---
_id: '401'
abstract:
- lang: eng
  text: The actomyosin cytoskeleton, a key stress-producing unit in epithelial cells,
    oscillates spontaneously in a wide variety of systems. Although much of the signal
    cascade regulating myosin activity has been characterized, the origin of such
    oscillatory behavior is still unclear. Here, we show that basal myosin II oscillation
    in Drosophila ovarian epithelium is not controlled by actomyosin cortical tension,
    but instead relies on a biochemical oscillator involving ROCK and myosin phosphatase.
    Key to this oscillation is a diffusive ROCK flow, linking junctional Rho1 to medial
    actomyosin cortex, and dynamically maintained by a self-activation loop reliant
    on ROCK kinase activity. In response to the resulting myosin II recruitment, myosin
    phosphatase is locally enriched and shuts off ROCK and myosin II signals. Coupling
    Drosophila genetics, live imaging, modeling, and optogenetics, we uncover an intrinsic
    biochemical oscillator at the core of myosin II regulatory network, shedding light
    on the spatio-temporal dynamics of force generation.
article_number: '1210'
article_processing_charge: No
author:
- first_name: Xiang
  full_name: Qin, Xiang
  last_name: Qin
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Thomas
  full_name: Mangeat, Thomas
  last_name: Mangeat
- first_name: Chang
  full_name: Liu, Chang
  last_name: Liu
- first_name: Pralay
  full_name: Majumder, Pralay
  last_name: Majumder
- first_name: Jjiaying
  full_name: Liu, Jjiaying
  last_name: Liu
- first_name: Valerie
  full_name: Choesmel Cadamuro, Valerie
  last_name: Choesmel Cadamuro
- first_name: Jocelyn
  full_name: Mcdonald, Jocelyn
  last_name: Mcdonald
- first_name: Yinyao
  full_name: Liu, Yinyao
  last_name: Liu
- first_name: Bin
  full_name: Yi, Bin
  last_name: Yi
- first_name: Xiaobo
  full_name: Wang, Xiaobo
  last_name: Wang
citation:
  ama: Qin X, Hannezo EB, Mangeat T, et al. A biochemical network controlling basal
    myosin oscillation. <i>Nature Communications</i>. 2018;9(1). doi:<a href="https://doi.org/10.1038/s41467-018-03574-5">10.1038/s41467-018-03574-5</a>
  apa: Qin, X., Hannezo, E. B., Mangeat, T., Liu, C., Majumder, P., Liu, J., … Wang,
    X. (2018). A biochemical network controlling basal myosin oscillation. <i>Nature
    Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-018-03574-5">https://doi.org/10.1038/s41467-018-03574-5</a>
  chicago: Qin, Xiang, Edouard B Hannezo, Thomas Mangeat, Chang Liu, Pralay Majumder,
    Jjiaying Liu, Valerie Choesmel Cadamuro, et al. “A Biochemical Network Controlling
    Basal Myosin Oscillation.” <i>Nature Communications</i>. Nature Publishing Group,
    2018. <a href="https://doi.org/10.1038/s41467-018-03574-5">https://doi.org/10.1038/s41467-018-03574-5</a>.
  ieee: X. Qin <i>et al.</i>, “A biochemical network controlling basal myosin oscillation,”
    <i>Nature Communications</i>, vol. 9, no. 1. Nature Publishing Group, 2018.
  ista: Qin X, Hannezo EB, Mangeat T, Liu C, Majumder P, Liu J, Choesmel Cadamuro
    V, Mcdonald J, Liu Y, Yi B, Wang X. 2018. A biochemical network controlling basal
    myosin oscillation. Nature Communications. 9(1), 1210.
  mla: Qin, Xiang, et al. “A Biochemical Network Controlling Basal Myosin Oscillation.”
