---
_id: '7752'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: Jill G.
  full_name: Pilkington, Jill G.
  last_name: Pilkington
- first_name: Tim H.
  full_name: Clutton-Brock, Tim H.
  last_name: Clutton-Brock
- first_name: Josephine M.
  full_name: Pemberton, Josephine M.
  last_name: Pemberton
- first_name: Loeske. E.B.
  full_name: Kruuk, Loeske. E.B.
  last_name: Kruuk
citation:
  ama: Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. Environmental
    heterogeneity generates fluctuating selection on a secondary sexual trait. <i>Current
    Biology</i>. 2008;18(10):751-757. doi:<a href="https://doi.org/10.1016/j.cub.2008.04.059">10.1016/j.cub.2008.04.059</a>
  apa: Robinson, M. R., Pilkington, J. G., Clutton-Brock, T. H., Pemberton, J. M.,
    &#38; Kruuk, L. E. B. (2008). Environmental heterogeneity generates fluctuating
    selection on a secondary sexual trait. <i>Current Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.cub.2008.04.059">https://doi.org/10.1016/j.cub.2008.04.059</a>
  chicago: Robinson, Matthew Richard, Jill G. Pilkington, Tim H. Clutton-Brock, Josephine
    M. Pemberton, and Loeske. E.B. Kruuk. “Environmental Heterogeneity Generates Fluctuating
    Selection on a Secondary Sexual Trait.” <i>Current Biology</i>. Elsevier, 2008.
    <a href="https://doi.org/10.1016/j.cub.2008.04.059">https://doi.org/10.1016/j.cub.2008.04.059</a>.
  ieee: M. R. Robinson, J. G. Pilkington, T. H. Clutton-Brock, J. M. Pemberton, and
    L. E. B. Kruuk, “Environmental heterogeneity generates fluctuating selection on
    a secondary sexual trait,” <i>Current Biology</i>, vol. 18, no. 10. Elsevier,
    pp. 751–757, 2008.
  ista: Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. 2008.
    Environmental heterogeneity generates fluctuating selection on a secondary sexual
    trait. Current Biology. 18(10), 751–757.
  mla: Robinson, Matthew Richard, et al. “Environmental Heterogeneity Generates Fluctuating
    Selection on a Secondary Sexual Trait.” <i>Current Biology</i>, vol. 18, no. 10,
    Elsevier, 2008, pp. 751–57, doi:<a href="https://doi.org/10.1016/j.cub.2008.04.059">10.1016/j.cub.2008.04.059</a>.
  short: M.R. Robinson, J.G. Pilkington, T.H. Clutton-Brock, J.M. Pemberton, L.E.B.
    Kruuk, Current Biology 18 (2008) 751–757.
date_created: 2020-04-30T11:02:13Z
date_published: 2008-05-20T00:00:00Z
date_updated: 2021-01-12T08:15:17Z
day: '20'
doi: 10.1016/j.cub.2008.04.059
extern: '1'
intvolume: '        18'
issue: '10'
language:
- iso: eng
month: '05'
oa_version: None
page: 751-757
publication: Current Biology
publication_identifier:
  issn:
  - 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Environmental heterogeneity generates fluctuating selection on a secondary
  sexual trait
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2008'
...
---
_id: '844'
abstract:
- lang: eng
  text: Mutation rate varies greatly between nucleotide sites of the human genome
    and depends both on the global genomic location and the local sequence context
    of a site. In particular, CpG context elevates the mutation rate by an order of
    magnitude. Mutations also vary widely in their effect on the molecular function,
    phenotype, and fitness. Independence of the probability of occurrence of a new
    mutation's effect has been a fundamental premise in genetics. However, highly
    mutable contexts may be preserved by negative selection at important sites but
    destroyed by mutation at sites under no selection. Thus, there may be a positive
    correlation between the rate of mutations at a nucleotide site and the magnitude
    of their effect on fitness. We studied the impact of CpG context on the rate of
    human-chimpanzee divergence and on intrahuman nucleotide diversity at non-synonymous
    coding sites. We compared nucleotides that occupy identical positions within codons
    of identical amino acids and only differ by being within versus outside CpG context.
    Nucleotides within CpG context are under a stronger negative selection, as revealed
    by their lower, proportionally to the mutation rate, rate of evolution and nucleotide
    diversity. In particular, the probability of fixation of a non-synonymous transition
    at a CpG site is two times lower than at a CpG site. Thus, sites with different
    mutation rates are not necessarily selectively equivalent. This suggests that
    the mutation rate may complement sequence conservation as a characteristic predictive
    of functional importance of nucleotide sites.
acknowledgement: This work was supported in part by NIH grants R01 GM078598 and U54
  LM008748.
author:
- first_name: Steffen
  full_name: Schmidt, Steffen
  last_name: Schmidt
- first_name: Anna
  full_name: Gerasimova, Anna
  last_name: Gerasimova
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Ivan
  full_name: Adzuhbei, Ivan A
  last_name: Adzuhbei
- first_name: Alexey
  full_name: Kondrashov, Alexey S
  last_name: Kondrashov
- first_name: Shamil
  full_name: Sunyaev, Shamil R
  last_name: Sunyaev
citation:
  ama: Schmidt S, Gerasimova A, Kondrashov F, Adzuhbei I, Kondrashov A, Sunyaev S.
    Hypermutable non-synonymous sites are under stronger negative selection. <i>PLoS
    Genetics</i>. 2008;4(11). doi:<a href="https://doi.org/10.1371/journal.pgen.1000281">10.1371/journal.pgen.1000281</a>
  apa: Schmidt, S., Gerasimova, A., Kondrashov, F., Adzuhbei, I., Kondrashov, A.,
    &#38; Sunyaev, S. (2008). Hypermutable non-synonymous sites are under stronger
    negative selection. <i>PLoS Genetics</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1000281">https://doi.org/10.1371/journal.pgen.1000281</a>
  chicago: Schmidt, Steffen, Anna Gerasimova, Fyodor Kondrashov, Ivan Adzuhbei, Alexey
    Kondrashov, and Shamil Sunyaev. “Hypermutable Non-Synonymous Sites Are under Stronger
    Negative Selection.” <i>PLoS Genetics</i>. Public Library of Science, 2008. <a
    href="https://doi.org/10.1371/journal.pgen.1000281">https://doi.org/10.1371/journal.pgen.1000281</a>.
  ieee: S. Schmidt, A. Gerasimova, F. Kondrashov, I. Adzuhbei, A. Kondrashov, and
    S. Sunyaev, “Hypermutable non-synonymous sites are under stronger negative selection,”
    <i>PLoS Genetics</i>, vol. 4, no. 11. Public Library of Science, 2008.
  ista: Schmidt S, Gerasimova A, Kondrashov F, Adzuhbei I, Kondrashov A, Sunyaev S.
    2008. Hypermutable non-synonymous sites are under stronger negative selection.
    PLoS Genetics. 4(11).
  mla: Schmidt, Steffen, et al. “Hypermutable Non-Synonymous Sites Are under Stronger
    Negative Selection.” <i>PLoS Genetics</i>, vol. 4, no. 11, Public Library of Science,
    2008, doi:<a href="https://doi.org/10.1371/journal.pgen.1000281">10.1371/journal.pgen.1000281</a>.
  short: S. Schmidt, A. Gerasimova, F. Kondrashov, I. Adzuhbei, A. Kondrashov, S.
    Sunyaev, PLoS Genetics 4 (2008).
date_created: 2018-12-11T11:48:48Z
date_published: 2008-11-01T00:00:00Z
date_updated: 2021-01-12T08:19:16Z
day: '01'
doi: 10.1371/journal.pgen.1000281
extern: 1
intvolume: '         4'
issue: '11'
month: '11'
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '6800'
quality_controlled: 0
status: public
title: Hypermutable non-synonymous sites are under stronger negative selection
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 4
year: '2008'
...
---
_id: '8480'
abstract:
- lang: eng
  text: The KIX domain of the transcription co-activator CBP is a three-helix bundle
    protein that folds via rapid accumulation of an intermediate state, followed by
    a slower folding phase. Recent NMR relaxation dispersion studies revealed the
    presence of a low-populated (excited) state of KIX that exists in equilibrium
    with the natively folded form under non-denaturing conditions, and likely represents
    the equilibrium analog of the folding intermediate. Here, we combine amide hydrogen/deuterium
    exchange measurements using rapid NMR data acquisition techniques with backbone
    15N and 13C relaxation dispersion experiments to further investigate the equilibrium
    folding of the KIX domain. Residual structure within the folding intermediate
    is detected by both methods, and their combination enables reliable quantification
    of the amount of persistent residual structure. Three well-defined folding subunits
    are found, which display variable stability and correspond closely to the individual
    helices in the native state. While two of the three helices (α2 and α3) are partially
    formed in the folding intermediate (to ∼ 50% and ∼ 80%, respectively, at 20 °C),
    the third helix is disordered. The observed helical content within the excited
    state exceeds the helical propensities predicted for the corresponding peptide
    regions, suggesting that the two helices are weakly mutually stabilized, while
    methyl 13C relaxation dispersion data indicate that a defined packing arrangement
    is unlikely. Temperature-dependent experiments reveal that the largest enthalpy
    and entropy changes along the folding reaction occur during the final transition
    from the intermediate to the native state. Our experimental data are consistent
    with a folding mechanism where helices α2 and α3 form rapidly, although to different
    extents, while helix α1 consolidates only as folding proceeds to complete the
    native state-structure.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
- first_name: Robert
  full_name: Konrat, Robert
  last_name: Konrat
- first_name: Martin
  full_name: Tollinger, Martin
  last_name: Tollinger
citation:
  ama: 'Schanda P, Brutscher B, Konrat R, Tollinger M. Folding of the KIX domain:
    Characterization of the equilibrium analog of a folding intermediate using 15N/13C
    relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy. <i>Journal
    of Molecular Biology</i>. 2008;380(4):726-741. doi:<a href="https://doi.org/10.1016/j.jmb.2008.05.040">10.1016/j.jmb.2008.05.040</a>'
  apa: 'Schanda, P., Brutscher, B., Konrat, R., &#38; Tollinger, M. (2008). Folding
    of the KIX domain: Characterization of the equilibrium analog of a folding intermediate
    using 15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy.
