---
_id: '4192'
abstract:
- lang: eng
  text: "During vertebrate gastrulation, the body axis is established by a variety
    of co-ordinated and directed movements of cells. One of these movements is convergence
    and extension (CE), which is regulated by a non-canonical Wnt/planar cell polarity
    (PCP) pathway. From our forward genetic screen, we have identified 3-hydroxy-3-methyglutaryl-coenzyme
    A reductase 1b (hmgcr1b) gene as a dominant enhancer of the silberblick (slb)/wnt11
    CE phenotype. hmgcr1b mutant embryos exhibit only very mild CE phenotype during
    gastrulation while showing a thicker yolk extension at pharyngula stages. Notably,
    abrogation of hmgcr1b also enhances the CE defects of other core PCP mutants/morphants.
    The prenylation pathway is one of branches downstream of HMGCR, and has been implicated
    for lipid modification at the C-terminus of proteins. To test the possibility
    that the prenylation pathway regulates activities of the PCP pathway, we abrogated
    farnesyl transferase (FT) or geranylgeranyl transferase (GGT) function using morpholinos
    on PCP mutant/morphant backgrounds. Consistent with the notion that FT preferentially
    performs lipid modification on to proteins with the CAAX motif including the core
    PCP protein Prickle (Pk), abrogation of FT, but not GGT, enhances the pk1a or
    pk1b morphant CE phenotype, suggesting the specif icity for targets of the prenylation
    enzymes.\r\n"
article_processing_charge: No
author:
- first_name: Masatake
  full_name: Kai, Masatake
  last_name: Kai
- first_name: Nina
  full_name: Buchan, Nina
  last_name: Buchan
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
citation:
  ama: Kai M, Buchan N, Heisenberg C-PJ, Tada M. Regulation of planar cell polarity
    signalling by the prenylation pathway. <i>Mechanisms of Development</i>. 2009;126(Supplement
    1):S132-S132. doi:<a href="https://doi.org/10.1016/j.mod.2009.06.269">10.1016/j.mod.2009.06.269</a>
  apa: Kai, M., Buchan, N., Heisenberg, C.-P. J., &#38; Tada, M. (2009). Regulation
    of planar cell polarity signalling by the prenylation pathway. <i>Mechanisms of
    Development</i>. Elsevier. <a href="https://doi.org/10.1016/j.mod.2009.06.269">https://doi.org/10.1016/j.mod.2009.06.269</a>
  chicago: Kai, Masatake, Nina Buchan, Carl-Philipp J Heisenberg, and Masazumi Tada.
    “Regulation of Planar Cell Polarity Signalling by the Prenylation Pathway.” <i>Mechanisms
    of Development</i>. Elsevier, 2009. <a href="https://doi.org/10.1016/j.mod.2009.06.269">https://doi.org/10.1016/j.mod.2009.06.269</a>.
  ieee: M. Kai, N. Buchan, C.-P. J. Heisenberg, and M. Tada, “Regulation of planar
    cell polarity signalling by the prenylation pathway,” <i>Mechanisms of Development</i>,
    vol. 126, no. Supplement 1. Elsevier, pp. S132–S132, 2009.
  ista: Kai M, Buchan N, Heisenberg C-PJ, Tada M. 2009. Regulation of planar cell
    polarity signalling by the prenylation pathway. Mechanisms of Development. 126(Supplement
    1), S132–S132.
  mla: Kai, Masatake, et al. “Regulation of Planar Cell Polarity Signalling by the
    Prenylation Pathway.” <i>Mechanisms of Development</i>, vol. 126, no. Supplement
    1, Elsevier, 2009, pp. S132–S132, doi:<a href="https://doi.org/10.1016/j.mod.2009.06.269">10.1016/j.mod.2009.06.269</a>.
  short: M. Kai, N. Buchan, C.-P.J. Heisenberg, M. Tada, Mechanisms of Development
    126 (2009) S132–S132.
date_created: 2018-12-11T12:07:30Z
date_published: 2009-08-05T00:00:00Z
date_updated: 2021-01-12T07:55:11Z
day: '05'
doi: 10.1016/j.mod.2009.06.269
extern: '1'
intvolume: '       126'
issue: Supplement 1
language:
- iso: eng
month: '08'
oa_version: None
page: S132 - S132
publication: Mechanisms of Development
publication_status: published
publisher: Elsevier
publist_id: '1927'
status: public
title: Regulation of planar cell polarity signalling by the prenylation pathway
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 126
year: '2009'
...
---
_id: '4206'
abstract:
- lang: eng
  text: Dorsal closure (DC), the closure of a hole in the dorsal epidermis of Drosophila
    embryos by the joining of opposing epithelial cell sheets, has been used as a
    model process to study the molecular and cellular mechanisms underlying epithelial
    spreading and wound healing. Recent studies have provided novel insights into
    how different tissues function cooperatively in this process. Specifically, they
    demonstrate a critical function of the epidermis surrounding the hole in modulating
    the behavior of the amnioserosa cells inside. These findings shed light not only
    on the mechanisms by which the behavior of different tissues is coordinated during
    DC, but also on the general mechanisms by which tissues interact to trigger global
    morphogenesis, an essential but yet poorly explored aspect of embryogenesis.
article_processing_charge: No
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Heisenberg C-PJ. Dorsal closure in Drosophila: cells cannot get out of the
    tight spot. <i>Bioessays : News and Reviews in Molecular, Cellular and Developmental
    Biology</i>. 2009;31(12):1284-1287. doi:<a href="https://doi.org/10.1002/bies.200900109">10.1002/bies.200900109</a>'
  apa: 'Heisenberg, C.-P. J. (2009). Dorsal closure in Drosophila: cells cannot get
    out of the tight spot. <i>Bioessays : News and Reviews in Molecular, Cellular
    and Developmental Biology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/bies.200900109">https://doi.org/10.1002/bies.200900109</a>'
  chicago: 'Heisenberg, Carl-Philipp J. “Dorsal Closure in Drosophila: Cells Cannot
    Get out of the Tight Spot.” <i>Bioessays : News and Reviews in Molecular, Cellular
    and Developmental Biology</i>. Wiley-Blackwell, 2009. <a href="https://doi.org/10.1002/bies.200900109">https://doi.org/10.1002/bies.200900109</a>.'
  ieee: 'C.-P. J. Heisenberg, “Dorsal closure in Drosophila: cells cannot get out
    of the tight spot,” <i>Bioessays : News and Reviews in Molecular, Cellular and
    Developmental Biology</i>, vol. 31, no. 12. Wiley-Blackwell, pp. 1284–1287, 2009.'
  ista: 'Heisenberg C-PJ. 2009. Dorsal closure in Drosophila: cells cannot get out
    of the tight spot. Bioessays : News and Reviews in Molecular, Cellular and Developmental
    Biology. 31(12), 1284–1287.'
  mla: 'Heisenberg, Carl-Philipp J. “Dorsal Closure in Drosophila: Cells Cannot Get
    out of the Tight Spot.” <i>Bioessays : News and Reviews in Molecular, Cellular
    and Developmental Biology</i>, vol. 31, no. 12, Wiley-Blackwell, 2009, pp. 1284–87,
    doi:<a href="https://doi.org/10.1002/bies.200900109">10.1002/bies.200900109</a>.'
  short: 'C.-P.J. Heisenberg, Bioessays : News and Reviews in Molecular, Cellular
    and Developmental Biology 31 (2009) 1284–1287.'
date_created: 2018-12-11T12:07:35Z
date_published: 2009-12-01T00:00:00Z
date_updated: 2021-01-12T07:55:17Z
day: '01'
doi: 10.1002/bies.200900109
extern: '1'
intvolume: '        31'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1284 - 1287
publication: 'Bioessays : News and Reviews in Molecular, Cellular and Developmental
  Biology'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1911'
status: public
title: 'Dorsal closure in Drosophila: cells cannot get out of the tight spot'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2009'
...
---
_id: '4217'
abstract:
- lang: eng
  text: Nuclear movements play an essential role in metazoan development. Although
    the intracellular transport mechanisms underlying nuclear movements have been
    studied in detail, relatively little is known about signals from surrounding cells
    and tissues controlling these movements. Here, we show that, in gastrulating zebrafish
    embryos, convergence movements of nuclei within the yolk syncytial layer (YSL)
    are guided by mesoderm and endoderm progenitors migrating along the surface of
    the yolk towards the dorsal side of the developing gastrula. Progenitor cells
    direct the convergence movements of internal yolk syncytial nuclei (iYSN) by modulating
    cortical flow within the YSL in which the iYSN are entrained. The effect of mesoderm
    and endoderm progenitors on the convergence movement of iYSN depends on the expression
    of E-cadherin, indicating that adhesive contact between the cells and the YSL
    is required for the mesendoderm-modulated YSL cortical flow mediating nuclear
    convergence. In summary, our data reveal a crucial function for cortical flow
    in the coordination of syncytial nuclear movements with surrounding cells and
    tissues during zebrafish gastrulation.
article_processing_charge: No
author:
- first_name: Lara
  full_name: Carvalho, Lara
  last_name: Carvalho
- first_name: Jan
  full_name: Stuehmer, Jan
  last_name: Stuehmer
- first_name: Justin
  full_name: Bois, Justin
  last_name: Bois
- first_name: Yannis
  full_name: Kalaidzidis, Yannis
  last_name: Kalaidzidis
- first_name: Virginie
  full_name: Lecaudey, Virginie
  last_name: Lecaudey
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Carvalho L, Stuehmer J, Bois J, Kalaidzidis Y, Lecaudey V, Heisenberg C-PJ.
    Control of convergent yolk syncytial layer nuclear movement in zebrafish. <i>Development</i>.
    2009;136(8):1305-1315. doi:<a href="https://doi.org/10.1242/dev.026922">10.1242/dev.026922</a>
  apa: Carvalho, L., Stuehmer, J., Bois, J., Kalaidzidis, Y., Lecaudey, V., &#38;
    Heisenberg, C.-P. J. (2009). Control of convergent yolk syncytial layer nuclear
    movement in zebrafish. <i>Development</i>. Company of Biologists. <a href="https://doi.org/10.1242/dev.026922">https://doi.org/10.1242/dev.026922</a>
  chicago: Carvalho, Lara, Jan Stuehmer, Justin Bois, Yannis Kalaidzidis, Virginie
    Lecaudey, and Carl-Philipp J Heisenberg. “Control of Convergent Yolk Syncytial
    Layer Nuclear Movement in Zebrafish.” <i>Development</i>. Company of Biologists,
    2009. <a href="https://doi.org/10.1242/dev.026922">https://doi.org/10.1242/dev.026922</a>.
  ieee: L. Carvalho, J. Stuehmer, J. Bois, Y. Kalaidzidis, V. Lecaudey, and C.-P.
