--- OA_place: publisher _id: '22255' abstract: - lang: eng text: "This thesis studies spectral rigidity and nonrigidity phenomena in dynamical systems. The central question is whether a dynamical system can be determined, up to a natural conjugacy, from its spectrum. We consider three related spectra: the length spectrum, the action spectrum, and the Lyapunov spectrum.\r\n\r\nThe first part of the thesis concerns Liouville metrics on the two-dimensional torus. It is a long-standing folklore conjecture that Liouville metrics are the only integrable metrics on the torus. We prove a length-spectral rigidity result for linear conformal deformations of Liouville metrics by exploiting the dynamical properties of the rational tori -- analogues of the resonant convex caustics in billiards. We also establish a complementary classification result showing that marked-length-isospectral Liouville metrics are characterized by rearrangements of the one-dimensional functions appearing in their conformal factors, generalizing a theorem of Abbondandolo-Mazzucchelli. In particular, the second result gives nonrigidity examples within the class of Liouville metrics.\r\n\r\nThe second part of the thesis studies the standard map from the viewpoint of action and Lyapunov spectra. We construct nontrivial deformations of the standard map which preserve the symplectic actions (respectively, the Lyapunov exponents) of infinitely many periodic orbits accumulating on an invariant curve. The proof combines a resonant normal form construction with Picard iteration schemes to obtain a sequence of periodic orbits accumulating on an invariant curve with a Liouville rotation number. Within the resonant normal forms we capture the dependence of these periodic orbits on the resonant Fourier coefficients of the dynamics on the invariant curve and, using the contraction mapping principle, obtain a suitable deformation achieving the prescribed spectral data associated with this sequence of orbits. The result can be viewed as a symplectic twist-map analogue of a length-spectral nonrigidity phenomenon for Riemannian manifolds and convex billiards, and it motivates the existence problem for similar 'partially length-isospectral' deformations of strictly convex billiard tables.\r\n" acknowledged_ssus: - _id: E-Lib - _id: CampIT acknowledgement: "The financial support of the ERC grant SPERIG #885707 is gratefully acknowledged.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Yunzhe full_name: Li, Yunzhe id: 41cb05d3-f128-11eb-9611-e4e2b3cfba31 last_name: Li citation: ama: Li Y. Spectral rigidity and nonrigidity of dynamical systems. 2026. doi:10.15479/AT-ISTA-22255 apa: Li, Y. (2026). Spectral rigidity and nonrigidity of dynamical systems. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22255 chicago: Li, Yunzhe. “Spectral Rigidity and Nonrigidity of Dynamical Systems.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22255. ieee: Y. Li, “Spectral rigidity and nonrigidity of dynamical systems,” Institute of Science and Technology Austria, 2026. ista: Li Y. 2026. Spectral rigidity and nonrigidity of dynamical systems. Institute of Science and Technology Austria. mla: Li, Yunzhe. Spectral Rigidity and Nonrigidity of Dynamical Systems. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22255. short: Y. Li, Spectral Rigidity and Nonrigidity of Dynamical Systems, Institute of Science and Technology Austria, 2026. corr_author: '1' date_created: 2026-07-08T12:44:31Z date_published: 2026-07-11T00:00:00Z date_updated: 2026-07-20T14:58:23Z day: '11' ddc: - '515' degree_awarded: PhD department: - _id: GradSch - _id: VaKa doi: 10.15479/AT-ISTA-22255 doi_confirm: '1' ec_funded: 1 file: - access_level: open_access checksum: 8201cb5a427656a41828ecde8a85c04b content_type: application/pdf creator: yli date_created: 2026-07-14T10:48:45Z date_updated: 2026-07-14T10:48:45Z file_id: '22337' file_name: 2026_Li_Yunzhe_Thesis.pdf file_size: 1260717 relation: main_file - access_level: closed checksum: 19ee8461ed77f5b7980fc9461f778b6f content_type: application/x-zip-compressed creator: yli date_created: 2026-07-14T11:07:18Z date_updated: 2026-07-20T14:00:33Z file_id: '22339' file_name: 2026_Li_Yunzhe_Thesis.zip file_size: 418752 relation: source_file file_date_updated: 2026-07-20T14:00:33Z has_accepted_license: '1' language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: '131' project: - _id: 9B8B92DE-BA93-11EA-9121-9846C619BF3A call_identifier: H2020 grant_number: '885707' name: Spectral rigidity and integrability for billiards and geodesic flows publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '22340' relation: part_of_dissertation status: public - id: '22341' relation: part_of_dissertation status: public status: public supervisor: - first_name: Vadim full_name: Kaloshin, Vadim id: FE553552-CDE8-11E9-B324-C0EBE5697425 last_name: Kaloshin orcid: 0000-0002-6051-2628 title: Spectral rigidity and nonrigidity of dynamical systems tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- OA_place: repository OA_type: gold _id: '18697' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules but dense, synapse-level circuit reconstruction by light microscopy has been out of reach due to limitations in resolution, contrast, and volumetric imaging capability. Here we developed light-microscopy based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning based segmentation and analysis of connectivity, thus directly incorporating molecular information in synapse-level brain tissue reconstructions. LICONN will allow synapse-level brain tissue phenotyping in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: E-Lib article_processing_charge: No author: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger citation: ama: Danzl JG, Lyudchik J, Kreuzinger C. Light-microscopy based connectomic reconstruction of mammalian brain tissue. 2025. doi:10.15479/AT:ISTA:18697 apa: Danzl, J. G., Lyudchik, J., & Kreuzinger, C. (2025). Light-microscopy based connectomic reconstruction of mammalian brain tissue. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:18697 chicago: Danzl, Johann G, Julia Lyudchik, and Caroline Kreuzinger. “Light-Microscopy Based Connectomic Reconstruction of Mammalian Brain Tissue.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT:ISTA:18697. ieee: J. G. Danzl, J. Lyudchik, and C. Kreuzinger, “Light-microscopy based connectomic reconstruction of mammalian brain tissue.” Institute of Science and Technology Austria, 2025. ista: Danzl JG, Lyudchik J, Kreuzinger C. 2025. Light-microscopy based connectomic reconstruction of mammalian brain tissue, Institute of Science and Technology Austria, 10.15479/AT:ISTA:18697. mla: Danzl, Johann G., et al. Light-Microscopy Based Connectomic Reconstruction of Mammalian Brain Tissue. Institute of Science and Technology Austria, 2025, doi:10.15479/AT:ISTA:18697. short: J.G. Danzl, J. Lyudchik, C. Kreuzinger, (2025). contributor: - contributor_type: researcher first_name: Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - contributor_type: researcher first_name: Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - contributor_type: researcher first_name: Michal last_name: Januszewski - contributor_type: researcher first_name: Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - contributor_type: researcher first_name: Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - contributor_type: researcher first_name: Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer - contributor_type: researcher first_name: Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - contributor_type: researcher first_name: Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - contributor_type: researcher first_name: Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - contributor_type: researcher first_name: Alban last_name: Cenameri - contributor_type: researcher first_name: Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - contributor_type: researcher first_name: Viren last_name: Jain - contributor_type: researcher first_name: Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 corr_author: '1' date_created: 2024-12-20T09:22:20Z date_published: 2025-03-03T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '03' ddc: - '570' department: - _id: JoDa doi: 10.15479/AT:ISTA:18697 file: - access_level: open_access checksum: d2c3efcd354f967290f91ff34dfb3cc1 content_type: text/rtf creator: jdanzl date_created: 2025-02-28T16:50:39Z date_updated: 2025-02-28T16:50:39Z file_id: '19275' file_name: Readme_Data_Tavakoli_et_al_2025.rtf file_size: 1922 relation: main_file success: 1 - access_level: open_access checksum: b20cfb9b7030375f94d4b9bc5ce5cee9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19089' file_name: Fig1b (1).tif file_size: 69884200 relation: main_file success: 1 - access_level: open_access checksum: 2059d95e6f289cc10c970c30cd5c09a0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:36Z date_updated: 2025-02-27T08:16:36Z file_id: '19090' file_name: Fig1b (2).tif file_size: 4511994 relation: main_file success: 1 - access_level: open_access checksum: a259143bb581b998e9411f90403951a3 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:36Z date_updated: 2025-02-27T08:16:36Z file_id: '19091' file_name: Fig1b (3).tif file_size: 636956 relation: main_file success: 1 - access_level: open_access checksum: e4f07b9a7a40ceac70d1c02efdaac8c0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19092' file_name: Fig1b (4).tif file_size: 76830 relation: main_file success: 1 - access_level: open_access checksum: 99a9790285bea3ef600c1590e41c32ec content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19093' file_name: Fig1c (1).tif file_size: 226548 relation: main_file success: 1 - access_level: open_access checksum: 4e90c8724de5a3ae7537eb5bb2ef0480 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19094' file_name: Fig1c (2).tif file_size: 219676 relation: main_file success: 1 - access_level: open_access checksum: 218d009d9f15c77954ada71c507da531 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19095' file_name: Fig1c (3).tif file_size: 219676 relation: main_file success: 1 - access_level: open_access checksum: cb58d865959cbdffae61f47e1d41d53e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T08:16:37Z date_updated: 2025-02-27T08:16:37Z file_id: '19096' file_name: Fig1c (4).tif file_size: 3824598 relation: main_file success: 1 - access_level: open_access checksum: 0b8c790576fe30307050675103eafe93 content_type: text/rtf creator: ckreuzin date_created: 2025-02-27T12:26:54Z date_updated: 2025-02-27T12:26:54Z file_id: '19097' file_name: Fig 2a_b_c_d_e_f.rtf file_size: 1510 relation: main_file success: 1 - access_level: open_access checksum: c9c1a66ed113c4bb74c8b2f65c5edcbb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:25Z date_updated: 2025-02-27T12:27:25Z file_id: '19098' file_name: Fig3f.tif file_size: 83049 relation: main_file success: 1 - access_level: open_access checksum: 4a822dffdca45d97d4a9b5b89aaec0f9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:43Z date_updated: 2025-02-27T12:27:43Z file_id: '19099' file_name: Fig5l (1).tif file_size: 640644 relation: main_file success: 1 - access_level: open_access checksum: af130e9951a9716f40b11a5e67183fe7 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:43Z date_updated: 2025-02-27T12:27:43Z file_id: '19100' file_name: Fig5l (2).tif file_size: 640644 relation: main_file success: 1 - access_level: open_access checksum: cdc8829aa194593c9daf1cdaf79d9c9b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:55Z date_updated: 2025-02-27T12:27:55Z file_id: '19101' file_name: ExD2 (1).tif file_size: 503452 relation: main_file success: 1 - access_level: open_access checksum: 66808762dad2c15d0fce0dc892ce2cf0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:55Z date_updated: 2025-02-27T12:27:55Z file_id: '19102' file_name: ExD2 (2).tif file_size: 503452 relation: main_file success: 1 - access_level: open_access checksum: c7e29bf95022538a9e63149413ab2691 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:27:56Z date_updated: 2025-02-27T12:27:56Z file_id: '19103' file_name: ExD2 (3).tif file_size: 497260 relation: main_file success: 1 - access_level: open_access checksum: 7da1e01b4a5ec0c598b95bcf1b1746e1 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:58Z date_updated: 2025-02-27T12:28:58Z file_id: '19104' file_name: EXD2 overview.tif file_size: 2240788643 relation: main_file success: 1 - access_level: open_access checksum: b87093567e71c5e27007bde717017f02 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:06Z date_updated: 2025-02-27T12:28:06Z file_id: '19105' file_name: ExD3_a (1).tif file_size: 635780 relation: main_file success: 1 - access_level: open_access checksum: ccbfca6f0943887c202d635e1988e15c content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:06Z date_updated: 2025-02-27T12:28:06Z file_id: '19106' file_name: ExD3_a (2).tif file_size: 635780 relation: main_file success: 1 - access_level: open_access checksum: a601cd6153f3dd3900496bd3715780dc content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:06Z date_updated: 2025-02-27T12:28:06Z file_id: '19107' file_name: ExD3_a overview.tif file_size: 8850309 relation: main_file success: 1 - access_level: open_access checksum: 82fe82494388f2b514e5eab08cf42567 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:06Z date_updated: 2025-02-27T12:28:06Z file_id: '19108' file_name: ExD3_b (1).tif file_size: 888645 relation: main_file success: 1 - access_level: open_access checksum: 6f0b4bc3cc46f9f139776b5baf608d40 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:06Z date_updated: 2025-02-27T12:28:06Z file_id: '19109' file_name: ExD3_b (2).tif file_size: 888645 relation: main_file success: 1 - access_level: open_access checksum: f6d984add5f2bdf4bf0c5a8d52c3dbdd content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:08Z date_updated: 2025-02-27T12:28:08Z file_id: '19110' file_name: ExD3_b overview.tif file_size: 25170991 relation: main_file success: 1 - access_level: open_access checksum: c508a203601d322039716d74799df4fd content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:16Z date_updated: 2025-02-27T12:28:16Z file_id: '19111' file_name: ExD5_a (1).tif file_size: 748126 relation: main_file success: 1 - access_level: open_access checksum: 195a02aa816058454d6fb9347834aef8 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:17Z date_updated: 2025-02-27T12:28:17Z file_id: '19112' file_name: ExD5_a (2).tif file_size: 167518 relation: main_file success: 1 - access_level: open_access checksum: 1eb28e43902974d7f424e803e99c0234 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:17Z date_updated: 2025-02-27T12:28:17Z file_id: '19113' file_name: ExD5_a (3).tif file_size: 167518 relation: main_file success: 1 - access_level: open_access checksum: e450c88cac136a11af8c52e4966dcb15 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:18Z date_updated: 2025-02-27T12:28:18Z file_id: '19114' file_name: ExD5_a (4).tif file_size: 25169039 relation: main_file success: 1 - access_level: open_access checksum: 839a53eb45926407639ccdf07a326f73 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:18Z date_updated: 2025-02-27T12:28:18Z file_id: '19115' file_name: ExD5_a (5).tif file_size: 748126 relation: main_file success: 1 - access_level: open_access checksum: 080703b3ee6001af8805d079f0ef101d content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:18Z date_updated: 2025-02-27T12:28:18Z file_id: '19116' file_name: ExD5_b (1).tif file_size: 5959861 relation: main_file success: 1 - access_level: open_access checksum: a51cca7fd7283491f09ead98bac06be8 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:30:13Z date_updated: 2025-02-27T12:30:13Z file_id: '19128' file_name: ExD5_b (2).tif file_size: 603445 relation: main_file success: 1 - access_level: open_access checksum: 417d4c6c4cbf4580d1b0f252ad0d1b53 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:19Z date_updated: 2025-02-27T12:28:19Z file_id: '19117' file_name: ExD5_b (3).tif file_size: 603445 relation: main_file success: 1 - access_level: open_access checksum: a7cfb8c48d9696f7be2068d7e5b97ec0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:19Z date_updated: 2025-02-27T12:28:19Z file_id: '19118' file_name: ExD5_c (1).tif file_size: 480392 relation: main_file success: 1 - access_level: open_access checksum: 4e61066979d7002bd1d5e295a0031fa6 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:20Z date_updated: 2025-02-27T12:28:20Z file_id: '19119' file_name: ExD5_c (2).tif file_size: 5947784 relation: main_file success: 1 - access_level: open_access checksum: 2c1e59c738e9ca2cf6d474a522746bd0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:20Z date_updated: 2025-02-27T12:28:20Z file_id: '19120' file_name: ExD5_c (3).tif file_size: 480392 relation: main_file success: 1 - access_level: open_access checksum: 86ff0d32c6004ba817c0fb8581853f70 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:34Z date_updated: 2025-02-27T12:28:34Z file_id: '19121' file_name: ExD6_C (1).tif file_size: 25170872 relation: main_file success: 1 - access_level: open_access checksum: ba8c3fd2cb84bea6d0ff4b7346a1f617 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:34Z date_updated: 2025-02-27T12:28:34Z file_id: '19122' file_name: ExD6_C (2).tif file_size: 595434 relation: main_file success: 1 - access_level: open_access checksum: 6c235a6fc961ca5fec8e6ad90cca585b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:34Z date_updated: 2025-02-27T12:28:34Z file_id: '19123' file_name: ExD6_C (3).tif file_size: 595434 relation: main_file success: 1 - access_level: open_access checksum: aae7959ad3571773a60c93d8fb239f0e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:34Z date_updated: 2025-02-27T12:28:34Z file_id: '19124' file_name: ExD6_HT (1).tif file_size: 12589048 relation: main_file success: 1 - access_level: open_access checksum: 91d134716e3162c7a1a399729ed43b84 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:35Z date_updated: 2025-02-27T12:28:35Z file_id: '19125' file_name: ExD6_HT (2).tif file_size: 12589516 relation: main_file success: 1 - access_level: open_access checksum: 154e29281e9640da6a86d55a191a7684 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:36Z date_updated: 2025-02-27T12:28:36Z file_id: '19126' file_name: ExD6_PA (1).tif file_size: 12595178 relation: main_file success: 1 - access_level: open_access checksum: 86f22b9fd2e5b231451f6f98c9345acb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:28:36Z date_updated: 2025-02-27T12:28:36Z file_id: '19127' file_name: ExD6_PA (2).tif file_size: 12595070 relation: main_file success: 1 - access_level: open_access checksum: c5d8929322f3123dd03d77a51b9dc32d content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:30:55Z date_updated: 2025-02-27T12:30:55Z file_id: '19129' file_name: ExD7 (1).tif file_size: 210228181 relation: main_file success: 1 - access_level: open_access checksum: 12cfa75bba1c486f8127d28c114ec4bf content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:30:51Z date_updated: 2025-02-27T12:30:51Z file_id: '19130' file_name: ExD7 (2).tif file_size: 8439640 relation: main_file success: 1 - access_level: open_access checksum: 9b4b4fde987f0585ccb2ba43ccf64ae0 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:30:51Z date_updated: 2025-02-27T12:30:51Z file_id: '19131' file_name: ExD7 (3).tif file_size: 8439640 relation: main_file success: 1 - access_level: open_access checksum: 3430b0e859cb2840078e63acca6dc5a7 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:02Z date_updated: 2025-02-27T12:31:02Z file_id: '19132' file_name: ExD8 (1).tif file_size: 12583305 relation: main_file success: 1 - access_level: open_access checksum: 8eb083751ef494d0a982110702a4e076 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:02Z date_updated: 2025-02-27T12:31:02Z file_id: '19133' file_name: ExD8 (2).tif file_size: 12583304 relation: main_file success: 1 - access_level: open_access checksum: 9a016467f871c78cefc7c13cd71b8a23 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19134' file_name: ExD8 (3).tif file_size: 12583296 relation: main_file success: 1 - access_level: open_access checksum: 719785390d3e417325673f218a03c2ae content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19135' file_name: ExD8 (4).tif file_size: 12583307 relation: main_file success: 1 - access_level: open_access checksum: 65a0aee4b5c8cd3f76189e4397bd6544 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19136' file_name: ExD8 (5).tif file_size: 12583307 relation: main_file success: 1 - access_level: open_access checksum: 667753716b7148878a0b512ddc2074b4 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19137' file_name: ExD8 (6).tif file_size: 12583286 relation: main_file success: 1 - access_level: open_access checksum: 61eb5fc89cbacc3bb027919139b3a4ab content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19138' file_name: ExD8 (7).tif file_size: 12583305 relation: main_file success: 1 - access_level: open_access checksum: eed374ceb917f66b0e9cf4ee3aed0eba content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:03Z date_updated: 2025-02-27T12:31:03Z file_id: '19139' file_name: ExD8 (8).tif file_size: 12583264 relation: main_file success: 1 - access_level: open_access checksum: 51d3c92bffe30a6ee417a42d24c42449 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:04Z date_updated: 2025-02-27T12:31:04Z file_id: '19140' file_name: ExD8 (9).tif file_size: 12583305 relation: main_file success: 1 - access_level: open_access checksum: a451c488fca7772e55d534e65f739a5d content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:32:26Z date_updated: 2025-02-27T12:32:26Z file_id: '19141' file_name: ExD9_a.tif file_size: 2637707980 relation: main_file success: 1 - access_level: open_access checksum: 2b671ae3857517cc2493d95435eb5017 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:12Z date_updated: 2025-02-27T12:31:12Z file_id: '19142' file_name: ExD9_b (1).tif file_size: 5931874 relation: main_file success: 1 - access_level: open_access checksum: 5b0a6d2fbd3a4790e42d64ddf082ac44 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:31:13Z date_updated: 2025-02-27T12:31:13Z file_id: '19143' file_name: ExD9_b (2).png file_size: 5574502 relation: main_file success: 1 - access_level: open_access checksum: 93b1ca9fe6689f972466ca7021333a2b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:13Z date_updated: 2025-02-27T12:31:13Z file_id: '19144' file_name: ExD9_c (1).tif file_size: 936816 relation: main_file success: 1 - access_level: open_access checksum: 087a6e5cd69ed279f4135e5acbcf0243 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:14Z date_updated: 2025-02-27T12:31:14Z file_id: '19145' file_name: ExD9_c (2).tif file_size: 9971050 relation: main_file success: 1 - access_level: open_access checksum: 055512e172d8c0b3f552ecdcf62d8913 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:31:14Z date_updated: 2025-02-27T12:31:14Z file_id: '19146' file_name: ExD9_c (3).tif file_size: 12589300 relation: main_file success: 1 - access_level: open_access checksum: 0c49d7bae8d7ce058d9339d2acb5108a content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:35:44Z date_updated: 2025-02-27T12:35:44Z file_id: '19155' file_name: ExD10_a (1).tif file_size: 12587348 relation: main_file success: 1 - access_level: open_access checksum: 108d47b78fd5af3a751319b8a0f336c5 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:32:38Z date_updated: 2025-02-27T12:32:38Z file_id: '19147' file_name: ExD10_a (2).tif file_size: 12587344 relation: main_file success: 1 - access_level: open_access checksum: dab543a769dd05cfbd66c8bc5877decf content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:32:39Z date_updated: 2025-02-27T12:32:39Z file_id: '19148' file_name: ExD10_a (3).tif file_size: 622780 relation: main_file success: 1 - access_level: open_access checksum: 31feb7fcc156ba1f62c9c18c7adee1bd content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:32:39Z date_updated: 2025-02-27T12:32:39Z file_id: '19149' file_name: ExD10_a (4).tif file_size: 424064 relation: main_file success: 1 - access_level: open_access checksum: 069fa6237648dee9080bc779ae8bb7ab content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:32:39Z date_updated: 2025-02-27T12:32:39Z file_id: '19150' file_name: ExD10_c.png file_size: 695657 relation: main_file success: 1 - access_level: open_access checksum: 774a892849e024ee079e14d456908529 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:32:39Z date_updated: 2025-02-27T12:32:39Z file_id: '19151' file_name: ExD10_d (1).png file_size: 2510928 relation: main_file success: 1 - access_level: open_access checksum: 4f6f50fb534e7419189b82fc2b2359e8 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:32:39Z date_updated: 2025-02-27T12:32:39Z file_id: '19152' file_name: ExD10_d (2).png file_size: 975236 relation: main_file success: 1 - access_level: open_access checksum: 03ae30c2aa151892778e1d5be85c5722 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:32:40Z date_updated: 2025-02-27T12:32:40Z file_id: '19153' file_name: ExD10_e.png file_size: 714346 relation: main_file success: 1 - access_level: open_access checksum: a973fcca17ee02a0377a3494cafb66e9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:32:45Z date_updated: 2025-02-27T12:32:45Z file_id: '19154' file_name: ExD10_h.tif file_size: 239750348 relation: main_file success: 1 - access_level: open_access checksum: 270a780148d7bde70bcaabeeb8188559 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:23Z date_updated: 2025-02-27T12:36:23Z file_id: '19156' file_name: SF2 (1).tif file_size: 1096875 relation: main_file success: 1 - access_level: open_access checksum: f095b4b71c027734f10d91dad1a90911 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19157' file_name: SF2 (2).tif file_size: 12588982 relation: main_file success: 1 - access_level: open_access checksum: 3d635b68a0790297d8e1c854924a0e4b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19158' file_name: SF2 (3).tif file_size: 1096897 relation: main_file success: 1 - access_level: open_access checksum: 233f4c55114dbf4fff623775ac7629ed content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19159' file_name: SF2 (4).tif file_size: 12583306 relation: main_file success: 1 - access_level: open_access checksum: a86fc86d60b7a43f60ed204eac15ae9e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19160' file_name: SF2 (5).tif file_size: 1091221 relation: main_file success: 1 - access_level: open_access checksum: 732a94d766c59c5bc55bfb572c24b672 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19161' file_name: SF2 (6).tif file_size: 12588974 relation: main_file success: 1 - access_level: open_access checksum: 2a566be2ea4c9fa81d078832bce4c230 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:24Z date_updated: 2025-02-27T12:36:24Z file_id: '19162' file_name: SF2 (7).tif file_size: 1096889 relation: main_file success: 1 - access_level: open_access checksum: f262512298c9c8ca3d9e00dcd3a86b44 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:25Z date_updated: 2025-02-27T12:36:25Z file_id: '19163' file_name: SF2 (8).tif file_size: 12588960 relation: main_file success: 1 - access_level: open_access checksum: 40ce5647c948013a5f5442fdc7ac0ad2 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:36Z date_updated: 2025-02-27T12:36:36Z file_id: '19164' file_name: SF3 (1).tif file_size: 12589182 relation: main_file success: 1 - access_level: open_access checksum: 54f91d6ba3eb8e32779705e2eff261d3 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:36Z date_updated: 2025-02-27T12:36:36Z file_id: '19165' file_name: SF3 (2).tif file_size: 12589224 relation: main_file success: 1 - access_level: open_access checksum: ce8aa0f3bb62f1f29d138707cb6ced3c content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:36Z date_updated: 2025-02-27T12:36:36Z file_id: '19166' file_name: SF3 (3).tif file_size: 12589178 relation: main_file success: 1 - access_level: open_access checksum: 00169473fb4fe3d28b38755a4757bc62 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:40Z date_updated: 2025-02-27T12:36:40Z file_id: '19167' file_name: SF3 (4).tif file_size: 12589180 relation: main_file success: 1 - access_level: open_access checksum: 2e3304c513266b6d88fdcdd950e5b1c7 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:40Z date_updated: 2025-02-27T12:36:40Z file_id: '19168' file_name: SF3 (5).tif file_size: 12589270 relation: main_file success: 1 - access_level: open_access checksum: 19ca076e8bc48758af33f689d5b3fece content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:45Z date_updated: 2025-02-27T12:36:45Z file_id: '19169' file_name: SF3 (6).tif file_size: 12583264 relation: main_file success: 1 - access_level: open_access checksum: f1257eb05a38cb93c07deb98ac6bacdb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:45Z date_updated: 2025-02-27T12:36:45Z file_id: '19170' file_name: SF3 (7).tif file_size: 12589292 relation: main_file success: 1 - access_level: open_access checksum: ba6747859b2c7564b1c6fd826ed1d16e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:49Z date_updated: 2025-02-27T12:36:49Z file_id: '19171' file_name: SF3 (8).tif file_size: 12589318 relation: main_file success: 1 - access_level: open_access checksum: b7b9a7cb86b74ed201b3e7f2ace5699c content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:49Z date_updated: 2025-02-27T12:36:49Z file_id: '19172' file_name: SF3 (9).tif file_size: 12589530 relation: main_file success: 1 - access_level: open_access checksum: ebd6ecf4e7054de8661df83045e0a24c content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:09Z date_updated: 2025-02-27T12:37:09Z file_id: '19173' file_name: SF3 (10).tif file_size: 12589334 relation: main_file success: 1 - access_level: open_access checksum: 0269d65803ad587ae5d12d67df645f8b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:54Z date_updated: 2025-02-27T12:36:54Z file_id: '19174' file_name: SF3 (11).tif file_size: 12589540 relation: main_file success: 1 - access_level: open_access checksum: cd43ef86a3853e1b18da109f50d4d8ac content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:58Z date_updated: 2025-02-27T12:36:58Z file_id: '19175' file_name: SF3 (12).tif file_size: 12589296 relation: main_file success: 1 - access_level: open_access checksum: 77509629a7d63427fe188cd893174c50 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:58Z date_updated: 2025-02-27T12:36:58Z file_id: '19176' file_name: SF3 (13).tif file_size: 12589300 relation: main_file success: 1 - access_level: open_access checksum: 5b2a4870ada42b714a8d0cb3b0a22897 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:59Z date_updated: 2025-02-27T12:36:59Z file_id: '19177' file_name: SF3 (14).tif file_size: 12589228 relation: main_file success: 1 - access_level: open_access checksum: d45667253f1fc955141b92e71c3ec0f1 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:36:59Z date_updated: 2025-02-27T12:36:59Z file_id: '19178' file_name: SF3 (15).tif file_size: 12589230 relation: main_file success: 1 - access_level: open_access checksum: 82e507681c2a8ee6a5fb5ebcbcb2eda1 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:34Z date_updated: 2025-02-27T12:37:34Z file_id: '19179' file_name: SF4_d (1).tif file_size: 12595602 relation: main_file success: 1 - access_level: open_access checksum: edda9a389955107a15c762df2c1bc80b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:34Z date_updated: 2025-02-27T12:37:34Z file_id: '19180' file_name: SF4_d (2).tif file_size: 12583305 relation: main_file success: 1 - access_level: open_access checksum: 2455e23b33bab231ab3b94bb31ffff8b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:34Z date_updated: 2025-02-27T12:37:34Z file_id: '19181' file_name: SF4_d (3).tif file_size: 12595602 relation: main_file success: 1 - access_level: open_access checksum: 5970d5fe32278b3c0fdb2345d22ede22 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:34Z date_updated: 2025-02-27T12:37:34Z file_id: '19182' file_name: SF4_d (4).tif file_size: 12583305 relation: main_file success: 1 - access_level: open_access checksum: 8b19af3b6dafb364e437373beb2c8249 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:35Z date_updated: 2025-02-27T12:37:35Z file_id: '19183' file_name: SF4_d (5).tif file_size: 12583293 relation: main_file success: 1 - access_level: open_access checksum: 5948ca9e8cd4431d301829f185648e98 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:35Z date_updated: 2025-02-27T12:37:35Z file_id: '19184' file_name: SF4_d (6).tif file_size: 12595630 relation: main_file success: 1 - access_level: open_access checksum: 89f4b99ea59b28132380b573ac6872b7 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:35Z date_updated: 2025-02-27T12:37:35Z file_id: '19185' file_name: SF4_d (7).tif file_size: 12595652 relation: main_file success: 1 - access_level: open_access checksum: 37fb13a610da23d59fc8eba640417844 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:35Z date_updated: 2025-02-27T12:37:35Z file_id: '19186' file_name: SF4_d (8).tif file_size: 12595554 relation: main_file success: 1 - access_level: open_access checksum: 59355dcf56e7caca0c7ab5896d6eee19 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:50Z date_updated: 2025-02-27T12:37:50Z file_id: '19187' file_name: SF5 (1).tif file_size: 12589366 relation: main_file success: 1 - access_level: open_access checksum: 02b045794b183ca0f1a3fb7746742b11 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:50Z date_updated: 2025-02-27T12:37:50Z file_id: '19188' file_name: SF5 (2).tif file_size: 12587012 relation: main_file success: 1 - access_level: open_access checksum: e5dddad8cdca618c0cb7aa5f1b1d6f4a content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:56Z date_updated: 2025-02-27T12:37:56Z file_id: '19189' file_name: SF5 (3).tif file_size: 12589322 relation: main_file success: 1 - access_level: open_access checksum: 51a51d33c07f18777279c36498694048 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:37:56Z date_updated: 2025-02-27T12:37:56Z file_id: '19190' file_name: SF5 (4).tif file_size: 12589322 relation: main_file success: 1 - access_level: open_access checksum: f923ceac728d5ccfdfbb828615f13cbc content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:03Z date_updated: 2025-02-27T12:38:03Z file_id: '19191' file_name: SF5 (5).tif file_size: 12589322 relation: main_file success: 1 - access_level: open_access checksum: 15ab0e44297bf05ad0b033a00377bc9f content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:03Z date_updated: 2025-02-27T12:38:03Z file_id: '19192' file_name: SF5 (6).tif file_size: 12589020 relation: main_file success: 1 - access_level: open_access checksum: f79330486ce56e11e1e1e44e7425e40e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:11Z date_updated: 2025-02-27T12:38:11Z file_id: '19193' file_name: SF5 (7).tif file_size: 12589020 relation: main_file success: 1 - access_level: open_access checksum: 970e48a64b8414590606074355b67857 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:11Z date_updated: 2025-02-27T12:38:11Z file_id: '19194' file_name: SF5 (8).tif file_size: 12589372 relation: main_file success: 1 - access_level: open_access checksum: d1f671671c23159ad33d1d5ea33f84e4 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:18Z date_updated: 2025-02-27T12:38:18Z file_id: '19195' file_name: SF5 (9).tif file_size: 12589372 relation: main_file success: 1 - access_level: open_access checksum: 3e7f08d4e4c72fc5455fc5a8cb11a9eb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:18Z date_updated: 2025-02-27T12:38:18Z file_id: '19196' file_name: SF5 (10).tif file_size: 12589366 relation: main_file success: 1 - access_level: open_access checksum: 0fa65d9519b84ca6cac7767928f47620 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:38:27Z date_updated: 2025-02-27T12:38:27Z file_id: '19197' file_name: SF6_a.tif file_size: 1415036 relation: main_file success: 1 - access_level: open_access checksum: 41250d19f197453bc558d72a39523e40 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:38:28Z date_updated: 2025-02-27T12:38:28Z file_id: '19198' file_name: SF6_b.png file_size: 14771950 relation: main_file success: 1 - access_level: open_access checksum: 7ad4f1a30c7953aea60e4b5830eb00c1 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:38:28Z date_updated: 2025-02-27T12:38:28Z file_id: '19199' file_name: SF6_c.png file_size: 29541400 relation: main_file success: 1 - access_level: open_access checksum: a542e3ae50144025482e5fa6727594d6 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19200' file_name: SF7_a (1).tif file_size: 12583284 relation: main_file success: 1 - access_level: open_access checksum: f6ed6317a6d4586d5f456ca8b423f357 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:47Z date_updated: 2025-02-27T12:40:47Z file_id: '19201' file_name: SF7_a (2).tif file_size: 971691 relation: main_file success: 1 - access_level: open_access checksum: da6aef7d3b8434c7ea7e7118377cd6cb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:47Z date_updated: 2025-02-27T12:40:47Z file_id: '19202' file_name: SF7_a (3).tif file_size: 971691 relation: main_file success: 1 - access_level: open_access checksum: 0fdaca32872449bdd4773f25fedce0c2 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19203' file_name: SF7_a (4).tif file_size: 12583284 relation: main_file success: 1 - access_level: open_access checksum: 593636fa0c65b77d9909abce3bae27e6 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19204' file_name: SF7_b (1).tif file_size: 971689 relation: main_file success: 1 - access_level: open_access checksum: 008754d1e50a7f17c04ea57f3065b889 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19205' file_name: SF7_b (2).tif file_size: 971689 relation: main_file success: 1 - access_level: open_access checksum: 33c60d97c526f9f8f585b91255f0c9fb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19206' file_name: SF7_b (3).tif file_size: 12583282 relation: main_file success: 1 - access_level: open_access checksum: cdb164e16c7e9b8e81baff00570e1beb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19207' file_name: SF7_b (4).tif file_size: 12583282 relation: main_file success: 1 - access_level: open_access checksum: b406c3f975b6ee62e4a69c36a8659395 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19208' file_name: SF7_c (1).tif file_size: 971719 relation: main_file success: 1 - access_level: open_access checksum: baaf68d9c42824d2152ce347903a9e52 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19209' file_name: SF7_c (2).tif file_size: 12583312 relation: main_file success: 1 - access_level: open_access checksum: a54fa646e45ead1eca8de2cb828b6efa content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:48Z date_updated: 2025-02-27T12:40:48Z file_id: '19210' file_name: SF7_c (3).tif file_size: 971719 relation: main_file success: 1 - access_level: open_access checksum: f35b92e63a88d7dcb29399205f509058 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19211' file_name: SF7_c (4).tif file_size: 12583312 relation: main_file success: 1 - access_level: open_access checksum: f625e76556a9274e95962cc03b69c6ce content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19212' file_name: SF7_d (1).tif file_size: 971721 relation: main_file success: 1 - access_level: open_access checksum: dd38206d764413f1969dea862d0a775e content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19213' file_name: SF7_d (2).tif file_size: 12583313 relation: main_file success: 1 - access_level: open_access checksum: 891705e5dd2bcc4b761f9fe1e01fe5eb content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19214' file_name: SF7_d (3).tif file_size: 971721 relation: main_file success: 1 - access_level: open_access checksum: c0ad4758bfe9b10df96545c76ac70ae6 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:40:49Z date_updated: 2025-02-27T12:40:49Z file_id: '19215' file_name: SF7_d (4).tif file_size: 12583313 relation: main_file success: 1 - access_level: open_access checksum: f28181e59bdee004afab0d2526918892 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:44Z date_updated: 2025-02-27T12:45:44Z file_id: '19216' file_name: SF8 (1).tif file_size: 12594788 relation: main_file success: 1 - access_level: open_access checksum: 45ac190192a5067be7c21a5fd2155a16 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:44Z date_updated: 2025-02-27T12:45:44Z file_id: '19217' file_name: SF8 (2).tif file_size: 12594804 relation: main_file success: 1 - access_level: open_access checksum: df5a2f23c83ee70d29def18624700228 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:44Z date_updated: 2025-02-27T12:45:44Z file_id: '19218' file_name: SF8 (3).tif file_size: 12594768 relation: main_file success: 1 - access_level: open_access checksum: 4d7fe6b7d73527449cbadc99c6438c73 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:44Z date_updated: 2025-02-27T12:45:44Z file_id: '19219' file_name: SF8 (4).tif file_size: 12594796 relation: main_file success: 1 - access_level: open_access checksum: 96c36e0b7c0a58163a67d8bbbab93b3f content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:44Z date_updated: 2025-02-27T12:45:44Z file_id: '19220' file_name: SF8 (5).tif file_size: 12594808 relation: main_file success: 1 - access_level: open_access checksum: 68f6de9a8e37adf6c826cb0da6bb9761 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19221' file_name: SF8 (6).tif file_size: 12594788 relation: main_file success: 1 - access_level: open_access checksum: 3ded92c972cf4693929ba34af17cc05f content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19222' file_name: SF8 (7).tif file_size: 12594790 relation: main_file success: 1 - access_level: open_access checksum: b5273316902e3568be63bbced5a6bad1 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19223' file_name: SF8 (8).tif file_size: 12594782 relation: main_file success: 1 - access_level: open_access checksum: 8af6262e2f9652d25fa029981ade9de9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19224' file_name: SF8 (9).tif file_size: 12594778 relation: main_file success: 1 - access_level: open_access checksum: d643c481d2eccd5f67fb2d27223068bf content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19225' file_name: SF8 (10).tif file_size: 12594782 relation: main_file success: 1 - access_level: open_access checksum: 6d3af95382f070bb63567fbf6b3f9477 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:45Z date_updated: 2025-02-27T12:45:45Z file_id: '19226' file_name: SF8 (11).tif file_size: 12594790 relation: main_file success: 1 - access_level: open_access checksum: de12b11a75ee3fa775f144e11b68e6ed content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:46Z date_updated: 2025-02-27T12:45:46Z file_id: '19227' file_name: SF8 (12).tif file_size: 12594774 relation: main_file success: 1 - access_level: open_access checksum: 9b79caefb934a8280adcf21b5bbf35ac content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:46Z date_updated: 2025-02-27T12:45:46Z file_id: '19228' file_name: SF8 (13).tif file_size: 12594778 relation: main_file success: 1 - access_level: open_access checksum: 8e9442cdbd92fd61aacac52c23ca6bec content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:46Z date_updated: 2025-02-27T12:45:46Z file_id: '19229' file_name: SF8 (14).tif file_size: 12594790 relation: main_file success: 1 - access_level: open_access checksum: e42c08a6325e82d508221e896bd4f210 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:46Z date_updated: 2025-02-27T12:45:46Z file_id: '19230' file_name: SF8 (15).tif file_size: 12594782 relation: main_file success: 1 - access_level: open_access checksum: 04657cd0f303f99009cb1c5d4c61551c content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:58Z date_updated: 2025-02-27T12:45:58Z file_id: '19231' file_name: SF9_a (1).tif file_size: 12589358 relation: main_file success: 1 - access_level: open_access checksum: 512247c4f80abeafe17438584f23e09b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:58Z date_updated: 2025-02-27T12:45:58Z file_id: '19232' file_name: SF9_a (2).tif file_size: 977761 relation: main_file success: 1 - access_level: open_access checksum: 3c85543205b21d49dbd99edbc455fc32 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:58Z date_updated: 2025-02-27T12:45:58Z file_id: '19233' file_name: SF9_a (3).tif file_size: 12589346 relation: main_file success: 1 - access_level: open_access checksum: 3cb358e1abafb929493bba73bfef88a4 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:58Z date_updated: 2025-02-27T12:45:58Z file_id: '19234' file_name: SF9_a (4).tif file_size: 977781 relation: main_file success: 1 - access_level: open_access checksum: d025b195001165d7a1d44af9ad631ab9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19235' file_name: SF9_a (5).tif file_size: 12589366 relation: main_file success: 1 - access_level: open_access checksum: 3f2fb7ce9bf45cfadce35115c12099fd content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19236' file_name: SF9_a (6).tif file_size: 977773 relation: main_file success: 1 - access_level: open_access checksum: 6fbe1dc7c358f988280c4f8ef04f5be9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19237' file_name: SF9_b (1).tif file_size: 977781 relation: main_file success: 1 - access_level: open_access checksum: c02b2420d26ec644e86c569ede14c5ef content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19238' file_name: SF9_b (2).tif file_size: 12589366 relation: main_file success: 1 - access_level: open_access checksum: 0ed660389a060890edb85249d468a014 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19239' file_name: SF9_b (3).tif file_size: 977769 relation: main_file success: 1 - access_level: open_access checksum: cabf39d2b5d35cd3e5854b3b16001e08 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19240' file_name: SF9_b (4).tif file_size: 12589354 relation: main_file success: 1 - access_level: open_access checksum: d81c3fce4bd6e2e0109f62efb2b54959 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19241' file_name: SF9_b (5).tif file_size: 977871 relation: main_file success: 1 - access_level: open_access checksum: 374f2e897f46f6feac9feca0fa8394cd content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:45:59Z date_updated: 2025-02-27T12:45:59Z file_id: '19242' file_name: SF9_b (6).tif file_size: 12589456 relation: main_file success: 1 - access_level: open_access checksum: 84a880d60f767cfe0665ea2ec595c8d7 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:27Z date_updated: 2025-02-27T12:46:27Z file_id: '19243' file_name: SF11.tif file_size: 827856876 relation: main_file success: 1 - access_level: open_access checksum: d18add0f9f824700d0f53d2191466300 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:38Z date_updated: 2025-02-27T12:46:38Z file_id: '19244' file_name: SF12_a (1).tif file_size: 3828230 relation: main_file success: 1 - access_level: open_access checksum: 042d241d8b3080c8c5ff0a2dbda4a48f content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:38Z date_updated: 2025-02-27T12:46:38Z file_id: '19245' file_name: SF12_a (2).tif file_size: 160112 relation: main_file success: 1 - access_level: open_access checksum: 955d474f43d115fedca614ed6602215f content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:38Z date_updated: 2025-02-27T12:46:38Z file_id: '19246' file_name: SF12_a (3).tif file_size: 3828230 relation: main_file success: 1 - access_level: open_access checksum: 325f940b56634b1c33e491dcc58b3404 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:38Z date_updated: 2025-02-27T12:46:38Z file_id: '19247' file_name: SF12_a (4).tif file_size: 160112 relation: main_file success: 1 - access_level: open_access checksum: 1b5524fb3d54489b04afe9f2f7cfebb9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:39Z date_updated: 2025-02-27T12:46:39Z file_id: '19248' file_name: SF12_b (1).tif file_size: 3821356 relation: main_file success: 1 - access_level: open_access checksum: bacb9f4b367c2425df02ad392028e574 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:39Z date_updated: 2025-02-27T12:46:39Z file_id: '19249' file_name: SF12_b (2).tif file_size: 3821356 relation: main_file success: 1 - access_level: open_access checksum: 5cb107bed602073a51a534ceb4c81362 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:39Z date_updated: 2025-02-27T12:46:39Z file_id: '19250' file_name: SF12_b (3).tif file_size: 3821356 relation: main_file success: 1 - access_level: open_access checksum: 26a07d639182a4189650f4c7dba90865 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:39Z date_updated: 2025-02-27T12:46:39Z file_id: '19251' file_name: SF12_b (4).tif file_size: 3821356 relation: main_file success: 1 - access_level: open_access checksum: eba866000a286254545c3f6868f69b9f content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19252' file_name: SF18_a (1).png file_size: 1245061 relation: main_file success: 1 - access_level: open_access checksum: 8e6c94f552e9dbc34cd0b3853df8d015 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19253' file_name: SF18_a (2).tif file_size: 60892 relation: main_file success: 1 - access_level: open_access checksum: 079d6c3e2459c71ed27bc3baafa47843 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19254' file_name: SF18_a (3).tif file_size: 60892 relation: main_file success: 1 - access_level: open_access checksum: 22602da6be439acf8c3dfbb78fcc4400 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19255' file_name: SF18_b (1).tif file_size: 12583312 relation: main_file success: 1 - access_level: open_access checksum: eed1e333701f9085d69d5239e8719112 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19256' file_name: SF18_b (2).tif file_size: 811600 relation: main_file success: 1 - access_level: open_access checksum: 2215b02b1b947caf92e1bbe7185d06e1 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:46:51Z date_updated: 2025-02-27T12:46:51Z file_id: '19257' file_name: SF18_b (3).tif file_size: 811600 relation: main_file success: 1 - access_level: open_access checksum: 292e06efed5701eae8e83e02ed7a6e22 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:47:31Z date_updated: 2025-02-27T12:47:31Z file_id: '19258' file_name: SF20.tif file_size: 1068146032 relation: main_file success: 1 - access_level: open_access checksum: 32cbaee7cb8e3ce9385d716b7a54a4bc content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19259' file_name: SF23 (1).png file_size: 219654 relation: main_file success: 1 - access_level: open_access checksum: e0bbf151a4bd261a5cb1c00bed59777d content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19260' file_name: SF23 (2).png file_size: 1941088 relation: main_file success: 1 - access_level: open_access checksum: 73ed6c45b7db745252b61d24f8c40f6f content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19261' file_name: SF23 (3).png file_size: 238170 relation: main_file success: 1 - access_level: open_access checksum: c871ee6bc9d16b551582ec22b8e1a3bb content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19262' file_name: SF23 (4).png file_size: 2026158 relation: main_file success: 1 - access_level: open_access checksum: 448a0397c431153bdf63b0844842feb9 content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19263' file_name: SF23 (5).png file_size: 262037 relation: main_file success: 1 - access_level: open_access checksum: b35f44db5058569ec21550b369beec4b content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:48:36Z date_updated: 2025-02-27T12:48:36Z file_id: '19264' file_name: SF23 (6).png file_size: 2052749 relation: main_file success: 1 - access_level: open_access checksum: 5dcac37bab7e128a04ba9cdb9b34164f content_type: image/png creator: ckreuzin date_created: 2025-02-27T12:49:07Z date_updated: 2025-02-27T12:49:07Z file_id: '19265' file_name: SF23_overview.png file_size: 80062038 relation: main_file success: 1 - access_level: open_access checksum: 032c7c52f36298252cc0b19b83ea0648 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:49:50Z date_updated: 2025-02-27T12:49:50Z file_id: '19266' file_name: SF24 (1).tif file_size: 121784120 relation: main_file success: 1 - access_level: open_access checksum: 5867b6b999d0c3d91354d92ba0d6c30b content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:49:50Z date_updated: 2025-02-27T12:49:50Z file_id: '19267' file_name: SF24 (2).tif file_size: 121784062 relation: main_file success: 1 - access_level: open_access checksum: bbf1267c8030894e846f2dc95a955014 content_type: image/tiff creator: ckreuzin date_created: 2025-02-27T12:51:29Z date_updated: 2025-02-27T12:51:29Z file_id: '19268' file_name: SF25.tif file_size: 2995439929 relation: main_file success: 1 - access_level: open_access checksum: 3db644adb7181eef3181e1c418856741 content_type: image/tiff creator: ckreuzin date_created: 2025-02-28T09:07:23Z date_updated: 2025-02-28T09:07:23Z file_id: '19269' file_name: LICONN_gephyrin_test.tif file_size: 2400199306 relation: main_file success: 1 - access_level: open_access checksum: 0d716ad1249be4de51e79b6d832340b9 content_type: image/tiff creator: ckreuzin date_created: 2025-02-28T09:15:48Z date_updated: 2025-02-28T09:15:48Z file_id: '19270' file_name: LICONN_test_dataset.tif file_size: 588107137 relation: main_file success: 1 file_date_updated: 2025-02-28T16:50:39Z has_accepted_license: '1' license: https://creativecommons.org/licenses/by-nc-sa/4.0/ month: '03' oa: 1 oa_version: Published Version publisher: Institute of Science and Technology Austria related_material: link: - description: Original datasets of large size (>10GB) and datasets in zarr/n5/ims/npz format are provided via this external link. relation: research_data url: https://pub.ista.ac.at/group_danzl/data/LICONN/ record: - id: '19704' relation: used_in_publication status: public status: public title: Light-microscopy based connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19003' abstract: - lang: eng text: 'Super-resolution methods provide far better spatial resolution than the optical diffraction limit of about half the wavelength of light (∼200-300 nm). Nevertheless, they have yet to attain widespread use in plants, largely due to plants’ challenging optical properties. Expansion microscopy improves effective resolution by isotropically increasing the physical distances between sample structures while preserving relative spatial arrangements and clearing the sample. However, its application to plants has been hindered by the rigid, mechanically cohesive structure of plant tissues. Here, we report on whole-mount expansion microscopy of thale cress (Arabidopsis thaliana) root tissues (PlantEx), achieving a four-fold resolution increase over conventional microscopy. Our results highlight the microtubule cytoskeleton organization and interaction between molecularly defined cellular constituents. Combining PlantEx with stimulated emission depletion (STED) microscopy, we increase nanoscale resolution and visualize the complex organization of subcellular organelles from intact tissues by example of the densely packed COPI-coated vesicles associated with the Golgi apparatus and put these into a cellular structural context. Our results show that expansion microscopy can be applied to increase effective imaging resolution in Arabidopsis root specimens. ' acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: E-Lib - _id: M-Shop acknowledgement: "We gratefully acknowledge support by the Scientific Service Units at ISTA, including the Imaging and Optics and Lab Support facilities and the mechanical workshop and Library. We thank Philipp Velicky for STED microscope alignment.\r\nThis project has received funding from the European Research Council under the Horizon 2020 Framework Programme (grant agreement No 742985, J.F.). It has also received funding from the Horizon 2020 Framework Programme under the Marie Skłodowska-Curie Grant Agreement No. 665385 (M.G.). S.T. has received funding as an ISTplus Fellow from the Horizon 2020 Framework Programme under Marie Skłodowska-Curie grant agreement no. 754411 and from EMBO via a Long-Term Fellowship (grant number ALTF 679-2018). M.R.T. received funding from the Austrian Academy of Sciences with DOC fellowship no. 26137. The project has further received funding from the Austrian Science Fund, via grant DK W1232 (M.R.T., N.A.D., and J.G.D). W.J. received a postdoctoral fellowship from the Human Frontier Science Program (LT000557/2018). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript." article_number: koaf006 article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Michelle C full_name: Gallei, Michelle C id: 35A03822-F248-11E8-B48F-1D18A9856A87 last_name: Gallei orcid: 0000-0003-1286-7368 - first_name: Sven M full_name: Truckenbrodt, Sven M id: 45812BD4-F248-11E8-B48F-1D18A9856A87 last_name: Truckenbrodt - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Syamala full_name: Inumella, Syamala id: F8660870-D756-11E9-98C5-34DFE5697425 last_name: Inumella orcid: 0009-0002-5890-120X - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Wiebke full_name: Jahr, Wiebke id: 425C1CE8-F248-11E8-B48F-1D18A9856A87 last_name: Jahr orcid: 0000-0003-0201-2315 - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Alexander J full_name: Johnson, Alexander J id: 46A62C3A-F248-11E8-B48F-1D18A9856A87 last_name: Johnson orcid: 0000-0002-2739-8843 - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Gallei MC, Truckenbrodt SM, Kreuzinger C, et al. Super-resolution expansion microscopy in plant roots. The Plant Cell. 2025;37(4). doi:10.1093/plcell/koaf006 apa: Gallei, M. C., Truckenbrodt, S. M., Kreuzinger, C., Inumella, S., Vistunou, V., Sommer, C. M., … Danzl, J. G. (2025). Super-resolution expansion microscopy in plant roots. The Plant Cell. Oxford University Press. https://doi.org/10.1093/plcell/koaf006 chicago: Gallei, Michelle C, Sven M Truckenbrodt, Caroline Kreuzinger, Syamala Inumella, Vitali Vistunou, Christoph M Sommer, Mojtaba Tavakoli, et al. “Super-Resolution Expansion Microscopy in Plant Roots.” The Plant Cell. Oxford University Press, 2025. https://doi.org/10.1093/plcell/koaf006. ieee: M. C. Gallei et al., “Super-resolution expansion microscopy in plant roots,” The Plant Cell, vol. 37, no. 4. Oxford University Press, 2025. ista: Gallei MC, Truckenbrodt SM, Kreuzinger C, Inumella S, Vistunou V, Sommer CM, Tavakoli M, Agudelo Duenas N, Vorlaufer J, Jahr W, Randuch M, Johnson AJ, Benková E, Friml J, Danzl JG. 2025. Super-resolution expansion microscopy in plant roots. The Plant Cell. 37(4), koaf006. mla: Gallei, Michelle C., et al. “Super-Resolution Expansion Microscopy in Plant Roots.” The Plant Cell, vol. 37, no. 4, koaf006, Oxford University Press, 2025, doi:10.1093/plcell/koaf006. short: M.C. Gallei, S.M. Truckenbrodt, C. Kreuzinger, S. Inumella, V. Vistunou, C.M. Sommer, M. Tavakoli, N. Agudelo Duenas, J. Vorlaufer, W. Jahr, M. Randuch, A.J. Johnson, E. Benková, J. Friml, J.G. Danzl, The Plant Cell 37 (2025). corr_author: '1' date_created: 2025-02-05T06:52:06Z date_published: 2025-04-01T00:00:00Z date_updated: 2026-06-10T08:30:19Z day: '01' ddc: - '580' department: - _id: EvBe - _id: JoDa - _id: JiFr doi: 10.1093/plcell/koaf006 ec_funded: 1 external_id: isi: - '001462763100001' pmid: - '39792900' file: - access_level: open_access checksum: 9d3f8218ff37a29f29c48a7bbe831bd3 content_type: application/pdf creator: dernst date_created: 2025-07-31T07:03:43Z date_updated: 2025-07-31T07:03:43Z file_id: '20092' file_name: 2025_PlantCell_Gallei.pdf file_size: 53904111 relation: main_file success: 1 file_date_updated: 2025-07-31T07:03:43Z has_accepted_license: '1' intvolume: ' 37' isi: 1 issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 261099A6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742985' name: Tracing Evolution of Auxin Transport and Polarity in Plants - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 260C2330-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '754411' name: ISTplus - Postdoctoral Fellowships - _id: 269B5B22-B435-11E9-9278-68D0E5697425 grant_number: ALTF 679-2018 name: UltraX - achieving sub-nanometer resolution in light microscopy using iterative X10 microscopy in combination with nanobodies and STED - _id: 6285a163-2b32-11ec-9570-8e204ca2dba5 grant_number: '26137' name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets publication: The Plant Cell publication_identifier: eissn: - 1532-298X issn: - 1040-4651 publication_status: published publisher: Oxford University Press quality_controlled: '1' related_material: record: - id: '18689' relation: earlier_version status: public - id: '18837' relation: research_data status: public scopus_import: '1' status: public title: Super-resolution expansion microscopy in plant roots tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 37 year: '2025' ... --- OA_place: publisher _id: '19048' abstract: - lang: eng text: 'Rotations are found in physics problems at all scales: from spatial motion of celestial bodies, to transitions between quantum states of atoms and molecules. Mathematically, they represent a fundamental class of transformations and symmetries. Unlike spatial displacements, rotational transformations in three-dimensional space are non-commutative: the result of applying a sequence of rotations depends on the order of these operations. This feature makes the emergent physics that involves rotations rather intricate, but instrumental for studies of highly-interconnected many-body systems. In the presence of an environment, rotational properties of an object change, due to the interaction with particles of the environment. Owing to the complexity of this interaction, it can be engineered to exhibit certain properties of interest. In this Thesis, we examine several scenarios of how the rotational behavior of an impurity can be modified by interactions with its environment.' acknowledged_ssus: - _id: CampIT - _id: E-Lib - _id: SSU acknowledgement: "I am grateful to the European Research Council (ERC) [10.3030/801770] and Austrian\r\nScience Fund (FWF) [10.55776/F1004] for funding my research and to the Physical\r\nReview journals for publishing it. I also want to thank the VCQ (previously CoQuS) and\r\nIQOQI for organizing wonderful networking events for the physics community in Vienna\r\nand Innsbruck, respectively. Moreover, I thank Austrian Science Fund (FWF) for the\r\ncontinuous support for quantum research." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Mikhail full_name: Maslov, Mikhail id: 2E65BB0E-F248-11E8-B48F-1D18A9856A87 last_name: Maslov orcid: 0000-0003-4074-2570 citation: ama: Maslov M. Emergent physics of rotating quantum impurities in many-body environments. 2025. doi:10.15479/at:ista:19048 apa: Maslov, M. (2025). Emergent physics of rotating quantum impurities in many-body environments. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:19048 chicago: Maslov, Mikhail. “Emergent Physics of Rotating Quantum Impurities in Many-Body Environments.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/at:ista:19048. ieee: M. Maslov, “Emergent physics of rotating quantum impurities in many-body environments,” Institute of Science and Technology Austria, 2025. ista: Maslov M. 2025. Emergent physics of rotating quantum impurities in many-body environments. Institute of Science and Technology Austria. mla: Maslov, Mikhail. Emergent Physics of Rotating Quantum Impurities in Many-Body Environments. Institute of Science and Technology Austria, 2025, doi:10.15479/at:ista:19048. short: M. Maslov, Emergent Physics of Rotating Quantum Impurities in Many-Body Environments, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-02-18T01:41:27Z date_published: 2025-02-18T00:00:00Z date_updated: 2026-04-16T12:20:38Z day: '18' ddc: - '539' - '535' - '541' degree_awarded: PhD department: - _id: GradSch - _id: MiLe doi: 10.15479/at:ista:19048 ec_funded: 1 file: - access_level: open_access checksum: 5822a4dd31724c512b37c658af1787ab content_type: application/pdf creator: mmaslov date_created: 2025-02-18T14:25:59Z date_updated: 2025-02-18T14:25:59Z file_id: '19061' file_name: thesis_Maslov.pdf file_size: 7779825 relation: main_file - access_level: open_access checksum: 89bdce4774406d26ceca88a8bbcd6a9a content_type: application/zip creator: mmaslov date_created: 2025-02-18T14:25:59Z date_updated: 2025-02-18T14:25:59Z file_id: '19062' file_name: thesis_Maslov_source.zip file_size: 14453726 relation: source_file file_date_updated: 2025-02-18T14:25:59Z has_accepted_license: '1' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: '86' project: - _id: 2688CF98-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '801770' name: 'Angulon: physics and applications of a new quasiparticle' - _id: 7c040762-9f16-11ee-852c-dd79eeee4ab3 grant_number: F100403 name: Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '10845' relation: part_of_dissertation status: public - id: '7933' relation: part_of_dissertation status: public - id: '18087' relation: part_of_dissertation status: public status: public supervisor: - first_name: Mikhail full_name: Lemeshko, Mikhail id: 37CB05FA-F248-11E8-B48F-1D18A9856A87 last_name: Lemeshko orcid: 0000-0002-6990-7802 title: Emergent physics of rotating quantum impurities in many-body environments tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '19704' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of reach, owing to limitations in resolution, contrast and volumetric imaging capability. Here we describe light-microscopy-based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning-based segmentation and analysis of connectivity, thereby directly incorporating molecular information into synapse-level reconstructions of brain tissue. LICONN will allow synapse-level phenotyping of brain tissue in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: ScienComp - _id: PreCl - _id: M-Shop - _id: E-Lib acknowledgement: 'We thank S. Dorkenwald and P. Li for critical reading of the manuscript, S. Loomba for discussions and E. Miguel for support with data handling. We acknowledge support from ISTA’s scientific service units: Imaging and Optics, Lab Support, Scientific Computing, the preclinical facility, the Miba Machine Shop and the library. We acknowledge funding from the following sources: Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and M.R.T.); Austrian Academy of Sciences DOC fellowship 26137 (M.R.T.