---
OA_place: repository
OA_type: free access
_id: '17805'
abstract:
- lang: eng
text: We report on the detection by Swift of GRB 080913, and subsequent optical/near-infrared
follow-up observations by GROND, which led to the discovery of its optical/NIR
afterglow and the recognition of its high-z nature via the detection of a spectral
break between the i' and z' bands. Spectroscopy obtained at the ESO-VLT revealed
a continuum extending down to λ = 9400 Å, and zero flux for 7500 Å<λ < 9400 Å,
which we interpret as the onset of a Gunn–Peterson trough at z = 6.695± 0.025
(95.5% confidence level), making GRB 080913 the highest-redshift gamma-ray burst
(GRB) to date, and more distant than the highest-redshift QSO. We note that many
redshift indicators that are based on promptly available burst or afterglow properties
have failed for GRB 080913. We report on our follow-up campaign and compare the
properties of GRB 080913 with bursts at lower redshift. In particular, since the
afterglow of this burst is fainter than typical for GRBs, we show that 2 m class
telescopes can identify most high-redshift GRBs.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: J.
full_name: Greiner, J.
last_name: Greiner
- first_name: T.
full_name: Krühler, T.
last_name: Krühler
- first_name: J. P. U.
full_name: Fynbo, J. P. U.
last_name: Fynbo
- first_name: A.
full_name: Rossi, A.
last_name: Rossi
- first_name: R.
full_name: Schwarz, R.
last_name: Schwarz
- first_name: S.
full_name: Klose, S.
last_name: Klose
- first_name: S.
full_name: Savaglio, S.
last_name: Savaglio
- first_name: N. R.
full_name: Tanvir, N. R.
last_name: Tanvir
- first_name: S.
full_name: McBreen, S.
last_name: McBreen
- first_name: T.
full_name: Totani, T.
last_name: Totani
- first_name: B. B.
full_name: Zhang, B. B.
last_name: Zhang
- first_name: X. F.
full_name: Wu, X. F.
last_name: Wu
- first_name: D.
full_name: Watson, D.
last_name: Watson
- first_name: S. D.
full_name: Barthelmy, S. D.
last_name: Barthelmy
- first_name: A. P.
full_name: Beardmore, A. P.
last_name: Beardmore
- first_name: P.
full_name: Ferrero, P.
last_name: Ferrero
- first_name: N.
full_name: Gehrels, N.
last_name: Gehrels
- first_name: D. A.
full_name: Kann, D. A.
last_name: Kann
- first_name: N.
full_name: Kawai, N.
last_name: Kawai
- first_name: A. Küpcü
full_name: Yoldaş, A. Küpcü
last_name: Yoldaş
- first_name: P.
full_name: Mészáros, P.
last_name: Mészáros
- first_name: B.
full_name: Milvang-Jensen, B.
last_name: Milvang-Jensen
- first_name: S. R.
full_name: Oates, S. R.
last_name: Oates
- first_name: D.
full_name: Pierini, D.
last_name: Pierini
- first_name: P.
full_name: Schady, P.
last_name: Schady
- first_name: K.
full_name: Toma, K.
last_name: Toma
- first_name: P. M.
full_name: Vreeswijk, P. M.
last_name: Vreeswijk
- first_name: A.
full_name: Yoldaş, A.
last_name: Yoldaş
- first_name: B.
full_name: Zhang, B.
last_name: Zhang
- first_name: P.
full_name: Afonso, P.
last_name: Afonso
- first_name: K.
full_name: Aoki, K.
last_name: Aoki
- first_name: D. N.
full_name: Burrows, D. N.
last_name: Burrows
- first_name: C.
full_name: Clemens, C.
last_name: Clemens
- first_name: R.
full_name: Filgas, R.
last_name: Filgas
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
- first_name: D. H.
full_name: Hartmann, D. H.
last_name: Hartmann
- first_name: G.
full_name: Hasinger, G.
last_name: Hasinger
- first_name: J.
full_name: Hjorth, J.
last_name: Hjorth
- first_name: E.
full_name: Jehin, E.
last_name: Jehin
- first_name: A. J.
full_name: Levan, A. J.
last_name: Levan
- first_name: E. W.
full_name: Liang, E. W.
last_name: Liang
- first_name: D.
full_name: Malesani, D.
last_name: Malesani
- first_name: T.-S.
full_name: Pyo, T.-S.
last_name: Pyo
- first_name: S.
full_name: Schulze, S.
last_name: Schulze
- first_name: G.
full_name: Szokoly, G.
last_name: Szokoly
- first_name: K.
full_name: Terada, K.
last_name: Terada
- first_name: K.
full_name: Wiersema, K.
last_name: Wiersema
citation:
ama: Greiner J, Krühler T, Fynbo JPU, et al. GRB 080913 at redshift 6.7. The
Astrophysical Journal. 2009;693(2):1610-1620. doi:10.1088/0004-637x/693/2/1610
apa: Greiner, J., Krühler, T., Fynbo, J. P. U., Rossi, A., Schwarz, R., Klose, S.,
… Wiersema, K. (2009). GRB 080913 at redshift 6.7. The Astrophysical Journal.
American Astronomical Society. https://doi.org/10.1088/0004-637x/693/2/1610
chicago: Greiner, J., T. Krühler, J. P. U. Fynbo, A. Rossi, R. Schwarz, S. Klose,
S. Savaglio, et al. “GRB 080913 at Redshift 6.7.” The Astrophysical Journal.
American Astronomical Society, 2009. https://doi.org/10.1088/0004-637x/693/2/1610.
ieee: J. Greiner et al., “GRB 080913 at redshift 6.7,” The Astrophysical
Journal, vol. 693, no. 2. American Astronomical Society, pp. 1610–1620, 2009.
ista: Greiner J, Krühler T, Fynbo JPU, Rossi A, Schwarz R, Klose S, Savaglio S,
Tanvir NR, McBreen S, Totani T, Zhang BB, Wu XF, Watson D, Barthelmy SD, Beardmore
AP, Ferrero P, Gehrels N, Kann DA, Kawai N, Yoldaş AK, Mészáros P, Milvang-Jensen
B, Oates SR, Pierini D, Schady P, Toma K, Vreeswijk PM, Yoldaş A, Zhang B, Afonso
P, Aoki K, Burrows DN, Clemens C, Filgas R, Haiman Z, Hartmann DH, Hasinger G,
Hjorth J, Jehin E, Levan AJ, Liang EW, Malesani D, Pyo T-S, Schulze S, Szokoly
G, Terada K, Wiersema K. 2009. GRB 080913 at redshift 6.7. The Astrophysical Journal.
693(2), 1610–1620.
mla: Greiner, J., et al. “GRB 080913 at Redshift 6.7.” The Astrophysical Journal,
vol. 693, no. 2, American Astronomical Society, 2009, pp. 1610–20, doi:10.1088/0004-637x/693/2/1610.
short: J. Greiner, T. Krühler, J.P.U. Fynbo, A. Rossi, R. Schwarz, S. Klose, S.
Savaglio, N.R. Tanvir, S. McBreen, T. Totani, B.B. Zhang, X.F. Wu, D. Watson,
S.D. Barthelmy, A.P. Beardmore, P. Ferrero, N. Gehrels, D.A. Kann, N. Kawai, A.K.
Yoldaş, P. Mészáros, B. Milvang-Jensen, S.R. Oates, D. Pierini, P. Schady, K.
Toma, P.M. Vreeswijk, A. Yoldaş, B. Zhang, P. Afonso, K. Aoki, D.N. Burrows, C.
Clemens, R. Filgas, Z. Haiman, D.H. Hartmann, G. Hasinger, J. Hjorth, E. Jehin,
A.J. Levan, E.W. Liang, D. Malesani, T.-S. Pyo, S. Schulze, G. Szokoly, K. Terada,
K. Wiersema, The Astrophysical Journal 693 (2009) 1610–1620.
date_created: 2024-09-06T11:33:49Z
date_published: 2009-03-10T00:00:00Z
date_updated: 2024-11-12T10:14:41Z
day: '10'
doi: 10.1088/0004-637x/693/2/1610
extern: '1'
external_id:
arxiv:
- '0810.2314'
intvolume: ' 693'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.0810.2314
month: '03'
oa: 1
oa_version: Preprint
page: 1610-1620
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: GRB 080913 at redshift 6.7
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 693
year: '2009'
...
---
_id: '17809'
abstract:
- lang: eng
text: Supermassive black hole binaries (SMBHBs) in galactic nuclei are thought to
be a common by-product of major galaxy mergers. We use simple disk models for
the circumbinary gas and for the binary–disk interaction to follow the orbital
decay of SMBHBs with a range of total masses (M) and mass ratios (q), through
physically distinct regions of the disk, until gravitational waves (GWs) take
over their evolution. Prior to the GW-driven phase, the viscous decay is generically
in the stalled "secondary-dominated" regime. SMBHBs spend a non-negligible fraction
of a fiducial time of 107 yr at orbital periods between days ≲torb≲ yr, and we
argue that they may be sufficiently common to be detectable, provided they are
luminous during these stages. A dedicated optical or X-ray survey could identify
coalescing SMBHBs statistically, as a population of periodically variable quasars,
whose abundance obeys the scaling Nvar ∝ tαvar within a range of periods around
tvar∼ tens of weeks. SMBHBs with M ≲ 107 M☉, with 0.5 ≲ α ≲ 1.5, would probe the
physics of viscous orbital decay, whereas the detection of a population of higher-mass
binaries, with α = 8/3, would confirm that their decay is driven by GWs. The lowest-mass
SMBHBs (M ≲ 105–6 M☉) enter the GW-driven regime at short orbital periods, when
they are already in the frequency band of the Laser Interferometric Space Antenna
(LISA). While viscous processes are negligible in the last few years of coalescence,
they could reduce the amplitude of any unresolved background due to near-stationary
LISA sources. We discuss modest constraints on the SMBHB population already available
from existing data, and the sensitivity and sky coverage requirements for a detection
in future surveys. SMBHBs may also be identified from velocity shifts in their
spectra; we discuss the expected abundance of SMBHBs as a function of their orbital
velocity.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
- first_name: Bence
full_name: Kocsis, Bence
last_name: Kocsis
- first_name: Kristen
full_name: Menou, Kristen
last_name: Menou
citation:
ama: Haiman Z, Kocsis B, Menou K. The population of viscosity- and gravitational
wave-driven supermassive black hole binaries among luminous active galactic nuclei.
The Astrophysical Journal. 2009;700(2):1952-1969. doi:10.1088/0004-637x/700/2/1952
apa: Haiman, Z., Kocsis, B., & Menou, K. (2009). The population of viscosity-
and gravitational wave-driven supermassive black hole binaries among luminous
active galactic nuclei. The Astrophysical Journal. American Astronomical
Society. https://doi.org/10.1088/0004-637x/700/2/1952
chicago: Haiman, Zoltán, Bence Kocsis, and Kristen Menou. “The Population of Viscosity-
and Gravitational Wave-Driven Supermassive Black Hole Binaries among Luminous
Active Galactic Nuclei.” The Astrophysical Journal. American Astronomical
Society, 2009. https://doi.org/10.1088/0004-637x/700/2/1952.
ieee: Z. Haiman, B. Kocsis, and K. Menou, “The population of viscosity- and gravitational
wave-driven supermassive black hole binaries among luminous active galactic nuclei,”
The Astrophysical Journal, vol. 700, no. 2. American Astronomical Society,
pp. 1952–1969, 2009.
ista: Haiman Z, Kocsis B, Menou K. 2009. The population of viscosity- and gravitational
wave-driven supermassive black hole binaries among luminous active galactic nuclei.
The Astrophysical Journal. 700(2), 1952–1969.
mla: Haiman, Zoltán, et al. “The Population of Viscosity- and Gravitational Wave-Driven
Supermassive Black Hole Binaries among Luminous Active Galactic Nuclei.” The
Astrophysical Journal, vol. 700, no. 2, American Astronomical Society, 2009,
pp. 1952–69, doi:10.1088/0004-637x/700/2/1952.
short: Z. Haiman, B. Kocsis, K. Menou, The Astrophysical Journal 700 (2009) 1952–1969.
date_created: 2024-09-06T11:38:01Z
date_published: 2009-07-17T00:00:00Z
date_updated: 2024-09-18T12:26:50Z
day: '17'
doi: 10.1088/0004-637x/700/2/1952
extern: '1'
intvolume: ' 700'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1088/0004-637X/700/2/1952
month: '07'
oa: 1
oa_version: Published Version
page: 1952-1969
publication: The Astrophysical Journal
publication_identifier:
issn:
- 0004-637X
- 1538-4357
publication_status: published
publisher: American Astronomical Society
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.3847/1538-4357/ac93f7
scopus_import: '1'
status: public
title: The population of viscosity- and gravitational wave-driven supermassive black
hole binaries among luminous active galactic nuclei
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 700
year: '2009'
...
---
_id: '1798'
abstract:
- lang: eng
text: The mammalian brain is assembled from thousands of neuronal cell types that
are organized in distinct circuits to perform behaviorally relevant computations.
Transgenic mouse lines with selectively marked cell types would facilitate our
ability to dissect functional components of complex circuits. We carried out a
screen for cell type-specific green fluorescent protein expression in the retina
using BAC transgenic mice from the GENSAT project. Among others, we identified
mouse lines in which the inhibitory cell types of the night vision and directional
selective circuit were selectively labeled. We quantified the stratification patterns
to predict potential synaptic connectivity between marked cells of different lines
and found that some of the lines enabled targeted recordings and imaging of cell
types from developing or mature retinal circuits. Our results suggest the potential
use of a stratification-based screening approach for characterizing neuronal circuitry
in other layered brain structures, such as the neocortex.
acknowledgement: This study was supported by Friedrich Miescher Institute funds, a
US Office of Naval Research Naval International Cooperative Opportunities in Science
and Technology Program grant, a Marie Curie Excellence grant, a National Center
for Competence in Research in Genetics grant and a European Union HEALTH-F2-223156
grant to B.R., and by National Institute of Neurological Disorders and Stroke contracts
N01NS02331 and HHSN271200723701C to N.H.
author:
- first_name: Sandra
full_name: Sandra Siegert
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Brigitte
full_name: Scherf, Brigitte G
last_name: Scherf
- first_name: Karina
full_name: Del Punta, Karina
last_name: Del Punta
- first_name: Nick
full_name: Didkovsky, Nick
last_name: Didkovsky
- first_name: Nathaniel
full_name: Heintz, Nathaniel M
last_name: Heintz
- first_name: Botond
full_name: Roska, Botond M
last_name: Roska
citation:
ama: Siegert S, Scherf B, Del Punta K, Didkovsky N, Heintz N, Roska B. Genetic address
book for retinal cell types. Nature Neuroscience. 2009;12(9):1197-1204.
doi:10.1038/nn.2370
apa: Siegert, S., Scherf, B., Del Punta, K., Didkovsky, N., Heintz, N., & Roska,
B. (2009). Genetic address book for retinal cell types. Nature Neuroscience.
Nature Publishing Group. https://doi.org/10.1038/nn.2370
chicago: Siegert, Sandra, Brigitte Scherf, Karina Del Punta, Nick Didkovsky, Nathaniel
Heintz, and Botond Roska. “Genetic Address Book for Retinal Cell Types.” Nature
Neuroscience. Nature Publishing Group, 2009. https://doi.org/10.1038/nn.2370.
ieee: S. Siegert, B. Scherf, K. Del Punta, N. Didkovsky, N. Heintz, and B. Roska,
“Genetic address book for retinal cell types,” Nature Neuroscience, vol.
12, no. 9. Nature Publishing Group, pp. 1197–1204, 2009.
ista: Siegert S, Scherf B, Del Punta K, Didkovsky N, Heintz N, Roska B. 2009. Genetic
address book for retinal cell types. Nature Neuroscience. 12(9), 1197–1204.
mla: Siegert, Sandra, et al. “Genetic Address Book for Retinal Cell Types.” Nature
Neuroscience, vol. 12, no. 9, Nature Publishing Group, 2009, pp. 1197–204,
doi:10.1038/nn.2370.
short: S. Siegert, B. Scherf, K. Del Punta, N. Didkovsky, N. Heintz, B. Roska, Nature
Neuroscience 12 (2009) 1197–1204.
date_created: 2018-12-11T11:54:04Z
date_published: 2009-09-01T00:00:00Z
date_updated: 2021-01-12T06:53:16Z
day: '01'
doi: 10.1038/nn.2370
extern: 1
intvolume: ' 12'
issue: '9'
month: '09'
page: 1197 - 1204
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '5312'
quality_controlled: 0
status: public
title: Genetic address book for retinal cell types
type: journal_article
volume: 12
year: '2009'
...
---
_id: '1799'
abstract:
- lang: eng
text: 'The detection of approaching objects, such as looming predators, is necessary
for survival. Which neurons and circuits mediate this function? We combined genetic
labeling of cell types, two-photon microscopy, electrophysiology and theoretical
modeling to address this question. We identify an approach-sensitive ganglion
cell type in the mouse retina, resolve elements of its afferent neural circuit,
and describe how these confer approach sensitivity on the ganglion cell. The circuit''s
essential building block is a rapid inhibitory pathway: it selectively suppresses
responses to non-approaching objects. This rapid inhibitory pathway, which includes
AII amacrine cells connected to bipolar cells through electrical synapses, was
previously described in the context of night-time vision. In the daytime conditions
of our experiments, the same pathway conveys signals in the reverse direction.
The dual use of a neural pathway in different physiological conditions illustrates
the efficiency with which several functions can be accommodated in a single circuit.'
acknowledgement: The study was supported by Friedrich Miescher Institute funds, a
US Office of Naval Research Naval International Cooperative Opportunities in Science
and Technology program grant, a Marie Curie Excellence Grant, a Human Frontier Science
Program Young Investigator grant, a National Centers of Competence in Research in
Genetics grant and a European Union HEALTH-F2-223156 grant to B.R., a Marie Curie
Postdoctoral Fellowship to T.A.M., the Centre National de la Recherche Scientifique
through the Unité Mixte de Recherche 8550 to R.A.d.S.
author:
- first_name: Thomas
full_name: Münch, Thomas A
last_name: Münch
- first_name: Ravá
full_name: Da Silveira, Ravá A
last_name: Da Silveira
- first_name: Sandra
full_name: Sandra Siegert
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Tim
full_name: Viney, Tim J
last_name: Viney
- first_name: Gautam
full_name: Awatramani, Gautam B
last_name: Awatramani
- first_name: Botond
full_name: Roska, Botond M
last_name: Roska
citation:
ama: Münch T, Da Silveira R, Siegert S, Viney T, Awatramani G, Roska B. Approach
sensitivity in the retina processed by a multifunctional neural circuit. Nature
Neuroscience. 2009;12(10):1308-1316. doi:10.1038/nn.2389
apa: Münch, T., Da Silveira, R., Siegert, S., Viney, T., Awatramani, G., & Roska,
B. (2009). Approach sensitivity in the retina processed by a multifunctional neural
circuit. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2389
chicago: Münch, Thomas, Ravá Da Silveira, Sandra Siegert, Tim Viney, Gautam Awatramani,
and Botond Roska. “Approach Sensitivity in the Retina Processed by a Multifunctional
Neural Circuit.” Nature Neuroscience. Nature Publishing Group, 2009. https://doi.org/10.1038/nn.2389.
ieee: T. Münch, R. Da Silveira, S. Siegert, T. Viney, G. Awatramani, and B. Roska,
“Approach sensitivity in the retina processed by a multifunctional neural circuit,”
Nature Neuroscience, vol. 12, no. 10. Nature Publishing Group, pp. 1308–1316,
2009.
ista: Münch T, Da Silveira R, Siegert S, Viney T, Awatramani G, Roska B. 2009. Approach
sensitivity in the retina processed by a multifunctional neural circuit. Nature
Neuroscience. 12(10), 1308–1316.
mla: Münch, Thomas, et al. “Approach Sensitivity in the Retina Processed by a Multifunctional
Neural Circuit.” Nature Neuroscience, vol. 12, no. 10, Nature Publishing
Group, 2009, pp. 1308–16, doi:10.1038/nn.2389.
short: T. Münch, R. Da Silveira, S. Siegert, T. Viney, G. Awatramani, B. Roska,
Nature Neuroscience 12 (2009) 1308–1316.
date_created: 2018-12-11T11:54:04Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2021-01-12T06:53:16Z
day: '01'
doi: 10.1038/nn.2389
extern: 1
intvolume: ' 12'
issue: '10'
month: '10'
page: 1308 - 1316
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '5311'
quality_controlled: 0
status: public
title: Approach sensitivity in the retina processed by a multifunctional neural circuit
type: journal_article
volume: 12
year: '2009'
...
---
_id: '844'
abstract:
- lang: eng
text: Mutation rate varies greatly between nucleotide sites of the human genome
and depends both on the global genomic location and the local sequence context
of a site. In particular, CpG context elevates the mutation rate by an order of
magnitude. Mutations also vary widely in their effect on the molecular function,
phenotype, and fitness. Independence of the probability of occurrence of a new
mutation's effect has been a fundamental premise in genetics. However, highly
mutable contexts may be preserved by negative selection at important sites but
destroyed by mutation at sites under no selection. Thus, there may be a positive
correlation between the rate of mutations at a nucleotide site and the magnitude
of their effect on fitness. We studied the impact of CpG context on the rate of
human-chimpanzee divergence and on intrahuman nucleotide diversity at non-synonymous
coding sites. We compared nucleotides that occupy identical positions within codons
of identical amino acids and only differ by being within versus outside CpG context.
Nucleotides within CpG context are under a stronger negative selection, as revealed
by their lower, proportionally to the mutation rate, rate of evolution and nucleotide
diversity. In particular, the probability of fixation of a non-synonymous transition
at a CpG site is two times lower than at a CpG site. Thus, sites with different
mutation rates are not necessarily selectively equivalent. This suggests that
the mutation rate may complement sequence conservation as a characteristic predictive
of functional importance of nucleotide sites.
acknowledgement: This work was supported in part by NIH grants R01 GM078598 and U54
LM008748.
author:
- first_name: Steffen
full_name: Schmidt, Steffen
last_name: Schmidt
- first_name: Anna
full_name: Gerasimova, Anna
last_name: Gerasimova
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Ivan
full_name: Adzuhbei, Ivan A
last_name: Adzuhbei
- first_name: Alexey
full_name: Kondrashov, Alexey S
last_name: Kondrashov
- first_name: Shamil
full_name: Sunyaev, Shamil R
last_name: Sunyaev
citation:
ama: Schmidt S, Gerasimova A, Kondrashov F, Adzuhbei I, Kondrashov A, Sunyaev S.
Hypermutable non-synonymous sites are under stronger negative selection. PLoS
Genetics. 2008;4(11). doi:10.1371/journal.pgen.1000281
apa: Schmidt, S., Gerasimova, A., Kondrashov, F., Adzuhbei, I., Kondrashov, A.,
& Sunyaev, S. (2008). Hypermutable non-synonymous sites are under stronger
negative selection. PLoS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1000281
chicago: Schmidt, Steffen, Anna Gerasimova, Fyodor Kondrashov, Ivan Adzuhbei, Alexey
Kondrashov, and Shamil Sunyaev. “Hypermutable Non-Synonymous Sites Are under Stronger
Negative Selection.” PLoS Genetics. Public Library of Science, 2008. https://doi.org/10.1371/journal.pgen.1000281.
ieee: S. Schmidt, A. Gerasimova, F. Kondrashov, I. Adzuhbei, A. Kondrashov, and
S. Sunyaev, “Hypermutable non-synonymous sites are under stronger negative selection,”
PLoS Genetics, vol. 4, no. 11. Public Library of Science, 2008.
ista: Schmidt S, Gerasimova A, Kondrashov F, Adzuhbei I, Kondrashov A, Sunyaev S.
2008. Hypermutable non-synonymous sites are under stronger negative selection.
PLoS Genetics. 4(11).
mla: Schmidt, Steffen, et al. “Hypermutable Non-Synonymous Sites Are under Stronger
Negative Selection.” PLoS Genetics, vol. 4, no. 11, Public Library of Science,
2008, doi:10.1371/journal.pgen.1000281.
short: S. Schmidt, A. Gerasimova, F. Kondrashov, I. Adzuhbei, A. Kondrashov, S.
Sunyaev, PLoS Genetics 4 (2008).
date_created: 2018-12-11T11:48:48Z
date_published: 2008-11-01T00:00:00Z
date_updated: 2021-01-12T08:19:16Z
day: '01'
doi: 10.1371/journal.pgen.1000281
extern: 1
intvolume: ' 4'
issue: '11'
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
publication: PLoS Genetics
publication_status: published
publisher: Public Library of Science
publist_id: '6800'
quality_controlled: 0
status: public
title: Hypermutable non-synonymous sites are under stronger negative selection
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 4
year: '2008'
...
---
_id: '8480'
abstract:
- lang: eng
text: The KIX domain of the transcription co-activator CBP is a three-helix bundle
protein that folds via rapid accumulation of an intermediate state, followed by
a slower folding phase. Recent NMR relaxation dispersion studies revealed the
presence of a low-populated (excited) state of KIX that exists in equilibrium
with the natively folded form under non-denaturing conditions, and likely represents
the equilibrium analog of the folding intermediate. Here, we combine amide hydrogen/deuterium
exchange measurements using rapid NMR data acquisition techniques with backbone
15N and 13C relaxation dispersion experiments to further investigate the equilibrium
folding of the KIX domain. Residual structure within the folding intermediate
is detected by both methods, and their combination enables reliable quantification
of the amount of persistent residual structure. Three well-defined folding subunits
are found, which display variable stability and correspond closely to the individual
helices in the native state. While two of the three helices (α2 and α3) are partially
formed in the folding intermediate (to ∼ 50% and ∼ 80%, respectively, at 20 °C),
the third helix is disordered. The observed helical content within the excited
state exceeds the helical propensities predicted for the corresponding peptide
regions, suggesting that the two helices are weakly mutually stabilized, while
methyl 13C relaxation dispersion data indicate that a defined packing arrangement
is unlikely. Temperature-dependent experiments reveal that the largest enthalpy
and entropy changes along the folding reaction occur during the final transition
from the intermediate to the native state. Our experimental data are consistent
with a folding mechanism where helices α2 and α3 form rapidly, although to different
extents, while helix α1 consolidates only as folding proceeds to complete the
native state-structure.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
- first_name: Robert
full_name: Konrat, Robert
last_name: Konrat
- first_name: Martin
full_name: Tollinger, Martin
last_name: Tollinger
citation:
ama: 'Schanda P, Brutscher B, Konrat R, Tollinger M. Folding of the KIX domain:
Characterization of the equilibrium analog of a folding intermediate using 15N/13C
relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy. Journal
of Molecular Biology. 2008;380(4):726-741. doi:10.1016/j.jmb.2008.05.040'
apa: 'Schanda, P., Brutscher, B., Konrat, R., & Tollinger, M. (2008). Folding
of the KIX domain: Characterization of the equilibrium analog of a folding intermediate
using 15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy.
Journal of Molecular Biology. Elsevier. https://doi.org/10.1016/j.jmb.2008.05.040'
chicago: 'Schanda, Paul, Bernhard Brutscher, Robert Konrat, and Martin Tollinger.
“Folding of the KIX Domain: Characterization of the Equilibrium Analog of a Folding
Intermediate Using 15N/13C Relaxation Dispersion and Fast 1H/2H Amide Exchange
NMR Spectroscopy.” Journal of Molecular Biology. Elsevier, 2008. https://doi.org/10.1016/j.jmb.2008.05.040.'
ieee: 'P. Schanda, B. Brutscher, R. Konrat, and M. Tollinger, “Folding of the KIX
domain: Characterization of the equilibrium analog of a folding intermediate using
15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy,”
Journal of Molecular Biology, vol. 380, no. 4. Elsevier, pp. 726–741, 2008.'
ista: 'Schanda P, Brutscher B, Konrat R, Tollinger M. 2008. Folding of the KIX domain:
Characterization of the equilibrium analog of a folding intermediate using 15N/13C
relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy. Journal
of Molecular Biology. 380(4), 726–741.'
mla: 'Schanda, Paul, et al. “Folding of the KIX Domain: Characterization of the
Equilibrium Analog of a Folding Intermediate Using 15N/13C Relaxation Dispersion
and Fast 1H/2H Amide Exchange NMR Spectroscopy.” Journal of Molecular Biology,
vol. 380, no. 4, Elsevier, 2008, pp. 726–41, doi:10.1016/j.jmb.2008.05.040.'
short: P. Schanda, B. Brutscher, R. Konrat, M. Tollinger, Journal of Molecular Biology
380 (2008) 726–741.
date_created: 2020-09-18T10:12:29Z
date_published: 2008-07-18T00:00:00Z
date_updated: 2021-01-12T08:19:34Z
day: '18'
doi: 10.1016/j.jmb.2008.05.040
extern: '1'
intvolume: ' 380'
issue: '4'
keyword:
- Molecular Biology
language:
- iso: eng
month: '07'
oa_version: None
page: 726-741
publication: Journal of Molecular Biology
publication_identifier:
issn:
- 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Folding of the KIX domain: Characterization of the equilibrium analog of a
folding intermediate using 15N/13C relaxation dispersion and fast 1H/2H amide exchange
NMR spectroscopy'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 380
year: '2008'
...
---
_id: '8481'
abstract:
- lang: eng
text: 'The copK gene is localized on the pMOL30 plasmid of Cupriavidus metallidurans
CH34 within the complex cop cluster of genes, for which 21 genes have been identified.
