '01' ddc: - '000' department: - _id: ToHe - _id: ChLa ec_funded: 1 external_id: arxiv: - '2412.16564' file: - access_level: open_access checksum: d5236e561560635f5ae1d17de4903033 content_type: application/pdf creator: dernst date_created: 2025-09-03T10:32:12Z date_updated: 2025-09-03T10:32:12Z file_id: '20283' file_name: 2025_L4DC_HenzingerT.pdf file_size: 489639 relation: main_file success: 1 file_date_updated: 2025-09-03T10:32:12Z has_accepted_license: '1' intvolume: ' 283' language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: 804-816 project: - _id: 62781420-2b32-11ec-9570-8d9b63373d4d call_identifier: H2020 grant_number: '101020093' name: Vigilant Algorithmic Monitoring of Software publication: 7th Annual Learning for Dynamics & Control Conference publication_identifier: eissn: - 2640-3498 publication_status: published publisher: ML Research Press quality_controlled: '1' scopus_import: '1' status: public title: Predictive monitoring of black-box dynamical systems type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 283 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20258' abstract: - lang: eng text: The specific introduction of ^1H-^13C or ^1H-^15N moieties into otherwise deuterated proteins holds great potential for high-resolution solution and magic-angle spinning (MAS) NMR studies of protein structure and dynamics. Arginine residues play key roles for example at active sites of enzymes. Taking advantage of a chemically synthesized Arg with a ^13C-^1H2 group in an otherwise deuterated backbone, we demonstrate here the usefulness of proton-detected MAS NMR approaches to probe arginine dynamics. In experiments with crystalline ubiquitin and the 134 kDa tetrameric enzyme malate dehydrogenase we detected a wide range of motions, from sites that are rigid on time scales of at least tens of milliseconds to residues undergoing predominantly nanosecond motions. Spin-relaxation and dipolar-coupling measurements enabled quantitative determination of these dynamics. We observed microsecond dynamics of residue Arg54 in crystalline ubiquitin, whose backbone is known to sample different β-turn conformations on this time scale. The labeling scheme and experiments presented here expand the toolkit for high-resolution proton-detected MAS NMR. acknowledged_ssus: - _id: NMR - _id: LifeSc acknowledgement: This work was supported financially by the Austrian Science Fund (FWF, Grant No. I5812-B, “AlloSpace”). This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility (LSF). We thank Petra Rovò and Margarita Valhondo Falcón for excellent support of the NMR facility. article_number: '169379' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Darja full_name: Rohden, Darja id: 81dc668a-19fa-11f0-bf31-d56534059ef3 last_name: Rohden - first_name: Federico full_name: Napoli, Federico id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b last_name: Napoli orcid: 0000-0002-9043-136X - first_name: Anna full_name: Kapitonova, Anna id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471 last_name: Kapitonova - first_name: Benjamin full_name: Tatman, Benjamin id: 71cda2f3-e604-11ee-a1df-da10587eda3f last_name: Tatman - first_name: Roman J. full_name: Lichtenecker, Roman J. last_name: Lichtenecker - first_name: Paul full_name: Schanda, Paul id: 7B541462-FAF6-11E9-A490-E8DFE5697425 last_name: Schanda orcid: 0000-0002-9350-7606 citation: ama: Rohden D, Napoli F, Kapitonova A, Tatman B, Lichtenecker RJ, Schanda P. Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme. Journal of Molecular Biology. 2025;437(23). doi:10.1016/j.jmb.2025.169379 apa: Rohden, D., Napoli, F., Kapitonova, A., Tatman, B., Lichtenecker, R. J., & Schanda, P. (2025). Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme. Journal of Molecular Biology. Elsevier. https://doi.org/10.1016/j.jmb.2025.169379 chicago: Rohden, Darja, Federico Napoli, Anna Kapitonova, Benjamin Tatman, Roman J. Lichtenecker, and Paul Schanda. “Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme.” Journal of Molecular Biology. Elsevier, 2025. https://doi.org/10.1016/j.jmb.2025.169379. ieee: D. Rohden, F. Napoli, A. Kapitonova, B. Tatman, R. J. Lichtenecker, and P. Schanda, “Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme,” Journal of Molecular Biology, vol. 437, no. 23. Elsevier, 2025. ista: Rohden D, Napoli F, Kapitonova A, Tatman B, Lichtenecker RJ, Schanda P. 2025. Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme. Journal of Molecular Biology. 437(23), 169379. mla: Rohden, Darja, et al. “Arginine Dynamics Probed by Magic-Angle Spinning NMR with a Specific Isotope-Labeling Scheme.” Journal of Molecular Biology, vol. 437, no. 23, 169379, Elsevier, 2025, doi:10.1016/j.jmb.2025.169379. short: D. Rohden, F. Napoli, A. Kapitonova, B. Tatman, R.J. Lichtenecker, P. Schanda, Journal of Molecular Biology 437 (2025). corr_author: '1' date_created: 2025-08-31T22:01:33Z date_published: 2025-12-01T00:00:00Z date_updated: 2026-06-10T08:20:37Z day: '01' ddc: - '540' department: - _id: PaSc doi: 10.1016/j.jmb.2025.169379 external_id: isi: - '001618289100020' file: - access_level: open_access checksum: 90d50594d8ea9860ac5da41297992847 content_type: application/pdf creator: dernst date_created: 2025-12-29T14:51:40Z date_updated: 2025-12-29T14:51:40Z file_id: '20876' file_name: 2025_JourMolecularBiology_Rohden.pdf file_size: 2270555 relation: main_file success: 1 file_date_updated: 2025-12-29T14:51:40Z has_accepted_license: '1' intvolume: ' 437' isi: 1 issue: '23' language: - iso: eng month: '12' oa: 1 oa_version: Published Version project: - _id: eb9c82eb-77a9-11ec-83b8-aadd536561cf grant_number: I05812 name: AlloSpace. The emergence and mechanisms