Schauer, Alexandra, Kornelija Pranjic-Ferscha, Robert Hauschild, and Carl-Philipp J Heisenberg. “Robust Axis Elongation by Nodal-Dependent Restriction of BMP Signaling.”https://doi.org/10.1242/dev.202316__Development. The Company of Biologists, 2024.https://doi.org/10.1242/dev.202316 .

Hauschild, Robert. “Matlab Script for Analysis of Clone Dispersal.”https://doi.org/10.15479/AT:ISTA:14926__ISTA, 2024.https://doi.org/10.15479/AT:ISTA:14926 .

Zens, Bettina, Florian Fäßler, Jesse Hansen, Robert Hauschild, Julia Datler, Victor-Valentin Hodirnau, Vanessa Zheden, Jonna H Alanko, Michael K Sixt, and Florian KM Schur. “Lift-out Cryo-FIBSEM and Cryo-ET Reveal the Ultrastructural Landscape of Extracellular Matrix.”https://doi.org/10.1083/jcb.202309125__Journal of Cell Biology. Rockefeller University Press, 2024.https://doi.org/10.1083/jcb.202309125 .

Huljev, Karla, Shayan Shamipour, Diana C Nunes Pinheiro, Friedrich Preusser, Irene Steccari, Christoph M Sommer, Suyash Naik, and Carl-Philipp J Heisenberg. “A Hydraulic Feedback Loop between Mesendoderm Cell Migration and Interstitial Fluid Relocalization Promotes Embryonic Axis Formation in Zebrafish.”https://doi.org/10.1016/j.devcel.2023.02.016__Developmental Cell. Elsevier, 2023.https://doi.org/10.1016/j.devcel.2023.02.016 .

Zavadakova, Anna, Lucie Vistejnova, Tereza Belinova, Filip Tichanek, Dagmar Bilikova, and Peter R. Mouton. “Novel Stereological Method for Estimation of Cell Counts in 3D Collagen Scaffolds.”https://doi.org/10.1038/s41598-023-35162-z__Scientific Reports. Springer Nature, 2023.https://doi.org/10.1038/s41598-023-35162-z .

Kroll, Janina, Robert Hauschild, Arthur Kuznetcov, Kasia Stefanowski, Monika D. Hermann, Jack Merrin, Lubuna B Shafeek, Annette Müller-Taubenberger, and Jörg Renkawitz. “Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration.”https://doi.org/10.15252/embj.2023114557__EMBO Journal. Embo Press, 2023.https://doi.org/10.15252/embj.2023114557 .

Cikes, Domagoj, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc, Michael Orthofer, Rebecca Yarwood, et al. “PCY-Regulated Lipid Biosynthesis Is Critical to Muscle Health and Ageing.”https://doi.org/10.1038/s42255-023-00766-2__Nature Metabolism. Springer Nature, 2023.https://doi.org/10.1038/s42255-023-00766-2 .

Méhes, Elod, Enys Mones, Máté Varga, Áron Zsigmond, Beáta Biri-Kovács, László Nyitray, Vanessa Barone, Gabriel Krens, Carl-Philipp J Heisenberg, and Tamás Vicsek. “D Cell Segregation Geometry and Dynamics Are Governed by Tissue Surface Tension Regulation.”https://doi.org/10.1038/s42003-023-05181-7__Communications Biology. Springer Nature, 2023.https://doi.org/10.1038/s42003-023-05181-7 .

Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Julia Lyudchik, Donglai Wei, Zudi Lin, Jake Watson, et al. “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.”https://doi.org/10.1038/s41592-023-01936-6__Nature Methods. Springer Nature, 2023.https://doi.org/10.1038/s41592-023-01936-6 .

Westerich, Kim Joana, Katsiaryna Tarbashevich, Jan Schick, Antra Gupta, Mingzhao Zhu, Kenneth Hull, Daniel Romo, et al. “Spatial Organization and Function of RNA Molecules within Phase-Separated Condensates in Zebrafish Are Controlled by Dnd1.”https://doi.org/10.1016/j.devcel.2023.06.009__Developmental Cell. Elsevier, 2023.https://doi.org/10.1016/j.devcel.2023.06.009 .

Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.”https://doi.org/10.1038/s41587-023-01911-8__Nature Biotechnology. Springer Nature, 2023.https://doi.org/10.1038/s41587-023-01911-8 .