The expression of the corresponding periplasmic CopK protein is strongly upregulated
in the presence of copper, leading to a high periplasmic accumulation. The structure
and metal-binding properties of CopK were investigated by NMR and mass spectrometry.
The protein is dimeric in the apo state with a dissociation constant in the range
of 10- 5 M estimated from analytical ultracentrifugation. Mass spectrometry revealed
that CopK has two high-affinity Cu(I)-binding sites per monomer with different
Cu(I) affinities. Binding of Cu(II) was observed but appeared to be non-specific.
The solution structure of apo-CopK revealed an all-β fold formed of two β-sheets
in perpendicular orientation with an unstructured C-terminal tail. The dimer interface
is formed by the surface of the C-terminal β-sheet. Binding of the first Cu(I)-ion
induces a major structural modification involving dissociation of the dimeric
apo-protein. Backbone chemical shifts determined for the 1Cu(I)-bound form confirm
the conservation of the N-terminal β-sheet, while the last strand of the C-terminal
sheet appears in slow conformational exchange. We hypothesize that the partial
disruption of the C-terminal β-sheet is related to dimer dissociation. NH-exchange
data acquired on the apo-protein are consistent with a lower thermodynamic stability
of the C-terminal sheet. CopK contains seven methionine residues, five of which
appear highly conserved. Chemical shift data suggest implication of two or three
methionines (Met54, Met38, Met28) in the first Cu(I) site. Addition of a second
Cu(I) ion further increases protein plasticity. Comparison of the structural and
metal-binding properties of CopK with other periplasmic copper-binding proteins
reveals two conserved features within these functionally related proteins: the
all-β fold and the methionine-rich Cu(I)-binding site.'
article_processing_charge: No
article_type: original
author:
- first_name: Beate
full_name: Bersch, Beate
last_name: Bersch
- first_name: Adrien
full_name: Favier, Adrien
last_name: Favier
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Sébastien
full_name: van Aelst, Sébastien
last_name: van Aelst
- first_name: Tatiana
full_name: Vallaeys, Tatiana
last_name: Vallaeys
- first_name: Jacques
full_name: Covès, Jacques
last_name: Covès
- first_name: Max
full_name: Mergeay, Max
last_name: Mergeay
- first_name: Ruddy
full_name: Wattiez, Ruddy
last_name: Wattiez
citation:
ama: Bersch B, Favier A, Schanda P, et al. Molecular structure and metal-binding
properties of the periplasmic CopK protein expressed in Cupriavidus metallidurans
CH34 during copper challenge. Journal of Molecular Biology. 2008;380(2):386-403.
doi:10.1016/j.jmb.2008.05.017
apa: Bersch, B., Favier, A., Schanda, P., van Aelst, S., Vallaeys, T., Covès, J.,
… Wattiez, R. (2008). Molecular structure and metal-binding properties of the
periplasmic CopK protein expressed in Cupriavidus metallidurans CH34 during copper
challenge. Journal of Molecular Biology. Elsevier. https://doi.org/10.1016/j.jmb.2008.05.017
chicago: Bersch, Beate, Adrien Favier, Paul Schanda, Sébastien van Aelst, Tatiana
Vallaeys, Jacques Covès, Max Mergeay, and Ruddy Wattiez. “Molecular Structure
and Metal-Binding Properties of the Periplasmic CopK Protein Expressed in Cupriavidus
Metallidurans CH34 during Copper Challenge.” Journal of Molecular Biology.
Elsevier, 2008. https://doi.org/10.1016/j.jmb.2008.05.017.
ieee: B. Bersch et al., “Molecular structure and metal-binding properties
of the periplasmic CopK protein expressed in Cupriavidus metallidurans CH34 during
copper challenge,” Journal of Molecular Biology, vol. 380, no. 2. Elsevier,
pp. 386–403, 2008.
ista: Bersch B, Favier A, Schanda P, van Aelst S, Vallaeys T, Covès J, Mergeay M,
Wattiez R. 2008. Molecular structure and metal-binding properties of the periplasmic
CopK protein expressed in Cupriavidus metallidurans CH34 during copper challenge.
Journal of Molecular Biology. 380(2), 386–403.
mla: Bersch, Beate, et al. “Molecular Structure and Metal-Binding Properties of
the Periplasmic CopK Protein Expressed in Cupriavidus Metallidurans CH34 during
Copper Challenge.” Journal of Molecular Biology, vol. 380, no. 2, Elsevier,
2008, pp. 386–403, doi:10.1016/j.jmb.2008.05.017.
short: B. Bersch, A. Favier, P. Schanda, S. van Aelst, T. Vallaeys, J. Covès, M.
Mergeay, R. Wattiez, Journal of Molecular Biology 380 (2008) 386–403.
date_created: 2020-09-18T10:12:37Z
date_published: 2008-07-04T00:00:00Z
date_updated: 2021-01-12T08:19:34Z
day: '04'
doi: 10.1016/j.jmb.2008.05.017
extern: '1'
intvolume: ' 380'
issue: '2'
keyword:
- Molecular Biology
language:
- iso: eng
month: '07'
oa_version: None
page: 386-403
publication: Journal of Molecular Biology
publication_identifier:
issn:
- 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Molecular structure and metal-binding properties of the periplasmic CopK protein
expressed in Cupriavidus metallidurans CH34 during copper challenge
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 380
year: '2008'
...
---
_id: '8482'
abstract:
- lang: eng
text: The SOFAST-HMQC experiment [P. Schanda, B. Brutscher, Very fast two-dimensional
NMR spectroscopy for real-time investigation of dynamic events in proteins on
the time scale of seconds, J. Am. Chem. Soc. 127 (2005) 8014–8015] allows recording
two-dimensional correlation spectra of macromolecules such as proteins in only
a few seconds acquisition time. To achieve the highest possible sensitivity, SOFAST-HMQC
experiments are preferably performed on high-field NMR spectrometers equipped
with cryogenically cooled probes. The duty cycle of over 80% in fast-pulsing SOFAST-HMQC
experiments, however, may cause problems when using a cryogenic probe. Here we
introduce SE-IPAP-SOFAST-HMQC, a new pulse sequence that provides comparable sensitivity
to standard SOFAST-HMQC, while avoiding heteronuclear decoupling during 1H detection,
and thus significantly reducing the radiofrequency load of the probe during the
experiment. The experiment is also attractive for fast and sensitive measurement
of heteronuclear one-bond spin coupling constants.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Thomas
full_name: Kern, Thomas
last_name: Kern
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Kern T, Schanda P, Brutscher B. Sensitivity-enhanced IPAP-SOFAST-HMQC for fast-pulsing
2D NMR with reduced radiofrequency load. Journal of Magnetic Resonance.
2008;190(2):333-338. doi:10.1016/j.jmr.2007.11.015
apa: Kern, T., Schanda, P., & Brutscher, B. (2008). Sensitivity-enhanced IPAP-SOFAST-HMQC
for fast-pulsing 2D NMR with reduced radiofrequency load. Journal of Magnetic
Resonance. Elsevier. https://doi.org/10.1016/j.jmr.2007.11.015
chicago: Kern, Thomas, Paul Schanda, and Bernhard Brutscher. “Sensitivity-Enhanced
IPAP-SOFAST-HMQC for Fast-Pulsing 2D NMR with Reduced Radiofrequency Load.” Journal
of Magnetic Resonance. Elsevier, 2008. https://doi.org/10.1016/j.jmr.2007.11.015.
ieee: T. Kern, P. Schanda, and B. Brutscher, “Sensitivity-enhanced IPAP-SOFAST-HMQC
for fast-pulsing 2D NMR with reduced radiofrequency load,” Journal of Magnetic
Resonance, vol. 190, no. 2. Elsevier, pp. 333–338, 2008.
ista: Kern T, Schanda P, Brutscher B. 2008. Sensitivity-enhanced IPAP-SOFAST-HMQC
for fast-pulsing 2D NMR with reduced radiofrequency load. Journal of Magnetic
Resonance. 190(2), 333–338.
mla: Kern, Thomas, et al. “Sensitivity-Enhanced IPAP-SOFAST-HMQC for Fast-Pulsing
2D NMR with Reduced Radiofrequency Load.” Journal of Magnetic Resonance,
vol. 190, no. 2, Elsevier, 2008, pp. 333–38, doi:10.1016/j.jmr.2007.11.015.
short: T. Kern, P. Schanda, B. Brutscher, Journal of Magnetic Resonance 190 (2008)
333–338.
date_created: 2020-09-18T10:12:46Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T08:19:35Z
day: '01'
doi: 10.1016/j.jmr.2007.11.015
extern: '1'
intvolume: ' 190'
issue: '2'
keyword:
- Nuclear and High Energy Physics
- Biophysics
- Biochemistry
- Condensed Matter Physics
language:
- iso: eng
month: '02'
oa_version: None
page: 333-338
publication: Journal of Magnetic Resonance
publication_identifier:
issn:
- 1090-7807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Sensitivity-enhanced IPAP-SOFAST-HMQC for fast-pulsing 2D NMR with reduced
radiofrequency load
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 190
year: '2008'
...
---
_id: '8509'
abstract:
- lang: eng
text: The goal of this paper is to present to nonspecialists what is perhaps the
simplest possible geometrical picture explaining the mechanism of Arnold diffusion.
