--- OA_place: publisher OA_type: hybrid _id: '19670' abstract: - lang: eng text: “Pasta alla Cacio e pepe” is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect texture and creaminess of the sauce can be challenging. In this study, we systematically explore the phase behavior of Cacio e pepe sauce, focusing on its stability at increasing temperatures for various proportions of cheese, water, and starch. We identify starch concentration as the key factor influencing sauce stability, with direct implications for practical cooking. Specifically, we delineate a regime where starch concentrations below 1% (relative to cheese mass) lead to the formation of system-wide clumps, a condition determining what we term the “Mozzarella Phase” and corresponding to an unpleasant and separated sauce. Additionally, we examine the impact of cheese concentration relative to water at a fixed starch level, observing a lower critical solution temperature that we theoretically rationalized by means of a minimal effective free-energy model. We further analyze the effect of a less traditional stabilizer, trisodium citrate, and observe a sharp transition from the Mozzarella Phase to a completely smooth and stable sauce, in contrast to starch-stabilized mixtures, where the transition is more gradual. Finally, we present a scientifically optimized recipe based on our findings, enabling a consistently flawless execution of this classic dish. acknowledgement: he authors thank Frank Jülicher, for supporting the initiative and stimulating discussions. We thank Tetsuya Spippayashi for enlightening clarifications on the historical origins of Cacio e pepe and Giuseppe Ricchitelli for helping with the construction of the experimental apparatus. We further thank Martina Gaiba, Alessandro Gaiba, John D. Treado, Virginia Lepore, Eleonora Nanu, Julia Kirsch, Lara Koehler, Burak Budanur, Irina Pi-Jaumà, Elizabeth Brückner, M.J. Franco Oñate, Giorgio Nicoletti, and Marco Salvalaglio for their support and for eating up the sample leftovers. Finally, we thank Simone Frau for taking the photograph in Fig. 1(a). article_number: '044122' article_processing_charge: Yes (in subscription journal) article_type: original arxiv: 1 author: - first_name: G. full_name: Bartolucci, G. last_name: Bartolucci - first_name: D. M. full_name: Busiello, D. M. last_name: Busiello - first_name: M. full_name: Ciarchi, M. last_name: Ciarchi - first_name: A. full_name: Corticelli, A. last_name: Corticelli - first_name: I. full_name: Di Terlizzi, I. last_name: Di Terlizzi - first_name: Fabrizio full_name: Olmeda, Fabrizio id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689 last_name: Olmeda - first_name: D. full_name: Revignas, D. last_name: Revignas - first_name: V. M. full_name: Schimmenti, V. M. last_name: Schimmenti citation: ama: Bartolucci G, Busiello DM, Ciarchi M, et al. Phase behavior of Cacio e Pepe sauce. Physics of Fluids. 2025;37(4). doi:10.1063/5.0255841 apa: Bartolucci, G., Busiello, D. M., Ciarchi, M., Corticelli, A., Di Terlizzi, I., Olmeda, F., … Schimmenti, V. M. (2025). Phase behavior of Cacio e Pepe sauce. Physics of Fluids. AIP Publishing. https://doi.org/10.1063/5.0255841 chicago: Bartolucci, G., D. M. Busiello, M. Ciarchi, A. Corticelli, I. Di Terlizzi, Fabrizio Olmeda, D. Revignas, and V. M. Schimmenti. “Phase Behavior of Cacio e Pepe Sauce.” Physics of Fluids. AIP Publishing, 2025. https://doi.org/10.1063/5.0255841. ieee: G. Bartolucci et al., “Phase behavior of Cacio e Pepe sauce,” Physics of Fluids, vol. 37, no. 4. AIP Publishing, 2025. ista: Bartolucci G, Busiello DM, Ciarchi M, Corticelli A, Di Terlizzi I, Olmeda F, Revignas D, Schimmenti VM. 2025. Phase behavior of Cacio e Pepe sauce. Physics of Fluids. 37(4), 044122. mla: Bartolucci, G., et al. “Phase Behavior of Cacio e Pepe Sauce.” Physics of Fluids, vol. 37, no. 4, 044122, AIP Publishing, 2025, doi:10.1063/5.0255841. short: G. Bartolucci, D.M. Busiello, M. Ciarchi, A. Corticelli, I. Di Terlizzi, F. Olmeda, D. Revignas, V.M. Schimmenti, Physics of Fluids 37 (2025). date_created: 2025-05-11T22:02:40Z date_published: 2025-04-01T00:00:00Z date_updated: 2026-04-28T13:24:53Z day: '01' ddc: - '530' department: - _id: EdHa doi: 10.1063/5.0255841 external_id: arxiv: - '2501.00536' isi: - '001482986200001' file: - access_level: open_access checksum: 242d05898aa0a2348b9c108747adb5ce content_type: application/pdf creator: dernst date_created: 2025-05-12T09:31:22Z date_updated: 2025-05-12T09:31:22Z file_id: '19681' file_name: 2025_PhysicsFluids_Bartolucci.pdf file_size: 4926853 relation: main_file success: 1 file_date_updated: 2025-05-12T09:31:22Z has_accepted_license: '1' intvolume: ' 37' isi: 1 issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Physics of Fluids publication_identifier: eissn: - 1089-7666 issn: - 1070-6631 publication_status: published publisher: AIP Publishing quality_controlled: '1' related_material: link: - description: News on ISTA relation: press_release url: https://ista.ac.at/en/news/2025-ig-nobel-prize-for-perfect-pasta-sauce/ scopus_import: '1' status: public title: Phase behavior of Cacio e Pepe sauce tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 37 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '20082' abstract: - lang: eng text: Efficient immune responses rely on the capacity of leukocytes to traverse diverse and complex tissues. To meet such changing environmental conditions, leukocytes usually adopt an ameboid configuration, using their forward-positioned nucleus as a probe to identify and follow the path of least resistance among pre-existing pores. We show that, in dense environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and organelles. The local compression imposed on the cell body by its surroundings triggers assembly of a central F-actin pool, located between cell front and nucleus. Central actin pushes outward to transiently dilate a path for organelles and nucleus. Pools of central and front actin are tightly coupled and experimental depletion of the central pool enhances actin accumulation and protrusion formation at the cell front. Although this shifted balance speeds up cells in permissive environments, migration in restrictive environments is impaired, as the unleashed leading edge dissociates from the trapped cell body. Our findings establish an actin regulatory loop that balances path dilation with advancement of the leading edge to maintain cellular coherence. acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: This research was supported by the Scientific Service Units of ISTA through resources provided by the Imaging and Optics, Preclinical and Lab Support Facilities. In particular, we thank M. A. Symth and F. G. G. Leite, from the Virus Service Team, who helped generating the lentiviral particles used in this study. We thank all the members of the Sixt group for valuable discussions and feedback, in particular, I. Mayer, for helping with T cell isolation and Z. (P.) Li for providing the Actin–GFP DC line. We are also thankful to J. Mandl and C. Shen for their feedback during the writing of this manuscript. This work was supported by a European Research Council grant ERC-SyG 101071793 to M.S. M.J.A. was supported by an HFSP Postdoctoral Fellowship LTF 177 2021 and A.J.G. by a Lise Meitner Fellowship of the FWF (Austrian Science Fund). Y.F. was supported by the AMED-CREST (JP19gm1310005), the Medical Research Center Initiative for High Depth Omics and CURE:JPMXP1323015486 for MIB, Kyushu University. Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: letter_note author: - first_name: Patricia full_name: Dos Reis Rodrigues, Patricia id: 26E95904-5160-11E9-9C0B-C5B0DC97E90F last_name: Dos Reis Rodrigues orcid: 0000-0003-1681-508X - first_name: Mario full_name: Avellaneda Sarrió, Mario id: DC4BA84C-56E6-11EA-AD5D-348C3DDC885E last_name: Avellaneda Sarrió orcid: 0000-0001-6406-524X - first_name: Nikola full_name: Canigova, Nikola id: 3795523E-F248-11E8-B48F-1D18A9856A87 last_name: Canigova orcid: 0000-0002-8518-5926 - first_name: Florian R full_name: Gärtner, Florian R id: 397A88EE-F248-11E8-B48F-1D18A9856A87 last_name: Gärtner orcid: 0000-0001-6120-3723 - first_name: Kari full_name: Vaahtomeri, Kari id: 368EE576-F248-11E8-B48F-1D18A9856A87 last_name: Vaahtomeri orcid: 0000-0001-7829-3518 - first_name: Michael full_name: Riedl, Michael id: 3BE60946-F248-11E8-B48F-1D18A9856A87 last_name: Riedl orcid: 0000-0003-4844-6311 - first_name: Ingrid full_name: De Vries, Ingrid id: 4C7D837E-F248-11E8-B48F-1D18A9856A87 last_name: De Vries - first_name: Jack full_name: Merrin, Jack id: 4515C308-F248-11E8-B48F-1D18A9856A87 last_name: Merrin orcid: 0000-0001-5145-4609 - first_name: Robert full_name: Hauschild, Robert id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87 last_name: Hauschild orcid: 0000-0001-9843-3522 - first_name: Yoshinori full_name: Fukui, Yoshinori last_name: Fukui - first_name: Alba full_name: Juanes Garcia, Alba id: 40F05888-F248-11E8-B48F-1D18A9856A87 last_name: Juanes Garcia orcid: 0000-0002-1009-9652 - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 citation: ama: Dos Reis Rodrigues P, Avellaneda Sarrió M, Canigova N, et al. Migrating immune cells globally coordinate protrusive forces. Nature Immunology. 2025;26:1258–1266. doi:10.1038/s41590-025-02211-w apa: Dos Reis Rodrigues, P., Avellaneda Sarrió, M., Canigova, N., Gärtner, F. R., Vaahtomeri, K., Riedl, M., … Sixt, M. K. (2025). Migrating immune cells globally coordinate protrusive forces. Nature Immunology. Springer Nature. https://doi.org/10.1038/s41590-025-02211-w chicago: Dos Reis Rodrigues, Patricia, Mario Avellaneda Sarrió, Nikola Canigova, Florian R Gärtner, Kari Vaahtomeri, Michael Riedl, Ingrid de Vries, et al. “Migrating Immune Cells Globally Coordinate Protrusive Forces.” Nature Immunology. Springer Nature, 2025. https://doi.org/10.1038/s41590-025-02211-w. ieee: P. Dos Reis Rodrigues et al., “Migrating immune cells globally coordinate protrusive forces,” Nature Immunology, vol. 26. Springer Nature, pp. 1258–1266, 2025. ista: Dos Reis Rodrigues P, Avellaneda Sarrió M, Canigova N, Gärtner FR, Vaahtomeri K, Riedl M, de Vries I, Merrin J, Hauschild R, Fukui Y, Juanes Garcia A, Sixt MK. 2025. Migrating immune cells globally coordinate protrusive forces. Nature Immunology. 26, 1258–1266. mla: Dos Reis Rodrigues, Patricia, et al. “Migrating Immune Cells Globally Coordinate Protrusive Forces.” Nature Immunology, vol. 26, Springer Nature, 2025, pp. 1258–1266, doi:10.1038/s41590-025-02211-w. short: P. Dos Reis Rodrigues, M. Avellaneda Sarrió, N. Canigova, F.R. Gärtner, K. Vaahtomeri, M. Riedl, I. de Vries, J. Merrin, R. Hauschild, Y. Fukui, A. Juanes Garcia, M.K. Sixt, Nature Immunology 26 (2025) 1258–1266. corr_author: '1' date_created: 2025-07-27T22:01:26Z date_published: 2025-08-01T00:00:00Z date_updated: 2026-04-28T13:26:50Z day: '01' ddc: - '570' department: - _id: MiSi - _id: NanoFab - _id: Bio doi: 10.1038/s41590-025-02211-w external_id: isi: - '001529134300001' pmid: - '40664976' file: - access_level: open_access checksum: 0c725123dca7797c682609bff2c4c5ac content_type: application/pdf creator: dernst date_created: 2025-07-31T08:00:33Z date_updated: 2025-07-31T08:00:33Z file_id: '20096' file_name: 2025_NatureImmunology_ReisRodrigues.pdf file_size: 13514646 relation: main_file success: 1 file_date_updated: 2025-07-31T08:00:33Z has_accepted_license: '1' intvolume: ' 26' isi: 1 language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: 1258–1266 pmid: 1 project: - _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd grant_number: '101071793' name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces' - _id: c092d618-5a5b-11eb-8a69-f92e1e843fc8 grant_number: 944-2020 name: 'Bioelectric patrolling: the role of the local membrane potential in immune cell migration' publication: Nature Immunology publication_identifier: eissn: - 1529-2916 issn: - 1529-2908 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/bench-pressing-cells/ record: - id: '20149' relation: dissertation_contains status: public scopus_import: '1' status: public title: Migrating immune cells globally coordinate protrusive forces tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 26 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '19856' abstract: - lang: eng text: Unlike in crystals, it is difficult to trace emergent material properties of amorphous solids to their underlying structure. Nevertheless, one can tune features of a disordered spring network, ranging from bulk elastic constants to specific allosteric responses, through highly precise alterations of the structure. This has been understood through the notion of independent bond-level response—the observation that, in many cases, different springs have different effects on different properties. While this idea has motivated inverse design in numerous contexts, it has not been formalized and quantified in a general context that not just informs but enables and predicts inverse design. Here, we show how to quantify independent response by linearizing the simultaneous change in multiple emergent features, and introduce the much stronger notion of fully independent response. Remarkably, we find that the mechanical properties of disordered solids are always fully independent across a wide array of scenarios, regardless of the target features, tunable parameters, system size, dimensionality, and class of interactions. Furthermore, our formulation quantifies the susceptibility of features to parameter changes, which is correlated with the maximum linear tunability. We also demonstrate the implications for multifeature inverse design beyond the linear regime. These results formalize our understanding of a key fundamental difference between ordered and disordered solids while also creating a practical tool to both understand and perform inverse design. acknowledgement: We gratefully acknowledge Edouard Hannezo for helpful comments on the manuscript. The work was funded by the Institute of Science and Technology Austria. article_number: '238201' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Mengjie full_name: Zu, Mengjie id: 26dd9e7c-e86a-11eb-a854-82ac731c9ae2 last_name: Zu - first_name: Aayush A full_name: Desai, Aayush A id: 502cfd30-32c1-11ee-a9a4-d8dad5c6739e last_name: Desai - first_name: Carl Peter full_name: Goodrich, Carl Peter id: EB352CD2-F68A-11E9-89C5-A432E6697425 last_name: Goodrich orcid: 0000-0002-1307-5074 citation: ama: Zu M, Desai AA, Goodrich CP. Fully independent response in disordered solids. Physical Review Letters. 2025;134(23). doi:10.1103/PhysRevLett.134.238201 apa: Zu, M., Desai, A. A., & Goodrich, C. P. (2025). Fully independent response in disordered solids. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.134.238201 chicago: Zu, Mengjie, Aayush A Desai, and Carl Peter Goodrich. “Fully Independent Response in Disordered Solids.” Physical Review Letters. American Physical Society, 2025. https://doi.org/10.1103/PhysRevLett.134.238201. ieee: M. Zu, A. A. Desai, and C. P. Goodrich, “Fully independent response in disordered solids,” Physical Review Letters, vol. 134, no. 23. American Physical Society, 2025. ista: Zu M, Desai AA, Goodrich CP. 2025. Fully independent response in disordered solids. Physical Review Letters. 134(23), 238201. mla: Zu, Mengjie, et al. “Fully Independent Response in Disordered Solids.” Physical Review Letters, vol. 134, no. 23, 238201, American Physical Society, 2025, doi:10.1103/PhysRevLett.134.238201. short: M. Zu, A.A. Desai, C.P. Goodrich, Physical Review Letters 134 (2025). corr_author: '1' date_created: 2025-06-22T22:02:06Z date_published: 2025-06-13T00:00:00Z date_updated: 2026-04-28T13:28:02Z day: '13' ddc: - '530' department: - _id: CaGo - _id: IlCa doi: 10.1103/PhysRevLett.134.238201 external_id: arxiv: - '2412.05031' isi: - '001509005900006' file: - access_level: open_access checksum: 040b6779c91aac62c15a9b2cc417b360 content_type: application/pdf creator: dernst date_created: 2025-06-23T11:41:08Z date_updated: 2025-06-23T11:41:08Z file_id: '19874' file_name: 2025_PhysReviewLetters_Zu.pdf file_size: 1132625 relation: main_file success: 1 file_date_updated: 2025-06-23T11:41:08Z has_accepted_license: '1' intvolume: ' 134' isi: 1 issue: '23' language: - iso: eng month: '06' oa: 1 oa_version: Published Version publication: Physical Review Letters publication_identifier: eissn: - 1079-7114 issn: - 0031-9007 publication_status: published publisher: American Physical Society quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/infinite-diversity-in-infinite-combinations/ scopus_import: '1' status: public title: Fully independent response in disordered solids tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 134 year: '2025' ... --- OA_place: publisher _id: '20149' abstract: - lang: eng text: "Immune responses depend on the coordinated and efficient migration of leukocytes. These\r\ncells, which are embedded and tightly confined within tissues, must navigate and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical characteristics of their\r\nsurroundings. In low-density environments, where the pore size of the interstitial matrix\r\nallows free passage, these cells position the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure that forms the leading front of the cell. In this configuration, they\r\nuse the nucleus as a gauge to identify the path of least resistance.\r\nHere, we show that in high-density environments, where the pore size precludes free passage\r\nof the cell body, leukocytes reposition the microtubule-organizing center (MTOC) and\r\nassociated organelles in front of the nucleus. In this configuration, they use actin structures\r\nprotruding orthogonally to the direction of migration in order to open a path for the cell body.\r\nWe identify two distinct actin populations that serve this purpose at different subcellular\r\nlocalizations. At the leading edge, local indentation of the plasma membrane leads to\r\nrecruitment of the Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe formation of individual actin foci. At the cell body, actin polymerization is triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of a central actin pool.\r\nWe demonstrate that the central and peripheral actin pools are functionally communicating\r\nand that depletion of the central actin pool leads to increased actin accumulation at the cell\r\nfront, resulting in excessive extension of the leading edge." acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: M-Shop - _id: NanoFab acknowledgement: "I would like to acknowledge the\r\nfinancial support of the European Research Council through the ERC-SyG grant “Pushing from\r\nwithin: Control of cell shape, integrity and motility by cytoskeletal pushing forces”\r\n(01071793), which made this research possible. " alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Patricia full_name: Dos Reis Rodrigues, Patricia id: 26E95904-5160-11E9-9C0B-C5B0DC97E90F last_name: Dos Reis Rodrigues orcid: 0000-0003-1681-508X citation: ama: Dos Reis Rodrigues P. Coordination of protrusive forces in immune cell migration . 2025. doi:10.15479/AT-ISTA-20149 apa: Dos Reis Rodrigues, P. (2025). Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20149 chicago: Dos Reis Rodrigues, Patricia. “Coordination of Protrusive Forces in Immune Cell Migration .” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20149. ieee: P. Dos Reis Rodrigues, “Coordination of protrusive forces in immune cell migration ,” Institute of Science and Technology Austria, 2025. ista: Dos Reis Rodrigues P. 2025. Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria. mla: Dos Reis Rodrigues, Patricia. Coordination of Protrusive Forces in Immune Cell Migration . Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20149. short: P. Dos Reis Rodrigues, Coordination of Protrusive Forces in Immune Cell Migration , Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-08-08T09:18:02Z date_published: 2025-08-08T00:00:00Z date_updated: 2026-04-28T13:26:50Z day: '08' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: MiSi doi: 10.15479/AT-ISTA-20149 file: - access_level: open_access checksum: fda8a1070667c3562263f4867609b41b content_type: application/pdf creator: prodrigu date_created: 2025-08-27T12:59:10Z date_updated: 2025-08-27T12:59:10Z file_id: '20232' file_name: 2025_ReisRodrigues_Patricia_Thesis.pdf file_size: 63885565 relation: main_file success: 1 - access_level: closed checksum: e8b65affcbce846a926454df4b2867b9 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: prodrigu date_created: 2025-08-27T13:00:30Z date_updated: 2025-08-27T13:02:28Z file_id: '20233' file_name: 2025_ReisRodrigues_Patricia_Thesis.docx file_size: 50483434 relation: source_file file_date_updated: 2025-08-27T13:02:28Z has_accepted_license: '1' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: '114' project: - _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd grant_number: '101071793' name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '10703' relation: part_of_dissertation status: public - id: '20082' relation: part_of_dissertation status: public status: public supervisor: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 title: 'Coordination of protrusive forces in immune cell migration ' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: repository OA_type: gold _id: '18697' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules but dense, synapse-level circuit reconstruction by light microscopy has been out of reach due to limitations in resolution, contrast, and volumetric imaging capability. Here we developed light-microscopy based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning based segmentation and analysis of connectivity, thus directly incorporating molecular information in synapse-level brain tissue reconstructions. LICONN will allow synapse-level brain tissue phenotyping in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: E-Lib article_processing_charge: No author: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger citation: ama: Danzl JG, Lyudchik J, Kreuzinger C. Light-microscopy based connectomic reconstruction of mammalian brain tissue. 2025. doi:10.15479/AT:ISTA:18697 apa: Danzl, J. G., Lyudchik, J., & Kreuzinger, C. (2025). Light-microscopy based connectomic reconstruction of mammalian brain tissue. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:18697 chicago: Danzl, Johann G, Julia Lyudchik, and Caroline Kreuzinger. “Light-Microscopy Based Connectomic Reconstruction of Mammalian Brain Tissue.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT:ISTA:18697. ieee: J. G. Danzl, J. Lyudchik, and C. Kreuzinger, “Light-microscopy based connectomic reconstruction of mammalian brain tissue.” Institute of Science and Technology Austria, 2025. ista: Danzl JG, Lyudchik J, Kreuzinger C. 2025. Light-microscopy based connectomic reconstruction of mammalian brain tissue, Institute of Science and Technology Austria, 10.15479/AT:ISTA:18697. mla: Danzl, Johann G., et al. Light-Microscopy Based Connectomic Reconstruction of Mammalian Brain Tissue. Institute of Science and Technology Austria, 2025, doi:10.15479/AT:ISTA:18697. short: J.G. Danzl, J. Lyudchik, C. Kreuzinger, (2025). contributor: - contributor_type: researcher first_name: Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - contributor_type: researcher first_name: Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - contributor_type: researcher first_name: Michal last_name: Januszewski - contributor_type: researcher first_name: Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - contributor_type: researcher first_name: Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - contributor_type: researcher first_name: Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer - contributor_type: researcher first_name: Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - contributor_type: researcher first_name: Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - contributor_type: researcher first_name: Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - contributor_type: researcher first_name: Alban last_name: Cenameri - contributor_type: researcher first_name: Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - contributor_type: researcher first_name: Viren last_name: Jain - contributor_type: researcher first_name: Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 corr_author: '1' date_created: 2024-12-20T09:22:20Z date_published: 2025-03-03T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '03' ddc: - '570' department: - _id: JoDa doi: 10.15479/AT:ISTA:18697 file: - access_level: open_access checksum: d2c3efcd354f967290f91ff34dfb3cc1 content_type: text/rtf creator: jdanzl date_created: 2025-02-28T16:50:39Z date_updated: 2025-02-28T16:50:39Z file_id: '19275' file_name: Readme_Data_Tavakoli_et_al_2025.rtf file_size: 1922 relation: main_file success: 1 - access_level: open_access checksum: b20cfb9b7030375f94d4b9bc5ce5cee9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19089' file_name: Fig1b (1).tif file_size: 69884200 relation: main_file success: 1 - 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access_level: open_access checksum: 032c7c52f36298252cc0b19b83ea0648 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:49:50Z date_updated: 2025-02-27T12:49:50Z file_id: '19266' file_name: SF24 (1).tif file_size: 121784120 relation: main_file success: 1 - access_level: open_access checksum: 5867b6b999d0c3d91354d92ba0d6c30b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:49:50Z date_updated: 2025-02-27T12:49:50Z file_id: '19267' file_name: SF24 (2).tif file_size: 121784062 relation: main_file success: 1 - access_level: open_access checksum: bbf1267c8030894e846f2dc95a955014 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:51:29Z date_updated: 2025-02-27T12:51:29Z file_id: '19268' file_name: SF25.tif file_size: 2995439929 relation: main_file success: 1 - access_level: open_access checksum: 3db644adb7181eef3181e1c418856741 content_type: image/tiff creator: ckreuzin date_created: 2025-02-28T09:07:23Z date_updated: 2025-02-28T09:07:23Z file_id: '19269' file_name: LICONN_gephyrin_test.tif file_size: 2400199306 relation: main_file success: 1 - access_level: open_access checksum: 0d716ad1249be4de51e79b6d832340b9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-28T09:15:48Z date_updated: 2025-02-28T09:15:48Z file_id: '19270' file_name: LICONN_test_dataset.tif file_size: 588107137 relation: main_file success: 1 file_date_updated: 2025-02-28T16:50:39Z has_accepted_license: '1' month: '03' oa: 1 oa_version: Published Version publisher: Institute of Science and Technology Austria related_material: link: - description: Original datasets of large size (>10GB) and datasets in zarr/n5/ims/npz format are provided via this external link. relation: research_data url: https://pub.ista.ac.at/group_danzl/data/LICONN/ record: - id: '19704' relation: used_in_publication status: public status: public title: Light-microscopy based connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19704' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of reach, owing to limitations in resolution, contrast and volumetric imaging capability. Here we describe light-microscopy-based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning-based segmentation and analysis of connectivity, thereby directly incorporating molecular information into synapse-level reconstructions of brain tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: E-Lib acknowledgement: 'We thank S. Dorkenwald and P. Li for critical reading of the manuscript, S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open access funding provided by Institute of Science and Technology (IST Austria).' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Michał full_name: Januszewski, Michał last_name: Januszewski - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Bárbara full_name: Oliveira, Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Viren full_name: Jain, Viren last_name: Jain - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 2025;642:398-410. doi:10.1038/s41586-025-08985-1 apa: Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08985-1 chicago: Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08985-1. ieee: M. Tavakoli et al., “Light-microscopy-based connectomic reconstruction of mammalian brain tissue,” Nature, vol. 642. Springer Nature, pp. 398–410, 2025. ista: Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 642, 398–410. mla: Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature, vol. 642, Springer Nature, 2025, pp. 398–410, doi:10.1038/s41586-025-08985-1. short: M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, Nature 642 (2025) 398–410. corr_author: '1' date_created: 2025-05-18T22:02:51Z date_published: 2025-06-12T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '12' ddc: - '570' department: - _id: JoDa - _id: GradSch - _id: Bio - _id: GaNo doi: 10.1038/s41586-025-08985-1 ec_funded: 1 external_id: isi: - '001483477000001' pmid: - '40335689' file: - access_level: open_access checksum: ebc99d7108e728f46db0a009292675ef content_type: application/pdf creator: dernst date_created: 2025-07-03T06:55:20Z date_updated: 2025-07-03T06:55:20Z file_id: '19959' file_name: 2025_Nature_Tavakoli.pdf file_size: 133201290 relation: main_file success: 1 file_date_updated: 2025-07-03T06:55:20Z has_accepted_license: '1' intvolume: ' 642' isi: 1 language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: 398-410 pmid: 1 project: - _id: 6285a163-2b32-11ec-9570-8e204ca2dba5 grant_number: '26137' name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6 grant_number: '101044865' name: Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/piecing-together-the-brain-puzzle/ record: - id: '18677' relation: earlier_version status: public - id: '18697' relation: research_data status: public scopus_import: '1' status: public title: Light-microscopy-based connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 642 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19602' abstract: - lang: eng text: N4-methylcytosine (4mC) is an important DNA modification in prokaryotes, but its relevance and even its presence in eukaryotes have been mysterious. Here we show that spermatogenesis in the liverwort Marchantia polymorpha involves two waves of extensive DNA methylation reprogramming. First, 5-methylcytosine (5mC) expands from transposons to the entire genome. Notably, the second wave installs 4mC throughout genic regions, covering over 50% of CG sites in sperm. 4mC requires a methyltransferase (MpDN4MT1a) that is specifically expressed during late spermiogenesis. Deletion of MpDN4MT1a alters the sperm transcriptome, causes sperm swimming and fertility defects, and impairs post-fertilization development. Our results reveal extensive 4mC in a eukaryote, identify a family of eukaryotic methyltransferases, and elucidate the biological functions of 4mC in reproductive development, thereby expanding the repertoire of functional eukaryotic DNA modifications. acknowledged_ssus: - _id: Bio - _id: ScienComp acknowledgement: We thank Sir Richard Roberts (NEB) for the kind gift of anti-4mC antibodies. We are also grateful to the JIC Small Molecule Mass Spectrometry (Lionel Hill) and Chemistry (Martin Rejzek) platforms as well as the High Resolution Metabolomics Laboratory (Manfred Beckmann, Aberystwyth University) for their assistance with LC-MS. Additionally, we acknowledge the assistance of the JIC Bioimaging Facility and ISTA Imaging and Optics Facility for microscopy. Finally, we appreciate the High Performance Computing resources provided by the ISTA Scientific Computing Facility and Norwich BioScience Institute Partnership Computing Infrastructure. This work was funded by a Sainsbury Charitable Foundation studentship (J.W.), a UKRI-BBSRC Doctoral Training Partnerships studentship (BBT0087171 to J.T.), a European Research Council Starting Grant (“SexMeth” 804981 to J.W., S.X., and X.F.), two Biotechnology and Biological Sciences Research Council (BBSRC) grants (BBS0096201 and BBP0135111 to J.Z., M.V., and X.F.), an EMBO Long Term Fellowship (Y.L.), an ISTA Bridge Fellowship (S.X.), and ISTA core funding (Y.Y. and X.F.). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: James full_name: Walker, James last_name: Walker - first_name: Jingyi full_name: Zhang, Jingyi last_name: Zhang - first_name: Yalin full_name: Liu, Yalin last_name: Liu - first_name: Shujuan full_name: Xu, Shujuan id: 9724dd9d-f591-11ee-bd51-e97ed0652286 last_name: Xu - first_name: Yiming full_name: Yu, Yiming id: 318e643b-8b61-11ed-b69e-aafa103ec8dd last_name: Yu orcid: 0000-0002-9919-7282 - first_name: Martin full_name: Vickers, Martin last_name: Vickers - first_name: Weizhi full_name: Ouyang, Weizhi id: fec73395-8b60-11ed-b69e-927fda99c743 last_name: Ouyang - first_name: Judit full_name: Tálas, Judit last_name: Tálas - first_name: Liam full_name: Dolan, Liam last_name: Dolan - first_name: Keiji full_name: Nakajima, Keiji last_name: Nakajima - first_name: Xiaoqi full_name: Feng, Xiaoqi id: e0164712-22ee-11ed-b12a-d80fcdf35958 last_name: Feng orcid: 0000-0002-4008-1234 citation: ama: Walker J, Zhang J, Liu Y, et al. Extensive N4 cytosine methylation is essential for Marchantia sperm function. Cell. 2025;188(11):2890-2906.e14. doi:10.1016/j.cell.2025.03.014 apa: Walker, J., Zhang, J., Liu, Y., Xu, S., Yu, Y., Vickers, M., … Feng, X. (2025). Extensive N4 cytosine methylation is essential for Marchantia sperm function. Cell. Elsevier. https://doi.org/10.1016/j.cell.2025.03.014 chicago: Walker, James, Jingyi Zhang, Yalin Liu, Shujuan Xu, Yiming Yu, Martin Vickers, Weizhi Ouyang, et al. “Extensive N4 Cytosine Methylation Is Essential for Marchantia Sperm Function.” Cell. Elsevier, 2025. https://doi.org/10.1016/j.cell.2025.03.014. ieee: J. Walker et al., “Extensive N4 cytosine methylation is essential for Marchantia sperm function,” Cell, vol. 188, no. 11. Elsevier, p. 2890–2906.e14, 2025. ista: Walker J, Zhang J, Liu Y, Xu S, Yu Y, Vickers M, Ouyang W, Tálas J, Dolan L, Nakajima K, Feng X. 2025. Extensive N4 cytosine methylation is essential for Marchantia sperm function. Cell. 188(11), 2890–2906.e14. mla: Walker, James, et al. “Extensive N4 Cytosine Methylation Is Essential for Marchantia Sperm Function.” Cell, vol. 188, no. 11, Elsevier, 2025, p. 2890–2906.e14, doi:10.1016/j.cell.2025.03.014. short: J. Walker, J. Zhang, Y. Liu, S. Xu, Y. Yu, M. Vickers, W. Ouyang, J. Tálas, L. Dolan, K. Nakajima, X. Feng, Cell 188 (2025) 2890–2906.e14. corr_author: '1' date_created: 2025-04-20T22:01:28Z date_published: 2025-05-29T00:00:00Z date_updated: 2026-04-28T13:36:51Z day: '29' ddc: - '570' department: - _id: XiFe doi: 10.1016/j.cell.2025.03.014 ec_funded: 1 external_id: isi: - '001504744800006' pmid: - '40209706' file: - access_level: open_access checksum: 0dcc2feb368dfe7c4890093366b2dacb content_type: application/pdf creator: dernst date_created: 2025-12-29T13:40:32Z date_updated: 2025-12-29T13:40:32Z file_id: '20871' file_name: 2025_Cell_Walker.pdf file_size: 11622960 relation: main_file success: 1 file_date_updated: 2025-12-29T13:40:32Z has_accepted_license: '1' intvolume: ' 188' isi: 1 issue: '11' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: 2890-2906.e14 pmid: 1 project: - _id: bdb51a6e-d553-11ed-ba76-c2025f3d5725 call_identifier: H2020 grant_number: '804981' name: Establishment, modulation and inheritance of sexual lineage specific DNA methylation in plants publication: Cell publication_identifier: eissn: - 1097-4172 issn: - 0092-8674 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/from-bacterial-immunity-to-plant-sex/ scopus_import: '1' status: public title: Extensive N4 cytosine methylation is essential for Marchantia sperm function tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 188 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '19664' abstract: - lang: eng text: Persistent revivals recently observed in Rydberg atom simulators have challenged our understanding of thermalization and attracted much interest to the concept of quantum many-body scars (QMBSs). QMBSs are non-thermal highly excited eigenstates that coexist with typical eigenstates in the spectrum of many-body Hamiltonians, and have since been reported in multiple theoretical models, including the so-called PXP model, approximately realized by Rydberg simulators. At the same time, questions of how common QMBSs are and in what models they are physically realized remain open. In this Letter, we demonstrate that QMBSs exist in a broader family of models that includes and generalizes PXP to longer-range constraints and states with different periodicity. We show that in each model, multiple QMBS families can be found. Each of them relies on a different approximate algebra, leading to oscillatory dynamics in all cases. However, in contrast to the PXP model, their observation requires launching dynamics from weakly entangled initial states rather than from a product state. QMBSs reported here may be experimentally probed using Rydberg atom simulator in the regime of longer-range Rydberg blockades. acknowledgement: The authors are grateful to Zlatko Papić, Dolev Bluvstein, Nishad Maskara, Marcello Dalmonte, Thomas Iadecola, and Johannes Feldmeier for insightful discussions. A. K., M. L., and M. S. acknowledge support by the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899). J.