    J. Heisenberg, “Control of convergent yolk syncytial layer nuclear movement in
    zebrafish,” <i>Development</i>, vol. 136, no. 8. Company of Biologists, pp. 1305–1315,
    2009.
  ista: Carvalho L, Stuehmer J, Bois J, Kalaidzidis Y, Lecaudey V, Heisenberg C-PJ.
    2009. Control of convergent yolk syncytial layer nuclear movement in zebrafish.
    Development. 136(8), 1305–1315.
  mla: Carvalho, Lara, et al. “Control of Convergent Yolk Syncytial Layer Nuclear
    Movement in Zebrafish.” <i>Development</i>, vol. 136, no. 8, Company of Biologists,
    2009, pp. 1305–15, doi:<a href="https://doi.org/10.1242/dev.026922">10.1242/dev.026922</a>.
  short: L. Carvalho, J. Stuehmer, J. Bois, Y. Kalaidzidis, V. Lecaudey, C.-P.J. Heisenberg,
    Development 136 (2009) 1305–1315.
date_created: 2018-12-11T12:07:39Z
date_published: 2009-04-15T00:00:00Z
date_updated: 2021-01-12T07:55:22Z
day: '15'
doi: 10.1242/dev.026922
extern: '1'
intvolume: '       136'
issue: '8'
language:
- iso: eng
month: '04'
oa_version: None
page: 1305 - 1315
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '1901'
status: public
title: Control of convergent yolk syncytial layer nuclear movement in zebrafish
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2009'
...
---
_id: '4223'
abstract:
- lang: eng
  text: 'Both Gram-positive and Gram-negative bacteria contain bactoprenol-dependent
    biosynthetic pathways expressing non-essential cell surface polysaccharides that
    function as virulence factors. Although these polymers are not required for bacterial
    viability in vitro, genes in many of the biosynthetic pathways are conditionally
    essential: they cannot be deleted except in strains incapable of initiating polymer
    synthesis. We report a cell-based, pathway-specific strategy to screen for small
    molecule inhibitors of conditionally essential enzymes. The screen identifies
    molecules that prevent the growth of a wildtype bacterial strain but do not affect
    the growth of a mutant strain incapable of initiating polymer synthesis. We have
    applied this approach to discover inhibitors of wall teichoic acid (WTA) biosynthesis
    in Staphylococcus aureus. WTAs are anionic cell surface polysaccharides required
    for host colonization that have been suggested as targets for new antimicrobials.
    We have identified a small molecule, 7-chloro-N,N-diethyl-3-(phenylsulfonyl)-[1,2,3]triazolo[1,5-a]quinolin-5-amine
    (1835F03), that inhibits the growth of a panel of S. aureus strains (MIC = 1−3
    μg mL−1), including clinical methicillin-resistant S. aureus (MRSA) isolates.
    Using a combination of biochemistry and genetics, we have identified the molecular
    target as TarG, the transmembrane component of the ABC transporter that exports
    WTAs to the cell surface. We also show that preventing the completion of WTA biosynthesis
    once it has been initiated triggers growth arrest. The discovery of 1835F03 validates
    our chemical genetics strategy for identifying inhibitors of conditionally essential
    enzymes, and the strategy should be applicable to many other bactoprenol-dependent
    biosynthetic pathways in the pursuit of novel antibacterials and probes of bacterial
    stress responses.'
article_processing_charge: No
author:
- first_name: Jonathan
  full_name: Swoboda, Jonathan
  last_name: Swoboda
- first_name: Timothy
  full_name: Meredith, Timothy
  last_name: Meredith
- first_name: Jennifer
  full_name: Campbell, Jennifer
  last_name: Campbell
- first_name: Stephanie
  full_name: Brown, Stephanie
  last_name: Brown
- first_name: Takashi
  full_name: Suzuki, Takashi
  last_name: Suzuki
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Amy
  full_name: Malhowski, Amy
  last_name: Malhowski
- first_name: Roy
  full_name: Kishony, Roy
  last_name: Kishony
- first_name: Michael
  full_name: Gilmore, Michael
  last_name: Gilmore
- first_name: Suzanne
  full_name: Walker, Suzanne
  last_name: Walker
citation:
  ama: Swoboda J, Meredith T, Campbell J, et al. Discovery of a Small Molecule that
    Blocks Wall Teichoic Acid Biosynthesis in Staphylococcus aureus. <i>ACS Chemical
    Biology</i>. 2009;4(10):875-883. doi:<a href="https://doi.org/10.1021/cb900151k">10.1021/cb900151k</a>
  apa: Swoboda, J., Meredith, T., Campbell, J., Brown, S., Suzuki, T., Bollenbach,
    M. T., … Walker, S. (2009). Discovery of a Small Molecule that Blocks Wall Teichoic
    Acid Biosynthesis in Staphylococcus aureus. <i>ACS Chemical Biology</i>. American
    Chemical Society. <a href="https://doi.org/10.1021/cb900151k">https://doi.org/10.1021/cb900151k</a>
  chicago: Swoboda, Jonathan, Timothy Meredith, Jennifer Campbell, Stephanie Brown,
    Takashi Suzuki, Mark Tobias Bollenbach, Amy Malhowski, Roy Kishony, Michael Gilmore,
    and Suzanne Walker. “Discovery of a Small Molecule That Blocks Wall Teichoic Acid
    Biosynthesis in Staphylococcus Aureus.” <i>ACS Chemical Biology</i>. American
    Chemical Society, 2009. <a href="https://doi.org/10.1021/cb900151k">https://doi.org/10.1021/cb900151k</a>.
  ieee: J. Swoboda <i>et al.</i>, “Discovery of a Small Molecule that Blocks Wall
    Teichoic Acid Biosynthesis in Staphylococcus aureus,” <i>ACS Chemical Biology</i>,
    vol. 4, no. 10. American Chemical Society, pp. 875–883, 2009.
  ista: Swoboda J, Meredith T, Campbell J, Brown S, Suzuki T, Bollenbach MT, Malhowski
    A, Kishony R, Gilmore M, Walker S. 2009. Discovery of a Small Molecule that Blocks
    Wall Teichoic Acid Biosynthesis in Staphylococcus aureus. ACS Chemical Biology.
    4(10), 875–883.
  mla: Swoboda, Jonathan, et al. “Discovery of a Small Molecule That Blocks Wall Teichoic
    Acid Biosynthesis in Staphylococcus Aureus.” <i>ACS Chemical Biology</i>, vol.
    4, no. 10, American Chemical Society, 2009, pp. 875–83, doi:<a href="https://doi.org/10.1021/cb900151k">10.1021/cb900151k</a>.
  short: J. Swoboda, T. Meredith, J. Campbell, S. Brown, T. Suzuki, M.T. Bollenbach,
    A. Malhowski, R. Kishony, M. Gilmore, S. Walker, ACS Chemical Biology 4 (2009)
    875–883.
date_created: 2018-12-11T12:07:41Z
date_published: 2009-08-18T00:00:00Z
date_updated: 2021-01-12T07:55:25Z
day: '18'
doi: 10.1021/cb900151k
extern: '1'
intvolume: '         4'
issue: '10'
language:
- iso: eng
main_file_link:
- url: 10.1021/cb900151k [doi]
month: '08'
oa_version: None
page: 875 - 883
publication: ACS Chemical Biology
publication_status: published
publisher: American Chemical Society
publist_id: '1894'
status: public
title: Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis in
  Staphylococcus aureus
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2009'
...
---
_id: '4228'
abstract:
- lang: eng
  text: Suppressive drug interactions, in which one antibiotic can actually help bacterial
    cells to grow faster in the presence of another, occur between protein and DNA
    synthesis inhibitors. Here, we show that this suppression results from nonoptimal
    regulation of ribosomal genes in the presence of DNA stress. Using GFP-tagged
    transcription reporters in Escherichia coli, we find that ribosomal genes are
    not directly regulated by DNA stress, leading to an imbalance between cellular
    DNA and protein content. To test whether ribosomal gene expression under DNA stress
    is nonoptimal for growth rate, we sequentially deleted up to six of the seven
    ribosomal RNA operons. These synthetic manipulations of ribosomal gene expression
    correct the protein-DNA imbalance, lead to improved survival and growth, and completely
    remove the suppressive drug interaction. A simple mathematical model explains
    the nonoptimal regulation in different nutrient environments. These results reveal
    the genetic mechanism underlying an important class of suppressive drug interactions.
author:
- first_name: Tobias
  full_name: Bollenbach, Tobias
  last_name: Bollenbach
- first_name: Selwyn
  full_name: Quan, Selwyn
  last_name: Quan
- first_name: Remy P
  full_name: Remy Chait
  id: 3464AE84-F248-11E8-B48F-1D18A9856A87
  last_name: Chait
  orcid: 0000-0003-0876-3187
- first_name: Roy
  full_name: Kishony, Roy
  last_name: Kishony
citation:
  ama: Bollenbach T, Quan S, Chait RP, Kishony R. Nonoptimal Microbial Response to
    Antibiotics Underlies Suppressive Drug Interactions. <i>Cell</i>. 2009;139(4):707-718.
    doi:<a href="https://doi.org/10.1016/j.cell.2009.10.025">10.1016/j.cell.2009.10.025</a>
  apa: Bollenbach, T., Quan, S., Chait, R. P., &#38; Kishony, R. (2009). Nonoptimal
    Microbial Response to Antibiotics Underlies Suppressive Drug Interactions. <i>Cell</i>.
    Cell Press. <a href="https://doi.org/10.1016/j.cell.2009.10.025">https://doi.org/10.1016/j.cell.2009.10.025</a>
  chicago: Bollenbach, Tobias, Selwyn Quan, Remy P Chait, and Roy Kishony. “Nonoptimal
    Microbial Response to Antibiotics Underlies Suppressive Drug Interactions.” <i>Cell</i>.
