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125 Publications
2022 | Journal Article | IST-REx-ID: 10736 | 
Predicting bacterial promoter function and evolution from random sequences
M. Lagator, S. Sarikas, M. Steinrueck, D. Toledo-Aparicio, J.P. Bollback, C.C. Guet, G. Tkačik, ELife 11 (2022).
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| DOI
| PubMed | Europe PMC
M. Lagator, S. Sarikas, M. Steinrueck, D. Toledo-Aparicio, J.P. Bollback, C.C. Guet, G. Tkačik, ELife 11 (2022).
2022 | Journal Article | IST-REx-ID: 10939 |
Parameter inference for stochastic biochemical models from perturbation experiments parallelised at the single cell level
A. Davidović, R.P. Chait, G. Batt, J. Ruess, PLoS Computational Biology 18 (2022).
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A. Davidović, R.P. Chait, G. Batt, J. Ruess, PLoS Computational Biology 18 (2022).
2022 | Journal Article | IST-REx-ID: 11339 |
Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells
G. Glover, M. Voliotis, U. Łapińska, B.M. Invergo, D. Soanes, P. O’Neill, K. Moore, N. Nikolic, P. Petrov, D.S. Milner, S. Roy, K. Heesom, T.A. Richards, K. Tsaneva-Atanasova, S. Pagliara, Communications Biology 5 (2022).
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| PubMed | Europe PMC
G. Glover, M. Voliotis, U. Łapińska, B.M. Invergo, D. Soanes, P. O’Neill, K. Moore, N. Nikolic, P. Petrov, D.S. Milner, S. Roy, K. Heesom, T.A. Richards, K. Tsaneva-Atanasova, S. Pagliara, Communications Biology 5 (2022).
2022 | Journal Article | IST-REx-ID: 11713 |
Quantifying heterologous gene expression during ectopic MazF production in Escherichia coli
N. Nikolic, M. Sauert, T.G. Albanese, I. Moll, BMC Research Notes 15 (2022).
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| PubMed | Europe PMC
N. Nikolic, M. Sauert, T.G. Albanese, I. Moll, BMC Research Notes 15 (2022).
2022 | Journal Article | IST-REx-ID: 10812
The physiology and genetics of bacterial responses to antibiotic combinations
R. Römhild, M.T. Bollenbach, D.I. Andersson, Nature Reviews Microbiology 20 (2022) 478–490.
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| PubMed | Europe PMC
R. Römhild, M.T. Bollenbach, D.I. Andersson, Nature Reviews Microbiology 20 (2022) 478–490.
2022 | Journal Article | IST-REx-ID: 11843 |
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, ELife 11 (2022).
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K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, ELife 11 (2022).
2022 | Journal Article | IST-REx-ID: 12333 |
Adaptation dynamics between copynumber and point mutations
Tomanek, Isabella, Adaptation dynamics between copynumber and point mutations. eLife 11. 2022
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Tomanek, Isabella, Adaptation dynamics between copynumber and point mutations. eLife 11. 2022
2022 | Research Data Reference | IST-REx-ID: 12339 |
Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose
Tomanek, Isabella, Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose. 2022
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Tomanek, Isabella, Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose. 2022
2022 | Preprint | IST-REx-ID: 12478 |
Monitoring lineages of growing and dividing bacteria reveals an inducible memory of mar operon expression
C.C. Guet, L. Bruneaux, P. Oikonomou, M. Aldana, P. Cluzel, BioRxiv (n.d.).
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| Download Preprint (ext.)
C.C. Guet, L. Bruneaux, P. Oikonomou, M. Aldana, P. Cluzel, BioRxiv (n.d.).
2021 | Journal Article | IST-REx-ID: 9046 |
Mechanisms and therapeutic potential of collateral sensitivity to antibiotics
R. Römhild, D.I. Andersson, PLoS Pathogens 17 (2021).
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| DOI
| PubMed | Europe PMC
R. Römhild, D.I. Andersson, PLoS Pathogens 17 (2021).
2021 | Journal Article | IST-REx-ID: 9283 |
Local genetic context shapes the function of a gene regulatory network
A.A. Nagy-Staron, K. Tomasek, C. Caruso Carter, E. Sonnleitner, B. Kavcic, T. Paixão, C.C. Guet, ELife 10 (2021).
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| DOI
A.A. Nagy-Staron, K. Tomasek, C. Caruso Carter, E. Sonnleitner, B. Kavcic, T. Paixão, C.C. Guet, ELife 10 (2021).
2021 | Journal Article | IST-REx-ID: 9746 |
High potency of sequential therapy with only beta-lactam antibiotics
A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, H. Schulenburg, ELife 10 (2021).
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| Download Published Version (ext.)
| PubMed | Europe PMC
A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, H. Schulenburg, ELife 10 (2021).
2021 | Journal Article | IST-REx-ID: 9647 |
Long lived transients in gene regulation
T. Petrov, C. Igler, A. Sezgin, T.A. Henzinger, C.C. Guet, Theoretical Computer Science 893 (2021) 1–16.
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T. Petrov, C. Igler, A. Sezgin, T.A. Henzinger, C.C. Guet, Theoretical Computer Science 893 (2021) 1–16.
2021 | Journal Article | IST-REx-ID: 10363 |
Rational engineering of an erythropoietin fusion protein to treat hypoxia
J. Lee, A. Vernet, N. Gruber, K.M. Kready, D.R. Burrill, J.C. Way, P.A. Silver, Protein Engineering, Design and Selection 34 (2021).
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| Download Published Version (ext.)
| PubMed | Europe PMC
J. Lee, A. Vernet, N. Gruber, K.M. Kready, D.R. Burrill, J.C. Way, P.A. Silver, Protein Engineering, Design and Selection 34 (2021).
2021 | Journal Article | IST-REx-ID: 9822 |
Sequential and switchable patterning for studying cellular processes under spatiotemporal control
T. Zisis, J. Schwarz, M. Balles, M. Kretschmer, M. Nemethova, R.P. Chait, R. Hauschild, J. Lange, C.C. Guet, M.K. Sixt, S. Zahler, ACS Applied Materials and Interfaces 13 (2021) 35545–35560.
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| PubMed | Europe PMC
T. Zisis, J. Schwarz, M. Balles, M. Kretschmer, M. Nemethova, R.P. Chait, R. Hauschild, J. Lange, C.C. Guet, M.K. Sixt, S. Zahler, ACS Applied Materials and Interfaces 13 (2021) 35545–35560.
2021 | Thesis | IST-REx-ID: 10307 |
Pathogenic Escherichia coli hijack the host immune response
K. Tomasek, Pathogenic Escherichia Coli Hijack the Host Immune Response, IST Austria, 2021.
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K. Tomasek, Pathogenic Escherichia Coli Hijack the Host Immune Response, IST Austria, 2021.
2021 | Preprint | IST-REx-ID: 10316 |
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, BioRxiv (n.d.).
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| Files available
| DOI
| Download Preprint (ext.)
K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, BioRxiv (n.d.).
2020 | Thesis | IST-REx-ID: 8155 |
Gene regulation across scales – how biophysical constraints shape evolution
R. Grah, Gene Regulation across Scales – How Biophysical Constraints Shape Evolution, IST Austria, 2020.
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R. Grah, Gene Regulation across Scales – How Biophysical Constraints Shape Evolution, IST Austria, 2020.
2020 | Book Chapter | IST-REx-ID: 8173
Design and application of light-regulated receptor tyrosine kinases
S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
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| DOI
S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
2020 | Research Data | IST-REx-ID: 7383 |
Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation
R. Grah, (2020).
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| DOI
R. Grah, (2020).
2020 | Journal Article | IST-REx-ID: 7569 |
The relation between crosstalk and gene regulation form revisited
R. Grah, T. Friedlander, PLOS Computational Biology 16 (2020).
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R. Grah, T. Friedlander, PLOS Computational Biology 16 (2020).
2020 | Preprint | IST-REx-ID: 7675 |
Normative models of enhancer function
R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
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R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
2020 | Research Data | IST-REx-ID: 8951 |
Sequences of gene regulatory network permutations for the article "Local genetic context shapes the function of a gene regulatory network"
A.A. Nagy-Staron, (2020).
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| Files available
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A.A. Nagy-Staron, (2020).
2020 | Thesis | IST-REx-ID: 7680 |
Synthetic tools for optogenetic and chemogenetic inhibition of cellular signals
S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition of Cellular Signals, IST Austria, 2020.
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S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition of Cellular Signals, IST Austria, 2020.
2020 | Journal Article | IST-REx-ID: 7652 |
Gene amplification as a form of population-level gene expression regulation
I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik, C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
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I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik, C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
2020 | Thesis | IST-REx-ID: 8653 |
The evolution of gene expression by copy number and point mutations
I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations, IST Austria, 2020.
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I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations, IST Austria, 2020.
2019 | Research Data | IST-REx-ID: 7016 |
Data for the paper "Gene amplification as a form of population-level gene expression regulation"
I. Tomanek, (2019).
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I. Tomanek, (2019).
2019 | Conference Paper | IST-REx-ID: 7147
Transient memory in gene regulation
C.C. Guet, T.A. Henzinger, C. Igler, T. Petrov, A. Sezgin, in:, 17th International Conference on Computational Methods in Systems Biology, Springer Nature, 2019, pp. 155–187.
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C.C. Guet, T.A. Henzinger, C. Igler, T. Petrov, A. Sezgin, in:, 17th International Conference on Computational Methods in Systems Biology, Springer Nature, 2019, pp. 155–187.
2019 | Journal Article | IST-REx-ID: 6717 |
Commentary: A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision
C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019).
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C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019).
2019 | Journal Article | IST-REx-ID: 6784 |
Molecular noise of innate immunity shapes bacteria-phage ecologies
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, PLoS Computational Biology 15 (2019).
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| DOI
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, PLoS Computational Biology 15 (2019).
2019 | Journal Article | IST-REx-ID: 138 |
Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system
N. Nikolic, Current Genetics 65 (2019) 133–138.
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| DOI
N. Nikolic, Current Genetics 65 (2019) 133–138.
2019 | Research Data Reference | IST-REx-ID: 9786
Supporting text and results
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, (2019).
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| DOI
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, (2019).
2019 | Journal Article | IST-REx-ID: 196 |
Harmonic dynamics of the Abelian sandpile
M. Lang, M. Shkolnikov, Proceedings of the National Academy of Sciences 116 (2019) 2821–2830.
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| arXiv
M. Lang, M. Shkolnikov, Proceedings of the National Academy of Sciences 116 (2019) 2821–2830.
2019 | Journal Article | IST-REx-ID: 6465 |
A modular degron library for synthetic circuits in mammalian cells
H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, M. Fussenegger, Nature Communications 10 (2019).
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H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, M. Fussenegger, Nature Communications 10 (2019).
2019 | Thesis | IST-REx-ID: 6371 |
On the nature of gene regulatory design - The biophysics of transcription factor binding shapes gene regulation
C. Igler, On the Nature of Gene Regulatory Design - The Biophysics of Transcription Factor Binding Shapes Gene Regulation, IST Austria, 2019.
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C. Igler, On the Nature of Gene Regulatory Design - The Biophysics of Transcription Factor Binding Shapes Gene Regulation, IST Austria, 2019.
2018 | Journal Article | IST-REx-ID: 305
Fabrication and operation of microfluidic hanging drop networks
P. Misun, A. Birchler, M. Lang, A. Hierlemann, O. Frey, Methods in Molecular Biology 1771 (2018) 183–202.
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P. Misun, A. Birchler, M. Lang, A. Hierlemann, O. Frey, Methods in Molecular Biology 1771 (2018) 183–202.
2018 | Journal Article | IST-REx-ID: 82 |
Leaky resistance and the conditions for the existence of lytic bacteriophage
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, PLoS Biology 16 (2018).
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| DOI
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, PLoS Biology 16 (2018).
2018 | Journal Article | IST-REx-ID: 457
Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity
M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.
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| DOI
M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.
2018 | Journal Article | IST-REx-ID: 503
Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains
K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.
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K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.
2018 | Research Data | IST-REx-ID: 5569 |
Time-lapse microscopy data
T. Bergmiller, N. Nikolic, (2018).
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| Files available
| DOI
T. Bergmiller, N. Nikolic, (2018).
2018 | Journal Article | IST-REx-ID: 5984 |
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
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| Files available
| DOI
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
2018 | Journal Article | IST-REx-ID: 723 |
How to escape local optima in black box optimisation when non elitism outperforms elitism
P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 80 (2018) 1604–1633.
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P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 80 (2018) 1604–1633.
2018 | Journal Article | IST-REx-ID: 161 |
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
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| DOI
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
2018 | Journal Article | IST-REx-ID: 19 |
Nonoptimal gene expression creates latent potential for antibiotic resistance
A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018) 2669–2684.
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| Download Submitted Version (ext.)
| PubMed | Europe PMC
A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018) 2669–2684.
2018 | Research Data Reference | IST-REx-ID: 9810
Numerical data used in figures
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, (2018).
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| Files available
| DOI
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, (2018).
2018 | Journal Article | IST-REx-ID: 438 |
Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations
N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.
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| DOI
N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.
2018 | Journal Article | IST-REx-ID: 67 |
Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.
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| Files available
| DOI
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.
2018 | Research Data | IST-REx-ID: 5585 |
Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, (2018).
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| Files available
| DOI
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, (2018).
2018 | Thesis | IST-REx-ID: 26 |
The influence of sequence context on the evolution of bacterial gene expression
M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, IST Austria, 2018.
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| DOI
M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, IST Austria, 2018.
2017 | Journal Article | IST-REx-ID: 538 |
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
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| DOI
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
2017 | Journal Article | IST-REx-ID: 541 |
Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, PLoS Genetics 13 (2017).
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| Files available
| DOI
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, PLoS Genetics 13 (2017).
2017 | Research Data | IST-REx-ID: 5560 |
Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, (2017).
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| Files available
| DOI
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, (2017).
2017 | Research Data | IST-REx-ID: 5564 |
Fastq files for "Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection"
M. Steinrück, C.C. Guet, (2017).
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| Files available
| DOI
M. Steinrück, C.C. Guet, (2017).
2017 | Journal Article | IST-REx-ID: 570 |
Regulatory network structure determines patterns of intermolecular epistasis
M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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| Files available
| DOI
M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 1084
Insulation and wiring specificity of BceR like response regulators and their target promoters in Bacillus subtilis
C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T. Mascher, Molecular Microbiology 104 (2017) 16–31.
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C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T. Mascher, Molecular Microbiology 104 (2017) 16–31.
2017 | Journal Article | IST-REx-ID: 613 |
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
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| Files available
| DOI
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
2017 | Journal Article | IST-REx-ID: 624 |
MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations
N. Nikolic, Z. Didara, I. Moll, PeerJ 2017 (2017).
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| Files available
| DOI
N. Nikolic, Z. Didara, I. Moll, PeerJ 2017 (2017).
2017 | Journal Article | IST-REx-ID: 655 |
Bacterial flagella grow through an injection diffusion mechanism
T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
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| Files available
| DOI
T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Science 356 (2017) 311–315.
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| Files available
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T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Science 356 (2017) 311–315.
2017 | Journal Article | IST-REx-ID: 1336 |
Towards a runtime comparison of natural and artificial evolution
T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017) 681–713.
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| Files available
| DOI
T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017) 681–713.
2017 | Journal Article | IST-REx-ID: 1351 |
Model checking the evolution of gene regulatory networks
M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, Acta Informatica 54 (2017) 765–787.
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| Files available
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M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, Acta Informatica 54 (2017) 765–787.
2017 | Journal Article | IST-REx-ID: 1007 |
Zeros of nonlinear systems with input invariances
M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
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| Files available
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M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
2017 | Journal Article | IST-REx-ID: 954 |
On the mechanistic nature of epistasis in a canonical cis-regulatory element
M. Lagator, T. Paixao, N.H. Barton, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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| Files available
| DOI
M. Lagator, T. Paixao, N.H. Barton, J.P. Bollback, C.C. Guet, ELife 6 (2017).
2017 | Research Data Reference | IST-REx-ID: 9844
Source data for figures and tables
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
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N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
2017 | Research Data Reference | IST-REx-ID: 9845
Mathematical model
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
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N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
2017 | Research Data Reference | IST-REx-ID: 9846
Supplementary methods
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
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N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, (2017).
2017 | Research Data Reference | IST-REx-ID: 9849
Modelling and simulation details
M. Lukacisinova, S. Novak, T. Paixao, (2017).
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M. Lukacisinova, S. Novak, T. Paixao, (2017).
2017 | Research Data Reference | IST-REx-ID: 9850
Extensions of the model
M. Lukacisinova, S. Novak, T. Paixao, (2017).
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M. Lukacisinova, S. Novak, T. Paixao, (2017).
2017 | Research Data Reference | IST-REx-ID: 9851
Heuristic prediction for multiple stresses
M. Lukacisinova, S. Novak, T. Paixao, (2017).
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M. Lukacisinova, S. Novak, T. Paixao, (2017).
2017 | Research Data Reference | IST-REx-ID: 9852
Resistance frequencies for different combination strategies
M. Lukacisinova, S. Novak, T. Paixao, (2017).
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M. Lukacisinova, S. Novak, T. Paixao, (2017).