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); the European Union’s Horizon 2020 research and innovation programme and Marie Skłodowska-Curie Actions Fellowship 665385 (J.L.); and the European Union’s Horizon 2020 research and innovation programme and European Research Council (ERC) grant 101044865 ‘SecretAutism’ (G.N.).Open access funding provided by Institute of Science and Technology (IST Austria).' article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Michał full_name: Januszewski, Michał last_name: Januszewski - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Bárbara full_name: Oliveira, Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Viren full_name: Jain, Viren last_name: Jain - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 2025;642:398-410. doi:10.1038/s41586-025-08985-1 apa: Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (2025). Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-08985-1 chicago: Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature. Springer Nature, 2025. https://doi.org/10.1038/s41586-025-08985-1. ieee: M. Tavakoli et al., “Light-microscopy-based connectomic reconstruction of mammalian brain tissue,” Nature, vol. 642. Springer Nature, pp. 398–410, 2025. ista: Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. 2025. Light-microscopy-based connectomic reconstruction of mammalian brain tissue. Nature. 642, 398–410. mla: Tavakoli, Mojtaba, et al. “Light-Microscopy-Based Connectomic Reconstruction of Mammalian Brain Tissue.” Nature, vol. 642, Springer Nature, 2025, pp. 398–410, doi:10.1038/s41586-025-08985-1. short: M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, Nature 642 (2025) 398–410. corr_author: '1' date_created: 2025-05-18T22:02:51Z date_published: 2025-06-12T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '12' ddc: - '570' department: - _id: JoDa - _id: GradSch - _id: Bio - _id: GaNo doi: 10.1038/s41586-025-08985-1 ec_funded: 1 external_id: isi: - '001483477000001' pmid: - '40335689' file: - access_level: open_access checksum: ebc99d7108e728f46db0a009292675ef content_type: application/pdf creator: dernst date_created: 2025-07-03T06:55:20Z date_updated: 2025-07-03T06:55:20Z file_id: '19959' file_name: 2025_Nature_Tavakoli.pdf file_size: 133201290 relation: main_file success: 1 file_date_updated: 2025-07-03T06:55:20Z has_accepted_license: '1' intvolume: ' 642' isi: 1 language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: 398-410 pmid: 1 project: - _id: 6285a163-2b32-11ec-9570-8e204ca2dba5 grant_number: '26137' name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6 grant_number: '101044865' name: Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets publication: Nature publication_identifier: eissn: - 1476-4687 issn: - 0028-0836 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/piecing-together-the-brain-puzzle/ record: - id: '18677' relation: earlier_version status: public - id: '18697' relation: research_data status: public scopus_import: '1' status: public title: Light-microscopy-based connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd volume: 642 year: '2025' ... --- APC_amount: 3642,79 EUR DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '20080' abstract: - lang: eng text: "Introduction: Acid-growth theory has been postulated in the 70s to explain the rapid elongation of plant cells in response to the hormone auxin. More recently, it has been demonstrated that activation of the proton ATPs pump (H+-ATPs) promoting acidification of the apoplast is the principal mechanism by which auxin and other hormones such as brassinosteroids (BR) induce cell elongation. Despite these advances, the impact of this acidification on the mechanical properties of the cell wall remained largely unexplored.\r\n\r\nMethods: Here, we use elongation assays of Arabidopsis thaliana hypocotyls and Atomic Force Microscopy (AFM) to correlate hormone-induced tissue elongation and local changes in cell wall mechanical properties. Furthermore, employing transgenic lines over-expressing Pectin Methyl Esterase (PME), along with calcium chelators, we investigate the effect of pectin modification in hormone-driven cell elongation.\r\n\r\nResults: We demonstrate that acidification of apoplast is necessary and sufficient to induce cell elongation through promoting cell wall softening. Moreover, we show that enhanced PME activity can induce both cell wall softening or stiffening in extracellular calcium dependent-manner and that tight control of PME activity is required for proper hypocotyl elongation.\r\n\r\nDiscussion: Our results confirm a dual role of PME in plant cell elongation. However, further investigation is needed to assess the status of pectin following short- or long-term PME treatments in order to determine if pectin methyl-esterification might promote its degradation as well as the role of PME inhibitors upon PME induction." acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: E-Lib acknowledgement: "The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by grants from the European Research Council (Starting Independent Research Grant ERC-2007-Stg- 207362-HCPO to EB) and MG was recipient of an IST Interdisciplinary project (IC1022IPC03).\r\nWe acknowledge Jaume F. Martı́nez Garcı́a for phyAphyB mutant seeds. We acknowledge CF Nanobiotechnology of CIISB, Instruct-CZ Centre, supported by MEYS CR (LM2018127). We gratefully acknowledge support by the Scientific Service Units at ISTA, including the Imaging and Optics and Lab Support facilities and Library. We thank Stefan Riegler for the efforts to establish immunodetection method." article_number: '1612366' article_processing_charge: Yes article_type: original author: - first_name: Marçal full_name: Gallemi, Marçal id: 460C6802-F248-11E8-B48F-1D18A9856A87 last_name: Gallemi orcid: 0000-0003-4675-6893 - first_name: Juan C full_name: Montesinos López, Juan C id: 310A8E3E-F248-11E8-B48F-1D18A9856A87 last_name: Montesinos López orcid: 0000-0001-9179-6099 - first_name: Nikola full_name: Zarevski, Nikola id: 18e95355-e05a-11ea-a9c0-8fba1b89e83a last_name: Zarevski - first_name: Jan full_name: Pribyl, Jan last_name: Pribyl - first_name: Petr full_name: Skládal, Petr last_name: Skládal - first_name: Edouard B full_name: Hannezo, Edouard B id: 3A9DB764-F248-11E8-B48F-1D18A9856A87 last_name: Hannezo orcid: 0000-0001-6005-1561 - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 citation: ama: Gallemi M, Montesinos López JC, Zarevski N, et al. Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. Frontiers in Plant Science. 2025;16. doi:10.3389/fpls.2025.1612366 apa: Gallemi, M., Montesinos López, J. C., Zarevski, N., Pribyl, J., Skládal, P., Hannezo, E. B., & Benková, E. (2025). Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. Frontiers in Plant Science. Frontiers Media. https://doi.org/10.3389/fpls.2025.1612366 chicago: Gallemi, Marçal, Juan C Montesinos López, Nikola Zarevski, Jan Pribyl, Petr Skládal, Edouard B Hannezo, and Eva Benková. “Dual Role of Pectin Methyl Esterase Activity in the Regulation of Plant Cell Wall Biophysical Properties.” Frontiers in Plant Science. Frontiers Media, 2025. https://doi.org/10.3389/fpls.2025.1612366. ieee: M. Gallemi et al., “Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties,” Frontiers in Plant Science, vol. 16. Frontiers Media, 2025. ista: Gallemi M, Montesinos López JC, Zarevski N, Pribyl J, Skládal P, Hannezo EB, Benková E. 2025. Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. Frontiers in Plant Science. 16, 1612366. mla: Gallemi, Marçal, et al. “Dual Role of Pectin Methyl Esterase Activity in the Regulation of Plant Cell Wall Biophysical Properties.” Frontiers in Plant Science, vol. 16, 1612366, Frontiers Media, 2025, doi:10.3389/fpls.2025.1612366. short: M. Gallemi, J.C. Montesinos López, N. Zarevski, J. Pribyl, P. Skládal, E.B. Hannezo, E. Benková, Frontiers in Plant Science 16 (2025). corr_author: '1' date_created: 2025-07-27T22:01:26Z date_published: 2025-07-04T00:00:00Z date_updated: 2026-05-20T07:53:03Z day: '04' ddc: - '580' department: - _id: EdHa - _id: EvBe - _id: CaGu doi: 10.3389/fpls.2025.1612366 ec_funded: 1 external_id: isi: - '001530690900001' pmid: - '40688689' file: - access_level: open_access checksum: 9e6b8b53ba56d4a24a9bd91cf6d2dc58 content_type: application/pdf creator: dernst date_created: 2025-07-31T07:28:54Z date_updated: 2025-07-31T07:28:54Z file_id: '20093' file_name: 2025_FrontiersPlantSc_Gallemi.pdf file_size: 3665187 relation: main_file success: 1 file_date_updated: 2025-07-31T07:28:54Z has_accepted_license: '1' intvolume: ' 16' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 253FCA6A-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '207362' name: Hormonal cross-talk in plant organogenesis - _id: B67AFEDC-15C9-11EA-A837-991A96BB2854 name: IST Austria Open Access Fund publication: Frontiers in Plant Science publication_identifier: eissn: - 1664-462X publication_status: published publisher: Frontiers Media quality_controlled: '1' scopus_import: '1' status: public title: Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 16 year: '2025' ... --- OA_place: publisher _id: '20357' acknowledged_ssus: - _id: ScienComp - _id: E-Lib acknowledgement: "I would also like to acknowledge the Austrian Academy of Sciences for funding through the\r\nDOC Fellowship program (fellowship number 26917), the Grants Office at ISTA for their\r\nassistance with the application, and the Scientific Computing Unit for their support regarding\r\nhigh-performance computation.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Natalia full_name: Ruzickova, Natalia id: D2761128-D73D-11E9-A1BF-BA0DE6697425 last_name: Ruzickova citation: ama: Ruzickova N. Effect propagation in biological networks. 2025. doi:10.15479/AT-ISTA-20357 apa: Ruzickova, N. (2025). Effect propagation in biological networks. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20357 chicago: Ruzickova, Natalia. “Effect Propagation in Biological Networks.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20357. ieee: N. Ruzickova, “Effect propagation in biological networks,” Institute of Science and Technology Austria, 2025. ista: Ruzickova N. 2025. Effect propagation in biological networks. Institute of Science and Technology Austria. mla: Ruzickova, Natalia. Effect Propagation in Biological Networks. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20357. short: N. Ruzickova, Effect Propagation in Biological Networks, Institute of Science and Technology Austria, 2025. corr_author: '1' date_created: 2025-09-15T17:04:48Z date_published: 2025-09-15T00:00:00Z date_updated: 2026-04-07T12:02:39Z day: '15' ddc: - '570' - '530' degree_awarded: PhD department: - _id: GradSch - _id: GaTk doi: 10.15479/AT-ISTA-20357 file: - access_level: closed checksum: 991e81bc16a76b4e0c352567728fd2c5 content_type: application/pdf creator: nruzicko date_created: 2025-09-16T12:56:06Z date_updated: 2025-11-27T10:00:25Z embargo: 2026-09-14 embargo_to: open_access file_id: '20360' file_name: 2025_Ruzickova_Natalia_Thesis.pdf file_size: 43518367 relation: main_file title: Effect propagation in biological networks - access_level: closed checksum: c4ab257adad116083d8a97fac69b2dde content_type: application/zip creator: nruzicko date_created: 2025-09-16T12:59:23Z date_updated: 2025-09-16T12:59:23Z file_id: '20361' file_name: 2025_Ruzickova_Natalia_Thesis_source.zip file_size: 53464789 relation: source_file file_date_updated: 2025-11-27T10:00:25Z has_accepted_license: '1' keyword: - gene regulation - networks - omnigenic model - pancreas - collective behaviour language: - iso: eng month: '09' oa_version: Published Version page: '160' project: - _id: 7bec9174-9f16-11ee-852c-ded9fe5f810e name: Collective behaviour of cells in pancreatic Islets of Langerhans publication_identifier: isbn: - 978-3-99078-066-4 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '18525' relation: part_of_dissertation status: public status: public supervisor: - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: 0000-0002-6699-1455 title: Effect propagation in biological networks type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2025' ... --- OA_place: publisher OA_type: hybrid _id: '14257' abstract: - lang: eng text: Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease. acknowledged_ssus: - _id: ScienComp - _id: Bio - _id: PreCl - _id: LifeSc - _id: M-Shop - _id: E-Lib acknowledgement: 'We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).' article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Julia M full_name: Michalska, Julia M id: 443DB6DE-F248-11E8-B48F-1D18A9856A87 last_name: Michalska orcid: 0000-0003-3862-1235 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Philipp full_name: Velicky, Philipp id: 39BDC62C-F248-11E8-B48F-1D18A9856A87 last_name: Velicky orcid: 0000-0002-2340-7431 - first_name: Hana full_name: Korinkova, Hana id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed last_name: Korinkova - first_name: Jake full_name: Watson, Jake id: 63836096-4690-11EA-BD4E-32803DDC885E last_name: Watson orcid: 0000-0002-8698-3823 - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Nicole full_name: Amberg, Nicole id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87 last_name: Amberg orcid: 0000-0002-3183-8207 - first_name: Alessandro full_name: Venturino, Alessandro id: 41CB84B2-F248-11E8-B48F-1D18A9856A87 last_name: Venturino orcid: 0000-0003-2356-9403 - first_name: Karl full_name: Roessler, Karl last_name: Roessler - first_name: Thomas full_name: Czech, Thomas last_name: Czech - first_name: Romana full_name: Höftberger, Romana last_name: Höftberger - first_name: Sandra full_name: Siegert, Sandra id: 36ACD32E-F248-11E8-B48F-1D18A9856A87 last_name: Siegert orcid: 0000-0001-8635-0877 - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 2024;42:1051-1064. doi:10.1038/s41587-023-01911-8 apa: Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2024). Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-023-01911-8 chicago: Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology. Springer Nature, 2024. https://doi.org/10.1038/s41587-023-01911-8. ieee: J. M. Michalska et al., “Imaging brain tissue architecture across millimeter to nanometer scales,” Nature Biotechnology, vol. 42. Springer Nature, pp. 1051–1064, 2024. ista: Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2024. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 42, 1051–1064. mla: Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology, vol. 42, Springer Nature, 2024, pp. 1051–64, doi:10.1038/s41587-023-01911-8. short: J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology 42 (2024) 1051–1064. corr_author: '1' date_created: 2023-09-03T22:01:15Z date_published: 2024-07-01T00:00:00Z date_updated: 2026-04-14T08:34:35Z day: '01' ddc: - '570' department: - _id: SaSi - _id: GaNo - _id: PeJo - _id: JoDa - _id: Bio - _id: RySh doi: 10.1038/s41587-023-01911-8 ec_funded: 1 external_id: isi: - '001065254200001' pmid: - '37653226' file: - access_level: open_access checksum: 57d5fafb16f02dcb9f7dddb1bd7e2a71 content_type: application/pdf creator: dernst date_created: 2025-01-09T07:48:01Z date_updated: 2025-01-09T07:48:01Z file_id: '18784' file_name: 2024_NatureBiotech_Michalska.pdf file_size: 26065165 relation: main_file success: 1 file_date_updated: 2025-01-09T07:48:01Z has_accepted_license: '1' intvolume: ' 42' isi: 1 language: - iso: eng month: '07' oa: 1 oa_version: Published Version page: 1051-1064 pmid: 1 project: - _id: 265CB4D0-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03600 name: Optical control of synaptic function via adhesion molecules - _id: 2548AE96-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232 name: Molecular Drug Targets - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: Synaptic communication in neuronal microcircuits - _id: 23889792-32DE-11EA-91FC-C7463DDC885E grant_number: LS18-022 name: High content imaging to decode human immune cell interactions in health and allergic disease - _id: 25444568-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715508' name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9 call_identifier: H2020 grant_number: '101026635' name: Synaptic computations of the hippocampal CA3 circuitry publication: Nature Biotechnology publication_identifier: eissn: - 1546-1696 issn: - 1087-0156 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: software url: https://github.com/danzllab/CATS record: - id: '18660' relation: dissertation_contains status: deleted - id: '13126' relation: research_data status: public - id: '18674' relation: dissertation_contains status: public scopus_import: '1' status: public title: Imaging brain tissue architecture across millimeter to nanometer scales tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 42 year: '2024' ... --- OA_place: repository _id: '18677' abstract: - lang: eng text: The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution with dense cellular labeling. Light microscopy is uniquely positioned to visualize specific molecules but dense, synapse-level circuit reconstruction by light microscopy has been out of reach due to limitations in resolution, contrast, and volumetric imaging capability. Here we developed light-microscopy based connectomics (LICONN). We integrated specifically engineered hydrogel embedding and expansion with comprehensive deep-learning based segmentation and analysis of connectivity, thus directly incorporating molecular information in synapse-level brain tissue reconstructions. LICONN will allow synapse-level brain tissue phenotyping in biological experiments in a readily adoptable manner. acknowledged_ssus: - _id: E-Lib - _id: M-Shop - _id: LifeSc - _id: Bio - _id: ScienComp acknowledgement: "We thank Sven Dorkenwald and Peter Li for critical reading of the\r\nmanuscript. We acknowledge expert support by ISTA’s scientific service units: Imaging and\r\nOptics, Lab Support, Scientific Computing, Preclinical Facility, Miba Machine Shop, and Library.\r\nWe gratefully acknowledge funding by the following sources:\r\nAustrian Science Fund (FWF) grant DK W1232 (JGD, MRT)\r\nAustrian Academy of Sciences DOC fellowship 26137 (MRT)\r\nEU Horizon 2020 program, Marie Skłodowska-Curie Actions Fellowship 665385 (JL)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research\r\nCouncil (ERC) grant 101044865 “SecretAutism.”\r\n" article_processing_charge: No author: - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Michał full_name: Januszewski, Michał last_name: Januszewski - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Bárbara full_name: Oliveira, Bárbara id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87 last_name: Oliveira - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Viren full_name: Jain, Viren last_name: Jain - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Tavakoli M, Lyudchik J, Januszewski M, et al. Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. bioRxiv. doi:10.1101/2024.03.01.582884 apa: Tavakoli, M., Lyudchik, J., Januszewski, M., Vistunou, V., Agudelo Duenas, N., Vorlaufer, J., … Danzl, J. G. (n.d.). Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. bioRxiv. https://doi.org/10.1101/2024.03.01.582884 chicago: Tavakoli, Mojtaba, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Duenas, Jakob Vorlaufer, Christoph M Sommer, et al. “Light-Microscopy Based Dense Connectomic Reconstruction of Mammalian Brain Tissue.” BioRxiv, n.d. https://doi.org/10.1101/2024.03.01.582884. ieee: M. Tavakoli et al., “Light-microscopy based dense connectomic reconstruction of mammalian brain tissue,” bioRxiv. . ista: Tavakoli M, Lyudchik J, Januszewski M, Vistunou V, Agudelo Duenas N, Vorlaufer J, Sommer CM, Kreuzinger C, Oliveira B, Cenameri A, Novarino G, Jain V, Danzl JG. Light-microscopy based dense connectomic reconstruction of mammalian brain tissue. bioRxiv, 10.1101/2024.03.01.582884. mla: Tavakoli, Mojtaba, et al. “Light-Microscopy Based Dense Connectomic Reconstruction of Mammalian Brain Tissue.” BioRxiv, doi:10.1101/2024.03.01.582884. short: M. Tavakoli, J. Lyudchik, M. Januszewski, V. Vistunou, N. Agudelo Duenas, J. Vorlaufer, C.M. Sommer, C. Kreuzinger, B. Oliveira, A. Cenameri, G. Novarino, V. Jain, J.G. Danzl, BioRxiv (n.d.). corr_author: '1' date_created: 2024-12-18T14:48:24Z date_published: 2024-07-08T00:00:00Z date_updated: 2026-04-28T13:33:34Z day: '08' department: - _id: GaNo - _id: JoDa doi: 10.1101/2024.03.01.582884 ec_funded: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2024.03.01.582884 month: '07' oa: 1 oa_version: Preprint project: - _id: 6285a163-2b32-11ec-9570-8e204ca2dba5 grant_number: '26137' name: Studying Organelle Structure and Function at Nanoscale Resolution with Expansion Microscopy - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 34ba8964-11ca-11ed-8bc3-e15864e7e9a6 grant_number: '101044865' name: Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets publication: bioRxiv publication_status: draft related_material: record: - id: '18681' relation: dissertation_contains status: public - id: '18674' relation: dissertation_contains status: public - id: '19704' relation: later_version status: public status: public title: Light-microscopy based dense connectomic reconstruction of mammalian brain tissue tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ... --- OA_place: repository _id: '18689' abstract: - lang: eng text: Multiplexed fluorescence microscopy imaging is widely used in biomedical applications. However, simultaneous imaging of multiple fluorophores can result in spectral leaks and overlapping, which greatly degrades image quality and subsequent analysis. Existing popular spectral unmixing methods are mainly based on computational intensive linear models and the performance is heavily dependent on the reference spectra, which may greatly preclude its further applications. In this paper, we propose a deep learning-based blindly spectral unmixing method, termed AutoUnmix, to imitate the physical spectral mixing process. A tranfer learning framework is further devised to allow our AutoUnmix adapting to a variety of imaging systems without retraining the network. Our proposed method has demonstrated real-time unmixing capabilities, surpassing existing methods by up to 100-fold in terms of unmixing speed. We further validate the reconstruction performance on both synthetic datasets and biological samples. The unmixing results of AutoUnmix achieve a highest SSIM of 0.99 in both three- and four-color imaging, with nearly up to 20% higher than other popular unmixing methods. Due to the desirable property of data independency and superior blind unmixing performance, we believe AutoUnmix is a powerful tool to study the interaction process of different organelles labeled by multiple fluorophores. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: M-Shop - _id: E-Lib acknowledgement: "We gratefully acknowledge support by the Scientific Service Units at ISTA, including the Imaging and Optics and Lab Support facilities and the mechanical workshop and Library. We thank Philipp Velicky for STED microscope alignment.\r\n\r\nThis project has received funding from the Austrian Science Fund (FWF): I 3630-B25 (J.G.D) and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 742985, J.F.). It has also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385. S.T. has received funding as an ISTplus Fellow from the European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie grant agreement no. 754411 and from an EMBO Long-Term Fellowship (grant number ALTF 679-2018). It has further received funding from the Austrian Science Fund (FWF) grant DK W1232 (M.T, N.A-D., J.G.D). W.J. received funding via a Human Frontier Science Program postdoctoral fellowship LT000557/2018.\r\n\r\nThe funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript." article_processing_charge: No author: - first_name: Michelle C full_name: Gallei, Michelle C id: 35A03822-F248-11E8-B48F-1D18A9856A87 last_name: Gallei orcid: 0000-0003-1286-7368 - first_name: Sven M full_name: Truckenbrodt, Sven M id: 45812BD4-F248-11E8-B48F-1D18A9856A87 last_name: Truckenbrodt - first_name: Caroline full_name: Kreuzinger, Caroline id: 382077BA-F248-11E8-B48F-1D18A9856A87 last_name: Kreuzinger - first_name: Syamala full_name: Inumella, Syamala id: F8660870-D756-11E9-98C5-34DFE5697425 last_name: Inumella orcid: 0009-0002-5890-120X - first_name: Vitali full_name: Vistunou, Vitali id: 7e146587-8972-11ed-ae7b-d7a32ea86a81 last_name: Vistunou - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Mojtaba full_name: Tavakoli, Mojtaba id: 3A0A06F4-F248-11E8-B48F-1D18A9856A87 last_name: Tavakoli orcid: 0000-0002-7667-6854 - first_name: Nathalie full_name: Agudelo Duenas, Nathalie id: 40E7F008-F248-11E8-B48F-1D18A9856A87 last_name: Agudelo Duenas - first_name: Jakob full_name: Vorlaufer, Jakob id: 937696FA-C996-11E9-8C7C-CF13E6697425 last_name: Vorlaufer orcid: 0009-0000-7590-3501 - first_name: Wiebke full_name: Jahr, Wiebke id: 425C1CE8-F248-11E8-B48F-1D18A9856A87 last_name: Jahr orcid: 0000-0003-0201-2315 - first_name: Marek full_name: Randuch, Marek id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae last_name: Randuch - first_name: Alexander J full_name: Johnson, Alexander J id: 46A62C3A-F248-11E8-B48F-1D18A9856A87 last_name: Johnson orcid: 0000-0002-2739-8843 - first_name: Eva full_name: Benková, Eva id: 38F4F166-F248-11E8-B48F-1D18A9856A87 last_name: Benková orcid: 0000-0002-8510-9739 - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Gallei MC, Truckenbrodt SM, Kreuzinger C, et al. Super-resolution expansion microscopy in plant roots. bioRxiv. doi:10.1101/2024.02.21.581330 apa: Gallei, M. C., Truckenbrodt, S. M., Kreuzinger, C., Inumella, S., Vistunou, V., Sommer, C. M., … Danzl, J. G. (n.d.). Super-resolution expansion microscopy in plant roots. bioRxiv. https://doi.org/10.1101/2024.02.21.581330 chicago: Gallei, Michelle C, Sven M Truckenbrodt, Caroline Kreuzinger, Syamala Inumella, Vitali Vistunou, Christoph M Sommer, Mojtaba Tavakoli, et al. “Super-Resolution Expansion Microscopy in Plant Roots.” BioRxiv, n.d. https://doi.org/10.1101/2024.02.21.581330. ieee: M. C. Gallei et al., “Super-resolution expansion microscopy in plant roots,” bioRxiv. . ista: Gallei MC, Truckenbrodt SM, Kreuzinger C, Inumella S, Vistunou V, Sommer CM, Tavakoli M, Agudelo Duenas N, Vorlaufer J, Jahr W, Randuch M, Johnson AJ, Benková E, Friml J, Danzl JG. Super-resolution expansion microscopy in plant roots. bioRxiv, 10.1101/2024.02.21.581330. mla: Gallei, Michelle C., et al. “Super-Resolution Expansion Microscopy in Plant Roots.” BioRxiv, doi:10.1101/2024.02.21.581330. short: M.C. Gallei, S.M. Truckenbrodt, C. Kreuzinger, S. Inumella, V. Vistunou, C.M. Sommer, M. Tavakoli, N. Agudelo Duenas, J. Vorlaufer, W. Jahr, M. Randuch, A.J. Johnson, E. Benková, J. Friml, J.G. Danzl, BioRxiv (n.d.). corr_author: '1' date_created: 2024-12-19T12:28:00Z date_published: 2024-02-21T00:00:00Z date_updated: 2026-04-07T12:56:36Z day: '21' department: - _id: EvBe - _id: JoDa - _id: JiFr doi: 10.1101/2024.02.21.581330 ec_funded: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2024.02.21.581330 month: '02' oa: 1 oa_version: Preprint project: - _id: 261099A6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742985' name: Tracing Evolution of Auxin Transport and Polarity in Plants - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 260C2330-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '754411' name: ISTplus - Postdoctoral Fellowships - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets - _id: 269B5B22-B435-11E9-9278-68D0E5697425 grant_number: ALTF 679-2018 name: UltraX - achieving sub-nanometer resolution in light microscopy using iterative X10 microscopy in combination with nanobodies and STED publication: bioRxiv publication_status: draft related_material: record: - id: '19003' relation: later_version status: public - id: '18681' relation: dissertation_contains status: public status: public title: Super-resolution expansion microscopy in plant roots tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: preprint user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2024' ... --- OA_embargo: '12' OA_place: publisher _id: '18574' abstract: - lang: eng text: "Biological vision is unlike a camera; rather than transmitting light information faithfully, early\r\nvisual circuits process the visual scene to convey only the relevant information in an efficient\r\nmanner. Consequentially, the nature of this visual processing then depends on what is the\r\nrelevant information in a scene and on the notion of efficiency. In this work, I study how visual\r\nprocessing is modulated by two different variations in the visual scene. First, I discovered that\r\nin the mouse (Mus musculus) retina, Retinal Ganglion Cells in the upper and lower visual\r\nfield have differences in the center surround structure of their receptive fields. Comparison\r\nwith models of efficient coding show that this adaptation likely evolved to cope with the\r\nbrightness gradient from the sky to the ground that is pervasive in natural scenes. In the\r\nsecond project, I study how the downstream neurons in the Superior Colliculus dynamically\r\nchange their temporal selectivity depending on the ambient luminance and behavioral state.\r\nAs the scene gets darker or when the animal is is less aroused, the neuronal responses get\r\nlaggier, while still maintaining their relative timing with respect to the population. Overall, this\r\nwork emphasises the need to understand visual processing in the context of specific demands\r\nof the animal in its the environment. The adaptive changes in the visual system, from the\r\nretinal ganglion cells to the superior colliculus, highlight the intricate ways in which biological\r\nvision optimizes the processing of visual information.\r\n" acknowledged_ssus: - _id: Bio - _id: ScienComp - _id: PreCl - _id: LifeSc - _id: M-Shop - _id: E-Lib acknowledgement: "This work would have been impossible without the Scientific Service Units of IST Austria. The resources and expertise provided by Scientific Computing (especially Alois Schlögl), the MIBA Machine Shop (especially Todor Asenov), the Preclinical Facility (especially Freyja Langer), the Library, the Lab Support Facility and the Imaging and Optics Facility were the essential bedrock I could build upon. I would also like to thank IT support at ISTA for powering through remote work and a cyberattack.\r\nI am grateful for having been funded initially by the European Union Horizon 2020 Marie Skłodowska-Curie grant 665385 and later by Prof. Maximilian Joesch's the European Research Council Starting (756502) and Consolidator (101086580) Grants." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Divyansh full_name: Gupta, Divyansh id: 2A485EBE-F248-11E8-B48F-1D18A9856A87 last_name: Gupta orcid: 0000-0001-7400-6665 citation: ama: Gupta D. Visual adaptations to natural statistics. 2024. doi:10.15479/at:ista:18574 apa: Gupta, D. (2024). Visual adaptations to natural statistics. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:18574 chicago: Gupta, Divyansh. “Visual Adaptations to Natural Statistics.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:18574. ieee: D. Gupta, “Visual adaptations to natural statistics,” Institute of Science and Technology Austria, 2024. ista: Gupta D. 2024. Visual adaptations to natural statistics. Institute of Science and Technology Austria. mla: Gupta, Divyansh. Visual Adaptations to Natural Statistics. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:18574. short: D. Gupta, Visual Adaptations to Natural Statistics, Institute of Science and Technology Austria, 2024. corr_author: '1' date_created: 2024-11-20T21:30:44Z date_published: 2024-11-22T00:00:00Z date_updated: 2026-04-07T13:24:48Z day: '22' ddc: - '573' degree_awarded: PhD department: - _id: GradSch - _id: MaJö doi: 10.15479/at:ista:18574 ec_funded: 1 file: - access_level: closed checksum: ebb000d361c36b22ed6e639a931c6b7c content_type: application/zip creator: dgupta date_created: 2024-11-25T14:44:03Z date_updated: 2025-11-11T23:30:02Z embargo_to: open_access file_id: '18589' file_name: PhD Thesis - Divyansh Gupta.zip file_size: 75512262 relation: source_file - access_level: open_access checksum: 1282401eb71598bc311058b0fcefc6a1 content_type: application/pdf creator: dgupta date_created: 2024-11-26T11:43:19Z date_updated: 2025-11-11T23:30:02Z embargo: 2025-11-11 file_id: '18591' file_name: PDFA_PhD_Thesis___Divyansh_Gupta-26_11_24.pdf file_size: 6412619 relation: main_file file_date_updated: 2025-11-11T23:30:02Z has_accepted_license: '1' language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: '86' project: - _id: bdaf81a8-d553-11ed-ba76-c95961984540 grant_number: '101086580' name: 'Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses' - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 2634E9D2-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '756502' name: Circuits of Visual Attention publication_identifier: isbn: - 978-3-99078-050-3 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12349' relation: part_of_dissertation status: public - id: '12370' relation: research_data status: public status: public supervisor: - first_name: Maximilian A full_name: Jösch, Maximilian A id: 2BD278E6-F248-11E8-B48F-1D18A9856A87 last_name: Jösch orcid: 0000-0002-3937-1330 title: Visual adaptations to natural statistics tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2024' ... --- _id: '12817' abstract: - lang: eng text: 3D-reconstruction of living brain tissue down to individual synapse level would create opportunities for decoding the dynamics and structure-function relationships of the brain’s complex and dense information processing network. However, it has been hindered by insufficient 3D-resolution, inadequate signal-to-noise-ratio, and prohibitive light burden in optical imaging, whereas electron microscopy is inherently static. Here we solved these challenges by developing an integrated optical/machine learning technology, LIONESS (Live Information-Optimized Nanoscopy Enabling Saturated Segmentation). It leverages optical modifications to stimulated emission depletion (STED) microscopy in comprehensively, extracellularly labelled tissue and prior information on sample structure via machine learning to simultaneously achieve isotropic super-resolution, high signal-to-noise-ratio, and compatibility with living tissue. This allows dense deep-learning-based instance segmentation and 3D-reconstruction at synapse level incorporating molecular, activity, and morphodynamic information. LIONESS opens up avenues for studying the dynamic functional (nano-)architecture of living brain tissue. acknowledged_ssus: - _id: ScienComp - _id: Bio - _id: PreCl - _id: LifeSc - _id: M-Shop - _id: E-Lib acknowledgement: 'We thank J. Vorlaufer, N. Agudelo, A. Wartak for microscope maintenance and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, and M. Šuplata for hardware control support, and Márcia Cunha dos Santos for initial exploration of software. We thank Paul Henderson for advice on deep-learning training and Michael Sixt, Scott Boyd, and Tamara Weiss for discussions and critical reading of the manuscript. Luke Lavis (Janelia Research Campus) generously provided JF585-HaloTag ligand. ' article_processing_charge: No author: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Danzl JG. Research data for the publication “Dense 4D nanoscale reconstruction of living brain tissue.” 2023. doi:10.15479/AT:ISTA:12817 apa: Danzl, J. G. (2023). Research data for the publication “Dense 4D nanoscale reconstruction of living brain tissue.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:12817 chicago: Danzl, Johann G. “Research Data for the Publication ‘Dense 4D Nanoscale Reconstruction of Living Brain Tissue.’” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12817. ieee: J. G. Danzl, “Research data for the publication ‘Dense 4D nanoscale reconstruction of living brain tissue.’” Institute of Science and Technology Austria, 2023. ista: Danzl JG. 2023. Research data for the publication ‘Dense 4D nanoscale reconstruction of living brain tissue’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:12817. mla: Danzl, Johann G. Research Data for the Publication “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.” Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:12817. short: J.G. Danzl, (2023). contributor: - first_name: Philipp id: 39BDC62C-F248-11E8-B48F-1D18A9856A87 last_name: Velicky orcid: 0000-0002-2340-7431 - first_name: Eder id: 3FB91342-F248-11E8-B48F-1D18A9856A87 last_name: Miguel Villalba - first_name: Julia M id: 443DB6DE-F248-11E8-B48F-1D18A9856A87 last_name: Michalska - first_name: Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Donglai last_name: Wei - first_name: Zudi last_name: Lin - first_name: Jake id: 63836096-4690-11EA-BD4E-32803DDC885E last_name: Watson orcid: 0000-0002-8698-3823 - first_name: Jakob last_name: Troidl - first_name: Johanna last_name: Beyer - first_name: Yoav id: 43DF3136-F248-11E8-B48F-1D18A9856A87 last_name: Ben Simon - first_name: Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Wiebke id: 425C1CE8-F248-11E8-B48F-1D18A9856A87 last_name: Jahr - first_name: Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Johannes last_name: Broichhagen - first_name: 'Seth G. N. ' last_name: Grant - first_name: Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Hanspeter last_name: Pfister - first_name: Bernd id: 49876194-F248-11E8-B48F-1D18A9856A87 last_name: Bickel orcid: 0000-0001-6511-9385 corr_author: '1' date_created: 2023-04-07T11:37:40Z date_published: 2023-05-19T00:00:00Z date_updated: 2026-04-14T08:34:34Z day: '19' ddc: - '570' department: - _id: JoDa doi: 10.15479/AT:ISTA:12817 file: - access_level: open_access checksum: c1819889e72ec86ee1bba809e19739e0 content_type: text/plain creator: jdanzl date_created: 2023-05-18T17:06:12Z date_updated: 2023-05-18T17:06:12Z file_id: '13030' file_name: Readme.txt file_size: 651 relation: main_file success: 1 - access_level: open_access checksum: 8f6259fc5128ffcc0cd89d25d51995c1 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T19:51:52Z date_updated: 2023-05-18T19:51:52Z file_id: '13031' file_name: Fig1a_LIONESS.tif file_size: 347448884 relation: main_file success: 1 - access_level: open_access checksum: 204e8ef763b5a122fa95a594f5217d83 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:48:26Z date_updated: 2023-05-18T16:48:26Z file_id: '13029' file_name: Fig_1b.tif file_size: 91626 relation: main_file success: 1 - access_level: open_access checksum: dc521a4e6e80a57c100a06ba1e87c766 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:48:26Z date_updated: 2023-05-18T16:48:26Z file_id: '13028' file_name: Fig_1c.tif file_size: 90300 relation: main_file success: 1 - access_level: open_access checksum: 56d3d5dbe7e1f54dbecc32ad2d2cc6df content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:00:06Z date_updated: 2023-05-18T16:00:06Z file_id: '13022' file_name: Figure2a_low_exposure_input.tif file_size: 18391928 relation: main_file success: 1 - access_level: open_access checksum: 2c30dbd6c4db079f7fdc2eaeea5f9710 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:59:30Z date_updated: 2023-05-18T15:59:30Z file_id: '13021' file_name: Figure2a_LIONESS.tif file_size: 18392017 relation: main_file success: 1 - access_level: open_access checksum: 799868024bf734fecaf36f4ffd843ed2 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:58:54Z date_updated: 2023-05-18T15:58:54Z file_id: '13020' file_name: Figure2a_merge_LIONESS_EGFP.tif file_size: 36785440 relation: main_file success: 1 - access_level: open_access checksum: 522fe0fe505e437d6f637f9b8059dfaa content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:44:45Z date_updated: 2023-05-18T16:44:45Z file_id: '13025' file_name: Fig2c_LIONESS.tif file_size: 670051576 relation: main_file success: 1 - access_level: open_access checksum: c9c0d873341d2f974ba799fa71a1b789 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:23:10Z date_updated: 2023-05-18T16:23:10Z file_id: '13024' file_name: Fig2de_LIONESS_1.tif file_size: 412478217 relation: main_file success: 1 - access_level: open_access checksum: ff86ad8642c56ba1c67c814e20925a85 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T19:48:02Z date_updated: 2023-05-18T19:48:02Z file_id: '13032' file_name: Fig2de_LIONESS_2.tif file_size: 637360217 relation: main_file success: 1 - access_level: open_access checksum: 32681bd33673088193fad9f9c7b79090 content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:39:05Z date_updated: 2023-05-18T14:39:05Z file_id: '12995' file_name: Fig_3_LIONESS.zip file_size: 46563159 relation: main_file success: 1 - access_level: open_access checksum: 17239ed0f54ac7495e2b1daa5d0864ef content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:04:40Z date_updated: 2023-05-18T15:04:40Z file_id: '13001' file_name: Fig_4_LIONESS_synaptic_markers.zip file_size: 29159397 relation: main_file success: 1 - access_level: open_access checksum: c060c898f2bf93312a4c07dfdcb745cb content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:58:09Z date_updated: 2023-05-18T14:58:09Z file_id: '12997' file_name: Fig_5a_time_series_Ca2+_imaging.zip file_size: 16563855 relation: main_file success: 1 - access_level: open_access checksum: 85b4c0cd099212ecf0beec3a78bb35c5 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:55:44Z date_updated: 2023-05-18T15:55:44Z file_id: '13017' file_name: Fig5b_LIONESS_T1.tif file_size: 30632526 relation: main_file success: 1 - access_level: open_access checksum: eb83649a0ebc2f5ea7a0308324ebf308 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:57:40Z date_updated: 2023-05-18T15:57:40Z file_id: '13018' file_name: Fig5b_LIONESS_T2.tif file_size: 57634426 relation: main_file success: 1 - access_level: open_access checksum: 40a2d93a34f83ce37043d8414d981b3d content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:14:33Z date_updated: 2023-05-18T15:14:33Z file_id: '13005' file_name: Extended_Data_Figure 3a_low_exposure.tif file_size: 12512676 relation: main_file success: 1 - access_level: open_access checksum: 516521bb400f5c058184994b57165f8b content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:15:01Z date_updated: 2023-05-18T15:15:01Z file_id: '13006' file_name: Extended_Data_Figure 3a_high_exposure.tif file_size: 12512678 relation: main_file success: 1 - access_level: open_access checksum: 1d3a21970307de2d84b614985ec0706d content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:17:08Z date_updated: 2023-05-18T15:17:08Z file_id: '13007' file_name: Extended_Data_Figure 3a_restored.tif file_size: 50038242 relation: main_file success: 1 - access_level: open_access checksum: 441575853bf667ed89cc218079cc397b content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:56:57Z date_updated: 2023-05-18T15:56:57Z file_id: '13016' file_name: Extended_Data_Figure 3b_example dataset_low_exposure_input.tif file_size: 68298045 relation: main_file success: 1 - access_level: open_access checksum: e499355760270e14bcf12bdc7960bd7a content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:54:43Z date_updated: 2023-05-18T15:54:43Z file_id: '13015' file_name: Extended_Data_Figure 3b_example dataset_merge_LIONESS_EGFP.tif file_size: 136597524 relation: main_file success: 1 - access_level: open_access checksum: add9f1adc6763091233dbe8504f1c396 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:50:19Z date_updated: 2023-05-18T15:50:19Z file_id: '13014' file_name: Extended_Data_Figure 3b_dataset_1_merge_LIONESS_EGFP.tif file_size: 76103800 relation: main_file success: 1 - access_level: open_access checksum: 311719efb1c68d7243be557b779173f2 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:51:20Z date_updated: 2023-05-18T15:51:20Z file_id: '13013' file_name: Extended_Data_Figure 3b_dataset_2_merge_LIONESS_EGFP.tif file_size: 49810007 relation: main_file success: 1 - access_level: open_access checksum: 8d5d9d859f8d099bb3b877c4e455f699 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:32:55Z date_updated: 2023-05-18T15:32:55Z file_id: '13010' file_name: Extended_Data_Figure 3b_dataset_3_merge_LIONESS_EGFP.tif file_size: 169060658 relation: main_file success: 1 - access_level: open_access checksum: 79eca23cc5e2fc1fe26e03e1bba2e90f content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:47:03Z date_updated: 2023-05-18T15:47:03Z file_id: '13011' file_name: Extended_Data_Figure 3b_dataset_4_merge_LIONESS_EGFP.tif file_size: 169060658 relation: main_file success: 1 - access_level: open_access checksum: 107bf2e0f8a14b4bd0169c9104765171 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:47:47Z date_updated: 2023-05-18T15:47:47Z file_id: '13012' file_name: Extended_Data_Figure 3b_dataset_5_merge_LIONESS_EGFP.tif file_size: 244861000 relation: main_file success: 1 - access_level: open_access checksum: b71e4a090dd9a8048aee847ae47624f0 content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:36:34Z date_updated: 2023-05-18T14:36:34Z file_id: '12994' file_name: Extended_Data_Fig_4_LIONESS_TIF_stacks.zip file_size: 76795968 relation: main_file success: 1 - access_level: open_access checksum: ea011c3d1966ba79a62e8cf775e595c5 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:09:31Z date_updated: 2023-05-18T16:09:31Z file_id: '13023' file_name: Extended_Data_Fig5b.tif file_size: 288330201 relation: main_file success: 1 - access_level: open_access checksum: 1c56b5b324b6270b0df72a77e1e9d6f1 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:21:29Z date_updated: 2023-05-18T15:21:29Z file_id: '13003' file_name: Extended_Data_Fig_6_TIF_stacks.zip file_size: 255976297 relation: main_file success: 1 - access_level: open_access checksum: 89150ebb0044ead282b9048e55cd3961 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:08:20Z date_updated: 2023-05-18T15:08:20Z file_id: '13002' file_name: Extended_Data_Fig_7.zip file_size: 70694476 relation: main_file success: 1 - access_level: open_access checksum: 81e79a6d4e6745dce63cdad94bfcdca4 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:46:36Z date_updated: 2023-05-18T16:46:36Z file_id: '13026' file_name: Extended_Data_Fig_8b_T1.tif file_size: 57634426 relation: main_file success: 1 - access_level: open_access checksum: 53da2b10969a185239b317be0ffa61ef content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:48:26Z date_updated: 2023-05-18T16:48:26Z file_id: '13027' file_name: Extended_Data_Fig_8b_T2.tif file_size: 57634426 relation: main_file success: 1 - access_level: open_access checksum: 9a97ccd3eb0c75a5c4f142e5dadc0fb3 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:02:09Z date_updated: 2023-05-18T15:02:09Z file_id: '12999' file_name: Extended_Data_Fig_8c_png.zip file_size: 2942961 relation: main_file success: 1 - access_level: open_access checksum: baaee60e695160118ea2167c6cb91775 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:17:38Z date_updated: 2023-05-18T15:17:38Z file_id: '13008' file_name: Extended_Data_Fig9c_LIONESS.tif file_size: 11949362 relation: main_file success: 1 - access_level: open_access checksum: 095a980d0d746bc2277b0586dbb9d652 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:02:00Z date_updated: 2023-05-18T15:02:00Z file_id: '12998' file_name: Extended_Data_Fig_10_LIONESS_tif_xy_view.zip file_size: 72553526 relation: main_file success: 1 - access_level: open_access checksum: 343b87c4842eab9e5086f248668dec84 content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:22:43Z date_updated: 2023-05-18T14:22:43Z file_id: '12992' file_name: Extended_Data_Fig_10_LIONESS_tif_xz_view.zip file_size: 72906090 relation: main_file success: 1 - access_level: open_access checksum: c3d4970e5185f72cb89f36005e83a556 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:14:01Z date_updated: 2023-05-18T15:14:01Z file_id: '13004' file_name: Supplementary_Fig_4.zip file_size: 428208 relation: main_file success: 1 - access_level: open_access checksum: f451852622f8ba8992582ab9b57c49e5 content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:32:29Z date_updated: 2023-05-18T14:32:29Z file_id: '12991' file_name: Supplementary_Fig_8.zip file_size: 230506869 relation: main_file success: 1 - access_level: open_access checksum: 874b524f38fad6b86be14326bb5aa706 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T16:00:15Z date_updated: 2023-05-18T16:00:15Z file_id: '13019' file_name: Suppl_Fig_11_LIONESS.tif file_size: 40406386 relation: main_file success: 1 - access_level: open_access checksum: 7ab5cc6c581c463d1d7e430399b8b384 content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:57:18Z date_updated: 2023-05-18T14:57:18Z file_id: '12996' file_name: Supplementary_Fig_12.zip file_size: 357705621 relation: main_file success: 1 - access_level: open_access checksum: 9763330288c2d544a3e1d7bc12657ee8 content_type: image/tiff creator: jdanzl date_created: 2023-05-18T15:39:45Z date_updated: 2023-05-18T15:39:45Z file_id: '13009' file_name: Supplementary_Fig_13.tif file_size: 617709326 relation: main_file success: 1 - access_level: open_access checksum: 1e83b64e220694942ccf0ca70f17e33b content_type: application/zip creator: jdanzl date_created: 2023-05-18T14:19:48Z date_updated: 2023-05-18T14:19:48Z file_id: '12990' file_name: GCaMP_recording_overview_time_series_Suppl_Video_5.zip file_size: 9387873 relation: main_file success: 1 - access_level: open_access checksum: fc7208299e6393e69b31a0051fa5ac2e content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:13:55Z date_updated: 2023-05-18T15:13:55Z file_id: '12993' file_name: CARE model.zip file_size: 1218458059 relation: main_file success: 1 - access_level: open_access checksum: 47db2185ff2c6ba9b059c9b1a8882832 content_type: application/zip creator: jdanzl date_created: 2023-05-18T15:03:10Z date_updated: 2023-05-18T15:03:10Z file_id: '13000' file_name: Segmentation model.zip file_size: 19052980 relation: main_file success: 1 file_date_updated: 2023-05-18T19:51:52Z has_accepted_license: '1' license: https://creativecommons.org/licenses/by-sa/4.0/ month: '05' oa: 1 oa_version: Published Version publisher: Institute of Science and Technology Austria related_material: record: - id: '13267' relation: used_in_publication status: public status: public title: Research data for the publication "Dense 4D nanoscale reconstruction of living brain tissue" tmp: image: /images/cc_by_sa.png legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0) short: CC BY-SA (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2023' ... --- _id: '13126' abstract: - lang: eng text: Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here, we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease. acknowledged_ssus: - _id: ScienComp - _id: Bio - _id: PreCl - _id: LifeSc - _id: M-Shop - _id: E-Lib acknowledgement: "We thank Jakob Vorlaufer, Nathalie Agudelo-Dueñas, Wiebke Jahr, Andreas Wartak for microscope maintenance and troubleshooting, Caroline Kreuzinger, Anna Freeman, and Irene Erber for technical assistance and Matthias Tomschik for support with obtaining human samples. We gratefully acknowledge Eder Miguel for setting up webKnossos and Marek Šuplata for computational support and hardware control. We are grateful to Ryuichi Shigemoto and Bernd Bickel for generous support, and Michael Sixt and Scott Boyd (Stanford University) for discussions and critical reading of the manuscript. PSD95-HaloTag mice were kindly provided by Seth Grant (University of Edinburgh). We acknowledge expert support by IST Austria’s scientific computing, imaging and optics, preclinical, and lab support facilities, and by the Library and Miba machine shop.\r\nWe gratefully acknowledge funding by the following sources: \r\nAustrian Science Fund (FWF) grant I3600-B27 (JGD)\r\nAustrian Science Fund (FWF) grant DK W1232 (JGD, JMM)\r\nAustrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (PJ)\r\nAustrian Science Funds (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (RH)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (GN)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (PJ)\r\nMarie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (JMM, JL)\r\nMarie Skłodowska-Curie Actions Individual Fellowship 101026635 under the EU Horizon 2020 program (JFW)" article_processing_charge: No author: - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Danzl JG. Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” 2023. doi:10.15479/AT:ISTA:13126 apa: Danzl, J. G. (2023). Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:13126 chicago: Danzl, Johann G. “Research Data for the Publication ‘Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.’” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:13126. ieee: J. G. Danzl, “Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales.’” Institute of Science and Technology Austria, 2023. ista: Danzl JG. 2023. Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:13126. mla: Danzl, Johann G. Research Data for the Publication “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:13126. short: J.G. Danzl, (2023). contributor: - first_name: Julia M id: 443DB6DE-F248-11E8-B48F-1D18A9856A87 last_name: Michalska - first_name: Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Philipp id: 39BDC62C-F248-11E8-B48F-1D18A9856A87 last_name: Velicky orcid: 0000-0002-2340-7431 - first_name: Hana id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed last_name: Stefanickova - first_name: Jake id: 63836096-4690-11EA-BD4E-32803DDC885E last_name: Watson orcid: 0000-0002-8698-3823 - first_name: Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Nicole id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87 last_name: Amberg orcid: 0000-0002-3183-8207 - first_name: Alessandro id: 41CB84B2-F248-11E8-B48F-1D18A9856A87 last_name: Venturino orcid: 0000-0003-2356-9403 - first_name: Karl last_name: Roessler - first_name: Thomas last_name: Czech - first_name: Romana last_name: Höftberger - first_name: Sandra id: 36ACD32E-F248-11E8-B48F-1D18A9856A87 last_name: Siegert orcid: 0000-0001-8635-0877 - first_name: Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 corr_author: '1' date_created: 2023-06-07T07:15:12Z date_published: 2023-08-04T00:00:00Z date_updated: 2026-04-14T08:34:35Z day: '04' ddc: - '610' department: - _id: JoDa - _id: SaSi - _id: GaNo - _id: PeJo - _id: Bio - _id: RySh doi: 10.15479/AT:ISTA:13126 ec_funded: 1 file: - access_level: open_access checksum: 6f18ce9b89b47ce5abeb379869ff5c49 content_type: text/plain creator: jdanzl date_created: 2023-08-04T13:19:47Z date_updated: 2023-08-04T13:19:47Z file_id: '13961' file_name: Readme_Michalska_2023.txt file_size: 541 relation: main_file success: 1 - access_level: open_access checksum: 2098e8c5285c5e86cb69075e1b5dcf39 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:29Z date_updated: 2023-08-03T11:29:29Z file_id: '13482' file_name: Fig1_b_top-left.tif file_size: 64582744 relation: main_file success: 1 - access_level: open_access checksum: 9affab3dacf847096cc8e8d5ff99467e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:28Z date_updated: 2023-08-03T11:29:28Z file_id: '13483' file_name: Fig1_b_top-right.tif file_size: 1442113 relation: main_file success: 1 - access_level: open_access checksum: d7fec0296123a17f6bcdbfee17411424 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:29Z date_updated: 2023-08-03T11:29:29Z file_id: '13484' file_name: Fig1_c_1.tif file_size: 40078276 relation: main_file success: 1 - access_level: open_access checksum: 5195a180c4f26a7adc994bad0b3c53c7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:29Z date_updated: 2023-08-03T11:29:29Z file_id: '13485' file_name: Fig1_c_2.tif file_size: 7984315 relation: main_file success: 1 - access_level: open_access checksum: df1105d8f41ebd5373cacc597ffa91f3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:29Z date_updated: 2023-08-03T11:29:29Z file_id: '13486' file_name: Fig1_c_3.tif file_size: 8693320 relation: main_file success: 1 - access_level: open_access checksum: 00edbb0c9f42032c830d2291ec55c4c0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:30Z date_updated: 2023-08-03T11:29:30Z file_id: '13487' file_name: Fig1_c_4.tif file_size: 6003063 relation: main_file success: 1 - access_level: open_access checksum: a58399e98ec4b6506a5dae13e387f391 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:30Z date_updated: 2023-08-03T11:29:30Z file_id: '13488' file_name: Fig1_d.tif file_size: 24003063 relation: main_file success: 1 - access_level: open_access checksum: 699df4bc104df14607359678963b3d2d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:30Z date_updated: 2023-08-03T11:29:30Z file_id: '13489' file_name: Fig1_e_zoom.tif file_size: 18063 relation: main_file success: 1 - access_level: open_access checksum: ea7b1278da490d221fc7698fd6bc39a4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:29:30Z date_updated: 2023-08-03T11:29:30Z file_id: '13490' file_name: Fig1_e.tif file_size: 186813 relation: main_file success: 1 - access_level: open_access checksum: 37b05ef3a36b9f6bf4ec46199230874a content_type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet creator: jdanzl date_created: 2023-08-03T11:29:30Z date_updated: 2023-08-03T11:29:30Z file_id: '13491' file_name: Fig1_f.xlsx file_size: 17494 relation: main_file success: 1 - access_level: open_access checksum: 872eb3dc1a94afb26947a365bfae581a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:43Z date_updated: 2023-08-03T11:40:43Z file_id: '13492' file_name: Fig2_a_1.tif file_size: 816786862 relation: main_file success: 1 - access_level: open_access checksum: cab6f72d7d546a81c105c229747949ef content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:13Z date_updated: 2023-08-03T11:40:13Z file_id: '13493' file_name: Fig2_a_2.tif file_size: 8654692 relation: main_file success: 1 - access_level: open_access checksum: c85bc3ffe7f6bdf16a81290761ed6253 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:14Z date_updated: 2023-08-03T11:40:14Z file_id: '13494' file_name: Fig2_a_3.tif file_size: 8654692 relation: main_file success: 1 - access_level: open_access checksum: 5a3fd5484e566c34e210a4acb2b97791 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:24Z date_updated: 2023-08-03T11:40:24Z file_id: '13495' file_name: Fig2_a_4.tif file_size: 272262438 relation: main_file success: 1 - access_level: open_access checksum: ae5cbacf56e3fdf934a6d6fd489f5fe0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:37Z date_updated: 2023-08-03T11:40:37Z file_id: '13496' file_name: Fig2_a_5.tif file_size: 272262438 relation: main_file success: 1 - access_level: open_access checksum: e6da436b83bbe3a34138b52e5de49d69 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:44Z date_updated: 2023-08-03T11:40:44Z file_id: '13497' file_name: Fig2_a_6.tif file_size: 204301228 relation: main_file success: 1 - access_level: open_access checksum: 855f0a0bcf5b3d7cc7d50561f2c8f625 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:40:49Z date_updated: 2023-08-03T11:40:49Z file_id: '13498' file_name: Fig2_a_7-8.tif file_size: 68094350 relation: main_file success: 1 - access_level: open_access checksum: ff709f9f8ebaa8cf50a4b2fca5ce9813 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T11:40:48Z date_updated: 2023-08-03T11:40:48Z file_id: '13499' file_name: Fig2_a_roi.roi file_size: 156 relation: main_file success: 1 - access_level: open_access checksum: ce9b774ff5163ebfa4e3fb162f4cfffe content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:41:37Z date_updated: 2023-08-03T11:41:37Z file_id: '13500' file_name: Fig2_c-i_1_n2v.tif file_size: 1036927887 relation: main_file success: 1 - access_level: open_access checksum: 21f1bb8d2a00c88bdd6febe6285acc2a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:41:25Z date_updated: 2023-08-03T11:41:25Z file_id: '13501' file_name: Fig2_c-i_1.tif file_size: 518519275 relation: main_file success: 1 - access_level: open_access checksum: 9af5b66b74c2ff4b2b99b0d94f2864e6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:42:48Z date_updated: 2023-08-03T11:42:48Z file_id: '13502' file_name: Fig2_c-i_3_n2v.tif file_size: 1444202302 relation: main_file success: 1 - access_level: open_access checksum: c83261e88821747b301197314d92f2b2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:42:57Z date_updated: 2023-08-03T11:42:57Z file_id: '13503' file_name: Fig2_c-i_3.tif file_size: 1075338708 relation: main_file success: 1 - access_level: open_access checksum: 5d1278ba4b7e085c0c186ea49fce535b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:05Z date_updated: 2023-08-03T11:44:05Z file_id: '13504' file_name: Fig2_c-i_2_n2v.tif file_size: 851145493 relation: main_file success: 1 - access_level: open_access checksum: 5aaf1eba65582cf437ff3ce753eba4d7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:43:47Z date_updated: 2023-08-03T11:43:47Z file_id: '13505' file_name: Fig2_c-i_2.tif file_size: 432099834 relation: main_file success: 1 - access_level: open_access checksum: ce9b774ff5163ebfa4e3fb162f4cfffe content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:41Z date_updated: 2023-08-03T11:44:41Z file_id: '13506' file_name: Fig2_h_n2v.tif file_size: 1036927887 relation: main_file success: 1 - access_level: open_access checksum: 21f1bb8d2a00c88bdd6febe6285acc2a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:36Z date_updated: 2023-08-03T11:44:36Z file_id: '13507' file_name: Fig2_h.tif file_size: 518519275 relation: main_file success: 1 - access_level: open_access checksum: b37f25a90ef42fa4358649fdd6b41f35 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:40Z date_updated: 2023-08-03T11:44:40Z file_id: '13508' file_name: Fig2_j_1.tif file_size: 19287397 relation: main_file success: 1 - access_level: open_access checksum: 50f0969c6c2c1209ff776bec4861030a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:41Z date_updated: 2023-08-03T11:44:41Z file_id: '13509' file_name: Fig2_j_2.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 2a8cc93471378ac4c3b640e4318d89eb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:41Z date_updated: 2023-08-03T11:44:41Z file_id: '13510' file_name: Fig2_j_3.tif file_size: 19287392 relation: main_file success: 1 - access_level: open_access checksum: b90965d20133fea73c99050c32eb7695 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:42Z date_updated: 2023-08-03T11:44:42Z file_id: '13511' file_name: Fig2_j_4.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 568a1e0efaa62527b51e66a7aabfd05c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:43Z date_updated: 2023-08-03T11:44:43Z file_id: '13512' file_name: Fig2_j_coCATS_N2V.tif file_size: 19287339 relation: main_file success: 1 - access_level: open_access checksum: c70447cebe073dd78e0ac34ecc36ad85 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T11:44:44Z date_updated: 2023-08-03T11:44:44Z file_id: '13513' file_name: Fig2_j_roi.roi file_size: 148 relation: main_file success: 1 - access_level: open_access checksum: 505252cc4b443b76c2e41ecf5879a542 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:44:52Z date_updated: 2023-08-03T11:44:52Z file_id: '13514' file_name: Fig3_a_n2v.tif file_size: 316842690 relation: main_file success: 1 - access_level: open_access checksum: 35463183611e8ee4fba2025772c40eb2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:45:01Z date_updated: 2023-08-03T11:45:01Z file_id: '13515' file_name: Fig3_a.tif file_size: 172839057 relation: main_file success: 1 - access_level: open_access checksum: e0469102a87332b46904b4ba35b8fb2f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:45:05Z date_updated: 2023-08-03T11:45:05Z file_id: '13516' file_name: Fig3_g_n2v.tif file_size: 309407894 relation: main_file success: 1 - access_level: open_access checksum: 854c8fe02acd920f8e8f6a3173458e86 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:15Z date_updated: 2023-08-03T11:51:15Z file_id: '13517' file_name: Fig4_a_MIP.tif file_size: 11327792 relation: main_file success: 1 - access_level: open_access checksum: ab35811ffbe3f40733d0e054d9d6c4e6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:18Z date_updated: 2023-08-03T11:51:18Z file_id: '13518' file_name: Fig4_c_dghilus_bouton2_n2v.tif file_size: 106696700 relation: main_file success: 1 - access_level: open_access checksum: e3b6410d68e42004ef3857967707aeb3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:17Z date_updated: 2023-08-03T11:51:17Z file_id: '13519' file_name: Fig4_c_dghilus_bouton2.tif file_size: 53367287 relation: main_file success: 1 - access_level: open_access checksum: 9ef0e3f3ec6f0b7b2666e3a0d7e6f355 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:20Z date_updated: 2023-08-03T11:51:20Z file_id: '13520' file_name: Fig4_c_dghilus_bouton5_n2v.tif file_size: 103816699 relation: main_file success: 1 - access_level: open_access checksum: d5d846a4edaf0168ca6cc53d8cc39dde content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:21Z date_updated: 2023-08-03T11:51:21Z file_id: '13521' file_name: Fig4_c_dghilus_bouton5.tif file_size: 51927287 relation: main_file success: 1 - access_level: open_access checksum: 690a87182441c9742da2550189641e5a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:24Z date_updated: 2023-08-03T11:51:24Z file_id: '13522' file_name: Fig4_c_stratum_bouton11_n2v.tif file_size: 76391971 relation: main_file success: 1 - access_level: open_access checksum: 4dc575424729c5ba181bd9a3962d4781 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:23Z date_updated: 2023-08-03T11:51:23Z file_id: '13523' file_name: Fig4_c_stratum_bouton11.tif file_size: 38217920 relation: main_file success: 1 - access_level: open_access checksum: 9fdd51636928f45e8e534cc5a37a48ff content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:29Z date_updated: 2023-08-03T11:51:29Z file_id: '13524' file_name: Fig4_c_stratum_bouton13_n2v.tif file_size: 154149020 relation: main_file success: 1 - access_level: open_access checksum: 643169464252d67753ac6f8493668f34 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:28Z date_updated: 2023-08-03T11:51:28Z file_id: '13525' file_name: Fig4_c_stratum_bouton13.tif file_size: 77099447 relation: main_file success: 1 - access_level: open_access checksum: ab35811ffbe3f40733d0e054d9d6c4e6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:32Z date_updated: 2023-08-03T11:51:32Z file_id: '13526' file_name: Fig4_d.tif file_size: 106696700 relation: main_file success: 1 - access_level: open_access checksum: 9fdd51636928f45e8e534cc5a37a48ff content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:35Z date_updated: 2023-08-03T11:51:35Z file_id: '13527' file_name: Fig4_e.tif file_size: 154149020 relation: main_file success: 1 - access_level: open_access checksum: 5380d0a98e97d7d8462b38bd0a96644c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:32Z date_updated: 2023-08-03T11:51:32Z file_id: '13528' file_name: Fig4_f_1_top.tif file_size: 5986760 relation: main_file success: 1 - access_level: open_access checksum: 7d1309e806eb31588ebafcf40388e13f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:33Z date_updated: 2023-08-03T11:51:33Z file_id: '13529' file_name: Fig4_f_2_top.tif file_size: 6001178 relation: main_file success: 1 - access_level: open_access checksum: a71c80207655d508cbc7626bc144d7a1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:33Z date_updated: 2023-08-03T11:51:33Z file_id: '13530' file_name: Fig4_f_3_top.tif file_size: 6023318 relation: main_file success: 1 - access_level: open_access checksum: 5d76b2ad7d7acbb1afa27cf52194b1cb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13531' file_name: Fig4_f_4_top.tif file_size: 6038186 relation: main_file success: 1 - access_level: open_access checksum: 9cee6b3387bd880843f2c6cdfa0d4a8d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13532' file_name: Fig4_f_5_top.tif file_size: 2324158 relation: main_file success: 1 - access_level: open_access checksum: a48fc9e1bb2710cf28466ae6d2a20c19 content_type: image/png creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13533' file_name: Fig4_f_1_bottom.png file_size: 1150264 relation: main_file success: 1 - access_level: open_access checksum: ff47ca30f814e17561974b73b0913a1a content_type: image/png creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13534' file_name: Fig4_f_2_bottom.png file_size: 1157424 relation: main_file success: 1 - access_level: open_access checksum: 2ea3fb8d79cee8ae9de7ca31d003910f content_type: image/png creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13535' file_name: Fig4_f_3_bottom.png file_size: 1152715 relation: main_file success: 1 - access_level: open_access checksum: d25e5ecf2f0c3be7c20a7e25a7a334b8 content_type: image/png creator: jdanzl date_created: 2023-08-03T11:51:34Z date_updated: 2023-08-03T11:51:34Z file_id: '13536' file_name: Fig4_f_4_bottom.png file_size: 1105240 relation: main_file success: 1 - access_level: open_access checksum: 76535f569a57b967e378df89b7d2982a content_type: image/png creator: jdanzl date_created: 2023-08-03T11:51:35Z date_updated: 2023-08-03T11:51:35Z file_id: '13537' file_name: Fig4_f_5_bottom.png file_size: 1228157 relation: main_file success: 1 - access_level: open_access checksum: d46fefe73daa3ec08b847631e9de6828 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:52Z date_updated: 2023-08-03T11:53:52Z file_id: '13538' file_name: Fig5_a_1.tif file_size: 91181184 relation: main_file success: 1 - access_level: open_access checksum: 354c0ba876a33672eca37cd61dac7073 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:54Z date_updated: 2023-08-03T11:53:54Z file_id: '13539' file_name: Fig5_a_2.tif file_size: 176024124 relation: main_file success: 1 - access_level: open_access checksum: d07925040ef0c3c51edbdca8cf3ec1fa content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:53Z date_updated: 2023-08-03T11:53:53Z file_id: '13540' file_name: Fig5_a_3.tif file_size: 15812494 relation: main_file success: 1 - access_level: open_access checksum: 7c34b19a1764e2f501f11dcabd442ce2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:53Z date_updated: 2023-08-03T11:53:53Z file_id: '13541' file_name: Fig5_a_4.tif file_size: 11117689 relation: main_file success: 1 - access_level: open_access checksum: c49af4b96532e00b3a51574a2a94decb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:53Z date_updated: 2023-08-03T11:53:53Z file_id: '13542' file_name: Fig5_a_5.tif file_size: 111665 relation: main_file success: 1 - access_level: open_access checksum: 1b42eadcdd71f2dc00d82784673aa577 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:54Z date_updated: 2023-08-03T11:53:54Z file_id: '13543' file_name: Fig5_b_1.tif file_size: 16676449 relation: main_file success: 1 - access_level: open_access checksum: 0d27266bf216f71fcb5496731ce76dd5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:54Z date_updated: 2023-08-03T11:53:54Z file_id: '13544' file_name: Fig5_b_2-4.tif file_size: 427651 relation: main_file success: 1 - access_level: open_access checksum: c4232930068a0a8f7c8a70ce0ea48dc2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:55Z date_updated: 2023-08-03T11:53:55Z file_id: '13545' file_name: Fig5_c_1-3.tif file_size: 11117705 relation: main_file success: 1 - access_level: open_access checksum: c9caad749be0ef04ef8013cfdb69f8fc content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:55Z date_updated: 2023-08-03T11:53:55Z file_id: '13546' file_name: Fig5_c_2-4.tif file_size: 254153 relation: main_file success: 1 - access_level: open_access checksum: 5c6d36b96bde1e090cc428b269aba6ec content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:54:14Z date_updated: 2023-08-03T11:54:14Z file_id: '13547' file_name: Fig5_e_1.tif file_size: 737290746 relation: main_file success: 1 - access_level: open_access checksum: f97632984b6a73e06cc0c8c947cdcc71 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:57Z date_updated: 2023-08-03T11:53:57Z file_id: '13548' file_name: Fig5_e_2.tif file_size: 31366288 relation: main_file success: 1 - access_level: open_access checksum: 8c471eeaa59008eed9e91afe5e1f1698 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:57Z date_updated: 2023-08-03T11:53:57Z file_id: '13549' file_name: Fig5_e_3.tif file_size: 1216304 relation: main_file success: 1 - access_level: open_access checksum: 31c10c3a1d874b5028e35e2dd8800a68 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:59Z date_updated: 2023-08-03T11:53:59Z file_id: '13550' file_name: Fig5_g.tif file_size: 35669193 relation: main_file success: 1 - access_level: open_access checksum: 0e9fe7b7ee06a630837e9d3c41b80e01 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:53:59Z date_updated: 2023-08-03T11:53:59Z file_id: '13551' file_name: Fig5_h.tif file_size: 7492349 relation: main_file success: 1 - access_level: open_access checksum: d25b3d04bb8364089cafdf8deb6846b6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:18Z date_updated: 2023-08-03T11:59:18Z file_id: '13552' file_name: Fig6_a_1.tif file_size: 121446390 relation: main_file success: 1 - access_level: open_access checksum: 4361e10db6ec48c2d4579ac089ff3ca3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:22Z date_updated: 2023-08-03T11:59:22Z file_id: '13553' file_name: Fig6_a_2.tif file_size: 264412158 relation: main_file success: 1 - access_level: open_access checksum: fe3a00ae75fb3388438e53ced92a9498 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:21Z date_updated: 2023-08-03T11:59:21Z file_id: '13554' file_name: Fig6_a_3.tif file_size: 57399051 relation: main_file success: 1 - access_level: open_access checksum: 4372c13d6dd2274aa749799b8e96bf06 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:21Z date_updated: 2023-08-03T11:59:21Z file_id: '13555' file_name: Fig6_b_left.tif file_size: 6003163 relation: main_file success: 1 - access_level: open_access checksum: f7ae4e50f2f4d414c598bddd691b722a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:21Z date_updated: 2023-08-03T11:59:21Z file_id: '13556' file_name: Fig6_b_right.tif file_size: 511265 relation: main_file success: 1 - access_level: open_access checksum: cde658a9ca666bdef1b29613ab72092d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:39Z date_updated: 2023-08-03T11:59:39Z file_id: '13557' file_name: Fig6_c_n2v.tif file_size: 467125933 relation: main_file success: 1 - access_level: open_access checksum: 57e73c1fedcee4bd8ab62518baa0e0e5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:36Z date_updated: 2023-08-03T11:59:36Z file_id: '13558' file_name: Fig6_c.tif file_size: 322251440 relation: main_file success: 1 - access_level: open_access checksum: 53175073b83ab569241ae64ef7f180b3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:38Z date_updated: 2023-08-03T11:59:38Z file_id: '13559' file_name: Fig6_d_1.tif file_size: 37641738 relation: main_file success: 1 - access_level: open_access checksum: af97423e1077af85465a5e39fa25d1e4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:40Z date_updated: 2023-08-03T11:59:40Z file_id: '13560' file_name: Fig6_d_2.tif file_size: 70596929 relation: main_file success: 1 - access_level: open_access checksum: f1fd7a9fa2a12a930fe35bdf53ba3ff7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:42Z date_updated: 2023-08-03T11:59:42Z file_id: '13561' file_name: Fig6_d_3.tif file_size: 15303146 relation: main_file success: 1 - access_level: open_access checksum: 95655df5cdb05f09912298de9a3711b4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:41Z date_updated: 2023-08-03T11:59:41Z file_id: '13562' file_name: Fig6_d_4.tif file_size: 893051 relation: main_file success: 1 - access_level: open_access checksum: 4d722b4e09ce617252d284f78ea2ee30 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:58Z date_updated: 2023-08-03T11:59:58Z file_id: '13563' file_name: Fig6_e.tif file_size: 381232200 relation: main_file success: 1 - access_level: open_access checksum: d1eda9599f422a614404dd112f0c3185 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T11:59:58Z date_updated: 2023-08-03T11:59:58Z file_id: '13564' file_name: Fig6_f.tif file_size: 345804470 relation: main_file success: 1 - access_level: open_access checksum: 1cd202570f964b78e1f55c987d5d5de1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:00:08Z date_updated: 2023-08-03T12:00:08Z file_id: '13565' file_name: Fig6_g.tif file_size: 346119927 relation: main_file success: 1 - access_level: open_access checksum: 78cbf1906ff8746ed524c62f8f580f52 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:00:02Z date_updated: 2023-08-03T12:00:02Z file_id: '13566' file_name: Fig6_h.tif file_size: 7064977 relation: main_file success: 1 - access_level: open_access checksum: 21635ce59f1ae5a334aaad3f4c0b171c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:00:03Z date_updated: 2023-08-03T12:00:03Z file_id: '13567' file_name: Fig6_i.tif file_size: 7110129 relation: main_file success: 1 - access_level: open_access checksum: 704962856f2a024ce1f321a1785556e3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:00:07Z date_updated: 2023-08-03T12:00:07Z file_id: '13568' file_name: Fig6_j.tif file_size: 110297540 relation: main_file success: 1 - access_level: open_access checksum: 4b74ba5ae1e2bb2201bf51c74d733268 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:00:07Z date_updated: 2023-08-03T12:00:07Z file_id: '13569' file_name: Fig6_k.tif file_size: 11117689 relation: main_file success: 1 - access_level: open_access checksum: a8efa3007df4e9e0f80c7a2bbc451178 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13570' file_name: Extdata_01_a_1.tif file_size: 1287107 relation: main_file success: 1 - access_level: open_access checksum: 7f24b6c84ce96a67347eb5ef4c43fac1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13571' file_name: Extdata_01_a_2.tif file_size: 58307 relation: main_file success: 1 - access_level: open_access checksum: fa7ae4eefc11b9b60c4ab80f6e839b73 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13572' file_name: Extdata_01_a_3.tif file_size: 1283209 relation: main_file success: 1 - access_level: open_access checksum: cec9a5eb87f1b56e64626a00c6d0e53d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13573' file_name: Extdata_01_a_4.tif file_size: 54409 relation: main_file success: 1 - access_level: open_access checksum: 450e4786d66d5059028420153908a4dc content_type: image/png creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13574' file_name: Extdata_01_c_1.png file_size: 2431 relation: main_file success: 1 - access_level: open_access checksum: feb758609b399cf644dd3ae7cd75fb96 content_type: image/png creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13575' file_name: Extdata_01_c_2.png file_size: 612 relation: main_file success: 1 - access_level: open_access checksum: 52f43300a50f83f9a6ff1409324086ee content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13576' file_name: Extdata_01_d_1.tif file_size: 433981 relation: main_file success: 1 - access_level: open_access checksum: 28925dcf8792f524e286beb16b0c532c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13577' file_name: Extdata_01_d_2.tif file_size: 19649 relation: main_file success: 1 - access_level: open_access checksum: c93b2f0426c80d18e252435f1e146568 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13578' file_name: Extdata_01_d_3.tif file_size: 433981 relation: main_file success: 1 - access_level: open_access checksum: c0ed722a768001431f47646ef98c44da content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13579' file_name: Extdata_01_d_4.tif file_size: 19649 relation: main_file success: 1 - access_level: open_access checksum: db9d386276b985b8e702f797e910bd0b content_type: image/png creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13580' file_name: Extdata_01_f_1.png file_size: 4752 relation: main_file success: 1 - access_level: open_access checksum: 244f6645d191c50d997c0dc6a15535ec content_type: image/png creator: jdanzl date_created: 2023-08-03T12:05:41Z date_updated: 2023-08-03T12:05:41Z file_id: '13581' file_name: Extdata_01_f_2.png file_size: 2698 relation: main_file success: 1 - access_level: open_access checksum: 3d6100b836d850b38e66e0f5a7919495 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:07:27Z date_updated: 2023-08-03T12:07:27Z file_id: '13582' file_name: Extdata_02_a.tif file_size: 24003247 relation: main_file success: 1 - access_level: open_access checksum: 3cd6a3b7bf2061cf5c7810c0001236e5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:07:27Z date_updated: 2023-08-03T12:07:27Z file_id: '13583' file_name: Extdata_02_b.tif file_size: 1164723 relation: main_file success: 1 - access_level: open_access checksum: d87c82d663ffea379cc86c56981e2e16 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:10:32Z date_updated: 2023-08-03T12:10:32Z file_id: '13584' file_name: Extdata_03_SYPH1_xy_1.tif file_size: 7109763 relation: main_file success: 1 - access_level: open_access checksum: a3703d0d26393578d4ba466681fc6be8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:10:32Z date_updated: 2023-08-03T12:10:32Z file_id: '13585' file_name: Extdata_03_SYPH1_xz_1-2.tif file_size: 27791 relation: main_file success: 1 - access_level: open_access checksum: f653ac7d531cf9896cbd6a9edf2a7759 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:10:32Z date_updated: 2023-08-03T12:10:32Z file_id: '13586' file_name: Extdata_03_SYPH1_xz_3-4.tif file_size: 27721 relation: main_file success: 1 - access_level: open_access checksum: 04edbb337df4d5470e033a4f53c07300 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:10:33Z date_updated: 2023-08-03T12:10:33Z file_id: '13587' file_name: Extdata_03_SYPH1_xz_n2v.tif file_size: 57657482 relation: main_file success: 1 - access_level: open_access checksum: 09e1fe2dd3a1e8349693fda55d0985ca content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:10:34Z date_updated: 2023-08-03T12:10:34Z file_id: '13588' file_name: Extdata_03_SYPH1_xz.tif file_size: 57657527 relation: main_file success: 1 - access_level: open_access checksum: 458f8d486cb63876c6664cde4a9be27c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:25Z date_updated: 2023-08-03T12:12:25Z file_id: '13589' file_name: Extdata_03_SYP1_xy_1.tif file_size: 7109763 relation: main_file success: 1 - access_level: open_access checksum: e2dfccc882d85b660d65a596e1a8cbac content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:25Z date_updated: 2023-08-03T12:12:25Z file_id: '13590' file_name: Extdata_03_SYP1_xy_2-3.tif file_size: 72963 relation: main_file success: 1 - access_level: open_access checksum: a331be6052c68cc027cdb79f15447d9a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:25Z date_updated: 2023-08-03T12:12:25Z file_id: '13591' file_name: Extdata_03_SYP1_xz_1-2.tif file_size: 27724 relation: main_file success: 1 - access_level: open_access checksum: 4de626b035b43feaacd923fca411e6a2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:25Z date_updated: 2023-08-03T12:12:25Z file_id: '13592' file_name: Extdata_03_SYP1_xz_3-4.tif file_size: 27724 relation: main_file success: 1 - access_level: open_access checksum: d8076e927a074f024924d9bdb6fdd5e6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:30Z date_updated: 2023-08-03T12:12:30Z file_id: '13593' file_name: Extdata_03_SYP1_xz_n2v.tif file_size: 214613644 relation: main_file success: 1 - access_level: open_access checksum: 79cf7d0f450c397caa877dd06b52f8df content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:12:30Z date_updated: 2023-08-03T12:12:30Z file_id: '13594' file_name: Extdata_03_SYP1_xz.tif file_size: 214613687 relation: main_file success: 1 - access_level: open_access checksum: 60ac6ea988d9b8bdaba2f09e0e1ef370 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:29Z date_updated: 2023-08-03T12:14:29Z file_id: '13595' file_name: Extdata03_VAMP2_xy_1.tif file_size: 7109747 relation: main_file success: 1 - access_level: open_access checksum: 92bf312da2dd356aa4fc9a0e7d811af2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:29Z date_updated: 2023-08-03T12:14:29Z file_id: '13596' file_name: Extdata03_VAMP2_xy_2-3.tif file_size: 72947 relation: main_file success: 1 - access_level: open_access checksum: 9319e293092eeee24e3c658fc178af1a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:29Z date_updated: 2023-08-03T12:14:29Z file_id: '13597' file_name: Extdata03_VAMP2_xz_1-2.tif file_size: 27724 relation: main_file success: 1 - access_level: open_access checksum: a627d7fd9a89bdde968e6d9bff846254 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:29Z date_updated: 2023-08-03T12:14:29Z file_id: '13598' file_name: Extdata03_VAMP2_xz_3-4.tif file_size: 27708 relation: main_file success: 1 - access_level: open_access checksum: 7a5363a185edce59ce57535f7d855092 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:32Z date_updated: 2023-08-03T12:14:32Z file_id: '13599' file_name: Extdata03_VAMP2_xz_n2v.tif file_size: 102457485 relation: main_file success: 1 - access_level: open_access checksum: 8e7fc4d00fff8ec6d9340e969f37e176 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:14:32Z date_updated: 2023-08-03T12:14:32Z file_id: '13600' file_name: Extdata03_VAMP2_xz.tif file_size: 102457527 relation: main_file success: 1 - access_level: open_access checksum: be17472f73ed8cd02a700b861f1dbac0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:08Z date_updated: 2023-08-03T12:16:08Z file_id: '13601' file_name: Extdata04_VGLUT_xy_1.tif file_size: 11117763 relation: main_file success: 1 - access_level: open_access checksum: dbc3ec477f491ce3e98ab40475bd90ca content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:08Z date_updated: 2023-08-03T12:16:08Z file_id: '13602' file_name: Extdata04_VGLUT_xy_2-3.tif file_size: 72947 relation: main_file success: 1 - access_level: open_access checksum: 8ee877e6b843bb0e38febb0481962d69 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:08Z date_updated: 2023-08-03T12:16:08Z file_id: '13603' file_name: Extdata04_VGLUT_xz_1-2.tif file_size: 53367 relation: main_file success: 1 - access_level: open_access checksum: 9873f54d50955a2c204d0559c87aa13d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:08Z date_updated: 2023-08-03T12:16:08Z file_id: '13604' file_name: Extdata04_VGLUT_xz_3-4.tif file_size: 53358 relation: main_file success: 1 - access_level: open_access checksum: 8eda08ae5981fcfa3758d0320b1923af content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:11Z date_updated: 2023-08-03T12:16:11Z file_id: '13605' file_name: Extdata04_VGLUT_xz_n2v.tif file_size: 144076208 relation: main_file success: 1 - access_level: open_access checksum: bc0b10229d498f60996a5b05cb87c428 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:16:10Z date_updated: 2023-08-03T12:16:10Z file_id: '13606' file_name: Extdata04_VGLUT_xz.tif file_size: 72071440 relation: main_file success: 1 - access_level: open_access checksum: e8d093ce7d98ea5647d8a80e3084c40b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:32Z date_updated: 2023-08-03T12:32:32Z file_id: '13607' file_name: Extdata03_VGAT_xy_1.tif file_size: 7109763 relation: main_file success: 1 - access_level: open_access checksum: 36590ca7a586de7ad76d3ad659c38995 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:32Z date_updated: 2023-08-03T12:32:32Z file_id: '13608' file_name: Extdata03_VGAT_xy_2-3.tif file_size: 72947 relation: main_file success: 1 - access_level: open_access checksum: 3914c7709f69d4d18f23a9fb6dc64572 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:32Z date_updated: 2023-08-03T12:32:32Z file_id: '13609' file_name: Extdata03_VGAT_xz_1-2.tif file_size: 53355 relation: main_file success: 1 - access_level: open_access checksum: fa98aa521adaefb9e4476fe519e88e59 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:32Z date_updated: 2023-08-03T12:32:32Z file_id: '13610' file_name: Extdata03_VGAT_xz_3-4.tif file_size: 53339 relation: main_file success: 1 - access_level: open_access checksum: cd6f384c51756977e37f45043c913252 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:36Z date_updated: 2023-08-03T12:32:36Z file_id: '13611' file_name: Extdata03_VGAT_xz_n2v.tif file_size: 204861338 relation: main_file success: 1 - access_level: open_access checksum: fb7e46feda5ac07877a91ad963da0e31 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:32:35Z date_updated: 2023-08-03T12:32:35Z file_id: '13612' file_name: Extdata03_VGAT_xz.tif file_size: 102457527 relation: main_file success: 1 - access_level: open_access checksum: fe033e0a377d391cd8e4af04987d9900 content_type: image/png creator: jdanzl date_created: 2023-08-03T12:36:46Z date_updated: 2023-08-03T12:36:46Z file_id: '13613' file_name: Extdata04_MUNC_xy_1.png file_size: 4348932 relation: main_file success: 1 - access_level: open_access checksum: 771d8e2b9192b6620f54ab30e4fad594 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:35:58Z date_updated: 2023-08-03T12:35:58Z file_id: '13614' file_name: Extdata04_MUNC_xy_2-3.tif file_size: 72947 relation: main_file success: 1 - access_level: open_access checksum: 4256d8f06fa2077b352776cf76b46618 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:35:58Z date_updated: 2023-08-03T12:35:58Z file_id: '13615' file_name: Extdata04_MUNC_xz_1-2.tif file_size: 53435 relation: main_file success: 1 - access_level: open_access checksum: 0b9365638c81d545e773170cf04b04b8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:35:58Z date_updated: 2023-08-03T12:35:58Z file_id: '13616' file_name: Extdata04_MUNC_xz_3-4.tif file_size: 55941 relation: main_file success: 1 - access_level: open_access checksum: 9fa62688dab03c592cec47bf5d1c304d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:36:04Z date_updated: 2023-08-03T12:36:04Z file_id: '13617' file_name: Extdata04_MUNC_xz_n2v.tif file_size: 204861404 relation: main_file success: 1 - access_level: open_access checksum: 39f710080a26136dbbe4c8916b434c65 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:36:02Z date_updated: 2023-08-03T12:36:02Z file_id: '13618' file_name: Extdata04_MUNC_xz.tif file_size: 102457527 relation: main_file success: 1 - access_level: open_access checksum: eaabc8112645a73f4326e621b4e6ad0a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:39Z date_updated: 2023-08-03T12:38:39Z file_id: '13619' file_name: Extdata04_BASSOON_xy_1.tif file_size: 11117757 relation: main_file success: 1 - access_level: open_access checksum: 15f624d29c473ce6e0ae7e466efc059a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:39Z date_updated: 2023-08-03T12:38:39Z file_id: '13620' file_name: Extdata04_BASSOON_xy_2-3.tif file_size: 74041 relation: main_file success: 1 - access_level: open_access checksum: 1cb4b4d219767a30072c804a07140240 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:39Z date_updated: 2023-08-03T12:38:39Z file_id: '13621' file_name: Extdata04_BASSOON_xz_1-2.tif file_size: 53435 relation: main_file success: 1 - access_level: open_access checksum: 1bac9c192da9375d81cb3747f48c9be4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:39Z date_updated: 2023-08-03T12:38:39Z file_id: '13622' file_name: Extdata04_BASSOON_xz_3-4.tif file_size: 53362 relation: main_file success: 1 - access_level: open_access checksum: 57fa91bfb1e2937e3449e57096b6fc74 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:50Z date_updated: 2023-08-03T12:38:50Z file_id: '13623' file_name: Extdata04_BASSOON_xz_n2v.tif file_size: 576071410 relation: main_file success: 1 - access_level: open_access checksum: ac51a734dcf7d1b94afcd4a471f10626 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:38:46Z date_updated: 2023-08-03T12:38:46Z file_id: '13624' file_name: Extdata04_BASSOON_xz.tif file_size: 288066640 relation: main_file success: 1 - access_level: open_access checksum: 244043f7acba250d560e29123702dcd7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:40:57Z date_updated: 2023-08-03T12:40:57Z file_id: '13625' file_name: Extdata04_HOMER1_xy_1.tif file_size: 7109763 relation: main_file success: 1 - access_level: open_access checksum: eff51ff97539f6491989bfc3d3f88860 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:40:57Z date_updated: 2023-08-03T12:40:57Z file_id: '13626' file_name: Extdata04_HOMER1_xy_2-3.tif file_size: 72963 relation: main_file success: 1 - access_level: open_access checksum: df35046d9bca4e97a5625c5a55218cfb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:40:57Z date_updated: 2023-08-03T12:40:57Z file_id: '13627' file_name: Extdata04_HOMER1_xz_1-2.tif file_size: 53375 relation: main_file success: 1 - access_level: open_access checksum: 5dc7536f7aaea084dfc329537d8412ce content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:40:57Z date_updated: 2023-08-03T12:40:57Z file_id: '13628' file_name: Extdata04_HOMER1_xz_3-4.tif file_size: 53359 relation: main_file success: 1 - access_level: open_access checksum: 0b407669a26b9d7730a41361ceffda9a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:41:00Z date_updated: 2023-08-03T12:41:00Z file_id: '13629' file_name: Extdata04_HOMER1_xz_n2v.tif file_size: 204861339 relation: main_file success: 1 - access_level: open_access checksum: f95a0da9bea8b605fc2ed310190836b3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:40:59Z date_updated: 2023-08-03T12:40:59Z file_id: '13630' file_name: Extdata04_HOMER1_xz.tif file_size: 102457527 relation: main_file success: 1 - access_level: open_access checksum: cf74307696548e7aa90e59a0935a74a1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:08Z date_updated: 2023-08-03T12:45:08Z file_id: '13631' file_name: Extdata04_SHANK2_xy_1.tif file_size: 7120361 relation: main_file success: 1 - access_level: open_access checksum: 7b3490246df4f5bb68d0df682161820f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:08Z date_updated: 2023-08-03T12:45:08Z file_id: '13632' file_name: Extdata04_SHANK2_xy_2-3.tif file_size: 72973 relation: main_file success: 1 - access_level: open_access checksum: c599d6830e61c386219e266f4717fe7c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:08Z date_updated: 2023-08-03T12:45:08Z file_id: '13633' file_name: Extdata04_SHANK2_xz_1-2.tif file_size: 53443 relation: main_file success: 1 - access_level: open_access checksum: 5b9912b2a408d224ad669f39dc8d5bc6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:08Z date_updated: 2023-08-03T12:45:08Z file_id: '13634' file_name: Extdata04_SHANK2_xz_3-4.tif file_size: 53362 relation: main_file success: 1 - access_level: open_access checksum: 17f2064ceeb99cbb51208c27b1961ed5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:30Z date_updated: 2023-08-03T12:45:30Z file_id: '13635' file_name: Extdata04_SHANK2_xz_n2v.tif file_size: 691291157 relation: main_file success: 1 - access_level: open_access checksum: 21f1bb8d2a00c88bdd6febe6285acc2a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:45:26Z date_updated: 2023-08-03T12:45:26Z file_id: '13636' file_name: Extdata04_SHANK2_xz.tif file_size: 518519275 relation: main_file success: 1 - access_level: open_access checksum: 47597ca873f1ea81cd4f7e9bfbb34aa4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:25Z date_updated: 2023-08-03T12:46:25Z file_id: '13637' file_name: Extdata04_GEPHYRIN_xy_1.tif file_size: 752109 relation: main_file success: 1 - access_level: open_access checksum: 14ed7ae64eb783e6b30f824f21959d0f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:25Z date_updated: 2023-08-03T12:46:25Z file_id: '13638' file_name: Extdata04_GEPHYRIN_xy_2-3.tif file_size: 72909 relation: main_file success: 1 - access_level: open_access checksum: e361e226428d7b23618eed35b1cad080 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:25Z date_updated: 2023-08-03T12:46:25Z file_id: '13639' file_name: Extdata04_GEPHYRIN_xz_1-2.tif file_size: 53375 relation: main_file success: 1 - access_level: open_access checksum: abe7cee22f69fc2bf1a3ff9955ccf45a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:25Z date_updated: 2023-08-03T12:46:25Z file_id: '13640' file_name: Extdata04_GEPHYRIN_xz_3-4.tif file_size: 53360 relation: main_file success: 1 - access_level: open_access checksum: 59b49b451a63c5ac06fa31a17640c1a2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:27Z date_updated: 2023-08-03T12:46:27Z file_id: '13641' file_name: Extdata04_GEPHYRIN_xz_n2v.tif file_size: 73174939 relation: main_file success: 1 - access_level: open_access checksum: 1ee1feea85c8319ebc6c49147502e412 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:46:26Z date_updated: 2023-08-03T12:46:26Z file_id: '13642' file_name: Extdata04_GEPHYRIN_xz.tif file_size: 36614327 relation: main_file success: 1 - access_level: open_access checksum: 64d9d868ef89c5cfc65cb199aff831b4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:52:23Z date_updated: 2023-08-03T12:52:23Z file_id: '13643' file_name: Extdata06_a-b_n2v.tif file_size: 2195652677 relation: main_file success: 1 - access_level: open_access checksum: df41d97987798715b1f66e6e72be169b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:51:41Z date_updated: 2023-08-03T12:51:41Z file_id: '13644' file_name: Extdata06_a-b.tif file_size: 1097875840 relation: main_file success: 1 - access_level: open_access checksum: 95a3eaa3b70e964f6871a5765a53659b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:52:57Z date_updated: 2023-08-03T12:52:57Z file_id: '13645' file_name: Extdata07_01_bottom.tif file_size: 3564577 relation: main_file success: 1 - access_level: open_access checksum: 80b41ad0de73fd61eb67a35262627fac content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:52:57Z date_updated: 2023-08-03T12:52:57Z file_id: '13646' file_name: Extdata07_01_top.tif file_size: 11958844 relation: main_file success: 1 - access_level: open_access checksum: f694a0f11e2f782702cb4c411941873a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13647' file_name: Extdata07_2_bottom.tif file_size: 3564581 relation: main_file success: 1 - access_level: open_access checksum: b8b1a1339a25806615c0aa7906a032ff content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13648' file_name: Extdata07_2_top.tif file_size: 11973592 relation: main_file success: 1 - access_level: open_access checksum: 8a24eb623d65d809fe8afbd527528a77 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13649' file_name: Extdata07_3_bottom.tif file_size: 1281901 relation: main_file success: 1 - access_level: open_access checksum: 816b35def703bc48d55b0293fcd8212f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13650' file_name: Extdata07_3_top.tif file_size: 16569776 relation: main_file success: 1 - access_level: open_access checksum: 7f1375ab8cf28cd136e2e44d1fdfd87d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13651' file_name: Extdata07_04_bottom.tif file_size: 3564595 relation: main_file success: 1 - access_level: open_access checksum: b1dbda28e2a010968716c0411568f139 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:27Z date_updated: 2023-08-03T12:54:27Z file_id: '13652' file_name: Extdata07_04_top.tif file_size: 5896404 relation: main_file success: 1 - access_level: open_access checksum: d6e96b7c8e6a7084c14eda83a4dd778a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13653' file_name: Extdata07_5_bottom.tif file_size: 3564609 relation: main_file success: 1 - access_level: open_access checksum: a647f89a3048f71512cc58c9e53ec022 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13654' file_name: Extdata07_5_top.tif file_size: 15555618 relation: main_file success: 1 - access_level: open_access checksum: 66becb046fe591914df572617d720202 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13655' file_name: Extdata07_6_bottom.tif file_size: 3564577 relation: main_file success: 1 - access_level: open_access checksum: 5d76b2ad7d7acbb1afa27cf52194b1cb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13656' file_name: Extdata07_6_top.tif file_size: 6038186 relation: main_file success: 1 - access_level: open_access checksum: 7f137bdea0f0acb3db75c983ce44ab44 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13657' file_name: Extdata07_7_bottom.tif file_size: 3560937 relation: main_file success: 1 - access_level: open_access checksum: 479e26106280eb61a2d74e29137a2e43 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13658' file_name: Extdata07_7_top.tif file_size: 12031850 relation: main_file success: 1 - access_level: open_access checksum: 8426197ad283c1bc83e3193f323d5f5a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13659' file_name: Extdata07_8_bottom.tif file_size: 3560937 relation: main_file success: 1 - access_level: open_access checksum: b9f75a82b564e1c5c363a495d078f6b7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13660' file_name: Extdata07_8_top.tif file_size: 22877176 relation: main_file success: 1 - access_level: open_access checksum: 7f1a9f3bb9611362995ae832b2607f4d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13661' file_name: Extdata07_9_bottom.tif file_size: 3564605 relation: main_file success: 1 - access_level: open_access checksum: 40286bcb876b655d7421534d0215e86b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T12:54:28Z date_updated: 2023-08-03T12:54:28Z file_id: '13662' file_name: Extdata07_9_top.tif file_size: 2744190 relation: main_file success: 1 - access_level: open_access checksum: 4af220986cc94d412c2354aa7e6c8cce content_type: image/png creator: jdanzl date_created: 2023-08-03T13:00:03Z date_updated: 2023-08-03T13:00:03Z file_id: '13663' file_name: Extdata08_6_left.png file_size: 7243611 relation: main_file success: 1 - access_level: open_access checksum: af9c2299f1005a3ccc39f41082cea642 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:03Z date_updated: 2023-08-03T13:00:03Z file_id: '13664' file_name: Extdata08_6_right.tif file_size: 5562487 relation: main_file success: 1 - access_level: open_access checksum: 63ef28a174215c70e31d2cabf67d90fc content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:04Z date_updated: 2023-08-03T13:00:04Z file_id: '13665' file_name: Extdata08_7_left.tif file_size: 34745956 relation: main_file success: 1 - access_level: open_access checksum: 46de918dfe5f3c23e497ee3daa608dd9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:03Z date_updated: 2023-08-03T13:00:03Z file_id: '13666' file_name: Extdata08_7_right.tif file_size: 5562483 relation: main_file success: 1 - access_level: open_access checksum: 8243a7985d2902446183adc35519a0c8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:04Z date_updated: 2023-08-03T13:00:04Z file_id: '13667' file_name: Extdata08_b_1_left.tif file_size: 31506150 relation: main_file success: 1 - access_level: open_access checksum: 857cffa31569efcd5917f9802a106d58 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:04Z date_updated: 2023-08-03T13:00:04Z file_id: '13668' file_name: Extdata08_b_1_right.tif file_size: 11117705 relation: main_file success: 1 - access_level: open_access checksum: e34902de9119d2cd9f1910f610627c5f content_type: image/png creator: jdanzl date_created: 2023-08-03T13:00:04Z date_updated: 2023-08-03T13:00:04Z file_id: '13669' file_name: Extdata08_b_2_left.png file_size: 3540493 relation: main_file success: 1 - access_level: open_access checksum: 1247d636ac5af22e8950ffd2ff213fea content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:05Z date_updated: 2023-08-03T13:00:05Z file_id: '13670' file_name: Extdata08_b_2_right.tif file_size: 5562553 relation: main_file success: 1 - access_level: open_access checksum: f47c2d3f6824e08853ae2631f6ee7c5f content_type: image/png creator: jdanzl date_created: 2023-08-03T13:00:05Z date_updated: 2023-08-03T13:00:05Z file_id: '13671' file_name: Extdata08_b_3_left.png file_size: 3541547 relation: main_file success: 1 - access_level: open_access checksum: 1247d636ac5af22e8950ffd2ff213fea content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:05Z date_updated: 2023-08-03T13:00:05Z file_id: '13672' file_name: Extdata08_b_3_right.tif file_size: 5562553 relation: main_file success: 1 - access_level: open_access checksum: e90a95ec902a683678acd70336852fd9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:05Z date_updated: 2023-08-03T13:00:05Z file_id: '13673' file_name: Extdata08_b_4_left.tif file_size: 25819844 relation: main_file success: 1 - access_level: open_access checksum: 94cd44cd1c8c7a87ffd5861bf88561a1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:05Z date_updated: 2023-08-03T13:00:05Z file_id: '13674' file_name: Extdata08_b_4_right.tif file_size: 5561131 relation: main_file success: 1 - access_level: open_access checksum: fd4ca56dc5c48ad4546df22daef04efc content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:06Z date_updated: 2023-08-03T13:00:06Z file_id: '13675' file_name: Extdata08_b_5_left.tif file_size: 38786287 relation: main_file success: 1 - access_level: open_access checksum: 52c04890160c4e0f23d3fe2d3ed0c8e7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:00:06Z date_updated: 2023-08-03T13:00:06Z file_id: '13676' file_name: Extdata08_b_5_right.tif file_size: 5562487 relation: main_file success: 1 - access_level: open_access checksum: 47ee6f4b083130d5bb720bcf8a832443 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:52Z date_updated: 2023-08-03T13:04:52Z file_id: '13677' file_name: Extdata08_a_1-1.png file_size: 2133527 relation: main_file success: 1 - access_level: open_access checksum: 5ca2279c372b3b7dbce3ea5658a68399 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:52Z date_updated: 2023-08-03T13:04:52Z file_id: '13678' file_name: Extdata08_a_1-2.png file_size: 1782607 relation: main_file success: 1 - access_level: open_access checksum: 34b7781e3e4abf9f30a0c85db156b6d5 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:52Z date_updated: 2023-08-03T13:04:52Z file_id: '13679' file_name: Extdata08_a_2.png file_size: 5117469 relation: main_file success: 1 - access_level: open_access checksum: 25717007393682098d2208bd0676a0f7 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:52Z date_updated: 2023-08-03T13:04:52Z file_id: '13680' file_name: Extdata08_a_3.png file_size: 6911658 relation: main_file success: 1 - access_level: open_access checksum: b4b003809acec33c71628066744c7ea9 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:53Z date_updated: 2023-08-03T13:04:53Z file_id: '13681' file_name: Extdata08_a_4.png file_size: 8579427 relation: main_file success: 1 - access_level: open_access checksum: 4410976cf867ecacf8f197dbd28cc5a0 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:53Z date_updated: 2023-08-03T13:04:53Z file_id: '13682' file_name: Extdata08_a_5.png file_size: 9675065 relation: main_file success: 1 - access_level: open_access checksum: a235dd204f28d3323883e044b031b984 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:53Z date_updated: 2023-08-03T13:04:53Z file_id: '13683' file_name: Extdata08_a_6.png file_size: 9769588 relation: main_file success: 1 - access_level: open_access checksum: 0e2b768e4eb7200cf6fe28ba511a5ef6 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:53Z date_updated: 2023-08-03T13:04:53Z file_id: '13684' file_name: Extdata08_a_7.png file_size: 9114791 relation: main_file success: 1 - access_level: open_access checksum: df4a01c62233ee8ed601c4b90d7780d0 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:04:57Z date_updated: 2023-08-03T13:04:57Z file_id: '13685' file_name: Extdata08_a_8.png file_size: 124540688 relation: main_file success: 1 - access_level: open_access checksum: 1f407c7915e2717a56fec258708e7b7a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:11:30Z date_updated: 2023-08-03T13:11:30Z file_id: '13686' file_name: Exdata09_c_n2v.tif file_size: 204861336 relation: main_file success: 1 - access_level: open_access checksum: 9089dc7c9914edf9750eebd65819708d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:11:26Z date_updated: 2023-08-03T13:11:26Z file_id: '13687' file_name: Extdata09_a_zoom.tif file_size: 252149 relation: main_file success: 1 - access_level: open_access checksum: 62d295a62cb8dd36c268b28cf0251322 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:11:26Z date_updated: 2023-08-03T13:11:26Z file_id: '13688' file_name: Extdata09_a.tif file_size: 11117705 relation: main_file success: 1 - access_level: open_access checksum: e874d8ee287f924c1076134b5b06bdb2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:11:31Z date_updated: 2023-08-03T13:11:31Z file_id: '13689' file_name: Extdata09_b_n2v.tif file_size: 256074660 relation: main_file success: 1 - access_level: open_access checksum: 488068fff7b42bcf5728739e2a06d742 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:12:53Z date_updated: 2023-08-03T13:12:53Z file_id: '13690' file_name: Extdata10_n2v_CLAHE.tif file_size: 127914854 relation: main_file success: 1 - access_level: open_access checksum: 35351f5af21ce854d41577813a7bdb57 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13691' file_name: Supplfig01_a_1.png file_size: 430878 relation: main_file success: 1 - access_level: open_access checksum: 36204e9e604206366ffc6f61ec91915b content_type: image/png creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13692' file_name: Supplfig01_a_2.png file_size: 438843 relation: main_file success: 1 - access_level: open_access checksum: 92ccc934c4603b29f4f7a96573e49c83 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13693' file_name: Supplfig01_a_3.png file_size: 426713 relation: main_file success: 1 - access_level: open_access checksum: e71faa54934bee8ac3e66ce692f542ab content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13694' file_name: Supplfig01_a_4.tif file_size: 723221 relation: main_file success: 1 - access_level: open_access checksum: 95dc33563f48b650e5ac020bdfd10c48 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13695' file_name: Supplfig01_a_5.tif file_size: 723235 relation: main_file success: 1 - access_level: open_access checksum: c62df0a9faf1c47af121d77eb1582edd content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13696' file_name: Supplfig01_b_1.tif file_size: 1442129 relation: main_file success: 1 - access_level: open_access checksum: 8ae157c5a4a543da1193cb8ca12b1919 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13697' file_name: Supplfig01_b_2.tif file_size: 725407 relation: main_file success: 1 - access_level: open_access checksum: 388370d954ce842781c0d62edfb448a7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13698' file_name: Supplfig01_c_1.tif file_size: 721641 relation: main_file success: 1 - access_level: open_access checksum: 6cae58ba3c98bc8253e1c769e93657a7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13699' file_name: Supplfig01_c_2.tif file_size: 6003079 relation: main_file success: 1 - access_level: open_access checksum: 85cf013232c72895aefc07f5411a765a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13700' file_name: Supplfig01_c_3.tif file_size: 2003311 relation: main_file success: 1 - access_level: open_access checksum: dfb33b91066e3f34d3803f59a4105aba content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13701' file_name: Supplfig01_c_4.tif file_size: 723271 relation: main_file success: 1 - access_level: open_access checksum: 8b899826fe48d7e7536b0b02a2645e87 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13702' file_name: Supplfig01_d_1.tif file_size: 721901 relation: main_file success: 1 - access_level: open_access checksum: 67529fa6e0f12c272275e823f6045f6d content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13703' file_name: Supplfig01_d_2.tif file_size: 721901 relation: main_file success: 1 - access_level: open_access checksum: 111a9231f63c775340d3356109715cb0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13704' file_name: Supplfig01_e_1.tif file_size: 723223 relation: main_file success: 1 - access_level: open_access checksum: 7685bf02408dcb095a00854ff22763ed content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:21:35Z date_updated: 2023-08-03T13:21:35Z file_id: '13705' file_name: Supplfig01_e_2.tif file_size: 723223 relation: main_file success: 1 - access_level: open_access checksum: 455f5cb9aa8a87b91586a27aca122610 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:00Z date_updated: 2023-08-03T13:26:00Z file_id: '13706' file_name: Supplfig02_b_01.tif file_size: 34821298 relation: main_file success: 1 - access_level: open_access checksum: 311545b39aaa2c72755fd8ae190803a5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:00Z date_updated: 2023-08-03T13:26:00Z file_id: '13707' file_name: Supplfig02_b_02.tif file_size: 32131123 relation: main_file success: 1 - access_level: open_access checksum: 682deb61f57d9ca54716160ddd52a6cf content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:01Z date_updated: 2023-08-03T13:26:01Z file_id: '13708' file_name: Supplfig02_b_03.tif file_size: 36872674 relation: main_file success: 1 - access_level: open_access checksum: 4f9579c91b2a3f36ff6e66b592907973 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:01Z date_updated: 2023-08-03T13:26:01Z file_id: '13709' file_name: Supplfig02_b_04.tif file_size: 39964115 relation: main_file success: 1 - access_level: open_access checksum: 7ae7053673b53dbed59ffb92618f969a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:02Z date_updated: 2023-08-03T13:26:02Z file_id: '13710' file_name: Supplfig02_b_05.tif file_size: 43053091 relation: main_file success: 1 - access_level: open_access checksum: 827b26d3d2b6ddc9bced9d6113023ced content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:02Z date_updated: 2023-08-03T13:26:02Z file_id: '13711' file_name: Supplfig02_b_06.tif file_size: 46998147 relation: main_file success: 1 - access_level: open_access checksum: bc2e7e8badb42f8e1facc8b7bc96fdda content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:03Z date_updated: 2023-08-03T13:26:03Z file_id: '13712' file_name: Supplfig02_b_07.tif file_size: 45179219 relation: main_file success: 1 - access_level: open_access checksum: c2b78aa0f433928afa10a743c5fb73b8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:03Z date_updated: 2023-08-03T13:26:03Z file_id: '13713' file_name: Supplfig02_b_08.tif file_size: 46978802 relation: main_file success: 1 - access_level: open_access checksum: 9cd1ab61cced2c0981e813aeae930855 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:04Z date_updated: 2023-08-03T13:26:04Z file_id: '13714' file_name: Supplfig02_b_09.tif file_size: 48840915 relation: main_file success: 1 - access_level: open_access checksum: 3086126338aee6ec4ebc1d3350551197 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:04Z date_updated: 2023-08-03T13:26:04Z file_id: '13715' file_name: Supplfig02_b_10.tif file_size: 45907059 relation: main_file success: 1 - access_level: open_access checksum: 69f52c2b3bb5b5f9fef057860b3386fa content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:05Z date_updated: 2023-08-03T13:26:05Z file_id: '13716' file_name: Supplfig02_b_11.tif file_size: 32231538 relation: main_file success: 1 - access_level: open_access checksum: defdbeab1e672456bfeafdd1983e779e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:26:05Z date_updated: 2023-08-03T13:26:05Z file_id: '13717' file_name: Supplfig02_b_12.tif file_size: 35264963 relation: main_file success: 1 - access_level: open_access checksum: 02c566f781b9ad44f04ce0088a1fa27a content_type: image/png creator: jdanzl date_created: 2023-08-03T13:28:40Z date_updated: 2023-08-03T13:28:40Z file_id: '13718' file_name: Supplfig03_a_std_xy.png file_size: 63326 relation: main_file success: 1 - access_level: open_access checksum: c6c3630ee9a6ed5d207cb68e330da566 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:28:40Z date_updated: 2023-08-03T13:28:40Z file_id: '13719' file_name: Supplfig03_a_std_xz.png file_size: 50211 relation: main_file success: 1 - access_level: open_access checksum: 0dcd4d19e83a7ff259d6aa04d746cd90 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:28:41Z date_updated: 2023-08-03T13:28:41Z file_id: '13720' file_name: Supplfig03_b_std_xy.png file_size: 52629 relation: main_file success: 1 - access_level: open_access checksum: 4785de4a6dcb23b25a06b0da29df5bb5 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:28:41Z date_updated: 2023-08-03T13:28:41Z file_id: '13721' file_name: Supplfig03_b_std_xz.png file_size: 72245 relation: main_file success: 1 - access_level: open_access checksum: 19d0f198bd8a25073e45e7950d7a78c2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:28:45Z date_updated: 2023-08-03T13:28:45Z file_id: '13722' file_name: Supplfig03_model1.tif file_size: 98570368 relation: main_file success: 1 - access_level: open_access checksum: 51ff687df4a0867f39b69c2c7a4ee3ca content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:28:45Z date_updated: 2023-08-03T13:28:45Z file_id: '13723' file_name: Supplfig03_model2.tif file_size: 98570367 relation: main_file success: 1 - access_level: open_access checksum: ec9d9a041ca85fe632c612baf981fcc5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:28:49Z date_updated: 2023-08-03T13:28:49Z file_id: '13724' file_name: Supplfig03_model3.tif file_size: 98570365 relation: main_file success: 1 - access_level: open_access checksum: a988b15a9529094f1b5519a72871e98e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:28:49Z date_updated: 2023-08-03T13:28:49Z file_id: '13725' file_name: Supplfig03_model4.tif file_size: 98570365 relation: main_file success: 1 - access_level: open_access checksum: 4a4fe88fcfd87fcfe118a5a73d81d6b0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:28:52Z date_updated: 2023-08-03T13:28:52Z file_id: '13726' file_name: Supplfig03_model5.tif file_size: 98570369 relation: main_file success: 1 - access_level: open_access checksum: ce9b774ff5163ebfa4e3fb162f4cfffe content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:27Z date_updated: 2023-08-03T13:34:27Z file_id: '13727' file_name: Supplfig04_a_n2v.tif file_size: 1036927887 relation: main_file success: 1 - access_level: open_access checksum: 21f1bb8d2a00c88bdd6febe6285acc2a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:13Z date_updated: 2023-08-03T13:34:13Z file_id: '13728' file_name: Supplfig04_a.tif file_size: 518519275 relation: main_file success: 1 - access_level: open_access checksum: 503820214ab994c01b18a241f3b62434 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:22Z date_updated: 2023-08-03T13:34:22Z file_id: '13729' file_name: Supplfig04_b.tif file_size: 158440069 relation: main_file success: 1 - access_level: open_access checksum: e0469102a87332b46904b4ba35b8fb2f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:37Z date_updated: 2023-08-03T13:34:37Z file_id: '13730' file_name: Supplfig04_c_n2v.tif file_size: 309407894 relation: main_file success: 1 - access_level: open_access checksum: c30a0d18c43045a8fbc5501a37061bd2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:38Z date_updated: 2023-08-03T13:34:38Z file_id: '13731' file_name: Supplfig04_c.tif file_size: 154728887 relation: main_file success: 1 - access_level: open_access checksum: 69c706710d642b30cda6951494702139 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:43Z date_updated: 2023-08-03T13:34:43Z file_id: '13732' file_name: Supplfig04_d_n2v.tif file_size: 106696749 relation: main_file success: 1 - access_level: open_access checksum: 7dbd2e881ebf049352913188fa10224a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:41Z date_updated: 2023-08-03T13:34:41Z file_id: '13733' file_name: Supplfig04_d.tif file_size: 53367343 relation: main_file success: 1 - access_level: open_access checksum: fd0d1ec674dabbb499fab383b7eb4d58 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:46Z date_updated: 2023-08-03T13:34:46Z file_id: '13734' file_name: Supplfig04_e_n2v.tiff file_size: 127917734 relation: main_file success: 1 - access_level: open_access checksum: 86de309d9cd434afbe371da283d8adb6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:34:46Z date_updated: 2023-08-03T13:34:46Z file_id: '13735' file_name: Supplfig04_e.tif file_size: 63974204 relation: main_file success: 1 - access_level: open_access checksum: ada99b2b5900cb198d1de3cc9e37ebd1 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13736' file_name: Supplfig05_a_xy_1.png file_size: 8403 relation: main_file success: 1 - access_level: open_access checksum: f2e382925a972b98560614016ae3bc55 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13737' file_name: Supplfig05_a_xy_2.png file_size: 10087 relation: main_file success: 1 - access_level: open_access checksum: ef22b640f33d677add1a7b5153f95420 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13738' file_name: Supplfig05_a_xy_3.png file_size: 24561 relation: main_file success: 1 - access_level: open_access checksum: b854cc4a5224b8a6f5d59c74f5740ccd content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13739' file_name: Supplfig05_a_xy_4.png file_size: 8353 relation: main_file success: 1 - access_level: open_access checksum: 446b0362c5ea6e2a5f0e1f8359422358 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13740' file_name: Supplfig05_a_xy_5.png file_size: 8337 relation: main_file success: 1 - access_level: open_access checksum: 5585f7b62fa09ed5a63090b679383601 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13741' file_name: Supplfig05_a_xz_1.png file_size: 7399 relation: main_file success: 1 - access_level: open_access checksum: 190d88bcacbd11d41f4a0e2bbd140862 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13742' file_name: Supplfig05_a_xz_2.png file_size: 10887 relation: main_file success: 1 - access_level: open_access checksum: 0c89010651862f21032a303e159b7a1c content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13743' file_name: Supplfig05_a_xz_3.png file_size: 21654 relation: main_file success: 1 - access_level: open_access checksum: 94e61e553aa2280721acce7d407ff24a content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13744' file_name: Supplfig05_a_xz_4.png file_size: 7248 relation: main_file success: 1 - access_level: open_access checksum: ef9157274686ff5d7056f5a519d413dd content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13745' file_name: Supplfig05_a_xz_5.png file_size: 7214 relation: main_file success: 1 - access_level: open_access checksum: 4b389473cbf769e6e34670dae2224af1 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13746' file_name: Supplfig05_b_xy_1.png file_size: 8544 relation: main_file success: 1 - access_level: open_access checksum: b05aa1e201758a5d55e35d719452fafc content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13747' file_name: Supplfig05_b_xy_2.png file_size: 11135 relation: main_file success: 1 - access_level: open_access checksum: 890f3516930251a367066c049141d6bb content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13748' file_name: Supplfig05_b_xy_3.png file_size: 26762 relation: main_file success: 1 - access_level: open_access checksum: 36345c1d582758ff463072fd04578c0c content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13749' file_name: Supplfig05_b_xy_4.png file_size: 8438 relation: main_file success: 1 - access_level: open_access checksum: c9499ad8914c405a07fc4469b19e8987 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13750' file_name: Supplfig05_b_xy_5.png file_size: 8434 relation: main_file success: 1 - access_level: open_access checksum: 7e7a7c900ce1fc3187ab648f207f9425 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13751' file_name: Supplfig05_b_xz_1.png file_size: 8269 relation: main_file success: 1 - access_level: open_access checksum: b645d1e2422ef3f05344ccd3f955468d content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13752' file_name: Supplfig05_b_xz_2.png file_size: 12762 relation: main_file success: 1 - access_level: open_access checksum: ef0b83b49cf47ca7d8ffe3bdc609fe38 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13753' file_name: Supplfig05_b_xz_3.png file_size: 24819 relation: main_file success: 1 - access_level: open_access checksum: 68719d4d464a2ffc198cb6ad070c4579 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:37Z date_updated: 2023-08-03T13:35:37Z file_id: '13754' file_name: Supplfig05_b_xz_4.png file_size: 8126 relation: main_file success: 1 - access_level: open_access checksum: 18370f47177ef37a477c6fd7bda3fea0 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13755' file_name: Supplfig05_b_xz_5.png file_size: 8114 relation: main_file success: 1 - access_level: open_access checksum: 013d4bd9704ace490810b9ef21b12454 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13756' file_name: Supplfig05_c_xy_1.png file_size: 8273 relation: main_file success: 1 - access_level: open_access checksum: bb431f827386e79c54452d6284f501b9 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13757' file_name: Supplfig05_c_xy_2.png file_size: 12639 relation: main_file success: 1 - access_level: open_access checksum: 4cd54f58c5afff88832a508655f913bb content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13758' file_name: Supplfig05_c_xy_3.png file_size: 25288 relation: main_file success: 1 - access_level: open_access checksum: 07f86f98f6a65eac8608cec8c567309e content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13759' file_name: Supplfig05_c_xz_1.png file_size: 6786 relation: main_file success: 1 - access_level: open_access checksum: 492f699b71761214272b17432e3a54fa content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13760' file_name: Supplfig05_c_xz_2.png file_size: 9781 relation: main_file success: 1 - access_level: open_access checksum: af617da5638db849bea6ff51a08227c6 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13761' file_name: Supplfig05_c_xz_3.png file_size: 20728 relation: main_file success: 1 - access_level: open_access checksum: 5e5d5694af4a22297046d697a01fa4d6 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13762' file_name: Supplfig05_d_xy_1.png file_size: 8428 relation: main_file success: 1 - access_level: open_access checksum: 38bf7b75f3dedd0a3722faae05aa0233 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13763' file_name: Supplfig05_d_xy_2.png file_size: 10813 relation: main_file success: 1 - access_level: open_access checksum: e4ea966553f158ec2cfbdc696780390e content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13764' file_name: Supplfig05_d_xy_3.png file_size: 26552 relation: main_file success: 1 - access_level: open_access checksum: 356f424d9f5f608e9aea962bb63672f1 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13765' file_name: Supplfig05_d_xz_1.png file_size: 7876 relation: main_file success: 1 - access_level: open_access checksum: 05068476beee0f394e28b98209686394 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13766' file_name: Supplfig05_d_xz_2.png file_size: 11634 relation: main_file success: 1 - access_level: open_access checksum: 78b3a0d93df22383a384a2f3acc80401 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13767' file_name: Supplfig05_d_xz_3.png file_size: 25006 relation: main_file success: 1 - access_level: open_access checksum: f5ee6a817f11a42c9db82ad6325f58b9 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13768' file_name: Supplfig05_e_xy_1.png file_size: 7895 relation: main_file success: 1 - access_level: open_access checksum: 019ca89e892d6e19589609bc99eab331 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13769' file_name: Supplfig05_e_xy_2.png file_size: 6180 relation: main_file success: 1 - access_level: open_access checksum: 0e1a5cbbd70dc245edaecaca70d974cb content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13770' file_name: Supplfig05_e_xy_3.png file_size: 18326 relation: main_file success: 1 - access_level: open_access checksum: 4d4d64a5bb7b096aaf8130ece4512bc2 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13771' file_name: Supplfig05_e_xz_1.png file_size: 6295 relation: main_file success: 1 - access_level: open_access checksum: 607302aec5ec2a14a271dbffd3465261 content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13772' file_name: Supplfig05_e_xz_2.png file_size: 4335 relation: main_file success: 1 - access_level: open_access checksum: a673e17ead1fd2e776b9a5f560a289ab content_type: image/png creator: jdanzl date_created: 2023-08-03T13:35:38Z date_updated: 2023-08-03T13:35:38Z file_id: '13773' file_name: Supplfig05_e_xz_3.png file_size: 23243 relation: main_file success: 1 - access_level: open_access checksum: 4349e511fc86a8bddb790a7be7175c75 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13774' file_name: Supplfig06_a_1.tif file_size: 4002153 relation: main_file success: 1 - access_level: open_access checksum: cd12977e4c1a472d80193be01f69a895 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13775' file_name: Supplfig06_a_2.tif file_size: 2252137 relation: main_file success: 1 - access_level: open_access checksum: 575e32b8c25ce658e20f0c86a5f1b9b7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13776' file_name: Supplfig06_a_3.tif file_size: 2252137 relation: main_file success: 1 - access_level: open_access checksum: b06f775e0210e7a16cb4b58aed32118c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13777' file_name: Supplfig06_a_i.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: 56854c1a05c721c36877fe7c7454b7d7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13778' file_name: Supplfig06_a_ii.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: 9aff42ea5138931fedb5a00643ae7a22 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13779' file_name: Supplfig06_a_iii.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: 9474b7d00d4dee46659afedef75dc095 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13780' file_name: Supplfig06_d_1.tif file_size: 501149 relation: main_file success: 1 - access_level: open_access checksum: 53df41dd968b04b4657cd2b91870d636 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:13Z date_updated: 2023-08-03T13:46:13Z file_id: '13781' file_name: Supplfig06_d_2.tif file_size: 500153 relation: main_file success: 1 - access_level: open_access checksum: 1a39b8310598dd25d97f848b682b8de0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13782' file_name: Supplfig06_d_3.tif file_size: 500153 relation: main_file success: 1 - access_level: open_access checksum: 6d9b496be6aecedbb2cb4cbf68f02872 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13783' file_name: Supplfig06_d_i.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: bc034b1636c2db8b9d9e7bd131b9780a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13784' file_name: Supplfig06_d_ii.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: 54f6e55e30a2aeea6c82eb6dbd376240 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13785' file_name: Supplfig06_d_iii.tif file_size: 78329 relation: main_file success: 1 - access_level: open_access checksum: 446da3cc16897277890f23f966c2bf52 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13786' file_name: Supplfig06_g_1.tif file_size: 960011 relation: main_file success: 1 - access_level: open_access checksum: 71192d0ec592a33195f2386a5f95aa86 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13787' file_name: Supplfig06_g_2.tif file_size: 960011 relation: main_file success: 1 - access_level: open_access checksum: 246782dbe8ff525aea360efc72e65f07 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13788' file_name: Supplfig06_g_3.tif file_size: 960041 relation: main_file success: 1 - access_level: open_access checksum: d49b12fec5508aa8d72587757cccc0a4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13789' file_name: Supplfig06_g_4.tif file_size: 960041 relation: main_file success: 1 - access_level: open_access checksum: 27b11b1d4fc784a49ffd7660624d00b6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:46:14Z date_updated: 2023-08-03T13:46:14Z file_id: '13790' file_name: Supplfig06_g_5.tif file_size: 963241 relation: main_file success: 1 - access_level: open_access checksum: 9ce944049c1b88fadbf43609385f9e2f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:38Z date_updated: 2023-08-03T13:51:38Z file_id: '13791' file_name: Suppl08_a_1.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 06265515f06688843a415362f7b2c485 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:38Z date_updated: 2023-08-03T13:51:38Z file_id: '13792' file_name: Suppl08_a_2.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 50f0969c6c2c1209ff776bec4861030a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:38Z date_updated: 2023-08-03T13:51:38Z file_id: '13793' file_name: Suppl08_a_3.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: b90965d20133fea73c99050c32eb7695 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:38Z date_updated: 2023-08-03T13:51:38Z file_id: '13794' file_name: Suppl08_a_4.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 568a1e0efaa62527b51e66a7aabfd05c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:40Z date_updated: 2023-08-03T13:51:40Z file_id: '13795' file_name: Suppl08_a_coCATS_N2V.tif file_size: 19287339 relation: main_file success: 1 - access_level: open_access checksum: 06265515f06688843a415362f7b2c485 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:40Z date_updated: 2023-08-03T13:51:40Z file_id: '13796' file_name: Suppl08_c_1_4_predictedBASSOON.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 568a1e0efaa62527b51e66a7aabfd05c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:43Z date_updated: 2023-08-03T13:51:43Z file_id: '13797' file_name: Suppl08_c_1_coCATS.tif file_size: 19287339 relation: main_file success: 1 - access_level: open_access checksum: feae08c38b1d9c540b697977cd7f2666 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T15:36:47Z date_updated: 2023-08-03T15:36:47Z file_id: '13798' file_name: Suppl08_c_2_coCATS.tif file_size: 19287340 relation: main_file success: 1 - access_level: open_access checksum: af2c1199fdcaecfec76189dae86cc12e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:44Z date_updated: 2023-08-03T13:51:44Z file_id: '13799' file_name: Suppl08_c_2-3_predictedBASSOON.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 1f92db47605959d0db01f612f7c9c034 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:43Z date_updated: 2023-08-03T13:51:43Z file_id: '13800' file_name: Suppl08_c_3-6_roi.roi file_size: 156 relation: main_file success: 1 - access_level: open_access checksum: 4fc4f8803adcfacd53a41b91f4699dc5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:45Z date_updated: 2023-08-03T13:51:45Z file_id: '13801' file_name: Suppl08_e_1_3.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 459551aae114daa4f5ca5d06fcd6b203 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:45Z date_updated: 2023-08-03T13:51:45Z file_id: '13802' file_name: Suppl08_e_1-2.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 032cbace7ec436f7b62478c0ffd35e5e content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:45Z date_updated: 2023-08-03T13:51:45Z file_id: '13803' file_name: Suppl08_e_2-5_roi.roi file_size: 152 relation: main_file success: 1 - access_level: open_access checksum: 7379168be281ef618b8cecd8efd31ed5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:46Z date_updated: 2023-08-03T13:51:46Z file_id: '13804' file_name: Suppl08_e_4-5_coCATS.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 5c4c092f608f4c10bb422c9e08b5955b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:46Z date_updated: 2023-08-03T13:51:46Z file_id: '13805' file_name: Suppl08_e_4.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 903e31be124f6e4ec1c2e7ab7db80e6b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:46Z date_updated: 2023-08-03T13:51:46Z file_id: '13806' file_name: Suppl08_e_5.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 173d956392d67b0a7e544629b51881e4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:48Z date_updated: 2023-08-03T13:51:48Z file_id: '13807' file_name: Suppl08_e_6_8.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 2a4cea867a253a6af7e9b0d2e100de14 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:48Z date_updated: 2023-08-03T13:51:48Z file_id: '13808' file_name: Suppl08_e_6-7.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 6b40f99fddfa26f0a9713000769741b7 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:48Z date_updated: 2023-08-03T13:51:48Z file_id: '13809' file_name: Suppl08_e_7-10_roi.roi file_size: 174 relation: main_file success: 1 - access_level: open_access checksum: 82f7013959df99c27366886de9b38ba2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13810' file_name: Suppl08_e_9-10_coCATS.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 50f0969c6c2c1209ff776bec4861030a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:48Z date_updated: 2023-08-03T13:51:48Z file_id: '13811' file_name: Suppl08_e_9.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 569f599d7f2be49d4dcf7cb385f428c4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13812' file_name: Suppl08_e_10.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 50f0969c6c2c1209ff776bec4861030a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13813' file_name: Suppl08_g_1.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: 62797fc860176197142a47e831eaf1f6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13814' file_name: Suppl08_g_2.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: b90965d20133fea73c99050c32eb7695 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13815' file_name: Suppl08_g_3.tif file_size: 617552 relation: main_file success: 1 - access_level: open_access checksum: a96dc9f38c6a1d3c959771a649a42748 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:49Z date_updated: 2023-08-03T13:51:49Z file_id: '13816' file_name: Suppl08_i_add_roi.roi file_size: 160 relation: main_file success: 1 - access_level: open_access checksum: f2135207ebbc4bdc014763ba852a5cf0 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:50Z date_updated: 2023-08-03T13:51:50Z file_id: '13817' file_name: Suppl08_i_shape_roi.roi file_size: 160 relation: main_file success: 1 - access_level: open_access checksum: f6f31fe2d87cf7208387f98ce1e37b04 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T13:51:50Z date_updated: 2023-08-03T13:51:50Z file_id: '13818' file_name: Suppl08_i_split_roi.roi file_size: 158 relation: main_file success: 1 - access_level: open_access checksum: 71590db0ad391e0c5baf03024981b1d9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:51Z date_updated: 2023-08-03T13:51:51Z file_id: '13819' file_name: Suppl08_i_1.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 9ce944049c1b88fadbf43609385f9e2f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:51Z date_updated: 2023-08-03T13:51:51Z file_id: '13820' file_name: Suppl08_i_2.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 06265515f06688843a415362f7b2c485 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:52Z date_updated: 2023-08-03T13:51:52Z file_id: '13821' file_name: Suppl08_i_3.tiff file_size: 19286002 relation: main_file success: 1 - access_level: open_access checksum: 16c628c160fb81e40df0ad1eb134e92b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:52Z date_updated: 2023-08-03T13:51:52Z file_id: '13822' file_name: Suppl08_i_4.tif file_size: 19284766 relation: main_file success: 1 - access_level: open_access checksum: b06e62c3a9834a40002d7aad3eaacc3f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:53Z date_updated: 2023-08-03T13:51:53Z file_id: '13823' file_name: Suppl08_i_5.tif file_size: 9649818 relation: main_file success: 1 - access_level: open_access checksum: 41ef98c7f01755b43cf6e77fff287732 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:51:53Z date_updated: 2023-08-03T13:51:53Z file_id: '13824' file_name: Suppl08_i_6.tif file_size: 19284766 relation: main_file success: 1 - access_level: open_access checksum: feae08c38b1d9c540b697977cd7f2666 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:53:29Z date_updated: 2023-08-03T13:53:29Z file_id: '13825' file_name: Suppl08_c_2_coCATS.tif file_size: 19287340 relation: main_file success: 1 - access_level: open_access checksum: c01509a1c657fbbbfdbbd484c298b6e3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:58:08Z date_updated: 2023-08-03T13:58:08Z file_id: '13826' file_name: Supplfig09_b_1_n2v.tiff file_size: 179788642 relation: main_file success: 1 - access_level: open_access checksum: 64a7f270274ff3480b18d690087016e2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:58:20Z date_updated: 2023-08-03T13:58:20Z file_id: '13827' file_name: Supplfig09_b_2_n2v.tif file_size: 742420240 relation: main_file success: 1 - access_level: open_access checksum: b34a6beaaf13698f421df961e009efeb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:58:20Z date_updated: 2023-08-03T13:58:20Z file_id: '13828' file_name: Supplfig09_b_3_n2v.tif file_size: 478900363 relation: main_file success: 1 - access_level: open_access checksum: ec04501f234b5e4fd91f9eac0e585395 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:58:25Z date_updated: 2023-08-03T13:58:25Z file_id: '13829' file_name: Supplfig09_b_4_n2v.tif file_size: 191873159 relation: main_file success: 1 - access_level: open_access checksum: 3a1b313298da35c97550abf0d245b4a7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:59:27Z date_updated: 2023-08-03T13:59:27Z file_id: '13830' file_name: Supplfig11_i.tif file_size: 55286 relation: main_file success: 1 - access_level: open_access checksum: 9cf00c0252f0a2efe1994c83c224389a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:59:27Z date_updated: 2023-08-03T13:59:27Z file_id: '13831' file_name: Supplfig11_ii.tif file_size: 55286 relation: main_file success: 1 - access_level: open_access checksum: 9a6e83acdf6d70bb9a6e76fa7d41a372 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:59:27Z date_updated: 2023-08-03T13:59:27Z file_id: '13832' file_name: Supplfig11_iii.tif file_size: 55257 relation: main_file success: 1 - access_level: open_access checksum: 709fdd13b7e090846a4d8edd2425f675 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T13:59:32Z date_updated: 2023-08-03T13:59:32Z file_id: '13833' file_name: Supplfig11_n2v+prediction.tif file_size: 309457551 relation: main_file success: 1 - access_level: open_access checksum: e60ea3e6bb1bf380460d0d8ccdbd1f07 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:32Z date_updated: 2023-08-03T14:14:32Z file_id: '13834' file_name: Supplfig12_a_01_n2v.tif file_size: 119323629 relation: main_file success: 1 - access_level: open_access checksum: 2a4e1771e2f06383894361ba2a8155b4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:29Z date_updated: 2023-08-03T14:14:29Z file_id: '13835' file_name: Supplfig12_a_01.tif file_size: 59680727 relation: main_file success: 1 - access_level: open_access checksum: 993c434069b9d1bcb09bfe70628f5bbe content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:34Z date_updated: 2023-08-03T14:14:34Z file_id: '13836' file_name: Supplfig12_a_02_n2v.tif file_size: 106696749 relation: main_file success: 1 - access_level: open_access checksum: e3b6410d68e42004ef3857967707aeb3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:34Z date_updated: 2023-08-03T14:14:34Z file_id: '13837' file_name: Supplfig12_a_02.tif file_size: 53367287 relation: main_file success: 1 - access_level: open_access checksum: 0156e99806fe1539d5f48ea16c78e8c8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:41Z date_updated: 2023-08-03T14:14:41Z file_id: '13838' file_name: Supplfig12_a_03_n2v.tif file_size: 149937979 relation: main_file success: 1 - access_level: open_access checksum: 6cc1533a221526a072a0b09fb44bcf50 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:39Z date_updated: 2023-08-03T14:14:39Z file_id: '13839' file_name: Supplfig12_a_03.tif file_size: 74987927 relation: main_file success: 1 - access_level: open_access checksum: f134834bd0d5e8c22e5a35aadf592007 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:53Z date_updated: 2023-08-03T14:14:53Z file_id: '13840' file_name: Supplfig12_a_04_n2v.tif file_size: 305581862 relation: main_file success: 1 - access_level: open_access checksum: 212ec76c02552fa1eef91e7bca9f07f7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:50Z date_updated: 2023-08-03T14:14:50Z file_id: '13841' file_name: Supplfig12_a_04.tif file_size: 152821840 relation: main_file success: 1 - access_level: open_access checksum: 7d99807d5b4313b04b4b5e0fbc08ba78 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:52Z date_updated: 2023-08-03T14:14:52Z file_id: '13842' file_name: Supplfig12_a_05_n2v.tif file_size: 48082029 relation: main_file success: 1 - access_level: open_access checksum: a6d4024a8c6fa073a532cc0c78323df7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:14:53Z date_updated: 2023-08-03T14:14:53Z file_id: '13843' file_name: Supplfig12_a_05.tif file_size: 24059983 relation: main_file success: 1 - access_level: open_access checksum: 1c42ad5423636478fe57495a3b506746 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:09Z date_updated: 2023-08-03T14:15:09Z file_id: '13844' file_name: Supplfig12_a_06_n2v.tif file_size: 305581860 relation: main_file success: 1 - access_level: open_access checksum: 821f1d31c6dbe68eb2513fb7520b5272 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:04Z date_updated: 2023-08-03T14:15:04Z file_id: '13845' file_name: Supplfig12_a_06.tif file_size: 152821840 relation: main_file success: 1 - access_level: open_access checksum: 86a4dc1e4948c4bc9c71e6d55b4fd104 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:08Z date_updated: 2023-08-03T14:15:08Z file_id: '13846' file_name: Supplfig12_a_07_n2v.tif file_size: 66855793 relation: main_file success: 1 - access_level: open_access checksum: fd5d45b1135800124fec635c4667dafe content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:09Z date_updated: 2023-08-03T14:15:09Z file_id: '13847' file_name: Supplfig12_a_07.tif file_size: 33446807 relation: main_file success: 1 - access_level: open_access checksum: 5683760cc119a09f0b7de8fea98cda9c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:19Z date_updated: 2023-08-03T14:15:19Z file_id: '13848' file_name: Supplfig12_a_08_n2v.tif file_size: 231476260 relation: main_file success: 1 - access_level: open_access checksum: 0c336d554bcd8524f11bd25c2188b56f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:15Z date_updated: 2023-08-03T14:15:15Z file_id: '13849' file_name: Supplfig12_a_08.tif file_size: 115769040 relation: main_file success: 1 - access_level: open_access checksum: fcaea6c95c363bd864a524fca8ed8e9b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:31Z date_updated: 2023-08-03T14:15:31Z file_id: '13850' file_name: Supplfig12_a_09_n2v.tif file_size: 305581869 relation: main_file success: 1 - access_level: open_access checksum: f401f1875f072c345d106a1e419f9d13 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:28Z date_updated: 2023-08-03T14:15:28Z file_id: '13851' file_name: Supplfig12_a_09.tif file_size: 152821840 relation: main_file success: 1 - access_level: open_access checksum: 7ad7d5b1ac81da1ec3d5003d00ee870a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:42Z date_updated: 2023-08-03T14:15:42Z file_id: '13852' file_name: Supplfig12_a_10_n2v.tif file_size: 266386255 relation: main_file success: 1 - access_level: open_access checksum: 77b93d082debd5248348c0a1e886eab9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:40Z date_updated: 2023-08-03T14:15:40Z file_id: '13853' file_name: Supplfig12_a_10.tif file_size: 133239040 relation: main_file success: 1 - access_level: open_access checksum: 5ece1d503f05133d07d5b867f666d7a8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:49Z date_updated: 2023-08-03T14:15:49Z file_id: '13854' file_name: Supplfig12_a_11_n2v.tif file_size: 191866269 relation: main_file success: 1 - access_level: open_access checksum: a72ee7ab433097752ff00a63421d4b61 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:15:48Z date_updated: 2023-08-03T14:15:48Z file_id: '13855' file_name: Supplfig12_a_11.tif file_size: 95955040 relation: main_file success: 1 - access_level: open_access checksum: c9c6e4692e0e7f305a43058b201b50d3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:16:49Z date_updated: 2023-08-03T14:16:49Z file_id: '13856' file_name: Supplfig13_i.tif file_size: 55281 relation: main_file success: 1 - access_level: open_access checksum: 345d11dbd70123d9d2723b547cbfc4fc content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:16:49Z date_updated: 2023-08-03T14:16:49Z file_id: '13857' file_name: Supplfig13_ii.tif file_size: 55193 relation: main_file success: 1 - access_level: open_access checksum: b4c74c08077cfd3e11bfd6ea9ee1c5b2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:16:49Z date_updated: 2023-08-03T14:16:49Z file_id: '13858' file_name: Supplfig13_n2v+predict.tif file_size: 539037 relation: main_file success: 1 - access_level: open_access checksum: 15f5b44257d075f9e45811304dfd5f85 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:18:10Z date_updated: 2023-08-03T14:18:10Z file_id: '13859' file_name: Supplfig14_a_n2v.tif file_size: 854898609 relation: main_file success: 1 - access_level: open_access checksum: a9ca03e3e5696988d06fc6ab1c103440 content_type: image/png creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13860' file_name: Supplfig15_a_1.png file_size: 7514502 relation: main_file success: 1 - access_level: open_access checksum: 4be3451e203a0fc5d9eb14279ff68a7a content_type: image/png creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13861' file_name: Supplfig15_a_2.png file_size: 1784041 relation: main_file success: 1 - access_level: open_access checksum: 43068c31eecddb798dbf2f51bda9b6c9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13862' file_name: Supplfig15_b_1.tif file_size: 6030878 relation: main_file success: 1 - access_level: open_access checksum: ded4c0797f1a9152dc3128f1bb8c32a5 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13863' file_name: Supplfig15_b_2.tif file_size: 723293 relation: main_file success: 1 - access_level: open_access checksum: 705394732d94bd8463479aee83c2d36e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13864' file_name: Supplfig15_c_i.tif file_size: 723409 relation: main_file success: 1 - access_level: open_access checksum: e08efe220bec6a93d583cab17754dd19 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:58Z date_updated: 2023-08-03T14:19:58Z file_id: '13865' file_name: Supplfig15_c_ii.tif file_size: 723409 relation: main_file success: 1 - access_level: open_access checksum: 0e08e5d965815240b0a8195e0f899aab content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:59Z date_updated: 2023-08-03T14:19:59Z file_id: '13866' file_name: Supplfig15_c.tif file_size: 31572914 relation: main_file success: 1 - access_level: open_access checksum: 594696a77d4a9be512046be5e2d602f0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:59Z date_updated: 2023-08-03T14:19:59Z file_id: '13867' file_name: Supplfig15_d_1.tif file_size: 6030752 relation: main_file success: 1 - access_level: open_access checksum: ffe6733eb77858008c4ca07b5f8c432b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:19:59Z date_updated: 2023-08-03T14:19:59Z file_id: '13868' file_name: Supplfig15_d_2.tif file_size: 8005495 relation: main_file success: 1 - access_level: open_access checksum: 663bf013cf1e5019e1e7ddd2d12fa492 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:20:56Z date_updated: 2023-08-03T14:20:56Z file_id: '13869' file_name: Supplfig16_a.tif file_size: 11117709 relation: main_file success: 1 - access_level: open_access checksum: 80aee233dc2a1f26ed8cc323270cf3a9 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:20:56Z date_updated: 2023-08-03T14:20:56Z file_id: '13870' file_name: Supplfig16_b.tif file_size: 113709 relation: main_file success: 1 - access_level: open_access checksum: 3b408e9345df2f16a942ad4ea61739b7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:20:56Z date_updated: 2023-08-03T14:20:56Z file_id: '13871' file_name: Supplfig16_c.tif file_size: 113709 relation: main_file success: 1 - access_level: open_access checksum: fbf688ef1f907149f92e9e936d02df72 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13872' file_name: Supplfig17_a_1.tif file_size: 6003131 relation: main_file success: 1 - access_level: open_access checksum: 9a56470f251f14b43903036fab338f76 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13873' file_name: Supplfig17_a_2.tif file_size: 8004085 relation: main_file success: 1 - access_level: open_access checksum: 4578c020ba5d0a6ffe2a8a1c22e52c75 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13874' file_name: Supplfig17_a_3.tif file_size: 6003123 relation: main_file success: 1 - access_level: open_access checksum: a681d32f515da3bff8e803946f1d8b50 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13875' file_name: Supplfig17_a_4.tif file_size: 6003131 relation: main_file success: 1 - access_level: open_access checksum: b89d366c39e25d17dc5d8ceee9145c8b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13876' file_name: Supplfig17_a_5.tif file_size: 6003131 relation: main_file success: 1 - access_level: open_access checksum: 0b9d60f0aba79525a97c122d972f0b22 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13877' file_name: Supplfig17_a_6.tif file_size: 6003079 relation: main_file success: 1 - access_level: open_access checksum: 169aad3cea521cc2a0ce4c3e41473e0c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13878' file_name: Supplfig17_a_7.tif file_size: 6003115 relation: main_file success: 1 - access_level: open_access checksum: 39a44d77d9047bfa10da8d9c9bd7b391 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:47Z date_updated: 2023-08-03T14:25:47Z file_id: '13879' file_name: Supplfig17_a_8.tif file_size: 4002129 relation: main_file success: 1 - access_level: open_access checksum: f4ecb2bd44f2cea3d71587670344ac40 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:25:48Z date_updated: 2023-08-03T14:25:48Z file_id: '13880' file_name: Supplfig17_b.tif file_size: 8214335 relation: main_file success: 1 - access_level: open_access checksum: 44a20d2621680c90227416bf32b5a566 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:27:06Z date_updated: 2023-08-03T14:27:06Z file_id: '13881' file_name: Supplfig18_a.tif file_size: 7471479 relation: main_file success: 1 - access_level: open_access checksum: 5a5f7b616785f9213064e8c77f9d38c4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:27:06Z date_updated: 2023-08-03T14:27:06Z file_id: '13882' file_name: Supplfig18_b.tif file_size: 290625 relation: main_file success: 1 - access_level: open_access checksum: 8f621722a636e808a03d85f9597ad1a2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:27:07Z date_updated: 2023-08-03T14:27:07Z file_id: '13883' file_name: Supplfig18_c.tif file_size: 411767 relation: main_file success: 1 - access_level: open_access checksum: 3c8356f9170fe345e2ef725cd7d1b167 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:27:07Z date_updated: 2023-08-03T14:27:07Z file_id: '13884' file_name: Supplfig18_d.tif file_size: 11117685 relation: main_file success: 1 - access_level: open_access checksum: 5c8443e97724b54f359f7355483b890e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:27:10Z date_updated: 2023-08-03T14:27:10Z file_id: '13885' file_name: Supplfig18_e_n2v.tif file_size: 259509773 relation: main_file success: 1 - access_level: open_access checksum: 413e3105c1bcd2ac2c569fa2b06253f2 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:29:25Z date_updated: 2023-08-03T14:29:25Z file_id: '13886' file_name: Supplfig19_n2v.tif file_size: 1430939360 relation: main_file success: 1 - access_level: open_access checksum: a864dc5b54f469c723e86286d538bb52 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:29:16Z date_updated: 2023-08-03T14:29:16Z file_id: '13887' file_name: Supplfig19.tif file_size: 715524468 relation: main_file success: 1 - access_level: open_access checksum: 8a78ce49446d207c0bf31196b788fa93 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13888' file_name: Supplfig20_a_left.tif file_size: 8004743 relation: main_file success: 1 - access_level: open_access checksum: 48fa3abfd16a00c7a3757d6452a482ec content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13889' file_name: Supplfig20_a_right.tif file_size: 5561081 relation: main_file success: 1 - access_level: open_access checksum: 85d82cd94dd3202f04b5987bc4466573 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13890' file_name: Supplfig20_b_1.tif file_size: 8456797 relation: main_file success: 1 - access_level: open_access checksum: e16f04d5d4d40f6ec33456d0cf02e1eb content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13891' file_name: Supplfig20_b_2.tif file_size: 8456795 relation: main_file success: 1 - access_level: open_access checksum: ff190edb269c28b25d27bffaeb7d25cf content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13892' file_name: Supplfig20_b_3.tif file_size: 8456796 relation: main_file success: 1 - access_level: open_access checksum: deb10b81bae62d9e20e681411fb75fcc content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13893' file_name: Supplfig20_b_4.tif file_size: 8538887 relation: main_file success: 1 - access_level: open_access checksum: 5c64bb94e76030d7a9d8624bac4b0f57 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13894' file_name: Supplfig20_b_5.tif file_size: 8538851 relation: main_file success: 1 - access_level: open_access checksum: d6c20232c4bd36e213b4c456c5009644 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13895' file_name: Supplfig20_c_1.tif file_size: 11077737 relation: main_file success: 1 - access_level: open_access checksum: 49c3396b8960af3f6fd8f6b078971d51 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:54Z date_updated: 2023-08-03T14:32:54Z file_id: '13896' file_name: Supplfig20_c_2.tif file_size: 11077737 relation: main_file success: 1 - access_level: open_access checksum: 73471528f691fb337839b84c31014da4 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13897' file_name: Supplfig20_c_3.tif file_size: 11077737 relation: main_file success: 1 - access_level: open_access checksum: 47a0fd1a36d7e7907ce18007bdaaa145 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13898' file_name: Supplfig20_c_4.tif file_size: 11077737 relation: main_file success: 1 - access_level: open_access checksum: 0c74b07f13fb08a91e61669368f38c9a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13899' file_name: Supplfig20_c_5.tif file_size: 11077737 relation: main_file success: 1 - access_level: open_access checksum: fe3b76446ec8bd0d5cdba94a128a84b8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13900' file_name: Supplfig20_d_1.tif file_size: 4002133 relation: main_file success: 1 - access_level: open_access checksum: 0570bab9a471af3d0d1d8bf9a3cb17e7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13901' file_name: Supplfig20_d_2.tif file_size: 4002133 relation: main_file success: 1 - access_level: open_access checksum: 59f330990b5c95f98a768761a009940c content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13902' file_name: Supplfig20_d_3.tif file_size: 4002199 relation: main_file success: 1 - access_level: open_access checksum: f0da06f2a278dff4bbd1aeace11700bf content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13903' file_name: Supplfig20_d_4.tif file_size: 4002133 relation: main_file success: 1 - access_level: open_access checksum: e61d49dcc0952af3623cc26a78cc6495 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:32:55Z date_updated: 2023-08-03T14:32:55Z file_id: '13904' file_name: Supplfig20_d_5.tif file_size: 4002133 relation: main_file success: 1 - access_level: open_access checksum: bcf8294487abaf1a75033f388fba06ec content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:01Z date_updated: 2023-08-03T14:42:01Z file_id: '13905' file_name: Supplfig22_b_1.tif file_size: 12627576 relation: main_file success: 1 - access_level: open_access checksum: 14097feb4a73e7bb1e1694cef0115cab content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:01Z date_updated: 2023-08-03T14:42:01Z file_id: '13906' file_name: Supplfig22_b_2.tif file_size: 8543366 relation: main_file success: 1 - access_level: open_access checksum: 7e74b8cff2ada56d47d135a6a9e71e76 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:04Z date_updated: 2023-08-03T14:42:04Z file_id: '13907' file_name: Supplfig22_b_3.tif file_size: 8394010 relation: main_file success: 1 - access_level: open_access checksum: f6e6e0f0e3854fedd201ab8ff08a7651 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T15:35:39Z date_updated: 2023-08-03T15:35:39Z file_id: '13908' file_name: Supplfig22_b_4.tif file_size: 8682992 relation: main_file success: 1 - access_level: open_access checksum: 6ddeb84249768b46b9c2072bf85bdc8b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:04Z date_updated: 2023-08-03T14:42:04Z file_id: '13909' file_name: Supplfig22_b_5.tif file_size: 8503466 relation: main_file success: 1 - access_level: open_access checksum: 40648b8a4ef375b8352f11a6772ea1a6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:04Z date_updated: 2023-08-03T14:42:04Z file_id: '13910' file_name: Supplfig22_b_6.tif file_size: 8543342 relation: main_file success: 1 - access_level: open_access checksum: 78f601de4d88f6ccb97861eaf4a995f8 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:06Z date_updated: 2023-08-03T14:42:06Z file_id: '13911' file_name: Supplfig22_b_7.tif file_size: 33588990 relation: main_file success: 1 - access_level: open_access checksum: 2873c488b7c8ad4d111726025086e9ea content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:42:41Z date_updated: 2023-08-03T14:42:41Z file_id: '13912' file_name: Supplfig22_c.tif file_size: 1453171518 relation: main_file success: 1 - access_level: open_access checksum: c1d0e5e61ac0d0ddf08704769f80ac78 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:47:43Z date_updated: 2023-08-03T14:47:43Z file_id: '13913' file_name: Supplfig23_a.tif file_size: 1325919782 relation: main_file success: 1 - access_level: open_access checksum: f97632984b6a73e06cc0c8c947cdcc71 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:47:25Z date_updated: 2023-08-03T14:47:25Z file_id: '13914' file_name: Supplfig23_b.tif file_size: 31366288 relation: main_file success: 1 - access_level: open_access checksum: 16f4c17835a79d7c06e2a97b1603baf1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:47:26Z date_updated: 2023-08-03T14:47:26Z file_id: '13915' file_name: Supplfig23_c.tif file_size: 31366288 relation: main_file success: 1 - access_level: open_access checksum: 00f35ca77165642ca9b3bc3608bd04c1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:47:27Z date_updated: 2023-08-03T14:47:27Z file_id: '13916' file_name: Supplfig23_d.tif file_size: 31366428 relation: main_file success: 1 - access_level: open_access checksum: 1aff850f47ae8c8f05ca48ff9faa38b1 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:47:27Z date_updated: 2023-08-03T14:47:27Z file_id: '13917' file_name: Supplfig23_e.tif file_size: 31500832 relation: main_file success: 1 - access_level: open_access checksum: f644de697d142c83461ed5ad1d72a043 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:48:38Z date_updated: 2023-08-03T14:48:38Z file_id: '13918' file_name: Supplfig24_a_i.tif file_size: 44179078 relation: main_file success: 1 - access_level: open_access checksum: eccb84925a6699b396d4b07efcbc7349 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:48:38Z date_updated: 2023-08-03T14:48:38Z file_id: '13919' file_name: Supplfig24_a_ii.tif file_size: 44125924 relation: main_file success: 1 - access_level: open_access checksum: afe7253e70ec79144e59b28c3c66703a content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:48:54Z date_updated: 2023-08-03T14:48:54Z file_id: '13920' file_name: Supplfig24_a.tif file_size: 1061835435 relation: main_file success: 1 - access_level: open_access checksum: 94a03b022aa84ea6e8515450a481ad82 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:48:39Z date_updated: 2023-08-03T14:48:39Z file_id: '13921' file_name: Supplfig24_b_iii.tif file_size: 3977824 relation: main_file success: 1 - access_level: open_access checksum: 166832c173fcda88ec6e35decdf0d197 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:48:39Z date_updated: 2023-08-03T14:48:39Z file_id: '13922' file_name: Supplfig24_b_iv.tif file_size: 3977825 relation: main_file success: 1 - access_level: open_access checksum: 53175073b83ab569241ae64ef7f180b3 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:51:27Z date_updated: 2023-08-03T14:51:27Z file_id: '13923' file_name: Supplfig25_a_1.tif file_size: 37641738 relation: main_file success: 1 - access_level: open_access checksum: 70e6a1780daeae6a5bef2c27c996c442 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:51:26Z date_updated: 2023-08-03T14:51:26Z file_id: '13924' file_name: Supplfig25_a_2.tif file_size: 4932897 relation: main_file success: 1 - access_level: open_access checksum: 1748266d7b8a2ae1f6292b9c265c2068 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:51:31Z date_updated: 2023-08-03T14:51:31Z file_id: '13925' file_name: Supplfig25_b_1.tif file_size: 357433570 relation: main_file success: 1 - access_level: open_access checksum: 8490f44160a482ea06d858eb3bc25a11 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:51:27Z date_updated: 2023-08-03T14:51:27Z file_id: '13926' file_name: Supplfig25_b_2.tif file_size: 27734506 relation: main_file success: 1 - access_level: open_access checksum: e5e9c550cc934a7725dc209c79951847 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:43Z date_updated: 2023-08-03T14:53:43Z file_id: '13927' file_name: Suppfig26_h.tif file_size: 35082394 relation: main_file success: 1 - access_level: open_access checksum: 39ae411d1e950e78bdc12937fb36f661 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:42Z date_updated: 2023-08-03T14:53:42Z file_id: '13928' file_name: Supplfig26_a_1.tif file_size: 16676477 relation: main_file success: 1 - access_level: open_access checksum: 450f5d0e8091639e27eb7a7991524e88 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:42Z date_updated: 2023-08-03T14:53:42Z file_id: '13929' file_name: Supplfig26_a_2.tif file_size: 170493 relation: main_file success: 1 - access_level: open_access checksum: 8e5a71801fa1fcb7f679d1af23344662 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:43Z date_updated: 2023-08-03T14:53:43Z file_id: '13930' file_name: Supplfig26_b_1.tif file_size: 11117737 relation: main_file success: 1 - access_level: open_access checksum: 519fb0326a0f0774b3edc1dafffcdd08 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:43Z date_updated: 2023-08-03T14:53:43Z file_id: '13931' file_name: Supplfig26_b_2.tif file_size: 113753 relation: main_file success: 1 - access_level: open_access checksum: d051c7d717eeb6f2ca59d8727ea62200 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:52Z date_updated: 2023-08-03T14:53:52Z file_id: '13932' file_name: Supplfig26_c.tif file_size: 495452386 relation: main_file success: 1 - access_level: open_access checksum: 5437b53e708572e2e9ad1432c260a04f content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:46Z date_updated: 2023-08-03T14:53:46Z file_id: '13933' file_name: Supplfig26_d.tif file_size: 132167170 relation: main_file success: 1 - access_level: open_access checksum: 0baab38829a8587ded5e39f85068124b content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:46Z date_updated: 2023-08-03T14:53:46Z file_id: '13934' file_name: Supplfig26_e.tif file_size: 11431214 relation: main_file success: 1 - access_level: open_access checksum: afa57f254c9dd987d90d5e43db3fb9e6 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:48Z date_updated: 2023-08-03T14:53:48Z file_id: '13935' file_name: Supplfig26_f.tif file_size: 64005702 relation: main_file success: 1 - access_level: open_access checksum: c35ba67ab92c410cb4370f91f3dea819 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:53:52Z date_updated: 2023-08-03T14:53:52Z file_id: '13936' file_name: Supplfig26_g.tif file_size: 246421054 relation: main_file success: 1 - access_level: open_access checksum: 3fd6186d73cbce1be79cf14a94a7f3bd content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:43Z date_updated: 2023-08-03T14:56:43Z file_id: '13937' file_name: Supplfig27_a.tif file_size: 166614932 relation: main_file success: 1 - access_level: open_access checksum: d1fc4c88e8e258e4e536a26e196d09b0 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:42Z date_updated: 2023-08-03T14:56:42Z file_id: '13938' file_name: Supplfig27_b.tif file_size: 143583446 relation: main_file success: 1 - access_level: open_access checksum: 8d6985530e86f38548e89e6380d73771 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:47Z date_updated: 2023-08-03T14:56:47Z file_id: '13939' file_name: Supplfig27_c.tif file_size: 172528188 relation: main_file success: 1 - access_level: open_access checksum: d0b1309d2120892ede84e04fdf0dbfbf content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:46Z date_updated: 2023-08-03T14:56:46Z file_id: '13940' file_name: Supplfig27_d.tif file_size: 113699256 relation: main_file success: 1 - access_level: open_access checksum: 4789b5254d0415ce314fc9e39cc52121 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:47Z date_updated: 2023-08-03T14:56:47Z file_id: '13941' file_name: Supplfig27_e.tif file_size: 88664548 relation: main_file success: 1 - access_level: open_access checksum: 7ff2d06534f062b0f17dab181f6c1f4e content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:47Z date_updated: 2023-08-03T14:56:47Z file_id: '13942' file_name: Supplfig27_f.tif file_size: 2298356 relation: main_file success: 1 - access_level: open_access checksum: 46de66d457b0def90f753c11927536b7 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:47Z date_updated: 2023-08-03T14:56:47Z file_id: '13943' file_name: Supplfig27_g_1.tif file_size: 499618 relation: main_file success: 1 - access_level: open_access checksum: 9ef5fba064a73a79dbc74b5e166d08ec content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:50Z date_updated: 2023-08-03T14:56:50Z file_id: '13944' file_name: Supplfig27_g_2.tif file_size: 202079026 relation: main_file success: 1 - access_level: open_access checksum: bf956c2b58d3da2baa869db5206d8d49 content_type: image/tiff creator: jdanzl date_created: 2023-08-03T14:56:48Z date_updated: 2023-08-03T14:56:48Z file_id: '13945' file_name: Supplfig27_g_3.tif file_size: 14639269 relation: main_file success: 1 - access_level: open_access checksum: 327dca11f42d5375d7f47f4cbd5b36c0 content_type: application/octet-stream creator: jdanzl date_created: 2023-08-03T15:21:01Z date_updated: 2023-08-03T15:21:01Z file_id: '13946' file_name: model.p file_size: 279467712 relation: main_file success: 1 file_date_updated: 2023-08-04T13:19:47Z has_accepted_license: '1' month: '08' oa: 1 oa_version: Published Version project: - _id: 265CB4D0-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03600 name: Optical control of synaptic function via adhesion molecules - _id: 26AA4EF2-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232-B24 name: Molecular Drug Targets - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: Synaptic communication in neuronal microcircuits - _id: 23889792-32DE-11EA-91FC-C7463DDC885E grant_number: LS18-022 name: High content imaging to decode human immune cell interactions in health and allergic disease - _id: 25444568-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715508' name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9 call_identifier: H2020 grant_number: '101026635' name: Synaptic computations of the hippocampal CA3 circuitry publisher: Institute of Science and Technology Austria related_material: link: - description: 'Original data for Fig. 5d, Fig. 5d (N2V) and Fig. 5f-i, provided via an external link due to the large size (>10GB) of the datasets. ' relation: research_data url: https://pub.ista.ac.at/group_danzl/data/CATS/ record: - id: '14257' relation: used_in_publication status: public status: public title: Research data for the publication "Imaging brain tissue architecture across millimeter to nanometer scales" tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: research_data user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2023' ... --- OA_place: publisher OA_type: hybrid _id: '13267' abstract: - lang: eng text: Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics and structure–function relationships of the brain’s complex and dense information processing network; however, this has been hindered by insufficient 3D resolution, inadequate signal-to-noise ratio and prohibitive light burden in optical imaging, whereas electron microscopy is inherently static. Here we solved these challenges by developing an integrated optical/machine-learning technology, LIONESS (live information-optimized nanoscopy enabling saturated segmentation). This leverages optical modifications to stimulated emission depletion microscopy in comprehensively, extracellularly labeled tissue and previous information on sample structure via machine learning to simultaneously achieve isotropic super-resolution, high signal-to-noise ratio and compatibility with living tissue. This allows dense deep-learning-based instance segmentation and 3D reconstruction at a synapse level, incorporating molecular, activity and morphodynamic information. LIONESS opens up avenues for studying the dynamic functional (nano-)architecture of living brain tissue. acknowledged_ssus: - _id: ScienComp - _id: Bio - _id: PreCl - _id: E-Lib - _id: LifeSc - _id: M-Shop acknowledgement: "We thank J. Vorlaufer, N. Agudelo and A. Wartak for microscope maintenance and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, M. Šuplata for hardware control support and M. Cunha dos Santos for initial exploration of software. We\r\nthank P. Henderson for advice on deep-learning training and M. Sixt, S. Boyd and T. Weiss for discussions and critical reading of the manuscript. L. Lavis (Janelia Research Campus) generously provided the JF585-HaloTag ligand. We acknowledge expert support by IST\r\nAustria’s scientific computing, imaging and optics, preclinical, library and laboratory support facilities and by the Miba machine shop. We gratefully acknowledge funding by the following sources: Austrian Science Fund (F.W.F.) grant no. I3600-B27 (J.G.D.), grant no. DK W1232\r\n(J.G.D. and J.M.M.) and grant no. Z 312-B27, Wittgenstein award (P.J.); the Gesellschaft für Forschungsförderung NÖ grant no. LSC18-022 (J.G.D.); an ISTA Interdisciplinary project grant (J.G.D. and B.B.); the European Union’s Horizon 2020 research and innovation programme,\r\nMarie-Skłodowska Curie grant 665385 (J.M.M. and J.L.); the European Union’s Horizon 2020 research and innovation programme, European Research Council grant no. 715767, MATERIALIZABLE (B.B.); grant no. 715508, REVERSEAUTISM (G.N.); grant no. 695568, SYNNOVATE (S.G.N.G.); and grant no. 692692, GIANTSYN (P.J.); the Simons\r\nFoundation Autism Research Initiative grant no. 529085 (S.G.N.G.); the Wellcome Trust Technology Development grant no. 202932 (S.G.N.G.); the Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.);\r\nthe Human Frontier Science Program postdoctoral fellowship LT000557/2018 (W.J.); and the National Science Foundation grant no. IIS-1835231 (H.P.) and NCS-FO-2124179 (H.P.)." article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Philipp full_name: Velicky, Philipp id: 39BDC62C-F248-11E8-B48F-1D18A9856A87 last_name: Velicky orcid: 0000-0002-2340-7431 - first_name: Eder full_name: Miguel Villalba, Eder id: 3FB91342-F248-11E8-B48F-1D18A9856A87 last_name: Miguel Villalba orcid: 0000-0001-5665-0430 - first_name: Julia M full_name: Michalska, Julia M id: 443DB6DE-F248-11E8-B48F-1D18A9856A87 last_name: Michalska orcid: 0000-0003-3862-1235 - first_name: Julia full_name: Lyudchik, Julia id: 46E28B80-F248-11E8-B48F-1D18A9856A87 last_name: Lyudchik - first_name: Donglai full_name: Wei, Donglai last_name: Wei - first_name: Zudi full_name: Lin, Zudi last_name: Lin - first_name: Jake full_name: Watson, Jake id: 63836096-4690-11EA-BD4E-32803DDC885E last_name: Watson orcid: 0000-0002-8698-3823 - first_name: Jakob full_name: Troidl, Jakob last_name: Troidl - first_name: Johanna full_name: Beyer, Johanna last_name: Beyer - first_name: Yoav full_name: Ben Simon, Yoav id: 43DF3136-F248-11E8-B48F-1D18A9856A87 last_name: Ben Simon - first_name: Christoph M full_name: Sommer, Christoph M id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87 last_name: Sommer orcid: 0000-0003-1216-9105 - first_name: Wiebke full_name: Jahr, Wiebke id: 425C1CE8-F248-11E8-B48F-1D18A9856A87 last_name: Jahr orcid: 0000-0003-0201-2315 - first_name: Alban full_name: Cenameri, Alban id: 9ac8f577-2357-11eb-997a-e566c5550886 last_name: Cenameri - first_name: Johannes full_name: Broichhagen, Johannes last_name: Broichhagen - first_name: Seth G.N. full_name: Grant, Seth G.N. last_name: Grant - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 - first_name: Hanspeter full_name: Pfister, Hanspeter last_name: Pfister - first_name: Bernd full_name: Bickel, Bernd id: 49876194-F248-11E8-B48F-1D18A9856A87 last_name: Bickel orcid: 0000-0001-6511-9385 - first_name: Johann G full_name: Danzl, Johann G id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87 last_name: Danzl orcid: 0000-0001-8559-3973 citation: ama: Velicky P, Miguel Villalba E, Michalska JM, et al. Dense 4D nanoscale reconstruction of living brain tissue. Nature Methods. 2023;20:1256-1265. doi:10.1038/s41592-023-01936-6 apa: Velicky, P., Miguel Villalba, E., Michalska, J. M., Lyudchik, J., Wei, D., Lin, Z., … Danzl, J. G. (2023). Dense 4D nanoscale reconstruction of living brain tissue. Nature Methods. Springer Nature. https://doi.org/10.1038/s41592-023-01936-6 chicago: Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Julia Lyudchik, Donglai Wei, Zudi Lin, Jake Watson, et al. “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.” Nature Methods. Springer Nature, 2023. https://doi.org/10.1038/s41592-023-01936-6. ieee: P. Velicky et al., “Dense 4D nanoscale reconstruction of living brain tissue,” Nature Methods, vol. 20. Springer Nature, pp. 1256–1265, 2023. ista: Velicky P, Miguel Villalba E, Michalska JM, Lyudchik J, Wei D, Lin Z, Watson J, Troidl J, Beyer J, Ben Simon Y, Sommer CM, Jahr W, Cenameri A, Broichhagen J, Grant SGN, Jonas PM, Novarino G, Pfister H, Bickel B, Danzl JG. 2023. Dense 4D nanoscale reconstruction of living brain tissue. Nature Methods. 20, 1256–1265. mla: Velicky, Philipp, et al. “Dense 4D Nanoscale Reconstruction of Living Brain Tissue.” Nature Methods, vol. 20, Springer Nature, 2023, pp. 1256–65, doi:10.1038/s41592-023-01936-6. short: P. Velicky, E. Miguel Villalba, J.M. Michalska, J. Lyudchik, D. Wei, Z. Lin, J. Watson, J. Troidl, J. Beyer, Y. Ben Simon, C.M. Sommer, W. Jahr, A. Cenameri, J. Broichhagen, S.G.N. Grant, P.M. Jonas, G. Novarino, H. Pfister, B. Bickel, J.G. Danzl, Nature Methods 20 (2023) 1256–1265. corr_author: '1' date_created: 2023-07-23T22:01:13Z date_published: 2023-08-01T00:00:00Z date_updated: 2026-07-06T12:49:46Z day: '01' ddc: - '570' department: - _id: PeJo - _id: GaNo - _id: BeBi - _id: JoDa - _id: Bio doi: 10.1038/s41592-023-01936-6 ec_funded: 1 external_id: isi: - '001025621500001' pmid: - '37429995' file: - access_level: open_access checksum: a68e845780a82ea36d0d4d3212a87c10 content_type: application/pdf creator: dernst date_created: 2025-02-26T08:01:57Z date_updated: 2025-02-26T08:01:57Z file_id: '19088' file_name: 2023_NatureMethods_Velicky.pdf file_size: 14103039 relation: main_file success: 1 file_date_updated: 2025-02-26T08:01:57Z has_accepted_license: '1' intvolume: ' 20' isi: 1 language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: 1256-1265 pmid: 1 project: - _id: 265CB4D0-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I03600 name: Optical control of synaptic function via adhesion molecules - _id: 2548AE96-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: W1232 name: Molecular Drug Targets - _id: 25C5A090-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: Z00312 name: Synaptic communication in neuronal microcircuits - _id: 23889792-32DE-11EA-91FC-C7463DDC885E grant_number: LS18-022 name: High content imaging to decode human immune cell interactions in health and allergic disease - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 24F9549A-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715767' name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling' - _id: 25444568-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715508' name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models - _id: 25B7EB9E-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '692692' name: Biophysics and circuit function of a giant cortical glutamatergic synapse - _id: fc2be41b-9c52-11eb-aca3-faa90aa144e9 call_identifier: H2020 grant_number: '101026635' name: Synaptic computations of the hippocampal CA3 circuitry - _id: 2668BFA0-B435-11E9-9278-68D0E5697425 grant_number: LT00057 name: High-speed 3D-nanoscopy to study the role of adhesion during 3D cell migration publication: Nature Methods publication_identifier: eissn: - 1548-7105 issn: - 1548-7091 publication_status: published publisher: Springer Nature quality_controlled: '1' related_material: link: - relation: software url: https://github.com/danzllab/LIONESS record: - id: '12817' relation: research_data status: public - id: '14770' relation: shorter_version status: public - id: '18674' relation: dissertation_contains status: public - id: '11943' relation: earlier_version status: public scopus_import: '1' status: public title: Dense 4D nanoscale reconstruction of living brain tissue tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 20 year: '2023' ... --- OA_place: publisher _id: '9418' abstract: - lang: eng text: "Deep learning is best known for its empirical success across a wide range of applications\r\nspanning computer vision, natural language processing and speech. Of equal significance,\r\nthough perhaps less known, are its ramifications for learning theory: deep networks have\r\nbeen observed to perform surprisingly well in the high-capacity regime, aka the overfitting\r\nor underspecified regime. Classically, this regime on the far right of the bias-variance curve\r\nis associated with poor generalisation; however, recent experiments with deep networks\r\nchallenge this view.\r\n\r\nThis thesis is devoted to investigating various aspects of underspecification in deep learning.\r\nFirst, we argue that deep learning models are underspecified on two levels: a) any given\r\ntraining dataset can be fit by many different functions, and b) any given function can be\r\nexpressed by many different parameter configurations. We refer to the second kind of\r\nunderspecification as parameterisation redundancy and we precisely characterise its extent.\r\nSecond, we characterise the implicit criteria (the inductive bias) that guide learning in the\r\nunderspecified regime. Specifically, we consider a nonlinear but tractable classification\r\nsetting, and show that given the choice, neural networks learn classifiers with a large margin.\r\nThird, we consider learning scenarios where the inductive bias is not by itself sufficient to\r\ndeal with underspecification. We then study different ways of ‘tightening the specification’: i)\r\nIn the setting of representation learning with variational autoencoders, we propose a hand-\r\ncrafted regulariser based on mutual information. ii) In the setting of binary classification, we\r\nconsider soft-label (real-valued) supervision. We derive a generalisation bound for linear\r\nnetworks supervised in this way and verify that soft labels facilitate fast learning. Finally, we\r\nexplore an application of soft-label supervision to the training of multi-exit models." acknowledged_ssus: - _id: ScienComp - _id: CampIT - _id: E-Lib alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Phuong full_name: Bui Thi Mai, Phuong id: 3EC6EE64-F248-11E8-B48F-1D18A9856A87 last_name: Bui Thi Mai citation: ama: Phuong M. Underspecification in deep learning. 2021. doi:10.15479/AT:ISTA:9418 apa: Phuong, M. (2021). Underspecification in deep learning. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:9418 chicago: Phuong, Mary. “Underspecification in Deep Learning.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/AT:ISTA:9418. ieee: M. Phuong, “Underspecification in deep learning,” Institute of Science and Technology Austria, 2021. ista: Phuong M. 2021. Underspecification in deep learning. Institute of Science and Technology Austria. mla: Phuong, Mary. Underspecification in Deep Learning. Institute of Science and Technology Austria, 2021, doi:10.15479/AT:ISTA:9418. short: M. Phuong, Underspecification in Deep Learning, Institute of Science and Technology Austria, 2021. corr_author: '1' date_created: 2021-05-24T13:06:23Z date_published: 2021-05-30T00:00:00Z date_updated: 2026-04-08T07:01:17Z day: '30' ddc: - '000' degree_awarded: PhD department: - _id: GradSch - _id: ChLa doi: 10.15479/AT:ISTA:9418 file: - access_level: open_access checksum: 4f0abe64114cfed264f9d36e8d1197e3 content_type: application/pdf creator: bphuong date_created: 2021-05-24T11:22:29Z date_updated: 2021-05-24T11:22:29Z file_id: '9419' file_name: mph-thesis-v519-pdfimages.pdf file_size: 2673905 relation: main_file success: 1 - access_level: closed checksum: f5699e876bc770a9b0df8345a77720a2 content_type: application/zip creator: bphuong date_created: 2021-05-24T11:56:02Z date_updated: 2021-05-24T11:56:02Z file_id: '9420' file_name: thesis.zip file_size: 92995100 relation: source_file file_date_updated: 2021-05-24T11:56:02Z has_accepted_license: '1' language: - iso: eng month: '05' oa: 1 oa_version: Published Version page: '125' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '7435' relation: part_of_dissertation status: deleted - id: '7481' relation: part_of_dissertation status: public - id: '9416' relation: part_of_dissertation status: public - id: '7479' relation: part_of_dissertation status: public status: public supervisor: - first_name: Christoph full_name: Lampert, Christoph id: 40C20FD2-F248-11E8-B48F-1D18A9856A87 last_name: Lampert orcid: 0000-0001-8622-7887 title: Underspecification in deep learning type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2021' ... --- OA_place: publisher _id: '8032' abstract: - lang: eng text: "Algorithms in computational 3-manifold topology typically take a triangulation as an input and return topological information about the underlying 3-manifold. However, extracting the desired information from a triangulation (e.g., evaluating an invariant) is often computationally very expensive. In recent years this complexity barrier has been successfully tackled in some cases by importing ideas from the theory of parameterized algorithms into the realm of 3-manifolds. Various computationally hard problems were shown to be efficiently solvable for input triangulations that are sufficiently “tree-like.”\r\nIn this thesis we focus on the key combinatorial parameter in the above context: we consider the treewidth of a compact, orientable 3-manifold, i.e., the smallest treewidth of the dual graph of any triangulation thereof. By building on the work of Scharlemann–Thompson and Scharlemann–Schultens–Saito on generalized Heegaard splittings, and on the work of Jaco–Rubinstein on layered triangulations, we establish quantitative relations between the treewidth and classical topological invariants of a 3-manifold. In particular, among other results, we show that the treewidth of a closed, orientable, irreducible, non-Haken 3-manifold is always within a constant factor of its Heegaard genus." acknowledged_ssus: - _id: E-Lib - _id: CampIT alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Kristóf full_name: Huszár, Kristóf id: 33C26278-F248-11E8-B48F-1D18A9856A87 last_name: Huszár orcid: 0000-0002-5445-5057 citation: ama: Huszár K. Combinatorial width parameters for 3-dimensional manifolds. 2020. doi:10.15479/AT:ISTA:8032 apa: Huszár, K. (2020). Combinatorial width parameters for 3-dimensional manifolds. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8032 chicago: Huszár, Kristóf. “Combinatorial Width Parameters for 3-Dimensional Manifolds.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8032. ieee: K. Huszár, “Combinatorial width parameters for 3-dimensional manifolds,” Institute of Science and Technology Austria, 2020. ista: Huszár K. 2020. Combinatorial width parameters for 3-dimensional manifolds. Institute of Science and Technology Austria. mla: Huszár, Kristóf. Combinatorial Width Parameters for 3-Dimensional Manifolds. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8032. short: K. Huszár, Combinatorial Width Parameters for 3-Dimensional Manifolds, Institute of Science and Technology Austria, 2020. corr_author: '1' date_created: 2020-06-26T10:00:36Z date_published: 2020-06-26T00:00:00Z date_updated: 2026-04-08T07:21:28Z day: '26' ddc: - '514' degree_awarded: PhD department: - _id: UlWa doi: 10.15479/AT:ISTA:8032 file: - access_level: open_access checksum: bd8be6e4f1addc863dfcc0fad29ee9c3 content_type: application/pdf creator: khuszar date_created: 2020-06-26T10:03:58Z date_updated: 2020-07-14T12:48:08Z file_id: '8034' file_name: Kristof_Huszar-Thesis.pdf file_size: 2637562 relation: main_file - access_level: closed checksum: d5f8456202b32f4a77552ef47a2837d1 content_type: application/x-zip-compressed creator: khuszar date_created: 2020-06-26T10:10:06Z date_updated: 2020-07-14T12:48:08Z file_id: '8035' file_name: Kristof_Huszar-Thesis-source.zip file_size: 7163491 relation: source_file file_date_updated: 2020-07-14T12:48:08Z has_accepted_license: '1' language: - iso: eng month: '06' oa: 1 oa_version: Published Version page: xviii+120 publication_identifier: isbn: - 978-3-99078-006-0 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '6556' relation: dissertation_contains status: public - id: '7093' relation: dissertation_contains status: public status: public supervisor: - first_name: Uli full_name: Wagner, Uli id: 36690CA2-F248-11E8-B48F-1D18A9856A87 last_name: Wagner orcid: 0000-0002-1494-0568 - first_name: Jonathan full_name: Spreer, Jonathan last_name: Spreer title: Combinatorial width parameters for 3-dimensional manifolds tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2020' ... --- OA_place: publisher _id: '8983' abstract: - lang: eng text: Metabolic adaptation is a critical feature of migrating cells. It tunes the metabolic programs of migrating cells to allow them to efficiently exert their crucial roles in development, inflammatory responses and tumor metastasis. Cell migration through physically challenging contexts requires energy. However, how the metabolic reprogramming that underlies in vivo cell invasion is controlled is still unanswered. In my PhD project, I identify a novel conserved metabolic shift in Drosophila melanogaster immune cells that by modulating their bioenergetic potential controls developmentally programmed tissue invasion. We show that this regulation requires a novel conserved nuclear protein, named Atossa. Atossa enhances the transcription of a set of proteins, including an RNA helicase Porthos and two metabolic enzymes, each of which increases the tissue invasion of leading Drosophila macrophages and can rescue the atossa mutant phenotype. Porthos selectively regulates the translational efficiency of a subset of mRNAs containing a 5’-UTR cis-regulatory TOP-like sequence. These 5’TOPL mRNA targets encode mitochondrial-related proteins, including subunits of mitochondrial oxidative phosphorylation (OXPHOS) components III and V and other metabolic-related proteins. Porthos powers up mitochondrial OXPHOS to engender a sufficient ATP supply, which is required for tissue invasion of leading macrophages. Atossa’s two vertebrate orthologs rescue the invasion defect. In my PhD project, I elucidate that Atossa displays a conserved developmental metabolic control to modulate metabolic capacities and the cellular energy state, through altered transcription and translation, to aid the tissue infiltration of leading cells into energy demanding barriers. acknowledged_ssus: - _id: Bio - _id: LifeSc - _id: E-Lib - _id: CampIT acknowledgement: Also, I would like to express my appreciation and thanks to the Bioimaging facility, LSF, GSO, library, and IT people at IST Austria. alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Shamsi full_name: Emtenani, Shamsi id: 49D32318-F248-11E8-B48F-1D18A9856A87 last_name: Emtenani orcid: 0000-0001-6981-6938 citation: ama: Emtenani S. Metabolic regulation of Drosophila macrophage tissue invasion. 2020. doi:10.15479/AT:ISTA:8983 apa: Emtenani, S. (2020). Metabolic regulation of Drosophila macrophage tissue invasion. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8983 chicago: Emtenani, Shamsi. “Metabolic Regulation of Drosophila Macrophage Tissue Invasion.” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8983. ieee: S. Emtenani, “Metabolic regulation of Drosophila macrophage tissue invasion,” Institute of Science and Technology Austria, 2020. ista: Emtenani S. 2020. Metabolic regulation of Drosophila macrophage tissue invasion. Institute of Science and Technology Austria. mla: Emtenani, Shamsi. Metabolic Regulation of Drosophila Macrophage Tissue Invasion. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8983. short: S. Emtenani, Metabolic Regulation of Drosophila Macrophage Tissue Invasion, Institute of Science and Technology Austria, 2020. corr_author: '1' date_created: 2020-12-30T15:41:26Z date_published: 2020-12-30T00:00:00Z date_updated: 2026-04-08T07:28:54Z day: '30' ddc: - '570' degree_awarded: PhD department: - _id: DaSi doi: 10.15479/AT:ISTA:8983 file: - access_level: open_access checksum: ec2797ab7a6f253b35df0572b36d1b43 content_type: application/pdf creator: semtenan date_created: 2020-12-30T15:34:01Z date_updated: 2021-12-31T23:30:04Z embargo: 2021-12-30 file_id: '8984' file_name: Thesis_Shamsi_Emtenani_pdfA.pdf file_size: 10848175 relation: main_file - access_level: closed checksum: cc30e6608a9815414024cf548dff3b3a content_type: application/pdf creator: semtenan date_created: 2020-12-30T15:37:36Z date_updated: 2021-12-31T23:30:04Z embargo_to: open_access file_id: '8985' file_name: Thesis_Shamsi_Emtenani_source file.pdf file_size: 10073648 relation: source_file file_date_updated: 2021-12-31T23:30:04Z has_accepted_license: '1' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: '141' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '8557' relation: part_of_dissertation status: public - id: '6187' relation: part_of_dissertation status: public status: public supervisor: - first_name: Daria E full_name: Siekhaus, Daria E id: 3D224B9E-F248-11E8-B48F-1D18A9856A87 last_name: Siekhaus orcid: 0000-0001-8323-8353 title: Metabolic regulation of Drosophila macrophage tissue invasion type: dissertation user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd year: '2020' ...