    <i>Nature Communications</i>, vol. 9, no. 1, 1210, Nature Publishing Group, 2018,
    doi:<a href="https://doi.org/10.1038/s41467-018-03574-5">10.1038/s41467-018-03574-5</a>.
  short: X. Qin, E.B. Hannezo, T. Mangeat, C. Liu, P. Majumder, J. Liu, V. Choesmel
    Cadamuro, J. Mcdonald, Y. Liu, B. Yi, X. Wang, Nature Communications 9 (2018).
date_created: 2018-12-11T11:46:16Z
date_published: 2018-03-23T00:00:00Z
date_updated: 2023-09-08T11:41:45Z
day: '23'
ddc:
- '539'
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-018-03574-5
external_id:
  isi:
  - '000428165400009'
file:
- access_level: open_access
  checksum: 87a427bc2e8724be3dd22a4efdd21a33
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:45Z
  date_updated: 2020-07-14T12:46:22Z
  file_id: '4902'
  file_name: IST-2018-996-v1+1_2018_Hannezo_A-biochemical.pdf
  file_size: 3780491
  relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '7427'
pubrep_id: '996'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A biochemical network controlling basal myosin oscillation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2018'
...
---
_id: '421'
abstract:
- lang: eng
  text: Cell shape is determined by a balance of intrinsic properties of the cell
    as well as its mechanochemical environment. Inhomogeneous shape changes underlie
    many morphogenetic events and involve spatial gradients in active cellular forces
    induced by complex chemical signaling. Here, we introduce a mechanochemical model
    based on the notion that cell shape changes may be induced by external diffusible
    biomolecules that influence cellular contractility (or equivalently, adhesions)
    in a concentration-dependent manner—and whose spatial profile in turn is affected
    by cell shape. We map out theoretically the possible interplay between chemical
    concentration and cellular structure. Besides providing a direct route to spatial
    gradients in cell shape profiles in tissues, we show that the dependence on cell
    shape helps create robust mechanochemical gradients.
article_processing_charge: No
arxiv: 1
author:
- first_name: Kinjal
  full_name: Dasbiswas, Kinjal
  last_name: Dasbiswas
- first_name: Claude-Edouard B
  full_name: Hannezo, Claude-Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Nir
  full_name: Gov, Nir
  last_name: Gov
citation:
  ama: Dasbiswas K, Hannezo EB, Gov N. Theory of eppithelial cell shape transitions
    induced by mechanoactive chemical gradients. <i>Biophysical Journal</i>. 2018;114(4):968-977.
    doi:<a href="https://doi.org/10.1016/j.bpj.2017.12.022">10.1016/j.bpj.2017.12.022</a>
  apa: Dasbiswas, K., Hannezo, E. B., &#38; Gov, N. (2018). Theory of eppithelial
    cell shape transitions induced by mechanoactive chemical gradients. <i>Biophysical
    Journal</i>. Biophysical Society. <a href="https://doi.org/10.1016/j.bpj.2017.12.022">https://doi.org/10.1016/j.bpj.2017.12.022</a>
  chicago: Dasbiswas, Kinjal, Edouard B Hannezo, and Nir Gov. “Theory of Eppithelial
    Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.” <i>Biophysical
    Journal</i>. Biophysical Society, 2018. <a href="https://doi.org/10.1016/j.bpj.2017.12.022">https://doi.org/10.1016/j.bpj.2017.12.022</a>.
  ieee: K. Dasbiswas, E. B. Hannezo, and N. Gov, “Theory of eppithelial cell shape
    transitions induced by mechanoactive chemical gradients,” <i>Biophysical Journal</i>,
    vol. 114, no. 4. Biophysical Society, pp. 968–977, 2018.
  ista: Dasbiswas K, Hannezo EB, Gov N. 2018. Theory of eppithelial cell shape transitions
    induced by mechanoactive chemical gradients. Biophysical Journal. 114(4), 968–977.
  mla: Dasbiswas, Kinjal, et al. “Theory of Eppithelial Cell Shape Transitions Induced
    by Mechanoactive Chemical Gradients.” <i>Biophysical Journal</i>, vol. 114, no.