    <i>Journal of Molecular Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jmb.2008.05.040">https://doi.org/10.1016/j.jmb.2008.05.040</a>'
  chicago: 'Schanda, Paul, Bernhard Brutscher, Robert Konrat, and Martin Tollinger.
    “Folding of the KIX Domain: Characterization of the Equilibrium Analog of a Folding
    Intermediate Using 15N/13C Relaxation Dispersion and Fast 1H/2H Amide Exchange
    NMR Spectroscopy.” <i>Journal of Molecular Biology</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.jmb.2008.05.040">https://doi.org/10.1016/j.jmb.2008.05.040</a>.'
  ieee: 'P. Schanda, B. Brutscher, R. Konrat, and M. Tollinger, “Folding of the KIX
    domain: Characterization of the equilibrium analog of a folding intermediate using
    15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy,”
    <i>Journal of Molecular Biology</i>, vol. 380, no. 4. Elsevier, pp. 726–741, 2008.'
  ista: 'Schanda P, Brutscher B, Konrat R, Tollinger M. 2008. Folding of the KIX domain:
    Characterization of the equilibrium analog of a folding intermediate using 15N/13C
    relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy. Journal
    of Molecular Biology. 380(4), 726–741.'
  mla: 'Schanda, Paul, et al. “Folding of the KIX Domain: Characterization of the
    Equilibrium Analog of a Folding Intermediate Using 15N/13C Relaxation Dispersion
    and Fast 1H/2H Amide Exchange NMR Spectroscopy.” <i>Journal of Molecular Biology</i>,
    vol. 380, no. 4, Elsevier, 2008, pp. 726–41, doi:<a href="https://doi.org/10.1016/j.jmb.2008.05.040">10.1016/j.jmb.2008.05.040</a>.'
  short: P. Schanda, B. Brutscher, R. Konrat, M. Tollinger, Journal of Molecular Biology
    380 (2008) 726–741.
date_created: 2020-09-18T10:12:29Z
date_published: 2008-07-18T00:00:00Z
date_updated: 2021-01-12T08:19:34Z
day: '18'
doi: 10.1016/j.jmb.2008.05.040
extern: '1'
intvolume: '       380'
issue: '4'
keyword:
- Molecular Biology
language:
- iso: eng
month: '07'
oa_version: None
page: 726-741
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Folding of the KIX domain: Characterization of the equilibrium analog of a
  folding intermediate using 15N/13C relaxation dispersion and fast 1H/2H amide exchange
  NMR spectroscopy'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 380
year: '2008'
...
---
_id: '8481'
abstract:
- lang: eng
  text: 'The copK gene is localized on the pMOL30 plasmid of Cupriavidus metallidurans
    CH34 within the complex cop cluster of genes, for which 21 genes have been identified.
    The expression of the corresponding periplasmic CopK protein is strongly upregulated
    in the presence of copper, leading to a high periplasmic accumulation. The structure
    and metal-binding properties of CopK were investigated by NMR and mass spectrometry.
    The protein is dimeric in the apo state with a dissociation constant in the range
    of 10- 5 M estimated from analytical ultracentrifugation. Mass spectrometry revealed
    that CopK has two high-affinity Cu(I)-binding sites per monomer with different
    Cu(I) affinities. Binding of Cu(II) was observed but appeared to be non-specific.
    The solution structure of apo-CopK revealed an all-β fold formed of two β-sheets
    in perpendicular orientation with an unstructured C-terminal tail. The dimer interface
    is formed by the surface of the C-terminal β-sheet. Binding of the first Cu(I)-ion
    induces a major structural modification involving dissociation of the dimeric
    apo-protein. Backbone chemical shifts determined for the 1Cu(I)-bound form confirm
    the conservation of the N-terminal β-sheet, while the last strand of the C-terminal
    sheet appears in slow conformational exchange. We hypothesize that the partial
    disruption of the C-terminal β-sheet is related to dimer dissociation. NH-exchange
    data acquired on the apo-protein are consistent with a lower thermodynamic stability
    of the C-terminal sheet. CopK contains seven methionine residues, five of which
    appear highly conserved. Chemical shift data suggest implication of two or three
    methionines (Met54, Met38, Met28) in the first Cu(I) site. Addition of a second
    Cu(I) ion further increases protein plasticity. Comparison of the structural and
    metal-binding properties of CopK with other periplasmic copper-binding proteins
    reveals two conserved features within these functionally related proteins: the
    all-β fold and the methionine-rich Cu(I)-binding site.'
article_processing_charge: No
article_type: original
author:
- first_name: Beate
  full_name: Bersch, Beate
  last_name: Bersch
- first_name: Adrien
  full_name: Favier, Adrien
  last_name: Favier
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Sébastien
  full_name: van Aelst, Sébastien
  last_name: van Aelst
- first_name: Tatiana
  full_name: Vallaeys, Tatiana
  last_name: Vallaeys
- first_name: Jacques
  full_name: Covès, Jacques
  last_name: Covès
- first_name: Max
  full_name: Mergeay, Max
  last_name: Mergeay
- first_name: Ruddy
  full_name: Wattiez, Ruddy
  last_name: Wattiez
citation:
  ama: Bersch B, Favier A, Schanda P, et al. Molecular structure and metal-binding
    properties of the periplasmic CopK protein expressed in Cupriavidus metallidurans
    CH34 during copper challenge. <i>Journal of Molecular Biology</i>. 2008;380(2):386-403.
    doi:<a href="https://doi.org/10.1016/j.jmb.2008.05.017">10.1016/j.jmb.2008.05.017</a>
  apa: Bersch, B., Favier, A., Schanda, P., van Aelst, S., Vallaeys, T., Covès, J.,
    … Wattiez, R. (2008). Molecular structure and metal-binding properties of the
    periplasmic CopK protein expressed in Cupriavidus metallidurans CH34 during copper
    challenge. <i>Journal of Molecular Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jmb.2008.05.017">https://doi.org/10.1016/j.jmb.2008.05.017</a>
  chicago: Bersch, Beate, Adrien Favier, Paul Schanda, Sébastien van Aelst, Tatiana
    Vallaeys, Jacques Covès, Max Mergeay, and Ruddy Wattiez. “Molecular Structure
    and Metal-Binding Properties of the Periplasmic CopK Protein Expressed in Cupriavidus
    Metallidurans CH34 during Copper Challenge.” <i>Journal of Molecular Biology</i>.
    Elsevier, 2008. <a href="https://doi.org/10.1016/j.jmb.2008.05.017">https://doi.org/10.1016/j.jmb.2008.05.017</a>.
  ieee: B. Bersch <i>et al.</i>, “Molecular structure and metal-binding properties
    of the periplasmic CopK protein expressed in Cupriavidus metallidurans CH34 during
    copper challenge,” <i>Journal of Molecular Biology</i>, vol. 380, no. 2. Elsevier,
    pp. 386–403, 2008.
  ista: Bersch B, Favier A, Schanda P, van Aelst S, Vallaeys T, Covès J, Mergeay M,
    Wattiez R. 2008. Molecular structure and metal-binding properties of the periplasmic
    CopK protein expressed in Cupriavidus metallidurans CH34 during copper challenge.
    Journal of Molecular Biology. 380(2), 386–403.
  mla: Bersch, Beate, et al. “Molecular Structure and Metal-Binding Properties of
    the Periplasmic CopK Protein Expressed in Cupriavidus Metallidurans CH34 during
    Copper Challenge.” <i>Journal of Molecular Biology</i>, vol. 380, no. 2, Elsevier,
    2008, pp. 386–403, doi:<a href="https://doi.org/10.1016/j.jmb.2008.05.017">10.1016/j.jmb.2008.05.017</a>.
  short: B. Bersch, A. Favier, P. Schanda, S. van Aelst, T. Vallaeys, J. Covès, M.
    Mergeay, R. Wattiez, Journal of Molecular Biology 380 (2008) 386–403.
date_created: 2020-09-18T10:12:37Z
date_published: 2008-07-04T00:00:00Z
date_updated: 2021-01-12T08:19:34Z
day: '04'
doi: 10.1016/j.jmb.2008.05.017
extern: '1'
intvolume: '       380'
issue: '2'
keyword:
- Molecular Biology
language:
- iso: eng
month: '07'
oa_version: None
page: 386-403
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Molecular structure and metal-binding properties of the periplasmic CopK protein
  expressed in Cupriavidus metallidurans CH34 during copper challenge
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 380
year: '2008'
...