We choose to speak of a specific model—that of geometric rays in a periodic optical
medium. This model is equivalent to that of a particle in a periodic potential
in ${\mathbb R}^{n}$ with energy prescribed and to the geodesic flow in a Riemannian
metric on ${\mathbb R}^{n} $.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Mark
full_name: Levi, Mark
last_name: Levi
citation:
ama: Kaloshin V, Levi M. Geometry of Arnold diffusion. SIAM Review. 2008;50(4):702-720.
doi:10.1137/070703235
apa: Kaloshin, V., & Levi, M. (2008). Geometry of Arnold diffusion. SIAM
Review. Society for Industrial & Applied Mathematics. https://doi.org/10.1137/070703235
chicago: Kaloshin, Vadim, and Mark Levi. “Geometry of Arnold Diffusion.” SIAM
Review. Society for Industrial & Applied Mathematics, 2008. https://doi.org/10.1137/070703235.
ieee: V. Kaloshin and M. Levi, “Geometry of Arnold diffusion,” SIAM Review,
vol. 50, no. 4. Society for Industrial & Applied Mathematics, pp. 702–720,
2008.
ista: Kaloshin V, Levi M. 2008. Geometry of Arnold diffusion. SIAM Review. 50(4),
702–720.
mla: Kaloshin, Vadim, and Mark Levi. “Geometry of Arnold Diffusion.” SIAM Review,
vol. 50, no. 4, Society for Industrial & Applied Mathematics, 2008, pp. 702–20,
doi:10.1137/070703235.
short: V. Kaloshin, M. Levi, SIAM Review 50 (2008) 702–720.
date_created: 2020-09-18T10:48:12Z
date_published: 2008-11-05T00:00:00Z
date_updated: 2021-01-12T08:19:46Z
day: '05'
doi: 10.1137/070703235
extern: '1'
intvolume: ' 50'
issue: '4'
keyword:
- Theoretical Computer Science
- Applied Mathematics
- Computational Mathematics
language:
- iso: eng
month: '11'
oa_version: None
page: 702-720
publication: SIAM Review
publication_identifier:
issn:
- 0036-1445
- 1095-7200
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
status: public
title: Geometry of Arnold diffusion
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2008'
...
---
_id: '8510'
abstract:
- lang: eng
text: In this paper, using the ideas of Bessi and Mather, we present a simple mechanical
system exhibiting Arnold diffusion. This system of a particle in a small periodic
potential can be also interpreted as ray propagation in a periodic optical medium
with a near-constant index of refraction. Arnold diffusion in this context manifests
itself as an arbitrary finite change of direction for nearly constant index of
refraction.
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Mark
full_name: Levi, Mark
last_name: Levi
citation:
ama: Kaloshin V, Levi M. An example of Arnold diffusion for near-integrable Hamiltonians.
Bulletin of the American Mathematical Society. 2008;45(3):409-427. doi:10.1090/s0273-0979-08-01211-1
apa: Kaloshin, V., & Levi, M. (2008). An example of Arnold diffusion for near-integrable
Hamiltonians. Bulletin of the American Mathematical Society. American Mathematical
Society. https://doi.org/10.1090/s0273-0979-08-01211-1
chicago: Kaloshin, Vadim, and Mark Levi. “An Example of Arnold Diffusion for Near-Integrable
Hamiltonians.” Bulletin of the American Mathematical Society. American
Mathematical Society, 2008. https://doi.org/10.1090/s0273-0979-08-01211-1.
ieee: V. Kaloshin and M. Levi, “An example of Arnold diffusion for near-integrable
Hamiltonians,” Bulletin of the American Mathematical Society, vol. 45,
no. 3. American Mathematical Society, pp. 409–427, 2008.
ista: Kaloshin V, Levi M. 2008. An example of Arnold diffusion for near-integrable
Hamiltonians. Bulletin of the American Mathematical Society. 45(3), 409–427.
mla: Kaloshin, Vadim, and Mark Levi. “An Example of Arnold Diffusion for Near-Integrable
Hamiltonians.” Bulletin of the American Mathematical Society, vol. 45,
no. 3, American Mathematical Society, 2008, pp. 409–27, doi:10.1090/s0273-0979-08-01211-1.
short: V. Kaloshin, M. Levi, Bulletin of the American Mathematical Society 45 (2008)
409–427.
date_created: 2020-09-18T10:48:20Z
date_published: 2008-07-01T00:00:00Z
date_updated: 2021-01-12T08:19:47Z
day: '01'
doi: 10.1090/s0273-0979-08-01211-1
extern: '1'
intvolume: ' 45'
issue: '3'
keyword:
- Applied Mathematics
- General Mathematics
language:
- iso: eng
month: '07'
oa_version: None
page: 409-427
publication: Bulletin of the American Mathematical Society
publication_identifier:
issn:
- 0273-0979
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: An example of Arnold diffusion for near-integrable Hamiltonians
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2008'
...
---
_id: '895'
abstract:
- lang: eng
text: Background. The arginine vasopressin V1a receptor (V1aR) modulates social
cognition and behavior in a wide variety of species. Variation in a repetitive
microsatellite element in the 5′ flanking region of the V1aR gene (AVPR1A) in
rodents has been associated with variation in brain V1aR expression and in social
behavior. In humans, the 5′ flanking region of AVPR1A contains a tandem duplication
of two ∼350 bp, microsatellite-containing elements located approximately 3.5 kb
upstream of the transcription start site. The first block, referred to as DupA,
contains a polymorphic (GT) 25microsatellite; the second block, DupB, has a complex
(CT) 4-(TT)-(CT)8-(GT)24polymorphic motif, known as RS3. Polymorphisms in RS3
have been associated with variation in sociobehavioral traits in humans, including
autism spectrum disorders. Thus, evolution of these regions may have contributed
to variation in social behavior in primates. We examined the structure of these
regions in six ape, six monkey, and one prosimian species. Results. Both tandem
repeat blocks are present upstream of the AVPR1A coding region in five of the
ape species we investigated, while monkeys have only one copy of this region.
As in humans, the microsatellites within DupA and DupB are polymorphic in many
primate species. Furthermore, both single (lacking DupB) and duplicated alleles
(containing both DupA and DupB) are present in chimpanzee (Pan troglodytes) populations
with allele frequencies of 0.795 and 0.205 for the single and duplicated alleles,
respectively, based on the analysis of 47 wild-caught individuals. Finally, a
phylogenetic reconstruction suggests two alternate evolutionary histories for
this locus. Conclusion. There is no obvious relationship between the presence
of the RS3 duplication and social organization in primates. However, polymorphisms
identified in some species may be useful in future genetic association studies.
In particular, the presence of both single and duplicated alleles in chimpanzees
provides a unique opportunity to assess the functional role of this duplication
in contributing to variation in social behavior in primates. While our initial
studies show no signs of directional selection on this locus in chimps, pharmacological
and genetic association studies support a potential role for this region in influencing
V1aR expression and social behavior.
acknowledgement: |
We thank the caretakers at Zoo Atlanta and Yerkes National Primate Center for help with procuring specimens. Additional DNA samples were supplied by Bill Hopkins, Emory University (chimpanzee), Allyson Bennet, Wake Forest University (chimpanzee, rhesus macaque, bonnet macaque), Mar Sanchez, Emory University (rhesus macaque), and Anne Yoder, Duke University (galago). Susan Lambeth, M.D. Anderson Cancer Center, and Katie Chace, Yerkes National Primate Center, helped provide records regarding the origins of wild born chimps at these centers. We would like to thank Dr Lisa McGraw and two anonymous reviewers for their com- ments on this manuscript. This work was supported by NSF IBN-9876754, NIH RR00165, NIMH56897 (LJY), MH64692 (LJY) and a Howard Hughes Predoctoral Fellowship (ZRD).
author:
- first_name: Zoe
full_name: Donaldson, Zoe R
last_name: Donaldson
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Andrea
full_name: Putnam, Andrea S
last_name: Putnam
- first_name: Yaohui
full_name: Bai, Yaohui
last_name: Bai
- first_name: Tara
full_name: Stoinski, Tara S
last_name: Stoinski
- first_name: Elizabeth
full_name: Hammock, Elizabeth A
last_name: Hammock
- first_name: Larry
full_name: Young, Larry
last_name: Young
citation:
ama: Donaldson Z, Kondrashov F, Putnam A, et al. Evolution of a behavior-linked
microsatellite-containing element in the 5′ flanking region of the primate AVPR1A
gene. BMC Evolutionary Biology. 2008;8(1). doi:10.1186/1471-2148-8-180
apa: Donaldson, Z., Kondrashov, F., Putnam, A., Bai, Y., Stoinski, T., Hammock,
E., & Young, L. (2008). Evolution of a behavior-linked microsatellite-containing
element in the 5′ flanking region of the primate AVPR1A gene. BMC Evolutionary
Biology. BioMed Central. https://doi.org/10.1186/1471-2148-8-180
chicago: Donaldson, Zoe, Fyodor Kondrashov, Andrea Putnam, Yaohui Bai, Tara Stoinski,
Elizabeth Hammock, and Larry Young. “Evolution of a Behavior-Linked Microsatellite-Containing
Element in the 5′ Flanking Region of the Primate AVPR1A Gene.” BMC Evolutionary
Biology. BioMed Central, 2008. https://doi.org/10.1186/1471-2148-8-180.
ieee: Z. Donaldson et al., “Evolution of a behavior-linked microsatellite-containing
element in the 5′ flanking region of the primate AVPR1A gene,” BMC Evolutionary
Biology, vol. 8, no. 1. BioMed Central, 2008.
ista: Donaldson Z, Kondrashov F, Putnam A, Bai Y, Stoinski T, Hammock E, Young L.
2008. Evolution of a behavior-linked microsatellite-containing element in the
5′ flanking region of the primate AVPR1A gene. BMC Evolutionary Biology. 8(1).
mla: Donaldson, Zoe, et al. “Evolution of a Behavior-Linked Microsatellite-Containing
Element in the 5′ Flanking Region of the Primate AVPR1A Gene.” BMC Evolutionary
Biology, vol. 8, no. 1, BioMed Central, 2008, doi:10.1186/1471-2148-8-180.
short: Z. Donaldson, F. Kondrashov, A. Putnam, Y. Bai, T. Stoinski, E. Hammock,
L. Young, BMC Evolutionary Biology 8 (2008).
date_created: 2018-12-11T11:49:04Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T08:21:29Z
day: '01'
doi: 10.1186/1471-2148-8-180
extern: 1
intvolume: ' 8'
issue: '1'
month: '01'
publication: BMC Evolutionary Biology
publication_status: published
publisher: BioMed Central
publist_id: '6753'
quality_controlled: 0
status: public
title: Evolution of a behavior-linked microsatellite-containing element in the 5′
flanking region of the primate AVPR1A gene
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 8
year: '2008'
...
