@article{21749, abstract = {The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order structures remain unclear. Here, we incorporate cation−π and electrostatic charge pairs to probe interhelical interactions and elucidate the mechanisms driving triple helix assembly into fibrils, nanotubes, and nanosheets. Introducing cation−π pairs into a fibrillating collagen mimetic resulted in D-periodic fibrils with pH-sensitive gelation. By alternating the presentation of electrostatic and cation−π pairs, the assembly of another D-periodic fibril featuring inner and outer triple-helical layers was resolved by cryo electron microscopy to a resolution of 8 Å. At physiological pH, antiparallel association of these triple helices leads to the formation of nanotubes. The packing behavior of triple helices correlates with the interhelical interactions, where parallel associations favor fibril formation and antiparallel interactions drive nanotube and nanosheet assembly. These self-assembling triple-helical peptides demonstrate how packing of higher-order structures can be tailored with supramolecular interactions and establish the relationship of different hierarchical collagen-mimetic assemblies as pH-dependent.}, author = {Cole, Carson C. and Kreutzberger, Mark A.B. and Klein, Kevin and Cahue, Kiana A. and Pogostin, Brett H. and Farsheed, Adam C. and Swain, Joseph W.R. and Bui, Thi H. and Dey, Arghadip and Makhoul, Jonathan T. and Dubackic, Marija and Pal, Antara and Olsson, Ulf and Šarić, Anđela and Egelman, Edward H. and Hartgerink, Jeffrey D.}, issn = {1526-4602}, journal = {Biomacromolecules}, number = {4}, pages = {2956--2965}, publisher = {American Chemical Society}, title = {{Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies}}, doi = {10.1021/acs.biomac.6c00345}, volume = {27}, year = {2026}, } @article{21750, abstract = {Liquid-like superionic conductors, with highly mobile ions in a rigid framework, offer intrinsically low lattice thermal conductivity without compromising electronic transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its low carrier concentration limits the power factor. Here, interstitial Ag atoms raise the Fermi level into the conduction band, substantially increasing the electron concentration. Simultaneously, the formation of a secondary Ag2Se phase generates lattice distortions that enhance phonon scattering. A pronounced mismatch between electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples charge and heat transport, enabling concurrent suppression of κL and retention of high electrical conductivity. This coupled electronic-phononic modulation yields a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins, with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves 6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy for high-performance midtemperature thermoelectrics.}, author = {Li, Mengyao and Zhao, Xueke and Zhang, Yu and Yu, Jing and Liu, Xuyang and Jia, Mochen and Song, Hongzhang and Wang, Dongyang and Arbiol, Jordi and Ibáñez, Maria and Shan, Chongxin and Cabot, Andreu and Wang, Ziyu}, issn = {2375-2548}, journal = {Science Advances}, number = {15}, publisher = {AAAS}, title = {{Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6}}, doi = {10.1126/sciadv.aec9073}, volume = {12}, year = {2026}, } @article{21752, abstract = {Epithelial tissues function as multicellular communities that preserve tissue integrity while adapting to diverse environmental stresses by altering cell behaviors. A striking manifestation of such adaptability is cell plasticity, the ability of differentiated cells to revert to stem-like states or adopt alternative fates. Once considered rare and confined to highly regenerative species, cell plasticity is now recognized across the metazoan tree. In early-branching animals such as sponges and cnidarians, transdifferentiation and dedifferentiation are integral to life-cycle transitions and regeneration, whereas in more complex organisms, these processes typically emerge under stress, including stem cell loss or environmental perturbations. Here, we examine epithelial cell plasticity through evolutionary, cellular, and molecular perspectives. Focusing on the intestinal epithelium, we explore findings from mammalian and Drosophila models showing that progenitors and even terminally differentiated cells can dedifferentiate in response to external stimuli that disrupt homeostasis, such as pathogen infection and nutrient fluctuations. We further discuss conserved mechanisms involving intercellular signaling (e.g., Notch, EGFR, and JAK-STAT) and chromatin states primed for reprogramming, modulated by metabolic cues. Together, these insights position cell plasticity as an ancient environmental adaptation strategy, shaped by conserved molecular toolkits and refined by species- and cell lineage-specific innovations.}, author = {Nagai, Hiroki and Nakajima, Yu Ichiro}, issn = {1096-3634}, journal = {Seminars in Cell and Developmental Biology}, publisher = {Elsevier}, title = {{Epithelial cell plasticity in metazoans: Evolutionary insights into roles and mechanisms}}, doi = {10.1016/j.semcdb.2026.103670}, volume = {179-180}, year = {2026}, } @article{21755, abstract = {Tropical shallow clouds are a major source of uncertainty in Earth's climate sensitivity, especially through their spatial arrangement, which global climate models do not represent. Efforts to understand their organization have partly relied on classifying observed scenes, identifying four patterns as archetypal regimes. Here we analyze geostationary satellite imagery of the western tropical Atlantic using the L‐function, a tool based on point pattern theory that quantifies cloud organization across spatial scales. Classical examples of the four patterns show distinct L‐function fingerprints, revealing their characteristic clustering and regularity scales and aiding physical interpretation. Yet, when evaluating many scenes at fixed spatial scales, the L‐function distribution lacks the distinct modes expected from discrete regimes. This is corroborated by analyses of other organization indices employing diverse approaches, from inter‐cloud nearest‐neighbor distances to fractal analysis. Implications for the parameterization of mesoscale cloud organization in climate models are discussed.}, author = {Biagioli, Giovanni and Mandorli, Giulio and Freischem, Lilli Johanna and Casallas Garcia, Alejandro and Tompkins, Adrian Mark}, issn = {1944-8007}, journal = {Geophysical Research Letters}, number = {8}, publisher = {Wiley}, title = {{Spatial patterns of shallow clouds: Challenging the concept of defined regimes}}, doi = {10.1029/2025gl119921}, volume = {53}, year = {2026}, } @article{21760, abstract = {3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential origin and a perturber to its orbit. We integrated the orbit of 3I/ATLAS backward in time for 10 Myr, together with a sample of Gaia DR3 stars with high-quality astrometry and radial velocities, to identify close passages within 2 pc. We identify 93 nominal encounters, 62 of which are significant at the 2σ level. However, none of these encounters produced any meaningful perturbation. The strongest perturber Gaia DR3 6863591389529611264 at 0.30 pc and with a relative velocity of 35 km s−1, imparted only a velocity change of ∣Δv∣ ≃ 5 × 10−4 km s−1 to the orbit of 3I/ATLAS. Our results indicate that no stellar flybys within the past 10 Myr and 500 pc contained in Gaia DR3 can account for the present trajectory of 3I/ATLAS or be associated with its origin. We further show that 3I/ATLAS is kinematically consistent with a thin-disk population, despite its large peculiar velocity.}, author = {Pérez-Couto, X. and Torres Rodriguez, Santiago and Villaver, E. and Mustill, A. J. and Manteiga, M.}, issn = {1538-4357}, journal = {The Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{3I/ATLAS: In search of the witnesses to its voyage}}, doi = {10.3847/1538-4357/ae56ff}, volume = {1001}, year = {2026}, } @article{21764, abstract = {Colloidal fluids can exhibit complex phase behavior and determining phase diagrams via experiments or computer simulations can be laborious. We demonstrate that the dispersion relation ω(k), obtained from dynamical density functional theory for the uniform density system, is a highly versatile tool for predicting where in the phase diagram complex crystals form. The sign of ω(k) determines whether density modes with wave number k grow or decay over time. We demonstrate the predictive power by investigating the complex phase behavior of particles interacting via core-shoulder pair potentials. With complementary Monte Carlo simulations, we show that regions of the phase diagram where ωðkÞ has one or several unstable (growing) wave numbers are also where crystalline phases occur. Going further, by tuning these unstable wave numbers via the interaction-potential and state-point parameters, we design systems with quasicrystals in the phase diagram. We identify a system with a certain shoulder range exhibiting at least ten different phases. Our general approach accelerates considerably the mapping of complex phase diagrams, crucial for the design of new materials.}, author = {Wassermair, Michael and Kahl, Gerhard and Roth, Roland and Archer, Andrew J.}, issn = {1079-7114}, journal = {Physical Review Letters}, number = {14}, publisher = {American Physical Society}, title = {{Navigating complex phase diagrams in soft matter systems}}, doi = {10.1103/nbvt-fgjy}, volume = {136}, year = {2026}, } @article{21765, abstract = {Dielectric particles of the same material exchange electrical charge during collisions or sliding contacts, yet the underlying charge-exchange mechanism is still not understood. The fact that particles can become highly charged as a result of this effect has significant consequences for many settings, both in nature and industry, such as thunderstorms, volcanic eruptions, particle aggregation during meteorite and planet formation, and the clogging of industrial granular systems. Toward understanding these systems, great efforts have been made to develop precise in situ measurements for particle charge, e.g., to determine ensemble charge distributions or measure exchange during individual contacts. Here, we present experimental results concerning the particle size scaling of the stationary-state charge distributions of oxide particles in the sub-millimeter range. We measure the charge distributions for large ensembles of monodisperse ZrO2:SiO2 composite spheres, ranging from 172 to 545µ⁢m in diameter. These distributions are non-Gaussian and collapse to a single master curve when plotted as functions of the surface charge density Σ=𝑞/4⁢𝜋⁢𝑅2. X-ray fluorescence and atomic force microscopy measurements show that the differences in the measured charge distributions are not due to variations in chemical composition or surface roughness, but rather to size alone. Our findings provide constraints on microscopic models for charge exchange, namely that they should lead to steady-state distributions that are non-Gaussian and scale in a specific way with particle size.}, author = {Lara, Macarena and Flores, Marcos and Castillo, Gustavo and Tassara, Santiago and Waitukaitis, Scott R and Mujica, Nicolás}, issn = {2475-9953}, journal = {Physical Review Materials}, number = {4}, publisher = {American Physical Society}, title = {{Particle size scaling of non-Gaussian granular charge distributions}}, doi = {10.1103/qw6t-xqdw}, volume = {10}, year = {2026}, } @article{21766, abstract = {We provide a new characterisation of the decades old open problem of extending bilipschitz mappings given on a Euclidean separated net. In particular, this allows for the complete positive solution of the open problem in dimension two. Along the way, we develop a set of tools for bilipschitz extensions of mappings between subsets of Euclidean spaces.}, author = {Dymond, Michael and Kaluza, Vojtech}, issn = {2737-114X}, journal = {Annales Fennici Mathematici}, keywords = {Lipschitz, bilipschitz, extension, separated net.}, number = {1}, pages = {237--260}, publisher = {Finnish Mathematical Society}, title = {{Extending bilipschitz mappings between separated nets}}, doi = {10.54330/afm.181562}, volume = {51}, year = {2026}, } @article{21767, abstract = {The involvement of non-scientific staff in discussions about animal welfare and scientific quality is essential for biomedical research progress. In this study, we developed a survey to collect the self-perception of animal care staff (ACS) and laboratory technicians about their involvement in scientific planning and conduct. Participants were contacted to complete an anonymous online questionnaire. We obtained 850 responses, mainly from Europe: 564 from ACS and 286 from laboratory technicians. Job satisfaction was assessed as positive by ACS and laboratory technicians despite the low frequency of culture of care activities and mental health meetings. Both groups expressed their desire to be trained in research planning and conduct; however, regular training was not reported. In addition, the inability to act on animal welfare concerns owing to experimental reasons was reported by both groups. Over half of the participants felt valued and appreciated by the lead scientists or animal facility manager; however, it is not clear how they are acknowledged, as their names on the authors list or in the manuscript acknowledgments are barely included. Our results indicated that involvement of ACS and laboratory technicians in planning and conducting studies would improve their understanding of how experiments are done, and therefore communication processes, work satisfaction, animal welfare, and scientific quality. Finally, we provided recommendations to improve the engagement of ACS and laboratory technicians in discussions about animal research planning and conduct.}, author = {Gonzalez-Uarquin, Fernando and Jirkof, Paulin and Bert, Bettina and Hawkins, Penny and Angelovski, Ljupco and Baumgart, Jan and Baumgart, Nadine and Cevik, Özge S. and Franco, Nuno H. and Horata, Erdal and Kaura, Rohish and Neuhaus, Winfried and Riso, Brigida and Smith, Adrian J. and Sotiropoulos, Athanassia and Vitale, Augusto and Schober, Sophie}, issn = {1758-1117}, journal = {Laboratory Animals}, publisher = {SAGE Publications}, title = {{Building bridges: Involvement of animal care staff and laboratory technicians in experimental planning and conduct of animal studies for better job satisfaction and science}}, doi = {10.1177/00236772251400976}, year = {2026}, } @article{21776, abstract = {Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications.}, author = {Petrik, Adam and Bena, Aleksander and Baunis, Haralds and Kelch, Riley M. and Yoon, Tehshik P. and Pieber, Bartholomäus}, issn = {1615-4169}, journal = {Advanced Synthesis & Catalysis}, number = {9}, publisher = {Wiley}, title = {{Facile access to N-substituted pyridyl ligands}}, doi = {10.1002/adsc.70417}, volume = {368}, year = {2026}, } @article{21778, abstract = {We prove that every 𝐿-bilipschitz mapping ℤ 2 → ℝ2 canbe extended to a 𝐶(𝐿)-bilipschitz mapping ℝ2 → ℝ2,and we provide a polynomial upper bound for 𝐶(𝐿).Moreover, we extend the result to every separated netin ℝ2 instead of ℤ 2, with the upper bound gaininga polynomial dependence on the separation and netconstants associated to the given separated net. Thisanswers an Oberwolfach question of Navas from 2015and is also a positive solution of the two-dimensionalform of a decades old open (in all dimensions at leasttwo) problem due to Alestalo Trotsenko and Väisälä.}, author = {Dymond, Michael and Kaluza, Vojtech}, issn = {1469-7750}, journal = {Journal of the London Mathematical Society}, number = {4}, publisher = {Wiley}, title = {{Planar bilipschitz extension from separated nets}}, doi = {10.1112/jlms.70540}, volume = {113}, year = {2026}, } @article{21779, abstract = {Acidomycin is an anti-mycobacterial antibiotic with a unique mode of action, targeting the biotin biosynthesis pathway. Despite being highly active against mycobacteria in vitro, its development as an anti-tubercular agent has been hindered due to suboptimal pharmacokinetics. Engineering of the acidomycin biosynthesis may yield new analogues with improved pharmacological properties. Here, we describe the identification of the acidomycin biosynthetic gene cluster (BGC) in a Streptomyces bacterium isolated from the rhizosphere of Edelweiss. Notably, the acidomycin BGC is located in proximity to the genes for the biosynthesis of stravidins, secondary metabolites targeting a different enzyme in the biotin biosynthesis pathway, and two genes for streptavidins, proteins that strongly bind and sequester biotin. The identity of the acidomycin BGC was confirmed via both gene knock-out and heterologous expression, which suggested that the fatty acid required for the formation of acidomycin's acyl chain is most likely scavenged from the biotin biosynthesis pathway. CRISPR/Cas9-assisted knock-out of the cytochrome P450-encoding gene in the acidomycin BGC resulted in a significant decrease in its yield but did not abrogate the biosynthesis completely.}, author = {Vignolle, Anna and Zehl, Martin and Garzón, Jaime Felipe Guerrero and Schneider, Olha and Gafriller, Johannes and Grienke, Ulrike and Kirkegaard, Rasmus H. and Zotchev, Sergey B.}, issn = {1751-7915}, journal = {Microbial Biotechnology}, number = {4}, publisher = {Wiley}, title = {{Identification and characterisation of the gene cluster governing biosynthesis of the anti-mycobacterial antibiotic acidomycin}}, doi = {10.1111/1751-7915.70357}, volume = {19}, year = {2026}, } @article{21780, abstract = {It is predicted that half or more of all cataclysmic variables (CVs) should have evolved past the period minimum and now exist as so-called period bouncers where a white dwarf should be accreting from a Roche lobe filling substellar companion. However, this prediction stands in stark contrast to observations, where only a few per cent of CVs are found in this evolutionary phase. A potential solution to this discrepancy is that a magnetic field emerges from within the white dwarf after the system has reached the period minimum. The transfer of angular momentum from the spin of the white dwarf into the orbit then pushes the two stars apart, detaching them for potentially billions of years. Here we present the discovery of ZTF J021804.16+071152.93, a detached 0.69 +- 0.01 M⁠, 19 MG magnetic white dwarf plus 37 +- 5MJup brown dwarf binary with an orbital period of 1.7 h. The kinematics of the system indicate that it is a high probability member of the Galactic thick disc. However, this strongly disagrees with the much younger age of the system obtained from the white dwarf parameters, implying that the system may have been accreting in the past. This system is therefore consistent with having detached as a result of the emergence of the magnetic field of the white dwarf when the system was still mass transferring, and may represent the ultimate fate for many (perhaps even most) CVs.}, author = {Parsons, S. G. and Brown, A. J. and Casewell, S. L. and Littlefair, S. P. and van Roestel, Joannes C and Rebassa-Mansergas, A. and Murillo-Ojeda, R. and Zorotovic, M. and Schreiber, M. R. and Bagnulo, S. and Stroet, M. A. and Castro Segura, N. and Dhillon, V. S. and Dyer, M. J. and Garbutt, J. A. and Green, M. J. and Jarvis, D. and Kennedy, M. R. and Kerry, P. and Mccormac, J. and Munday, J. and Pelisoli, I. and Pike, E. and Sahman, D. I. and Yates, A.}, issn = {1365-2966}, journal = {Monthly Notices of the Royal Astronomical Society}, number = {4}, publisher = {Oxford University Press}, title = {{ZTF J021804.16+071152.93: A dead cataclysmic variable and potential solution to the missing period bouncer cataclysmic variables}}, doi = {10.1093/mnras/stag521}, volume = {547}, year = {2026}, } @article{21781, abstract = {Given a set A of n points (vertices) in general position in the plane, the complete geometric graph Kn[A] consists of all (n2) segments (edges) between the elements of A. It is known that the edge set of every complete geometric graph on n vertices can be partitioned into O(n3∕2) crossing-free paths (or matchings). We strengthen this result under various additional assumptions on the point set. In particular, we prove that for a set A of n randomly selected points, uniformly distributed in [0,1]2, with probability tending to 1 as n→∞, the edge set of Kn[A] can be covered by O(nlogn) crossing-free paths and by O(n√logn) crossing-free matchings. On the other hand, we construct n-element point sets such that covering the edge set of Kn[A] requires a quadratic number of monotone paths.}, author = {Dumitrescu, Adrian and Pach, János and Saghafian, Morteza and Scott, Alex}, issn = {2996-220X}, journal = {Combinatorics and Number Theory}, number = {1}, pages = {73--82}, publisher = {Mathematical Sciences Publishers}, title = {{Covering complete geometric graphs by monotone paths}}, doi = {10.2140/cnt.2026.15.73}, volume = {15}, year = {2026}, } @misc{21800, abstract = {LAMMPS input scripts to simulate toroidal vesicles composed of pure bolalipid membranes and archaeal mixture membranes for the following publication: "Cracking donuts and sorting lipids: geometry controls archaeal membrane stability and lipid organization" by Felix Frey, Miguel Amaral, and Andela Saric.}, author = {Frey, Felix F and Santana de Freitas Amaral, Miguel and Šarić, Anđela}, publisher = {Zenodo}, title = {{Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization}}, doi = {10.5281/ZENODO.18772086}, year = {2026}, } @article{21837, abstract = {In a warming world of glacier changes, the scientific community has dedicated increasing attention to debris-covered glaciers and their response to climate. A variety of models with distinct complexity and data requirements have been developed and widely used to simulate melt under debris at different sites and scales, but their skills have never been compared. As part of the activities of the International Association of Cryospheric Sciences (IACS) Debris Covered Glacier Working Group, we present an intercomparison exercise aimed at advancing our understanding of model skills in simulating ice melt under a debris layer. We compare 15 models with different complexity at nine sites in the European Alps, Caucasus, Chilean Andes, Nepalese Himalaya and the Southern Alps of New Zealand, over one melt season. We run the models with measured meteorological data from automatic weather stations and estimated or measured debris properties. We consider four main model categories: (i) energy balance models that calculate melt by solving the physics of heat transfer to the debris layer, but require a high amount of input data; (ii) a simplified energy balance model; (iii) enhanced temperature-index models; and (iv) simple empirical temperature-index models that have been extensively used given their low data requirement but require calibration of their empirical parameters. Model performance is evaluated using on-site measurements of sub-debris melt (for all models) and surface temperature (for models based on the surface energy balance). Our results show that physically-based energy balance models and empirical temperature-index models perform in a distinct manner. At one end of the spectrum, simple temperature-index models are accurate when recalibrated or when using site-specific literature parameters, and show poor results when parameters are uncalibrated. At the other end, energy balance models show a range of performance: the most accurate energy balance models are those with the highest degree of complexity at the atmosphere-debris interface. An important data gap emerged from our experiment: the poor performance of all models at three sites was related to the poor knowledge of debris properties, and specifically of thermal conductivity. Future work should focus on both: (i) consistent data acquisition to evaluate existing models and support new model developments; (ii) advancing models by accounting for processes such as debris-snow interactions, moisture in the debris and refreezing. We suggest that a systematic effort of model development using a common model framework could be carried out in phase II of the Working Group.}, author = {Pellicciotti, Francesca and Fontrodona-Bach, Adrià and Rounce, David R. and Fyffe, Catriona Louise and Anderson, Leif S. and Ayala, Álvaro and Brock, Ben W. and Buri, Pascal and Fugger, Stefan and Fujita, Koji and GANTAYAT, PRATEEK and Groos, Alexander R. and Immerzeel, Walter and Kneib, Marin and Mayer, Christoph and MacDonell, Shelley and McCarthy, Michael and McPhee, James and Miles, Evan and Purdie, Heather and Rets, Ekaterina and Sakai, Akiko and Shaw, Thomas and Steiner, Jakob and Wagnon, Patrick and Winter-Billington, Alex}, issn = {1994-0424}, journal = {The Cryosphere}, number = {3}, pages = {1895--1928}, publisher = {Copernicus Publications}, title = {{DCG-MIP: The debris-covered glacier melt model intercomparison experiment}}, doi = {10.5194/tc-20-1895-2026}, volume = {20}, year = {2026}, } @article{21838, abstract = {We explore the use of a photoacid in a chemical reaction cycle, which allows for the controlled sol‐to‐gel transition of a saccharide aldehyde‐based self‐assembling system. The modulation of the pH with light enables to generate chemical fuels in situ, thus triggering monomer activation and gelation. Our efforts represent a promising step toward dissipative self‐assembled systems with a higher degree of spatiotemporal control.}, author = {Lopez‐Acosta, Alvaro and Valera, Jorge S. and Klajn, Rafal and Hermans, Thomas M.}, issn = {2570-4206}, journal = {ChemSystemsChem}, number = {3}, publisher = {Wiley}, title = {{Photoacid‐mediated controllable gelation in a chemical reaction cycle}}, doi = {10.1002/syst.70037}, volume = {8}, year = {2026}, } @article{21840, abstract = {The transport properties of nanofluidic channels are usually studied under constant (DC) voltage or pressure driving. However, the frequency response under sinusoidal (AC) drivings offers rich insights into the time-dependent transport mechanisms. Inspired by recent electrochemical approaches, we investigate the couplings between ionic and electronic transport under AC driving. We show that conduction electrons of the channel walls participate in ionic current via capacitive electrochemical coupling, defining a critical frequency and length scale where electron-dominated conductivity emerges. We further analyze how electron–ion coupling modifies electro-osmotic flows and demonstrate that fluctuation-induced momentum transfer between the electrolyte and wall electrons produces distinct AC transport signatures, depending on the charge carrier polarity. Altogether, we establish a frequency-dependent transport matrix that couples ionic, electronic, and hydrodynamic flows. These findings establish AC nanofluidic transport as a powerful probe of interfacial phenomena under confinement and suggest new directions for engineering nanofluidic functionalities through electron–electrolyte coupling.}, author = {Coquinot, Baptiste and Lizée, Mathieu and Bocquet, Lydéric and Kavokine, Nikita}, issn = {1089-7690}, journal = {The Journal of Chemical Physics}, number = {13}, publisher = {AIP Publishing}, title = {{Electron–electrolyte coupling in AC transport through nanofluidic channels}}, doi = {10.1063/5.0313352}, volume = {164}, year = {2026}, } @article{21841, abstract = {The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the life sciences and public understanding, with implications for policy and funding priorities. Yet this paradigm is increasingly recognized as inadequate for explaining continuous phenotypic variation and the complex genetic architectures of the genotype–phenotype map. Modern genetics emerged from the early 20th-century synthesis of Mendelian and biometric schools of heredity, with R.A. