Nikolic, Nela, Frank Schreiber, Alma Dal Co, Daniel Kiviet, Tobias Bergmiller, Sten Littmann, Marcel Kuypers, and Martin Ackermann. “Supplementary Methods.”https://doi.org/10.1371/journal.pgen.1007122.s016__Public Library of Science, 2017.https://doi.org/10.1371/journal.pgen.1007122.s016 .

Lukacisinova, Marta, Sebastian Novak, and Tiago Paixao. “Heuristic Prediction for Multiple Stresses.”https://doi.org/10.1371/journal.pcbi.1005609.s003__Public Library of Science, 2017.https://doi.org/10.1371/journal.pcbi.1005609.s003 .

Lukacisinova, Marta, Sebastian Novak, and Tiago Paixao. “Resistance Frequencies for Different Combination Strategies.”https://doi.org/10.1371/journal.pcbi.1005609.s004__Public Library of Science, 2017.https://doi.org/10.1371/journal.pcbi.1005609.s004 .

Nikolic, Nela, Frank Schreiber, Alma Dal Co, Daniel Kiviet, Tobias Bergmiller, Sten Littmann, Marcel Kuypers, and Martin Ackermann. “Source Data for Figures and Tables.”https://doi.org/10.1371/journal.pgen.1007122.s018__Public Library of Science, 2017.https://doi.org/10.1371/journal.pgen.1007122.s018 .

Pleska, Maros, and Calin C Guet. “Effects of Mutations in Phage Restriction Sites during Escape from Restriction–Modification.”https://doi.org/10.1098/rsbl.2017.0646__Biology Letters. The Royal Society, 2017.https://doi.org/10.1098/rsbl.2017.0646 .

Pleska, Maros. “Biology of Restriction-Modification Systems at the Single-Cell and Population Level.”https://doi.org/10.15479/AT:ISTA:th_916__Institute of Science and Technology Austria, 2017.https://doi.org/10.15479/AT:ISTA:th_916 .

Giacobbe, Mirco, Calin C Guet, Ashutosh Gupta, Thomas A Henzinger, Tiago Paixao, and Tatjana Petrov. “Model Checking the Evolution of Gene Regulatory Networks.”https://doi.org/10.1007/s00236-016-0278-x__Acta Informatica. Springer, 2017.https://doi.org/10.1007/s00236-016-0278-x .

Paixao, Tiago, Jorge Pérez Heredia, Dirk Sudholt, and Barbora Trubenova. “Towards a Runtime Comparison of Natural and Artificial Evolution.”https://doi.org/10.1007/s00453-016-0212-1__Algorithmica. Springer, 2017.https://doi.org/10.1007/s00453-016-0212-1 .

Fang, Chong, Anna A Nagy-Staron, Martin Grafe, Ralf Heermann, Kirsten Jung, Susanne Gebhard, and Thorsten Mascher. “Insulation and Wiring Specificity of BceR like Response Regulators and Their Target Promoters in Bacillus Subtilis.”https://doi.org/10.1111/mmi.13597__Molecular Microbiology. Wiley-Blackwell, 2017.https://doi.org/10.1111/mmi.13597 .

Lagator, Mato, Tiago Paixao, Nicholas H Barton, Jonathan P Bollback, and Calin C Guet. “On the Mechanistic Nature of Epistasis in a Canonical Cis-Regulatory Element.”https://doi.org/10.7554/eLife.25192__ELife. eLife Sciences Publications, 2017.https://doi.org/10.7554/eLife.25192 .

Lang, Moritz, and Eduardo Sontag. “Zeros of Nonlinear Systems with Input Invariances.”https://doi.org/10.1016/j.automatica.2017.03.030__Automatica. International Federation of Automatic Control, 2017.https://doi.org/10.1016/j.automatica.2017.03.030 .

Bergmiller, Tobias, Anna M Andersson, Kathrin Tomasek, Enrique Balleza, Daniel Kiviet, Robert Hauschild, Gasper Tkadik, and Calin C Guet. “Biased Partitioning of the Multidrug Efflux Pump AcrAB TolC Underlies Long Lived Phenotypic Heterogeneity.”https://doi.org/10.1126/science.aaf4762__Science. American Association for the Advancement of Science, 2017.https://doi.org/10.1126/science.aaf4762 .

Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel, and Harald L Janovjak. “Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains.”https://doi.org/10.1002/anie.201611998__Angewandte Chemie - International Edition. Wiley-Blackwell, 2017.https://doi.org/10.1002/anie.201611998 .

Steinrück, Magdalena, and Calin C Guet. “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.”https://doi.org/10.7554/eLife.25100__ELife. eLife Sciences Publications, 2017.https://doi.org/10.7554/eLife.25100 .

Lukacisinova, Marta, Sebastian Novak, and Tiago Paixao. “Stress Induced Mutagenesis: Stress Diversity Facilitates the Persistence of Mutator Genes.”https://doi.org/10.1371/journal.pcbi.1005609__PLoS Computational Biology. Public Library of Science, 2017.https://doi.org/10.1371/journal.pcbi.1005609 .

Barone, Vanessa, Moritz Lang, Gabriel Krens, Saurabh Pradhan, Shayan Shamipour, Keisuke Sako, Mateusz K Sikora, Calin C Guet, and Carl-Philipp J Heisenberg. “An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.”https://doi.org/10.1016/j.devcel.2017.09.014__Developmental Cell. Cell Press, 2017.https://doi.org/10.1016/j.devcel.2017.09.014 .

Gnügge, Robert, Lekshmi Dharmarajan, Moritz Lang, and Jörg Stelling. “An Orthogonal Permease–Inducer–Repressor Feedback Loop Shows Bistability.”https://doi.org/10.1021/acssynbio.6b00013__ACS Synthetic Biology. American Chemical Society, 2016.https://doi.org/10.1021/acssynbio.6b00013 .

Lang, Moritz, and Jörg Stelling. “Modular Parameter Identification of Biomolecular Networks.”https://doi.org/10.1137/15M103306X__SIAM Journal on Scientific Computing. Society for Industrial and Applied Mathematics , 2016.https://doi.org/10.1137/15M103306X .

Miki, Gregor, Alex Stoll, Joe Bevirt, Rok Grah, and Mark Moore. “Fuselage Boundary Layer Ingestion Propulsion Applied to a Thin Haul Commuter Aircraft for Optimal Efficiency,”https://doi.org/10.2514/6.2016-3764__1–19. AIAA, 2016.https://doi.org/10.2514/6.2016-3764 .

Stone, Laura, Michael Baym, Tami Lieberman, Remy P Chait, Jon Clardy, and Roy Kishony. “Compounds That Select against the Tetracycline-Resistance Efflux Pump.”https://doi.org/10.1038/nchembio.2176__Nature Chemical Biology. Nature Publishing Group, 2016.https://doi.org/10.1038/nchembio.2176 .