---
_id: '8026'
abstract:
- lang: eng
text: Recent theoretical work has provided a basic understanding of signal propagation
in networks of spiking neurons, but mechanisms for gating and controlling these
signals have not been investigated previously. Here we introduce an idea for the
gating of multiple signals in cortical networks that combines principles of signal
propagation with aspects of balanced networks. Specifically, we studied networks
in which incoming excitatory signals are normally cancelled by locally evoked
inhibition, leaving the targeted layer unresponsive. Transmission can be gated
'on' by modulating excitatory and inhibitory gains to upset this detailed balance.
We illustrate gating through detailed balance in large networks of integrate-and-fire
neurons. We show successful gating of multiple signals and study failure modes
that produce effects reminiscent of clinically observed pathologies. Provided
that the individual signals are detectable, detailed balance has a large capacity
for gating multiple signals.
article_processing_charge: No
article_type: original
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: L F
full_name: Abbott, L F
last_name: Abbott
citation:
ama: Vogels TP, Abbott LF. Gating multiple signals through detailed balance of excitation
and inhibition in spiking networks. Nature Neuroscience. 2009;12(4):483-491.
doi:10.1038/nn.2276
apa: Vogels, T. P., & Abbott, L. F. (2009). Gating multiple signals through
detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience.
Springer Nature. https://doi.org/10.1038/nn.2276
chicago: Vogels, Tim P, and L F Abbott. “Gating Multiple Signals through Detailed
Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience.
Springer Nature, 2009. https://doi.org/10.1038/nn.2276.
ieee: T. P. Vogels and L. F. Abbott, “Gating multiple signals through detailed balance
of excitation and inhibition in spiking networks,” Nature Neuroscience,
vol. 12, no. 4. Springer Nature, pp. 483–491, 2009.
ista: Vogels TP, Abbott LF. 2009. Gating multiple signals through detailed balance
of excitation and inhibition in spiking networks. Nature Neuroscience. 12(4),
483–491.
mla: Vogels, Tim P., and L. F. Abbott. “Gating Multiple Signals through Detailed
Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience,
vol. 12, no. 4, Springer Nature, 2009, pp. 483–91, doi:10.1038/nn.2276.
short: T.P. Vogels, L.F. Abbott, Nature Neuroscience 12 (2009) 483–491.
date_created: 2020-06-25T13:10:55Z
date_published: 2009-04-01T00:00:00Z
date_updated: 2021-01-12T08:16:36Z
day: '01'
doi: 10.1038/nn.2276
extern: '1'
external_id:
pmid:
- '19305402'
intvolume: ' 12'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693069/
month: '04'
oa: 1
oa_version: Submitted Version
page: 483-491
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Gating multiple signals through detailed balance of excitation and inhibition
in spiking networks
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 12
year: '2009'
...
---
_id: '8474'
abstract:
- lang: eng
text: Hydrogen bonds are ubiquitous interactions in proteins, and are important
for their folding and functionality. Scalar coupling constants across hydrogen
bonds in the protein backbone, some as small as 0.5 Hz, can be directly measured
in the solid state by NMR spectroscopy (see figure). The nuclei on both sides
of the hydrogen bond can be identified and the size of the coupling constant can
be measured accurately.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Matthias
full_name: Huber, Matthias
last_name: Huber
- first_name: René
full_name: Verel, René
last_name: Verel
- first_name: Matthias
full_name: Ernst, Matthias
last_name: Ernst
- first_name: "Beatâ\x80\NH."
full_name: "Meier, Beatâ\x80\NH."
last_name: Meier
citation:
ama: Schanda P, Huber M, Verel R, Ernst M, Meier B. Direct detection of 3hJN’ hydrogen-bond
scalar couplings in proteins by solid-state NMR spectroscopy. Angewandte Chemie
International Edition. 2009;48(49):9322-9325. doi:10.1002/anie.200904411
apa: Schanda, P., Huber, M., Verel, R., Ernst, M., & Meier, B. (2009). Direct
detection of 3hJN’ hydrogen-bond scalar couplings in proteins by solid-state NMR
spectroscopy. Angewandte Chemie International Edition. Wiley. https://doi.org/10.1002/anie.200904411
chicago: "Schanda, Paul, Matthias Huber, René Verel, Matthias Ernst, and Beatâ\x80\NH.
Meier. “Direct Detection of 3hJN’ Hydrogen-Bond Scalar Couplings in Proteins by
Solid-State NMR Spectroscopy.” Angewandte Chemie International Edition.
Wiley, 2009. https://doi.org/10.1002/anie.200904411."
ieee: P. Schanda, M. Huber, R. Verel, M. Ernst, and B. Meier, “Direct detection
of 3hJN’ hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy,”
Angewandte Chemie International Edition, vol. 48, no. 49. Wiley, pp. 9322–9325,
2009.
ista: Schanda P, Huber M, Verel R, Ernst M, Meier B. 2009. Direct detection of 3hJN’
hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy. Angewandte
Chemie International Edition. 48(49), 9322–9325.
mla: Schanda, Paul, et al. “Direct Detection of 3hJN’ Hydrogen-Bond Scalar Couplings
in Proteins by Solid-State NMR Spectroscopy.” Angewandte Chemie International
Edition, vol. 48, no. 49, Wiley, 2009, pp. 9322–25, doi:10.1002/anie.200904411.
short: P. Schanda, M. Huber, R. Verel, M. Ernst, B. Meier, Angewandte Chemie International
Edition 48 (2009) 9322–9325.
date_created: 2020-09-18T10:11:33Z
date_published: 2009-11-17T00:00:00Z
date_updated: 2021-01-12T08:19:31Z
day: '17'
doi: 10.1002/anie.200904411
extern: '1'
intvolume: ' 48'
issue: '49'
keyword:
- General Chemistry
- Catalysis
language:
- iso: eng
month: '11'
oa_version: None
page: 9322-9325
publication: Angewandte Chemie International Edition
publication_identifier:
issn:
- 1433-7851
- 1521-3773
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Direct detection of 3hJN' hydrogen-bond scalar couplings in proteins by solid-state
NMR spectroscopy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2009'
...
---
_id: '8475'
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: 'Schanda P. Fast-pulsing longitudinal relaxation optimized techniques: Enriching
the toolbox of fast biomolecular NMR spectroscopy. Progress in Nuclear Magnetic
Resonance Spectroscopy. 2009;55(3):238-265. doi:10.1016/j.pnmrs.2009.05.002'
apa: 'Schanda, P. (2009). Fast-pulsing longitudinal relaxation optimized techniques:
Enriching the toolbox of fast biomolecular NMR spectroscopy. Progress in Nuclear
Magnetic Resonance Spectroscopy. Elsevier. https://doi.org/10.1016/j.pnmrs.2009.05.002'
chicago: 'Schanda, Paul. “Fast-Pulsing Longitudinal Relaxation Optimized Techniques:
Enriching the Toolbox of Fast Biomolecular NMR Spectroscopy.” Progress in Nuclear
Magnetic Resonance Spectroscopy. Elsevier, 2009. https://doi.org/10.1016/j.pnmrs.2009.05.002.'
ieee: 'P. Schanda, “Fast-pulsing longitudinal relaxation optimized techniques: Enriching
the toolbox of fast biomolecular NMR spectroscopy,” Progress in Nuclear Magnetic
Resonance Spectroscopy, vol. 55, no. 3. Elsevier, pp. 238–265, 2009.'
ista: 'Schanda P. 2009. Fast-pulsing longitudinal relaxation optimized techniques:
Enriching the toolbox of fast biomolecular NMR spectroscopy. Progress in Nuclear
Magnetic Resonance Spectroscopy. 55(3), 238–265.'
mla: 'Schanda, Paul. “Fast-Pulsing Longitudinal Relaxation Optimized Techniques:
Enriching the Toolbox of Fast Biomolecular NMR Spectroscopy.” Progress in Nuclear
Magnetic Resonance Spectroscopy, vol. 55, no. 3, Elsevier, 2009, pp. 238–65,
doi:10.1016/j.pnmrs.2009.05.002.'
short: P. Schanda, Progress in Nuclear Magnetic Resonance Spectroscopy 55 (2009)
238–265.
date_created: 2020-09-18T10:11:42Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2021-01-12T08:19:32Z
day: '01'
doi: 10.1016/j.pnmrs.2009.05.002
extern: '1'
intvolume: ' 55'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 238-265
publication: Progress in Nuclear Magnetic Resonance Spectroscopy
publication_identifier:
issn:
- 0079-6565
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Fast-pulsing longitudinal relaxation optimized techniques: Enriching the toolbox
of fast biomolecular NMR spectroscopy'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2009'
...