-Y. D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413. article_number: '160401' article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Aron full_name: Kerschbaumer, Aron id: ade85a9c-3200-11ee-973b-91c1eb240410 last_name: Kerschbaumer orcid: 0009-0002-2370-8661 - first_name: Marko full_name: Ljubotina, Marko id: F75EE9BE-5C90-11EA-905D-16643DDC885E last_name: Ljubotina orcid: 0000-0003-0038-7068 - first_name: Maksym full_name: Serbyn, Maksym id: 47809E7E-F248-11E8-B48F-1D18A9856A87 last_name: Serbyn orcid: 0000-0002-2399-5827 - first_name: Jean-Yves Marc full_name: Desaules, Jean-Yves Marc id: 6c292945-a610-11ed-9eec-c3be1ad62a80 last_name: Desaules orcid: 0000-0002-3749-6375 citation: ama: Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. 2025;134(16). doi:10.1103/PhysRevLett.134.160401 apa: Kerschbaumer, A., Ljubotina, M., Serbyn, M., & Desaules, J.-Y. M. (2025). Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.134.160401 chicago: Kerschbaumer, Aron, Marko Ljubotina, Maksym Serbyn, and Jean-Yves Marc Desaules. “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Physical Review Letters. American Physical Society, 2025. https://doi.org/10.1103/PhysRevLett.134.160401. ieee: A. Kerschbaumer, M. Ljubotina, M. Serbyn, and J.-Y. M. Desaules, “Quantum many-body scars beyond the PXP model in Rydberg simulators,” Physical Review Letters, vol. 134, no. 16. American Physical Society, 2025. ista: Kerschbaumer A, Ljubotina M, Serbyn M, Desaules J-YM. 2025. Quantum many-body scars beyond the PXP model in Rydberg simulators. Physical Review Letters. 134(16), 160401. mla: Kerschbaumer, Aron, et al. “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Physical Review Letters, vol. 134, no. 16, 160401, American Physical Society, 2025, doi:10.1103/PhysRevLett.134.160401. short: A. Kerschbaumer, M. Ljubotina, M. Serbyn, J.-Y.M. Desaules, Physical Review Letters 134 (2025). date_created: 2025-05-11T22:02:38Z date_published: 2025-04-22T00:00:00Z date_updated: 2026-04-28T13:34:57Z day: '22' ddc: - '530' department: - _id: MaSe doi: 10.1103/PhysRevLett.134.160401 ec_funded: 1 external_id: arxiv: - '2410.18913' isi: - '001480669300011' pmid: - '40344113' file: - access_level: open_access checksum: b7f581291e20f152d0efc64727314ca2 content_type: application/pdf creator: dernst date_created: 2025-05-12T07:33:38Z date_updated: 2025-05-12T07:33:38Z file_id: '19677' file_name: 2025_PhysReviewLetters_Kerschbaumer.pdf file_size: 1028993 relation: main_file success: 1 file_date_updated: 2025-05-12T07:33:38Z has_accepted_license: '1' intvolume: ' 134' isi: 1 issue: '16' language: - iso: eng month: '04' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 23841C26-32DE-11EA-91FC-C7463DDC885E call_identifier: H2020 grant_number: '850899' name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control' - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: Physical Review Letters publication_identifier: eissn: - 1079-7114 issn: - 0031-9007 publication_status: published publisher: American Physical Society quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/a-sky-full-of-quantum-scars/ record: - id: '19623' relation: research_data status: public scopus_import: '1' status: public title: Quantum many-body scars beyond the PXP model in Rydberg simulators tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 134 year: '2025' ... --- _id: '19623' abstract: - lang: eng text: "Persistent revivals recently observed in Rydberg atom simulators have challenged our understanding of thermalization and attracted much interest to the concept of quantum many-body scars (QMBSs). QMBSs are non-thermal highly excited eigenstates that coexist with typical eigenstates in the spectrum of many-body Hamiltonians, and have since been reported in multiple theoretical models, including the so-called PXP model, approximately realized by Rydberg simulators. At the same time, questions of how common QMBSs are and in what models they are physically realized remain open. In this Letter, we demonstrate that QMBSs exist in a broader family of models that includes and generalizes PXP to longer-range constraints and states with different periodicity. We show that in each model, multiple QMBS families can be found. Each of them relies on a different approximate \U0001D530\U0001D532⁡(2) algebra, leading to oscillatory dynamics in all cases. However, in contrast to the PXP model, their observation requires launching dynamics from weakly entangled initial states rather than from a product state. QMBSs reported here may be experimentally probed using Rydberg atom simulator in the regime of longer-range Rydberg blockades." acknowledged_ssus: - _id: ScienComp acknowledgement: The authors are grateful to Zlatko Papić, Dolev Bluvstein, Nishad Maskara, Marcello Dalmonte, Thomas Iadecola, and Johannes Feldmeier for insightful discussions. A. K., M. L., and M. S. acknowledge support by the European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899). J.-Y. D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 101034413. article_processing_charge: No author: - first_name: Jean-Yves Marc full_name: Desaules, Jean-Yves Marc id: 6c292945-a610-11ed-9eec-c3be1ad62a80 last_name: Desaules orcid: 0000-0002-3749-6375 citation: ama: Desaules J-YM. Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” 2025. doi:10.15479/AT:ISTA:19623 apa: Desaules, J.-Y. M. (2025). Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:19623 chicago: Desaules, Jean-Yves Marc. “Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.’” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT:ISTA:19623. ieee: J.-Y. M. Desaules, “Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.’” Institute of Science and Technology Austria, 2025. ista: Desaules J-YM. 2025. Research Data for ‘Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:19623. mla: Desaules, Jean-Yves Marc. Research Data for “Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators.” Institute of Science and Technology Austria, 2025, doi:10.15479/AT:ISTA:19623. short: J.-Y.M. Desaules, (2025). contributor: - contributor_type: researcher first_name: Aron id: ade85a9c-3200-11ee-973b-91c1eb240410 last_name: Kerschbaumer - contributor_type: researcher first_name: Marko last_name: Ljubotina - contributor_type: researcher first_name: Maksym id: 47809E7E-F248-11E8-B48F-1D18A9856A87 last_name: Serbyn orcid: 0000-0002-2399-5827 - contributor_type: researcher first_name: Jean-Yves Marc id: 6c292945-a610-11ed-9eec-c3be1ad62a80 last_name: Desaules orcid: 0000-0002-3749-6375 corr_author: '1' date_created: 2025-04-24T19:58:46Z date_published: 2025-04-24T00:00:00Z date_updated: 2026-04-28T13:34:56Z day: '24' ddc: - '530' department: - _id: MaSe doi: 10.15479/AT:ISTA:19623 ec_funded: 1 file: - access_level: open_access checksum: d073314c4dc95d93feaadbff188ce4a1 content_type: application/zip creator: jdesaule date_created: 2025-05-05T07:14:17Z date_updated: 2025-05-05T07:14:17Z file_id: '19646' file_name: Data+Code.zip file_size: 583478621 relation: main_file success: 1 - access_level: open_access checksum: d386a2364fb1147ef6dad30ad029c080 content_type: text/plain creator: jdesaule date_created: 2025-05-05T07:13:46Z date_updated: 2025-05-05T07:13:46Z file_id: '19647' file_name: readme.txt file_size: 15856 relation: main_file success: 1 file_date_updated: 2025-05-05T07:14:17Z has_accepted_license: '1' keyword: - quantum many-body scars - non-equilibrium physics - Rydberg atoms license: https://creativecommons.org/licenses/by-nc/4.0/ month: '04' oa: 1 oa_version: None project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' - _id: 23841C26-32DE-11EA-91FC-C7463DDC885E call_identifier: H2020 grant_number: '850899' name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control' publisher: Institute of Science and Technology Austria related_material: record: - id: '19664' relation: used_in_publication status: public status: public title: Research Data for "Quantum Many-Body Scars beyond the PXP Model in Rydberg Simulators" tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '19278' abstract: - lang: eng text: 'When two insulating, neutral materials are contacted and separated, they exchange electrical charge1. Experiments have long suggested that this ‘contact electrification’ is transitive, with different materials ordering into ‘triboelectric series’ based on the sign of charge acquired2. At the same time, the effect is plagued by unpredictability, preventing consensus on the mechanism and casting doubt on the rhyme and reason that series imply3. Here we expose an unanticipated connection between the unpredictability and order in contact electrification: nominally identical materials initially exchange charge randomly and intransitively, but—over repeated experiments—order into triboelectric series. We find that this evolution is driven by the act of contact itself—samples with more contacts in their history charge negatively to ones with fewer contacts. Capturing this ‘contact bias’ in a minimal model, we recreate both the initial randomness and ultimate order in numerical simulations and use it experimentally to force the appearance of a triboelectric series of our choosing. With a set of surface-sensitive techniques to search for the underlying alterations contact creates, we only find evidence of nanoscale morphological changes, pointing to a mechanism strongly coupled with mechanics. Our results highlight the centrality of contact history in contact electrification and suggest that focusing on the unpredictability that has long plagued the effect may hold the key to understanding it.' acknowledged_ssus: - _id: M-Shop - _id: NanoFab - _id: ScienComp - _id: EM-Fac - _id: LifeSc acknowledgement: This project has received financing from the European Research Council grant agreement no. 949120 under the European Union’s Horizon 2020 research and innovation programme. The Analytical Instrumentation Center of the TU Wien acknowledges support by the FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility, Electron Microscopy Facility and Lab Support Facility. We thank J. Garcia-Suarez and G. Anciaux for the suggestion to look into the roughness power spectral density. We thank I.-M. Strugaru for help with testing the device for Young’s modulus measurements. Open access funding provided by Institute of Science and Technology (IST Austria). article_number: 664-669 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Juan Carlos A full_name: Sobarzo Ponce, Juan Carlos A id: 4B807D68-AE37-11E9-AC72-31CAE5697425 last_name: Sobarzo Ponce - first_name: Felix full_name: Pertl, Felix id: 6313aec0-15b2-11ec-abd3-ed67d16139af last_name: Pertl orcid: 0000-0003-0463-5794 - first_name: Daniel full_name: Balazs, Daniel id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E last_name: Balazs orcid: 0000-0001-7597-043X - first_name: Tommaso full_name: Costanzo, Tommaso id: D93824F4-D9BA-11E9-BB12-F207E6697425 last_name: Costanzo orcid: 0000-0001-9732-3815 - first_name: Markus full_name: Sauer, Markus last_name: Sauer - first_name: Annette full_name: Foelske, Annette last_name: Foelske - first_name: Markus full_name: Ostermann, Markus last_name: Ostermann - first_name: Christian M. full_name: Pichler, Christian M. last_name: Pichler - first_name: Yongkang full_name: Wang, Yongkang last_name: Wang - first_name: Yuki full_name: Nagata, Yuki last_name: Nagata - first_name: Mischa full_name: Bonn, Mischa last_name: Bonn - first_name: Scott R full_name: Waitukaitis, Scott R id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87 last_name: Waitukaitis orcid: 0000-0002-2299-3176 citation: ama: Sobarzo Ponce JCA, Pertl F, Balazs D, et al. Spontaneous ordering of identical materials into a triboelectric series. Nature. 2025;638(8051). doi:10.1038/s41586-024-08530-6 apa: Sobarzo Ponce, J. C. A., Pertl, F., Balazs, D., Costanzo, T., Sauer, M., Foelske, A., … Waitukaitis, S. R. (2025). Spontaneous ordering of identical materials into a triboelectric series. Nature. Springer Nature. https://doi.org/10.1038/s41586-024-08530-6 chicago: Sobarzo Ponce, Juan Carlos A, Felix Pertl, Daniel Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-024-08530-6. ieee: J. C. A. Sobarzo Ponce et al., “Spontaneous ordering of identical materials into a triboelectric series,” Nature, vol. 638, no. 8051. Springer Nature, 2025. ista: Sobarzo Ponce JCA, Pertl F, Balazs D, Costanzo T, Sauer M, Foelske A, Ostermann M, Pichler CM, Wang Y, Nagata Y, Bonn M, Waitukaitis SR. 2025. Spontaneous ordering of identical materials into a triboelectric series. Nature. 638(8051), 664–669. mla: Sobarzo Ponce, Juan Carlos A., et al. “Spontaneous Ordering of Identical Materials into a Triboelectric Series.” Nature, vol. 638, no. 8051, 664–669, Springer Nature, 2025, doi:10.1038/s41586-024-08530-6. short: J.C.A. Sobarzo Ponce, F. Pertl, D. Balazs, T. Costanzo, M. Sauer, A. Foelske, M. Ostermann, C.M. Pichler, Y. Wang, Y. Nagata, M. Bonn, S.R. Waitukaitis, Nature 638 (2025). corr_author: '1' date_created: 2025-03-02T23:01:52Z date_published: 2025-02-20T00:00:00Z date_updated: 2026-04-28T13:44:56Z day: '20' ddc: - '530' department: - _id: ScWa - _id: LifeSc - _id: EM-Fac doi: 10.1038/s41586-024-08530-6 ec_funded: 1 external_id: isi: - '001428076100015' pmid: - '39972227' file: - access_level: open_access checksum: fecf302274dd3218d3e7dd22f39a6c0c content_type: application/pdf creator: dernst date_created: 2025-03-04T10:05:18Z date_updated: 2025-03-04T10:05:18Z file_id: '19289' file_name: 2025_Nature_Sobarzo.pdf file_size: 3807415 relation: main_file success: 1 file_date_updated: 2025-03-04T10:05:18Z has_accepted_license: '1' intvolume: ' 638' isi: 1 issue: '8051' language: - iso: eng month: '02' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa call_identifier: H2020 grant_number: '949120' name: 'Tribocharge: a multi-scale approach to an enduring problem in physics' publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/an-electrifying-turn-in-an-age-old-quest/ record: - id: '20203' relation: dissertation_contains status: public scopus_import: '1' status: public title: Spontaneous ordering of identical materials into a triboelectric series tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 638 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19421' abstract: - lang: eng text: The phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism. TIR1/AFB auxin receptors are F-box subunits of an ubiquitin ligase complex; after auxin perception, they associate with Aux/IAA transcriptional repressors and ubiquitinate them for degradation, thus enabling the activation of auxin response factor (ARF) transcription factors1,2,3. Here we revise this paradigm by showing that without TIR1 adenylate cyclase (AC) activity4, auxin-induced degradation of Aux/IAAs is not sufficient to mediate the transcriptional auxin response. Abolishing the TIR1 AC activity does not affect auxin-induced degradation of Aux/IAAs but renders TIR1 non-functional in mediating transcriptional reprogramming and auxin-regulated development, including shoot, root, root hair growth and lateral root formation. Transgenic plants show that local cAMP production in the vicinity of the Aux/IAA–ARF complex by unrelated AC enzymes bypasses the need for auxin perception and is sufficient to induce ARF-mediated transcription. These discoveries revise the canonical model of auxin signalling and establish TIR1/AFB-produced cAMP as a second messenger essential for transcriptional reprograming. acknowledged_ssus: - _id: LifeSc - _id: Bio acknowledgement: We are grateful to J. Callis and H.-Q. Yang for sharing materials and to M. Estelle and S. Kepinski for inspiring discussions. This research was supported by the Laboratory Support Facility, the Plant Facility and the Imaging and Optics Facility of the Institute of Science and Technology Austria. This project has received funding from the European Research Council (101142681 CYNIPS) and Austrian Science Fund (P 37051-B). L.Q. was supported by the National Natural Science Foundation of China (grant no. 32470327). M.Z. was supported by the Interdisciplinary Project Committee of the Institute of Science and Technology Austria, and Y.P. was supported by an EMBO Postdoctoral Fellowship (ALTF 38-2023). Open access funding provided by Institute of Science and Technology (IST Austria). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Huihuang full_name: Chen, Huihuang id: 83c96512-15b2-11ec-abd3-b7eede36184f last_name: Chen - first_name: Linlin full_name: Qi, Linlin id: 44B04502-A9ED-11E9-B6FC-583AE6697425 last_name: Qi orcid: 0000-0001-5187-8401 - first_name: Minxia full_name: Zou, Minxia id: 5c243f41-03f3-11ec-841c-96faf48a7ef9 last_name: Zou - first_name: Mengting full_name: Lu, Mengting id: a8198a14-1ffe-11ee-8b67-d2bdff9d9178 last_name: Lu - first_name: M full_name: Kwiatkowski, M last_name: Kwiatkowski - first_name: Yuanrong full_name: Pei, Yuanrong id: 98605edc-6ce7-11ee-95f3-cc16b866efcd last_name: Pei - first_name: K full_name: Jaworski, K last_name: Jaworski - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Chen H, Qi L, Zou M, et al. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. 2025;640:1011-1016. doi:10.1038/s41586-025-08669-w apa: Chen, H., Qi, L., Zou, M., Lu, M., Kwiatkowski, M., Pei, Y., … Friml, J. (2025). TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08669-w chicago: Chen, Huihuang, Linlin Qi, Minxia Zou, Mengting Lu, M Kwiatkowski, Yuanrong Pei, K Jaworski, and Jiří Friml. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08669-w. ieee: H. Chen et al., “TIR1-produced cAMP as a second messenger in transcriptional auxin signalling,” Nature, vol. 640. Springer Nature, pp. 1011–1016, 2025. ista: Chen H, Qi L, Zou M, Lu M, Kwiatkowski M, Pei Y, Jaworski K, Friml J. 2025. TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. Nature. 640, 1011–1016. mla: Chen, Huihuang, et al. “TIR1-Produced CAMP as a Second Messenger in Transcriptional Auxin Signalling.” Nature, vol. 640, Springer Nature, 2025, pp. 1011–16, doi:10.1038/s41586-025-08669-w. short: H. Chen, L. Qi, M. Zou, M. Lu, M. Kwiatkowski, Y. Pei, K. Jaworski, J. Friml, Nature 640 (2025) 1011–1016. corr_author: '1' date_created: 2025-03-19T09:44:39Z date_published: 2025-04-24T00:00:00Z date_updated: 2026-04-28T13:42:45Z day: '24' ddc: - '580' department: - _id: JiFr doi: 10.1038/s41586-025-08669-w external_id: isi: - '001437493900001' pmid: - '40044868' file: - access_level: open_access checksum: f5f18081003e7a1b8e372ecb7da82e7d content_type: application/pdf creator: dernst date_created: 2025-08-05T12:29:35Z date_updated: 2025-08-05T12:29:35Z file_id: '20132' file_name: 2025_Nature_Chen.pdf file_size: 13549245 relation: main_file success: 1 file_date_updated: 2025-08-05T12:29:35Z has_accepted_license: '1' intvolume: ' 640' isi: 1 language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 1011-1016 pmid: 1 project: - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/updating-the-textbook/ record: - id: '19478' relation: dissertation_contains status: public status: public title: TIR1-produced cAMP as a second messenger in transcriptional auxin signalling tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 640 year: '2025' ... --- OA_place: publisher _id: '20203' abstract: - lang: eng text: Tribocharging, or contact electrification, is the phenomenon in which two initially neutral materials exchange electric charge through contact and subsequent separation. While it is widely observed in everyday life and crucial to numerous natural processes, even the most basic aspects of tribocharging are still a mystery—what are the charge carriers involved and what drives their exchange? This work spans three separate projects that address different aspects of tribocharging. First, we introduce a novel strategy combining Finite Element Method (FEM) simulations with Kelvin Probe Force Microscopy (KPFM) to quantitatively extract surface charge density from surface voltage maps. Second, we present a simple theoretical model that allows for the existence of triboelectric cycles, under the assumption that multiple charge carrying species are involved. Third, we present experimental evidence that identical materials can spontaneously evolve into a triboelectric series, driven by contact history. Modeling this behavior enables the replication of experimental results with simulations, and even experimentally forcing the appearance of a pre-designed series by manipulating contact history. Together, the findings from these projects challenge traditional views on tribocharging, provide new tools for probing it, and open up new avenues of research—all with the hopes of bringing us closer to understanding this puzzling phenomenon. acknowledged_ssus: - _id: M-Shop - _id: NanoFab - _id: EM-Fac - _id: LifeSc - _id: ScienComp acknowledgement: "The project in Chapter 2 has received funding from the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation programme (Grant Agreement\r\nNo. 949120).\r\nThe project in Chapter 3 has received funding from the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation programme (Grant Agreement\r\nNo. 949120).\r\nThe project in Chapter 4 has received financing from the European Research Council grant\r\nagreement No. 949120 under the European Union’s Horizon 2020 research and innovation\r\nprogramme. The Analytical Instrumentation Center of the TU Wien acknowledges support by\r\nthe FFG project ‘ELSA’ under grant no. 884672. C.M.P. and M.O. acknowledge the state\r\nof Lower Austria and the European Regional Development Fund under grant no. WST3-F542638/004-2021.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Juan Carlos A full_name: Sobarzo Ponce, Juan Carlos A id: 4B807D68-AE37-11E9-AC72-31CAE5697425 last_name: Sobarzo Ponce citation: ama: 'Sobarzo Ponce JCA. Tribocharging of identical insulators : Triboelectric series, triboelectric cycles and surface charges. 2025. doi:10.15479/AT-ISTA-20203' apa: 'Sobarzo Ponce, J. C. A. (2025). Tribocharging of identical insulators : Triboelectric series, triboelectric cycles and surface charges. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20203' chicago: 'Sobarzo Ponce, Juan Carlos A. “Tribocharging of Identical Insulators : Triboelectric Series, Triboelectric Cycles and Surface Charges.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20203.' ieee: 'J. C. A. Sobarzo Ponce, “Tribocharging of identical insulators : Triboelectric series, triboelectric cycles and surface charges,” Institute of Science and Technology Austria, 2025.' ista: 'Sobarzo Ponce JCA. 2025. Tribocharging of identical insulators : Triboelectric series, triboelectric cycles and surface charges. Institute of Science and Technology Austria.' mla: 'Sobarzo Ponce, Juan Carlos A. Tribocharging of Identical Insulators : Triboelectric Series, Triboelectric Cycles and Surface Charges. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20203.' short: 'J.C.A. Sobarzo Ponce, Tribocharging of Identical Insulators : Triboelectric Series, Triboelectric Cycles and Surface Charges, Institute of Science and Technology Austria, 2025.' corr_author: '1' date_created: 2025-08-21T11:42:59Z date_published: 2025-08-27T00:00:00Z date_updated: 2026-04-28T13:44:56Z day: '27' ddc: - '530' degree_awarded: PhD department: - _id: GradSch - _id: ScWa doi: 10.15479/AT-ISTA-20203 ec_funded: 1 file: - access_level: open_access checksum: 661b9d3786cfc985be811befc3262bf5 content_type: application/pdf creator: jsobarzo date_created: 2025-08-27T14:50:32Z date_updated: 2025-08-27T14:50:32Z file_id: '20237' file_name: 2025_Sobarzo_JuanCarlos_Thesis.pdf file_size: 12667200 relation: main_file success: 1 - access_level: closed checksum: ca2f24e6c3b55912982521707552a0f5 content_type: application/x-zip-compressed creator: jsobarzo date_created: 2025-08-27T14:50:32Z date_updated: 2025-08-28T08:19:07Z file_id: '20238' file_name: 2025_Sobarzo_JuanCarlos_Thesis.zip file_size: 18940521 relation: source_file file_date_updated: 2025-08-28T08:19:07Z has_accepted_license: '1' language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: '96' project: - _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa call_identifier: H2020 grant_number: '949120' name: 'Tribocharge: a multi-scale approach to an enduring problem in physics' publication_identifier: isbn: - 978-3-99078-062-6 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12109' relation: part_of_dissertation status: public - id: '15322' relation: part_of_dissertation status: public - id: '19278' relation: part_of_dissertation status: public status: public supervisor: - first_name: Scott R full_name: Waitukaitis, Scott R id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87 last_name: Waitukaitis orcid: 0000-0002-2299-3176 title: 'Tribocharging of identical insulators : Triboelectric series, triboelectric cycles and surface charges' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19506' abstract: - lang: eng text: 'Hippocampal reactivation of waking neuronal assemblies in sleep is a key initial step of systems consolidation. Nevertheless, it is unclear whether reactivated assemblies are static or whether they reorganize gradually over prolonged sleep. We tracked reactivated CA1 assembly patterns over ∼20 h of sleep/rest periods and related them to assemblies seen before or after in a spatial learning paradigm using rats. We found that reactivated assembly patterns were gradually transformed and started to resemble those seen in the subsequent recall session. Periods of rapid eye movement (REM) sleep and non-REM (NREM) had antagonistic roles: whereas NREM accelerated the assembly drift, REM countered it. Moreover, only a subset of rate-changing pyramidal cells contributed to the drift, whereas stable-firing-rate cells maintained unaltered reactivation patterns. Our data suggest that prolonged sleep promotes the spontaneous reorganization of spatial assemblies, which can contribute to daily cognitive map changes or encoding new learning situations.' acknowledgement: We thank Andrea Cumpelik, Lisa Genzel, and Freya Ólafsdóttir for comments on an earlier version of the manuscript. This work was supported by the European Research Council (281511) and Austrian Science Fund (FWF I3713). article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Lars full_name: Bollmann, Lars id: 47AD3038-F248-11E8-B48F-1D18A9856A87 last_name: Bollmann - first_name: Peter full_name: Baracskay, Peter id: 361CC00E-F248-11E8-B48F-1D18A9856A87 last_name: Baracskay - first_name: Federico full_name: Stella, Federico id: 39AF1E74-F248-11E8-B48F-1D18A9856A87 last_name: Stella orcid: 0000-0001-9439-3148 - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 citation: ama: Bollmann L, Baracskay P, Stella F, Csicsvari JL. Sleep stages antagonistically modulate reactivation drift. Neuron. 2025;113(9):1446-1459.e6. doi:10.1016/j.neuron.2025.02.025 apa: Bollmann, L., Baracskay, P., Stella, F., & Csicsvari, J. L. (2025). Sleep stages antagonistically modulate reactivation drift. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2025.02.025 chicago: Bollmann, Lars, Peter Baracskay, Federico Stella, and Jozsef L Csicsvari. “Sleep Stages Antagonistically Modulate Reactivation Drift.” Neuron. Elsevier, 2025. https://doi.org/10.1016/j.neuron.2025.02.025. ieee: L. Bollmann, P. Baracskay, F. Stella, and J. L. Csicsvari, “Sleep stages antagonistically modulate reactivation drift,” Neuron, vol. 113, no. 9. Elsevier, p. 1446–1459.e6, 2025. ista: Bollmann L, Baracskay P, Stella F, Csicsvari JL. 2025. Sleep stages antagonistically modulate reactivation drift. Neuron. 113(9), 1446–1459.e6. mla: Bollmann, Lars, et al. “Sleep Stages Antagonistically Modulate Reactivation Drift.” Neuron, vol. 113, no. 9, Elsevier, 2025, p. 1446–1459.e6, doi:10.1016/j.neuron.2025.02.025. short: L. Bollmann, P. Baracskay, F. Stella, J.L. Csicsvari, Neuron 113 (2025) 1446–1459.e6. corr_author: '1' date_created: 2025-04-06T22:01:32Z date_published: 2025-05-07T00:00:00Z date_updated: 2026-04-28T13:39:22Z day: '07' ddc: - '570' department: - _id: JoCs doi: 10.1016/j.neuron.2025.02.025 ec_funded: 1 external_id: isi: - '001510440400001' pmid: - '40132588' file: - access_level: open_access checksum: 5e57852a45a78a751dd3a5e807bf015f content_type: application/pdf creator: dernst date_created: 2025-08-05T12:43:44Z date_updated: 2025-08-05T12:43:44Z file_id: '20133' file_name: 2025_Neuron_Bollmann.pdf file_size: 27047730 relation: main_file success: 1 file_date_updated: 2025-08-05T12:43:44Z has_accepted_license: '1' intvolume: ' 113' isi: 1 issue: '9' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: 1446-1459.e6 pmid: 1 project: - _id: 257A4776-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '281511' name: Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex - _id: 2654F984-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I 3713-B27 name: Interneuro plasticity during spatial learning publication: Neuron publication_identifier: eissn: - 1097-4199 issn: - 0896-6273 publication_status: published publisher: Elsevier quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/how-sleep-keeps-our-memories-fresh/ scopus_import: '1' status: public title: Sleep stages antagonistically modulate reactivation drift tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 113 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '19499' abstract: - lang: eng text: Quantum hardware is inherently fragile and noisy. We find that the accuracy of traditional quantum error correction algorithms can be improved depending on the hardware. Given different hardware specifications, we automatically synthesize hardware-optimal algorithms for parity correction, qubit resetting, and GHZ (Greenberger–Horne–Zeilinger) state preparation. Using stochastic techniques from computer science, our method presents a computational tool to compute exact accuracy guarantees and synthesize optimal algorithms that are often different from traditional ones. We also show that improvements can be gained with respect to the Qiskit transpiler as we compute the hardware-optimal qubit mapping for the GHZ state-preparation problem. acknowledgement: We thank the reviewers. In particular, they inspired us to analyze the reset and state-preparation problems, to compute optimal qubit mappings, and to apply our method to a quantum error correction scheme that includes both bitflip and phaseflip corrections. We also thank Raimundo Saona and Marek Chalupa for their time spent in insightful discussions. This research was partially supported by the European Research Council CoG 863818 (ForM-SMArt) grant. article_number: e2419273122 article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Stefanie full_name: Muroya Lei, Stefanie id: a376de31-8972-11ed-ae7b-d0251c13c8ff last_name: Muroya Lei - first_name: Krishnendu full_name: Chatterjee, Krishnendu id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87 last_name: Chatterjee orcid: 0000-0002-4561-241X - first_name: Thomas A full_name: Henzinger, Thomas A id: 40876CD8-F248-11E8-B48F-1D18A9856A87 last_name: Henzinger orcid: 0000-0002-2985-7724 citation: ama: Muroya Lei S, Chatterjee K, Henzinger TA. Hardware-optimal quantum algorithms. Proceedings of the National Academy of Sciences. 2025;122(12). doi:10.1073/pnas.2419273122 apa: Muroya Lei, S., Chatterjee, K., & Henzinger, T. A. (2025). Hardware-optimal quantum algorithms. Proceedings of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.2419273122 chicago: Muroya Lei, Stefanie, Krishnendu Chatterjee, and Thomas A Henzinger. “Hardware-Optimal Quantum Algorithms.” Proceedings of the National Academy of Sciences. National Academy of Sciences, 2025. https://doi.org/10.1073/pnas.2419273122. ieee: S. Muroya Lei, K. Chatterjee, and T. A. Henzinger, “Hardware-optimal quantum algorithms,” Proceedings of the National Academy of Sciences, vol. 122, no. 12. National Academy of Sciences, 2025. ista: Muroya Lei S, Chatterjee K, Henzinger TA. 2025. Hardware-optimal quantum algorithms. Proceedings of the National Academy of Sciences. 122(12), e2419273122. mla: Muroya Lei, Stefanie, et al. “Hardware-Optimal Quantum Algorithms.” Proceedings of the National Academy of Sciences, vol. 122, no. 12, e2419273122, National Academy of Sciences, 2025, doi:10.1073/pnas.2419273122. short: S. Muroya Lei, K. Chatterjee, T.A. Henzinger, Proceedings of the National Academy of Sciences 122 (2025). corr_author: '1' date_created: 2025-04-06T22:01:32Z date_published: 2025-03-25T00:00:00Z date_updated: 2026-04-28T13:41:14Z day: '25' ddc: - '000' department: - _id: KrCh - _id: ToHe doi: 10.1073/pnas.2419273122 ec_funded: 1 external_id: isi: - '001459435600001' pmid: - '40106357' file: - access_level: open_access checksum: 83501b8a65ee5fdd3f5604fc28eddc22 content_type: application/pdf creator: dernst date_created: 2025-04-07T11:42:22Z date_updated: 2025-04-07T11:42:22Z file_id: '19524' file_name: 2025_PNAS_Muroya.pdf file_size: 6805668 relation: main_file success: 1 file_date_updated: 2025-04-07T11:42:22Z has_accepted_license: '1' intvolume: ' 122' isi: 1 issue: '12' language: - iso: eng month: '03' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 0599E47C-7A3F-11EA-A408-12923DDC885E call_identifier: H2020 grant_number: '863818' name: 'Formal Methods for Stochastic Models: Algorithms and Applications' publication: Proceedings of the National Academy of Sciences publication_identifier: eissn: - 1091-6490 issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences quality_controlled: '1' related_material: link: - relation: software url: https://github.com/smml1996/algorithm_synthesis - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/hardware-optimal-quantum-algorithms/ scopus_import: '1' status: public title: Hardware-optimal quantum algorithms tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 122 year: '2025' ... --- OA_type: closed access _id: '19364' abstract: - lang: eng text: Thermoelectric coolers (TECs) are pivotal in modern heat management but face limitations in efficiency and manufacturing scalability. We address these challenges by using an extrusion-based 3D printing technique to fabricate high-performance thermoelectric materials. Our ink formulations ensure the integrity of the 3D-printed structure and effective particle bonding during sintering, achieving record-high figure of merit (zT) values of 1.42 for p-type bismuth antimony telluride [(Bi,Sb)2Te3] and 1.3 for n-type silver selenide (Ag2Se) materials at room temperature. The resulting TEC demonstrates a cooling temperature gradient of 50°C in air. Moreover, this scalable and cost-effective method circumvents energy-intensive and time-consuming steps, such as ingot preparation and subsequently machining processes, offering a transformative solution for thermoelectric device production and heralding a new era of efficient and sustainable thermoelectric technologies. acknowledged_ssus: - _id: EM-Fac - _id: LifeSc - _id: M-Shop - _id: NanoFab acknowledgement: This work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF), the Communication & Events facility, the Miba Machine Shop, and the Nanofabrication Facility (NNF). The Mechanical Response of Materials (MRM) Service Unit of the Technical University of Wien is acknowledged for Mechanical tests. X. L. Yan and S. Bühler-Paschen (Institute of Solid-State Physics, Technical University of Wien) are acknowledged for granting us access to their equipment, which allowed us to perform independent corroborative measurements. M. Qin is acknowledged for help with Au deposition and wire bonding for samples used for PPMS measurements. The lab of B. Hof and Z. Lu is acknowledged for help with rheological properties measurements. The members of the Ibáñez research group, especially N. Jakhar, C. Fiedler, and T. Kleinhanns, are acknowledged for their feedback on the manuscript and fruitful discussions. This work was financially supported by ISTA and the Werner Siemens Foundation. article_processing_charge: No article_type: original author: - first_name: Shengduo full_name: Xu, Shengduo id: 12ab8624-4c8a-11ec-9e11-e1ac2438f22f last_name: Xu - first_name: Sharona full_name: Horta, Sharona id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc last_name: Horta - first_name: Abayomi Q full_name: Lawal, Abayomi Q id: 5bdaf946-5355-11ee-ae5a-8061700bd605 last_name: Lawal - first_name: Krishnendu full_name: Maji, Krishnendu id: 76bc9e9f-ba0b-11ee-8184-90edabd17a58 last_name: Maji - first_name: Magali full_name: Lorion, Magali id: bc07ac4d-142e-11eb-a9d5-d72db792859d last_name: Lorion - first_name: Maria full_name: Ibáñez, Maria id: 43C61214-F248-11E8-B48F-1D18A9856A87 last_name: Ibáñez orcid: 0000-0001-5013-2843 citation: ama: Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. Science. 2025;387(6736):845-850. doi:10.1126/science.ads0426 apa: Xu, S., Horta, S., Lawal, A. Q., Maji, K., Lorion, M., & Ibáñez, M. (2025). Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. Science. AAAS. https://doi.org/10.1126/science.ads0426 chicago: Xu, Shengduo, Sharona Horta, Abayomi Q Lawal, Krishnendu Maji, Magali Lorion, and Maria Ibáñez. “Interfacial Bonding Enhances Thermoelectric Cooling in 3D-Printed Materials.” Science. AAAS, 2025. https://doi.org/10.1126/science.ads0426. ieee: S. Xu, S. Horta, A. Q. Lawal, K. Maji, M. Lorion, and M. Ibáñez, “Interfacial bonding enhances thermoelectric cooling in 3D-printed materials,” Science, vol. 387, no. 6736. AAAS, pp. 845–850, 2025. ista: Xu S, Horta S, Lawal AQ, Maji K, Lorion M, Ibáñez M. 2025. Interfacial bonding enhances thermoelectric cooling in 3D-printed materials. Science. 387(6736), 845–850. mla: Xu, Shengduo, et al. “Interfacial Bonding Enhances Thermoelectric Cooling in 3D-Printed Materials.” Science, vol. 387, no. 6736, AAAS, 2025, pp. 845–50, doi:10.1126/science.ads0426. short: S. Xu, S. Horta, A.Q. Lawal, K. Maji, M. Lorion, M. Ibáñez, Science 387 (2025) 845–850. corr_author: '1' date_created: 2025-03-09T23:01:26Z date_published: 2025-02-20T00:00:00Z date_updated: 2026-04-28T13:43:53Z day: '20' department: - _id: MaIb doi: 10.1126/science.ads0426 external_id: isi: - '001514422600026' pmid: - '39977506' intvolume: ' 387' isi: 1 issue: '6736' language: - iso: eng month: '02' oa_version: None page: 845-850 pmid: 1 project: - _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery' publication: Science publication_identifier: eissn: - 1095-9203 publication_status: published publisher: AAAS quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/cooling-materials-out-of-the-3d-printer/ scopus_import: '1' status: public title: Interfacial bonding enhances thermoelectric cooling in 3D-printed materials type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 387 year: '2025' ... --- OA_place: publisher _id: '19478' acknowledged_ssus: - _id: Bio - _id: LifeSc acknowledgement: "This project was funded by the European Research Council Advanced Grant (ETAP-742985),\r\nEuropean Research Council (ERC; 101142681 CYNIPS), Austrian Science Fund (FWF; P\r\n37051-B)." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Huihuang full_name: Chen, Huihuang id: 83c96512-15b2-11ec-abd3-b7eede36184f last_name: Chen citation: ama: Chen H. The cAMP second messenger in auxin signalling. 2025. doi:10.15479/AT-ISTA-19478 apa: Chen, H. (2025). The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19478 chicago: Chen, Huihuang. “The CAMP Second Messenger in Auxin Signalling.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19478. ieee: H. Chen, “The cAMP second messenger in auxin signalling,” Institute of Science and Technology Austria, 2025. ista: Chen H. 2025. The cAMP second messenger in auxin signalling. Institute of Science and Technology Austria. mla: Chen, Huihuang. The CAMP Second Messenger in Auxin Signalling. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19478. short: H. Chen, The CAMP Second Messenger in Auxin Signalling, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-04-04T07:48:24Z date_published: 2025-04-04T00:00:00Z date_updated: 2026-04-28T13:42:45Z day: '04' ddc: - '580' degree_awarded: PhD department: - _id: GradSch - _id: JiFr doi: 10.15479/AT-ISTA-19478 ec_funded: 1 file: - access_level: closed checksum: b154973663a1bba505683faab7ae5ead content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: hchen date_created: 2025-04-08T08:00:07Z date_updated: 2025-04-08T08:22:37Z file_id: '19526' file_name: Thesis_0403_Huihuang.docx file_size: 16344814 relation: source_file - access_level: closed checksum: 0099565f024388830c125ec17375c1a0 content_type: application/pdf creator: hchen date_created: 2025-04-08T08:00:06Z date_updated: 2025-04-09T13:53:38Z embargo: 2026-10-08 embargo_to: local file_id: '19527' file_name: Thesis_0406_PDFA_Huihuang_1.pdf file_size: 8482147 relation: main_file file_date_updated: 2025-04-09T13:53:38Z has_accepted_license: '1' language: - iso: eng month: '04' oa_version: Published Version page: '118' project: - _id: 261099A6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742985' name: Tracing Evolution of Auxin Transport and Polarity in Plants - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '13212' relation: part_of_dissertation status: public - id: '19421' relation: part_of_dissertation status: public status: public supervisor: - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 title: The cAMP second messenger in auxin signalling type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21706' abstract: - lang: eng text: "Consider a quadratic polynomial Q(ξ1, . . . , ξn) of independent Rademacher random variables ξ1, . . . , ξn. To what extent can Q(ξ1, . . . , ξn) concentrate on a single value? This quadratic version of the classical Littlewood–Offord problem was popularised by Costello, Tao and Vu in their study of symmetric random matrices. In this paper, we obtain an essentially optimal bound for this problem, as conjectured by Nguyen and Vu. Specifically, if Q(ξ1, . . . , ξn) ‘robustly depends on at least m of the ξi’ in the sense that there is no way to pin down the value of Q(ξ1, . . . , ξn) by fixing values for fewer than m of the variables ξi, then we have Pr[Q(ξ1, . . . , ξn) = 0] ≤ O(1/√m). This also implies a similar result in the case where ξ1, . . . , ξn have arbitrary distributions. Our proof combines a number of ideas that may be of independent interest, including an inductive decoupling scheme that reduces quadratic anticoncentration problems\r\nto high-dimensional linear anticoncentration problems. Also, one application of our main result is the resolution of a conjecture of Alon, Hefetz, Krivelevich and Tyomkyn related to graph inducibility. " acknowledgement: We would like to thank the anonymous referee for a number of helpful comments and suggestions. Matthew Kwan was supported by ERC Starting Grant “RANDSTRUCT” No. 101076777. Lisa Sauermann was supported in part by NSF Award DMS-2100157 and a Sloan Research Fellowship, and in part by the DFG Heisenberg Program. article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Matthew Alan full_name: Kwan, Matthew Alan id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3 last_name: Kwan orcid: 0000-0002-4003-7567 - first_name: Lisa full_name: Sauermann, Lisa last_name: Sauermann citation: ama: Kwan MA, Sauermann L. Resolution of the quadratic Littlewood–Offord problem. Compositio Mathematica. 2025;161(12):3089-3139. doi:10.1112/S0010437X25102789 apa: Kwan, M. A., & Sauermann, L. (2025). Resolution of the quadratic Littlewood–Offord problem. Compositio Mathematica. Cambridge University Press. https://doi.org/10.1112/S0010437X25102789 chicago: Kwan, Matthew Alan, and Lisa Sauermann. “Resolution of the Quadratic Littlewood–Offord Problem.” Compositio Mathematica. Cambridge University Press, 2025. https://doi.org/10.1112/S0010437X25102789. ieee: M. A. Kwan and L. Sauermann, “Resolution of the quadratic Littlewood–Offord problem,” Compositio Mathematica, vol. 161, no. 12. Cambridge University Press, pp. 3089–3139, 2025. ista: Kwan MA, Sauermann L. 2025. Resolution of the quadratic Littlewood–Offord problem. Compositio Mathematica. 161(12), 3089–3139. mla: Kwan, Matthew Alan, and Lisa Sauermann. “Resolution of the Quadratic Littlewood–Offord Problem.” Compositio Mathematica, vol. 161, no. 12, Cambridge University Press, 2025, pp. 3089–139, doi:10.1112/S0010437X25102789. short: M.A. Kwan, L. Sauermann, Compositio Mathematica 161 (2025) 3089–3139. corr_author: '1' date_created: 2026-04-12T22:01:48Z date_published: 2025-12-01T00:00:00Z date_updated: 2026-05-04T09:42:57Z day: '01' ddc: - '510' department: - _id: MaKw doi: 10.1112/S0010437X25102789 external_id: arxiv: - '2312.13826' file: - access_level: open_access checksum: bd3415bb435da9d0b39f6f9a18c61abb content_type: application/pdf creator: dernst date_created: 2026-05-04T09:41:25Z date_updated: 2026-05-04T09:41:25Z file_id: '21787' file_name: 2025_CompositioMath_Kwan.pdf file_size: 858727 relation: main_file success: 1 file_date_updated: 2026-05-04T09:41:25Z has_accepted_license: '1' intvolume: ' 161' issue: '12' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: 3089-3139 project: - _id: bd95085b-d553-11ed-ba76-e55d3349be45 grant_number: '101076777' name: Randomness and structure in combinatorics publication: Compositio Mathematica publication_identifier: eissn: - 1570-5846 issn: - 0010-437X publication_status: published publisher: Cambridge University Press quality_controlled: '1' scopus_import: '1' status: public title: Resolution of the quadratic Littlewood–Offord problem tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 161 year: '2025' ... --- OA_place: publisher _id: '20276' abstract: - lang: eng text: "Complex 3D shapes can be created by morphing flat 2D configurations. Such deformations\r\neither preserve the intrinsic material geometry (e.g., folding paper) or modify it through\r\nlocalized contraction. Once transformed, the 3D shape can be further controlled to achieve a\r\ntarget functionality. A key challenge is to take the material specifications and the actuation\r\nprocess as input to automatically design the target 3D shape and its functionality. This thesis\r\npresents two novel computational pipelines for the design and control of shape-morphing\r\nstructures used to create functional prototypes.\r\nThe first pipeline borrows from the art of origami to fold paper into intricate shapes and\r\napplies this principle to make 3D lighting displays. We introduce, PCBend a computational\r\ndesign approach that covers a surface with individually addressable RGB LEDs, effectively\r\nforming a low-resolution surface by folding rigid printed circuit boards (PCBs). We optimize\r\ncut patterns on PCBs to act as hinges and co-design LED placement, circuit routing, and\r\nfabrication constraints to produce PCB blueprints. The PCBs are fabricated using automated\r\nstandard manufacturing services with LEDs embedded on them. Finally, the fabricated PCBs\r\nare cut along the contour and folded onto a 3D-printed support. The 3D lighting display is\r\nthen controlled to display complex surface light patterns.\r\nCreating 3D shapes through folding is only possible if their planar configuration, called ”unfolding” exists without any distortion or overlap. Existing methods often permit distortion\r\nor require multiple patches, which are unsuitable for fabrication pipelines that rely on folding\r\nnon-stretchable materials. We reinforce such fabrication pipelines by providing a geometric\r\nrelaxation to the problem, where the input shape is modified to admit overlap-free unfolding.\r\nThe second fabrication pipeline extends shape morphing to soft robotics by emulating nature’s\r\nblueprint of distributed actuation. Inspired by vertebrates, we build musculoskeletal robots\r\nusing modular active actuators, employing Liquid Crystal Elastomers (LCEs) as shrinkable\r\nartificial muscles integrated with 3D-printed bones. The chemical composition of LCEs is\r\naltered to enable untethered actuation through infrared radiation, allowing active control of\r\nindividual muscles and their corresponding bones. The combined motion of individual bones\r\ndefines the robot’s overall shape and functionality. Our proposed system significantly expands\r\nboth the design and control spaces of soft robots, which we harness using our computational\r\ndesign tools. We build several physical robots that exhibit complex shape morphing and varied\r\nterrain navigation, showcasing the versatility of our pipeline.\r\nThis thesis explores applications ranging from intricate light patterns displayed on 3D shapes\r\nformed by folding rigid PCBs to untethered robots that use contractile muscles to exhibit\r\nshape morphing and locomotion. Through these examples, the thesis highlights how computational design and distributed actuation, integrated with novel materials, can transform\r\npassive structures into functional prototypes." acknowledgement: "Financial support was provided by the European Research Council (ERC) under grant agreement No 715767 - MATERIALIZABLE: Intelligent fabrication-oriented Computational Design\r\nand Modeling that I gratefully acknowledge.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Manas full_name: Bhargava, Manas id: FF8FA64C-AA6A-11E9-99AD-50D4E5697425 last_name: Bhargava orcid: 0009-0007-6138-6890 citation: ama: 'Bhargava M. Design and control of deformable structures : From PCB lighting displays to elastomer robots. 