of allostery publication: Journal of Molecular Biology publication_identifier: eissn: - 1089-8638 issn: - 0022-2836 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: record: - id: '19956' relation: research_data status: public scopus_import: '1' status: public title: Arginine dynamics probed by magic-angle spinning NMR with a specific isotope-labeling scheme tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 437 year: '2025' ... --- OA_type: closed access _id: '20259' abstract: - lang: eng text: Cell migration in narrow microenvironments occurs in numerous physiological processes. It involves successive cycles of confinement and release that drive important morphological changes. However, it remains unclear whether migrating cells can retain a memory of their past morphological states that could potentially facilitate their navigation through confined spaces. We demonstrate that local geometry governs a switch between two cell morphologies, thereby facilitating cell passage through long and narrow gaps. We combined cell migration assays on standardized microsystems with biophysical modelling and biochemical perturbations to show that migrating cells have a long-term memory of past confinement events. The morphological cell states correlate across transitions through actin cortex remodelling. These findings indicate that mechanical memory in migrating cells plays an active role in their migratory potential in confined environments. acknowledgement: We are grateful to members of S.G.’s laboratory for feedback and suggestions. We thank E. Hannezo, J. O. Rädler, M. Piel, O. du Roure and J. Heuvingh for inspiring discussions. Y.K. and S.G. acknowledge J. B. Braquenier from Nikon Instruments Belux and the Nikon BioImaging Lab in Leiden (the Netherlands) for their support with the Nikon Spatial Array Confocal enhanced-resolution confocal microscopy. We thank D. S. Herrador and M. Balland for their help in improving the microprinting method. D.B.B. was supported by the NOMIS Foundation as a NOMIS Fellow and by an EMBO Postdoctoral Fellowship (ALTF 343-2022). Y.K., M.L. and S.G. acknowledge funding from the University of Mons (FEDER Prostem Research Project no. 1510614, Wallonia DG06), the F.R.S.-FNRS (Epiforce Project no. T.0092.21, Cellsqueezer Project no. J.0061.23 and Optopattern Project no. U.NO26.22) and the Interreg projects ANTIRESI and MICROPLAITE, which are financially supported by Interreg France-Wallonie-Vlaanderen (Fonds Européen de Développement Régional). Y.K. and M.L. are financially supported by F.R.S.-FNRS as FRIA Grantee FNRS and Postdoctoral Fellow (Chargé de Recherches), respectively. Y.K. and S.G. acknowledge le Fonds pour la Recherche Médicale dans le Hainaut (FRMH). G.C. was supported by a grant from the Biotechnology and Biological Sciences Research Council (grant no. BB/V007483/1). article_processing_charge: No article_type: original author: - first_name: Yohalie full_name: Kalukula, Yohalie last_name: Kalukula - first_name: Marine full_name: Luciano, Marine last_name: Luciano - first_name: Gleb full_name: Simanov, Gleb last_name: Simanov - first_name: Guillaume full_name: Charras, Guillaume last_name: Charras - first_name: David full_name: Brückner, David id: e1e86031-6537-11eb-953a-f7ab92be508d last_name: Brückner orcid: 0000-0001-7205-2975 - first_name: Sylvain full_name: Gabriele, Sylvain last_name: Gabriele citation: ama: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. The actin cortex acts as a mechanical memory of morphology in confined migrating cells. Nature Physics. 2025;21:1451-1461. doi:10.1038/s41567-025-02980-z apa: Kalukula, Y., Luciano, M., Simanov, G., Charras, G., Brückner, D., & Gabriele, S. (2025). The actin cortex acts as a mechanical memory of morphology in confined migrating cells. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-02980-z chicago: Kalukula, Yohalie, Marine Luciano, Gleb Simanov, Guillaume Charras, David Brückner, and Sylvain Gabriele. “The Actin Cortex Acts as a Mechanical Memory of Morphology in Confined Migrating Cells.” Nature Physics. Springer Nature, 2025. https://doi.org/10.1038/s41567-025-02980-z. ieee: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, and S. Gabriele, “The actin cortex acts as a mechanical memory of morphology in confined migrating cells,” Nature Physics, vol. 21. Springer Nature, pp. 1451–1461, 2025. ista: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. 2025. The actin cortex acts as a mechanical memory of morphology in confined migrating cells. Nature Physics. 21, 1451–1461. mla: Kalukula, Yohalie, et al. “The Actin Cortex Acts as a Mechanical Memory of Morphology in Confined Migrating Cells.” Nature Physics, vol. 21, Springer Nature, 2025, pp. 1451–61, doi:10.1038/s41567-025-02980-z. short: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, S. Gabriele, Nature Physics 21 (2025) 1451–1461. corr_author: '1' date_created: 2025-08-31T22:01:33Z date_published: 2025-09-01T00:00:00Z date_updated: 2025-12-30T09:34:11Z day: '01' department: - _id: EdHa doi: 10.1038/s41567-025-02980-z external_id: isi: - '001556019400001' intvolume: ' 21' isi: 1 language: - iso: eng month: '09' oa_version: None page: 1451-1461 project: - _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b grant_number: ALTF 343-2022 name: A mechano-chemical theory for stem cell fate decisions in organoid development publication: Nature Physics publication_identifier: eissn: - 1745-2481 issn: - 1745-2473 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: The actin cortex acts as a mechanical memory of morphology in confined migrating cells type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 21 year: '2025' ...