---
OA_place: publisher
_id: '8934'
abstract:
- lang: eng
  text: "In this thesis, we consider several of the most classical and fundamental
    problems in static analysis and formal verification, including invariant generation,
    reachability analysis, termination analysis of probabilistic programs, data-flow
    analysis, quantitative analysis of Markov chains and Markov decision processes,
    and the problem of data packing in cache management.\r\nWe use techniques from
    parameterized complexity theory, polyhedral geometry, and real algebraic geometry
    to significantly improve the state-of-the-art, in terms of both scalability and
    completeness guarantees, for the mentioned problems. In some cases, our results
    are the first theoretical improvements for the respective problems in two or three
    decades."
acknowledgement: 'The research was partially supported by an IBM PhD fellowship, a
  Facebook PhD fellowship, and DOC fellowship #24956 of the Austrian Academy of Sciences
  (OeAW).'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Amir Kafshdar
  full_name: Goharshady, Amir Kafshdar
  id: 391365CE-F248-11E8-B48F-1D18A9856A87
  last_name: Goharshady
  orcid: 0000-0003-1702-6584
citation:
  ama: Goharshady AK. Parameterized and algebro-geometric advances in static program
    analysis. 2021. doi:<a href="https://doi.org/10.15479/AT:ISTA:8934">10.15479/AT:ISTA:8934</a>
  apa: Goharshady, A. K. (2021). <i>Parameterized and algebro-geometric advances in
    static program analysis</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:8934">https://doi.org/10.15479/AT:ISTA:8934</a>
  chicago: Goharshady, Amir Kafshdar. “Parameterized and Algebro-Geometric Advances
    in Static Program Analysis.” Institute of Science and Technology Austria, 2021.
    <a href="https://doi.org/10.15479/AT:ISTA:8934">https://doi.org/10.15479/AT:ISTA:8934</a>.
  ieee: A. K. Goharshady, “Parameterized and algebro-geometric advances in static
    program analysis,” Institute of Science and Technology Austria, 2021.
  ista: Goharshady AK. 2021. Parameterized and algebro-geometric advances in static
    program analysis. Institute of Science and Technology Austria.
  mla: Goharshady, Amir Kafshdar. <i>Parameterized and Algebro-Geometric Advances
    in Static Program Analysis</i>. Institute of Science and Technology Austria, 2021,
    doi:<a href="https://doi.org/10.15479/AT:ISTA:8934">10.15479/AT:ISTA:8934</a>.
  short: A.K. Goharshady, Parameterized and Algebro-Geometric Advances in Static Program
    Analysis, Institute of Science and Technology Austria, 2021.
corr_author: '1'
date_created: 2020-12-10T12:17:07Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2026-04-16T10:07:18Z
day: '01'
ddc:
- '005'
degree_awarded: PhD
department:
- _id: KrCh
- _id: GradSch
doi: 10.15479/AT:ISTA:8934
file:
- access_level: open_access
  checksum: d1b9db3725aed34dadd81274aeb9426c
  content_type: application/pdf
  creator: akafshda
  date_created: 2020-12-22T20:08:44Z
  date_updated: 2021-12-23T23:30:04Z
  embargo: 2021-12-22
  file_id: '8969'
  file_name: Thesis-pdfa.pdf
  file_size: 5251507
  relation: main_file
- access_level: closed
  checksum: 1661df7b393e6866d2460eba3c905130
  content_type: application/zip
  creator: akafshda
  date_created: 2020-12-22T20:08:50Z
  date_updated: 2021-03-04T23:30:04Z
  embargo_to: open_access
  file_id: '8970'
  file_name: source.zip
  file_size: 10636756
  relation: source_file
file_date_updated: 2021-12-23T23:30:04Z
fulldoi: https://doi.org/10.15479/AT:ISTA:8934
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '01'
oa: 1
oa_version: Published Version
page: '278'
project:
- _id: 267066CE-B435-11E9-9278-68D0E5697425
  name: Quantitative Analysis of Probabilistic Systems with a focus on Crypto-Currencies
- _id: 266EEEC0-B435-11E9-9278-68D0E5697425
  name: Quantitative Game-theoretic Analysis of Blockchain Applications and Smart
    Contracts
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6490'
    relation: part_of_dissertation
    status: public
  - id: '6780'
    relation: part_of_dissertation
    status: public
  - id: '7158'
    relation: part_of_dissertation
    status: public
  - id: '66'
    relation: part_of_dissertation
    status: public
  - id: '6378'
    relation: part_of_dissertation
    status: public
  - id: '311'
    relation: part_of_dissertation
    status: public
  - id: '6175'
    relation: part_of_dissertation
    status: public
  - id: '6340'
    relation: part_of_dissertation
    status: public
  - id: '7014'
    relation: part_of_dissertation
    status: public
  - id: '6009'
    relation: part_of_dissertation
    status: public
  - id: '1437'
    relation: part_of_dissertation
    status: public
  - id: '8728'
    relation: part_of_dissertation
    status: public
  - id: '8089'
    relation: part_of_dissertation
    status: public
  - id: '6380'
    relation: part_of_dissertation
    status: public
  - id: '5977'
    relation: part_of_dissertation
    status: public
  - id: '6056'
    relation: part_of_dissertation
    status: public
  - id: '639'
    relation: part_of_dissertation
    status: public
  - id: '1386'
    relation: part_of_dissertation
    status: public
  - id: '6918'
    relation: part_of_dissertation
    status: public
  - id: '7810'
    relation: part_of_dissertation
    status: public
  - id: '949'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
title: Parameterized and algebro-geometric advances in static program analysis
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2021'
...
---
OA_place: publisher
_id: '9962'
abstract:
- lang: eng
  text: The brain is one of the largest and most complex organs and it is composed
    of billions of neurons that communicate together enabling e.g. consciousness.
    The cerebral cortex is the largest site of neural integration in the central nervous
    system. Concerted radial migration of newly born cortical projection neurons,
    from their birthplace to their final position, is a key step in the assembly of
    the cerebral cortex. The cellular and molecular mechanisms regulating radial neuronal
    migration in vivo are however still unclear. Recent evidence suggests that distinct
    signaling cues act cell-autonomously but differentially at certain steps during
    the overall migration process. Moreover, functional analysis of genetic mosaics
    (mutant neurons present in wild-type/heterozygote environment) using the MADM
    (Mosaic Analysis with Double Markers) analyses in comparison to global knockout
    also indicate a significant degree of non-cell-autonomous and/or community effects
    in the control of cortical neuron migration. The interactions of cell-intrinsic
    (cell-autonomous) and cell-extrinsic (non-cell-autonomous) components are largely
    unknown. In part of this thesis work we established a MADM-based experimental
    strategy for the quantitative analysis of cell-autonomous gene function versus
    non-cell-autonomous and/or community effects. The direct comparison of mutant
    neurons from the genetic mosaic (cell-autonomous) to mutant neurons in the conditional
    and/or global knockout (cell-autonomous + non-cell-autonomous) allows to quantitatively
    analyze non-cell-autonomous effects. Such analysis enable the high-resolution
    analysis of projection neuron migration dynamics in distinct environments with
    concomitant isolation of genomic and proteomic profiles. Using these experimental
    paradigms and in combination with computational modeling we show and characterize
    the nature of non-cell-autonomous effects to coordinate radial neuron migration.
    Furthermore, this thesis discusses recent developments in neurodevelopment with
    focus on neuronal polarization and non-cell-autonomous mechanisms in neuronal
    migration.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Andi H
  full_name: Hansen, Andi H
  id: 38853E16-F248-11E8-B48F-1D18A9856A87
  last_name: Hansen
citation:
  ama: Hansen AH. Cell-autonomous gene function and non-cell-autonomous effects in
    radial projection neuron migration. 2021. doi:<a href="https://doi.org/10.15479/at:ista:9962">10.15479/at:ista:9962</a>
  apa: Hansen, A. H. (2021). <i>Cell-autonomous gene function and non-cell-autonomous
    effects in radial projection neuron migration</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:9962">https://doi.org/10.15479/at:ista:9962</a>
  chicago: Hansen, Andi H. “Cell-Autonomous Gene Function and Non-Cell-Autonomous
    Effects in Radial Projection Neuron Migration.” Institute of Science and Technology
    Austria, 2021. <a href="https://doi.org/10.15479/at:ista:9962">https://doi.org/10.15479/at:ista:9962</a>.
  ieee: A. H. Hansen, “Cell-autonomous gene function and non-cell-autonomous effects
    in radial projection neuron migration,” Institute of Science and Technology Austria,
    2021.
  ista: Hansen AH. 2021. Cell-autonomous gene function and non-cell-autonomous effects
    in radial projection neuron migration. Institute of Science and Technology Austria.
  mla: Hansen, Andi H. <i>Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects
    in Radial Projection Neuron Migration</i>. Institute of Science and Technology
    Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:9962">10.15479/at:ista:9962</a>.
  short: A.H. Hansen, Cell-Autonomous Gene Function and Non-Cell-Autonomous Effects
    in Radial Projection Neuron Migration, Institute of Science and Technology Austria,
    2021.
corr_author: '1'
date_created: 2021-08-29T12:36:50Z
date_published: 2021-09-02T00:00:00Z
date_updated: 2026-04-08T07:19:09Z
day: '02'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SiHi
doi: 10.15479/at:ista:9962
file:
- access_level: closed
  checksum: 66b56f5b988b233dc66a4f4b4fb2cdfe
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: ahansen
  date_created: 2021-08-30T09:17:39Z
  date_updated: 2022-09-03T22:30:04Z
  embargo_to: open_access
  file_id: '9971'
  file_name: Thesis_Hansen.docx
  file_size: 10629190
  relation: source_file
- access_level: open_access
  checksum: 204fa40321a1c6289b68c473634c4bf3
  content_type: application/pdf
  creator: ahansen
  date_created: 2021-08-30T09:29:44Z
  date_updated: 2022-09-03T22:30:04Z
  embargo: 2022-09-02
  file_id: '9972'
  file_name: Thesis_Hansen_PDFA-1a.pdf
  file_size: 13457469
  relation: main_file
file_date_updated: 2022-09-03T22:30:04Z
fulldoi: https://doi.org/10.15479/at:ista:9962
has_accepted_license: '1'
keyword:
- Neuronal migration
- Non-cell-autonomous
- Cell-autonomous
- Neurodevelopmental disease
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '182'
project:
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
  grant_number: '24812'
  name: Molecular mechanisms of radial neuronal migration
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '8569'
    relation: part_of_dissertation
    status: public
  - id: '960'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
title: Cell-autonomous gene function and non-cell-autonomous effects in radial projection
  neuron migration
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2021'
...
---
OA_place: publisher
_id: '9562'
abstract:
- lang: eng
  text: Left-right asymmetries can be considered a fundamental organizational principle
    of the vertebrate central nervous system. The hippocampal CA3-CA1 pyramidal cell
    synaptic connection shows an input-side dependent asymmetry where the hemispheric
    location of the presynaptic CA3 neuron determines the synaptic properties. Left-input
    synapses terminating on apical dendrites in stratum radiatum have a higher density
    of NMDA receptor subunit GluN2B, a lower density of AMPA receptor subunit GluA1
    and smaller areas with less often perforated PSDs. On the other hand, left-input
    synapses terminating on basal dendrites in stratum oriens have lower GluN2B densities
    than right-input ones. Apical and basal synapses further employ different signaling
    pathways involved in LTP. SDS-digested freeze-fracture replica labeling can visualize
    synaptic membrane proteins with high sensitivity and resolution, and has been
    used to reveal the asymmetry at the electron microscopic level. However, it requires
    time-consuming manual demarcation of the synaptic surface for quantitative measurements.