---
_id: '8482'
abstract:
- lang: eng
  text: The SOFAST-HMQC experiment [P. Schanda, B. Brutscher, Very fast two-dimensional
    NMR spectroscopy for real-time investigation of dynamic events in proteins on
    the time scale of seconds, J. Am. Chem. Soc. 127 (2005) 8014–8015] allows recording
    two-dimensional correlation spectra of macromolecules such as proteins in only
    a few seconds acquisition time. To achieve the highest possible sensitivity, SOFAST-HMQC
    experiments are preferably performed on high-field NMR spectrometers equipped
    with cryogenically cooled probes. The duty cycle of over 80% in fast-pulsing SOFAST-HMQC
    experiments, however, may cause problems when using a cryogenic probe. Here we
    introduce SE-IPAP-SOFAST-HMQC, a new pulse sequence that provides comparable sensitivity
    to standard SOFAST-HMQC, while avoiding heteronuclear decoupling during 1H detection,
    and thus significantly reducing the radiofrequency load of the probe during the
    experiment. The experiment is also attractive for fast and sensitive measurement
    of heteronuclear one-bond spin coupling constants.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Thomas
  full_name: Kern, Thomas
  last_name: Kern
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
citation:
  ama: Kern T, Schanda P, Brutscher B. Sensitivity-enhanced IPAP-SOFAST-HMQC for fast-pulsing
    2D NMR with reduced radiofrequency load. <i>Journal of Magnetic Resonance</i>.
    2008;190(2):333-338. doi:<a href="https://doi.org/10.1016/j.jmr.2007.11.015">10.1016/j.jmr.2007.11.015</a>
  apa: Kern, T., Schanda, P., &#38; Brutscher, B. (2008). Sensitivity-enhanced IPAP-SOFAST-HMQC
    for fast-pulsing 2D NMR with reduced radiofrequency load. <i>Journal of Magnetic
    Resonance</i>. Elsevier. <a href="https://doi.org/10.1016/j.jmr.2007.11.015">https://doi.org/10.1016/j.jmr.2007.11.015</a>
  chicago: Kern, Thomas, Paul Schanda, and Bernhard Brutscher. “Sensitivity-Enhanced
    IPAP-SOFAST-HMQC for Fast-Pulsing 2D NMR with Reduced Radiofrequency Load.” <i>Journal
    of Magnetic Resonance</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.jmr.2007.11.015">https://doi.org/10.1016/j.jmr.2007.11.015</a>.
  ieee: T. Kern, P. Schanda, and B. Brutscher, “Sensitivity-enhanced IPAP-SOFAST-HMQC
    for fast-pulsing 2D NMR with reduced radiofrequency load,” <i>Journal of Magnetic
    Resonance</i>, vol. 190, no. 2. Elsevier, pp. 333–338, 2008.
  ista: Kern T, Schanda P, Brutscher B. 2008. Sensitivity-enhanced IPAP-SOFAST-HMQC
    for fast-pulsing 2D NMR with reduced radiofrequency load. Journal of Magnetic
    Resonance. 190(2), 333–338.
  mla: Kern, Thomas, et al. “Sensitivity-Enhanced IPAP-SOFAST-HMQC for Fast-Pulsing
    2D NMR with Reduced Radiofrequency Load.” <i>Journal of Magnetic Resonance</i>,
    vol. 190, no. 2, Elsevier, 2008, pp. 333–38, doi:<a href="https://doi.org/10.1016/j.jmr.2007.11.015">10.1016/j.jmr.2007.11.015</a>.
  short: T. Kern, P. Schanda, B. Brutscher, Journal of Magnetic Resonance 190 (2008)
    333–338.
date_created: 2020-09-18T10:12:46Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T08:19:35Z
day: '01'
doi: 10.1016/j.jmr.2007.11.015
extern: '1'
intvolume: '       190'
issue: '2'
keyword:
- Nuclear and High Energy Physics
- Biophysics
- Biochemistry
- Condensed Matter Physics
language:
- iso: eng
month: '02'
oa_version: None
page: 333-338
publication: Journal of Magnetic Resonance
publication_identifier:
  issn:
  - 1090-7807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Sensitivity-enhanced IPAP-SOFAST-HMQC for fast-pulsing 2D NMR with reduced
  radiofrequency load
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 190
year: '2008'
...
---
_id: '8509'
abstract:
- lang: eng
  text: The goal of this paper is to present to nonspecialists what is perhaps the
    simplest possible geometrical picture explaining the mechanism of Arnold diffusion.
    We choose to speak of a specific model—that of geometric rays in a periodic optical
    medium. This model is equivalent to that of a particle in a periodic potential
    in ${\mathbb R}^{n}$ with energy prescribed and to the geodesic flow in a Riemannian
    metric on ${\mathbb R}^{n} $.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
- first_name: Mark
  full_name: Levi, Mark
  last_name: Levi
citation:
  ama: Kaloshin V, Levi M. Geometry of Arnold diffusion. <i>SIAM Review</i>. 2008;50(4):702-720.
    doi:<a href="https://doi.org/10.1137/070703235">10.1137/070703235</a>
  apa: Kaloshin, V., &#38; Levi, M. (2008). Geometry of Arnold diffusion. <i>SIAM
    Review</i>. Society for Industrial &#38; Applied Mathematics. <a href="https://doi.org/10.1137/070703235">https://doi.org/10.1137/070703235</a>
  chicago: Kaloshin, Vadim, and Mark Levi. “Geometry of Arnold Diffusion.” <i>SIAM
    Review</i>. Society for Industrial &#38; Applied Mathematics, 2008. <a href="https://doi.org/10.1137/070703235">https://doi.org/10.1137/070703235</a>.
  ieee: V. Kaloshin and M. Levi, “Geometry of Arnold diffusion,” <i>SIAM Review</i>,
    vol. 50, no. 4. Society for Industrial &#38; Applied Mathematics, pp. 702–720,
    2008.
  ista: Kaloshin V, Levi M. 2008. Geometry of Arnold diffusion. SIAM Review. 50(4),
    702–720.
  mla: Kaloshin, Vadim, and Mark Levi. “Geometry of Arnold Diffusion.” <i>SIAM Review</i>,
    vol. 50, no. 4, Society for Industrial &#38; Applied Mathematics, 2008, pp. 702–20,
    doi:<a href="https://doi.org/10.1137/070703235">10.1137/070703235</a>.
  short: V. Kaloshin, M. Levi, SIAM Review 50 (2008) 702–720.
date_created: 2020-09-18T10:48:12Z
date_published: 2008-11-05T00:00:00Z
date_updated: 2021-01-12T08:19:46Z
day: '05'
doi: 10.1137/070703235
extern: '1'
intvolume: '        50'
issue: '4'
keyword:
- Theoretical Computer Science
- Applied Mathematics
- Computational Mathematics
language:
- iso: eng
month: '11'
oa_version: None
page: 702-720
publication: SIAM Review
publication_identifier:
  issn:
  - 0036-1445
  - 1095-7200
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
status: public
title: Geometry of Arnold diffusion
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2008'
...
---
_id: '8510'
abstract:
- lang: eng
  text: In this paper, using the ideas of Bessi and Mather, we present a simple mechanical
    system exhibiting Arnold diffusion. This system of a particle in a small periodic
    potential can be also interpreted as ray propagation in a periodic optical medium
    with a near-constant index of refraction. Arnold diffusion in this context manifests
    itself as an arbitrary finite change of direction for nearly constant index of
    refraction.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
- first_name: Mark
  full_name: Levi, Mark
  last_name: Levi
citation:
  ama: Kaloshin V, Levi M. An example of Arnold diffusion for near-integrable Hamiltonians.
    <i>Bulletin of the American Mathematical Society</i>. 2008;45(3):409-427. doi:<a
    href="https://doi.org/10.1090/s0273-0979-08-01211-1">10.1090/s0273-0979-08-01211-1</a>
  apa: Kaloshin, V., &#38; Levi, M. (2008). An example of Arnold diffusion for near-integrable
    Hamiltonians. <i>Bulletin of the American Mathematical Society</i>. American Mathematical
    Society. <a href="https://doi.org/10.1090/s0273-0979-08-01211-1">https://doi.org/10.1090/s0273-0979-08-01211-1</a>
  chicago: Kaloshin, Vadim, and Mark Levi. “An Example of Arnold Diffusion for Near-Integrable
    Hamiltonians.” <i>Bulletin of the American Mathematical Society</i>. American
    Mathematical Society, 2008. <a href="https://doi.org/10.1090/s0273-0979-08-01211-1">https://doi.org/10.1090/s0273-0979-08-01211-1</a>.
  ieee: V. Kaloshin and M. Levi, “An example of Arnold diffusion for near-integrable
    Hamiltonians,” <i>Bulletin of the American Mathematical Society</i>, vol. 45,
    no. 3. American Mathematical Society, pp. 409–427, 2008.
  ista: Kaloshin V, Levi M. 2008. An example of Arnold diffusion for near-integrable
    Hamiltonians. Bulletin of the American Mathematical Society. 45(3), 409–427.
  mla: Kaloshin, Vadim, and Mark Levi. “An Example of Arnold Diffusion for Near-Integrable
    Hamiltonians.” <i>Bulletin of the American Mathematical Society</i>, vol. 45,
    no. 3, American Mathematical Society, 2008, pp. 409–27, doi:<a href="https://doi.org/10.1090/s0273-0979-08-01211-1">10.1090/s0273-0979-08-01211-1</a>.
  short: V. Kaloshin, M. Levi, Bulletin of the American Mathematical Society 45 (2008)
    409–427.
date_created: 2020-09-18T10:48:20Z
date_published: 2008-07-01T00:00:00Z
date_updated: 2021-01-12T08:19:47Z
day: '01'
doi: 10.1090/s0273-0979-08-01211-1
extern: '1'
intvolume: '        45'
issue: '3'
keyword:
- Applied Mathematics
- General Mathematics
language:
- iso: eng
month: '07'
oa_version: None
page: 409-427
publication: Bulletin of the American Mathematical Society
publication_identifier:
  issn:
  - 0273-0979
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: An example of Arnold diffusion for near-integrable Hamiltonians
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2008'
...