    Cell Press, 2009. <a href="https://doi.org/10.1016/j.cell.2009.10.025">https://doi.org/10.1016/j.cell.2009.10.025</a>.
  ieee: T. Bollenbach, S. Quan, R. P. Chait, and R. Kishony, “Nonoptimal Microbial
    Response to Antibiotics Underlies Suppressive Drug Interactions,” <i>Cell</i>,
    vol. 139, no. 4. Cell Press, pp. 707–718, 2009.
  ista: Bollenbach T, Quan S, Chait RP, Kishony R. 2009. Nonoptimal Microbial Response
    to Antibiotics Underlies Suppressive Drug Interactions. Cell. 139(4), 707–718.
  mla: Bollenbach, Tobias, et al. “Nonoptimal Microbial Response to Antibiotics Underlies
    Suppressive Drug Interactions.” <i>Cell</i>, vol. 139, no. 4, Cell Press, 2009,
    pp. 707–18, doi:<a href="https://doi.org/10.1016/j.cell.2009.10.025">10.1016/j.cell.2009.10.025</a>.
  short: T. Bollenbach, S. Quan, R.P. Chait, R. Kishony, Cell 139 (2009) 707–718.
date_created: 2018-12-11T12:07:43Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:55:27Z
day: '01'
doi: 10.1016/j.cell.2009.10.025
extern: 1
intvolume: '       139'
issue: '4'
month: '01'
page: 707 - 718
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '1890'
quality_controlled: 0
status: public
title: Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions
type: journal_article
volume: 139
year: '2009'
...
---
_id: '4231'
abstract:
- lang: eng
  text: The evolution of quantitative characters depends on the frequencies of the
    alleles involved, yet these frequencies cannot usually be measured. Previous groups
    have proposed an approximation to the dynamics of quantitative traits, based on
    an analogy with statistical mechanics. We present a modified version of that approach,
    which makes the analogy more precise and applies quite generally to describe the
    evolution of allele frequencies. We calculate explicitly how the macroscopic quantities
    (i.e., quantities that depend on the quantitative trait) depend on evolutionary
    forces, in a way that is independent of the microscopic details. We first show
    that the stationary distribution of allele frequencies under drift, selection,
    and mutation maximizes a certain measure of entropy, subject to constraints on
    the expectation of observable quantities. We then approximate the dynamical changes
    in these expectations, assuming that the distribution of allele frequencies always
    maximizes entropy, conditional on the expected values. When applied to directional
    selection on an additive trait, this gives a very good approximation to the evolution
    of the trait mean and the genetic variance, when the number of mutations per generation
    is sufficiently high (4Nμ &gt; 1). We show how the method can be modified for
    small mutation rates (4Nμ → 0). We outline how this method describes epistatic
    interactions as, for example, with stabilizing selection.
acknowledgement: "N.B. was supported by the Engineering and Physical Sciences Research
  Council (GR/T11753 and GR/T19537) and by the Royal Society.\r\nWe are grateful to
  Ellen Baake for helping to initiate this project and for her comments on this manuscript.
  We also thank Michael Turelli for his comments on the manuscript and I. Pen for
  discussions and support in this project. This project was a result of a collaboration
  supported by the European Science Foundation grant “Integrating population genetics
  and conservation biology.” "
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Harold
  full_name: De Vladar, Harold
  last_name: De Vladar
citation:
  ama: Barton NH, De Vladar H. Statistical mechanics and the evolution of polygenic
    quantitative traits. <i>Genetics</i>. 2009;181(3):997-1011. doi:<a href="https://doi.org/10.1534/genetics.108.099309">10.1534/genetics.108.099309</a>
  apa: Barton, N. H., &#38; De Vladar, H. (2009). Statistical mechanics and the evolution
    of polygenic quantitative traits. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1534/genetics.108.099309">https://doi.org/10.1534/genetics.108.099309</a>
  chicago: Barton, Nicholas H, and Harold De Vladar. “Statistical Mechanics and the
    Evolution of Polygenic Quantitative Traits.” <i>Genetics</i>. Genetics Society
    of America, 2009. <a href="https://doi.org/10.1534/genetics.108.099309">https://doi.org/10.1534/genetics.108.099309</a>.
  ieee: N. H. Barton and H. De Vladar, “Statistical mechanics and the evolution of
    polygenic quantitative traits,” <i>Genetics</i>, vol. 181, no. 3. Genetics Society
    of America, pp. 997–1011, 2009.
  ista: Barton NH, De Vladar H. 2009. Statistical mechanics and the evolution of polygenic
    quantitative traits. Genetics. 181(3), 997–1011.
  mla: Barton, Nicholas H., and Harold De Vladar. “Statistical Mechanics and the Evolution
    of Polygenic Quantitative Traits.” <i>Genetics</i>, vol. 181, no. 3, Genetics
    Society of America, 2009, pp. 997–1011, doi:<a href="https://doi.org/10.1534/genetics.108.099309">10.1534/genetics.108.099309</a>.
  short: N.H. Barton, H. De Vladar, Genetics 181 (2009) 997–1011.
corr_author: '1'
date_created: 2018-12-11T12:07:44Z
date_published: 2009-03-01T00:00:00Z
date_updated: 2025-09-30T09:52:35Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.108.099309
external_id:
  isi:
  - '000270213500018'
intvolume: '       181'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 997 - 1011
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '1882'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical mechanics and the evolution of polygenic quantitative traits
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 181
year: '2009'
...
---
_id: '4232'
article_processing_charge: No
author:
- first_name: Harold
  full_name: Vladar, Harold
  id: 2A181218-F248-11E8-B48F-1D18A9856A87
  last_name: Vladar
  orcid: 0000-0002-5985-7653
citation:
  ama: de Vladar H. Stochasticity and Variability in the dynamics and genetics of
    populations. 2009.
  apa: de Vladar, H. (2009). <i>Stochasticity and Variability in the dynamics and
    genetics of populations</i>. Faculty of mathematical and natural sciences, University
    of Groningen.
  chicago: Vladar, Harold de. “Stochasticity and Variability in the Dynamics and Genetics
    of Populations.” Faculty of mathematical and natural sciences, University of Groningen,
    2009.
  ieee: H. de Vladar, “Stochasticity and Variability in the dynamics and genetics
    of populations,” Faculty of mathematical and natural sciences, University of Groningen,
    2009.
  ista: de Vladar H. 2009. Stochasticity and Variability in the dynamics and genetics
    of populations. Faculty of mathematical and natural sciences, University of Groningen.
  mla: de Vladar, Harold. <i>Stochasticity and Variability in the Dynamics and Genetics
    of Populations</i>. Faculty of mathematical and natural sciences, University of
    Groningen, 2009.
  short: H. de Vladar, Stochasticity and Variability in the Dynamics and Genetics
    of Populations, Faculty of mathematical and natural sciences, University of Groningen,
    2009.
date_created: 2018-12-11T12:07:44Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2025-07-02T06:46:07Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication_status: published
publisher: Faculty of mathematical and natural sciences, University of Groningen
publist_id: '1883'
status: public
title: Stochasticity and Variability in the dynamics and genetics of populations
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '4242'
abstract:
- lang: eng
  text: 'Felsenstein distinguished two ways by which selection can directly strengthen
    isolation. First, a modifier that strengthens prezygotic isolation can be favored
    everywhere. This fits with the traditional view of reinforcement as an adaptation
    to reduce deleterious hybridization by strengthening assortative mating. Second,
    selection can favor association between different incompatibilities, despite recombination.
    We generalize this “two allele” model to follow associations among any number
    of incompatibilities, which may include both assortment and hybrid inviability.
    Our key argument is that this process, of coupling between incompatibilities,
    may be quite different from the usual view of reinforcement: strong isolation
    can evolve through the coupling of any kind of incompatibility, whether prezygotic
    or postzygotic. Single locus incompatibilities become coupled because associations
    between them increase the variance in compatibility, which in turn increases mean
    fitness if there is positive epistasis. Multiple incompatibilities, each maintained
    by epistasis, can become coupled in the same way. In contrast, a single-locus
    incompatibility can become coupled with loci that reduce the viability of haploid
    hybrids because this reduces harmful recombination. We obtain simple approximations
    for the limits of tight linkage, and strong assortment, and show how assortment
    alleles can invade through associations with other components of reproductive
    isolation.'
acknowledgement: "This work was supported by a Royal Society/Wolfson Research Merit
  award, and by a grant from the Natural Environment Research Council.\r\nWe are very
  grateful for insightful comments from S. P. Otto, and for helpful suggestions from
  the referees and the Associate Editor, Maria Servedio."
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Maria
  full_name: De Cara, Maria
  last_name: De Cara
citation:
  ama: Barton NH, De Cara M. The evolution of strong reproductive isolation. <i>Evolution;
    International Journal of Organic Evolution</i>. 2009;63(5):1171-1190. doi:<a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">10.1111/j.1558-5646.2009.00622.x</a>
  apa: Barton, N. H., &#38; De Cara, M. (2009). The evolution of strong reproductive
    isolation. <i>Evolution; International Journal of Organic Evolution</i>. Wiley.
    <a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">https://doi.org/10.1111/j.1558-5646.2009.00622.x</a>
  chicago: Barton, Nicholas H, and Maria De Cara. “The Evolution of Strong Reproductive
    Isolation.” <i>Evolution; International Journal of Organic Evolution</i>. Wiley,
    2009. <a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">https://doi.org/10.1111/j.1558-5646.2009.00622.x</a>.
  ieee: N. H. Barton and M. De Cara, “The evolution of strong reproductive isolation,”
    <i>Evolution; International Journal of Organic Evolution</i>, vol. 63, no. 5.
    Wiley, pp. 1171–1190, 2009.
  ista: Barton NH, De Cara M. 2009. The evolution of strong reproductive isolation.
    Evolution; International Journal of Organic Evolution. 63(5), 1171–1190.
  mla: Barton, Nicholas H., and Maria De Cara. “The Evolution of Strong Reproductive
    Isolation.” <i>Evolution; International Journal of Organic Evolution</i>, vol.
    63, no. 5, Wiley, 2009, pp. 1171–90, doi:<a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">10.1111/j.1558-5646.2009.00622.x</a>.
  short: N.H. Barton, M. De Cara, Evolution; International Journal of Organic Evolution
    63 (2009) 1171–1190.
corr_author: '1'
date_created: 2018-12-11T12:07:48Z
date_published: 2009-05-01T00:00:00Z
date_updated: 2025-09-30T09:52:11Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/j.1558-5646.2009.00622.x
external_id:
  isi:
  - '000265145800006'
file:
- access_level: open_access
  checksum: 1920d2e25ef335833764256c1a47bbfb
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:46Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '4903'
  file_name: IST-2016-551-v1+1_BartonDeCaraRevNew.pdf
  file_size: 720913
  relation: main_file
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  file_id: '4904'
  file_name: IST-2016-551-v1+2_BartonDeCaraRevNewSI.pdf
  file_size: 290160
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file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '        63'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 1171 - 1190
publication: Evolution; International Journal of Organic Evolution
publication_status: published
publisher: Wiley
publist_id: '1866'
pubrep_id: '551'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolution of strong reproductive isolation
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 63
year: '2009'
...
---
_id: '1766'
abstract:
- lang: eng
  text: We demonstrate the time-resolved driving of two-photon blue sideband transitions
    between superconducting qubits and a transmission line resonator. As an example
    of using these sideband transitions for a two-qubit operation, we implement a
    pulse sequence that first entangles one qubit with the resonator and subsequently
    distributes the entanglement between two qubits. We show the generation of 75%
    fidelity Bell states by this method. The full density matrix of the two-qubit
    system is extracted using joint measurement and quantum state tomography and shows
    close agreement with numerical simulation.
acknowledgement: This work was supported by ETH Zurich, the Swiss National Science
  Foundation, and by the EC via the EuroSQIP project and the Marie-Curie program (P.
  J. L.)
author:
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: Patrick
  full_name: Maurer, Patrick
  last_name: Maurer
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Leek P, Filipp S, Maurer P, et al. Using sideband transitions for two-qubit
    operations in superconducting circuits. <i>Physical Review B - Condensed Matter
    and Materials Physics</i>. 2009;79(18). doi:<a href="https://doi.org/10.1103/PhysRevB.79.180511">10.1103/PhysRevB.79.180511</a>
  apa: Leek, P., Filipp, S., Maurer, P., Baur, M., Bianchetti, R., Fink, J. M., …
    Wallraff, A. (2009). Using sideband transitions for two-qubit operations in superconducting
    circuits. <i>Physical Review B - Condensed Matter and Materials Physics</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevB.79.180511">https://doi.org/10.1103/PhysRevB.79.180511</a>
  chicago: Leek, Peter, Stefan Filipp, Patrick Maurer, Matthias Baur, R Bianchetti,
    Johannes M Fink, M Göppl, L. Steffen, and Andreas Wallraff. “Using Sideband Transitions
    for Two-Qubit Operations in Superconducting Circuits.” <i>Physical Review B -
    Condensed Matter and Materials Physics</i>. American Physical Society, 2009. <a
    href="https://doi.org/10.1103/PhysRevB.79.180511">https://doi.org/10.1103/PhysRevB.79.180511</a>.
  ieee: P. Leek <i>et al.</i>, “Using sideband transitions for two-qubit operations
    in superconducting circuits,” <i>Physical Review B - Condensed Matter and Materials
    Physics</i>, vol. 79, no. 18. American Physical Society, 2009.
  ista: Leek P, Filipp S, Maurer P, Baur M, Bianchetti R, Fink JM, Göppl M, Steffen
    L, Wallraff A. 2009. Using sideband transitions for two-qubit operations in superconducting
    circuits. Physical Review B - Condensed Matter and Materials Physics. 79(18).
  mla: Leek, Peter, et al. “Using Sideband Transitions for Two-Qubit Operations in
    Superconducting Circuits.” <i>Physical Review B - Condensed Matter and Materials
    Physics</i>, vol. 79, no. 18, American Physical Society, 2009, doi:<a href="https://doi.org/10.1103/PhysRevB.79.180511">10.1103/PhysRevB.79.180511</a>.
  short: P. Leek, S. Filipp, P. Maurer, M. Baur, R. Bianchetti, J.M. Fink, M. Göppl,
    L. Steffen, A. Wallraff, Physical Review B - Condensed Matter and Materials Physics
    79 (2009).
date_created: 2018-12-11T11:53:54Z
date_published: 2009-05-01T00:00:00Z
date_updated: 2021-01-12T06:53:04Z
day: '01'
doi: 10.1103/PhysRevB.79.180511
extern: 1
intvolume: '        79'
issue: '18'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0812.2678
month: '05'
oa: 1
publication: Physical Review B - Condensed Matter and Materials Physics
publication_status: published
publisher: American Physical Society
publist_id: '5354'
quality_controlled: 0
status: public
title: Using sideband transitions for two-qubit operations in superconducting circuits
type: journal_article
volume: 79
year: '2009'
...
---
_id: '1767'
abstract:
- lang: eng
  text: We present spectroscopic measurements of the Autler-Townes doublet and the
    sidebands of the Mollow triplet in a driven superconducting qubit. The ground
    to first excited state transition of the qubit is strongly pumped while the resulting
    dressed qubit spectrum is probed with a weak tone. The corresponding transitions
    are detected using dispersive readout of the qubit coupled off resonantly to a
    microwave transmission line resonator. The observed frequencies of the Autler-Townes
    and Mollow spectral lines are in good agreement with a dispersive Jaynes-Cummings
    model taking into account higher excited qubit states and dispersive level shifts
    due to off-resonant drives.
acknowledgement: This work was supported by the Swiss National Science Foundation
  and by ETH Zürich. P. J. L. acknowledges support from the EC via an Intra-European
  Marie-Curie Fellowship. A. B. was supported by NSERC, CIFAR, FQRNT, and Alfred P.
  Sloan Foundation
author:
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: Alexandre
  full_name: Blais, Alexandre
  last_name: Blais
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Baur M, Filipp S, Bianchetti R, et al. Measurement of autler-townes and mollow
    transitions in a strongly driven superconducting qubit. <i>Physical Review Letters</i>.
    2009;102(24). doi:<a href="https://doi.org/10.1103/PhysRevLett.102.243602">10.1103/PhysRevLett.102.243602</a>
  apa: Baur, M., Filipp, S., Bianchetti, R., Fink, J. M., Göppl, M., Steffen, L.,
    … Wallraff, A. (2009). Measurement of autler-townes and mollow transitions in
    a strongly driven superconducting qubit. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.102.243602">https://doi.org/10.1103/PhysRevLett.102.243602</a>
  chicago: Baur, Matthias, Stefan Filipp, R Bianchetti, Johannes M Fink, M Göppl,
    L. Steffen, Peter Leek, Alexandre Blais, and Andreas Wallraff. “Measurement of
    Autler-Townes and Mollow Transitions in a Strongly Driven Superconducting Qubit.”
    <i>Physical Review Letters</i>. American Physical Society, 2009. <a href="https://doi.org/10.1103/PhysRevLett.102.243602">https://doi.org/10.1103/PhysRevLett.102.243602</a>.
  ieee: M. Baur <i>et al.</i>, “Measurement of autler-townes and mollow transitions
    in a strongly driven superconducting qubit,” <i>Physical Review Letters</i>, vol.
    102, no. 24. American Physical Society, 2009.
  ista: Baur M, Filipp S, Bianchetti R, Fink JM, Göppl M, Steffen L, Leek P, Blais
    A, Wallraff A. 2009. Measurement of autler-townes and mollow transitions in a
    strongly driven superconducting qubit. Physical Review Letters. 102(24).
  mla: Baur, Matthias, et al. “Measurement of Autler-Townes and Mollow Transitions
    in a Strongly Driven Superconducting Qubit.” <i>Physical Review Letters</i>, vol.
    102, no. 24, American Physical Society, 2009, doi:<a href="https://doi.org/10.1103/PhysRevLett.102.243602">10.1103/PhysRevLett.102.243602</a>.
  short: M. Baur, S. Filipp, R. Bianchetti, J.M. Fink, M. Göppl, L. Steffen, P. Leek,
    A. Blais, A. Wallraff, Physical Review Letters 102 (2009).
date_created: 2018-12-11T11:53:54Z
date_published: 2009-06-19T00:00:00Z
date_updated: 2021-01-12T06:53:04Z
day: '19'
doi: 10.1103/PhysRevLett.102.243602
extern: 1
intvolume: '       102'
issue: '24'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0812.4384
month: '06'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5352'
quality_controlled: 0
status: public
title: Measurement of autler-townes and mollow transitions in a strongly driven superconducting
  qubit
type: journal_article
volume: 102
year: '2009'
...
---
_id: '1768'
abstract:
- lang: eng
  text: Quantum state tomography is an important tool in quantum information science
    for complete characterization of multiqubit states and their correlations. Here
    we report a method to perform a joint simultaneous readout of two superconducting
    qubits dispersively coupled to the same mode of a microwave transmission line
    resonator. The nonlinear dependence of the resonator transmission on the qubit
    state dependent cavity frequency allows us to extract the full two-qubit correlations
    without the need for single-shot readout of individual qubits. We employ standard
    tomographic techniques to reconstruct the density matrix of two-qubit quantum
    states.
acknowledgement: This work was supported by Swiss National Science Foundation (SNF)
  and ETH Zurich. P. J. L. was supported by the EC with a MC-EIF, J. M. G. by CIFAR,
  MRI, MITACS, and NSERC, and A. B. by NSERC and CIFAR
author:
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: Patrick
  full_name: Maurer, Patrick
  last_name: Maurer
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Jay
  full_name: Gambetta, Jay M
  last_name: Gambetta
- first_name: Alexandre
  full_name: Blais, Alexandre
  last_name: Blais
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Filipp S, Maurer P, Leek P, et al. Two-qubit state tomography using a joint
    dispersive readout. <i>Physical Review Letters</i>. 2009;102(20). doi:<a href="https://doi.org/10.1103/PhysRevLett.102.200402">10.1103/PhysRevLett.102.200402</a>
  apa: Filipp, S., Maurer, P., Leek, P., Baur, M., Bianchetti, R., Fink, J. M., …
    Wallraff, A. (2009). Two-qubit state tomography using a joint dispersive readout.
    <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.102.200402">https://doi.org/10.1103/PhysRevLett.102.200402</a>
  chicago: Filipp, Stefan, Patrick Maurer, Peter Leek, Matthias Baur, R Bianchetti,
    Johannes M Fink, M Göppl, et al. “Two-Qubit State Tomography Using a Joint Dispersive
    Readout.” <i>Physical Review Letters</i>. American Physical Society, 2009. <a
    href="https://doi.org/10.1103/PhysRevLett.102.200402">https://doi.org/10.1103/PhysRevLett.102.200402</a>.
  ieee: S. Filipp <i>et al.</i>, “Two-qubit state tomography using a joint dispersive
    readout,” <i>Physical Review Letters</i>, vol. 102, no. 20. American Physical
    Society, 2009.
  ista: Filipp S, Maurer P, Leek P, Baur M, Bianchetti R, Fink JM, Göppl M, Steffen
    L, Gambetta J, Blais A, Wallraff A. 2009. Two-qubit state tomography using a joint
    dispersive readout. Physical Review Letters. 102(20).
  mla: Filipp, Stefan, et al. “Two-Qubit State Tomography Using a Joint Dispersive
    Readout.” <i>Physical Review Letters</i>, vol. 102, no. 20, American Physical
    Society, 2009, doi:<a href="https://doi.org/10.1103/PhysRevLett.102.200402">10.1103/PhysRevLett.102.200402</a>.
  short: S. Filipp, P. Maurer, P. Leek, M. Baur, R. Bianchetti, J.M. Fink, M. Göppl,
    L. Steffen, J. Gambetta, A. Blais, A. Wallraff, Physical Review Letters 102 (2009).
date_created: 2018-12-11T11:53:54Z
date_published: 2009-05-18T00:00:00Z
date_updated: 2021-01-12T06:53:04Z
day: '18'
doi: 10.1103/PhysRevLett.102.200402
extern: 1
intvolume: '       102'
issue: '20'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0812.2485
month: '05'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5353'
quality_controlled: 0
status: public
title: Two-qubit state tomography using a joint dispersive readout
type: journal_article
volume: 102
year: '2009'
...
---
_id: '1769'
abstract:
- lang: eng
  text: We present an ideal realization of the Tavis-Cummings model in the absence
    of atom number and coupling fluctuations by embedding a discrete number of fully
    controllable superconducting qubits at fixed positions into a transmission line
    resonator. Measuring the vacuum Rabi mode splitting with one, two, and three qubits
    strongly coupled to the cavity field, we explore both bright and dark dressed
    collective multiqubit states and observe the discrete N scaling of the collective
    dipole coupling strength. Our experiments demonstrate a novel approach to explore
    collective states, such as the W state, in a fully globally and locally controllable
    quantum system. Our scalable approach is interesting for solid-state quantum information
    processing and for fundamental multiatom quantum optics experiments with fixed
    atom numbers.
acknowledgement: This work was supported by SNF Grant No. 200021-111899 and ETHZ.
  P. J. L. was supported by the EU with a MC-EIF. A. B. was supported by NSERC, CIFAR,
  and the Alfred P. Sloan Foundation
author:
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: Alexandre
  full_name: Blais, Alexandre
  last_name: Blais
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Fink JM, Bianchetti R, Baur M, et al. Dressed collective qubit states and the
    Tavis-Cummings model in circuit QED. <i>Physical Review Letters</i>. 2009;103(8).
    doi:<a href="https://doi.org/10.1103/PhysRevLett.103.083601">10.1103/PhysRevLett.103.083601</a>
  apa: Fink, J. M., Bianchetti, R., Baur, M., Göppl, M., Steffen, L., Filipp, S.,
    … Wallraff, A. (2009). Dressed collective qubit states and the Tavis-Cummings
    model in circuit QED. <i>Physical Review Letters</i>. American Physical Society.
    <a href="https://doi.org/10.1103/PhysRevLett.103.083601">https://doi.org/10.1103/PhysRevLett.103.083601</a>
  chicago: Fink, Johannes M, R Bianchetti, Matthias Baur, M Göppl, L. Steffen, Stefan
    Filipp, Peter Leek, Alexandre Blais, and Andreas Wallraff. “Dressed Collective
    Qubit States and the Tavis-Cummings Model in Circuit QED.” <i>Physical Review
    Letters</i>. American Physical Society, 2009. <a href="https://doi.org/10.1103/PhysRevLett.103.083601">https://doi.org/10.1103/PhysRevLett.103.083601</a>.
  ieee: J. M. Fink <i>et al.</i>, “Dressed collective qubit states and the Tavis-Cummings
    model in circuit QED,” <i>Physical Review Letters</i>, vol. 103, no. 8. American
    Physical Society, 2009.
  ista: Fink JM, Bianchetti R, Baur M, Göppl M, Steffen L, Filipp S, Leek P, Blais
    A, Wallraff A. 2009. Dressed collective qubit states and the Tavis-Cummings model
    in circuit QED. Physical Review Letters. 103(8).
  mla: Fink, Johannes M., et al. “Dressed Collective Qubit States and the Tavis-Cummings
    Model in Circuit QED.” <i>Physical Review Letters</i>, vol. 103, no. 8, American
    Physical Society, 2009, doi:<a href="https://doi.org/10.1103/PhysRevLett.103.083601">10.1103/PhysRevLett.103.083601</a>.
  short: J.M. Fink, R. Bianchetti, M. Baur, M. Göppl, L. Steffen, S. Filipp, P. Leek,
    A. Blais, A. Wallraff, Physical Review Letters 103 (2009).
date_created: 2018-12-11T11:53:55Z
date_published: 2009-08-17T00:00:00Z
date_updated: 2021-01-12T06:53:05Z
day: '17'
doi: 10.1103/PhysRevLett.103.083601
extern: 1
intvolume: '       103'
issue: '8'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0812.2651
month: '08'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5350'
quality_controlled: 0
status: public
title: Dressed collective qubit states and the Tavis-Cummings model in circuit QED
type: journal_article
volume: 103
year: '2009'
...
---
_id: '1770'
abstract:
- lang: eng
  text: The quantum state of a superconducting qubit nonresonantly coupled to a transmission
    line resonator can be determined by measuring the quadrature amplitudes of an
    electromagnetic field transmitted through the resonator. We present experiments
    in which we analyze in detail the dynamics of the transmitted field as a function
    of the measurement frequency for both weak continuous and pulsed measurements.
    We find excellent agreement between our data and calculations based on a set of
    Bloch-type differential equations for the cavity field derived from the dispersive
    Jaynes-Cummings Hamiltonian including dissipation. We show that the measured system
    response can be used to construct a measurement operator from which the qubit
    population can be inferred accurately. Such a measurement operator can be used
    in tomographic methods to reconstruct single and multiqubit states in ensemble-averaged
    measurements.
acknowledgement: This work was supported by the SNF Project No. 111899 and ETH Zurich.
  A.B. was supported by NSERC, CIFAR, and the Alfred P. Sloan Foundation
author:
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Alexandre
  full_name: Blais, Alexandre
  last_name: Blais
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Bianchetti R, Filipp S, Baur M, et al. Dynamics of dispersive single-qubit
    readout in circuit quantum electrodynamics. <i>Physical Review A - Atomic, Molecular,
    and Optical Physics</i>. 2009;80(4). doi:<a href="https://doi.org/10.1103/PhysRevA.80.043840">10.1103/PhysRevA.80.043840</a>
  apa: Bianchetti, R., Filipp, S., Baur, M., Fink, J. M., Göppl, M., Leek, P., … Wallraff,
    A. (2009). Dynamics of dispersive single-qubit readout in circuit quantum electrodynamics.
    <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevA.80.043840">https://doi.org/10.1103/PhysRevA.80.043840</a>
  chicago: Bianchetti, R, Stefan Filipp, Matthias Baur, Johannes M Fink, M Göppl,
    Peter Leek, L. Steffen, Alexandre Blais, and Andreas Wallraff. “Dynamics of Dispersive
    Single-Qubit Readout in Circuit Quantum Electrodynamics.” <i>Physical Review A
    - Atomic, Molecular, and Optical Physics</i>. American Physical Society, 2009.
    <a href="https://doi.org/10.1103/PhysRevA.80.043840">https://doi.org/10.1103/PhysRevA.80.043840</a>.
  ieee: R. Bianchetti <i>et al.</i>, “Dynamics of dispersive single-qubit readout
    in circuit quantum electrodynamics,” <i>Physical Review A - Atomic, Molecular,
    and Optical Physics</i>, vol. 80, no. 4. American Physical Society, 2009.
  ista: Bianchetti R, Filipp S, Baur M, Fink JM, Göppl M, Leek P, Steffen L, Blais
    A, Wallraff A. 2009. Dynamics of dispersive single-qubit readout in circuit quantum
    electrodynamics. Physical Review A - Atomic, Molecular, and Optical Physics. 80(4).
  mla: Bianchetti, R., et al. “Dynamics of Dispersive Single-Qubit Readout in Circuit
    Quantum Electrodynamics.” <i>Physical Review A - Atomic, Molecular, and Optical
    Physics</i>, vol. 80, no. 4, American Physical Society, 2009, doi:<a href="https://doi.org/10.1103/PhysRevA.80.043840">10.1103/PhysRevA.80.043840</a>.
  short: R. Bianchetti, S. Filipp, M. Baur, J.M. Fink, M. Göppl, P. Leek, L. Steffen,
    A. Blais, A. Wallraff, Physical Review A - Atomic, Molecular, and Optical Physics
    80 (2009).
date_created: 2018-12-11T11:53:55Z
date_published: 2009-10-30T00:00:00Z
date_updated: 2021-01-12T06:53:05Z
day: '30'
doi: 10.1103/PhysRevA.80.043840
extern: 1
intvolume: '        80'
issue: '4'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0907.2549
month: '10'
oa: 1
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_status: published
publisher: American Physical Society
publist_id: '5349'
quality_controlled: 0
status: public
title: Dynamics of dispersive single-qubit readout in circuit quantum electrodynamics
type: journal_article
volume: 80
year: '2009'
...
---
_id: '1771'
abstract:
- lang: eng
  text: The exceptionally strong coupling realizable between superconducting qubits
    and photons stored in an on-chip microwave resonator allows for the detailed study
    of matter-light interactions in the realm of circuit quantum electrodynamics (QED).