    To facilitate the analysis of replica labeling, I first developed a software named
    Darea, which utilizes deep-learning to automatize this demarcation. With Darea
    I characterized the synaptic distribution of NMDA and AMPA receptors as well as
    the voltage-gated Ca2+ channels in CA1 stratum radiatum and oriens. Second, I
    explored the role of GluN2B and its carboxy-terminus in the establishment of input-side
    dependent hippocampal asymmetry. In conditional knock-out mice lacking GluN2B
    expression in CA1 and GluN2B-2A swap mice, where GluN2B carboxy-terminus was exchanged
    to that of GluN2A, no significant asymmetries of GluN2B, GluA1 and PSD area were
    detected. We further discovered a previously unknown functional asymmetry of GluN2A,
    which was also lost in the swap mouse. These results demonstrate that GluN2B carboxy-terminus
    plays a critical role in normal formation of input-side dependent asymmetry.
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: David
  full_name: Kleindienst, David
  id: 42E121A4-F248-11E8-B48F-1D18A9856A87
  last_name: Kleindienst
citation:
  ama: 'Kleindienst D. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor
    subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning.
    2021. doi:<a href="https://doi.org/10.15479/at:ista:9562">10.15479/at:ista:9562</a>'
  apa: 'Kleindienst, D. (2021). <i>2B or not 2B: Hippocampal asymmetries mediated
    by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis
    by Deep-Learning</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:9562">https://doi.org/10.15479/at:ista:9562</a>'
  chicago: 'Kleindienst, David. “2B or Not 2B: Hippocampal Asymmetries Mediated by
    NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by
    Deep-Learning.” Institute of Science and Technology Austria, 2021. <a href="https://doi.org/10.15479/at:ista:9562">https://doi.org/10.15479/at:ista:9562</a>.'
  ieee: 'D. Kleindienst, “2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor
    subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning,”
    Institute of Science and Technology Austria, 2021.'
  ista: 'Kleindienst D. 2021. 2B or not 2B: Hippocampal asymmetries mediated by NMDA
    receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning.
    Institute of Science and Technology Austria.'
  mla: 'Kleindienst, David. <i>2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA
    Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning</i>.
    Institute of Science and Technology Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:9562">10.15479/at:ista:9562</a>.'
  short: 'D. Kleindienst, 2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor
    Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning,
    Institute of Science and Technology Austria, 2021.'
corr_author: '1'
date_created: 2021-06-17T14:10:47Z
date_published: 2021-06-01T00:00:00Z
date_updated: 2026-07-06T13:11:44Z
day: '01'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RySh
doi: 10.15479/at:ista:9562
file:
- access_level: open_access
  checksum: 659df5518db495f679cb1df9e9bd1d94
  content_type: application/pdf
  creator: dkleindienst
  date_created: 2021-06-17T14:03:14Z
  date_updated: 2022-07-02T22:30:04Z
  embargo: 2022-07-01
  file_id: '9563'
  file_name: Thesis.pdf
  file_size: 77299142
  relation: main_file
- access_level: closed
  checksum: 3bcf63a2b19e5b6663be051bea332748
  content_type: application/zip
  creator: dkleindienst
  date_created: 2021-06-17T14:04:30Z
  date_updated: 2022-07-02T22:30:04Z
  embargo_to: open_access
  file_id: '9564'
  file_name: Thesis_source.zip
  file_size: 369804895
  relation: source_file
file_date_updated: 2022-07-02T22:30:04Z
fulldoi: https://doi.org/10.15479/at:ista:9562
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '124'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9437'
    relation: part_of_dissertation
    status: public
  - id: '612'
    relation: part_of_dissertation
    status: public
  - id: '8532'
    relation: part_of_dissertation
    status: public
  - id: '9756'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
title: '2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B
  C-terminus and high-throughput image analysis by Deep-Learning'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2021'
...
---
_id: '9760'
abstract:
- lang: eng
  text: "The quantum approximate optimization algorithm (QAOA) is a prospective near-term
    quantum algorithm due to its modest circuit depth and promising benchmarks. However,
    an external parameter optimization required in the QAOA could become a performance
    bottleneck. This motivates studies of the optimization landscape and search for
    heuristic ways of parameter initialization. In this work we visualize the optimization
    landscape of the QAOA applied to the MaxCut problem on random graphs, demonstrating
    that random initialization of the QAOA is prone to converging to local minima
    with suboptimal performance. We introduce the initialization of QAOA parameters
    based on the Trotterized quantum annealing (TQA) protocol, parameterized by the
    Trotter time step. We find that the TQA initialization allows to circumvent\r\nthe
    issue of false minima for a broad range of time steps, yielding the same performance
    as the best result out of an exponentially scaling number of random initializations.
    Moreover, we demonstrate that the optimal value of the time step coincides with
    the point of proliferation of Trotter errors in quantum annealing. Our results
    suggest practical ways of initializing QAOA protocols on near-term quantum devices
    and reveal new connections between QAOA and quantum annealing."
acknowledgement: We would like to thank D. Abanin and R. Medina for fruitful discussions
  and A. Smith and I. Kim for valuable feedback on the manuscript. We acknowledge
  support by the European Research Council (ERC) under the European Union’s Horizon
  2020 research and innovation program (Grant Agreement No. 850899).
article_number: '491'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Stefan
  full_name: Sack, Stefan
  id: dd622248-f6e0-11ea-865d-ce382a1c81a5
  last_name: Sack
  orcid: 0000-0001-5400-8508
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Sack S, Serbyn M. Quantum annealing initialization of the quantum approximate
    optimization algorithm. <i>Quantum</i>. 2021;5. doi:<a href="https://doi.org/10.22331/Q-2021-07-01-491">10.22331/Q-2021-07-01-491</a>
  apa: Sack, S., &#38; Serbyn, M. (2021). Quantum annealing initialization of the
    quantum approximate optimization algorithm. <i>Quantum</i>. Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften. <a href="https://doi.org/10.22331/Q-2021-07-01-491">https://doi.org/10.22331/Q-2021-07-01-491</a>
  chicago: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the
    Quantum Approximate Optimization Algorithm.” <i>Quantum</i>. Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften, 2021. <a href="https://doi.org/10.22331/Q-2021-07-01-491">https://doi.org/10.22331/Q-2021-07-01-491</a>.
  ieee: S. Sack and M. Serbyn, “Quantum annealing initialization of the quantum approximate
    optimization algorithm,” <i>Quantum</i>, vol. 5. Verein zur Förderung des Open
    Access Publizierens in den Quantenwissenschaften, 2021.
  ista: Sack S, Serbyn M. 2021. Quantum annealing initialization of the quantum approximate
    optimization algorithm. Quantum. 5, 491.
  mla: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum
    Approximate Optimization Algorithm.” <i>Quantum</i>, vol. 5, 491, Verein zur Förderung
    des Open Access Publizierens in den Quantenwissenschaften, 2021, doi:<a href="https://doi.org/10.22331/Q-2021-07-01-491">10.22331/Q-2021-07-01-491</a>.
  short: S. Sack, M. Serbyn, Quantum 5 (2021).
corr_author: '1'
date_created: 2021-08-01T22:01:21Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2026-10-13T22:31:13Z
day: '01'
ddc:
- '530'
department:
- _id: GradSch
- _id: MaSe
doi: 10.22331/Q-2021-07-01-491
ec_funded: 1
external_id:
  arxiv:
  - '2101.05742'
  isi:
  - '000669830600001'
file:
- access_level: open_access
  checksum: 9706c2bb8e748e9b5b138381995a7f6f
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-08-06T06:44:31Z
  date_updated: 2021-08-06T06:44:31Z
  file_id: '9774'
  file_name: 2021_Quantum_Sack.pdf
  file_size: 2312482
  relation: main_file
file_date_updated: 2021-08-06T06:44:31Z
fulldoi: https://doi.org/10.22331/Q-2021-07-01-491
has_accepted_license: '1'
intvolume: '         5'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Quantum
publication_identifier:
  eissn:
  - 2521-327X
publication_status: published
publisher: Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften
quality_controlled: '1'
related_material:
  record:
  - id: '14622'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Quantum annealing initialization of the quantum approximate optimization algorithm
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...
---
_id: '10672'
abstract:
- lang: eng
  text: The family of feedback alignment (FA) algorithms aims to provide a more biologically
    motivated alternative to backpropagation (BP), by substituting the computations
    that are unrealistic to be implemented in physical brains. While FA algorithms
    have been shown to work well in practice, there is a lack of rigorous theory proofing
    their learning capabilities. Here we introduce the first feedback alignment algorithm
    with provable learning guarantees. In contrast to existing work, we do not require
    any assumption about the size or depth of the network except that it has a single
    output neuron, i.e., such as for binary classification tasks. We show that our
    FA algorithm can deliver its theoretical promises in practice, surpassing the
    learning performance of existing FA methods and matching backpropagation in binary
    classification tasks. Finally, we demonstrate the limits of our FA variant when
    the number of output neurons grows beyond a certain quantity.
acknowledgement: "This research was supported in part by the Austrian Science Fund
  (FWF) under grant Z211-N23\r\n(Wittgenstein Award).\r\n"
article_processing_charge: No
author:
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
citation:
  ama: 'Lechner M. Learning representations for binary-classification without backpropagation.
    In: <i>8th International Conference on Learning Representations</i>. ICLR; 2020.'
  apa: 'Lechner, M. (2020). Learning representations for binary-classification without
    backpropagation. In <i>8th International Conference on Learning Representations</i>.
    Virtual ; Addis Ababa, Ethiopia: ICLR.'
  chicago: Lechner, Mathias. “Learning Representations for Binary-Classification without
    Backpropagation.” In <i>8th International Conference on Learning Representations</i>.
    ICLR, 2020.
  ieee: M. Lechner, “Learning representations for binary-classification without backpropagation,”
    in <i>8th International Conference on Learning Representations</i>, Virtual ;
    Addis Ababa, Ethiopia, 2020.
  ista: 'Lechner M. 2020. Learning representations for binary-classification without
    backpropagation. 8th International Conference on Learning Representations. ICLR:
    International Conference on Learning Representations.'
  mla: Lechner, Mathias. “Learning Representations for Binary-Classification without
    Backpropagation.” <i>8th International Conference on Learning Representations</i>,
    ICLR, 2020.
  short: M. Lechner, in:, 8th International Conference on Learning Representations,
    ICLR, 2020.
conference:
  end_date: 2020-05-01
  location: Virtual ; Addis Ababa, Ethiopia
  name: 'ICLR: International Conference on Learning Representations'
  start_date: 2020-04-26
corr_author: '1'
date_created: 2022-01-25T15:50:00Z
date_published: 2020-03-11T00:00:00Z
date_updated: 2025-04-15T06:25:56Z
day: '11'
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
file:
- access_level: open_access
  checksum: ea13d42dd4541ddb239b6a75821fd6c9
  content_type: application/pdf
  creator: mlechner
  date_created: 2022-01-26T07:35:17Z
  date_updated: 2022-01-26T07:35:17Z
  file_id: '10677'
  file_name: iclr_2020.pdf
  file_size: 249431
  relation: main_file
  success: 1
file_date_updated: 2022-01-26T07:35:17Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/3.0/
main_file_link:
- open_access: '1'
  url: https://openreview.net/forum?id=Bke61krFvS
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
publication: 8th International Conference on Learning Representations
publication_status: published
publisher: ICLR
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning representations for binary-classification without backpropagation
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND
    3.0)
  short: CC BY-NC-ND (3.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '10673'
abstract:
- lang: eng
  text: We propose a neural information processing system obtained by re-purposing
    the function of a biological neural circuit model to govern simulated and real-world
    control tasks. Inspired by the structure of the nervous system of the soil-worm,
    C. elegans, we introduce ordinary neural circuits (ONCs), defined as the model
    of biological neural circuits reparameterized for the control of alternative tasks.