---
_id: '895'
abstract:
- lang: eng
  text: Background. The arginine vasopressin V1a receptor (V1aR) modulates social
    cognition and behavior in a wide variety of species. Variation in a repetitive
    microsatellite element in the 5′ flanking region of the V1aR gene (AVPR1A) in
    rodents has been associated with variation in brain V1aR expression and in social
    behavior. In humans, the 5′ flanking region of AVPR1A contains a tandem duplication
    of two ∼350 bp, microsatellite-containing elements located approximately 3.5 kb
    upstream of the transcription start site. The first block, referred to as DupA,
    contains a polymorphic (GT) 25microsatellite; the second block, DupB, has a complex
    (CT) 4-(TT)-(CT)8-(GT)24polymorphic motif, known as RS3. Polymorphisms in RS3
    have been associated with variation in sociobehavioral traits in humans, including
    autism spectrum disorders. Thus, evolution of these regions may have contributed
    to variation in social behavior in primates. We examined the structure of these
    regions in six ape, six monkey, and one prosimian species. Results. Both tandem
    repeat blocks are present upstream of the AVPR1A coding region in five of the
    ape species we investigated, while monkeys have only one copy of this region.
    As in humans, the microsatellites within DupA and DupB are polymorphic in many
    primate species. Furthermore, both single (lacking DupB) and duplicated alleles
    (containing both DupA and DupB) are present in chimpanzee (Pan troglodytes) populations
    with allele frequencies of 0.795 and 0.205 for the single and duplicated alleles,
    respectively, based on the analysis of 47 wild-caught individuals. Finally, a
    phylogenetic reconstruction suggests two alternate evolutionary histories for
    this locus. Conclusion. There is no obvious relationship between the presence
    of the RS3 duplication and social organization in primates. However, polymorphisms
    identified in some species may be useful in future genetic association studies.
    In particular, the presence of both single and duplicated alleles in chimpanzees
    provides a unique opportunity to assess the functional role of this duplication
    in contributing to variation in social behavior in primates. While our initial
    studies show no signs of directional selection on this locus in chimps, pharmacological
    and genetic association studies support a potential role for this region in influencing
    V1aR expression and social behavior.
acknowledgement: |
  We thank the caretakers at Zoo Atlanta and Yerkes National Primate Center for help with procuring specimens. Additional DNA samples were supplied by Bill Hopkins, Emory University (chimpanzee), Allyson Bennet, Wake Forest University (chimpanzee, rhesus macaque, bonnet macaque), Mar Sanchez, Emory University (rhesus macaque), and Anne Yoder, Duke University (galago). Susan Lambeth, M.D. Anderson Cancer Center, and Katie Chace, Yerkes National Primate Center, helped provide records regarding the origins of wild born chimps at these centers. We would like to thank Dr Lisa McGraw and two anonymous reviewers for their com- ments on this manuscript. This work was supported by NSF IBN-9876754, NIH RR00165, NIMH56897 (LJY), MH64692 (LJY) and a Howard Hughes Predoctoral Fellowship (ZRD).
author:
- first_name: Zoe
  full_name: Donaldson, Zoe R
  last_name: Donaldson
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Andrea
  full_name: Putnam, Andrea S
  last_name: Putnam
- first_name: Yaohui
  full_name: Bai, Yaohui
  last_name: Bai
- first_name: Tara
  full_name: Stoinski, Tara S
  last_name: Stoinski
- first_name: Elizabeth
  full_name: Hammock, Elizabeth A
  last_name: Hammock
- first_name: Larry
  full_name: Young, Larry
  last_name: Young
citation:
  ama: Donaldson Z, Kondrashov F, Putnam A, et al. Evolution of a behavior-linked
    microsatellite-containing element in the 5′ flanking region of the primate AVPR1A
    gene. <i>BMC Evolutionary Biology</i>. 2008;8(1). doi:<a href="https://doi.org/10.1186/1471-2148-8-180">10.1186/1471-2148-8-180</a>
  apa: Donaldson, Z., Kondrashov, F., Putnam, A., Bai, Y., Stoinski, T., Hammock,
    E., &#38; Young, L. (2008). Evolution of a behavior-linked microsatellite-containing
    element in the 5′ flanking region of the primate AVPR1A gene. <i>BMC Evolutionary
    Biology</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2148-8-180">https://doi.org/10.1186/1471-2148-8-180</a>
  chicago: Donaldson, Zoe, Fyodor Kondrashov, Andrea Putnam, Yaohui Bai, Tara Stoinski,
    Elizabeth Hammock, and Larry Young. “Evolution of a Behavior-Linked Microsatellite-Containing
    Element in the 5′ Flanking Region of the Primate AVPR1A Gene.” <i>BMC Evolutionary
    Biology</i>. BioMed Central, 2008. <a href="https://doi.org/10.1186/1471-2148-8-180">https://doi.org/10.1186/1471-2148-8-180</a>.
  ieee: Z. Donaldson <i>et al.</i>, “Evolution of a behavior-linked microsatellite-containing
    element in the 5′ flanking region of the primate AVPR1A gene,” <i>BMC Evolutionary
    Biology</i>, vol. 8, no. 1. BioMed Central, 2008.
  ista: Donaldson Z, Kondrashov F, Putnam A, Bai Y, Stoinski T, Hammock E, Young L.
    2008. Evolution of a behavior-linked microsatellite-containing element in the
    5′ flanking region of the primate AVPR1A gene. BMC Evolutionary Biology. 8(1).
  mla: Donaldson, Zoe, et al. “Evolution of a Behavior-Linked Microsatellite-Containing
    Element in the 5′ Flanking Region of the Primate AVPR1A Gene.” <i>BMC Evolutionary
    Biology</i>, vol. 8, no. 1, BioMed Central, 2008, doi:<a href="https://doi.org/10.1186/1471-2148-8-180">10.1186/1471-2148-8-180</a>.
  short: Z. Donaldson, F. Kondrashov, A. Putnam, Y. Bai, T. Stoinski, E. Hammock,
    L. Young, BMC Evolutionary Biology 8 (2008).
date_created: 2018-12-11T11:49:04Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T08:21:29Z
day: '01'
doi: 10.1186/1471-2148-8-180
extern: 1
intvolume: '         8'
issue: '1'
month: '01'
publication: BMC Evolutionary Biology
publication_status: published
publisher: BioMed Central
publist_id: '6753'
quality_controlled: 0
status: public
title: Evolution of a behavior-linked microsatellite-containing element in the 5′
  flanking region of the primate AVPR1A gene
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 8
year: '2008'
...
---
_id: '907'
abstract:
- lang: eng
  text: The most common form of protein-coding gene overlap in eukaryotes is a simple
    nested structure, whereby one gene is embedded in an intron of another. Analysis
    of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed
    substantially higher rates of evolutionary gains than losses. The accumulation
    of nested gene structures could not be attributed to any obvious functional relationships
    between the genes involved and represents an increase of the organizational complexity
    of animal genomes via a neutral process.
author:
- first_name: Raquel
  full_name: Assis, Raquel
  last_name: Assis
- first_name: Alexey
  full_name: Kondrashov, Alexey S
  last_name: Kondrashov
- first_name: Eugene
  full_name: Koonin, Eugene V
  last_name: Koonin
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Assis R, Kondrashov A, Koonin E, Kondrashov F. Nested genes and increasing
    organizational complexity of metazoan genomes. <i>Trends in Genetics</i>. 2008;24(10):475-478.
    doi:<a href="https://doi.org/10.1016/j.tig.2008.08.003">10.1016/j.tig.2008.08.003</a>
  apa: Assis, R., Kondrashov, A., Koonin, E., &#38; Kondrashov, F. (2008). Nested
    genes and increasing organizational complexity of metazoan genomes. <i>Trends
    in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2008.08.003">https://doi.org/10.1016/j.tig.2008.08.003</a>
  chicago: Assis, Raquel, Alexey Kondrashov, Eugene Koonin, and Fyodor Kondrashov.
    “Nested Genes and Increasing Organizational Complexity of Metazoan Genomes.” <i>Trends
    in Genetics</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.tig.2008.08.003">https://doi.org/10.1016/j.tig.2008.08.003</a>.
  ieee: R. Assis, A. Kondrashov, E. Koonin, and F. Kondrashov, “Nested genes and increasing
    organizational complexity of metazoan genomes,” <i>Trends in Genetics</i>, vol.