    Here we investigate the resonant interaction between a single transmon-type multilevel
    artificial atom and weak thermal and coherent fields. We explore up to three photon
    dressed states of the coupled system in a linear response heterodyne transmission
    measurement. The results are in good quantitative agreement with a generalized
    Jaynes-Cummings model. Our data indicate that the role of thermal fields in resonant
    cavity QED can be studied in detail using superconducting circuits.
acknowledgement: Nobel Foundation
author:
- first_name: Johannes M
  full_name: Johannes Fink
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: Matthias
  full_name: Baur, Matthias P
  last_name: Baur
- first_name: R
  full_name: Bianchetti, R
  last_name: Bianchetti
- first_name: Stefan
  full_name: Filipp, Stefan
  last_name: Filipp
- first_name: M
  full_name: Göppl, M
  last_name: Göppl
- first_name: Peter
  full_name: Leek, Peter J
  last_name: Leek
- first_name: L.
  full_name: Steffen, L. Kraig
  last_name: Steffen
- first_name: Alexandre
  full_name: Blais, Alexandre
  last_name: Blais
- first_name: Andreas
  full_name: Wallraff, Andreas
  last_name: Wallraff
citation:
  ama: Fink JM, Baur M, Bianchetti R, et al. Thermal excitation of multi-photon dressed
    states in circuit quantum electrodynamics. <i>Physica Scripta T</i>. 2009;T137.
    doi:<a href="https://doi.org/10.1088/0031-8949/2009/T137/014013">10.1088/0031-8949/2009/T137/014013</a>
  apa: Fink, J. M., Baur, M., Bianchetti, R., Filipp, S., Göppl, M., Leek, P., … Wallraff,
    A. (2009). Thermal excitation of multi-photon dressed states in circuit quantum
    electrodynamics. <i>Physica Scripta T</i>. IOP Publishing Ltd. <a href="https://doi.org/10.1088/0031-8949/2009/T137/014013">https://doi.org/10.1088/0031-8949/2009/T137/014013</a>
  chicago: Fink, Johannes M, Matthias Baur, R Bianchetti, Stefan Filipp, M Göppl,
    Peter Leek, L. Steffen, Alexandre Blais, and Andreas Wallraff. “Thermal Excitation
    of Multi-Photon Dressed States in Circuit Quantum Electrodynamics.” <i>Physica
    Scripta T</i>. IOP Publishing Ltd., 2009. <a href="https://doi.org/10.1088/0031-8949/2009/T137/014013">https://doi.org/10.1088/0031-8949/2009/T137/014013</a>.
  ieee: J. M. Fink <i>et al.</i>, “Thermal excitation of multi-photon dressed states
    in circuit quantum electrodynamics,” <i>Physica Scripta T</i>, vol. T137. IOP
    Publishing Ltd., 2009.
  ista: Fink JM, Baur M, Bianchetti R, Filipp S, Göppl M, Leek P, Steffen L, Blais
    A, Wallraff A. 2009. Thermal excitation of multi-photon dressed states in circuit
    quantum electrodynamics. Physica Scripta T. T137.
  mla: Fink, Johannes M., et al. “Thermal Excitation of Multi-Photon Dressed States
    in Circuit Quantum Electrodynamics.” <i>Physica Scripta T</i>, vol. T137, IOP
    Publishing Ltd., 2009, doi:<a href="https://doi.org/10.1088/0031-8949/2009/T137/014013">10.1088/0031-8949/2009/T137/014013</a>.
  short: J.M. Fink, M. Baur, R. Bianchetti, S. Filipp, M. Göppl, P. Leek, L. Steffen,
    A. Blais, A. Wallraff, Physica Scripta T T137 (2009).
date_created: 2018-12-11T11:53:55Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T06:53:06Z
day: '01'
doi: 10.1088/0031-8949/2009/T137/014013
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0911.3797
month: '01'
oa: 1
publication: Physica Scripta T
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '5348'
quality_controlled: 0
status: public
title: Thermal excitation of multi-photon dressed states in circuit quantum electrodynamics
type: journal_article
volume: T137
year: '2009'
...
---
_id: '17719'
abstract:
- lang: eng
  text: We propose to use a simple observable, the fractional area of "hot spots"
    in weak gravitational lensing mass maps, which are detected with high significance,
    to determine background cosmological parameters. Because these high-convergence
    regions are directly related to the physical nonlinear structures of the universe,
    they derive cosmological information mainly from the nonlinear regime of density
    fluctuations. We show that in combination with future cosmic microwave background
    anisotropy measurements, this method can place constraints on cosmological parameters
    that are comparable to those from the redshift distribution of galaxy cluster
    abundances. The main advantage of the statistic proposed in this paper is that
    projection effects, normally the main source of uncertainty when determining the
    presence and the mass of a galaxy cluster, here serve as a source of information.
article_processing_charge: No
article_type: original
author:
- first_name: Sheng
  full_name: Wang, Sheng
  last_name: Wang
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
- first_name: Morgan
  full_name: May, Morgan
  last_name: May
citation:
  ama: Wang S, Haiman Z, May M. Constraining cosmology with high-convergence regions
    in weak lensing surveys. <i>The Astrophysical Journal</i>. 2009;691(1):547-559.
    doi:<a href="https://doi.org/10.1088/0004-637x/691/1/547">10.1088/0004-637x/691/1/547</a>
  apa: Wang, S., Haiman, Z., &#38; May, M. (2009). Constraining cosmology with high-convergence
    regions in weak lensing surveys. <i>The Astrophysical Journal</i>. American Astronomical
    Society. <a href="https://doi.org/10.1088/0004-637x/691/1/547">https://doi.org/10.1088/0004-637x/691/1/547</a>
  chicago: Wang, Sheng, Zoltán Haiman, and Morgan May. “Constraining Cosmology with
    High-Convergence Regions in Weak Lensing Surveys.” <i>The Astrophysical Journal</i>.
    American Astronomical Society, 2009. <a href="https://doi.org/10.1088/0004-637x/691/1/547">https://doi.org/10.1088/0004-637x/691/1/547</a>.
  ieee: S. Wang, Z. Haiman, and M. May, “Constraining cosmology with high-convergence
    regions in weak lensing surveys,” <i>The Astrophysical Journal</i>, vol. 691,
    no. 1. American Astronomical Society, pp. 547–559, 2009.
  ista: Wang S, Haiman Z, May M. 2009. Constraining cosmology with high-convergence
    regions in weak lensing surveys. The Astrophysical Journal. 691(1), 547–559.
  mla: Wang, Sheng, et al. “Constraining Cosmology with High-Convergence Regions in
    Weak Lensing Surveys.” <i>The Astrophysical Journal</i>, vol. 691, no. 1, American
    Astronomical Society, 2009, pp. 547–59, doi:<a href="https://doi.org/10.1088/0004-637x/691/1/547">10.1088/0004-637x/691/1/547</a>.
  short: S. Wang, Z. Haiman, M. May, The Astrophysical Journal 691 (2009) 547–559.
date_created: 2024-09-06T09:03:38Z
date_published: 2009-01-15T00:00:00Z
date_updated: 2024-09-25T13:44:05Z
day: '15'
doi: 10.1088/0004-637x/691/1/547
extern: '1'
intvolume: '       691'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1088/0004-637x/691/1/547
month: '01'
oa: 1
oa_version: Published Version
page: 547-559
publication: The Astrophysical Journal
publication_identifier:
  issn:
  - 0004-637X
  - 1538-4357
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Constraining cosmology with high-convergence regions in weak lensing surveys
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 691
year: '2009'
...
---
_id: '17735'
abstract:
- lang: eng
  text: 'The supermassive black holes (SMBHs) massive enough to power the bright redshift
    ~6 quasars observed in the Sloan Digital Sky Survey (SDSS) are thought to have
    assembled by mergers and/or gas accretion from less massive "seed" BHs. If the
    seeds are the ~100 Msol remnant BHs from the first generation of stars, they must
    be in place well before redshift z=6, and must avoid being ejected from their
    parent proto-galaxies by the large (few hundred km/s) kicks they suffer from gravitational-radiation
    induced recoil during mergers with other BHs. We simulate the SMBH mass function
    at redshift z=6 using dark matter (DM) halo merger trees, coupled with a prescription
    for the halo occupation fraction, accretion histories, and radial recoil trajectories
    of the growing BHs. Our purpose is (i) to map out plausible scenarios for successful
    assembly of the z~6 quasar BHs by exploring a wide region of parameter space,
    and (ii) to predict the rate of low-frequency gravitational wave events detectable
    by the Laser Interferometer Space Antenna (LISA) for each such scenario. Our main
    findings are as follows: (1) ~100 Msol seed BHs can grow into the SDSS quasar
    BHs without super--Eddington accretion, but only if they form in minihalos by
    z~30 and subsequently accrete ~60% of the time; (2) the scenarios with optimistic
    assumptions required to explain the SDSS quasar BHs overproduce the mass density
    in lower--mass (10^5 to 10^7 Msol) SMBHs by a factor of 100-1000, unless seeds
    stop forming, or accrete at a severely diminished rates or duty cycles (e.g. due
    to feedback), at z < 20-30. We also present several successful assembly models
    and their LISA detection rates, including a "maximal" model that gives the highest
    rate (~30/yr at z~6) without overproducing the total SMBH density.'
article_processing_charge: No
article_type: original
author:
- first_name: Takamitsu
  full_name: Tanaka, Takamitsu
  last_name: Tanaka
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
citation:
  ama: Tanaka T, Haiman Z. The assembly of supermassive black holes at high redshifts.
    <i>The Astrophysical Journal</i>. 2009;696(2):1798-1822. doi:<a href="https://doi.org/10.1088/0004-637x/696/2/1798">10.1088/0004-637x/696/2/1798</a>
  apa: Tanaka, T., &#38; Haiman, Z. (2009). The assembly of supermassive black holes
    at high redshifts. <i>The Astrophysical Journal</i>. American Astronomical Society.
    <a href="https://doi.org/10.1088/0004-637x/696/2/1798">https://doi.org/10.1088/0004-637x/696/2/1798</a>
  chicago: Tanaka, Takamitsu, and Zoltán Haiman. “The Assembly of Supermassive Black
    Holes at High Redshifts.” <i>The Astrophysical Journal</i>. American Astronomical
    Society, 2009. <a href="https://doi.org/10.1088/0004-637x/696/2/1798">https://doi.org/10.1088/0004-637x/696/2/1798</a>.
  ieee: T. Tanaka and Z. Haiman, “The assembly of supermassive black holes at high
    redshifts,” <i>The Astrophysical Journal</i>, vol. 696, no. 2. American Astronomical
    Society, pp. 1798–1822, 2009.
  ista: Tanaka T, Haiman Z. 2009. The assembly of supermassive black holes at high
    redshifts. The Astrophysical Journal. 696(2), 1798–1822.
  mla: Tanaka, Takamitsu, and Zoltán Haiman. “The Assembly of Supermassive Black Holes
    at High Redshifts.” <i>The Astrophysical Journal</i>, vol. 696, no. 2, American
    Astronomical Society, 2009, pp. 1798–822, doi:<a href="https://doi.org/10.1088/0004-637x/696/2/1798">10.1088/0004-637x/696/2/1798</a>.
  short: T. Tanaka, Z. Haiman, The Astrophysical Journal 696 (2009) 1798–1822.
date_created: 2024-09-06T09:19:25Z
date_published: 2009-05-10T00:00:00Z
date_updated: 2024-09-26T13:45:27Z
day: '10'
doi: 10.1088/0004-637x/696/2/1798
extern: '1'
intvolume: '       696'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1088/0004-637x/696/2/1798
month: '05'
oa: 1
oa_version: Published Version
page: 1798-1822
publication: The Astrophysical Journal
publication_identifier:
  issn:
  - 0004-637X
  - 1538-4357
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: The assembly of supermassive black holes at high redshifts
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 696
year: '2009'
...