    We first demonstrate that ONCs realize networks with higher maximum flow compared
    to arbitrary wired networks. We then learn instances of ONCs to control a series
    of robotic tasks, including the autonomous parking of a real-world rover robot.
    For reconfiguration of the purpose of the neural circuit, we adopt a search-based
    optimization algorithm. Ordinary neural circuits perform on par and, in some cases,
    significantly surpass the performance of contemporary deep learning models. ONC
    networks are compact, 77% sparser than their counterpart neural controllers, and
    their neural dynamics are fully interpretable at the cell-level.
acknowledgement: "RH and RG are partially supported by Horizon-2020 ECSEL Project
  grant No. 783163 (iDev40), Productive 4.0, and ATBMBFW CPS-IoT Ecosystem. ML was
  supported in part by the Austrian Science Fund (FWF) under grant Z211-N23\r\n(Wittgenstein
  Award). AA is supported by the National Science Foundation (NSF) Graduate Research
  Fellowship\r\nProgram. RH and DR are partially supported by The Boeing Company and
  JP Morgan Chase. This research work is\r\npartially drawn from the PhD dissertation
  of RH.\r\n"
alternative_title:
- PMLR
article_processing_charge: No
author:
- first_name: Ramin
  full_name: Hasani, Ramin
  last_name: Hasani
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Alexander
  full_name: Amini, Alexander
  last_name: Amini
- first_name: Daniela
  full_name: Rus, Daniela
  last_name: Rus
- first_name: Radu
  full_name: Grosu, Radu
  last_name: Grosu
citation:
  ama: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. A natural lottery ticket winner:
    Reinforcement learning with ordinary neural circuits. In: <i>Proceedings of the
    37th International Conference on Machine Learning</i>. PMLR. ; 2020:4082-4093.'
  apa: 'Hasani, R., Lechner, M., Amini, A., Rus, D., &#38; Grosu, R. (2020). A natural
    lottery ticket winner: Reinforcement learning with ordinary neural circuits. In
    <i>Proceedings of the 37th International Conference on Machine Learning</i> (pp.
    4082–4093). Virtual.'
  chicago: 'Hasani, Ramin, Mathias Lechner, Alexander Amini, Daniela Rus, and Radu
    Grosu. “A Natural Lottery Ticket Winner: Reinforcement Learning with Ordinary
    Neural Circuits.” In <i>Proceedings of the 37th International Conference on Machine
    Learning</i>, 4082–93. PMLR, 2020.'
  ieee: 'R. Hasani, M. Lechner, A. Amini, D. Rus, and R. Grosu, “A natural lottery
    ticket winner: Reinforcement learning with ordinary neural circuits,” in <i>Proceedings
    of the 37th International Conference on Machine Learning</i>, Virtual, 2020, pp.
    4082–4093.'
  ista: 'Hasani R, Lechner M, Amini A, Rus D, Grosu R. 2020. A natural lottery ticket
    winner: Reinforcement learning with ordinary neural circuits. Proceedings of the
    37th International Conference on Machine Learning. ML: Machine LearningPMLR, PMLR,
    , 4082–4093.'
  mla: 'Hasani, Ramin, et al. “A Natural Lottery Ticket Winner: Reinforcement Learning
    with Ordinary Neural Circuits.” <i>Proceedings of the 37th International Conference
    on Machine Learning</i>, 2020, pp. 4082–93.'
  short: R. Hasani, M. Lechner, A. Amini, D. Rus, R. Grosu, in:, Proceedings of the
    37th International Conference on Machine Learning, 2020, pp. 4082–4093.
conference:
  end_date: 2020-07-18
  location: Virtual
  name: 'ML: Machine Learning'
  start_date: 2020-07-12
date_created: 2022-01-25T15:50:34Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2025-04-15T06:25:56Z
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
file:
- access_level: open_access
  checksum: c9a4a29161777fc1a89ef451c040e3b1
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-01-26T11:08:51Z
  date_updated: 2022-01-26T11:08:51Z
  file_id: '10691'
  file_name: 2020_PMLR_Hasani.pdf
  file_size: 2329798
  relation: main_file
  success: 1
file_date_updated: 2022-01-26T11:08:51Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://proceedings.mlr.press/v119/hasani20a.html
oa: 1
oa_version: Published Version
page: 4082-4093
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
publication: Proceedings of the 37th International Conference on Machine Learning
publication_identifier:
  issn:
  - 2640-3498
publication_status: published
quality_controlled: '1'
scopus_import: '1'
series_title: PMLR
status: public
title: 'A natural lottery ticket winner: Reinforcement learning with ordinary neural
  circuits'
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND
    3.0)
  short: CC BY-NC-ND (3.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
_id: '9196'
abstract:
- lang: eng
  text: In order to provide a local description of a regular function in a small neighbourhood
    of a point x, it is sufficient by Taylor’s theorem to know the value of the function
    as well as all of its derivatives up to the required order at the point x itself.
    In other words, one could say that a regular function is locally modelled by the
    set of polynomials. The theory of regularity structures due to Hairer generalizes
    this observation and provides an abstract setup, which in the application to singular
    SPDE extends the set of polynomials by functionals constructed from, e.g., white
    noise. In this context, the notion of Taylor polynomials is lifted to the notion
    of so-called modelled distributions. The celebrated reconstruction theorem, which
    in turn was inspired by Gubinelli’s \textit {sewing lemma}, is of paramount importance
    for the theory. It enables one to reconstruct a modelled distribution as a true
    distribution on Rd which is locally approximated by this extended set of models
    or “monomials”. In the original work of Hairer, the error is measured by means
    of Hölder norms. This was then generalized to the whole scale of Besov spaces
    by Hairer and Labbé. It is the aim of this work to adapt the analytic part of
    the theory of regularity structures to the scale of Triebel–Lizorkin spaces.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sebastian
  full_name: Hensel, Sebastian
  id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
  last_name: Hensel
  orcid: 0000-0001-7252-8072
- first_name: Tommaso
  full_name: Rosati, Tommaso
  last_name: Rosati
citation:
  ama: Hensel S, Rosati T. Modelled distributions of Triebel–Lizorkin type. <i>Studia
    Mathematica</i>. 2020;252(3):251-297. doi:<a href="https://doi.org/10.4064/sm180411-11-2">10.4064/sm180411-11-2</a>
  apa: Hensel, S., &#38; Rosati, T. (2020). Modelled distributions of Triebel–Lizorkin
    type. <i>Studia Mathematica</i>. Instytut Matematyczny. <a href="https://doi.org/10.4064/sm180411-11-2">https://doi.org/10.4064/sm180411-11-2</a>
  chicago: Hensel, Sebastian, and Tommaso Rosati. “Modelled Distributions of Triebel–Lizorkin
    Type.” <i>Studia Mathematica</i>. Instytut Matematyczny, 2020. <a href="https://doi.org/10.4064/sm180411-11-2">https://doi.org/10.4064/sm180411-11-2</a>.
  ieee: S. Hensel and T. Rosati, “Modelled distributions of Triebel–Lizorkin type,”
    <i>Studia Mathematica</i>, vol. 252, no. 3. Instytut Matematyczny, pp. 251–297,
    2020.
  ista: Hensel S, Rosati T. 2020. Modelled distributions of Triebel–Lizorkin type.
    Studia Mathematica. 252(3), 251–297.
  mla: Hensel, Sebastian, and Tommaso Rosati. “Modelled Distributions of Triebel–Lizorkin
    Type.” <i>Studia Mathematica</i>, vol. 252, no. 3, Instytut Matematyczny, 2020,
    pp. 251–97, doi:<a href="https://doi.org/10.4064/sm180411-11-2">10.4064/sm180411-11-2</a>.
  short: S. Hensel, T. Rosati, Studia Mathematica 252 (2020) 251–297.
date_created: 2021-02-25T08:55:03Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-06-24T12:07:06Z
day: '01'
department:
- _id: JuFi
- _id: GradSch
doi: 10.4064/sm180411-11-2
external_id:
  arxiv:
  - '1709.05202'
  isi:
  - '000558100500002'
fulldoi: https://doi.org/10.4064/sm180411-11-2
intvolume: '       252'
isi: 1
issue: '3'
keyword:
- General Mathematics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1709.05202
month: '03'
oa: 1
oa_version: Preprint
page: 251-297
publication: Studia Mathematica
publication_identifier:
  eissn:
  - 1730-6337
  issn:
  - 0039-3223
publication_status: published
publisher: Instytut Matematyczny
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modelled distributions of Triebel–Lizorkin type
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 252
year: '2020'
...
---
OA_place: publisher
_id: '7196'
abstract:
- lang: eng
  text: 'In this thesis we study certain mathematical aspects of evolution. The two
    primary forces that drive an evolutionary process are mutation and selection.
    Mutation generates new variants in a population. Selection chooses among the variants
    depending on the reproductive rates of individuals. Evolutionary processes are
    intrinsically random – a new mutation that is initially present in the population
    at low frequency can go extinct, even if it confers a reproductive advantage.
    The overall rate of evolution is largely determined by two quantities: the probability
    that an invading advantageous mutation spreads through the population (called
    fixation probability) and the time until it does so (called fixation time). Both
    those quantities crucially depend not only on the strength of the invading mutation
    but also on the population structure. In this thesis, we aim to understand how
    the underlying population structure affects the overall rate of evolution. Specifically,
    we study population structures that increase the fixation probability of advantageous
    mutants (called amplifiers of selection). Broadly speaking, our results are of
    three different types: We present various strong amplifiers, we identify regimes
    under which only limited amplification is feasible, and we propose population
    structures that provide different tradeoffs between high fixation probability
    and short fixation time.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
citation:
  ama: Tkadlec J. A role of graphs in evolutionary processes. 2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:7196">10.15479/AT:ISTA:7196</a>
  apa: Tkadlec, J. (2020). <i>A role of graphs in evolutionary processes</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:7196">https://doi.org/10.15479/AT:ISTA:7196</a>
  chicago: Tkadlec, Josef. “A Role of Graphs in Evolutionary Processes.” Institute
    of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:7196">https://doi.org/10.15479/AT:ISTA:7196</a>.
  ieee: J. Tkadlec, “A role of graphs in evolutionary processes,” Institute of Science
    and Technology Austria, 2020.
  ista: Tkadlec J. 2020. A role of graphs in evolutionary processes. Institute of
    Science and Technology Austria.
  mla: Tkadlec, Josef. <i>A Role of Graphs in Evolutionary Processes</i>. Institute
    of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:7196">10.15479/AT:ISTA:7196</a>.
  short: J. Tkadlec, A Role of Graphs in Evolutionary Processes, Institute of Science
    and Technology Austria, 2020.