    24, no. 10. Elsevier, pp. 475–478, 2008.
  ista: Assis R, Kondrashov A, Koonin E, Kondrashov F. 2008. Nested genes and increasing
    organizational complexity of metazoan genomes. Trends in Genetics. 24(10), 475–478.
  mla: Assis, Raquel, et al. “Nested Genes and Increasing Organizational Complexity
    of Metazoan Genomes.” <i>Trends in Genetics</i>, vol. 24, no. 10, Elsevier, 2008,
    pp. 475–78, doi:<a href="https://doi.org/10.1016/j.tig.2008.08.003">10.1016/j.tig.2008.08.003</a>.
  short: R. Assis, A. Kondrashov, E. Koonin, F. Kondrashov, Trends in Genetics 24
    (2008) 475–478.
date_created: 2018-12-11T11:49:08Z
date_published: 2008-10-01T00:00:00Z
date_updated: 2021-01-12T08:21:49Z
day: '01'
doi: 10.1016/j.tig.2008.08.003
extern: 1
intvolume: '        24'
issue: '10'
month: '10'
page: 475 - 478
publication: Trends in Genetics
publication_status: published
publisher: Elsevier
publist_id: '6743'
quality_controlled: 0
status: public
title: Nested genes and increasing organizational complexity of metazoan genomes
type: journal_article
volume: 24
year: '2008'
...
---
_id: '9457'
abstract:
- lang: eng
  text: Eukaryotic chromatin is separated into functional domains differentiated by
    posttranslational histone modifications, histone variants, and DNA methylation1–6.
    Methylation is associated with repression of transcriptional initiation in plants
    and animals, and is frequently found in transposable elements. Proper methylation
    patterns are critical for eukaryotic development4,5, and aberrant methylation-induced
    silencing of tumor suppressor genes is a common feature of human cancer7. In contrast
    to methylation, the histone variant H2A.Z is preferentially deposited by the Swr1
    ATPase complex near 5′ ends of genes where it promotes transcriptional competence8–20.
    How DNA methylation and H2A.Z influence transcription remains largely unknown.
    Here we show that in the plant Arabidopsis thaliana, regions of DNA methylation
    are quantitatively deficient in H2A.Z. Exclusion of H2A.Z is seen at sites of
    DNA methylation in the bodies of actively transcribed genes and in methylated
    transposons. Mutation of the MET1 DNA methyltransferase, which causes both losses
    and gains of DNA methylation4,5, engenders opposite changes in H2A.Z deposition,
    while mutation of the PIE1 subunit of the Swr1 complex that deposits H2A.Z17 leads
    to genome-wide hypermethylation. Our findings indicate that DNA methylation can
    influence chromatin structure and effect gene silencing by excluding H2A.Z, and
    that H2A.Z protects genes from DNA methylation.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: Devin
  full_name: Coleman-Derr, Devin
  last_name: Coleman-Derr
- first_name: Tracy
  full_name: Ballinger, Tracy
  last_name: Ballinger
- first_name: Steven
  full_name: Henikoff, Steven
  last_name: Henikoff
citation:
  ama: Zilberman D, Coleman-Derr D, Ballinger T, Henikoff S. Histone H2A.Z and DNA
    methylation are mutually antagonistic chromatin marks. <i>Nature</i>. 2008;456(7218):125-129.
    doi:<a href="https://doi.org/10.1038/nature07324">10.1038/nature07324</a>
  apa: Zilberman, D., Coleman-Derr, D., Ballinger, T., &#38; Henikoff, S. (2008).
    Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. <i>Nature</i>.
    Springer Nature. <a href="https://doi.org/10.1038/nature07324">https://doi.org/10.1038/nature07324</a>
  chicago: Zilberman, Daniel, Devin Coleman-Derr, Tracy Ballinger, and Steven Henikoff.
    “Histone H2A.Z and DNA Methylation Are Mutually Antagonistic Chromatin Marks.”
    <i>Nature</i>. Springer Nature, 2008. <a href="https://doi.org/10.1038/nature07324">https://doi.org/10.1038/nature07324</a>.
  ieee: D. Zilberman, D. Coleman-Derr, T. Ballinger, and S. Henikoff, “Histone H2A.Z
    and DNA methylation are mutually antagonistic chromatin marks,” <i>Nature</i>,
    vol. 456, no. 7218. Springer Nature, pp. 125–129, 2008.
  ista: Zilberman D, Coleman-Derr D, Ballinger T, Henikoff S. 2008. Histone H2A.Z
    and DNA methylation are mutually antagonistic chromatin marks. Nature. 456(7218),
    125–129.
  mla: Zilberman, Daniel, et al. “Histone H2A.Z and DNA Methylation Are Mutually Antagonistic
    Chromatin Marks.” <i>Nature</i>, vol. 456, no. 7218, Springer Nature, 2008, pp.
    125–29, doi:<a href="https://doi.org/10.1038/nature07324">10.1038/nature07324</a>.
  short: D. Zilberman, D. Coleman-Derr, T. Ballinger, S. Henikoff, Nature 456 (2008)
    125–129.
date_created: 2021-06-04T11:49:32Z
date_published: 2008-11-06T00:00:00Z
date_updated: 2021-12-14T08:54:36Z
day: '06'
department:
- _id: DaZi
doi: 10.1038/nature07324
extern: '1'
external_id:
  pmid:
  - '18815594'
intvolume: '       456'
issue: '7218'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877514/
month: '11'
oa: 1
oa_version: Submitted Version
page: 125-129
pmid: 1
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 456
year: '2008'
...
---
_id: '9537'
abstract:
- lang: eng
  text: DNA methylation is an ancient process found in all domains of life. Although
    the enzymes that mediate methylation have remained highly conserved, DNA methylation
    has been adapted for a variety of uses throughout evolution, including defense
    against transposable elements and control of gene expression. Defects in DNA methylation
    are linked to human diseases, including cancer. Methylation has been lost several
    times in the course of animal and fungal evolution, thus limiting the opportunity
    for study in common model organisms. In the past decade, plants have emerged as
    a premier model system for genetic dissection of DNA methylation. A recent combination
    of plant genetics with powerful genomic approaches has led to a number of exciting
    discoveries and promises many more.
article_processing_charge: No
article_type: review
author:
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Zilberman D. The evolving functions of DNA methylation. <i>Current Opinion
    in Plant Biology</i>. 2008;11(5):554-559. doi:<a href="https://doi.org/10.1016/j.pbi.2008.07.004">10.1016/j.pbi.2008.07.004</a>
  apa: Zilberman, D. (2008). The evolving functions of DNA methylation. <i>Current
    Opinion in Plant Biology</i>. Elsevier . <a href="https://doi.org/10.1016/j.pbi.2008.07.004">https://doi.org/10.1016/j.pbi.2008.07.004</a>
  chicago: Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current
    Opinion in Plant Biology</i>. Elsevier , 2008. <a href="https://doi.org/10.1016/j.pbi.2008.07.004">https://doi.org/10.1016/j.pbi.2008.07.004</a>.
  ieee: D. Zilberman, “The evolving functions of DNA methylation,” <i>Current Opinion
    in Plant Biology</i>, vol. 11, no. 5. Elsevier , pp. 554–559, 2008.
  ista: Zilberman D. 2008. The evolving functions of DNA methylation. Current Opinion
    in Plant Biology. 11(5), 554–559.
  mla: Zilberman, Daniel. “The Evolving Functions of DNA Methylation.” <i>Current
    Opinion in Plant Biology</i>, vol. 11, no. 5, Elsevier , 2008, pp. 554–59, doi:<a
    href="https://doi.org/10.1016/j.pbi.2008.07.004">10.1016/j.pbi.2008.07.004</a>.
  short: D. Zilberman, Current Opinion in Plant Biology 11 (2008) 554–559.
date_created: 2021-06-08T13:13:37Z
date_published: 2008-10-01T00:00:00Z
date_updated: 2021-12-14T08:54:07Z
department:
- _id: DaZi
doi: 10.1016/j.pbi.2008.07.004
extern: '1'
external_id:
  pmid:
  - '18774331'
intvolume: '        11'
issue: '5'
language:
- iso: eng
month: '10'
oa_version: None
page: 554-559
pmid: 1
publication: Current Opinion in Plant Biology
publication_identifier:
  issn:
  - 1369-5266
publication_status: published
publisher: 'Elsevier '
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolving functions of DNA methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 11
year: '2008'
...
---
_id: '965'
abstract:
- lang: eng
  text: We give many examples of applying Bogoliubov's forest formula to iterative
    solutions of various nonlinear equations. The same formula describes an extremely
    wide class of objects, from an ordinary quadratic equation to renormalization
    in quantum field theory.
acknowledgement: |-
  This work is supported in part by the Dynasty Foundation (M. N. S.),  the
  Russian Foundation for Basic Research (Grant No
  s. 07-02-00878 and 07-02-00645), a joint grant (Grant
  No. 06-01-92059-CE), the NWO (Project No. 047.011.2004.026), INTAS (Grant No. 05-1000008-7865), the
  Program for Supporting Leading Scientific School
  s (Grant No. NSh-8004.2006.2), and also by a project
  (Project No. ANR-05-BLAN-0029-01, A. Yu. M.).
author:
- first_name: Alexei
  full_name: Morozov, Alexei Y
  last_name: Morozov
- first_name: Maksym
  full_name: Maksym Serbyn
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Morozov A, Serbyn M. Nonlinear algebra and Bogoliubov’s recursion. <i>Theoretical
    and Mathematical Physics</i>. 2008;154(2):270-293. doi:<a href="https://doi.org/10.1007/s11232-008-0026-7">10.1007/s11232-008-0026-7</a>
  apa: Morozov, A., &#38; Serbyn, M. (2008). Nonlinear algebra and Bogoliubov’s recursion.