---
_id: '8476'
abstract:
- lang: eng
text: Atomic-resolution information on the structure and dynamics of nucleic acids
is essential for a better understanding of the mechanistic basis of many cellular
processes. NMR spectroscopy is a powerful method for studying the structure and
dynamics of nucleic acids; however, solution NMR studies are currently limited
to relatively small nucleic acids at high concentrations. Thus, technological
and methodological improvements that increase the experimental sensitivity and
spectral resolution of NMR spectroscopy are required for studies of larger nucleic
acids or protein−nucleic acid complexes. Here we introduce a series of imino-proton-detected
NMR experiments that yield an over 2-fold increase in sensitivity compared to
conventional pulse schemes. These methods can be applied to the detection of base
pair interactions, RNA−ligand titration experiments, measurement of residual dipolar
15N−1H couplings, and direct measurements of conformational transitions. These
NMR experiments employ longitudinal spin relaxation enhancement techniques that
have proven useful in protein NMR spectroscopy. The performance of these new experiments
is demonstrated for a 10 kDa TAR-TAR*GA RNA kissing complex and a 26 kDa tRNA.
article_processing_charge: No
article_type: original
author:
- first_name: Jonathan
full_name: Farjon, Jonathan
last_name: Farjon
- first_name: Jérôme
full_name: Boisbouvier, Jérôme
last_name: Boisbouvier
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Arthur
full_name: Pardi, Arthur
last_name: Pardi
- first_name: Jean-Pierre
full_name: Simorre, Jean-Pierre
last_name: Simorre
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Farjon J, Boisbouvier J, Schanda P, Pardi A, Simorre J-P, Brutscher B. Longitudinal-relaxation-enhanced
NMR experiments for the study of nucleic acids in solution. Journal of the
American Chemical Society. 2009;131(24):8571-8577. doi:10.1021/ja901633y
apa: Farjon, J., Boisbouvier, J., Schanda, P., Pardi, A., Simorre, J.-P., &
Brutscher, B. (2009). Longitudinal-relaxation-enhanced NMR experiments for the
study of nucleic acids in solution. Journal of the American Chemical Society.
American Chemical Society. https://doi.org/10.1021/ja901633y
chicago: Farjon, Jonathan, Jérôme Boisbouvier, Paul Schanda, Arthur Pardi, Jean-Pierre
Simorre, and Bernhard Brutscher. “Longitudinal-Relaxation-Enhanced NMR Experiments
for the Study of Nucleic Acids in Solution.” Journal of the American Chemical
Society. American Chemical Society, 2009. https://doi.org/10.1021/ja901633y.
ieee: J. Farjon, J. Boisbouvier, P. Schanda, A. Pardi, J.-P. Simorre, and B. Brutscher,
“Longitudinal-relaxation-enhanced NMR experiments for the study of nucleic acids
in solution,” Journal of the American Chemical Society, vol. 131, no. 24.
American Chemical Society, pp. 8571–8577, 2009.
ista: Farjon J, Boisbouvier J, Schanda P, Pardi A, Simorre J-P, Brutscher B. 2009.
Longitudinal-relaxation-enhanced NMR experiments for the study of nucleic acids
in solution. Journal of the American Chemical Society. 131(24), 8571–8577.
mla: Farjon, Jonathan, et al. “Longitudinal-Relaxation-Enhanced NMR Experiments
for the Study of Nucleic Acids in Solution.” Journal of the American Chemical
Society, vol. 131, no. 24, American Chemical Society, 2009, pp. 8571–77, doi:10.1021/ja901633y.
short: J. Farjon, J. Boisbouvier, P. Schanda, A. Pardi, J.-P. Simorre, B. Brutscher,
Journal of the American Chemical Society 131 (2009) 8571–8577.
date_created: 2020-09-18T10:11:49Z
date_published: 2009-06-01T00:00:00Z
date_updated: 2021-01-12T08:19:32Z
day: '01'
doi: 10.1021/ja901633y
extern: '1'
intvolume: ' 131'
issue: '24'
language:
- iso: eng
month: '06'
oa_version: None
page: 8571-8577
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Longitudinal-relaxation-enhanced NMR experiments for the study of nucleic acids
in solution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 131
year: '2009'
...
---
_id: '8477'
abstract:
- lang: eng
text: An optimized NMR experiment that combines the advantages of methyl-TROSY and
SOFAST-HMQC has been developed. It allows the recording of high quality methyl
1H−13C correlation spectra of protein assemblies of several hundreds of kDa in
a few seconds. The SOFAST-methyl-TROSY-based experiment offers completely new
opportunities for the study of structural and dynamic changes occurring in molecular
nanomachines while they perform their biological function in vitro.
article_processing_charge: No
article_type: original
author:
- first_name: Carlos
full_name: Amero, Carlos
last_name: Amero
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: M. Asunción
full_name: Durá, M. Asunción
last_name: Durá
- first_name: Isabel
full_name: Ayala, Isabel
last_name: Ayala
- first_name: Dominique
full_name: Marion, Dominique
last_name: Marion
- first_name: Bruno
full_name: Franzetti, Bruno
last_name: Franzetti
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
- first_name: Jérôme
full_name: Boisbouvier, Jérôme
last_name: Boisbouvier
citation:
ama: Amero C, Schanda P, Durá MA, et al. Fast two-dimensional NMR spectroscopy
of high molecular weight protein assemblies. Journal of the American Chemical
Society. 2009;131(10):3448-3449. doi:10.1021/ja809880p
apa: Amero, C., Schanda, P., Durá, M. A., Ayala, I., Marion, D., Franzetti, B.,
… Boisbouvier, J. (2009). Fast two-dimensional NMR spectroscopy of high molecular
weight protein assemblies. Journal of the American Chemical Society. American
Chemical Society. https://doi.org/10.1021/ja809880p
chicago: Amero, Carlos, Paul Schanda, M. Asunción Durá, Isabel Ayala, Dominique
Marion, Bruno Franzetti, Bernhard Brutscher, and Jérôme Boisbouvier. “Fast Two-Dimensional
NMR Spectroscopy of High Molecular Weight Protein Assemblies.” Journal of the
American Chemical Society. American Chemical Society, 2009. https://doi.org/10.1021/ja809880p.
ieee: C. Amero et al., “Fast two-dimensional NMR spectroscopy of high molecular
weight protein assemblies,” Journal of the American Chemical Society, vol.
131, no. 10. American Chemical Society, pp. 3448–3449, 2009.
ista: Amero C, Schanda P, Durá MA, Ayala I, Marion D, Franzetti B, Brutscher B,
Boisbouvier J. 2009. Fast two-dimensional NMR spectroscopy of high molecular weight
protein assemblies. Journal of the American Chemical Society. 131(10), 3448–3449.
mla: Amero, Carlos, et al. “Fast Two-Dimensional NMR Spectroscopy of High Molecular
Weight Protein Assemblies.” Journal of the American Chemical Society, vol.
131, no. 10, American Chemical Society, 2009, pp. 3448–49, doi:10.1021/ja809880p.
short: C. Amero, P. Schanda, M.A. Durá, I. Ayala, D. Marion, B. Franzetti, B. Brutscher,
J. Boisbouvier, Journal of the American Chemical Society 131 (2009) 3448–3449.
date_created: 2020-09-18T10:12:01Z
date_published: 2009-02-25T00:00:00Z
date_updated: 2021-01-12T08:19:32Z
day: '25'
doi: 10.1021/ja809880p
extern: '1'
intvolume: ' 131'
issue: '10'
language:
- iso: eng
month: '02'
oa_version: None
page: 3448-3449
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Fast two-dimensional NMR spectroscopy of high molecular weight protein assemblies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 131
year: '2009'
...
---
_id: '8478'
abstract:
- lang: eng
text: Allosteric regulation is an effective mechanism of control in biological processes.
In allosteric proteins a signal originating at one site in the molecule is communicated
through the protein structure to trigger a specific response at a remote site.
Using NMR relaxation dispersion techniques we directly observe the dynamic process
through which the KIX domain of CREB binding protein communicates allosteric information
between binding sites. KIX mediates cooperativity between pairs of transcription
factors through binding to two distinct interaction surfaces in an allosteric
manner. We show that binding the activation domain of the mixed lineage leukemia
(MLL) transcription factor to KIX induces a redistribution of the relative populations
of KIX conformations toward a high-energy state in which the allosterically activated
second binding site is already preformed, consistent with the Monod−Wyman−Changeux
(WMC) model of allostery. The structural rearrangement process that links the
two conformers and by which allosteric information is communicated occurs with
a time constant of 3 ms at 27 °C. Our dynamic NMR data reveal that an evolutionarily
conserved network of hydrophobic amino acids constitutes the pathway through which
information is transmitted.
article_processing_charge: No
article_type: original
author:
- first_name: Sven
full_name: Brüschweiler, Sven
last_name: Brüschweiler
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Karin
full_name: Kloiber, Karin
last_name: Kloiber
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
- first_name: Georg
full_name: Kontaxis, Georg
last_name: Kontaxis
- first_name: Robert
full_name: Konrat, Robert
last_name: Konrat
- first_name: Martin
full_name: Tollinger, Martin
last_name: Tollinger
citation:
ama: Brüschweiler S, Schanda P, Kloiber K, et al. Direct observation of the dynamic
process underlying allosteric signal transmission. Journal of the American
Chemical Society. 2009;131(8):3063-3068. doi:10.1021/ja809947w
apa: Brüschweiler, S., Schanda, P., Kloiber, K., Brutscher, B., Kontaxis, G., Konrat,
R., & Tollinger, M. (2009). Direct observation of the dynamic process underlying
allosteric signal transmission. Journal of the American Chemical Society.