corr_author: '1'
date_created: 2019-12-20T12:26:36Z
date_published: 2020-01-12T00:00:00Z
date_updated: 2026-04-16T08:32:37Z
day: '12'
ddc:
- '519'
degree_awarded: PhD
department:
- _id: KrCh
- _id: GradSch
doi: 10.15479/AT:ISTA:7196
file:
- access_level: closed
  checksum: 451f8e64b0eb26bf297644ac72bfcbe9
  content_type: application/zip
  creator: jtkadlec
  date_created: 2020-01-12T11:49:49Z
  date_updated: 2020-07-14T12:47:52Z
  file_id: '7255'
  file_name: thesis.zip
  file_size: 21100497
  relation: source_file
- access_level: open_access
  checksum: d8c44cbc4f939c49a8efc9d4b8bb3985
  content_type: application/pdf
  creator: dernst
  date_created: 2020-01-28T07:32:42Z
  date_updated: 2020-07-14T12:47:52Z
  file_id: '7367'
  file_name: 2020_Tkadlec_Thesis.pdf
  file_size: 11670983
  relation: main_file
file_date_updated: 2020-07-14T12:47:52Z
fulldoi: https://doi.org/10.15479/AT:ISTA:7196
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '144'
publication_identifier:
  eissn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '5751'
    relation: dissertation_contains
    status: public
  - id: '7210'
    relation: dissertation_contains
    status: public
  - id: '7212'
    relation: dissertation_contains
    status: public
status: public
supervisor:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
title: A role of graphs in evolutionary processes
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
OA_place: publisher
_id: '7460'
abstract:
- lang: eng
  text: "Many methods for the reconstruction of shapes from sets of points produce
    ordered simplicial complexes, which are collections of vertices, edges, triangles,
    and their higher-dimensional analogues, called simplices, in which every simplex
    gets assigned a real value measuring its size. This thesis studies ordered simplicial
    complexes, with a focus on their topology, which reflects the connectedness of
    the represented shapes and the presence of holes. We are interested both in understanding
    better the structure of these complexes, as well as in developing algorithms for
    applications.\r\n\r\nFor the Delaunay triangulation, the most popular measure
    for a simplex is the radius of the smallest empty circumsphere. Based on it, we
    revisit Alpha and Wrap complexes and experimentally determine their probabilistic
    properties for random data. Also, we prove the existence of tri-partitions, propose
    algorithms to open and close holes, and extend the concepts from Euclidean to
    Bregman geometries."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Katharina
  full_name: Ölsböck, Katharina
  id: 4D4AA390-F248-11E8-B48F-1D18A9856A87
  last_name: Ölsböck
  orcid: 0000-0002-4672-8297
citation:
  ama: Ölsböck K. The hole system of triangulated shapes. 2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:7460">10.15479/AT:ISTA:7460</a>
  apa: Ölsböck, K. (2020). <i>The hole system of triangulated shapes</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:7460">https://doi.org/10.15479/AT:ISTA:7460</a>
  chicago: Ölsböck, Katharina. “The Hole System of Triangulated Shapes.” Institute
    of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:7460">https://doi.org/10.15479/AT:ISTA:7460</a>.
  ieee: K. Ölsböck, “The hole system of triangulated shapes,” Institute of Science
    and Technology Austria, 2020.
  ista: Ölsböck K. 2020. The hole system of triangulated shapes. Institute of Science
    and Technology Austria.
  mla: Ölsböck, Katharina. <i>The Hole System of Triangulated Shapes</i>. Institute
    of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:7460">10.15479/AT:ISTA:7460</a>.
  short: K. Ölsböck, The Hole System of Triangulated Shapes, Institute of Science
    and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-02-06T14:56:53Z
date_published: 2020-02-10T00:00:00Z
date_updated: 2026-04-08T07:23:21Z
day: '10'
ddc:
- '514'
degree_awarded: PhD
department:
- _id: HeEd
- _id: GradSch
doi: 10.15479/AT:ISTA:7460
file:
- access_level: open_access
  checksum: 1df9f8c530b443c0e63a3f2e4fde412e
  content_type: application/pdf
  creator: koelsboe
  date_created: 2020-02-06T14:43:54Z
  date_updated: 2020-07-14T12:47:58Z
  file_id: '7461'
  file_name: thesis_ist-final_noack.pdf
  file_size: 76195184
  relation: main_file
- access_level: closed
  checksum: 7a52383c812b0be64d3826546509e5a4
  content_type: application/x-zip-compressed
  creator: koelsboe
  date_created: 2020-02-06T14:52:45Z
  date_updated: 2020-07-14T12:47:58Z
  description: latex source files, figures
  file_id: '7462'
  file_name: latex-files.zip
  file_size: 122103715
  relation: source_file
file_date_updated: 2020-07-14T12:47:58Z
fulldoi: https://doi.org/10.15479/AT:ISTA:7460
has_accepted_license: '1'
keyword:
- shape reconstruction
- hole manipulation
- ordered complexes
- Alpha complex
- Wrap complex
- computational topology
- Bregman geometry
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: '155'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6608'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
title: The hole system of triangulated shapes
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
OA_place: publisher
_id: '7514'
abstract:
- lang: eng
  text: "We study the interacting homogeneous Bose gas in two spatial dimensions in
    the thermodynamic limit at fixed density. We shall be concerned with some mathematical
    aspects of this complicated problem in many-body quantum mechanics. More specifically,
    we consider the dilute limit where the scattering length of the interaction potential,
    which is a measure for the effective range of the potential, is small compared
    to the average distance between the particles. We are interested in a setting
    with positive (i.e., non-zero) temperature. After giving a survey of the relevant
    literature in the field, we provide some facts and examples to set expectations
    for the two-dimensional system. The crucial difference to the three-dimensional
    system is that there is no Bose–Einstein condensate at positive temperature due
    to the Hohenberg–Mermin–Wagner theorem. However, it turns out that an asymptotic
    formula for the free energy holds similarly to the three-dimensional case.\r\nWe
    motivate this formula by considering a toy model with δ interaction potential.
    By restricting this model Hamiltonian to certain trial states with a quasi-condensate
    we obtain an upper bound for the free energy that still has the quasi-condensate
    fraction as a free parameter. When minimizing over the quasi-condensate fraction,
    we obtain the Berezinskii–Kosterlitz–Thouless critical temperature for superfluidity,
    which plays an important role in our rigorous contribution. The mathematically
    rigorous result that we prove concerns the specific free energy in the dilute
    limit. We give upper and lower bounds on the free energy in terms of the free
    energy of the non-interacting system and a correction term coming from the interaction.
    Both bounds match and thus we obtain the leading term of an asymptotic approximation
    in the dilute limit, provided the thermal wavelength of the particles is of the
    same order (or larger) than the average distance between the particles. The remarkable
    feature of this result is its generality: the correction term depends on the interaction
    potential only through its scattering length and it holds for all nonnegative
    interaction potentials with finite scattering length that are measurable. In particular,
    this allows to model an interaction of hard disks."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Simon
  full_name: Mayer, Simon
  id: 30C4630A-F248-11E8-B48F-1D18A9856A87
  last_name: Mayer
citation:
  ama: Mayer S. The free energy of a dilute two-dimensional Bose gas. 2020. doi:<a
    href="https://doi.org/10.15479/AT:ISTA:7514">10.15479/AT:ISTA:7514</a>
  apa: Mayer, S. (2020). <i>The free energy of a dilute two-dimensional Bose gas</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:7514">https://doi.org/10.15479/AT:ISTA:7514</a>
  chicago: Mayer, Simon. “The Free Energy of a Dilute Two-Dimensional Bose Gas.” Institute
    of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:7514">https://doi.org/10.15479/AT:ISTA:7514</a>.
  ieee: S. Mayer, “The free energy of a dilute two-dimensional Bose gas,” Institute
    of Science and Technology Austria, 2020.
  ista: Mayer S. 2020. The free energy of a dilute two-dimensional Bose gas. Institute
    of Science and Technology Austria.
  mla: Mayer, Simon. <i>The Free Energy of a Dilute Two-Dimensional Bose Gas</i>.
    Institute of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:7514">10.15479/AT:ISTA:7514</a>.
  short: S. Mayer, The Free Energy of a Dilute Two-Dimensional Bose Gas, Institute
    of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-02-24T09:17:27Z
date_published: 2020-02-24T00:00:00Z
date_updated: 2026-04-08T07:25:40Z
day: '24'
ddc:
- '510'
degree_awarded: PhD
department:
- _id: RoSe
- _id: GradSch
doi: 10.15479/AT:ISTA:7514
ec_funded: 1
file:
- access_level: open_access
  checksum: b4de7579ddc1dbdd44ff3f17c48395f6
  content_type: application/pdf
  creator: dernst
  date_created: 2020-02-24T09:15:06Z
  date_updated: 2020-07-14T12:47:59Z
  file_id: '7515'
  file_name: thesis.pdf
  file_size: 1563429
  relation: main_file
- access_level: closed
  checksum: ad7425867b52d7d9e72296e87bc9cb67
  content_type: application/x-zip-compressed
  creator: dernst
  date_created: 2020-02-24T09:15:16Z
  date_updated: 2020-07-14T12:47:59Z
  file_id: '7516'
  file_name: thesis_source.zip
  file_size: 2028038
  relation: source_file
file_date_updated: 2020-07-14T12:47:59Z
fulldoi: https://doi.org/10.15479/AT:ISTA:7514
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '148'
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '7524'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
title: The free energy of a dilute two-dimensional Bose gas
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '8382'
abstract:
- lang: eng
  text: We present the first deterministic wait-free long-lived snapshot algorithm,
    using only read and write operations, that guarantees polylogarithmic amortized
    step complexity in all executions. This is the first non-blocking snapshot algorithm,
    using reads and writes only, that has sub-linear amortized step complexity in
    executions of arbitrary length. The key to our construction is a novel implementation
    of a 2-component max array object which may be of independent interest.
article_processing_charge: No
author:
- first_name: Mirza Ahad
  full_name: Baig, Mirza Ahad
  id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425
  last_name: Baig
- first_name: Danny
  full_name: Hendler, Danny
  last_name: Hendler
- first_name: Alessia
  full_name: Milani, Alessia
  last_name: Milani
- first_name: Corentin
  full_name: Travers, Corentin
  last_name: Travers
citation:
  ama: 'Baig MA, Hendler D, Milani A, Travers C. Long-lived snapshots with polylogarithmic
    amortized step complexity. In: <i>Proceedings of the 39th Symposium on Principles
    of Distributed Computing</i>. Association for Computing Machinery; 2020:31-40.
    doi:<a href="https://doi.org/10.1145/3382734.3406005">10.1145/3382734.3406005</a>'
  apa: 'Baig, M. A., Hendler, D., Milani, A., &#38; Travers, C. (2020). Long-lived
    snapshots with polylogarithmic amortized step complexity. In <i>Proceedings of
    the 39th Symposium on Principles of Distributed Computing</i> (pp. 31–40). Virtual,
    Italy: Association for Computing Machinery. <a href="https://doi.org/10.1145/3382734.3406005">https://doi.org/10.1145/3382734.3406005</a>'
  chicago: Baig, Mirza Ahad, Danny Hendler, Alessia Milani, and Corentin Travers.
    “Long-Lived Snapshots with Polylogarithmic Amortized Step Complexity.” In <i>Proceedings
    of the 39th Symposium on Principles of Distributed Computing</i>, 31–40. Association
    for Computing Machinery, 2020. <a href="https://doi.org/10.1145/3382734.3406005">https://doi.org/10.1145/3382734.3406005</a>.
  ieee: M. A. Baig, D. Hendler, A. Milani, and C. Travers, “Long-lived snapshots with
    polylogarithmic amortized step complexity,” in <i>Proceedings of the 39th Symposium
    on Principles of Distributed Computing</i>, Virtual, Italy, 2020, pp. 31–40.
  ista: 'Baig MA, Hendler D, Milani A, Travers C. 2020. Long-lived snapshots with
    polylogarithmic amortized step complexity. Proceedings of the 39th Symposium on
    Principles of Distributed Computing. PODC: Principles of Distributed Computing,
    31–40.'
  mla: Baig, Mirza Ahad, et al. “Long-Lived Snapshots with Polylogarithmic Amortized
    Step Complexity.” <i>Proceedings of the 39th Symposium on Principles of Distributed
    Computing</i>, Association for Computing Machinery, 2020, pp. 31–40, doi:<a href="https://doi.org/10.1145/3382734.3406005">10.1145/3382734.3406005</a>.
  short: M.A. Baig, D. Hendler, A. Milani, C. Travers, in:, Proceedings of the 39th
    Symposium on Principles of Distributed Computing, Association for Computing Machinery,
    2020, pp. 31–40.
conference:
  end_date: 2020-08-07
  location: Virtual, Italy
  name: 'PODC: Principles of Distributed Computing'
  start_date: 2020-08-03
das_tickbox: '1'
date_created: 2020-09-13T22:01:17Z
date_published: 2020-07-31T00:00:00Z
date_updated: 2026-07-28T09:50:30Z
day: '31'
department:
- _id: GradSch
doi: 10.1145/3382734.3406005
external_id:
  isi:
  - '001436693500004'
fulldoi: https://doi.org/10.1145/3382734.3406005
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://hal.archives-ouvertes.fr/hal-02860087/document
month: '07'
oa: 1
oa_version: Preprint
page: 31-40
publication: Proceedings of the 39th Symposium on Principles of Distributed Computing
publication_identifier:
  isbn:
  - '9781450375825'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Long-lived snapshots with polylogarithmic amortized step complexity
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: publisher
_id: '7896'
abstract:
- lang: eng
  text: "A search problem lies in the complexity class FNP if a solution to the given
    instance of the problem can be verified efficiently. The complexity class TFNP
    consists of all search problems in FNP that are total in the sense that a solution
    is guaranteed to exist. TFNP contains a host of interesting problems from fields
    such as algorithmic game theory, computational topology, number theory and combinatorics.
    Since TFNP is a semantic class, it is unlikely to have a complete problem. Instead,
    one studies its syntactic subclasses which are defined based on the combinatorial
    principle used to argue totality. Of particular interest is the subclass PPAD,
    which contains important problems\r\nlike computing Nash equilibrium for bimatrix
    games and computational counterparts of several fixed-point theorems as complete.
    In the thesis, we undertake the study of averagecase hardness of TFNP, and in
    particular its subclass PPAD.\r\nAlmost nothing was known about average-case hardness
    of PPAD before a series of recent results showed how to achieve it using a cryptographic
    primitive called program obfuscation.\r\nHowever, it is currently not known how
    to construct program obfuscation from standard cryptographic assumptions. Therefore,
    it is desirable to relax the assumption under which average-case hardness of PPAD
    can be shown. In the thesis we take a step in this direction. First, we show that
    assuming the (average-case) hardness of a numbertheoretic\r\nproblem related to
    factoring of integers, which we call Iterated-Squaring, PPAD is hard-on-average
    in the random-oracle model. Then we strengthen this result to show that the average-case
    hardness of PPAD reduces to the (adaptive) soundness of the Fiat-Shamir Transform,
    a well-known technique used to compile a public-coin interactive protocol into
    a non-interactive one. As a corollary, we obtain average-case hardness for PPAD
    in the random-oracle model assuming the worst-case hardness of #SAT. Moreover,
    the above results can all be strengthened to obtain average-case hardness for
    the class CLS ⊆ PPAD.\r\nOur main technical contribution is constructing incrementally-verifiable
    procedures for computing Iterated-Squaring and #SAT. By incrementally-verifiable,
    we mean that every intermediate state of the computation includes a proof of its
    correctness, and the proof can be updated and verified in polynomial time. Previous
    constructions of such procedures relied on strong, non-standard assumptions. Instead,
    we introduce a technique called recursive proof-merging to obtain the same from
    weaker assumptions. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Chethan
  full_name: Kamath Hosdurg, Chethan
  id: 4BD3F30E-F248-11E8-B48F-1D18A9856A87
  last_name: Kamath Hosdurg
  orcid: 0009-0006-6812-7317
citation:
  ama: Kamath Hosdurg C. On the average-case hardness of total search problems. 2020.
    doi:<a href="https://doi.org/10.15479/AT:ISTA:7896">10.15479/AT:ISTA:7896</a>
  apa: Kamath Hosdurg, C. (2020). <i>On the average-case hardness of total search
    problems</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:7896">https://doi.org/10.15479/AT:ISTA:7896</a>
  chicago: Kamath Hosdurg, Chethan. “On the Average-Case Hardness of Total Search
    Problems.” Institute of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:7896">https://doi.org/10.15479/AT:ISTA:7896</a>.
  ieee: C. Kamath Hosdurg, “On the average-case hardness of total search problems,”
    Institute of Science and Technology Austria, 2020.
  ista: Kamath Hosdurg C. 2020. On the average-case hardness of total search problems.
    Institute of Science and Technology Austria.
  mla: Kamath Hosdurg, Chethan. <i>On the Average-Case Hardness of Total Search Problems</i>.
    Institute of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:7896">10.15479/AT:ISTA:7896</a>.
  short: C. Kamath Hosdurg, On the Average-Case Hardness of Total Search Problems,
    Institute of Science and Technology Austria, 2020.
corr_author: '1'
date_created: 2020-05-26T14:08:55Z
date_published: 2020-05-25T00:00:00Z
date_updated: 2026-07-30T13:43:53Z
day: '25'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: KrPi
- _id: GradSch
doi: 10.15479/AT:ISTA:7896
doi_confirm: '1'
ec_funded: 1
file:
- access_level: open_access
  checksum: b39e2e1c376f5819b823fb7077491c64
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-26T14:08:13Z
  date_updated: 2020-07-14T12:48:04Z
  file_id: '7897'
  file_name: 2020_Thesis_Kamath.pdf
  file_size: 1622742
  relation: main_file
- access_level: closed
  checksum: 8b26ba729c1a85ac6bea775f5d73cdc7
  content_type: application/x-zip-compressed
  creator: dernst
  date_created: 2020-05-26T14:08:23Z
  date_updated: 2020-07-14T12:48:04Z
  file_id: '7898'
  file_name: Thesis_Kamath.zip
  file_size: 15301529
  relation: source_file
file_date_updated: 2020-07-14T12:48:04Z
fulldoi: https://doi.org/10.15479/AT:ISTA:7896
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '126'
project:
- _id: 258C570E-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '259668'
  name: Provable Security for Physical Cryptography
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6677'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
title: On the average-case hardness of total search problems
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '10190'
abstract:
- lang: eng
  text: 'The verification of concurrent programs remains an open challenge, as thread
    interaction has to be accounted for, which leads to state-space explosion. Stateless
    model checking battles this problem by exploring traces rather than states of
    the program. As there are exponentially many traces, dynamic partial-order reduction
    (DPOR) techniques are used to partition the trace space into equivalence classes,
    and explore a few representatives from each class. The standard equivalence that
    underlies most DPOR techniques is the happens-before equivalence, however recent
    works have spawned a vivid interest towards coarser equivalences. The efficiency
    of such approaches is a product of two parameters: (i) the size of the partitioning
    induced by the equivalence, and (ii) the time spent by the exploration algorithm
    in each class of the partitioning. In this work, we present a new equivalence,
    called value-happens-before and show that it has two appealing features. First,
    value-happens-before is always at least as coarse as the happens-before equivalence,
    and can be even exponentially coarser. Second, the value-happens-before partitioning
    is efficiently explorable when the number of threads is bounded. We present an
    algorithm called value-centric DPOR (VCDPOR), which explores the underlying partitioning
    using polynomial time per class. Finally, we perform an experimental evaluation
    of VCDPOR on various benchmarks, and compare it against other state-of-the-art
    approaches. Our results show that value-happens-before typically induces a significant
    reduction in the size of the underlying partitioning, which leads to a considerable
    reduction in the running time for exploring the whole partitioning.'
acknowledgement: "The authors would also like to thank anonymous referees for their
  valuable comments and helpful suggestions. This work is supported by the Austrian
  Science Fund (FWF) NFN grants S11407-N23 (RiSE/SHiNE) and S11402-N23 (RiSE/SHiNE),
  by the Vienna Science and Technology Fund (WWTF) Project ICT15-003, and by the Austrian
  Science Fund (FWF) Schrodinger grant J-4220.\r\n"
article_number: '124'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Andreas
  full_name: Pavlogiannis, Andreas
  id: 49704004-F248-11E8-B48F-1D18A9856A87
  last_name: Pavlogiannis
  orcid: 0000-0002-8943-0722
- first_name: Viktor
  full_name: Toman, Viktor
  id: 3AF3DA7C-F248-11E8-B48F-1D18A9856A87
  last_name: Toman
  orcid: 0000-0001-9036-063X
citation:
  ama: 'Chatterjee K, Pavlogiannis A, Toman V. Value-centric dynamic partial order
    reduction. In: <i>Proceedings of the 34th ACM International Conference on Object-Oriented
    Programming, Systems, Languages, and Applications</i>. Vol 3. ACM; 2019. doi:<a
    href="https://doi.org/10.1145/3360550">10.1145/3360550</a>'
  apa: 'Chatterjee, K., Pavlogiannis, A., &#38; Toman, V. (2019). Value-centric dynamic
    partial order reduction. In <i>Proceedings of the 34th ACM International Conference
    on Object-Oriented Programming, Systems, Languages, and Applications</i> (Vol.
    3). Athens, Greece: ACM. <a href="https://doi.org/10.1145/3360550">https://doi.org/10.1145/3360550</a>'
  chicago: Chatterjee, Krishnendu, Andreas Pavlogiannis, and Viktor Toman. “Value-Centric
    Dynamic Partial Order Reduction.” In <i>Proceedings of the 34th ACM International
    Conference on Object-Oriented Programming, Systems, Languages, and Applications</i>,
    Vol. 3. ACM, 2019. <a href="https://doi.org/10.1145/3360550">https://doi.org/10.1145/3360550</a>.
  ieee: K. Chatterjee, A. Pavlogiannis, and V. Toman, “Value-centric dynamic partial
    order reduction,” in <i>Proceedings of the 34th ACM International Conference on
    Object-Oriented Programming, Systems, Languages, and Applications</i>, Athens,
    Greece, 2019, vol. 3.
  ista: 'Chatterjee K, Pavlogiannis A, Toman V. 2019. Value-centric dynamic partial
    order reduction. Proceedings of the 34th ACM International Conference on Object-Oriented
    Programming, Systems, Languages, and Applications. OOPSLA: Object-oriented Programming,
    Systems, Languages and Applications vol. 3, 124.'
  mla: Chatterjee, Krishnendu, et al. “Value-Centric Dynamic Partial Order Reduction.”
    <i>Proceedings of the 34th ACM International Conference on Object-Oriented Programming,
    Systems, Languages, and Applications</i>, vol. 3, 124, ACM, 2019, doi:<a href="https://doi.org/10.1145/3360550">10.1145/3360550</a>.
  short: K. Chatterjee, A. Pavlogiannis, V. Toman, in:, Proceedings of the 34th ACM
    International Conference on Object-Oriented Programming, Systems, Languages, and
    Applications, ACM, 2019.
conference:
  end_date: 2019-10-25
  location: Athens, Greece
  name: 'OOPSLA: Object-oriented Programming, Systems, Languages and Applications'
  start_date: 2019-10-23
corr_author: '1'
date_created: 2021-10-27T14:57:06Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2026-04-08T07:00:31Z
day: '10'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3360550
external_id:
  arxiv:
  - '1909.00989'
file:
- access_level: open_access
  checksum: 2149979c46964c4d117af06ccb6c0834
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-12T11:41:56Z
  date_updated: 2021-11-12T11:41:56Z
  file_id: '10278'
  file_name: 2019_ACM_Chatterjee.pdf
  file_size: 570829
  relation: main_file
  success: 1
file_date_updated: 2021-11-12T11:41:56Z
fulldoi: https://doi.org/10.1145/3360550
has_accepted_license: '1'
intvolume: '         3'
keyword:
- safety
- risk
- reliability and quality
- software
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11402-N23
  name: Moderne Concurrency Paradigms
publication: Proceedings of the 34th ACM International Conference on Object-Oriented
  Programming, Systems, Languages, and Applications
publication_identifier:
  eissn:
  - 2475-1421
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
  record:
  - id: '10199'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Value-centric dynamic partial order reduction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2019'
...