    <i>Theoretical and Mathematical Physics</i>. Elsevier. <a href="https://doi.org/10.1007/s11232-008-0026-7">https://doi.org/10.1007/s11232-008-0026-7</a>
  chicago: Morozov, Alexei, and Maksym Serbyn. “Nonlinear Algebra and Bogoliubov’s
    Recursion.” <i>Theoretical and Mathematical Physics</i>. Elsevier, 2008. <a href="https://doi.org/10.1007/s11232-008-0026-7">https://doi.org/10.1007/s11232-008-0026-7</a>.
  ieee: A. Morozov and M. Serbyn, “Nonlinear algebra and Bogoliubov’s recursion,”
    <i>Theoretical and Mathematical Physics</i>, vol. 154, no. 2. Elsevier, pp. 270–293,
    2008.
  ista: Morozov A, Serbyn M. 2008. Nonlinear algebra and Bogoliubov’s recursion. Theoretical
    and Mathematical Physics. 154(2), 270–293.
  mla: Morozov, Alexei, and Maksym Serbyn. “Nonlinear Algebra and Bogoliubov’s Recursion.”
    <i>Theoretical and Mathematical Physics</i>, vol. 154, no. 2, Elsevier, 2008,
    pp. 270–93, doi:<a href="https://doi.org/10.1007/s11232-008-0026-7">10.1007/s11232-008-0026-7</a>.
  short: A. Morozov, M. Serbyn, Theoretical and Mathematical Physics 154 (2008) 270–293.
date_created: 2018-12-11T11:49:26Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T08:22:17Z
day: '01'
doi: 10.1007/s11232-008-0026-7
extern: 1
intvolume: '       154'
issue: '2'
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/hep-th/0703258
month: '01'
oa: 1
page: 270 - 293
publication: Theoretical and Mathematical Physics
publication_status: published
publisher: Elsevier
publist_id: '6437'
quality_controlled: 0
status: public
title: Nonlinear algebra and Bogoliubov's recursion
type: journal_article
volume: 154
year: '2008'
...
---
_id: '517'
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Barton NH. Identity and coalescence in structured populations: A commentary
    on “Inbreeding coefficients and coalescence times” by Montgomery Slatkin. <i>Genetics
    Research</i>. 2008;89(5-6):475-477. doi:<a href="https://doi.org/10.1017/S0016672308009683">10.1017/S0016672308009683</a>'
  apa: 'Barton, N. H. (2008). Identity and coalescence in structured populations:
    A commentary on “Inbreeding coefficients and coalescence times” by Montgomery
    Slatkin. <i>Genetics Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672308009683">https://doi.org/10.1017/S0016672308009683</a>'
  chicago: 'Barton, Nicholas H. “Identity and Coalescence in Structured Populations:
    A Commentary on ‘Inbreeding Coefficients and Coalescence Times’ by Montgomery
    Slatkin.” <i>Genetics Research</i>. Cambridge University Press, 2008. <a href="https://doi.org/10.1017/S0016672308009683">https://doi.org/10.1017/S0016672308009683</a>.'
  ieee: 'N. H. Barton, “Identity and coalescence in structured populations: A commentary
    on ‘Inbreeding coefficients and coalescence times’ by Montgomery Slatkin,” <i>Genetics
    Research</i>, vol. 89, no. 5–6. Cambridge University Press, pp. 475–477, 2008.'
  ista: 'Barton NH. 2008. Identity and coalescence in structured populations: A commentary
    on ‘Inbreeding coefficients and coalescence times’ by Montgomery Slatkin. Genetics
    Research. 89(5–6), 475–477.'
  mla: 'Barton, Nicholas H. “Identity and Coalescence in Structured Populations: A
    Commentary on ‘Inbreeding Coefficients and Coalescence Times’ by Montgomery Slatkin.”
    <i>Genetics Research</i>, vol. 89, no. 5–6, Cambridge University Press, 2008,
    pp. 475–77, doi:<a href="https://doi.org/10.1017/S0016672308009683">10.1017/S0016672308009683</a>.'
  short: N.H. Barton, Genetics Research 89 (2008) 475–477.
date_created: 2018-12-11T11:46:55Z
date_published: 2008-10-29T00:00:00Z
date_updated: 2025-09-30T09:56:56Z
day: '29'
department:
- _id: NiBa
doi: 10.1017/S0016672308009683
external_id:
  isi:
  - '000207048900023'
intvolume: '        89'
isi: 1
issue: 5-6
language:
- iso: eng
month: '10'
oa_version: None
page: 475 - 477
publication: Genetics Research
publication_status: published
publisher: Cambridge University Press
publist_id: '7302'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Identity and coalescence in structured populations: A commentary on ''Inbreeding
  coefficients and coalescence times'' by Montgomery Slatkin'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 89
year: '2008'
...
---
_id: '581'
abstract:
- lang: eng
  text: We have detected a spin-dependent displacement perpendicular to the refractive
    index gradient for photons passing through an air-glass interface. The effect
    is the photonic version of the spin Hall effect in electronic systems, indicating
    the universality of the effect for particles of different nature. Treating the
    effect as a weak measurement of the spin projection of the photons, we used a
    preselection and postselection technique on the spin state to enhance the original
    displacement by nearly four orders of magnitude, attaining sensitivity to displacements
    of ∼1 angstrom. The spin Hall effect can be used for manipulating photonic angular
    momentum states, and the measurement technique holds promise for precision metrology.
author:
- first_name: Onur
  full_name: Onur Hosten
  id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
  last_name: Hosten
  orcid: 0000-0002-2031-204X
- first_name: Paul
  full_name: Kwiat, Paul
  last_name: Kwiat
citation:
  ama: Hosten O, Kwiat P. Observation of the spin hall effect of light via weak measurements.
    <i>Science</i>. 2008;319(5864):787-790. doi:<a href="https://doi.org/10.1126/science.1152697">10.1126/science.1152697</a>
  apa: Hosten, O., &#38; Kwiat, P. (2008). Observation of the spin hall effect of
    light via weak measurements. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.1152697">https://doi.org/10.1126/science.1152697</a>
  chicago: Hosten, Onur, and Paul Kwiat. “Observation of the Spin Hall Effect of Light
    via Weak Measurements.” <i>Science</i>. American Association for the Advancement
    of Science, 2008. <a href="https://doi.org/10.1126/science.1152697">https://doi.org/10.1126/science.1152697</a>.
  ieee: O. Hosten and P. Kwiat, “Observation of the spin hall effect of light via
    weak measurements,” <i>Science</i>, vol. 319, no. 5864. American Association for
    the Advancement of Science, pp. 787–790, 2008.
  ista: Hosten O, Kwiat P. 2008. Observation of the spin hall effect of light via
    weak measurements. Science. 319(5864), 787–790.
  mla: Hosten, Onur, and Paul Kwiat. “Observation of the Spin Hall Effect of Light
    via Weak Measurements.” <i>Science</i>, vol. 319, no. 5864, American Association
    for the Advancement of Science, 2008, pp. 787–90, doi:<a href="https://doi.org/10.1126/science.1152697">10.1126/science.1152697</a>.
  short: O. Hosten, P. Kwiat, Science 319 (2008) 787–790.
date_created: 2018-12-11T11:47:19Z
date_published: 2008-02-08T00:00:00Z
date_updated: 2021-01-12T08:03:38Z
day: '08'
doi: 10.1126/science.1152697
extern: 1
intvolume: '       319'
issue: '5864'
month: '02'
page: 787 - 790
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '7226'
quality_controlled: 0
status: public
title: Observation of the spin hall effect of light via weak measurements
type: journal_article
volume: 319
year: '2008'
...
---
_id: '584'
abstract:
- lang: eng
  text: Using “quantum weak-measurements” as a coherent enhancement technique for
    small signals, we have measured the recently proposed “spin Hall effect” of light
    at an air-glass interface, and are working on the smoothly varying refractive-index
    case.
alternative_title:
- Optics InfoBase Conference Papers
article_processing_charge: No
author:
- first_name: Onur
  full_name: Hosten, Onur
  id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
  last_name: Hosten
  orcid: 0000-0002-2031-204X
- first_name: Paul
  full_name: Kwiat, Paul
  last_name: Kwiat
citation:
  ama: 'Hosten O, Kwiat P. Spin hall effect of light via weak measurements: Sharp
    and smooth index variations. In: Optica Publishing Group; 2008.'
  apa: 'Hosten, O., &#38; Kwiat, P. (2008). Spin hall effect of light via weak measurements:
    Sharp and smooth index variations. Presented at the QELS: Quantum Electronics
    and Laser Science Conference, San Jose, CA, United States: Optica Publishing Group.'
  chicago: 'Hosten, Onur, and Paul Kwiat. “Spin Hall Effect of Light via Weak Measurements:
    Sharp and Smooth Index Variations.” Optica Publishing Group, 2008.'
  ieee: 'O. Hosten and P. Kwiat, “Spin hall effect of light via weak measurements:
    Sharp and smooth index variations,” presented at the QELS: Quantum Electronics
    and Laser Science Conference, San Jose, CA, United States, 2008.'
  ista: 'Hosten O, Kwiat P. 2008. Spin hall effect of light via weak measurements:
    Sharp and smooth index variations. QELS: Quantum Electronics and Laser Science
    Conference, Optics InfoBase Conference Papers, .'
  mla: 'Hosten, Onur, and Paul Kwiat. <i>Spin Hall Effect of Light via Weak Measurements:
    Sharp and Smooth Index Variations</i>. Optica Publishing Group, 2008.'
  short: O. Hosten, P. Kwiat, in:, Optica Publishing Group, 2008.
conference:
  end_date: 2008-05-09
  location: San Jose, CA, United States
  name: 'QELS: Quantum Electronics and Laser Science Conference'
  start_date: 2008-05-04
corr_author: '1'
date_created: 2018-12-11T11:47:20Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2024-10-09T20:53:53Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://opg.optica.org/abstract.cfm?URI=QELS-2008-QFB7
month: '01'
oa_version: None
publication_identifier:
  isbn:
  - 978-155752859-9
  issn:
  - '21622701'
publication_status: published
publisher: Optica Publishing Group
publist_id: '7227'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spin hall effect of light via weak measurements: Sharp and smooth index variations'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2008'
...