    4, Biophysical Society, 2018, pp. 968–77, doi:<a href="https://doi.org/10.1016/j.bpj.2017.12.022">10.1016/j.bpj.2017.12.022</a>.
  short: K. Dasbiswas, E.B. Hannezo, N. Gov, Biophysical Journal 114 (2018) 968–977.
date_created: 2018-12-11T11:46:23Z
date_published: 2018-02-27T00:00:00Z
date_updated: 2023-09-19T10:13:55Z
day: '27'
department:
- _id: EdHa
doi: 10.1016/j.bpj.2017.12.022
external_id:
  arxiv:
  - '1709.01486'
  isi:
  - '000428016700021'
intvolume: '       114'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1709.01486
month: '02'
oa: 1
oa_version: Submitted Version
page: 968 - 977
publication: Biophysical Journal
publication_status: published
publisher: Biophysical Society
publist_id: '7403'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Theory of eppithelial cell shape transitions induced by mechanoactive chemical
  gradients
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 114
year: '2018'
...
---
_id: '3'
abstract:
- lang: eng
  text: SETD5 gene mutations have been identified as a frequent cause of idiopathic
    intellectual disability. Here we show that Setd5-haploinsufficient mice present
    developmental defects such as abnormal brain-to-body weight ratios and neural
    crest defect-associated phenotypes. Furthermore, Setd5-mutant mice show impairments
    in cognitive tasks, enhanced long-term potentiation, delayed ontogenetic profile
    of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are
    accompanied by abnormal expression of postsynaptic density proteins previously
    associated with cognition. Our data additionally indicate that Setd5 regulates
    RNA polymerase II dynamics and gene transcription via its interaction with the
    Hdac3 and Paf1 complexes, findings potentially explaining the gene expression
    defects observed in Setd5-haploinsufficient mice. Our results emphasize the decisive
    role of Setd5 in a biological pathway found to be disrupted in humans with intellectual
    disability and autism spectrum disorder.
acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
acknowledgement: This work was supported by the Simons Foundation Autism Research
  Initiative (grant 401299) to G.N. and the DFG (SPP1738 grant NO 1249) to K.-M.N.
article_processing_charge: No
article_type: original
author:
- first_name: Elena
  full_name: Deliu, Elena
  id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
  last_name: Deliu
  orcid: 0000-0002-7370-5293
- first_name: Niccoló
  full_name: Arecco, Niccoló
  last_name: Arecco
- first_name: Jasmin
  full_name: Morandell, Jasmin
  id: 4739D480-F248-11E8-B48F-1D18A9856A87
  last_name: Morandell
- first_name: Christoph
  full_name: Dotter, Christoph
  id: 4C66542E-F248-11E8-B48F-1D18A9856A87
  last_name: Dotter
  orcid: 0000-0002-9033-9096
- first_name: Ximena
  full_name: Contreras, Ximena
  id: 475990FE-F248-11E8-B48F-1D18A9856A87
  last_name: Contreras
- first_name: Charles
  full_name: Girardot, Charles
  last_name: Girardot
- first_name: Eva
  full_name: Käsper, Eva
  last_name: Käsper
- first_name: Alena
  full_name: Kozlova, Alena
  id: C50A9596-02D0-11E9-976E-E38CFE5CBC1D
  last_name: Kozlova
- first_name: Kasumi
  full_name: Kishi, Kasumi
  id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
  last_name: Kishi
  orcid: 0000-0001-6060-4795
- first_name: Ilaria
  full_name: Chiaradia, Ilaria
  id: B6467F20-02D0-11E9-BDA5-E960C241894A
  last_name: Chiaradia
  orcid: 0000-0002-9529-4464
- first_name: Kyung
  full_name: Noh, Kyung
  last_name: Noh
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Deliu E, Arecco N, Morandell J, et al. Haploinsufficiency of the intellectual
    disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature
    Neuroscience</i>. 2018;21(12):1717-1727. doi:<a href="https://doi.org/10.1038/s41593-018-0266-2">10.1038/s41593-018-0266-2</a>
  apa: Deliu, E., Arecco, N., Morandell, J., Dotter, C., Contreras, X., Girardot,
    C., … Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene
    SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/s41593-018-0266-2">https://doi.org/10.1038/s41593-018-0266-2</a>
  chicago: Deliu, Elena, Niccoló Arecco, Jasmin Morandell, Christoph Dotter, Ximena
    Contreras, Charles Girardot, Eva Käsper, et al. “Haploinsufficiency of the Intellectual
    Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature
    Neuroscience</i>. Nature Publishing Group, 2018. <a href="https://doi.org/10.1038/s41593-018-0266-2">https://doi.org/10.1038/s41593-018-0266-2</a>.
  ieee: E. Deliu <i>et al.</i>, “Haploinsufficiency of the intellectual disability
    gene SETD5 disturbs developmental gene expression and cognition,” <i>Nature Neuroscience</i>,
    vol. 21, no. 12. Nature Publishing Group, pp. 1717–1727, 2018.
  ista: Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, Käsper
    E, Kozlova A, Kishi K, Chiaradia I, Noh K, Novarino G. 2018. Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition. Nature Neuroscience. 21(12), 1717–1727.
  mla: Deliu, Elena, et al. “Haploinsufficiency of the Intellectual Disability Gene
    SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>,
    vol. 21, no. 12, Nature Publishing Group, 2018, pp. 1717–27, doi:<a href="https://doi.org/10.1038/s41593-018-0266-2">10.1038/s41593-018-0266-2</a>.
  short: E. Deliu, N. Arecco, J. Morandell, C. Dotter, X. Contreras, C. Girardot,
    E. Käsper, A. Kozlova, K. Kishi, I. Chiaradia, K. Noh, G. Novarino, Nature Neuroscience
    21 (2018) 1717–1727.
corr_author: '1'
date_created: 2018-12-11T11:44:05Z
date_published: 2018-11-19T00:00:00Z
date_updated: 2026-05-20T22:30:37Z
day: '19'
ddc:
- '570'
department:
- _id: GaNo
- _id: EdHa
doi: 10.1038/s41593-018-0266-2
external_id:
  isi:
  - '000451324700010'
file:
- access_level: open_access
  checksum: 60abd0f05b7cdc08a6b0ec460884084f
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-09T07:41:57Z
  date_updated: 2020-07-14T12:45:58Z
  file_id: '6255'
  file_name: 2017_NatureNeuroscience_Deliu.pdf
  file_size: 8167169
  relation: main_file
file_date_updated: 2020-07-14T12:45:58Z
has_accepted_license: '1'
intvolume: '        21'
isi: 1
issue: '12'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 1717 - 1727
project:
- _id: 254BA948-B435-11E9-9278-68D0E5697425
  grant_number: '401299'
  name: Probing development and reversibility of autism spectrum disorders
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '8054'
pubrep_id: '1071'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/mutation-that-causes-autism-and-intellectual-disability-makes-brain-less-flexible/
  record:
  - id: '6074'
    relation: popular_science
    status: public
  - id: '12364'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental
  gene expression and cognition
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 21
year: '2018'
...
---
_id: '726'
abstract:
- lang: eng
  text: The morphogenesis of branched organs remains a subject of abiding interest.