---
_id: '17736'
abstract:
- lang: eng
  text: 'We discuss currently available observational constraints on the reionization
    history of the intergalactic medium (IGM), and the extent to which accreting black
    holes (BHs) and stars can help account for these observations. We argue, based
    on the combined statistics of Lyman α and β absorption in quasar spectra, that
    the IGM contains a significant amount of neutral hydrogen with nH I/nH ≳ 0.1.
    On the other hand, we argue, based on the lack of a strong evolution in the observed
    abundance of Lyman α emitting galaxies beyond z ∼ 5.5, that the mean neutral hydrogen
    fraction cannot exceed nH I/nH ≈ 0.3 at the same redshift. We conclude that the
    IGM is experiencing rapid ionization at redshift z ∼ 6. We find that quasar BHs,
    including faint ones that are individually below the detection thresholds of existing
    optical and X-ray surveys, are unlikely to drive the evolution of the neutral
    fraction around this epoch, because they would over-produce the present-day soft
    X-ray background. On the other hand, the seeds of the z ∼ 6 quasar BHs likely
    appeared at much earlier epochs (z ∼ 20), and produced hard ionizing radiation
    by accretion. These early BHs are promising candidates to account for the high
    redshift (z ∼ 15) ionization implied by the recent cosmic microwave anisotropy
    data from WMAP. Using a model for the growth of BHs by accretion and mergers in
    a hierarchical cosmology, we suggest that the early growth of quasars must include
    a super-Eddington growth phase, and that, although not yet optically identified,
    the FIRST radio survey may have already detected several thousand > 10^8 M⊙ BHs
    at z > 6. '
article_processing_charge: No
author:
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
citation:
  ama: 'Haiman Z. Probing the reionization history of the Universe. In: Livio M, Casertano
    S, eds. <i>Planets to Cosmology. Essential Science in the Final Years of the Hubble
    Space Telescope</i>. Vol 18.  Space Telescope Science Institute Symposium Series.
    Baltimore: Cambridge University Press; 2009:157-173. doi:<a href="https://doi.org/10.1017/cbo9780511536328.014">10.1017/cbo9780511536328.014</a>'
  apa: 'Haiman, Z. (2009). Probing the reionization history of the Universe. In M.
    Livio &#38; S. Casertano (Eds.), <i>Planets to Cosmology. Essential Science in
    the Final Years of the Hubble Space Telescope</i> (Vol. 18, pp. 157–173). Baltimore:
    Cambridge University Press. <a href="https://doi.org/10.1017/cbo9780511536328.014">https://doi.org/10.1017/cbo9780511536328.014</a>'
  chicago: 'Haiman, Zoltán. “Probing the Reionization History of the Universe.” In
    <i>Planets to Cosmology. Essential Science in the Final Years of the Hubble Space
    Telescope</i>, edited by Mario Livio and Stefano Casertano, 18:157–73.  Space
    Telescope Science Institute Symposium Series. Baltimore: Cambridge University
    Press, 2009. <a href="https://doi.org/10.1017/cbo9780511536328.014">https://doi.org/10.1017/cbo9780511536328.014</a>.'
  ieee: 'Z. Haiman, “Probing the reionization history of the Universe,” in <i>Planets
    to Cosmology. Essential Science in the Final Years of the Hubble Space Telescope</i>,
    vol. 18, M. Livio and S. Casertano, Eds. Baltimore: Cambridge University Press,
    2009, pp. 157–173.'
  ista: 'Haiman Z. 2009.Probing the reionization history of the Universe. In: Planets
    to Cosmology. Essential Science in the Final Years of the Hubble Space Telescope.
    vol. 18, 157–173.'
  mla: Haiman, Zoltán. “Probing the Reionization History of the Universe.” <i>Planets
    to Cosmology. Essential Science in the Final Years of the Hubble Space Telescope</i>,
    edited by Mario Livio and Stefano Casertano, vol. 18, Cambridge University Press,
    2009, pp. 157–73, doi:<a href="https://doi.org/10.1017/cbo9780511536328.014">10.1017/cbo9780511536328.014</a>.
  short: Z. Haiman, in:, M. Livio, S. Casertano (Eds.), Planets to Cosmology. Essential
    Science in the Final Years of the Hubble Space Telescope, Cambridge University
    Press, Baltimore, 2009, pp. 157–173.
conference:
  end_date: 2004-05-06
  location: Baltimore, MD, United States
  name: Proceedings of the Space Telescope Science Institute Symposium
  start_date: 2004-05-03
date_created: 2024-09-06T09:20:03Z
date_published: 2009-08-17T00:00:00Z
date_updated: 2024-09-30T07:02:44Z
day: '17'
doi: 10.1017/cbo9780511536328.014
editor:
- first_name: Mario
  full_name: Livio, Mario
  last_name: Livio
- first_name: Stefano
  full_name: Casertano, Stefano
  last_name: Casertano
extern: '1'
intvolume: '        18'
language:
- iso: eng
main_file_link:
- url: https://doi.org/10.1017/CBO9780511536328.014
month: '08'
oa_version: None
page: 157-173
place: Baltimore
publication: Planets to Cosmology. Essential Science in the Final Years of the Hubble
  Space Telescope
publication_identifier:
  eisbn:
  - '9780511536328'
  isbn:
  - '9780521847582'
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
series_title: ' Space Telescope Science Institute Symposium Series'
status: public
title: Probing the reionization history of the Universe
type: book_chapter
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 18
year: '2009'
...
---
_id: '17764'
abstract:
- lang: eng
  text: Supermassive black hole binaries (SMBHBs) with masses in the mass range ∼(10^4–10^7) M⊙/(1
    + z), produced in galaxy mergers, are thought to complete their coalescence due
    to the emission of gravitational waves (GWs). The anticipated detection of the
    GWs by the future Laser Interferometric Space Antenna (LISA) will constitute a
    milestone for fundamental physics and astrophysics. While the GW signatures themselves
    will provide a treasure trove of information, if the source can be securely identified
    in electromagnetic (EM) bands, this would open up entirely new scientific opportunities,
    to probe fundamental physics, astrophysics and cosmology. We discuss several ideas,
    involving wide-field telescopes, that may be useful in locating electromagnetic
    counterparts to SMBHBs detected by LISA. In particular, the binary may produce
    a variable electromagnetic flux, such as a roughly periodic signal due to the
    orbital motion prior to coalescence, or a prompt transient signal caused by shocks
    in the circumbinary disc when the SMBHB recoils and 'shakes' the disc. We discuss
    whether these time-variable EM signatures may be detectable, and how they can
    help in identifying a unique counterpart within the localization errors provided
    by LISA. We also discuss a possibility of identifying a population of coalescing
    SMBHBs statistically, in a deep optical survey for periodically variable sources,
    before LISA detects the GWs directly. The discovery of such sources would confirm
    that gas is present in the vicinity and is being perturbed by the SMBHB—serving
    as a proof of concept for eventually finding actual LISA counterparts.
article_number: '094032'
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
- first_name: Bence
  full_name: Kocsis, Bence
  last_name: Kocsis
- first_name: Kristen
  full_name: Menou, Kristen
  last_name: Menou
- first_name: Zoltán
  full_name: Lippai, Zoltán
  last_name: Lippai
- first_name: Zsolt
  full_name: Frei, Zsolt
  last_name: Frei
citation:
  ama: Haiman Z, Kocsis B, Menou K, Lippai Z, Frei Z. Identifying decaying supermassive
    black hole binaries from their variable electromagnetic emission. <i>Classical
    and Quantum Gravity</i>. 2009;26(9). doi:<a href="https://doi.org/10.1088/0264-9381/26/9/094032">10.1088/0264-9381/26/9/094032</a>
  apa: Haiman, Z., Kocsis, B., Menou, K., Lippai, Z., &#38; Frei, Z. (2009). Identifying
    decaying supermassive black hole binaries from their variable electromagnetic
    emission. <i>Classical and Quantum Gravity</i>. IOP Publishing. <a href="https://doi.org/10.1088/0264-9381/26/9/094032">https://doi.org/10.1088/0264-9381/26/9/094032</a>
  chicago: Haiman, Zoltán, Bence Kocsis, Kristen Menou, Zoltán Lippai, and Zsolt Frei.
    “Identifying Decaying Supermassive Black Hole Binaries from Their Variable Electromagnetic
    Emission.” <i>Classical and Quantum Gravity</i>. IOP Publishing, 2009. <a href="https://doi.org/10.1088/0264-9381/26/9/094032">https://doi.org/10.1088/0264-9381/26/9/094032</a>.
  ieee: Z. Haiman, B. Kocsis, K. Menou, Z. Lippai, and Z. Frei, “Identifying decaying
    supermassive black hole binaries from their variable electromagnetic emission,”
    <i>Classical and Quantum Gravity</i>, vol. 26, no. 9. IOP Publishing, 2009.
  ista: Haiman Z, Kocsis B, Menou K, Lippai Z, Frei Z. 2009. Identifying decaying
    supermassive black hole binaries from their variable electromagnetic emission.
    Classical and Quantum Gravity. 26(9), 094032.
  mla: Haiman, Zoltán, et al. “Identifying Decaying Supermassive Black Hole Binaries
    from Their Variable Electromagnetic Emission.” <i>Classical and Quantum Gravity</i>,
    vol. 26, no. 9, 094032, IOP Publishing, 2009, doi:<a href="https://doi.org/10.1088/0264-9381/26/9/094032">10.1088/0264-9381/26/9/094032</a>.
  short: Z. Haiman, B. Kocsis, K. Menou, Z. Lippai, Z. Frei, Classical and Quantum
    Gravity 26 (2009).
date_created: 2024-09-06T09:51:19Z
date_published: 2009-05-07T00:00:00Z
date_updated: 2024-09-30T09:19:04Z
day: '07'
doi: 10.1088/0264-9381/26/9/094032
extern: '1'
intvolume: '        26'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1088/0264-9381/26/9/094032
month: '05'
oa: 1
oa_version: Published Version
publication: Classical and Quantum Gravity
publication_identifier:
  issn:
  - 0264-9381
  - 1361-6382
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identifying decaying supermassive black hole binaries from their variable electromagnetic
  emission
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 26
year: '2009'
...