---
_id: '6146'
abstract:
- lang: eng
  text: Homeostasis of internal carbon dioxide (CO2) and oxygen (O2) levels is fundamental
    to all animals. Here we examine the CO2 response of the nematode Caenorhabditis
    elegans. This species inhabits rotting material, which typically has a broad CO2
    concentration range. We show that well fed C. elegans avoid CO2 levels above 0.5%.
    Animals can respond to both absolute CO2 concentrations and changes in CO2 levels
    within seconds. Responses to CO2 do not reflect avoidance of acid pH but appear
    to define a new sensory response. Sensation of CO2 is promoted by the cGMP-gated
    ion channel subunits TAX-2 and TAX-4, but other pathways are also important. Robust
    CO2 avoidance in well fed animals requires inhibition of the DAF-16 forkhead transcription
    factor by the insulin-like receptor DAF-2. Starvation, which activates DAF-16,
    strongly suppresses CO2 avoidance. Exposure to hypoxia (<1% O2) also suppresses
    CO2 avoidance via activation of the hypoxia-inducible transcription factor HIF-1.
    The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1,
    besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes
    avoidance of high CO2. C. elegans integrates competing O2 and CO2 sensory inputs
    so that one response dominates. Food and allelic variation at NPR-1 regulate which
    response prevails. Our results suggest that multiple sensory inputs are coordinated
    by C. elegans to generate different coherent foraging strategies.
author:
- first_name: A. J.
  full_name: Bretscher, A. J.
  last_name: Bretscher
- first_name: K. E.
  full_name: Busch, K. E.
  last_name: Busch
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: Bretscher AJ, Busch KE, de Bono M. A carbon dioxide avoidance behavior is integrated
    with responses to ambient oxygen and food in Caenorhabditis elegans. <i>Proceedings
    of the National Academy of Sciences</i>. 2008;105(23):8044-8049. doi:<a href="https://doi.org/10.1073/pnas.0707607105">10.1073/pnas.0707607105</a>
  apa: Bretscher, A. J., Busch, K. E., &#38; de Bono, M. (2008). A carbon dioxide
    avoidance behavior is integrated with responses to ambient oxygen and food in
    Caenorhabditis elegans. <i>Proceedings of the National Academy of Sciences</i>.
    Proceedings of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.0707607105">https://doi.org/10.1073/pnas.0707607105</a>
  chicago: Bretscher, A. J., K. E. Busch, and Mario de Bono. “A Carbon Dioxide Avoidance
    Behavior Is Integrated with Responses to Ambient Oxygen and Food in Caenorhabditis
    Elegans.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings
    of the National Academy of Sciences, 2008. <a href="https://doi.org/10.1073/pnas.0707607105">https://doi.org/10.1073/pnas.0707607105</a>.
  ieee: A. J. Bretscher, K. E. Busch, and M. de Bono, “A carbon dioxide avoidance
    behavior is integrated with responses to ambient oxygen and food in Caenorhabditis
    elegans,” <i>Proceedings of the National Academy of Sciences</i>, vol. 105, no.
    23. Proceedings of the National Academy of Sciences, pp. 8044–8049, 2008.
  ista: Bretscher AJ, Busch KE, de Bono M. 2008. A carbon dioxide avoidance behavior
    is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.
    Proceedings of the National Academy of Sciences. 105(23), 8044–8049.
  mla: Bretscher, A. J., et al. “A Carbon Dioxide Avoidance Behavior Is Integrated
    with Responses to Ambient Oxygen and Food in Caenorhabditis Elegans.” <i>Proceedings
    of the National Academy of Sciences</i>, vol. 105, no. 23, Proceedings of the
    National Academy of Sciences, 2008, pp. 8044–49, doi:<a href="https://doi.org/10.1073/pnas.0707607105">10.1073/pnas.0707607105</a>.
  short: A.J. Bretscher, K.E. Busch, M. de Bono, Proceedings of the National Academy
    of Sciences 105 (2008) 8044–8049.
date_created: 2019-03-21T08:10:15Z
date_published: 2008-06-10T00:00:00Z
date_updated: 2021-01-12T08:06:21Z
day: '10'
ddc:
- '570'
doi: 10.1073/pnas.0707607105
extern: '1'
external_id:
  pmid:
  - '18524954'
file:
- access_level: open_access
  checksum: eac0413064b022c1489f7b6719e7228c
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-03-21T08:14:54Z
  date_updated: 2020-07-14T12:47:20Z
  file_id: '6147'
  file_name: 2008_PNAS_Bretscher.pdf
  file_size: 501506
  relation: main_file
file_date_updated: 2020-07-14T12:47:20Z
has_accepted_license: '1'
intvolume: '       105'
issue: '23'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 8044-8049
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  issn:
  - 0027-8424
  - 1091-6490
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
status: public
title: A carbon dioxide avoidance behavior is integrated with responses to ambient
  oxygen and food in Caenorhabditis elegans
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 105
year: '2008'
...
---
_id: '6148'
author:
- first_name: Jan E.
  full_name: Kammenga, Jan E.
  last_name: Kammenga
- first_name: Patrick C.
  full_name: Phillips, Patrick C.
  last_name: Phillips
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Agnieszka
  full_name: Doroszuk, Agnieszka
  last_name: Doroszuk
citation:
  ama: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. Beyond induced mutants: using
    worms to study natural variation in genetic pathways. <i>Trends in Genetics</i>.
    2008;24(4):178-185. doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>'
  apa: 'Kammenga, J. E., Phillips, P. C., de Bono, M., &#38; Doroszuk, A. (2008).
    Beyond induced mutants: using worms to study natural variation in genetic pathways.
    <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>'
  chicago: 'Kammenga, Jan E., Patrick C. Phillips, Mario de Bono, and Agnieszka Doroszuk.
    “Beyond Induced Mutants: Using Worms to Study Natural Variation in Genetic Pathways.”
    <i>Trends in Genetics</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>.'
  ieee: 'J. E. Kammenga, P. C. Phillips, M. de Bono, and A. Doroszuk, “Beyond induced
    mutants: using worms to study natural variation in genetic pathways,” <i>Trends
    in Genetics</i>, vol. 24, no. 4. Elsevier, pp. 178–185, 2008.'
  ista: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. 2008. Beyond induced mutants:
    using worms to study natural variation in genetic pathways. Trends in Genetics.
    24(4), 178–185.'
  mla: 'Kammenga, Jan E., et al. “Beyond Induced Mutants: Using Worms to Study Natural
    Variation in Genetic Pathways.” <i>Trends in Genetics</i>, vol. 24, no. 4, Elsevier,
    2008, pp. 178–85, doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>.'
  short: J.E. Kammenga, P.C. Phillips, M. de Bono, A. Doroszuk, Trends in Genetics
    24 (2008) 178–185.
date_created: 2019-03-21T08:19:45Z
date_published: 2008-04-01T00:00:00Z
date_updated: 2021-01-12T08:06:21Z
day: '01'
doi: 10.1016/j.tig.2008.01.001
extern: '1'
external_id:
  pmid:
  - '18325626'
intvolume: '        24'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 178-185
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Beyond induced mutants: using worms to study natural variation in genetic
  pathways'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2008'
...
---
_id: '6149'
article_processing_charge: No
author:
- first_name: Birgitta
  full_name: Olofsson, Birgitta
  last_name: Olofsson
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: 'Olofsson B, de Bono M. Sleep: dozy worms and sleepy flies. <i>Current Biology</i>.
    2008;18(5):R204-R206. doi:<a href="https://doi.org/10.1016/j.cub.2008.01.002">10.1016/j.cub.2008.01.002</a>'
  apa: 'Olofsson, B., &#38; de Bono, M. (2008). Sleep: dozy worms and sleepy flies.
    <i>Current Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.cub.2008.01.002">https://doi.org/10.1016/j.cub.2008.01.002</a>'
  chicago: 'Olofsson, Birgitta, and Mario de Bono. “Sleep: Dozy Worms and Sleepy Flies.”
    <i>Current Biology</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.cub.2008.01.002">https://doi.org/10.1016/j.cub.2008.01.002</a>.'
  ieee: 'B. Olofsson and M. de Bono, “Sleep: dozy worms and sleepy flies,” <i>Current
    Biology</i>, vol. 18, no. 5. Elsevier, pp. R204–R206, 2008.'
  ista: 'Olofsson B, de Bono M. 2008. Sleep: dozy worms and sleepy flies. Current
    Biology. 18(5), R204–R206.'
  mla: 'Olofsson, Birgitta, and Mario de Bono. “Sleep: Dozy Worms and Sleepy Flies.”