American Chemical Society. https://doi.org/10.1021/ja809947w
chicago: Brüschweiler, Sven, Paul Schanda, Karin Kloiber, Bernhard Brutscher, Georg
Kontaxis, Robert Konrat, and Martin Tollinger. “Direct Observation of the Dynamic
Process Underlying Allosteric Signal Transmission.” Journal of the American
Chemical Society. American Chemical Society, 2009. https://doi.org/10.1021/ja809947w.
ieee: S. Brüschweiler et al., “Direct observation of the dynamic process
underlying allosteric signal transmission,” Journal of the American Chemical
Society, vol. 131, no. 8. American Chemical Society, pp. 3063–3068, 2009.
ista: Brüschweiler S, Schanda P, Kloiber K, Brutscher B, Kontaxis G, Konrat R,
Tollinger M. 2009. Direct observation of the dynamic process underlying allosteric
signal transmission. Journal of the American Chemical Society. 131(8), 3063–3068.
mla: Brüschweiler, Sven, et al. “Direct Observation of the Dynamic Process Underlying
Allosteric Signal Transmission.” Journal of the American Chemical Society,
vol. 131, no. 8, American Chemical Society, 2009, pp. 3063–68, doi:10.1021/ja809947w.
short: S. Brüschweiler, P. Schanda, K. Kloiber, B. Brutscher, G. Kontaxis, R. Konrat,
M. Tollinger, Journal of the American Chemical Society 131 (2009) 3063–3068.
date_created: 2020-09-18T10:12:14Z
date_published: 2009-02-09T00:00:00Z
date_updated: 2021-01-12T08:19:33Z
day: '09'
doi: 10.1021/ja809947w
extern: '1'
intvolume: ' 131'
issue: '8'
language:
- iso: eng
month: '02'
oa_version: None
page: 3063-3068
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Direct observation of the dynamic process underlying allosteric signal transmission
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 131
year: '2009'
...
---
_id: '8479'
abstract:
- lang: eng
text: Multidimensional NMR spectroscopy is a well-established technique for the
characterization of structure and fast-time-scale dynamics of highly populated
ground states of biological macromolecules. The investigation of short-lived excited
states that are important for molecular folding, misfolding and function, however,
remains a challenge for modern biomolecular NMR techniques. Off-equilibrium real-time
kinetic NMR methods allow direct observation of conformational or chemical changes
by following peak positions and intensities in a series of spectra recorded during
a kinetic event. Because standard multidimensional NMR methods required to yield
sufficient atom-resolution are intrinsically time-consuming, many interesting
phenomena are excluded from real-time NMR analysis. Recently, spatially encoded
ultrafast 2D NMR techniques have been proposed that allow one to acquire a 2D
NMR experiment within a single transient. In addition, when combined with the
SOFAST technique, such ultrafast experiments can be repeated at high rates. One
of the problems detected for such ultrafast protein NMR experiments is related
to the heteronuclear decoupling during detection with interferences between the
pulses and the oscillatory magnetic field gradients arising in this scheme. Here
we present a method for improved ultrafast data acquisition yielding higher signal
to noise and sharper lines in single-scan 2D NMR spectra. In combination with
a fast-mixing device, the recording of 1H–15N correlation spectra with repetition
rates of up to a few Hertz becomes feasible, enabling real-time studies of protein
kinetics occurring on time scales down to a few seconds.
article_processing_charge: No
article_type: original
author:
- first_name: Maayan
full_name: Gal, Maayan
last_name: Gal
- first_name: Thomas
full_name: Kern, Thomas
last_name: Kern
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Lucio
full_name: Frydman, Lucio
last_name: Frydman
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: 'Gal M, Kern T, Schanda P, Frydman L, Brutscher B. An improved ultrafast 2D
NMR experiment: Towards atom-resolved real-time studies of protein kinetics at
multi-Hz rates. Journal of Biomolecular NMR. 2009;43:1-10. doi:10.1007/s10858-008-9284-9'
apa: 'Gal, M., Kern, T., Schanda, P., Frydman, L., & Brutscher, B. (2009). An
improved ultrafast 2D NMR experiment: Towards atom-resolved real-time studies
of protein kinetics at multi-Hz rates. Journal of Biomolecular NMR. Springer
Nature. https://doi.org/10.1007/s10858-008-9284-9'
chicago: 'Gal, Maayan, Thomas Kern, Paul Schanda, Lucio Frydman, and Bernhard Brutscher.
“An Improved Ultrafast 2D NMR Experiment: Towards Atom-Resolved Real-Time Studies
of Protein Kinetics at Multi-Hz Rates.” Journal of Biomolecular NMR. Springer
Nature, 2009. https://doi.org/10.1007/s10858-008-9284-9.'
ieee: 'M. Gal, T. Kern, P. Schanda, L. Frydman, and B. Brutscher, “An improved ultrafast
2D NMR experiment: Towards atom-resolved real-time studies of protein kinetics
at multi-Hz rates,” Journal of Biomolecular NMR, vol. 43. Springer Nature,
pp. 1–10, 2009.'
ista: 'Gal M, Kern T, Schanda P, Frydman L, Brutscher B. 2009. An improved ultrafast
2D NMR experiment: Towards atom-resolved real-time studies of protein kinetics
at multi-Hz rates. Journal of Biomolecular NMR. 43, 1–10.'
mla: 'Gal, Maayan, et al. “An Improved Ultrafast 2D NMR Experiment: Towards Atom-Resolved
Real-Time Studies of Protein Kinetics at Multi-Hz Rates.” Journal of Biomolecular
NMR, vol. 43, Springer Nature, 2009, pp. 1–10, doi:10.1007/s10858-008-9284-9.'
short: M. Gal, T. Kern, P. Schanda, L. Frydman, B. Brutscher, Journal of Biomolecular
NMR 43 (2009) 1–10.
date_created: 2020-09-18T10:12:20Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T08:19:33Z
day: '01'
doi: 10.1007/s10858-008-9284-9
extern: '1'
intvolume: ' 43'
keyword:
- Spectroscopy
- Biochemistry
language:
- iso: eng
month: '01'
oa_version: None
page: 1-10
publication: Journal of Biomolecular NMR
publication_identifier:
issn:
- 0925-2738
- 1573-5001
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'An improved ultrafast 2D NMR experiment: Towards atom-resolved real-time studies
of protein kinetics at multi-Hz rates'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2009'
...
---
_id: '8508'
abstract:
- lang: eng
text: We study generic unfoldings of homoclinic tangencies of two-dimensional area-preserving
diffeomorphisms (conservative New house phenomena) and show that they give rise
to invariant hyperbolic sets of arbitrarily large Hausdorff dimension. As applications,
we discuss the size of the stochastic layer of a standard map and the Hausdorff
dimension of invariant hyperbolic sets for certain restricted three-body problems.
We avoid involved technical details and only concentrate on the ideas of the proof
of the presented results.
article_processing_charge: No
article_type: original
author:
- first_name: Anton
full_name: Gorodetski, Anton
last_name: Gorodetski
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Gorodetski A, Kaloshin V. Conservative homoclinic bifurcations and some applications.
Proceedings of the Steklov Institute of Mathematics. 2009;267(1):76-90.
doi:10.1134/s0081543809040063
apa: Gorodetski, A., & Kaloshin, V. (2009). Conservative homoclinic bifurcations
and some applications. Proceedings of the Steklov Institute of Mathematics.
Springer Nature. https://doi.org/10.1134/s0081543809040063
chicago: Gorodetski, Anton, and Vadim Kaloshin. “Conservative Homoclinic Bifurcations
and Some Applications.” Proceedings of the Steklov Institute of Mathematics.
Springer Nature, 2009. https://doi.org/10.1134/s0081543809040063.
ieee: A. Gorodetski and V. Kaloshin, “Conservative homoclinic bifurcations and some
applications,” Proceedings of the Steklov Institute of Mathematics, vol.