---
_id: '17765'
abstract:
- lang: eng
  text: 'Scaling relations among galaxy cluster observables, which will become available
    in large future samples of galaxy clusters, could be used to constrain not only
    cluster structure, but also cosmology. We study the utility of this approach,
    employing a physically motivated parametric model to describe cluster structure
    and applying it to the expected relation between the Sunyaev–Zel''dovich decrement
    (Sν) and the emission-weighted X-ray temperature (Tew). The slope and normalization
    of the entropy profile, the concentration of the dark matter potential, the pressure
    at the virial radius and the level of non-thermal pressure support as well as
    the mass and redshift dependence of these quantities are described by free parameters.
    With a suitable choice of fiducial parameter values, the cluster model satisfies
    several existing observational constraints. We employ a Fisher matrix approach
    to estimate the joint errors on cosmological and cluster structure parameters
    from a measurement of Sν versus Tew in a future survey. We find that different
    cosmological parameters affect the scaling relation differently: predominantly
    through the baryon fraction (Ωm and Ωb), the virial overdensity (w0 and wa for
    low-z clusters) and the angular diameter distance (w0 and wa for high-z clusters;
    ΩDE and h). We find that the cosmology constraints from the scaling relation are
    comparable to those expected from the number counts (dN/dz) of the same clusters.
    The scaling-relation approach is relatively insensitive to selection effects and
    it offers a valuable consistency check; combining the information from the scaling
    relation and dN/dz is also useful to break parameter degeneracies and help disentangle
    cluster physics from cosmology. Our work suggests that scaling relations should
    be a useful component in extracting cosmological information from large future
    cluster surveys.'
article_processing_charge: No
article_type: original
author:
- first_name: Cien
  full_name: Shang, Cien
  last_name: Shang
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
- first_name: Licia
  full_name: Verde, Licia
  last_name: Verde
citation:
  ama: Shang C, Haiman Z, Verde L. Probing cosmology and galaxy cluster structure
    with the Sunyaev-Zel’dovich decrement versus X-ray temperature scaling relation.
    <i>Monthly Notices of the Royal Astronomical Society</i>. 2009;400(2):1085-1104.
    doi:<a href="https://doi.org/10.1111/j.1365-2966.2009.15527.x">10.1111/j.1365-2966.2009.15527.x</a>
  apa: Shang, C., Haiman, Z., &#38; Verde, L. (2009). Probing cosmology and galaxy
    cluster structure with the Sunyaev-Zel’dovich decrement versus X-ray temperature
    scaling relation. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press. <a href="https://doi.org/10.1111/j.1365-2966.2009.15527.x">https://doi.org/10.1111/j.1365-2966.2009.15527.x</a>
  chicago: Shang, Cien, Zoltán Haiman, and Licia Verde. “Probing Cosmology and Galaxy
    Cluster Structure with the Sunyaev-Zel’dovich Decrement versus X-Ray Temperature
    Scaling Relation.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford
    University Press, 2009. <a href="https://doi.org/10.1111/j.1365-2966.2009.15527.x">https://doi.org/10.1111/j.1365-2966.2009.15527.x</a>.
  ieee: C. Shang, Z. Haiman, and L. Verde, “Probing cosmology and galaxy cluster structure
    with the Sunyaev-Zel’dovich decrement versus X-ray temperature scaling relation,”
    <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 400, no. 2. Oxford
    University Press, pp. 1085–1104, 2009.
  ista: Shang C, Haiman Z, Verde L. 2009. Probing cosmology and galaxy cluster structure
    with the Sunyaev-Zel’dovich decrement versus X-ray temperature scaling relation.
    Monthly Notices of the Royal Astronomical Society. 400(2), 1085–1104.
  mla: Shang, Cien, et al. “Probing Cosmology and Galaxy Cluster Structure with the
    Sunyaev-Zel’dovich Decrement versus X-Ray Temperature Scaling Relation.” <i>Monthly
    Notices of the Royal Astronomical Society</i>, vol. 400, no. 2, Oxford University
    Press, 2009, pp. 1085–104, doi:<a href="https://doi.org/10.1111/j.1365-2966.2009.15527.x">10.1111/j.1365-2966.2009.15527.x</a>.
  short: C. Shang, Z. Haiman, L. Verde, Monthly Notices of the Royal Astronomical
    Society 400 (2009) 1085–1104.
date_created: 2024-09-06T09:51:57Z
date_published: 2009-11-12T00:00:00Z
date_updated: 2024-09-30T09:24:18Z
day: '12'
doi: 10.1111/j.1365-2966.2009.15527.x
extern: '1'
intvolume: '       400'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/j.1365-2966.2009.15527.x
month: '11'
oa: 1
oa_version: Published Version
page: 1085-1104
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  issn:
  - 0035-8711
  - 1365-2966
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Probing cosmology and galaxy cluster structure with the Sunyaev-Zel'dovich
  decrement versus X-ray temperature scaling relation
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 400
year: '2009'
...
---
_id: '17769'
abstract:
- lang: eng
  text: Arguably the best hope of understanding the tail end of the re-ionization
    of the intergalactic medium (IGM) at redshift z > 6 is through the detection and
    characterization of the Gunn–Peterson damping wing absorption of the IGM in bright
    quasar spectra. However, the use of quasar spectra to measure the IGM damping
    wing requires a model of the quasar's intrinsic Lyman α emission line. Here we
    quantify the uncertainties in the intrinsic line shapes, and how those uncertainties
    affect the determination of the IGM neutral fraction. We have assembled a catalogue
    of high-resolution Hubble Space Telescope spectra of the emission lines of unobscured
    low-redshift quasars, and have characterized the variance in the shapes of their
    lines. We then add simulated absorption from the high-redshift IGM to these quasar
    spectra in order to determine the corresponding uncertainties in re-ionization
    constraints using current and future samples of z > 6 quasar spectra. We find
    that, if the redshift of the Lyman α emission line is presumed to coincide with
    the systemic redshift determined from metal lines, the inferred IGM neutral fraction
    is systematically biased to low values due to a systematic blueshift of the Lyman
    α line relative to the metal lines. If a similar blueshift persists in quasars
    at z > 6, this bias strengthens previous claims of a significant neutral hydrogen
    fraction at z≈ 6. The bias can be reduced by including a Lyman α blueshift in
    the modelling procedure, or by excising wavelengths near the Lyman α line centre
    from the modelling. Intrinsic Lyman α line shape variations still induce significant
    scatter in the inferred xIGM values. Nevertheless, this scatter still allows a
    robust distinction between a highly ionized (xIGM∼ 10−3) and a neutral (xIGM=
    1) IGM with even a few bright quasars. We conclude that if the variations of the
    intrinsic Lyman α emission line shapes in high-z quasars are similar to those
    at low-z, this variation will not limit the usefulness of quasar spectra in probing
    re-ionization.
article_processing_charge: No
article_type: original
author:
- first_name: R. H.
  full_name: Kramer, R. H.
  last_name: Kramer
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
citation:
  ama: 'Kramer RH, Haiman Z. Probing re-ionization with quasar spectra: The impact
    of the intrinsic Lyman α emission line shape uncertainty. <i>Monthly Notices of
    the Royal Astronomical Society</i>. 2009;400(3):1493-1511. doi:<a href="https://doi.org/10.1111/j.1365-2966.2009.15552.x">10.1111/j.1365-2966.2009.15552.x</a>'
  apa: 'Kramer, R. H., &#38; Haiman, Z. (2009). Probing re-ionization with quasar
    spectra: The impact of the intrinsic Lyman α emission line shape uncertainty.
    <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press.
    <a href="https://doi.org/10.1111/j.1365-2966.2009.15552.x">https://doi.org/10.1111/j.1365-2966.2009.15552.x</a>'
  chicago: 'Kramer, R. H., and Zoltán Haiman. “Probing Re-Ionization with Quasar Spectra:
    The Impact of the Intrinsic Lyman α Emission Line Shape Uncertainty.” <i>Monthly
    Notices of the Royal Astronomical Society</i>. Oxford University Press, 2009.
    <a href="https://doi.org/10.1111/j.1365-2966.2009.15552.x">https://doi.org/10.1111/j.1365-2966.2009.15552.x</a>.'
  ieee: 'R. H. Kramer and Z. Haiman, “Probing re-ionization with quasar spectra: The
    impact of the intrinsic Lyman α emission line shape uncertainty,” <i>Monthly Notices
    of the Royal Astronomical Society</i>, vol. 400, no. 3. Oxford University Press,
    pp. 1493–1511, 2009.'
  ista: 'Kramer RH, Haiman Z. 2009. Probing re-ionization with quasar spectra: The
    impact of the intrinsic Lyman α emission line shape uncertainty. Monthly Notices
    of the Royal Astronomical Society. 400(3), 1493–1511.'
  mla: 'Kramer, R. H., and Zoltán Haiman. “Probing Re-Ionization with Quasar Spectra:
    The Impact of the Intrinsic Lyman α Emission Line Shape Uncertainty.” <i>Monthly
    Notices of the Royal Astronomical Society</i>, vol. 400, no. 3, Oxford University
    Press, 2009, pp. 1493–511, doi:<a href="https://doi.org/10.1111/j.1365-2966.2009.15552.x">10.1111/j.1365-2966.2009.15552.x</a>.'
  short: R.H. Kramer, Z. Haiman, Monthly Notices of the Royal Astronomical Society
    400 (2009) 1493–1511.
date_created: 2024-09-06T09:58:12Z
date_published: 2009-12-02T00:00:00Z
date_updated: 2024-09-30T09:48:06Z
day: '02'
doi: 10.1111/j.1365-2966.2009.15552.x
extern: '1'
intvolume: '       400'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/j.1365-2966.2009.15552.x
month: '12'
oa: 1
oa_version: Published Version
page: 1493-1511
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  issn:
  - 0035-8711
  - 1365-2966
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Probing re-ionization with quasar spectra: The impact of the intrinsic Lyman
  α emission line shape uncertainty'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 400
year: '2009'
...