    <i>Current Biology</i>, vol. 18, no. 5, Elsevier, 2008, pp. R204–06, doi:<a href="https://doi.org/10.1016/j.cub.2008.01.002">10.1016/j.cub.2008.01.002</a>.'
  short: B. Olofsson, M. de Bono, Current Biology 18 (2008) R204–R206.
date_created: 2019-03-21T08:23:24Z
date_published: 2008-03-11T00:00:00Z
date_updated: 2022-08-25T15:03:41Z
day: '11'
doi: 10.1016/j.cub.2008.01.002
extern: '1'
external_id:
  pmid:
  - '18334193'
intvolume: '        18'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: None
page: R204-R206
pmid: 1
publication: Current Biology
publication_identifier:
  issn:
  - 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Sleep: dozy worms and sleepy flies'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2008'
...
---
_id: '7320'
abstract:
- lang: eng
  text: A comparative, experimental diffusivity study of gas diffusion layer (GDL)
    materials for polymer electrolyte fuel cells (PEFC) is presented for the first
    time. The GDL plays an important role for electrochemical losses due to gas transport
    limitations at high current densities. Characterization and optimization of these
    layers is therefore essential to improve power density. A recently developed method
    which allows for fast diffusimetry is applied and data compared to the literature
    values. Measurements are made as a function of direction and compression and the
    effect of different binder structures and hydrophobic treatments on effective
    diffusivities are discussed. A better understanding of the results is gained by
    including novel GDL cross-section images and a meaningful unit cell model for
    the interpretation of the data. The diffusivity data is valuable for GDL manufacturers
    and future PEFC models. The study reveals that a binder–fiber ratio larger than
    50% has a negative impact on the effective diffusion properties. The hydrophobic
    treatment which is necessary to improve the water management can impede diffusion
    and thus reduce the power density. Furthermore binder has an isotropic effect
    while compression pronounces the in-plane orientation of the fibers.
article_processing_charge: No
article_type: original
author:
- first_name: Reto
  full_name: Flückiger, Reto
  last_name: Flückiger
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Denis
  full_name: Kramer, Denis
  last_name: Kramer
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Günther G.
  full_name: Scherer, Günther G.
  last_name: Scherer
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Flückiger R, Freunberger SA, Kramer D, Wokaun A, Scherer GG, Büchi FN. Anisotropic,
    effective diffusivity of porous gas diffusion layer materials for PEFC. <i>Electrochimica
    Acta</i>. 2008;54(2):551-559. doi:<a href="https://doi.org/10.1016/j.electacta.2008.07.034">10.1016/j.electacta.2008.07.034</a>
  apa: Flückiger, R., Freunberger, S. A., Kramer, D., Wokaun, A., Scherer, G. G.,
    &#38; Büchi, F. N. (2008). Anisotropic, effective diffusivity of porous gas diffusion
    layer materials for PEFC. <i>Electrochimica Acta</i>. Elsevier. <a href="https://doi.org/10.1016/j.electacta.2008.07.034">https://doi.org/10.1016/j.electacta.2008.07.034</a>
  chicago: Flückiger, Reto, Stefan Alexander Freunberger, Denis Kramer, Alexander
    Wokaun, Günther G. Scherer, and Felix N. Büchi. “Anisotropic, Effective Diffusivity
    of Porous Gas Diffusion Layer Materials for PEFC.” <i>Electrochimica Acta</i>.
    Elsevier, 2008. <a href="https://doi.org/10.1016/j.electacta.2008.07.034">https://doi.org/10.1016/j.electacta.2008.07.034</a>.
  ieee: R. Flückiger, S. A. Freunberger, D. Kramer, A. Wokaun, G. G. Scherer, and
    F. N. Büchi, “Anisotropic, effective diffusivity of porous gas diffusion layer
    materials for PEFC,” <i>Electrochimica Acta</i>, vol. 54, no. 2. Elsevier, pp.
    551–559, 2008.
  ista: Flückiger R, Freunberger SA, Kramer D, Wokaun A, Scherer GG, Büchi FN. 2008.
    Anisotropic, effective diffusivity of porous gas diffusion layer materials for
    PEFC. Electrochimica Acta. 54(2), 551–559.
  mla: Flückiger, Reto, et al. “Anisotropic, Effective Diffusivity of Porous Gas Diffusion
    Layer Materials for PEFC.” <i>Electrochimica Acta</i>, vol. 54, no. 2, Elsevier,
    2008, pp. 551–59, doi:<a href="https://doi.org/10.1016/j.electacta.2008.07.034">10.1016/j.electacta.2008.07.034</a>.
  short: R. Flückiger, S.A. Freunberger, D. Kramer, A. Wokaun, G.G. Scherer, F.N.
    Büchi, Electrochimica Acta 54 (2008) 551–559.
date_created: 2020-01-15T12:21:36Z
date_published: 2008-12-30T00:00:00Z
date_updated: 2021-01-12T08:13:02Z
day: '30'
doi: 10.1016/j.electacta.2008.07.034
extern: '1'
intvolume: '        54'
issue: '2'
language:
- iso: eng
month: '12'
oa_version: None
page: 551-559
publication: Electrochimica Acta
publication_identifier:
  issn:
  - 0013-4686
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Anisotropic, effective diffusivity of porous gas diffusion layer materials
  for PEFC
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2008'
...
---
_id: '7321'
abstract:
- lang: eng
  text: Cell interaction phenomena in polymer electrolyte fuel cell stacks that arise
    from imbalance between adjacent cells are investigated in detail experimentally
    and theoretically. A specialized two-cell stack with advanced localized diagnostics
    was developed and used to analyze the mechanism and effect of cell-to-cell coupling
    as a result of operationally relevant variations in reactant feed flow. Contributions
    to overall and local voltage changes with respect to uniformly operated cells
    are scrutinized. Unequal operation of the cells causes in-plane current in the
    bipolar plate to redistribute current and result in inhomogeneous polarization.
    Both increasing and decreasing polarization along the air-flow path reduces cell
    power as compared to isopotential operation. A two-dimensional model based on
    a commercial computational fluid dynamics code is used to back and extend the
    experimental results to more general cases. Furthermore, the experimental setup
    presented allowed for the first time to perform simultaneous localized electrochemical
    impedance spectroscopy beyond the single-cell level. The mechanism of mutual cell
    interaction on local and integral spectra is revealed. Results show that virtually
    identical operation of the cells is essential to obtain meaningful integral spectra.
article_number: B704
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Ingo A.
  full_name: Schneider, Ingo A.
  last_name: Schneider
- first_name: Pang-Chieh
  full_name: Sui, Pang-Chieh
  last_name: Sui
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Nedjib
  full_name: Djilali, Nedjib
  last_name: Djilali
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Freunberger SA, Schneider IA, Sui P-C, Wokaun A, Djilali N, Büchi FN. Cell
    interaction phenomena in polymer electrolyte fuel cell stacks. <i>Journal of The
    Electrochemical Society</i>. 2008;155(7). doi:<a href="https://doi.org/10.1149/1.2913095">10.1149/1.2913095</a>
  apa: Freunberger, S. A., Schneider, I. A., Sui, P.-C., Wokaun, A., Djilali, N.,
    &#38; Büchi, F. N. (2008). Cell interaction phenomena in polymer electrolyte
    fuel cell stacks. <i>Journal of The Electrochemical Society</i>. The Electrochemical
    Society. <a href="https://doi.org/10.1149/1.2913095">https://doi.org/10.1149/1.2913095</a>
  chicago: Freunberger, Stefan Alexander, Ingo A. Schneider, Pang-Chieh Sui, Alexander
    Wokaun, Nedjib Djilali, and Felix N. Büchi. “Cell Interaction Phenomena in Polymer
    Electrolyte Fuel Cell Stacks.” <i>Journal of The Electrochemical Society</i>.
    The Electrochemical Society, 2008. <a href="https://doi.org/10.1149/1.2913095">https://doi.org/10.1149/1.2913095</a>.
  ieee: S. A. Freunberger, I. A. Schneider, P.-C. Sui, A. Wokaun, N. Djilali, and
    F. N. Büchi, “Cell interaction phenomena in polymer electrolyte fuel cell stacks,”
    <i>Journal of The Electrochemical Society</i>, vol. 155, no. 7. The Electrochemical
    Society, 2008.
  ista: Freunberger SA, Schneider IA, Sui P-C, Wokaun A, Djilali N, Büchi FN. 2008.
    Cell interaction phenomena in polymer electrolyte fuel cell stacks. Journal of
    The Electrochemical Society. 155(7), B704.
  mla: Freunberger, Stefan Alexander, et al. “Cell Interaction Phenomena in Polymer
    Electrolyte Fuel Cell Stacks.” <i>Journal of The Electrochemical Society</i>,
    vol. 155, no. 7, B704, The Electrochemical Society, 2008, doi:<a href="https://doi.org/10.1149/1.2913095">10.1149/1.2913095</a>.
  short: S.A. Freunberger, I.A. Schneider, P.-C. Sui, A. Wokaun, N. Djilali, F.N.
    Büchi, Journal of The Electrochemical Society 155 (2008).
date_created: 2020-01-15T12:21:47Z
date_published: 2008-05-08T00:00:00Z
date_updated: 2021-01-12T08:13:03Z
day: '08'
doi: 10.1149/1.2913095
extern: '1'
intvolume: '       155'
issue: '7'
language:
- iso: eng
month: '05'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
  issn:
  - 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: Cell interaction phenomena in polymer electrolyte fuel cell stacks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 155
year: '2008'
...