2017 | Thesis | IST-REx-ID: 202 |
Biology of restriction-modification systems at the single-cell and population level
M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell and Population Level, IST Austria, 2017.
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M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell and Population Level, IST Austria, 2017.
2017 | Journal Article | IST-REx-ID: 561 |
Effects of mutations in phage restriction sites during escape from restriction–modification
M. Pleska, C.C. Guet, Biology Letters 13 (2017).
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M. Pleska, C.C. Guet, Biology Letters 13 (2017).
2017 | Research Data Reference | IST-REx-ID: 9847 |
Supplementary materials and methods; Full data set from effects of mutations in phage restriction sites during escape from restriction–modification
M. Pleska, C.C. Guet, (2017).
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M. Pleska, C.C. Guet, (2017).
2017 | Journal Article | IST-REx-ID: 735
An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate
V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
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V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
2017 | Journal Article | IST-REx-ID: 1028 |
Green-light-induced inactivation of receptor signaling using cobalamin-binding domains
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
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S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
2017 | Journal Article | IST-REx-ID: 704 |
Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection
M. Steinrück, C.C. Guet, ELife 6 (2017).
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M. Steinrück, C.C. Guet, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 696 |
Stress induced mutagenesis: Stress diversity facilitates the persistence of mutator genes
M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
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M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
2016 | Conference Paper | IST-REx-ID: 1093 |
Linear distances between Markov chains
P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
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P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
2016 | Journal Article | IST-REx-ID: 1170
Modular parameter identification of biomolecular networks
M. Lang, J. Stelling, SIAM Journal on Scientific Computing 38 (2016) B988–B1008.
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M. Lang, J. Stelling, SIAM Journal on Scientific Computing 38 (2016) B988–B1008.
2016 | Conference Paper | IST-REx-ID: 1220 |
Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency
G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.
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G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.
2016 | Conference Paper | IST-REx-ID: 1234 |
Faster statistical model checking for unbounded temporal properties
P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Springer, 2016, pp. 112–129.
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P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Springer, 2016, pp. 112–129.
2016 | Journal Article | IST-REx-ID: 1243
Bacterial autoimmunity due to a restriction-modification system
M. Pleska, L. Qian, R. Okura, T. Bergmiller, Y. Wakamoto, E. Kussell, C.C. Guet, Current Biology 26 (2016) 404–409.
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M. Pleska, L. Qian, R. Okura, T. Bergmiller, Y. Wakamoto, E. Kussell, C.C. Guet, Current Biology 26 (2016) 404–409.
2016 | Journal Article | IST-REx-ID: 1250 |
Genetic manipulation of glycogen allocation affects replicative lifespan in E coli
A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, M. Ackermann, PLoS Genetics 12 (2016).
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A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, M. Ackermann, PLoS Genetics 12 (2016).
2016 | Journal Article | IST-REx-ID: 1290 |
Compounds that select against the tetracycline-resistance efflux pump
L. Stone, M. Baym, T. Lieberman, R.P. Chait, J. Clardy, R. Kishony, Nature Chemical Biology 12 (2016) 902–904.
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L. Stone, M. Baym, T. Lieberman, R.P. Chait, J. Clardy, R. Kishony, Nature Chemical Biology 12 (2016) 902–904.
2016 | Conference Paper | IST-REx-ID: 1320
Scale-invariant systems realize nonlinear differential operators
M. Lang, E. Sontag, in:, IEEE, 2016.
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M. Lang, E. Sontag, in:, IEEE, 2016.
2016 | Journal Article | IST-REx-ID: 1332 |
Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments
R.P. Chait, A. Palmer, I. Yelin, R. Kishony, Nature Communications 7 (2016).
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R.P. Chait, A. Palmer, I. Yelin, R. Kishony, Nature Communications 7 (2016).
2016 | Journal Article | IST-REx-ID: 1342 |
Spatiotemporal microbial evolution on antibiotic landscapes
M. Baym, T. Lieberman, E. Kelsic, R.P. Chait, R. Gross, I. Yelin, R. Kishony, Science 353 (2016) 1147–1151.
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M. Baym, T. Lieberman, E. Kelsic, R.P. Chait, R. Gross, I. Yelin, R. Kishony, Science 353 (2016) 1147–1151.
2016 | Conference Paper | IST-REx-ID: 1349 |
When non-elitism outperforms elitism for crossing fitness valleys
P. Oliveto, T. Paixao, J. Heredia, D. Sudholt, B. Trubenova, in:, Proceedings of the Genetic and Evolutionary Computation Conference 2016 , ACM, 2016, pp. 1163–1170.
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P. Oliveto, T. Paixao, J. Heredia, D. Sudholt, B. Trubenova, in:, Proceedings of the Genetic and Evolutionary Computation Conference 2016 , ACM, 2016, pp. 1163–1170.
2016 | Journal Article | IST-REx-ID: 1358 |
Intrinsic limits to gene regulation by global crosstalk
T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkačik, Nature Communications 7 (2016).
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T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkačik, Nature Communications 7 (2016).
2016 | Journal Article | IST-REx-ID: 1359 |
The effect of gene interactions on the long-term response to selection
T. Paixao, N.H. Barton, PNAS 113 (2016) 4422–4427.
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T. Paixao, N.H. Barton, PNAS 113 (2016) 4422–4427.
2016 | Journal Article | IST-REx-ID: 1427 |
Epistatic interactions in the arabinose cis-regulatory element
M. Lagator, C. Igler, A. Moreno, C.C. Guet, J.P. Bollback, Molecular Biology and Evolution 33 (2016) 761–769.
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M. Lagator, C. Igler, A. Moreno, C.C. Guet, J.P. Bollback, Molecular Biology and Evolution 33 (2016) 761–769.
2016 | Conference Paper | IST-REx-ID: 1524 |
Efficient reduction of kappa models by static inspection of the rule-set
A. Beica, C.C. Guet, T. Petrov, in:, Springer, 2016, pp. 173–191.
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A. Beica, C.C. Guet, T. Petrov, in:, Springer, 2016, pp. 173–191.
2016 | Journal Article | IST-REx-ID: 1008
An orthogonal permease–inducer–repressor feedback loop shows bistability
R. Gnügge, L. Dharmarajan, M. Lang, J. Stelling, ACS Synthetic Biology 5 (2016) 1098–1107.
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R. Gnügge, L. Dharmarajan, M. Lang, J. Stelling, ACS Synthetic Biology 5 (2016) 1098–1107.
2016 | Research Data Reference | IST-REx-ID: 9873
Quantification of the growth rate reduction as a consequence of age-specific mortality
A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, M. Ackermann, (2016).
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A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, M. Ackermann, (2016).
2016 | Journal Article | IST-REx-ID: 5749 |
Adaptation to parasites and costs of parasite resistance in mutator and nonmutator bacteria
S. Wielgoss, T. Bergmiller, A.M. Bischofberger, A.R. Hall, Molecular Biology and Evolution 33 (2016) 770–782.
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| PubMed | Europe PMC
S. Wielgoss, T. Bergmiller, A.M. Bischofberger, A.R. Hall, Molecular Biology and Evolution 33 (2016) 770–782.
2015 | Journal Article | IST-REx-ID: 1542 |
Toward a unifying framework for evolutionary processes
T. Paixao, G. Badkobeh, N.H. Barton, D. Çörüş, D. Dang, T. Friedrich, P. Lehre, D. Sudholt, A. Sutton, B. Trubenova, Journal of Theoretical Biology 383 (2015) 28–43.
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T. Paixao, G. Badkobeh, N.H. Barton, D. Çörüş, D. Dang, T. Friedrich, P. Lehre, D. Sudholt, A. Sutton, B. Trubenova, Journal of Theoretical Biology 383 (2015) 28–43.
2015 | Journal Article | IST-REx-ID: 1666 |
Dynamics of transcription factor binding site evolution
M. Tugrul, T. Paixao, N.H. Barton, G. Tkačik, PLoS Genetics 11 (2015).
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M. Tugrul, T. Paixao, N.H. Barton, G. Tkačik, PLoS Genetics 11 (2015).
2015 | Conference Paper | IST-REx-ID: 1835 |
Model checking gene regulatory networks
M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, 9035 (2015) 469–483.
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M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, 9035 (2015) 469–483.
2015 | Journal Article | IST-REx-ID: 1840 |
Optimal Kullback-Leibler aggregation via information bottleneck
B. Geiger, T. Petrov, G. Kubin, H. Koeppl, IEEE Transactions on Automatic Control 60 (2015) 1010–1022.
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B. Geiger, T. Petrov, G. Kubin, H. Koeppl, IEEE Transactions on Automatic Control 60 (2015) 1010–1022.
2015 | Conference Paper | IST-REx-ID: 1430 |
First steps towards a runtime comparison of natural and artificial evolution
T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp. 1455–1462.
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T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp. 1455–1462.