---
_id: '907'
abstract:
- lang: eng
text: The most common form of protein-coding gene overlap in eukaryotes is a simple
nested structure, whereby one gene is embedded in an intron of another. Analysis
of nested protein-coding genes in vertebrates, fruit flies and nematodes revealed
substantially higher rates of evolutionary gains than losses. The accumulation
of nested gene structures could not be attributed to any obvious functional relationships
between the genes involved and represents an increase of the organizational complexity
of animal genomes via a neutral process.
author:
- first_name: Raquel
full_name: Assis, Raquel
last_name: Assis
- first_name: Alexey
full_name: Kondrashov, Alexey S
last_name: Kondrashov
- first_name: Eugene
full_name: Koonin, Eugene V
last_name: Koonin
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Assis R, Kondrashov A, Koonin E, Kondrashov F. Nested genes and increasing
organizational complexity of metazoan genomes. Trends in Genetics. 2008;24(10):475-478.
doi:10.1016/j.tig.2008.08.003
apa: Assis, R., Kondrashov, A., Koonin, E., & Kondrashov, F. (2008). Nested
genes and increasing organizational complexity of metazoan genomes. Trends
in Genetics. Elsevier. https://doi.org/10.1016/j.tig.2008.08.003
chicago: Assis, Raquel, Alexey Kondrashov, Eugene Koonin, and Fyodor Kondrashov.
“Nested Genes and Increasing Organizational Complexity of Metazoan Genomes.” Trends
in Genetics. Elsevier, 2008. https://doi.org/10.1016/j.tig.2008.08.003.
ieee: R. Assis, A. Kondrashov, E. Koonin, and F. Kondrashov, “Nested genes and increasing
organizational complexity of metazoan genomes,” Trends in Genetics, vol.
24, no. 10. Elsevier, pp. 475–478, 2008.
ista: Assis R, Kondrashov A, Koonin E, Kondrashov F. 2008. Nested genes and increasing
organizational complexity of metazoan genomes. Trends in Genetics. 24(10), 475–478.
mla: Assis, Raquel, et al. “Nested Genes and Increasing Organizational Complexity
of Metazoan Genomes.” Trends in Genetics, vol. 24, no. 10, Elsevier, 2008,
pp. 475–78, doi:10.1016/j.tig.2008.08.003.
short: R. Assis, A. Kondrashov, E. Koonin, F. Kondrashov, Trends in Genetics 24
(2008) 475–478.
date_created: 2018-12-11T11:49:08Z
date_published: 2008-10-01T00:00:00Z
date_updated: 2021-01-12T08:21:49Z
day: '01'
doi: 10.1016/j.tig.2008.08.003
extern: 1
intvolume: ' 24'
issue: '10'
month: '10'
page: 475 - 478
publication: Trends in Genetics
publication_status: published
publisher: Elsevier
publist_id: '6743'
quality_controlled: 0
status: public
title: Nested genes and increasing organizational complexity of metazoan genomes
type: journal_article
volume: 24
year: '2008'
...
---
_id: '7320'
abstract:
- lang: eng
text: A comparative, experimental diffusivity study of gas diffusion layer (GDL)
materials for polymer electrolyte fuel cells (PEFC) is presented for the first
time. The GDL plays an important role for electrochemical losses due to gas transport
limitations at high current densities. Characterization and optimization of these
layers is therefore essential to improve power density. A recently developed method
which allows for fast diffusimetry is applied and data compared to the literature
values. Measurements are made as a function of direction and compression and the
effect of different binder structures and hydrophobic treatments on effective
diffusivities are discussed. A better understanding of the results is gained by
including novel GDL cross-section images and a meaningful unit cell model for
the interpretation of the data. The diffusivity data is valuable for GDL manufacturers
and future PEFC models. The study reveals that a binder–fiber ratio larger than
50% has a negative impact on the effective diffusion properties. The hydrophobic
treatment which is necessary to improve the water management can impede diffusion
and thus reduce the power density. Furthermore binder has an isotropic effect
while compression pronounces the in-plane orientation of the fibers.
article_processing_charge: No
article_type: original
author:
- first_name: Reto
full_name: Flückiger, Reto
last_name: Flückiger
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Denis
full_name: Kramer, Denis
last_name: Kramer
- first_name: Alexander
full_name: Wokaun, Alexander
last_name: Wokaun
- first_name: Günther G.
full_name: Scherer, Günther G.
last_name: Scherer
- first_name: Felix N.
full_name: Büchi, Felix N.
last_name: Büchi
citation:
ama: Flückiger R, Freunberger SA, Kramer D, Wokaun A, Scherer GG, Büchi FN. Anisotropic,
effective diffusivity of porous gas diffusion layer materials for PEFC. Electrochimica
Acta. 2008;54(2):551-559. doi:10.1016/j.electacta.2008.07.034
apa: Flückiger, R., Freunberger, S. A., Kramer, D., Wokaun, A., Scherer, G. G.,
& Büchi, F. N. (2008). Anisotropic, effective diffusivity of porous gas diffusion
layer materials for PEFC. Electrochimica Acta. Elsevier. https://doi.org/10.1016/j.electacta.2008.07.034
chicago: Flückiger, Reto, Stefan Alexander Freunberger, Denis Kramer, Alexander
Wokaun, Günther G. Scherer, and Felix N. Büchi. “Anisotropic, Effective Diffusivity
of Porous Gas Diffusion Layer Materials for PEFC.” Electrochimica Acta.
Elsevier, 2008. https://doi.org/10.1016/j.electacta.2008.07.034.
ieee: R. Flückiger, S. A. Freunberger, D. Kramer, A. Wokaun, G. G. Scherer, and
F. N. Büchi, “Anisotropic, effective diffusivity of porous gas diffusion layer
materials for PEFC,” Electrochimica Acta, vol. 54, no. 2. Elsevier, pp.
551–559, 2008.
ista: Flückiger R, Freunberger SA, Kramer D, Wokaun A, Scherer GG, Büchi FN. 2008.
Anisotropic, effective diffusivity of porous gas diffusion layer materials for
PEFC. Electrochimica Acta. 54(2), 551–559.
mla: Flückiger, Reto, et al. “Anisotropic, Effective Diffusivity of Porous Gas Diffusion
Layer Materials for PEFC.” Electrochimica Acta, vol. 54, no. 2, Elsevier,
2008, pp. 551–59, doi:10.1016/j.electacta.2008.07.034.
short: R. Flückiger, S.A. Freunberger, D. Kramer, A. Wokaun, G.G. Scherer, F.N.
Büchi, Electrochimica Acta 54 (2008) 551–559.
date_created: 2020-01-15T12:21:36Z
date_published: 2008-12-30T00:00:00Z
date_updated: 2021-01-12T08:13:02Z
day: '30'
doi: 10.1016/j.electacta.2008.07.034
extern: '1'
intvolume: ' 54'
issue: '2'
language:
- iso: eng
month: '12'
oa_version: None
page: 551-559
publication: Electrochimica Acta
publication_identifier:
issn:
- 0013-4686
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Anisotropic, effective diffusivity of porous gas diffusion layer materials
for PEFC
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2008'
...
---
_id: '7321'
abstract:
- lang: eng
text: Cell interaction phenomena in polymer electrolyte fuel cell stacks that arise
from imbalance between adjacent cells are investigated in detail experimentally
and theoretically. A specialized two-cell stack with advanced localized diagnostics
was developed and used to analyze the mechanism and effect of cell-to-cell coupling
as a result of operationally relevant variations in reactant feed flow. Contributions
to overall and local voltage changes with respect to uniformly operated cells
are scrutinized. Unequal operation of the cells causes in-plane current in the
bipolar plate to redistribute current and result in inhomogeneous polarization.
Both increasing and decreasing polarization along the air-flow path reduces cell
power as compared to isopotential operation. A two-dimensional model based on
a commercial computational fluid dynamics code is used to back and extend the
experimental results to more general cases. Furthermore, the experimental setup
presented allowed for the first time to perform simultaneous localized electrochemical
impedance spectroscopy beyond the single-cell level. The mechanism of mutual cell
interaction on local and integral spectra is revealed. Results show that virtually
identical operation of the cells is essential to obtain meaningful integral spectra.
article_number: B704
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Ingo A.
full_name: Schneider, Ingo A.
last_name: Schneider
- first_name: Pang-Chieh
full_name: Sui, Pang-Chieh
last_name: Sui
- first_name: Alexander
full_name: Wokaun, Alexander
last_name: Wokaun
- first_name: Nedjib
full_name: Djilali, Nedjib
last_name: Djilali
- first_name: Felix N.
full_name: Büchi, Felix N.
last_name: Büchi
citation:
ama: Freunberger SA, Schneider IA, Sui P-C, Wokaun A, Djilali N, Büchi FN. Cell
interaction phenomena in polymer electrolyte fuel cell stacks. Journal of The
Electrochemical Society. 2008;155(7). doi:10.1149/1.2913095
apa: Freunberger, S. A., Schneider, I. A., Sui, P.-C., Wokaun, A., Djilali, N.,
& Büchi, F. N. (2008). Cell interaction phenomena in polymer electrolyte
fuel cell stacks. Journal of The Electrochemical Society. The Electrochemical
Society. https://doi.org/10.1149/1.2913095
chicago: Freunberger, Stefan Alexander, Ingo A. Schneider, Pang-Chieh Sui, Alexander
Wokaun, Nedjib Djilali, and Felix N. Büchi. “Cell Interaction Phenomena in Polymer
Electrolyte Fuel Cell Stacks.” Journal of The Electrochemical Society.
The Electrochemical Society, 2008. https://doi.org/10.1149/1.2913095.
ieee: S. A. Freunberger, I. A. Schneider, P.-C. Sui, A. Wokaun, N. Djilali, and
F. N. Büchi, “Cell interaction phenomena in polymer electrolyte fuel cell stacks,”
Journal of The Electrochemical Society, vol. 155, no. 7. The Electrochemical
Society, 2008.
ista: Freunberger SA, Schneider IA, Sui P-C, Wokaun A, Djilali N, Büchi FN. 2008.