---
OA_place: publisher
_id: '6179'
abstract:
- lang: eng
  text: "In the first part of this thesis we consider large random matrices with arbitrary
    expectation and a general slowly decaying correlation among its entries. We prove
    universality of the local eigenvalue statistics and optimal local laws for the
    resolvent in the bulk and edge regime. The main novel tool is a systematic diagrammatic
    control of a multivariate cumulant expansion.\r\nIn the second part we consider
    Wigner-type matrices and show that at any cusp singularity of the limiting eigenvalue
    distribution the local eigenvalue statistics are uni- versal and form a Pearcey
    process. Since the density of states typically exhibits only square root or cubic
    root cusp singularities, our work complements previous results on the bulk and
    edge universality and it thus completes the resolution of the Wigner- Dyson-Mehta
    universality conjecture for the last remaining universality type. Our analysis
    holds not only for exact cusps, but approximate cusps as well, where an ex- tended
    Pearcey process emerges. As a main technical ingredient we prove an optimal local
    law at the cusp, and extend the fast relaxation to equilibrium of the Dyson Brow-
    nian motion to the cusp regime.\r\nIn the third and final part we explore the
    entrywise linear statistics of Wigner ma- trices and identify the fluctuations
    for a large class of test functions with little regularity. This enables us to
    study the rectangular Young diagram obtained from the interlacing eigenvalues
    of the random matrix and its minor, and we find that, despite having the same
    limit, the fluctuations differ from those of the algebraic Young tableaux equipped
    with the Plancharel measure."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: 'Schröder DJ. From Dyson to Pearcey: Universal statistics in random matrix
    theory. 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:th6179">10.15479/AT:ISTA:th6179</a>'
  apa: 'Schröder, D. J. (2019). <i>From Dyson to Pearcey: Universal statistics in
    random matrix theory</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th6179">https://doi.org/10.15479/AT:ISTA:th6179</a>'
  chicago: 'Schröder, Dominik J. “From Dyson to Pearcey: Universal Statistics in Random
    Matrix Theory.” Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:th6179">https://doi.org/10.15479/AT:ISTA:th6179</a>.'
  ieee: 'D. J. Schröder, “From Dyson to Pearcey: Universal statistics in random matrix
    theory,” Institute of Science and Technology Austria, 2019.'
  ista: 'Schröder DJ. 2019. From Dyson to Pearcey: Universal statistics in random
    matrix theory. Institute of Science and Technology Austria.'
  mla: 'Schröder, Dominik J. <i>From Dyson to Pearcey: Universal Statistics in Random
    Matrix Theory</i>. Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:th6179">10.15479/AT:ISTA:th6179</a>.'
  short: 'D.J. Schröder, From Dyson to Pearcey: Universal Statistics in Random Matrix
    Theory, Institute of Science and Technology Austria, 2019.'
corr_author: '1'
date_created: 2019-03-28T08:58:59Z
date_published: 2019-03-18T00:00:00Z
date_updated: 2026-07-29T13:46:20Z
day: '18'
ddc:
- '515'
- '519'
degree_awarded: PhD
department:
- _id: LaEr
- _id: GradSch
doi: 10.15479/AT:ISTA:th6179
doi_confirm: '1'
ec_funded: 1
file:
- access_level: closed
  checksum: 6926f66f28079a81c4937e3764be00fc
  content_type: application/x-gzip
  creator: dernst
  date_created: 2019-03-28T08:53:52Z
  date_updated: 2020-07-14T12:47:21Z
  file_id: '6180'
  file_name: 2019_Schroeder_Thesis.tar.gz
  file_size: 7104482
  relation: source_file
- access_level: open_access
  checksum: 7d0ebb8d1207e89768cdd497a5bf80fb
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-28T08:53:52Z
  date_updated: 2020-07-14T12:47:21Z
  file_id: '6181'
  file_name: 2019_Schroeder_Thesis.pdf
  file_size: 4228794
  relation: main_file
file_date_updated: 2020-07-14T12:47:21Z
fulldoi: https://doi.org/10.15479/AT:ISTA:th6179
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '375'
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6184'
    relation: part_of_dissertation
    status: public
  - id: '6186'
    relation: part_of_dissertation
    status: public
  - id: '6185'
    relation: part_of_dissertation
    status: public
  - id: '1012'
    relation: part_of_dissertation
    status: public
  - id: '1144'
    relation: part_of_dissertation
    status: public
  - id: '6182'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
title: 'From Dyson to Pearcey: Universal statistics in random matrix theory'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
OA_place: publisher
_id: '6825'
abstract:
- lang: eng
  text: "The solving of complex tasks requires the functions of more than one brain
    area and their interaction. Whilst spatial navigation and memory is dependent
    on the hippocampus, flexible behavior relies on the medial prefrontal cortex (mPFC).
    To further examine the roles of the hippocampus and mPFC, we recorded their neural
    activity during a task that depends on both of these brain regions.\r\nWith tetrodes,
    we recorded the extracellular activity of dorsal hippocampal CA1 (HPC) and mPFC
    neurons in Long-Evans rats performing a rule-switching task on the plus-maze.
    The plus-maze task had a spatial component since it required navigation along
    one of the two start arms and at the maze center a choice between one of the two
    goal arms. Which goal contained a reward depended on the rule currently in place.
    After an uncued rule change the animal had to abandon the old strategy and switch
    to the new rule, testing cognitive flexibility. Investigating the coordination
    of activity between the HPC and mPFC allows determination during which task stages
    their interaction is required. Additionally, comparing neural activity patterns
    in these two brain regions allows delineation of the specialized functions of
    the HPC and mPFC in this task. We analyzed neural activity in the HPC and mPFC
    in terms of oscillatory interactions, rule coding and replay.\r\nWe found that
    theta coherence between the HPC and mPFC is increased at the center and goals
    of the maze, both when the rule was stable or has changed. Similar results were
    found for locking of HPC and mPFC neurons to HPC theta oscillations. However,
    no differences in HPC-mPFC theta coordination were observed between the spatially-
    and cue-guided rule. Phase locking of HPC and mPFC neurons to HPC gamma oscillations
    was not modulated by\r\nmaze position or rule type. We found that the HPC coded
    for the two different rules with cofiring relationships between\r\ncell pairs.
    However, we could not find conclusive evidence for rule coding in the mPFC. Spatially-selective
    firing in the mPFC generalized between the two start and two goal arms. With Bayesian
    positional decoding, we found that the mPFC reactivated non-local positions during
    awake immobility periods. Replay of these non-local positions could represent
    entire behavioral trajectories resembling trajectory replay of the HPC. Furthermore,
    mPFC\r\ntrajectory-replay at the goal positively correlated with rule-switching
    performance. \r\nFinally, HPC and mPFC trajectory replay occurred independently
    of each other. These results show that the mPFC can replay ordered patterns of
    activity during awake immobility, possibly underlying its role in flexible behavior. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Karola
  full_name: Käfer, Karola
  id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
  last_name: Käfer
citation:
  ama: Käfer K. The hippocampus and medial prefrontal cortex during flexible behavior.
    2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6825">10.15479/AT:ISTA:6825</a>
  apa: Käfer, K. (2019). <i>The hippocampus and medial prefrontal cortex during flexible
    behavior</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:6825">https://doi.org/10.15479/AT:ISTA:6825</a>
  chicago: Käfer, Karola. “The Hippocampus and Medial Prefrontal Cortex during Flexible
    Behavior.” Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:6825">https://doi.org/10.15479/AT:ISTA:6825</a>.
  ieee: K. Käfer, “The hippocampus and medial prefrontal cortex during flexible behavior,”
    Institute of Science and Technology Austria, 2019.
  ista: Käfer K. 2019. The hippocampus and medial prefrontal cortex during flexible
    behavior. Institute of Science and Technology Austria.
  mla: Käfer, Karola. <i>The Hippocampus and Medial Prefrontal Cortex during Flexible
    Behavior</i>. Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6825">10.15479/AT:ISTA:6825</a>.
  short: K. Käfer, The Hippocampus and Medial Prefrontal Cortex during Flexible Behavior,
    Institute of Science and Technology Austria, 2019.
corr_author: '1'
date_created: 2019-08-21T15:00:57Z
date_published: 2019-08-24T00:00:00Z
date_updated: 2026-04-08T13:56:14Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: JoCs
- _id: GradSch
doi: 10.15479/AT:ISTA:6825
file:
- access_level: open_access
  checksum: 2664420e332a33338568f4f3bfc59287
  content_type: application/pdf
  creator: kkaefer
  date_created: 2019-09-03T08:07:13Z
  date_updated: 2020-09-06T22:30:03Z
  embargo: 2020-09-05
  file_id: '6846'
  file_name: Thesis_Kaefer_PDFA.pdf
  file_size: 3205202
  relation: main_file
  request_a_copy: 0
- access_level: closed
  checksum: 9a154eab6f07aa590a3d2651dc0d926a
  content_type: application/zip
  creator: kkaefer
  date_created: 2019-09-03T08:07:17Z
  date_updated: 2024-04-10T22:30:48Z
  embargo_to: open_access
  file_id: '6847'
  file_name: Thesis_Kaefer.zip
  file_size: 2506835
  relation: source_file
file_date_updated: 2024-04-10T22:30:48Z
fulldoi: https://doi.org/10.15479/AT:ISTA:6825
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '89'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '5949'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
title: The hippocampus and medial prefrontal cortex during flexible behavior
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2019'
...
---
OA_place: publisher
_id: '6546'
abstract:
- lang: eng
  text: "Invasive migration plays a crucial role not only during development and homeostasis
    but also in pathological states, such as tumor metastasis. Drosophila macrophage
    migration into the extended germband is an interesting system to study invasive
    migration. It carries similarities to immune cell transmigration and cancer cell
    invasion, therefore studying this process could also bring new understanding of
    invasion in higher organisms. In our work, we uncover a highly conserved member
    of the major facilitator family that plays a role in tissue invasion through regulation
    of glycosylation on a subgroup of proteins and/or by aiding the precise timing
    of DN-Cadherin downregulation. \r\n\r\nAberrant display of the truncated core1
    O-glycan T-antigen is a common feature of human cancer cells that correlates with
    metastasis. Here we show that T-antigen in Drosophila melanogaster macrophages
    is involved in their developmentally programmed tissue invasion. Higher macrophage
    T-antigen levels require an atypical major facilitator superfamily (MFS) member
    that we named Minerva which enables macrophage dissemination and invasion. We
    characterize for the first time the T and Tn glycoform O-glycoproteome of the
    Drosophila melanogaster embryo, and determine that Minerva increases the presence
    of T-antigen on proteins in pathways previously linked to cancer, most strongly
    on the sulfhydryl oxidase Qsox1 which we show is required for macrophage tissue
    entry. Minerva’s vertebrate ortholog, MFSD1, rescues the minerva mutant’s migration
    and T-antigen glycosylation defects. We thus identify \r\na key conserved regulator
    that orchestrates O-glycosylation on a protein subset to activate \r\na program
    governing migration steps important for both development and cancer metastasis.