2025. doi:10.15479/AT-ISTA-20276' apa: 'Bhargava, M. (2025). Design and control of deformable structures : From PCB lighting displays to elastomer robots. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20276' chicago: 'Bhargava, Manas. “Design and Control of Deformable Structures : From PCB Lighting Displays to Elastomer Robots.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20276.' ieee: 'M. Bhargava, “Design and control of deformable structures : From PCB lighting displays to elastomer robots,” Institute of Science and Technology Austria, 2025.' ista: 'Bhargava M. 2025. Design and control of deformable structures : From PCB lighting displays to elastomer robots. Institute of Science and Technology Austria.' mla: 'Bhargava, Manas. Design and Control of Deformable Structures : From PCB Lighting Displays to Elastomer Robots. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20276.' short: 'M. Bhargava, Design and Control of Deformable Structures : From PCB Lighting Displays to Elastomer Robots, Institute of Science and Technology Austria, 2025.' corr_author: '1' date_created: 2025-09-02T14:48:39Z date_published: 2025-09-02T00:00:00Z date_updated: 2026-05-04T12:41:53Z day: '02' ddc: - '000' degree_awarded: PhD department: - _id: GradSch - _id: BeBi doi: 10.15479/AT-ISTA-20276 ec_funded: 1 file: - access_level: open_access checksum: 5baf8ca46c86a94fc8380ff1007aabd4 content_type: application/pdf creator: mbhargav date_created: 2025-09-03T10:40:52Z date_updated: 2025-09-03T10:40:52Z file_id: '20284' file_name: 2025-Bhargava-Manas-Thesis.pdf file_size: 161436245 relation: main_file success: 1 - access_level: closed checksum: 66878fafbc0074f88ddd18f24a9fc647 content_type: application/x-zip-compressed creator: mbhargav date_created: 2025-09-03T13:18:05Z date_updated: 2025-09-04T09:22:29Z file_id: '20285' file_name: manas_phd_thesis_source_files.zip file_size: 198831315 relation: source_file file_date_updated: 2025-09-04T09:22:29Z has_accepted_license: '1' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: '96' project: - _id: 24F9549A-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715767' name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling' publication_identifier: isbn: - 978-3-99078-065-7 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '13049' relation: part_of_dissertation status: public - id: '18565' relation: part_of_dissertation status: public - id: '20286' relation: part_of_dissertation status: public status: public supervisor: - first_name: Bernd full_name: Bickel, Bernd id: 49876194-F248-11E8-B48F-1D18A9856A87 last_name: Bickel orcid: 0000-0001-6511-9385 title: 'Design and control of deformable structures : From PCB lighting displays to elastomer robots' tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '18565' abstract: - lang: eng text: 'We present a computational approach for unfolding 3D shapes isometrically into the plane as a single patch without overlapping triangles. This is a hard, sometimes impossible, problem, which existing methods are forced to soften by allowing for map distortions or multiple patches. Instead, we propose a geometric relaxation of the problem: We modify the input shape until it admits an overlap‐free unfolding. We achieve this by locally displacing vertices and collapsing edges, guided by the unfolding process. We validate our algorithm quantitatively and qualitatively on a large dataset of complex shapes and show its proficiency by fabricating real shapes from paper.' acknowledgement: Researchers from INRIA received support from the DORNELL Inria Challenge. Silvia Sellán acknowledges support from NSERC Vanier Doctoral Scholarship and an MIT SoE Postdoctoral Fellowship for Engineering Excellence. article_number: e15269 article_processing_charge: Yes (via OA deal) article_type: original arxiv: 1 author: - first_name: Manas full_name: Bhargava, Manas id: FF8FA64C-AA6A-11E9-99AD-50D4E5697425 last_name: Bhargava orcid: 0009-0007-6138-6890 - first_name: Camille full_name: Schreck, Camille id: 2B14B676-F248-11E8-B48F-1D18A9856A87 last_name: Schreck - first_name: M. full_name: Freire, M. last_name: Freire - first_name: P. A. full_name: Hugron, P. A. last_name: Hugron - first_name: S. full_name: Lefebvre, S. last_name: Lefebvre - first_name: S. full_name: Sellán, S. last_name: Sellán - first_name: Bernd full_name: Bickel, Bernd id: 49876194-F248-11E8-B48F-1D18A9856A87 last_name: Bickel orcid: 0000-0001-6511-9385 citation: ama: Bhargava M, Schreck C, Freire M, et al. Mesh simplification for unfolding. Computer Graphics Forum. 2025;44(1). doi:10.1111/cgf.15269 apa: Bhargava, M., Schreck, C., Freire, M., Hugron, P. A., Lefebvre, S., Sellán, S., & Bickel, B. (2025). Mesh simplification for unfolding. Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.15269 chicago: Bhargava, Manas, Camille Schreck, M. Freire, P. A. Hugron, S. Lefebvre, S. Sellán, and Bernd Bickel. “Mesh Simplification for Unfolding.” Computer Graphics Forum. Wiley, 2025. https://doi.org/10.1111/cgf.15269. ieee: M. Bhargava et al., “Mesh simplification for unfolding,” Computer Graphics Forum, vol. 44, no. 1. Wiley, 2025. ista: Bhargava M, Schreck C, Freire M, Hugron PA, Lefebvre S, Sellán S, Bickel B. 2025. Mesh simplification for unfolding. Computer Graphics Forum. 44(1), e15269. mla: Bhargava, Manas, et al. “Mesh Simplification for Unfolding.” Computer Graphics Forum, vol. 44, no. 1, e15269, Wiley, 2025, doi:10.1111/cgf.15269. short: M. Bhargava, C. Schreck, M. Freire, P.A. Hugron, S. Lefebvre, S. Sellán, B. Bickel, Computer Graphics Forum 44 (2025). corr_author: '1' date_created: 2024-11-19T09:14:32Z date_published: 2025-02-01T00:00:00Z date_updated: 2026-05-04T12:41:52Z day: '01' ddc: - '006' department: - _id: GradSch - _id: BeBi doi: 10.1111/cgf.15269 external_id: arxiv: - '2408.06944' isi: - '001357046100001' file: - access_level: open_access checksum: 34acdd9bfbe43f00eb6c7656afef3ac6 content_type: video/mp4 creator: mbhargav date_created: 2024-11-19T09:23:20Z date_updated: 2024-11-19T09:23:20Z file_id: '18567' file_name: Mesh_Simplification_For_Unfolding_cgf_submission_supplemental_video.mp4 file_size: 36999751 relation: main_file success: 1 - access_level: open_access checksum: efb06b01bae37f470954601bc004374d content_type: application/pdf creator: dernst date_created: 2025-04-16T09:06:45Z date_updated: 2025-04-16T09:06:45Z file_id: '19576' file_name: 2025_CompGraphicsForum_Bhargava.pdf file_size: 5188265 relation: main_file success: 1 file_date_updated: 2025-04-16T09:06:45Z has_accepted_license: '1' intvolume: ' 44' isi: 1 issue: '1' keyword: - fabrication - single patch unfolding - mesh simplification language: - iso: eng month: '02' oa: 1 oa_version: Published Version publication: Computer Graphics Forum publication_identifier: eissn: - 1467-8659 issn: - 0167-7055 publication_status: published publisher: Wiley quality_controlled: '1' related_material: record: - id: '20276' relation: dissertation_contains status: public scopus_import: '1' status: public title: Mesh simplification for unfolding tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 44 year: '2025' ... --- OA_place: repository _id: '20286' abstract: - lang: eng text: "Natural organisms utilize distributed actuation through their musculoskeletal\r\nsystems to adapt their gait for traversing diverse terrains or to morph their\r\nbodies for varied tasks. A longstanding challenge in robotics is to emulate\r\nthis capability of natural organisms, which has motivated the development of\r\nnumerous soft robotic systems. However, such systems are generally optimized\r\nfor a single functionality, lack the ability to change form or function on\r\ndemand, or remain tethered to bulky control systems. To address these\r\nlimitations, we present a framework for designing and controlling robots that\r\nutilize distributed actuation. We propose a novel building block that\r\nintegrates 3D-printed bones with liquid crystal elastomer (LCE) muscles as\r\nlightweight actuators, enabling the modular assembly of musculoskeletal robots.\r\nWe developed LCE rods that contract in response to infrared radiation, thereby\r\nproviding localized, untethered control over the distributed skeletal network\r\nand producing global deformations of the robot. To fully capitalize on the\r\nextensive design space, we introduce two computational tools: one for\r\noptimizing the robot's skeletal graph to achieve multiple target deformations,\r\nand another for co-optimizing skeletal designs and control gaits to realize\r\ndesired locomotion. We validate our framework by constructing several robots\r\nthat demonstrate complex shape morphing, diverse control schemes, and\r\nenvironmental adaptability. Our system integrates advances in modular material\r\nbuilding, untethered and distributed control, and computational design to\r\nintroduce a new generation of robots that brings us closer to the capabilities\r\nof living organisms." acknowledgement: "The authors express gratitude to Magali Lorion for assisting in the initial fabrication of LCEs,\r\nPengbin Tang for providing the code for simulating discrete elastic rods, the Imaging and\r\nOptics Facility at ISTA for assisting with the spectrometry measurements, and the MIBA\r\nmachine shop at ISTA for their support in manufacturing various devices.\r\nFunding: This project was supported by the European Research Council (ERC) under\r\nthe European Union’s Horizon 2020 research and innovation program (Grant Agreement No.\r\n715767 -– MATERIALIZABLE)." article_processing_charge: No arxiv: 1 author: - first_name: Manas full_name: Bhargava, Manas id: FF8FA64C-AA6A-11E9-99AD-50D4E5697425 last_name: Bhargava orcid: 0009-0007-6138-6890 - first_name: Takefumi full_name: Hiraki, Takefumi last_name: Hiraki - first_name: Irina-Malina full_name: Strugaru, Irina-Malina id: 2afc607f-f128-11eb-9611-8f2a0dfcf074 last_name: Strugaru - first_name: Yuhan full_name: Zhang, Yuhan last_name: Zhang - first_name: Michael full_name: Piovarci, Michael id: 62E473F4-5C99-11EA-A40E-AF823DDC885E last_name: Piovarci orcid: 0000-0002-5062-4474 - first_name: Chiara full_name: Daraio, Chiara last_name: Daraio - first_name: Daisuke full_name: Iwai, Daisuke last_name: Iwai - first_name: Bernd full_name: Bickel, Bernd id: 49876194-F248-11E8-B48F-1D18A9856A87 last_name: Bickel orcid: 0000-0001-6511-9385 citation: ama: Bhargava M, Hiraki T, Strugaru I-M, et al. Computational design and fabrication of modular robots with untethered control. arXiv. doi:10.48550/arXiv.2508.05410 apa: Bhargava, M., Hiraki, T., Strugaru, I.-M., Zhang, Y., Piovarci, M., Daraio, C., … Bickel, B. (n.d.). Computational design and fabrication of modular robots with untethered control. arXiv. https://doi.org/10.48550/arXiv.2508.05410 chicago: Bhargava, Manas, Takefumi Hiraki, Irina-Malina Strugaru, Yuhan Zhang, Michael Piovarci, Chiara Daraio, Daisuke Iwai, and Bernd Bickel. “Computational Design and Fabrication of Modular Robots with Untethered Control.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2508.05410. ieee: M. Bhargava et al., “Computational design and fabrication of modular robots with untethered control,” arXiv. . ista: Bhargava M, Hiraki T, Strugaru I-M, Zhang Y, Piovarci M, Daraio C, Iwai D, Bickel B. Computational design and fabrication of modular robots with untethered control. arXiv, 10.48550/arXiv.2508.05410. mla: Bhargava, Manas, et al. “Computational Design and Fabrication of Modular Robots with Untethered Control.” ArXiv, doi:10.48550/arXiv.2508.05410. short: M. Bhargava, T. Hiraki, I.-M. Strugaru, Y. Zhang, M. Piovarci, C. Daraio, D. Iwai, B. Bickel, ArXiv (n.d.). corr_author: '1' date_created: 2025-09-04T09:14:11Z date_published: 2025-08-31T00:00:00Z date_updated: 2026-05-04T12:41:52Z day: '31' department: - _id: BeBi doi: 10.48550/arXiv.2508.05410 ec_funded: 1 external_id: arxiv: - '2508.05410' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2508.05410 month: '08' oa: 1 oa_version: Preprint project: - _id: 24F9549A-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715767' name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling' publication: arXiv publication_status: draft related_material: record: - id: '20276' relation: dissertation_contains status: public status: public title: Computational design and fabrication of modular robots with untethered control tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: preprint user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2025' ...