267, no. 1. Springer Nature, pp. 76–90, 2009.
ista: Gorodetski A, Kaloshin V. 2009. Conservative homoclinic bifurcations and some
applications. Proceedings of the Steklov Institute of Mathematics. 267(1), 76–90.
mla: Gorodetski, Anton, and Vadim Kaloshin. “Conservative Homoclinic Bifurcations
and Some Applications.” Proceedings of the Steklov Institute of Mathematics,
vol. 267, no. 1, Springer Nature, 2009, pp. 76–90, doi:10.1134/s0081543809040063.
short: A. Gorodetski, V. Kaloshin, Proceedings of the Steklov Institute of Mathematics
267 (2009) 76–90.
date_created: 2020-09-18T10:48:03Z
date_published: 2009-12-01T00:00:00Z
date_updated: 2021-01-12T08:19:46Z
day: '01'
doi: 10.1134/s0081543809040063
extern: '1'
intvolume: ' 267'
issue: '1'
keyword:
- Mathematics (miscellaneous)
language:
- iso: eng
month: '12'
oa_version: None
page: 76-90
publication: Proceedings of the Steklov Institute of Mathematics
publication_identifier:
issn:
- 0081-5438
- 1531-8605
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Conservative homoclinic bifurcations and some applications
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 267
year: '2009'
...
---
_id: '88'
abstract:
- lang: eng
text: 'We have developed a tunable source of Mie scale microdroplet aerosols that
can be used for the generation of energetic ions. To demonstrate this potential,
a terawatt Ti: Al2 O3 laser focused to 2×10 19 W/cm2 was used to irradiate heavy
water (D2 O) aerosols composed of micron-scale droplets. Energetic deuterium ions,
which were generated in the laser-droplet interaction, produced deuterium-deuterium
fusion with approximately 2×10^3 fusion neutrons measured per joule of incident
laser energy. '
acknowledgement: This work was supported by the National Science Foundation under
Grant Nos. PHY-0456898, PHY-0757989, and PHY-0456870 and the National Nuclear Security
Administration under Cooperative Agreement No. DE-FC52-03NA00156. Acknowledgment
is made to the Donors of the Petroleum Research Fund administered by the American
Chemical Society for partial support of this research.
article_number: '063503'
author:
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
- first_name: Octavi
full_name: Semonin, Octavi
last_name: Semonin
- first_name: S
full_name: Bruce, S
last_name: Bruce
- first_name: C
full_name: Chan, C
last_name: Chan
- first_name: M
full_name: Maindi, M
last_name: Maindi
- first_name: Tom
full_name: Donnelly, Tom
last_name: Donnelly
- first_name: M
full_name: Maurer, M
last_name: Maurer
- first_name: Woosuk
full_name: Bang, Woosuk
last_name: Bang
- first_name: I.V
full_name: Churina, I.V
last_name: Churina
- first_name: Jens
full_name: Osterholz, Jens
last_name: Osterholz
- first_name: I
full_name: Kim, I
last_name: Kim
- first_name: Aaron
full_name: Bernstein, Aaron
last_name: Bernstein
- first_name: Todd
full_name: Ditmire, Todd
last_name: Ditmire
citation:
ama: Higginbotham AP, Semonin O, Bruce S, et al. Generation of Mie size microdroplet
aerosols with applications in laser-driven fusion experiments. Review of Scientific
Instruments. 2009;80(6). doi:10.1063/1.3155302
apa: Higginbotham, A. P., Semonin, O., Bruce, S., Chan, C., Maindi, M., Donnelly,
T., … Ditmire, T. (2009). Generation of Mie size microdroplet aerosols with applications
in laser-driven fusion experiments. Review of Scientific Instruments. American
Institute of Physics. https://doi.org/10.1063/1.3155302
chicago: Higginbotham, Andrew P, Octavi Semonin, S Bruce, C Chan, M Maindi, Tom
Donnelly, M Maurer, et al. “Generation of Mie Size Microdroplet Aerosols with
Applications in Laser-Driven Fusion Experiments.” Review of Scientific Instruments.
American Institute of Physics, 2009. https://doi.org/10.1063/1.3155302.
ieee: A. P. Higginbotham et al., “Generation of Mie size microdroplet aerosols
with applications in laser-driven fusion experiments,” Review of Scientific
Instruments, vol. 80, no. 6. American Institute of Physics, 2009.
ista: Higginbotham AP, Semonin O, Bruce S, Chan C, Maindi M, Donnelly T, Maurer
M, Bang W, Churina I., Osterholz J, Kim I, Bernstein A, Ditmire T. 2009. Generation
of Mie size microdroplet aerosols with applications in laser-driven fusion experiments.
Review of Scientific Instruments. 80(6), 063503.
mla: Higginbotham, Andrew P., et al. “Generation of Mie Size Microdroplet Aerosols
with Applications in Laser-Driven Fusion Experiments.” Review of Scientific
Instruments, vol. 80, no. 6, 063503, American Institute of Physics, 2009,
doi:10.1063/1.3155302.
short: A.P. Higginbotham, O. Semonin, S. Bruce, C. Chan, M. Maindi, T. Donnelly,
M. Maurer, W. Bang, I.. Churina, J. Osterholz, I. Kim, A. Bernstein, T. Ditmire,
Review of Scientific Instruments 80 (2009).
date_created: 2018-12-11T11:44:34Z
date_published: 2009-06-25T00:00:00Z
date_updated: 2021-01-12T08:21:06Z
day: '25'
doi: 10.1063/1.3155302
extern: '1'
external_id:
pmid:
- ' 19566203'
intvolume: ' 80'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.osti.gov/biblio/22053583
month: '06'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Review of Scientific Instruments
publication_status: published
publisher: American Institute of Physics
publist_id: '7966'
quality_controlled: '1'
status: public
title: Generation of Mie size microdroplet aerosols with applications in laser-driven
fusion experiments
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2009'
...
---
_id: '908'
abstract:
- lang: eng
text: Although some data link archaeal and eukaryotic translation, the overall mechanism
of protein synthesis in archaea remains largely obscure. Both archaeal (aRF1)
and eukaryotic (eRF1) single release factors recognize all three stop codons.
The archaeal genus Methanosarcinaceae contains two aRF1 homologs, and also uses
the UAG stop to encode the 22nd amino acid, pyrrolysine. Here we provide an analysis
of the last stage of archaeal translation in pyrrolysine-utilizing species. We
demonstrated that only one of two Methanosarcina barkeri aRF1 homologs possesses
activity and recognizes all three stop codons. The second aRF1 homolog may have
another unknown function. The mechanism of pyrrolysine incorporation in the Methanosarcinaceae
is discussed.
acknowledgement: We are grateful to Andrey Poltaraus and his colleagues for sequencing
a/eRF1 genes. We thank Tatyana Pestova and Chris Hellen for the gift of plasmids
encoding initiation factors eIF1, eIF1A, eIF4A, eIF4B, eIF4G, eIF5, eIF5B, and Anna
Yaremchuk and Michael Tukalo for M. jannaschii aRF1. This work was supported by
grants from the Presidium of the (Program Molecular and Cell Biology), the Russian
Foundation for Basic Research (08-04-01091-а to E.A. and 08-04-00375a to L.F.),
the National Institute for General Medical Sciences (to D.S.), the National Science
Foundation (to D.S.) and the Office of Basic Energy Sciences, DOE (to D.S.).
author:
- first_name: Elena
full_name: Alkalaeva, Elena Z
last_name: Alkalaeva
- first_name: Boris
full_name: Eliseev, Boris D
last_name: Eliseev
- first_name: Alexandre
full_name: Ambrogelly, Alexandre
last_name: Ambrogelly
- first_name: Peter
full_name: Vlasov, Peter K
last_name: Vlasov
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Sarath
full_name: Gundllapalli, Sarath B
last_name: Gundllapalli
- first_name: Ludmila
full_name: Frolova, Ludmila Y
last_name: Frolova
- first_name: Dieter
full_name: Söll, Dieter G
last_name: Söll
- first_name: Lev
full_name: Kisselev, Lev L
last_name: Kisselev
citation:
ama: Alkalaeva E, Eliseev B, Ambrogelly A, et al. Translation termination in pyrrolysine-utilizing
archaea. FEBS Letters. 2009;583(21):3455-3460. doi:10.1016/j.febslet.2009.09.044
apa: Alkalaeva, E., Eliseev, B., Ambrogelly, A., Vlasov, P., Kondrashov, F., Gundllapalli,
S., … Kisselev, L. (2009). Translation termination in pyrrolysine-utilizing archaea.
FEBS Letters. Elsevier. https://doi.org/10.1016/j.febslet.2009.09.044
chicago: Alkalaeva, Elena, Boris Eliseev, Alexandre Ambrogelly, Peter Vlasov, Fyodor
Kondrashov, Sarath Gundllapalli, Ludmila Frolova, Dieter Söll, and Lev Kisselev.
“Translation Termination in Pyrrolysine-Utilizing Archaea.” FEBS Letters.