    \r\n"
acknowledged_ssus:
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Katarina
  full_name: Valosková, Katarina
  id: 46F146FC-F248-11E8-B48F-1D18A9856A87
  last_name: Valosková
  orcid: 0000-0002-7926-0221
citation:
  ama: Valosková K. The role of a highly conserved major facilitator superfamily member
    in Drosophila embryonic macrophage migration. 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6546">10.15479/AT:ISTA:6546</a>
  apa: Valosková, K. (2019). <i>The role of a highly conserved major facilitator superfamily
    member in Drosophila embryonic macrophage migration</i>. Institute of Science
    and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:6546">https://doi.org/10.15479/AT:ISTA:6546</a>
  chicago: Valosková, Katarina. “The Role of a Highly Conserved Major Facilitator
    Superfamily Member in Drosophila Embryonic Macrophage Migration.” Institute of
    Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:6546">https://doi.org/10.15479/AT:ISTA:6546</a>.
  ieee: K. Valosková, “The role of a highly conserved major facilitator superfamily
    member in Drosophila embryonic macrophage migration,” Institute of Science and
    Technology Austria, 2019.
  ista: Valosková K. 2019. The role of a highly conserved major facilitator superfamily
    member in Drosophila embryonic macrophage migration. Institute of Science and
    Technology Austria.
  mla: Valosková, Katarina. <i>The Role of a Highly Conserved Major Facilitator Superfamily
    Member in Drosophila Embryonic Macrophage Migration</i>. Institute of Science
    and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6546">10.15479/AT:ISTA:6546</a>.
  short: K. Valosková, The Role of a Highly Conserved Major Facilitator Superfamily
    Member in Drosophila Embryonic Macrophage Migration, Institute of Science and
    Technology Austria, 2019.
corr_author: '1'
date_created: 2019-06-07T12:49:19Z
date_published: 2019-06-07T00:00:00Z
date_updated: 2026-09-03T06:37:27Z
day: '07'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: DaSi
- _id: GradSch
doi: 10.15479/AT:ISTA:6546
doi_confirm: '1'
file:
- access_level: closed
  checksum: 68949c2d96210b45b981a23e9c9cd93c
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: khribikova
  date_created: 2019-06-07T13:00:04Z
  date_updated: 2020-07-14T12:47:33Z
  embargo_to: open_access
  file_id: '6549'
  file_name: Katarina Valoskova_PhD thesis_final version.docx
  file_size: 14110626
  relation: source_file
- access_level: open_access
  checksum: 555329cd76e196c96f5278c480ee2e6e
  content_type: application/pdf
  creator: khribikova
  date_created: 2019-06-07T13:00:08Z
  date_updated: 2021-02-11T11:17:14Z
  embargo: 2020-06-07
  file_id: '6550'
  file_name: Katarina Valoskova_PhD thesis_final version.pdf
  file_size: 10054156
  relation: main_file
file_date_updated: 2021-02-11T11:17:14Z
fulldoi: https://doi.org/10.15479/AT:ISTA:6546
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '141'
project:
- _id: 253CDE40-B435-11E9-9278-68D0E5697425
  grant_number: '24283'
  name: Examination of the role of a MFS transporter in the migration of Drosophila
    immune cells
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '544'
    relation: part_of_dissertation
    status: public
  - id: '6187'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Daria E
  full_name: Siekhaus, Daria E
  id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
  last_name: Siekhaus
  orcid: 0000-0001-8323-8353
title: The role of a highly conserved major facilitator superfamily member in Drosophila
  embryonic macrophage migration
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
OA_place: publisher
_id: '6849'
abstract:
- lang: eng
  text: 'Brain function is mediated by complex dynamical interactions between excitatory
    and inhibitory cell types. The Cholecystokinin-expressing inhibitory cells (CCK-interneurons)
    are one of the least studied types, despite being suspected to play important
    roles in cognitive processes. We studied the network effects of optogenetic silencing
    of CCK-interneurons in the CA1 hippocampal area during exploration and sleep states.
    The cell firing pattern in response to light pulses allowed us to classify the
    recorded neurons in 5 classes, including disinhibited and non-responsive pyramidal
    cell and interneurons, and the inhibited interneurons corresponding to the CCK
    group. The light application, which inhibited the activity of CCK interneurons
    triggered wider changes in the firing dynamics of cells. We observed rate changes
    (i.e. remapping) of pyramidal cells during the exploration session in which the
    light was applied relative to the previous control session that was not restricted
    neither in time nor space to the light delivery. Also, the disinhibited pyramidal
    cells had higher increase in bursting than in single spike firing rate as a result
    of CCK silencing. In addition, the firing activity patterns during exploratory
    periods were more weakly reactivated in sleep for those periods in which CCK-interneuron
    were silenced than in the unaffected periods. Furthermore, light pulses during
    sleep disrupted the reactivation of recent waking patterns. Hence, silencing CCK
    neurons during exploration suppressed the reactivation of waking firing patterns
    in sleep and CCK interneuron activity was also required during sleep for the normal
    reactivation of waking patterns. These findings demonstrate the involvement of
    CCK cells in reactivation-related memory consolidation. An important part of our
    analysis was to test the relationship of the identified CCKinterneurons to brain
    oscillations. Our findings showed that these cells exhibited different oscillatory
    behaviour during anaesthesia and natural waking and sleep conditions. We showed
    that: 1) Contrary to the past studies performed under anaesthesia, the identified
    CCKinterneurons fired on the descending portion of the theta phase in waking exploration.
    2) CCKinterneuron preferred phases around the trough of gamma oscillations. 3)
    Contrary to anaesthesia conditions, the average firing rate of the CCK-interneurons
    increased around the peak activity of the sharp-wave ripple (SWR) events in natural
    sleep, which is congruent with new reports about their functional connectivity.
    We also found that light driven CCK-interneuron silencing altered the dynamics
    on the CA1 network oscillatory activity: 1) Pyramidal cells negatively shifted
    their preferred theta phases when the light was applied, while interneurons responses
    were less consistent. 2) As a population, pyramidal cells negatively shifted their
    preferred activity during gamma oscillations, albeit we did not find gamma modulation
    differences related to the light application when pyramidal cells were subdivided
    into the disinhibited and unaffected groups. 3) During the peak of SWR events,
    all but the CCK-interneurons had a reduction in their relative firing rate change
    during the light application as compared to the change observed at SWR initiation.
    Finally, regarding to the place field activity of the recorded pyramidal neurons,
    we showed that the disinhibited pyramidal cells had reduced place field similarity,
    coherence and spatial information, but only during the light application. The
    mechanisms behind such observed behaviours might involve eCB signalling and plastic
    changes in CCK-interneuron synapses. In conclusion, the observed changes related
    to the light-mediated silencing of CCKinterneurons have unravelled characteristics
    of this interneuron subpopulation that might change the understanding not only
    of their particular network interactions, but also of the current theories about
    the emergence of certain cognitive processes such as place coding needed for navigation
    or hippocampus-dependent memory consolidation. '
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dámaris K
  full_name: Rangel Guerrero, Dámaris K
  id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
  last_name: Rangel Guerrero
  orcid: 0000-0002-8602-4374
citation:
  ama: Rangel Guerrero DK. The role of CCK-interneurons in regulating hippocampal
    network dynamics. 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6849">10.15479/AT:ISTA:6849</a>
  apa: Rangel Guerrero, D. K. (2019). <i>The role of CCK-interneurons in regulating
    hippocampal network dynamics</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT:ISTA:6849">https://doi.org/10.15479/AT:ISTA:6849</a>
  chicago: Rangel Guerrero, Dámaris K. “The Role of CCK-Interneurons in Regulating
    Hippocampal Network Dynamics.” Institute of Science and Technology Austria, 2019.
    <a href="https://doi.org/10.15479/AT:ISTA:6849">https://doi.org/10.15479/AT:ISTA:6849</a>.
  ieee: D. K. Rangel Guerrero, “The role of CCK-interneurons in regulating hippocampal
    network dynamics,” Institute of Science and Technology Austria, 2019.
  ista: Rangel Guerrero DK. 2019. The role of CCK-interneurons in regulating hippocampal
    network dynamics. Institute of Science and Technology Austria.
  mla: Rangel Guerrero, Dámaris K. <i>The Role of CCK-Interneurons in Regulating Hippocampal
    Network Dynamics</i>. Institute of Science and Technology Austria, 2019, doi:<a
    href="https://doi.org/10.15479/AT:ISTA:6849">10.15479/AT:ISTA:6849</a>.
  short: D.K. Rangel Guerrero, The Role of CCK-Interneurons in Regulating Hippocampal
    Network Dynamics, Institute of Science and Technology Austria, 2019.
corr_author: '1'
date_created: 2019-09-06T06:54:16Z
date_published: 2019-09-09T00:00:00Z
date_updated: 2026-09-03T06:40:36Z
day: '09'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: JoCs
- _id: GradSch
doi: 10.15479/AT:ISTA:6849
doi_confirm: '1'
file:
- access_level: closed
  checksum: 244dc4f74dbfc94f414156092298831f
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: drangel
  date_created: 2019-09-09T13:09:45Z
  date_updated: 2021-02-10T23:30:09Z
  embargo_to: open_access
  file_id: '6865'
  file_name: Thesis_Damaris_Rangel_source.docx
  file_size: 18253100
  relation: source_file
- access_level: open_access
  checksum: 59c73be40eeaa1c4db24067270151555
  content_type: application/pdf
  creator: drangel
  date_created: 2019-09-09T13:09:52Z
  date_updated: 2020-09-11T22:30:04Z
  embargo: 2020-09-10
  file_id: '6866'
  file_name: Thesis_Damaris_Rangel_pdfa.pdf
  file_size: 2160109
  relation: main_file
  request_a_copy: 0
file_date_updated: 2021-02-10T23:30:09Z
fulldoi: https://doi.org/10.15479/AT:ISTA:6849
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '97'
publication_identifier:
  isbn:
  - 978-3-99078-003-9
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '5914'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
title: The role of CCK-interneurons in regulating hippocampal network dynamics
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2019'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19544'
abstract:
- lang: eng
  text: Medicinal bioinorganic chemistry is a thriving field of drug research for
    cancer treatment. Transition metal complexes coordinated to essential biological
    scaffolds represent a highly promising class of compounds for design of novel
    target-specific therapeutics. We report here the biological evaluation of a novel
    Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines
    by assessing their effects on cellular metabolism, real-time cell proliferation
    and induction of apoptosis. Further, the impact of compounds on the p53 protein
    and expression of its target genes, including MDM2, p21/CDKN1A, and PUMA was evaluated.
    Results obtained in this study provide further evidence in support of our prior
    data suggesting the p53-mediated mechanism of action for Isatin-Schiff base derivatives
    and their complexes and also shed light on potential use of these compounds for
    stimulation of apoptosis in breast cancer cells via activation of the pro-apoptotic
    PUMA gene.
article_number: '103'
article_processing_charge: Yes
article_type: original
author:
- first_name: Emil
  full_name: Bulatov, Emil
  last_name: Bulatov
- first_name: Regina
  full_name: Sayarova, Regina
  last_name: Sayarova
- first_name: Rimma
  full_name: Mingaleeva, Rimma
  last_name: Mingaleeva
- first_name: Regina
  full_name: Miftakhova, Regina
  last_name: Miftakhova
- first_name: Marina
  full_name: Gomzikova, Marina
  last_name: Gomzikova
- first_name: Iurii
  full_name: Ignatev, Iurii
  id: 2ac71786-dc7d-11ea-9b2f-c5ad4b9faff6
  last_name: Ignatev
- first_name: Alexey
  full_name: Petukhov, Alexey
  last_name: Petukhov
- first_name: Pavel
  full_name: Davidovich, Pavel
  last_name: Davidovich
- first_name: Albert
  full_name: Rizvanov, Albert
  last_name: Rizvanov
- first_name: Nickolai A.
  full_name: Barlev, Nickolai A.
  last_name: Barlev
citation:
  ama: Bulatov E, Sayarova R, Mingaleeva R, et al. Isatin-Schiff base-copper (II)
    complex induces cell death in p53-positive tumors. <i>Cell Death Discovery</i>.