Cell interaction phenomena in polymer electrolyte fuel cell stacks. Journal of
The Electrochemical Society. 155(7), B704.
mla: Freunberger, Stefan Alexander, et al. “Cell Interaction Phenomena in Polymer
Electrolyte Fuel Cell Stacks.” Journal of The Electrochemical Society,
vol. 155, no. 7, B704, The Electrochemical Society, 2008, doi:10.1149/1.2913095.
short: S.A. Freunberger, I.A. Schneider, P.-C. Sui, A. Wokaun, N. Djilali, F.N.
Büchi, Journal of The Electrochemical Society 155 (2008).
date_created: 2020-01-15T12:21:47Z
date_published: 2008-05-08T00:00:00Z
date_updated: 2021-01-12T08:13:03Z
day: '08'
doi: 10.1149/1.2913095
extern: '1'
intvolume: ' 155'
issue: '7'
language:
- iso: eng
month: '05'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
issn:
- 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: Cell interaction phenomena in polymer electrolyte fuel cell stacks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 155
year: '2008'
...
---
_id: '7322'
abstract:
- lang: eng
text: The gas diffusion layers (GDLs) of a membrane electrode assembly (MEA) serve
as link between flow field and porous electrode within a polymer electrolyte fuel
cell. Beside ensuring sufficient electrical and thermal contact between the whole
electrode area and the flow field, these typically 200–400 μm thick porous structures
enable the access of educts to the electrode area which would be occluded by the
flow field lands if the flow field is directly attached to the electrode. Hence,
the characterisation of properties pertaining to mass transport of educts and
products through these structures is indispensable whilst examining the contribution
of the GDLs to the overall electrochemical characteristics of a MEA. A fast and
cost effective method to measure the effective diffusivity of a GDL is presented.
Electrochemical impedance spectroscopy is applied to measure the effective ionic
conductivity of an electrolyte-soaked GDL. Taking advantage of the analogy between
Ficks and Ohms law, this provides a measure for the effective diffusivity. The
method is described in detail, including experimental as well as theoretical aspects,
and selected results, highlighting the anisotropy and dependence on the degree
of compression, are shown. Moreover, a two-dimensional model consisting of regularly
spaced ellipses is developed to represent the porous structure of the GDL, and
by using conformal maps, the agreement between this model and experiment with
respect to the sensitivity of the effective diffusivity towards compression is
shown.
article_processing_charge: No
article_type: original
author:
- first_name: Denis
full_name: Kramer, Denis
last_name: Kramer
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Reto
full_name: Flückiger, Reto
last_name: Flückiger
- first_name: Ingo A.
full_name: Schneider, Ingo A.
last_name: Schneider
- first_name: Alexander
full_name: Wokaun, Alexander
last_name: Wokaun
- first_name: Felix N.
full_name: Büchi, Felix N.
last_name: Büchi
- first_name: Günther G.
full_name: Scherer, Günther G.
last_name: Scherer
citation:
ama: Kramer D, Freunberger SA, Flückiger R, et al. Electrochemical diffusimetry
of fuel cell gas diffusion layers. Journal of Electroanalytical Chemistry.
2008;612(1):63-77. doi:10.1016/j.jelechem.2007.09.014
apa: Kramer, D., Freunberger, S. A., Flückiger, R., Schneider, I. A., Wokaun, A.,
Büchi, F. N., & Scherer, G. G. (2008). Electrochemical diffusimetry of fuel
cell gas diffusion layers. Journal of Electroanalytical Chemistry. Elsevier.
https://doi.org/10.1016/j.jelechem.2007.09.014
chicago: Kramer, Denis, Stefan Alexander Freunberger, Reto Flückiger, Ingo A. Schneider,
Alexander Wokaun, Felix N. Büchi, and Günther G. Scherer. “Electrochemical Diffusimetry
of Fuel Cell Gas Diffusion Layers.” Journal of Electroanalytical Chemistry.
Elsevier, 2008. https://doi.org/10.1016/j.jelechem.2007.09.014.
ieee: D. Kramer et al., “Electrochemical diffusimetry of fuel cell gas diffusion
layers,” Journal of Electroanalytical Chemistry, vol. 612, no. 1. Elsevier,
pp. 63–77, 2008.
ista: Kramer D, Freunberger SA, Flückiger R, Schneider IA, Wokaun A, Büchi FN, Scherer
GG. 2008. Electrochemical diffusimetry of fuel cell gas diffusion layers. Journal
of Electroanalytical Chemistry. 612(1), 63–77.
mla: Kramer, Denis, et al. “Electrochemical Diffusimetry of Fuel Cell Gas Diffusion
Layers.” Journal of Electroanalytical Chemistry, vol. 612, no. 1, Elsevier,
2008, pp. 63–77, doi:10.1016/j.jelechem.2007.09.014.
short: D. Kramer, S.A. Freunberger, R. Flückiger, I.A. Schneider, A. Wokaun, F.N.
Büchi, G.G. Scherer, Journal of Electroanalytical Chemistry 612 (2008) 63–77.
date_created: 2020-01-15T12:21:57Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T08:13:03Z
day: '01'
doi: 10.1016/j.jelechem.2007.09.014
extern: '1'
intvolume: ' 612'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 63-77
publication: Journal of Electroanalytical Chemistry
publication_identifier:
issn:
- 1572-6657
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Electrochemical diffusimetry of fuel cell gas diffusion layers
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 612
year: '2008'
...
---
_id: '7425'
abstract:
- lang: eng
text: The propagation of single cell performance losses to adjacent cells in a polymer
electrolyte fuel cell stack is studied by means of local current density measurements
in a two cell stack. In this stack, the working conditions of adjacent cells can
be controlled independently in order to deliberately change the performance of
one cell (inducing cell) and study the coupling effects to the adjacent cell (response
cell), while keeping the working conditions of the later one unchanged. The experiments
have shown that changes in the current density distribution caused by lowering
of the air stoichiometry in the inducing cell cause changes in the current density
distribution of the response cell in the order of 60% of the change of the inducing
cell, even when the air stoichiometry of the response cell is kept constant. The
losses in cell voltage of the inducing cell cause losses in cell voltage of the
response cell in a magnitude between 30 and 50%.
article_processing_charge: No
author:
- first_name: Marco
full_name: Santis, Marco
last_name: Santis
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Matthias
full_name: Papra, Matthias
last_name: Papra
- first_name: Felix N.
full_name: Büchi, Felix N.
last_name: Büchi
citation:
ama: 'Santis M, Freunberger SA, Papra M, Büchi FN. Experimental investigation of
the propagation of local current density variations to adjacent cells in PEFC
stacks. In: 3rd International Conference on Fuel Cell Science, Engineering
and Technology. ASMEDC; 2008:763-765. doi:10.1115/fuelcell2005-74116'
apa: 'Santis, M., Freunberger, S. A., Papra, M., & Büchi, F. N. (2008). Experimental
investigation of the propagation of local current density variations to adjacent
cells in PEFC stacks. In 3rd International Conference on Fuel Cell Science,
Engineering and Technology (pp. 763–765). Ypsilanti, MI, United States: ASMEDC.
https://doi.org/10.1115/fuelcell2005-74116'
chicago: Santis, Marco, Stefan Alexander Freunberger, Matthias Papra, and Felix
N. Büchi. “Experimental Investigation of the Propagation of Local Current Density
Variations to Adjacent Cells in PEFC Stacks.” In 3rd International Conference
on Fuel Cell Science, Engineering and Technology, 763–65. ASMEDC, 2008. https://doi.org/10.1115/fuelcell2005-74116.
ieee: M. Santis, S. A. Freunberger, M. Papra, and F. N. Büchi, “Experimental investigation
of the propagation of local current density variations to adjacent cells in PEFC
stacks,” in 3rd International Conference on Fuel Cell Science, Engineering
and Technology, Ypsilanti, MI, United States, 2008, pp. 763–765.
ista: Santis M, Freunberger SA, Papra M, Büchi FN. 2008. Experimental investigation
of the propagation of local current density variations to adjacent cells in PEFC
stacks. 3rd International Conference on Fuel Cell Science, Engineering and Technology.
International conference on fuel cell science, engineering and technology, 763–765.
mla: Santis, Marco, et al. “Experimental Investigation of the Propagation of Local
Current Density Variations to Adjacent Cells in PEFC Stacks.” 3rd International
Conference on Fuel Cell Science, Engineering and Technology, ASMEDC, 2008,
pp. 763–65, doi:10.1115/fuelcell2005-74116.
short: M. Santis, S.A. Freunberger, M. Papra, F.N. Büchi, in:, 3rd International
Conference on Fuel Cell Science, Engineering and Technology, ASMEDC, 2008, pp.
763–765.
conference:
end_date: 2005-05-25
location: Ypsilanti, MI, United States
name: International conference on fuel cell science, engineering and technology
start_date: 2005-05-23
date_created: 2020-01-31T10:14:45Z
date_published: 2008-10-13T00:00:00Z
date_updated: 2021-01-12T08:13:33Z
day: '13'
doi: 10.1115/fuelcell2005-74116
extern: '1'
language:
- iso: eng
month: '10'
oa_version: None
page: 763-765
publication: 3rd International Conference on Fuel Cell Science, Engineering and Technology
publication_identifier:
isbn:
- '0791837645'
- '0791837572'
publication_status: published
publisher: ASMEDC
quality_controlled: '1'
status: public
title: Experimental investigation of the propagation of local current density variations
to adjacent cells in PEFC stacks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2008'
...
---
_id: '753'
abstract:
- lang: eng
text: 'This paper addresses the following question: what is the minimum-sized synchronous
window needed to solve consensus in an otherwise asynchronous system? In answer
to this question, we present the first optimally-resilient algorithm ASAP that
solves consensus as soon as possible in an eventually synchronous system, i.e.,
a system that from some time GST onwards, delivers messages in a timely fashion.