Mondal, Soumyadip, Rajesh B Jethwa, Bhargavi Pant, Robert Hauschild, and Stefan Alexander Freunberger. “Singlet Oxygen in Non-Aqueous Oxygen Redox: Direct Spectroscopic Evidence for Formation Pathways and Reliability of Chemical Probes.”https://doi.org/10.1039/d3fd00088e__Faraday Discussions. Royal Society of Chemistry, 2023.https://doi.org/10.1039/d3fd00088e .

Assen, Frank P, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter Kaufmann, Tommaso Costanzo, et al. “Multitier Mechanics Control Stromal Adaptations in Swelling Lymph Nodes.”https://doi.org/10.1038/s41590-022-01257-4__Nature Immunology. Springer Nature, 2022.https://doi.org/10.1038/s41590-022-01257-4 .

Slovakova, Jana, Mateusz K Sikora, Feyza N Arslan, Silvia Caballero Mancebo, Gabriel Krens, Walter Kaufmann, Jack Merrin, and Carl-Philipp J Heisenberg. “Tension-Dependent Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion in Zebrafish Germ-Layer Progenitor Cells.”https://doi.org/10.1073/pnas.2122030119__Proceedings of the National Academy of Sciences of the United States of America. Proceedings of the National Academy of Sciences, 2022.https://doi.org/10.1073/pnas.2122030119 .

Johnson, Alexander J, Walter Kaufmann, Christoph M Sommer, Tommaso Costanzo, Dana A. Dahhan, Sebastian Y. Bednarek, and Jií Friml. “Three-Dimensional Visualization of Planta Clathrin-Coated Vesicles at Ultrastructural Resolution.”https://doi.org/10.1016/j.molp.2022.09.003__Molecular Plant. Elsevier, 2022.https://doi.org/10.1016/j.molp.2022.09.003 .

Weier, Ann-Kathrin, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliska Miková, Robert Hauschild, Lili Zhang, et al. “Multiple Centrosomes Enhance Migration and Immune Cell Effector Functions of Mature Dendritic Cells.”https://doi.org/10.1083/jcb.202107134__Journal of Cell Biology. Rockefeller University Press, 2022.https://doi.org/10.1083/jcb.202107134 .

Li, Hongjiang, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda, Satoshi Naramoto, Krzysztof T Wabnik, et al. “Cellular Requirements for PIN Polar Cargo Clustering in Arabidopsis Thaliana.”https://doi.org/10.1111/nph.16887__New Phytologist. Wiley, 2021.https://doi.org/10.1111/nph.16887 .

Vaahtomeri, Kari, Christine Moussion, Robert Hauschild, and Michael K Sixt. “Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium.”https://doi.org/10.3389/fimmu.2021.630002__Frontiers in Immunology. Frontiers, 2021.https://doi.org/10.3389/fimmu.2021.630002 .

Gast, Matthieu, Nicole P. Kadzioch, Doreen Milius, Francesco Origgi, and Philippe Plattet. “Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.”https://doi.org/10.1128/mSphere.01024-20__MSphere. American Society for Microbiology, 2021.https://doi.org/10.1128/mSphere.01024-20 .

Zisis, Themistoklis, Jan Schwarz, Miriam Balles, Maibritt Kretschmer, Maria Nemethova, Remy P Chait, Robert Hauschild, et al. “Sequential and Switchable Patterning for Studying Cellular Processes under Spatiotemporal Control.”https://doi.org/10.1021/acsami.1c09850__ACS Applied Materials and Interfaces. American Chemical Society, 2021.https://doi.org/10.1021/acsami.1c09850 .

Nelson, Glyn, Ulrike Boehm, Steve Bagley, Peter Bajcsy, Johanna Bischof, Claire M. Brown, Aurélien Dauphin, et al. “QUAREP-LiMi: A Community-Driven Initiative to Establish Guidelines for Quality Assessment and Reproducibility for Instruments and Images in Light Microscopy.”https://doi.org/10.1111/jmi.13041__Journal of Microscopy. Wiley, 2021.https://doi.org/10.1111/jmi.13041 .

Bajaj, Sunanjay, Joshua A. Bagley, Christoph M Sommer, Abel Vertesy, Sakurako Nagumo Wong, Veronica Krenn, Julie Lévi-Strauss, and Juergen A. Knoblich. “Neurotransmitter Signaling Regulates Distinct Phases of Multimodal Human Interneuron Migration.”https://doi.org/10.15252/embj.2021108714__EMBO Journal. Embo Press, 2021.https://doi.org/10.15252/embj.2021108714 .