Elsevier, 2009. https://doi.org/10.1016/j.febslet.2009.09.044.
ieee: E. Alkalaeva et al., “Translation termination in pyrrolysine-utilizing
archaea,” FEBS Letters, vol. 583, no. 21. Elsevier, pp. 3455–3460, 2009.
ista: Alkalaeva E, Eliseev B, Ambrogelly A, Vlasov P, Kondrashov F, Gundllapalli
S, Frolova L, Söll D, Kisselev L. 2009. Translation termination in pyrrolysine-utilizing
archaea. FEBS Letters. 583(21), 3455–3460.
mla: Alkalaeva, Elena, et al. “Translation Termination in Pyrrolysine-Utilizing
Archaea.” FEBS Letters, vol. 583, no. 21, Elsevier, 2009, pp. 3455–60,
doi:10.1016/j.febslet.2009.09.044.
short: E. Alkalaeva, B. Eliseev, A. Ambrogelly, P. Vlasov, F. Kondrashov, S. Gundllapalli,
L. Frolova, D. Söll, L. Kisselev, FEBS Letters 583 (2009) 3455–3460.
date_created: 2018-12-11T11:49:08Z
date_published: 2009-11-03T00:00:00Z
date_updated: 2021-01-12T08:21:49Z
day: '03'
doi: 10.1016/j.febslet.2009.09.044
extern: 1
intvolume: ' 583'
issue: '21'
month: '11'
page: 3455 - 3460
publication: FEBS Letters
publication_status: published
publisher: Elsevier
publist_id: '6740'
quality_controlled: 0
status: public
title: Translation termination in pyrrolysine-utilizing archaea
type: journal_article
volume: 583
year: '2009'
...
---
_id: '9147'
abstract:
- lang: eng
text: As part of an ongoing effort to develop a parameterization of wave-induced
abyssal mixing, the authors derive an heuristic model for nonlinear wave breaking
and energy dissipation associated with internal tides. Then the saturation and
dissipation of internal tides for idealized and observed topography samples are
investigated. One of the main results is that the wave-induced mixing could be
more intense and more confined to the bottom than previously assumed in numerical
models. Furthermore, in this model wave breaking and mixing clearly depend on
the small scales of the topography below 10 km or so, which is below the current
resolution of global bathymetry. This motivates the use of a statistical approach
to represent the unresolved topography when addressing the role of internal tides
in mixing the deep ocean.
article_processing_charge: No
article_type: original
author:
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Oliver
full_name: Bühler, Oliver
last_name: Bühler
citation:
ama: Muller CJ, Bühler O. Saturation of the internal tides and induced mixing in
the abyssal ocean. Journal of Physical Oceanography. 2009;39(9):2077-2096.
doi:10.1175/2009jpo4141.1
apa: Muller, C. J., & Bühler, O. (2009). Saturation of the internal tides and
induced mixing in the abyssal ocean. Journal of Physical Oceanography.
American Meteorological Society. https://doi.org/10.1175/2009jpo4141.1
chicago: Muller, Caroline J, and Oliver Bühler. “Saturation of the Internal Tides
and Induced Mixing in the Abyssal Ocean.” Journal of Physical Oceanography.
American Meteorological Society, 2009. https://doi.org/10.1175/2009jpo4141.1.
ieee: C. J. Muller and O. Bühler, “Saturation of the internal tides and induced
mixing in the abyssal ocean,” Journal of Physical Oceanography, vol. 39,
no. 9. American Meteorological Society, pp. 2077–2096, 2009.
ista: Muller CJ, Bühler O. 2009. Saturation of the internal tides and induced mixing
in the abyssal ocean. Journal of Physical Oceanography. 39(9), 2077–2096.
mla: Muller, Caroline J., and Oliver Bühler. “Saturation of the Internal Tides and
Induced Mixing in the Abyssal Ocean.” Journal of Physical Oceanography,
vol. 39, no. 9, American Meteorological Society, 2009, pp. 2077–96, doi:10.1175/2009jpo4141.1.
short: C.J. Muller, O. Bühler, Journal of Physical Oceanography 39 (2009) 2077–2096.
date_created: 2021-02-15T14:41:08Z
date_published: 2009-09-01T00:00:00Z
date_updated: 2022-01-24T13:50:37Z
day: '01'
doi: 10.1175/2009jpo4141.1
extern: '1'
intvolume: ' 39'
issue: '9'
keyword:
- Oceanography
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1175/2009JPO4141.1
month: '09'
oa: 1
oa_version: Published Version
page: 2077-2096
publication: Journal of Physical Oceanography
publication_identifier:
issn:
- 1520-0485
- 0022-3670
publication_status: published
publisher: American Meteorological Society
quality_controlled: '1'
status: public
title: Saturation of the internal tides and induced mixing in the abyssal ocean
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 39
year: '2009'
...
---
_id: '9148'
abstract:
- lang: eng
text: Several observational studies have shown a tight relationship between tropical
precipitation and column‐integrated water vapor. We show that the observed relationship
in the tropics between column‐integrated water vapor, precipitation, and its variance
can be qualitatively reproduced by a simple and physically motivated two‐layer
model. It has previously been argued that features of this relationship could
be explained by analogy with the theory of continuous phase transitions. Instead,
our model explicitly assumes that the onset of precipitation is governed by a
stability threshold involving boundary‐layer water vapor. This allows us to explain
the precipitation‐humidity relationship over a broader range of water vapor values,
and may explain the observed temperature dependence of the relationship.
article_number: L16804
article_processing_charge: No
article_type: original
author:
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Larissa E.
full_name: Back, Larissa E.
last_name: Back
- first_name: Paul A.
full_name: O'Gorman, Paul A.
last_name: O'Gorman
- first_name: Kerry A.
full_name: Emanuel, Kerry A.
last_name: Emanuel
citation:
ama: Muller CJ, Back LE, O’Gorman PA, Emanuel KA. A model for the relationship between
tropical precipitation and column water vapor. Geophysical Research Letters.
2009;36(16). doi:10.1029/2009gl039667
apa: Muller, C. J., Back, L. E., O’Gorman, P. A., & Emanuel, K. A. (2009). A
model for the relationship between tropical precipitation and column water vapor.
Geophysical Research Letters. American Geophysical Union. https://doi.org/10.1029/2009gl039667
chicago: Muller, Caroline J, Larissa E. Back, Paul A. O’Gorman, and Kerry A. Emanuel.
“A Model for the Relationship between Tropical Precipitation and Column Water
Vapor.” Geophysical Research Letters. American Geophysical Union, 2009.
https://doi.org/10.1029/2009gl039667.
ieee: C. J. Muller, L. E. Back, P. A. O’Gorman, and K. A. Emanuel, “A model for
the relationship between tropical precipitation and column water vapor,” Geophysical
Research Letters, vol. 36, no. 16. American Geophysical Union, 2009.
ista: Muller CJ, Back LE, O’Gorman PA, Emanuel KA. 2009. A model for the relationship
between tropical precipitation and column water vapor. Geophysical Research Letters.
36(16), L16804.
mla: Muller, Caroline J., et al. “A Model for the Relationship between Tropical
Precipitation and Column Water Vapor.” Geophysical Research Letters, vol.
36, no. 16, L16804, American Geophysical Union, 2009, doi:10.1029/2009gl039667.
short: C.J. Muller, L.E. Back, P.A. O’Gorman, K.A. Emanuel, Geophysical Research
Letters 36 (2009).
date_created: 2021-02-15T14:41:28Z
date_published: 2009-08-25T00:00:00Z
date_updated: 2022-01-24T13:50:15Z
day: '25'
doi: 10.1029/2009gl039667
extern: '1'
intvolume: ' 36'
issue: '16'
keyword:
- General Earth and Planetary Sciences
- Geophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1029/2009GL039667
month: '08'
oa: 1
oa_version: Published Version
publication: Geophysical Research Letters
publication_identifier:
issn:
- 0094-8276
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
status: public
title: A model for the relationship between tropical precipitation and column water
vapor
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 36
year: '2009'
...