    Although much is known about the underlying signaling pathways, it remains unclear
    how macroscopic features of branched organs, including their size, network topology,
    and spatial patterning, are encoded. Here, we show that, in mouse mammary gland,
    kidney, and human prostate, these features can be explained quantitatively within
    a single unifying framework of branching and annihilating random walks. Based
    on quantitative analyses of large-scale organ reconstructions and proliferation
    kinetics measurements, we propose that morphogenesis follows from the proliferative
    activity of equipotent tips that stochastically branch and randomly explore their
    environment but compete neutrally for space, becoming proliferatively inactive
    when in proximity with neighboring ducts. These results show that complex branched
    epithelial structures develop as a self-organized process, reliant upon a strikingly
    simple but generic rule, without recourse to a rigid and deterministic sequence
    of genetically programmed events.
article_processing_charge: No
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Colinda
  full_name: Scheele, Colinda
  last_name: Scheele
- first_name: Mohammad
  full_name: Moad, Mohammad
  last_name: Moad
- first_name: Nicholas
  full_name: Drogo, Nicholas
  last_name: Drogo
- first_name: Rakesh
  full_name: Heer, Rakesh
  last_name: Heer
- first_name: Rosemary
  full_name: Sampogna, Rosemary
  last_name: Sampogna
- first_name: Jacco
  full_name: Van Rheenen, Jacco
  last_name: Van Rheenen
- first_name: Benjamin
  full_name: Simons, Benjamin
  last_name: Simons
citation:
  ama: Hannezo EB, Scheele C, Moad M, et al. A unifying theory of branching morphogenesis.
    <i>Cell</i>. 2017;171(1):242-255. doi:<a href="https://doi.org/10.1016/j.cell.2017.08.026">10.1016/j.cell.2017.08.026</a>
  apa: Hannezo, E. B., Scheele, C., Moad, M., Drogo, N., Heer, R., Sampogna, R., …
    Simons, B. (2017). A unifying theory of branching morphogenesis. <i>Cell</i>.
    Cell Press. <a href="https://doi.org/10.1016/j.cell.2017.08.026">https://doi.org/10.1016/j.cell.2017.08.026</a>
  chicago: Hannezo, Edouard B, Colinda Scheele, Mohammad Moad, Nicholas Drogo, Rakesh
    Heer, Rosemary Sampogna, Jacco Van Rheenen, and Benjamin Simons. “A Unifying Theory
    of Branching Morphogenesis.” <i>Cell</i>. Cell Press, 2017. <a href="https://doi.org/10.1016/j.cell.2017.08.026">https://doi.org/10.1016/j.cell.2017.08.026</a>.
  ieee: E. B. Hannezo <i>et al.</i>, “A unifying theory of branching morphogenesis,”
    <i>Cell</i>, vol. 171, no. 1. Cell Press, pp. 242–255, 2017.
  ista: Hannezo EB, Scheele C, Moad M, Drogo N, Heer R, Sampogna R, Van Rheenen J,
    Simons B. 2017. A unifying theory of branching morphogenesis. Cell. 171(1), 242–255.
  mla: Hannezo, Edouard B., et al. “A Unifying Theory of Branching Morphogenesis.”
    <i>Cell</i>, vol. 171, no. 1, Cell Press, 2017, pp. 242–55, doi:<a href="https://doi.org/10.1016/j.cell.2017.08.026">10.1016/j.cell.2017.08.026</a>.
  short: E.B. Hannezo, C. Scheele, M. Moad, N. Drogo, R. Heer, R. Sampogna, J. Van
    Rheenen, B. Simons, Cell 171 (2017) 242–255.
corr_author: '1'
date_created: 2018-12-11T11:48:10Z
date_published: 2017-09-21T00:00:00Z
date_updated: 2025-07-10T11:54:27Z
day: '21'
ddc:
- '539'
department:
- _id: EdHa
doi: 10.1016/j.cell.2017.08.026
external_id:
  isi:
  - '000411331800024'
file:
- access_level: open_access
  checksum: 7a036d93a9e2e597af9bb504d6133aca
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:17Z
  date_updated: 2020-07-14T12:47:55Z
  file_id: '4870'
  file_name: IST-2017-883-v1+1_PIIS0092867417309510.pdf
  file_size: 12670204
  relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: '       171'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 242 - 255
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '6952'
pubrep_id: '883'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A unifying theory of branching morphogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 171
year: '2017'
...