Pranger, Christina L., Judit Singer, Verena K. Köhler, Isabella PaliSchöll, Alessandro Fiocchi, Sophia N. Karagiannis, Olatz Zenarruzabeitia, Francisco Borrego, and Erika JensenJarolim. “PIPEcloned Human IgE and Ig Antibodies: New Tools for Investigating Cow’s Milk Allergy and Tolerance.”https://doi.org/10.1111/all.14604__Allergy. Wiley, 2021.https://doi.org/10.1111/all.14604 .

Valentini, Marco, Fernando Peñaranda, Andrea C Hofmann, Matthias Brauns, Robert Hauschild, Peter Krogstrup, Pablo San-Jose, Elsa Prada, Ramón Aguado, and Georgios Katsaros. “Nontopological Zero-Bias Peaks in Full-Shell Nanowires Induced by Flux-Tunable Andreev States.”https://doi.org/10.1126/science.abf1513__Science. American Association for the Advancement of Science, 2021.https://doi.org/10.1126/science.abf1513 .

Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi A Dimchev, Armel Nicolas, Christoph M Sommer, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.”https://doi.org/10.1038/s41467-021-23123-x__Nature Communications. Springer Nature, 2021.https://doi.org/10.1038/s41467-021-23123-x .

Gelová, Zuzana, Michelle C Gallei, Markéta Pernisová, Géraldine Brunoud, Xixi Zhang, Matous Glanc, Lanxin Li, et al. “Developmental Roles of Auxin Binding Protein 1 in Arabidopsis Thaliana.”https://doi.org/10.1016/j.plantsci.2020.110750__Plant Science. Elsevier, 2021.https://doi.org/10.1016/j.plantsci.2020.110750 .

Hauschild, Robert. “Amplified Centrosomes in Dendritic Cells Promote Immune Cell Effector Functions.”https://doi.org/10.15479/AT:ISTA:8181__IST Austria, 2020.https://doi.org/10.15479/AT:ISTA:8181 .

Hauschild, Robert. “RGtracker.”https://doi.org/10.15479/AT:ISTA:8294__IST Austria, 2020.https://doi.org/10.15479/AT:ISTA:8294 .

Kopf, Aglaja, Jörg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry Tedford, Jack Merrin, Oliver Thorn-Seshold, et al. “Microtubules Control Cellular Shape and Coherence in Amoeboid Migrating Cells.”https://doi.org/10.1083/jcb.201907154__The Journal of Cell Biology. Rockefeller University Press, 2020.https://doi.org/10.1083/jcb.201907154 .

Schauer, Alexandra, Diana C Nunes Pinheiro, Robert Hauschild, and Carl-Philipp J Heisenberg. “Zebrafish Embryonic Explants Undergo Genetically Encoded Self-Assembly.”https://doi.org/10.7554/elife.55190__ELife. eLife Sciences Publications, 2020.https://doi.org/10.7554/elife.55190 .

Singer, Judit, Josef Singer, and Erika Jensen-Jarolim. “Precision Medicine in Clinical Oncology: The Journey from IgG Antibody to IgE.”https://doi.org/10.1097/ACI.0000000000000637__Current Opinion in Allergy and Clinical Immunology. Wolters Kluwer, 2020.https://doi.org/10.1097/ACI.0000000000000637 .

Slovakova, Jana, Mateusz K Sikora, Silvia Caballero Mancebo, Gabriel Krens, Walter Kaufmann, Karla Huljev, and Carl-Philipp J Heisenberg. “Tension-Dependent Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion.”https://doi.org/10.1101/2020.11.20.391284__BioRxiv. Cold Spring Harbor Laboratory, 2020.https://doi.org/10.1101/2020.11.20.391284 .

Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan, Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental Topography.”https://doi.org/10.1038/s41586-020-2283-z__Nature. Springer Nature, 2020.https://doi.org/10.1038/s41586-020-2283-z .

Truckenbrodt, Sven M, Christoph M Sommer, Silvio O Rizzoli, and Johann G Danzl. “A Practical Guide to Optimization inhttps://doi.org/10.1038/s41596-018-0117-3__Expansion Microscopy.”https://doi.org/10.1038/s41596-018-0117-3__Nature Protocols. Nature Publishing Group, 2019.https://doi.org/10.1038/s41596-018-0117-3 .

Fenu, M., T. Bettermann, C. Vogl, Nasser Darwish-Miranda, J. Schramel, F. Jenner, and I. Ribitsch. “A Novel Magnet-Based Scratch Method for Standardisation of Wound-Healing Assays.”https://doi.org/10.1038/s41598-019-48930-7__Scientific Reports. Springer Nature, 2019.https://doi.org/10.1038/s41598-019-48930-7 .

Mckenzie, Catherine, Miroslava Spanova, Alexander J Johnson, Stephanie Kainrath, Vanessa Zheden, Harald H. Sitte, and Harald L Janovjak. “Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.”https://doi.org/10.1016/j.jneumeth.2018.11.018__Journal of Neuroscience Methods. Elsevier, 2019.https://doi.org/10.1016/j.jneumeth.2018.11.018 .

Goudarzi, Mohammad, Aleix Boquet-Pujadas, Jean Christophe Olivo-Marin, and Erez Raz. “Fluid Dynamics during Bleb Formation in Migrating Cells in Vivo.”https://doi.org/10.1371/journal.pone.0212699__PLOS ONE. Public Library of Science, 2019.https://doi.org/10.1371/journal.pone.0212699 .

Renkawitz, Jörg, Aglaja Kopf, Julian A Stopp, Ingrid de Vries, Meghan K. Driscoll, Jack Merrin, Robert Hauschild, et al. “Nuclear Positioning Facilitates Amoeboid Migration along the Path of Least Resistance.”https://doi.org/10.1038/s41586-019-1087-5__Nature. Springer Nature, 2019.https://doi.org/10.1038/s41586-019-1087-5 .

Ratheesh, Aparna, Julia Bicher, Michael Smutny, Jana Veselá, Ekaterina Papusheva, Gabriel Krens, Walter Kaufmann, Attila György, Alessandra M Casano, and Daria E Siekhaus. “Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration.”https://doi.org/10.1016/j.devcel.2018.04.002__Developmental Cell. Elsevier, 2018.https://doi.org/10.1016/j.devcel.2018.04.002 .

Leithner, Alexander F, Jörg Renkawitz, Ingrid de Vries, Robert Hauschild, Hans Haecker, and Michael K Sixt. “Fast and Efficient Genetic Engineering of Hematopoietic Precursor Cells for the Study of Dendritic Cell Migration.”https://doi.org/10.1002/eji.201747358__European Journal of Immunology. Wiley-Blackwell, 2018.https://doi.org/10.1002/eji.201747358 .

Brown, Markus, Louise Johnson, Dario Leone, Peter Májek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, et al. “Lymphatic Exosomes Promote Dendritic Cell Migration along Guidance Cues.”https://doi.org/10.1083/jcb.201612051__Journal of Cell Biology. Rockefeller University Press, 2018.https://doi.org/10.1083/jcb.201612051 .

Hons, Miroslav, Aglaja Kopf, Robert Hauschild, Alexander F Leithner, Florian R Gärtner, Jun Abe, Jörg Renkawitz, Jens Stein, and Michael K Sixt. “Chemokines and Integrins Independently Tune Actin Flow and Substrate Friction during Intranodal Migration of T Cells.”https://doi.org/10.1038/s41590-018-0109-z__Nature Immunology. Nature Publishing Group, 2018.https://doi.org/10.1038/s41590-018-0109-z .

Li, Lanxin, Gabriel Krens, Matyas Fendrych, and Jií Friml. “Real-Time Analysis of Auxin Response, Cell Wall PH and Elongation in Arabidopsis Thaliana Hypocotyls.”https://doi.org/10.21769/BioProtoc.2685__Bio-Protocol. Bio-protocol, 2018.https://doi.org/10.21769/BioProtoc.2685 .

Vaahtomeri, Kari, Markus Brown, Robert Hauschild, Ingrid de Vries, Alexander F Leithner, Matthias Mehling, Walter Kaufmann, and Michael K Sixt. “Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.”https://doi.org/10.1016/j.celrep.2017.04.027__Cell Reports. Cell Press, 2017.https://doi.org/10.1016/j.celrep.2017.04.027 .

Schwarz, Jan, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid de Vries, Alexander F Leithner, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.”https://doi.org/10.1016/j.cub.2017.04.004__Current Biology. Cell Press, 2017.https://doi.org/10.1016/j.cub.2017.04.004 .

Mueller, Jan, Gregory Szep, Maria Nemethova, Ingrid de Vries, Arnon Lieber, Christoph Winkler, Karsten Kruse, et al. “Load Adaptation of Lamellipodial Actin Networks.”https://doi.org/10.1016/j.cell.2017.07.051__Cell. Cell Press, 2017.https://doi.org/10.1016/j.cell.2017.07.051 .

Bergmiller, Tobias, Anna M Andersson, Kathrin Tomasek, Enrique Balleza, Daniel Kiviet, Robert Hauschild, Gasper Tkadik, and Calin C Guet. “Biased Partitioning of the Multidrug Efflux Pump AcrAB TolC Underlies Long Lived Phenotypic Heterogeneity.”https://doi.org/10.1126/science.aaf4762__Science. American Association for the Advancement of Science, 2017.https://doi.org/10.1126/science.aaf4762 .