---
_id: '9453'
abstract:
- lang: eng
text: Parent-of-origin-specific (imprinted) gene expression is regulated in Arabidopsis
thaliana endosperm by cytosine demethylation of the maternal genome mediated by
the DNA glycosylase DEMETER, but the extent of the methylation changes is not
known. Here, we show that virtually the entire endosperm genome is demethylated,
coupled with extensive local non-CG hypermethylation of small interfering RNA–targeted
sequences. Mutation of DEMETER partially restores endosperm CG methylation to
levels found in other tissues, indicating that CG demethylation is specific to
maternal sequences. Endosperm demethylation is accompanied by CHH hypermethylation
of embryo transposable elements. Our findings demonstrate extensive reconfiguration
of the endosperm methylation landscape that likely reinforces transposon silencing
in the embryo.
article_processing_charge: No
article_type: original
author:
- first_name: Tzung-Fu
full_name: Hsieh, Tzung-Fu
last_name: Hsieh
- first_name: Christian A.
full_name: Ibarra, Christian A.
last_name: Ibarra
- first_name: Pedro
full_name: Silva, Pedro
last_name: Silva
- first_name: Assaf
full_name: Zemach, Assaf
last_name: Zemach
- first_name: Leor
full_name: Eshed-Williams, Leor
last_name: Eshed-Williams
- first_name: Robert L.
full_name: Fischer, Robert L.
last_name: Fischer
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
citation:
ama: Hsieh T-F, Ibarra CA, Silva P, et al. Genome-wide demethylation of Arabidopsis
endosperm. Science. 2009;324(5933):1451-1454. doi:10.1126/science.1172417
apa: Hsieh, T.-F., Ibarra, C. A., Silva, P., Zemach, A., Eshed-Williams, L., Fischer,
R. L., & Zilberman, D. (2009). Genome-wide demethylation of Arabidopsis endosperm.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1172417
chicago: Hsieh, Tzung-Fu, Christian A. Ibarra, Pedro Silva, Assaf Zemach, Leor Eshed-Williams,
Robert L. Fischer, and Daniel Zilberman. “Genome-Wide Demethylation of Arabidopsis
Endosperm.” Science. American Association for the Advancement of Science,
2009. https://doi.org/10.1126/science.1172417.
ieee: T.-F. Hsieh et al., “Genome-wide demethylation of Arabidopsis endosperm,”
Science, vol. 324, no. 5933. American Association for the Advancement of
Science, pp. 1451–1454, 2009.
ista: Hsieh T-F, Ibarra CA, Silva P, Zemach A, Eshed-Williams L, Fischer RL, Zilberman
D. 2009. Genome-wide demethylation of Arabidopsis endosperm. Science. 324(5933),
1451–1454.
mla: Hsieh, Tzung-Fu, et al. “Genome-Wide Demethylation of Arabidopsis Endosperm.”
Science, vol. 324, no. 5933, American Association for the Advancement of
Science, 2009, pp. 1451–54, doi:10.1126/science.1172417.
short: T.-F. Hsieh, C.A. Ibarra, P. Silva, A. Zemach, L. Eshed-Williams, R.L. Fischer,
D. Zilberman, Science 324 (2009) 1451–1454.
date_created: 2021-06-04T08:55:41Z
date_published: 2009-06-12T00:00:00Z
date_updated: 2021-12-14T08:53:26Z
day: '12'
department:
- _id: DaZi
doi: 10.1126/science.1172417
extern: '1'
external_id:
pmid:
- '19520962'
intvolume: ' 324'
issue: '5933'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044190/
month: '06'
oa: 1
oa_version: Submitted Version
page: 1451-1454
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genome-wide demethylation of Arabidopsis endosperm
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 324
year: '2009'
...
---
_id: '964'
abstract:
- lang: eng
text: A theory of the fluctuation-induced Nernst efl'ect is developed for a two-dimensional
superconductor in a perpendicular magnetic field. First, we derive a simple phenomenological
formula for the Nernst coefficient, which naturally explains the giant Nernst
signal due to fluctuating Cooper pairs. The latter signal is shown to be large
even far from the transition and may exceed by orders of magnitude the Fermi liquid
terms. We also present a complete microscopic calculation of the Nernst coefficient
for arbitrary magnetic fields and temperatures, which is based on the standard
definition of heat current vertices. It is shown that the magnitude and the behavior
of the Nernst signal observed experimentally in disordered superconducting films
can be well understood on the basis of superconducting fluctuation theory.
author:
- first_name: Maksym
full_name: Maksym Serbyn
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Mikhail
full_name: Skvortsov, Mikhail A
last_name: Skvortsov
- first_name: Andrei
full_name: Varlamov, Andrei A
last_name: Varlamov
- first_name: Victor
full_name: Galitski, Victor M
last_name: Galitski
citation:
ama: 'Serbyn M, Skvortsov M, Varlamov A, Galitski V. Giant nernst effect due to
fluctuating cooper Pairs in superconductors. In: Vol 1134. American Institute
of Physics; 2009:140-145. doi:10.1063/1.3149485'
apa: Serbyn, M., Skvortsov, M., Varlamov, A., & Galitski, V. (2009). Giant nernst
effect due to fluctuating cooper Pairs in superconductors (Vol. 1134, pp. 140–145).
Presented at the Landau Memorial Conference on Advances in Theoretical Physics,
American Institute of Physics. https://doi.org/10.1063/1.3149485
chicago: Serbyn, Maksym, Mikhail Skvortsov, Andrei Varlamov, and Victor Galitski.
“Giant Nernst Effect Due to Fluctuating Cooper Pairs in Superconductors,” 1134:140–45.
American Institute of Physics, 2009. https://doi.org/10.1063/1.3149485.
ieee: M. Serbyn, M. Skvortsov, A. Varlamov, and V. Galitski, “Giant nernst effect
due to fluctuating cooper Pairs in superconductors,” presented at the Landau Memorial
Conference on Advances in Theoretical Physics, 2009, vol. 1134, pp. 140–145.
ista: Serbyn M, Skvortsov M, Varlamov A, Galitski V. 2009. Giant nernst effect due
to fluctuating cooper Pairs in superconductors. Landau Memorial Conference on
Advances in Theoretical Physics vol. 1134, 140–145.
mla: Serbyn, Maksym, et al. Giant Nernst Effect Due to Fluctuating Cooper Pairs
in Superconductors. Vol. 1134, American Institute of Physics, 2009, pp. 140–45,
doi:10.1063/1.3149485.
short: M. Serbyn, M. Skvortsov, A. Varlamov, V. Galitski, in:, American Institute
of Physics, 2009, pp. 140–145.
conference:
name: Landau Memorial Conference on Advances in Theoretical Physics
date_created: 2018-12-11T11:49:26Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T08:22:17Z
day: '01'
doi: 10.1063/1.3149485
extern: 1
intvolume: ' 1134'
month: '01'
page: 140 - 145
publication_status: published
publisher: American Institute of Physics
publist_id: '6435'
quality_controlled: 0
status: public
title: Giant nernst effect due to fluctuating cooper Pairs in superconductors
type: conference
volume: 1134
year: '2009'
...
---
_id: '7080'
abstract:
- lang: eng
text: We show evidence that a structural martensitic transition is related to significant
changes in the electronic structure, as revealed in thermodynamic measurements
made in high magnetic fields. The effect of the magnetic field is considered unusual
as many influential investigations of martensitic transitions have emphasized
that the structural transitions are primarily lattice dynamical and are driven
by the entropy due to the phonons. We provide a theoretical framework, which can
be used to describe the effect of the magnetic field on the lattice dynamics in
which the field dependence originates from the dielectric constant.
article_processing_charge: No
article_type: original
author:
- first_name: X.-D.
full_name: Yang, X.-D.
last_name: Yang
- first_name: P.S.
full_name: Riseborough, P.S.
last_name: Riseborough
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: R.A.
full_name: Fisher, R.A.
last_name: Fisher
- first_name: C.P.
full_name: Opeil, C.P.
last_name: Opeil
- first_name: T.R.
full_name: Finlayson, T.R.
last_name: Finlayson
- first_name: J.C.
full_name: Cooley, J.C.
last_name: Cooley
- first_name: J.L.
full_name: Smith, J.L.
last_name: Smith
- first_name: P.A.
full_name: Goddard, P.A.
last_name: Goddard
- first_name: A.V.
full_name: Silhanek, A.V.
last_name: Silhanek
- first_name: J.C.
full_name: Lashley, J.C.
last_name: Lashley
citation:
ama: Yang X-D, Riseborough PS, Modic KA, et al. Influence of magnetic fields on
structural martensitic transitions. Philosophical Magazine. 2009;89(22-24):2083-2091.
doi:10.1080/14786430902865518
apa: Yang, X.-D., Riseborough, P. S., Modic, K. A., Fisher, R. A., Opeil, C. P.,
Finlayson, T. R., … Lashley, J. C. (2009). Influence of magnetic fields on structural
martensitic transitions. Philosophical Magazine. Taylor & Francis.
https://doi.org/10.1080/14786430902865518
chicago: Yang, X.-D., P.S. Riseborough, Kimberly A Modic, R.A. Fisher, C.P. Opeil,
T.R. Finlayson, J.C. Cooley, et al. “Influence of Magnetic Fields on Structural
Martensitic Transitions.” Philosophical Magazine. Taylor & Francis,
2009. https://doi.org/10.1080/14786430902865518.
ieee: X.-D. Yang et al., “Influence of magnetic fields on structural martensitic
transitions,” Philosophical Magazine, vol. 89, no. 22–24. Taylor &
Francis, pp. 2083–2091, 2009.
ista: Yang X-D, Riseborough PS, Modic KA, Fisher RA, Opeil CP, Finlayson TR, Cooley
JC, Smith JL, Goddard PA, Silhanek AV, Lashley JC. 2009. Influence of magnetic
fields on structural martensitic transitions. Philosophical Magazine. 89(22–24),
2083–2091.
mla: Yang, X. D., et al. “Influence of Magnetic Fields on Structural Martensitic
Transitions.” Philosophical Magazine, vol. 89, no. 22–24, Taylor &
Francis, 2009, pp. 2083–91, doi:10.1080/14786430902865518.
short: X.-D. Yang, P.S. Riseborough, K.A. Modic, R.A. Fisher, C.P. Opeil, T.R. Finlayson,
J.C. Cooley, J.L. Smith, P.A. Goddard, A.V. Silhanek, J.C. Lashley, Philosophical
Magazine 89 (2009) 2083–2091.
date_created: 2019-11-19T13:48:32Z
date_published: 2009-08-21T00:00:00Z
date_updated: 2023-02-21T16:26:53Z
day: '21'
doi: 10.1080/14786430902865518
extern: '1'
intvolume: ' 89'
issue: 22-24
language:
- iso: eng
month: '08'
oa_version: None
page: 2083-2091
publication: Philosophical Magazine
publication_identifier:
eissn:
- 1478-6443
issn:
- 1478-6435
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
related_material:
record:
- id: '11752'
relation: earlier_version
status: public
status: public
title: Influence of magnetic fields on structural martensitic transitions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 89
year: '2009'
...