    2018;4. doi:<a href="https://doi.org/10.1038/s41420-018-0120-z">10.1038/s41420-018-0120-z</a>
  apa: Bulatov, E., Sayarova, R., Mingaleeva, R., Miftakhova, R., Gomzikova, M., Ignatev,
    I., … Barlev, N. A. (2018). Isatin-Schiff base-copper (II) complex induces cell
    death in p53-positive tumors. <i>Cell Death Discovery</i>. Springer Nature. <a
    href="https://doi.org/10.1038/s41420-018-0120-z">https://doi.org/10.1038/s41420-018-0120-z</a>
  chicago: Bulatov, Emil, Regina Sayarova, Rimma Mingaleeva, Regina Miftakhova, Marina
    Gomzikova, Iurii Ignatev, Alexey Petukhov, Pavel Davidovich, Albert Rizvanov,
    and Nickolai A. Barlev. “Isatin-Schiff Base-Copper (II) Complex Induces Cell Death
    in P53-Positive Tumors.” <i>Cell Death Discovery</i>. Springer Nature, 2018. <a
    href="https://doi.org/10.1038/s41420-018-0120-z">https://doi.org/10.1038/s41420-018-0120-z</a>.
  ieee: E. Bulatov <i>et al.</i>, “Isatin-Schiff base-copper (II) complex induces
    cell death in p53-positive tumors,” <i>Cell Death Discovery</i>, vol. 4. Springer
    Nature, 2018.
  ista: Bulatov E, Sayarova R, Mingaleeva R, Miftakhova R, Gomzikova M, Ignatev I,
    Petukhov A, Davidovich P, Rizvanov A, Barlev NA. 2018. Isatin-Schiff base-copper
    (II) complex induces cell death in p53-positive tumors. Cell Death Discovery.
    4, 103.
  mla: Bulatov, Emil, et al. “Isatin-Schiff Base-Copper (II) Complex Induces Cell
    Death in P53-Positive Tumors.” <i>Cell Death Discovery</i>, vol. 4, 103, Springer
    Nature, 2018, doi:<a href="https://doi.org/10.1038/s41420-018-0120-z">10.1038/s41420-018-0120-z</a>.
  short: E. Bulatov, R. Sayarova, R. Mingaleeva, R. Miftakhova, M. Gomzikova, I. Ignatev,
    A. Petukhov, P. Davidovich, A. Rizvanov, N.A. Barlev, Cell Death Discovery 4 (2018).
date_created: 2025-04-11T01:31:42Z
date_published: 2018-11-13T00:00:00Z
date_updated: 2025-07-10T11:51:52Z
day: '13'
ddc:
- '570'
department:
- _id: GradSch
- _id: LoSw
doi: 10.1038/s41420-018-0120-z
extern: '1'
external_id:
  pmid:
  - '30455989 '
fulldoi: https://doi.org/10.1038/s41420-018-0120-z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41420-018-0120-z
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Death Discovery
publication_identifier:
  issn:
  - 2058-7716
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2018'
...
---
_id: '104'
abstract:
- lang: eng
  text: The biotrophic pathogen Ustilago maydis, the causative agent of corn smut
    disease, infects one of the most important crops worldwide – Zea mays. To successfully
    colonize its host, U. maydis secretes proteins, known as effectors, that suppress
    plant defense responses and facilitate the establishment of biotrophy. In this
    work, we describe the U. maydis effector protein Cce1. Cce1 is essential for virulence
    and is upregulated during infection. Through microscopic analysis and in vitro
    assays, we show that Cce1 is secreted from hyphae during filamentous growth of
    the fungus. Strikingly, Δcce1 mutants are blocked at early stages of infection
    and induce callose deposition as a plant defense response. Cce1 is highly conserved
    among smut fungi and the Ustilago bromivora ortholog complemented the virulence
    defect of the SG200Δcce1 deletion strain. These data indicate that Cce1 is a core
    effector with apoplastic localization that is essential for U. maydis to infect
    its host.
acknowledgement: 'the Austrian Science Fund (FWF): [P27429‐B22, P27818‐B22, I 3033‐B22],
  and the Austrian Academy of Science (OEAW).'
article_processing_charge: No
author:
- first_name: Denise
  full_name: Seitner, Denise
  last_name: Seitner
- first_name: Simon
  full_name: Uhse, Simon
  last_name: Uhse
- first_name: Michelle C
  full_name: Gallei, Michelle C
  id: 35A03822-F248-11E8-B48F-1D18A9856A87
  last_name: Gallei
  orcid: 0000-0003-1286-7368
- first_name: Armin
  full_name: Djamei, Armin
  last_name: Djamei
citation:
  ama: Seitner D, Uhse S, Gallei MC, Djamei A. The core effector Cce1 is required
    for early infection of maize by Ustilago maydis. <i>Molecular Plant Pathology</i>.
    2018;19(10):2277-2287. doi:<a href="https://doi.org/10.1111/mpp.12698">10.1111/mpp.12698</a>
  apa: Seitner, D., Uhse, S., Gallei, M. C., &#38; Djamei, A. (2018). The core effector
    Cce1 is required for early infection of maize by Ustilago maydis. <i>Molecular
    Plant Pathology</i>. Wiley. <a href="https://doi.org/10.1111/mpp.12698">https://doi.org/10.1111/mpp.12698</a>
  chicago: Seitner, Denise, Simon Uhse, Michelle C Gallei, and Armin Djamei. “The
    Core Effector Cce1 Is Required for Early Infection of Maize by Ustilago Maydis.”
    <i>Molecular Plant Pathology</i>. Wiley, 2018. <a href="https://doi.org/10.1111/mpp.12698">https://doi.org/10.1111/mpp.12698</a>.
  ieee: D. Seitner, S. Uhse, M. C. Gallei, and A. Djamei, “The core effector Cce1
    is required for early infection of maize by Ustilago maydis,” <i>Molecular Plant
    Pathology</i>, vol. 19, no. 10. Wiley, pp. 2277–2287, 2018.
  ista: Seitner D, Uhse S, Gallei MC, Djamei A. 2018. The core effector Cce1 is required
    for early infection of maize by Ustilago maydis. Molecular Plant Pathology. 19(10),
    2277–2287.
  mla: Seitner, Denise, et al. “The Core Effector Cce1 Is Required for Early Infection
    of Maize by Ustilago Maydis.” <i>Molecular Plant Pathology</i>, vol. 19, no. 10,
    Wiley, 2018, pp. 2277–87, doi:<a href="https://doi.org/10.1111/mpp.12698">10.1111/mpp.12698</a>.
  short: D. Seitner, S. Uhse, M.C. Gallei, A. Djamei, Molecular Plant Pathology 19
    (2018) 2277–2287.
date_created: 2018-12-11T11:44:39Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2023-09-19T10:06:42Z
day: '01'
ddc:
- '580'
department:
- _id: GradSch
doi: 10.1111/mpp.12698
external_id:
  isi:
  - '000445624100006'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:46:00Z
  date_updated: 2018-12-18T09:46:00Z
  file_id: '5740'
  file_name: 2018_MolecPlantPath_Seitner.pdf
  file_size: 682335
  relation: main_file
  success: 1
file_date_updated: 2018-12-18T09:46:00Z
fulldoi: https://doi.org/10.1111/mpp.12698
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 2277 - 2287
publication: Molecular Plant Pathology
publication_status: published
publisher: Wiley
publist_id: '7950'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The core effector Cce1 is required for early infection of maize by Ustilago
  maydis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
OA_place: publisher
_id: '69'
abstract:
- lang: eng
  text: 'A qubit, a unit of quantum information, is essentially any quantum mechanical
    two-level system which can be coherently controlled. Still, to be used for computation,
    it has to fulfill criteria. Qubits, regardless of the system in which they are
    realized, suffer from decoherence. This leads to loss of the information stored
    in the qubit. The upper bound of the time scale on which decoherence happens is
    set by the spin relaxation time. In this thesis I studied a two-level system consisting
    of a Zeeman-split hole spin confined in a quantum dot formed in a Ge hut wire.
    Such Ge hut wires have emerged as a promising material system for the realization
    of spin qubits, due to the combination of two significant properties: long spin
    coherence time as expected for group IV semiconductors due to the low hyperfine
    interaction and a strong valence band spin-orbit coupling. Here, I present how
    to fabricate quantum dot devices suitable for electrical transport measurements.
    Coupled quantum dot devices allowed the realization of a charge sensor, which
    is electrostatically and tunnel coupled to a quantum dot. By integrating the charge
    sensor into a radio-frequency reflectometry setup, I performed for the first time
    single-shot readout measurements of hole spins and extracted the hole spin relaxation
    times in Ge hut wires.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lada
  full_name: Vukušić, Lada
  id: 31E9F056-F248-11E8-B48F-1D18A9856A87
  last_name: Vukušić
  orcid: 0000-0003-2424-8636
citation:
  ama: Vukušić L. Charge sensing and spin relaxation times of holes in Ge hut wires.
    2018. doi:<a href="https://doi.org/10.15479/AT:ISTA:TH_1047">10.15479/AT:ISTA:TH_1047</a>
  apa: Vukušić, L. (2018). <i>Charge sensing and spin relaxation times of holes in
    Ge hut wires</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:TH_1047">https://doi.org/10.15479/AT:ISTA:TH_1047</a>
  chicago: Vukušić, Lada. “Charge Sensing and Spin Relaxation Times of Holes in Ge
    Hut Wires.” Institute of Science and Technology Austria, 2018. <a href="https://doi.org/10.15479/AT:ISTA:TH_1047">https://doi.org/10.15479/AT:ISTA:TH_1047</a>.
  ieee: L. Vukušić, “Charge sensing and spin relaxation times of holes in Ge hut wires,”
    Institute of Science and Technology Austria, 2018.
  ista: Vukušić L. 2018. Charge sensing and spin relaxation times of holes in Ge hut
    wires. Institute of Science and Technology Austria.
  mla: Vukušić, Lada. <i>Charge Sensing and Spin Relaxation Times of Holes in Ge Hut
    Wires</i>. Institute of Science and Technology Austria, 2018, doi:<a href="https://doi.org/10.15479/AT:ISTA:TH_1047">10.15479/AT:ISTA:TH_1047</a>.
  short: L. Vukušić, Charge Sensing and Spin Relaxation Times of Holes in Ge Hut Wires,
    Institute of Science and Technology Austria, 2018.
corr_author: '1'
date_created: 2018-12-11T11:44:28Z
date_published: 2018-09-01T00:00:00Z
date_updated: 2026-04-08T14:09:47Z
day: '01'
ddc:
- '530'
- '600'
degree_awarded: PhD
department:
- _id: GeKa
- _id: GradSch
doi: 10.15479/AT:ISTA:TH_1047
file:
- access_level: open_access
  checksum: c570b656e30749cd65b1c7e13a9ce0a8
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-09T07:00:40Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6247'
  file_name: 2018_Thesis_Vukusic.pdf
  file_size: 28452385
  relation: main_file
- access_level: closed
  checksum: 7856771d9cd401fe0b311191076db6e1
  content_type: application/zip
  creator: dernst
  date_created: 2019-04-09T07:00:40Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6248'
  file_name: 2018_Thesis_Vukusic_source.zip
  file_size: 53058704
  relation: source_file
file_date_updated: 2020-07-14T12:47:44Z
fulldoi: https://doi.org/10.15479/AT:ISTA:TH_1047
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '103'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '7985'
pubrep_id: '1047'
related_material:
  record:
  - id: '23'
    relation: part_of_dissertation
    status: public
  - id: '840'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Georgios
  full_name: Katsaros, Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
title: Charge sensing and spin relaxation times of holes in Ge hut wires
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2018'
...