ASAP guarantees that, in an execution with at most f failures, every process decides
no later than round GST + f + 2, which is optimal.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Seth
full_name: Gilbert, Seth
last_name: Gilbert
- first_name: Rachid
full_name: Guerraoui, Rachid
last_name: Guerraoui
- first_name: Corentin
full_name: Travers, Corentin
last_name: Travers
citation:
ama: 'Alistarh D-A, Gilbert S, Guerraoui R, Travers C. How to solve consensus in
the smallest window of synchrony. In: Vol 5218 LNCS. Springer; 2008:32-46. doi:10.1007/978-3-540-87779-0_3'
apa: 'Alistarh, D.-A., Gilbert, S., Guerraoui, R., & Travers, C. (2008). How
to solve consensus in the smallest window of synchrony (Vol. 5218 LNCS, pp. 32–46).
Presented at the DISC: Distributed Computing, Springer. https://doi.org/10.1007/978-3-540-87779-0_3'
chicago: Alistarh, Dan-Adrian, Seth Gilbert, Rachid Guerraoui, and Corentin Travers.
“How to Solve Consensus in the Smallest Window of Synchrony,” 5218 LNCS:32–46.
Springer, 2008. https://doi.org/10.1007/978-3-540-87779-0_3.
ieee: 'D.-A. Alistarh, S. Gilbert, R. Guerraoui, and C. Travers, “How to solve consensus
in the smallest window of synchrony,” presented at the DISC: Distributed Computing,
2008, vol. 5218 LNCS, pp. 32–46.'
ista: 'Alistarh D-A, Gilbert S, Guerraoui R, Travers C. 2008. How to solve consensus
in the smallest window of synchrony. DISC: Distributed Computing, LNCS, vol. 5218
LNCS, 32–46.'
mla: Alistarh, Dan-Adrian, et al. How to Solve Consensus in the Smallest Window
of Synchrony. Vol. 5218 LNCS, Springer, 2008, pp. 32–46, doi:10.1007/978-3-540-87779-0_3.
short: D.-A. Alistarh, S. Gilbert, R. Guerraoui, C. Travers, in:, Springer, 2008,
pp. 32–46.
conference:
name: 'DISC: Distributed Computing'
date_created: 2018-12-11T11:48:19Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2023-02-23T13:10:13Z
day: '01'
doi: 10.1007/978-3-540-87779-0_3
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 32 - 46
publication_status: published
publisher: Springer
publist_id: '6904'
status: public
title: How to solve consensus in the smallest window of synchrony
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5218 LNCS
year: '2008'
...
---
_id: '7752'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Jill G.
full_name: Pilkington, Jill G.
last_name: Pilkington
- first_name: Tim H.
full_name: Clutton-Brock, Tim H.
last_name: Clutton-Brock
- first_name: Josephine M.
full_name: Pemberton, Josephine M.
last_name: Pemberton
- first_name: Loeske. E.B.
full_name: Kruuk, Loeske. E.B.
last_name: Kruuk
citation:
ama: Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. Environmental
heterogeneity generates fluctuating selection on a secondary sexual trait. Current
Biology. 2008;18(10):751-757. doi:10.1016/j.cub.2008.04.059
apa: Robinson, M. R., Pilkington, J. G., Clutton-Brock, T. H., Pemberton, J. M.,
& Kruuk, L. E. B. (2008). Environmental heterogeneity generates fluctuating
selection on a secondary sexual trait. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2008.04.059
chicago: Robinson, Matthew Richard, Jill G. Pilkington, Tim H. Clutton-Brock, Josephine
M. Pemberton, and Loeske. E.B. Kruuk. “Environmental Heterogeneity Generates Fluctuating
Selection on a Secondary Sexual Trait.” Current Biology. Elsevier, 2008.
https://doi.org/10.1016/j.cub.2008.04.059.
ieee: M. R. Robinson, J. G. Pilkington, T. H. Clutton-Brock, J. M. Pemberton, and
L. E. B. Kruuk, “Environmental heterogeneity generates fluctuating selection on
a secondary sexual trait,” Current Biology, vol. 18, no. 10. Elsevier,
pp. 751–757, 2008.
ista: Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. 2008.
Environmental heterogeneity generates fluctuating selection on a secondary sexual
trait. Current Biology. 18(10), 751–757.
mla: Robinson, Matthew Richard, et al. “Environmental Heterogeneity Generates Fluctuating
Selection on a Secondary Sexual Trait.” Current Biology, vol. 18, no. 10,
Elsevier, 2008, pp. 751–57, doi:10.1016/j.cub.2008.04.059.
short: M.R. Robinson, J.G. Pilkington, T.H. Clutton-Brock, J.M. Pemberton, L.E.B.
Kruuk, Current Biology 18 (2008) 751–757.
date_created: 2020-04-30T11:02:13Z
date_published: 2008-05-20T00:00:00Z
date_updated: 2021-01-12T08:15:17Z
day: '20'
doi: 10.1016/j.cub.2008.04.059
extern: '1'
intvolume: ' 18'
issue: '10'
language:
- iso: eng
month: '05'
oa_version: None
page: 751-757
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Environmental heterogeneity generates fluctuating selection on a secondary
sexual trait
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2008'
...
---
_id: '581'
abstract:
- lang: eng
text: We have detected a spin-dependent displacement perpendicular to the refractive
index gradient for photons passing through an air-glass interface. The effect
is the photonic version of the spin Hall effect in electronic systems, indicating
the universality of the effect for particles of different nature. Treating the
effect as a weak measurement of the spin projection of the photons, we used a
preselection and postselection technique on the spin state to enhance the original
displacement by nearly four orders of magnitude, attaining sensitivity to displacements
of ∼1 angstrom. The spin Hall effect can be used for manipulating photonic angular
momentum states, and the measurement technique holds promise for precision metrology.
author:
- first_name: Onur
full_name: Onur Hosten
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
- first_name: Paul
full_name: Kwiat, Paul
last_name: Kwiat
citation:
ama: Hosten O, Kwiat P. Observation of the spin hall effect of light via weak measurements.
Science. 2008;319(5864):787-790. doi:10.1126/science.1152697
apa: Hosten, O., & Kwiat, P. (2008). Observation of the spin hall effect of
light via weak measurements. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1152697
chicago: Hosten, Onur, and Paul Kwiat. “Observation of the Spin Hall Effect of Light
via Weak Measurements.” Science. American Association for the Advancement
of Science, 2008. https://doi.org/10.1126/science.1152697.
ieee: O. Hosten and P. Kwiat, “Observation of the spin hall effect of light via
weak measurements,” Science, vol. 319, no. 5864. American Association for
the Advancement of Science, pp. 787–790, 2008.
ista: Hosten O, Kwiat P. 2008. Observation of the spin hall effect of light via
weak measurements. Science. 319(5864), 787–790.
mla: Hosten, Onur, and Paul Kwiat. “Observation of the Spin Hall Effect of Light
via Weak Measurements.” Science, vol. 319, no. 5864, American Association
for the Advancement of Science, 2008, pp. 787–90, doi:10.1126/science.1152697.
short: O. Hosten, P. Kwiat, Science 319 (2008) 787–790.
date_created: 2018-12-11T11:47:19Z
date_published: 2008-02-08T00:00:00Z
date_updated: 2021-01-12T08:03:38Z
day: '08'
doi: 10.1126/science.1152697
extern: 1
intvolume: ' 319'
issue: '5864'
month: '02'
page: 787 - 790
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '7226'
quality_controlled: 0
status: public
title: Observation of the spin hall effect of light via weak measurements
type: journal_article
volume: 319
year: '2008'
...
---
_id: '584'
abstract:
- lang: eng
text: Using “quantum weak-measurements” as a coherent enhancement technique for
small signals, we have measured the recently proposed “spin Hall effect” of light
at an air-glass interface, and are working on the smoothly varying refractive-index
case.
alternative_title:
- Optics InfoBase Conference Papers
article_processing_charge: No
author:
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
- first_name: Paul
full_name: Kwiat, Paul
last_name: Kwiat
citation:
ama: 'Hosten O, Kwiat P. Spin hall effect of light via weak measurements: Sharp
and smooth index variations. In: Optica Publishing Group; 2008.'
apa: 'Hosten, O., & Kwiat, P. (2008). Spin hall effect of light via weak measurements:
Sharp and smooth index variations. Presented at the QELS: Quantum Electronics
and Laser Science Conference, San Jose, CA, United States: Optica Publishing Group.'
chicago: 'Hosten, Onur, and Paul Kwiat. “Spin Hall Effect of Light via Weak Measurements:
Sharp and Smooth Index Variations.” Optica Publishing Group, 2008.'
ieee: 'O. Hosten and P. Kwiat, “Spin hall effect of light via weak measurements:
Sharp and smooth index variations,” presented at the QELS: Quantum Electronics
and Laser Science Conference, San Jose, CA, United States, 2008.'
ista: 'Hosten O, Kwiat P. 2008. Spin hall effect of light via weak measurements:
Sharp and smooth index variations. QELS: Quantum Electronics and Laser Science
Conference, Optics InfoBase Conference Papers, .'
mla: 'Hosten, Onur, and Paul Kwiat. Spin Hall Effect of Light via Weak Measurements:
Sharp and Smooth Index Variations. Optica Publishing Group, 2008.'
short: O. Hosten, P. Kwiat, in:, Optica Publishing Group, 2008.
conference:
end_date: 2008-05-09
location: San Jose, CA, United States
name: 'QELS: Quantum Electronics and Laser Science Conference'
start_date: 2008-05-04
corr_author: '1'
date_created: 2018-12-11T11:47:20Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2024-10-09T20:53:53Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://opg.optica.org/abstract.cfm?URI=QELS-2008-QFB7
month: '01'
oa_version: None
publication_identifier:
isbn:
- 978-155752859-9
issn:
- '21622701'
publication_status: published
publisher: Optica Publishing Group
publist_id: '7227'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spin hall effect of light via weak measurements: Sharp and smooth index variations'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2008'
...