---
_id: '7319'
abstract:
- lang: eng
text: In the first paper of this series, an experimental technique for measuring
the current-density distribution with a resolution better than the sub-millimeter
scale of the channel and rib structures in the flow-field plates of polymer electrolyte
fuel cells (PEFCs) was introduced. This method is extended to the determination
of local membrane resistance with the same spatial resolution in the present paper.
The combined measurement of current and resistance allows for investigating the
interaction of mass- and charge-transport processes, which determine the local
rate distribution across the domain of channels and ribs. Therewith, the influence
of relevant operating parameters such as reactant composition, dew points, and
cell compression on local current generation is investigated. The results show
that the distribution of water and oxidant across the channel and rib are the
main reasons for significant current gradients on a scale smaller than a millimeter.
Humidity variation mainly affects the membrane resistance under the channel, while
reactant concentration predominantly influences current generation under the rib-covered
cell area.
article_number: B301
article_processing_charge: No
article_type: original
author:
- first_name: Mathias
full_name: Reum, Mathias
last_name: Reum
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Alexander
full_name: Wokaun, Alexander
last_name: Wokaun
- first_name: Felix N.
full_name: Büchi, Felix N.
last_name: Büchi
citation:
ama: 'Reum M, Freunberger SA, Wokaun A, Büchi FN. Measuring the current distribution
with sub-millimeter resolution in PEFCs: II. Impact of operating parameters. Journal
of The Electrochemical Society. 2009;156(3). doi:10.1149/1.3043422'
apa: 'Reum, M., Freunberger, S. A., Wokaun, A., & Büchi, F. N. (2009). Measuring
the current distribution with sub-millimeter resolution in PEFCs: II. Impact of
operating parameters. Journal of The Electrochemical Society. The Electrochemical
Society. https://doi.org/10.1149/1.3043422'
chicago: 'Reum, Mathias, Stefan Alexander Freunberger, Alexander Wokaun, and Felix
N. Büchi. “Measuring the Current Distribution with Sub-Millimeter Resolution
in PEFCs: II. Impact of Operating Parameters.” Journal of The Electrochemical
Society. The Electrochemical Society, 2009. https://doi.org/10.1149/1.3043422.'
ieee: 'M. Reum, S. A. Freunberger, A. Wokaun, and F. N. Büchi, “Measuring the current
distribution with sub-millimeter resolution in PEFCs: II. Impact of operating
parameters,” Journal of The Electrochemical Society, vol. 156, no. 3. The
Electrochemical Society, 2009.'
ista: 'Reum M, Freunberger SA, Wokaun A, Büchi FN. 2009. Measuring the current
distribution with sub-millimeter resolution in PEFCs: II. Impact of operating
parameters. Journal of The Electrochemical Society. 156(3), B301.'
mla: 'Reum, Mathias, et al. “Measuring the Current Distribution with Sub-Millimeter
Resolution in PEFCs: II. Impact of Operating Parameters.” Journal of The Electrochemical
Society, vol. 156, no. 3, B301, The Electrochemical Society, 2009, doi:10.1149/1.3043422.'
short: M. Reum, S.A. Freunberger, A. Wokaun, F.N. Büchi, Journal of The Electrochemical
Society 156 (2009).
date_created: 2020-01-15T12:21:24Z
date_published: 2009-03-01T00:00:00Z
date_updated: 2021-01-12T08:13:01Z
day: '01'
doi: 10.1149/1.3043422
extern: '1'
intvolume: ' 156'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
issn:
- 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: 'Measuring the current distribution with sub-millimeter resolution in PEFCs:
II. Impact of operating parameters'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 156
year: '2009'
...
---
_id: '752'
abstract:
- lang: eng
text: Set agreement is a fundamental problem in distributed computing in which processes
collectively choose a small subset of values from a larger set of proposals. The
impossibility of fault-tolerant set agreement in asynchronous networks is one
of the seminal results in distributed computing. The complexity of set agreement
in synchronous networks has also been a significant research challenge. Real systems,
however, are neither purely synchronous nor purely asynchronous. Rather, they
tend to alternate between periods of synchrony and periods of asynchrony. In this
paper, we analyze the complexity of set agreement in a "partially synchronous"
setting, presenting the first (asymptotically) tight bound on the complexity of
set agreement in such systems. We introduce a novel technique for simulating,
in fault-prone asynchronous shared memory, executions of an asynchronous and failure-prone
messagepassing system in which some fragments appear synchronous to some processes.
We use this technique to derive a lower bound on the round complexity of set agreement
in a partially synchronous system by a reduction from asynchronous wait-free set
agreement. We also present an asymptotically matching algorithm that relies on
a distributed asynchrony detection mechanism to decide as soon as possible during
periods of synchrony. By relating environments with differing degrees of synchrony,
our simulation technique is of independent interest. In particular, it allows
us to obtain a new lower bound on the complexity of early deciding k-set agreement
complementary to that of [12], and to re-derive the combinatorial topology lower
bound of [13] in an algorithmic way.
acknowledgement: Corentin Travers was supposrted in part by a Sam & Cecilia Neaman
Fellowship
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Seth
full_name: Gilbert, Seth
last_name: Gilbert
- first_name: Rachid
full_name: Guerraoui, Rachid
last_name: Guerraoui
- first_name: Corentin
full_name: Travers, Corentin
last_name: Travers
citation:
ama: 'Alistarh D-A, Gilbert S, Guerraoui R, Travers C. Of choices, failures and
asynchrony: the many faces of set agreement. In: Vol 5878 LNCS. Springer; 2009:943-953.
doi:10.1007/978-3-642-10631-6_95'
apa: 'Alistarh, D.-A., Gilbert, S., Guerraoui, R., & Travers, C. (2009). Of
choices, failures and asynchrony: the many faces of set agreement (Vol. 5878 LNCS,
pp. 943–953). Presented at the ISAAC: International Symposium on Algorithms and
Computation, Springer. https://doi.org/10.1007/978-3-642-10631-6_95'
chicago: 'Alistarh, Dan-Adrian, Seth Gilbert, Rachid Guerraoui, and Corentin Travers.
“Of Choices, Failures and Asynchrony: The Many Faces of Set Agreement,” 5878 LNCS:943–53.
Springer, 2009. https://doi.org/10.1007/978-3-642-10631-6_95.'
ieee: 'D.-A. Alistarh, S. Gilbert, R. Guerraoui, and C. Travers, “Of choices, failures
and asynchrony: the many faces of set agreement,” presented at the ISAAC: International
Symposium on Algorithms and Computation, 2009, vol. 5878 LNCS, pp. 943–953.'
ista: 'Alistarh D-A, Gilbert S, Guerraoui R, Travers C. 2009. Of choices, failures
and asynchrony: the many faces of set agreement. ISAAC: International Symposium
on Algorithms and Computation, LNCS, vol. 5878 LNCS, 943–953.'
mla: 'Alistarh, Dan-Adrian, et al. Of Choices, Failures and Asynchrony: The Many
Faces of Set Agreement. Vol. 5878 LNCS, Springer, 2009, pp. 943–53, doi:10.1007/978-3-642-10631-6_95.'
short: D.-A. Alistarh, S. Gilbert, R. Guerraoui, C. Travers, in:, Springer, 2009,
pp. 943–953.
conference:
name: 'ISAAC: International Symposium on Algorithms and Computation'
date_created: 2018-12-11T11:48:19Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2023-02-23T13:10:05Z
day: '01'
doi: 10.1007/978-3-642-10631-6_95
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 943 - 953
publication_status: published
publisher: Springer
publist_id: '6903'
status: public
title: 'Of choices, failures and asynchrony: the many faces of set agreement'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5878 LNCS
year: '2009'
...
---
_id: '11109'
abstract:
- lang: eng
text: The nuclear envelope (NE) provides a selective barrier between the nuclear
interior and the cytoplasm and constitutes a central component of intracellular
architecture. During mitosis in metazoa, the NE breaks down leading to the complete
mixing of the nuclear content with the cytosol. Interestingly, many NE components
actively participate in mitotic progression. After chromosome segregation, the
NE is reassembled around decondensing chromatin and the nuclear compartment is
reestablished in the daughter cells. Here, we summarize recent progress in deciphering
the molecular mechanisms underlying NE dynamics during cell division.
article_processing_charge: No
article_type: original
author:
- first_name: Ulrike
full_name: Kutay, Ulrike
last_name: Kutay
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Kutay U, Hetzer M. Reorganization of the nuclear envelope during open mitosis.
Current Opinion in Cell Biology. 2008;20(6):669-677. doi:10.1016/j.ceb.2008.09.010
apa: Kutay, U., & Hetzer, M. (2008). Reorganization of the nuclear envelope
during open mitosis. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2008.09.010
chicago: Kutay, Ulrike, and Martin Hetzer. “Reorganization of the Nuclear Envelope
during Open Mitosis.” Current Opinion in Cell Biology. Elsevier, 2008.
https://doi.org/10.1016/j.ceb.2008.09.010.
ieee: U. Kutay and M. Hetzer, “Reorganization of the nuclear envelope during open
mitosis,” Current Opinion in Cell Biology, vol. 20, no. 6. Elsevier, pp.
669–677, 2008.
ista: Kutay U, Hetzer M. 2008. Reorganization of the nuclear envelope during open
mitosis. Current Opinion in Cell Biology. 20(6), 669–677.
mla: Kutay, Ulrike, and Martin Hetzer. “Reorganization of the Nuclear Envelope during
Open Mitosis.” Current Opinion in Cell Biology, vol. 20, no. 6, Elsevier,
2008, pp. 669–77, doi:10.1016/j.ceb.2008.09.010.
short: U. Kutay, M. Hetzer, Current Opinion in Cell Biology 20 (2008) 669–677.
date_created: 2022-04-07T07:55:00Z
date_published: 2008-12-01T00:00:00Z
date_updated: 2024-10-14T11:29:10Z
day: '01'
doi: 10.1016/j.ceb.2008.09.010
extern: '1'
external_id:
pmid:
- '18938243'
intvolume: ' 20'
issue: '6'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa_version: None
page: 669-677
pmid: 1
publication: Current Opinion in Cell Biology
publication_identifier:
issn:
- 0955-0674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reorganization of the nuclear envelope during open mitosis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2008'
...
---
_id: '11110'
abstract:
- lang: eng
text: Nuclear pore complexes are large aqueous channels that penetrate the nuclear
envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently,
these macromolecular complexes were viewed as static structures, the only function
of which was to control the molecular trafficking between the two compartments.
It has now become evident that this simplistic scenario is inaccurate and that
nuclear pore complexes are highly dynamic multiprotein assemblies involved in
diverse cellular processes ranging from the organization of the cytoskeleton to
gene expression. In this review, we discuss the most recent developments in the
nuclear-pore-complex field, focusing on the assembly, disassembly, maintenance
and function of this macromolecular structure.
article_processing_charge: No
article_type: review
author:
- first_name: Maximiliano A.
full_name: D’Angelo, Maximiliano A.
last_name: D’Angelo
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: D’Angelo MA, Hetzer M. Structure, dynamics and function of nuclear pore complexes.
Trends in Cell Biology. 2008;18(10):456-466. doi:10.1016/j.tcb.2008.07.009
apa: D’Angelo, M. A., & Hetzer, M. (2008). Structure, dynamics and function
of nuclear pore complexes. Trends in Cell Biology. Elsevier. https://doi.org/10.1016/j.tcb.2008.07.009
chicago: D’Angelo, Maximiliano A., and Martin Hetzer. “Structure, Dynamics and Function
of Nuclear Pore Complexes.” Trends in Cell Biology. Elsevier, 2008. https://doi.org/10.1016/j.tcb.2008.07.009.
ieee: M. A. D’Angelo and M. Hetzer, “Structure, dynamics and function of nuclear
pore complexes,” Trends in Cell Biology, vol. 18, no. 10. Elsevier, pp.
456–466, 2008.
ista: D’Angelo MA, Hetzer M. 2008. Structure, dynamics and function of nuclear pore
complexes. Trends in Cell Biology. 18(10), 456–466.
mla: D’Angelo, Maximiliano A., and Martin Hetzer. “Structure, Dynamics and Function
of Nuclear Pore Complexes.” Trends in Cell Biology, vol. 18, no. 10, Elsevier,
2008, pp. 456–66, doi:10.1016/j.tcb.2008.07.009.
short: M.A. D’Angelo, M. Hetzer, Trends in Cell Biology 18 (2008) 456–466.
date_created: 2022-04-07T07:55:10Z
date_published: 2008-10-01T00:00:00Z
date_updated: 2024-10-14T11:29:21Z
day: '01'
doi: 10.1016/j.tcb.2008.07.009
extern: '1'
external_id:
pmid:
- '18786826'
intvolume: ' 18'
issue: '10'
keyword:
- Cell Biology
language:
- iso: eng
month: '10'
oa_version: None
page: 456-466
pmid: 1
publication: Trends in Cell Biology
publication_identifier:
issn:
- 0962-8924
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure, dynamics and function of nuclear pore complexes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2008'
...
---
_id: '11111'
abstract:
- lang: eng
text: During mitosis in metazoans, segregated chromosomes become enclosed by the
nuclear envelope (NE), a double membrane that is continuous with the endoplasmic
reticulum (ER). Recent in vitro data suggest that NE formation occurs by chromatin-mediated
reorganization of the tubular ER; however, the basic principles of such a membrane-reshaping
process remain uncharacterized. Here, we present a quantitative analysis of nuclear
membrane assembly in mammalian cells using time-lapse microscopy. From the initial
recruitment of ER tubules to chromatin, the formation of a membrane-enclosed,
transport-competent nucleus occurs within ∼12 min. Overexpression of the ER tubule-forming
proteins reticulon 3, reticulon 4, and DP1 inhibits NE formation and nuclear expansion,
whereas their knockdown accelerates nuclear assembly. This suggests that the transition
from membrane tubules to sheets is rate-limiting for nuclear assembly. Our results
provide evidence that ER-shaping proteins are directly involved in the reconstruction
of the nuclear compartment and that morphological restructuring of the ER is the
principal mechanism of NE formation in vivo.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel J.
full_name: Anderson, Daniel J.
last_name: Anderson
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Anderson DJ, Hetzer M. Reshaping of the endoplasmic reticulum limits the rate
for nuclear envelope formation. Journal of Cell Biology. 2008;182(5):911-924.
doi:10.1083/jcb.200805140
apa: Anderson, D. J., & Hetzer, M. (2008). Reshaping of the endoplasmic reticulum
limits the rate for nuclear envelope formation. Journal of Cell Biology.
Rockefeller University Press. https://doi.org/10.1083/jcb.200805140
chicago: Anderson, Daniel J., and Martin Hetzer. “Reshaping of the Endoplasmic Reticulum
Limits the Rate for Nuclear Envelope Formation.” Journal of Cell Biology.
Rockefeller University Press, 2008. https://doi.org/10.1083/jcb.200805140.
ieee: D. J. Anderson and M. Hetzer, “Reshaping of the endoplasmic reticulum limits
the rate for nuclear envelope formation,” Journal of Cell Biology, vol.
182, no. 5. Rockefeller University Press, pp. 911–924, 2008.
ista: Anderson DJ, Hetzer M. 2008. Reshaping of the endoplasmic reticulum limits
the rate for nuclear envelope formation. Journal of Cell Biology. 182(5), 911–924.
mla: Anderson, Daniel J., and Martin Hetzer. “Reshaping of the Endoplasmic Reticulum
Limits the Rate for Nuclear Envelope Formation.” Journal of Cell Biology,
vol. 182, no. 5, Rockefeller University Press, 2008, pp. 911–24, doi:10.1083/jcb.200805140.
short: D.J. Anderson, M. Hetzer, Journal of Cell Biology 182 (2008) 911–924.
date_created: 2022-04-07T07:55:23Z
date_published: 2008-09-08T00:00:00Z
date_updated: 2024-10-14T11:29:29Z
day: '08'
doi: 10.1083/jcb.200805140
extern: '1'
external_id:
pmid:
- '18779370'
intvolume: ' 182'
issue: '5'
keyword:
- Cell Biology
language:
- iso: eng
month: '09'
oa_version: None
page: 911-924
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope
formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 182
year: '2008'
...