Wangenheim, Daniel von, Robert Hauschild, Matyas Fendrych, Vanessa Barone, Eva Benková, and Jií Friml. “Live Tracking of Moving Samples in Confocal Microscopy for Vertically Grown Roots.”https://doi.org/10.7554/eLife.26792__ELife. eLife Sciences Publications, 2017.https://doi.org/10.7554/eLife.26792 .

Wangenheim, Daniel von, Robert Hauschild, and Jií Friml. “Light Sheet Fluorescence Microscopy of Plant Roots Growing on the Surface of a Gel.”https://doi.org/10.3791/55044__Journal of Visualized Experiments JoVE. Journal of Visualized Experiments, 2017.https://doi.org/10.3791/55044 .

Krens, Gabriel, Jim Veldhuis, Vanessa Barone, Daniel Capek, Jean-Léon Maître, Wayne Brodland, and Carl-Philipp J Heisenberg. “Interstitial Fluid Osmolarity Modulates the Action of Differential Tissue Surface Tension in Progenitor Cell Segregation during Gastrulation.”https://doi.org/10.1242/dev.144964__Development. Company of Biologists, 2017.https://doi.org/10.1242/dev.144964 .

Smutny, Michael, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht, Daniel Capek, Martin Behrndt, et al. “Friction Forces Position the Neural Anlage.”https://doi.org/10.1038/ncb3492__Nature Cell Biology. Nature Publishing Group, 2017.https://doi.org/10.1038/ncb3492 .

Schwarz, Jan, Veronika Bierbaum, Jack Merrin, Tino Frank, Robert Hauschild, Mark Tobias Bollenbach, Savaf Tay, Michael K Sixt, and Matthias Mehling. “A Microfluidic Device for Measuring Cell Migration towards Substrate Bound and Soluble Chemokine Gradients.”https://doi.org/10.1038/srep36440__Scientific Reports. Nature Publishing Group, 2016.https://doi.org/10.1038/srep36440 .

Leithner, Alexander F, Alexander Eichner, Jan Müller, Anne Reversat, Markus Brown, Jan Schwarz, Jack Merrin, et al. “Diversified Actin Protrusions Promote Environmental Exploration but Are Dispensable for Locomotion of Leukocytes.”https://doi.org/10.1038/ncb3426__Nature Cell Biology. Nature Publishing Group, 2016.https://doi.org/10.1038/ncb3426 .

Chen, Xu, Laurie Grandont, Hongjiang Li, Robert Hauschild, Sébastien Paque, Anas Abuzeineh, Hana Rakusova, Eva Benková, Catherine Perrot Rechenmann, and Jií Friml. “Inhibition of Cell Expansion by Rapid AB-Mediated Auxin Effect on Microtubules.”https://doi.org/10.1038/nature13889__Nature. Nature Publishing Group, 2014.https://doi.org/10.1038/nature13889 .

Gao, Peng, Maria P Postiglione, Teresa Krieger, Luisirene Hernandez, Chao Wang, Zhi Han, Carmen Streicher, et al. “Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex.”https://doi.org/10.1016/j.cell.2014.10.027__Cell. Cell Press, 2014.https://doi.org/10.1016/j.cell.2014.10.027 .

Weber, Michele, Robert Hauschild, Jan Schwarz, Christine Moussion, Ingrid de Vries, Daniel Legler, Sanjiv Luther, Mark Tobias Bollenbach, and Michael K Sixt. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.”https://doi.org/10.1126/science.1228456__Science. American Association for the Advancement of Science, 2013.https://doi.org/10.1126/science.1228456 .

Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild, Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.”https://doi.org/10.1126/science.1224143__Science. American Association for the Advancement of Science, 2012.https://doi.org/10.1126/science.1224143 .

Sommer, Christoph M, Christoph Straehle, Ullrich Köthe, and Fred A. Hamprecht. “Ilastik: Interactive Learning and Segmentation Toolkit.”https://doi.org/10.1109/isbi.2011.5872394__In 2011 IEEE International Symposium on Biomedical Imaging: From Nano to Micro. Institute of Electrical and Electronics Engineers, 2011.https://doi.org/10.1109/isbi.2011.5872394 .

Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.”https://doi.org/10.1038/emboj.2010.182__EMBO Journal. Wiley-Blackwell, 2010.https://doi.org/10.1038/emboj.2010.182 .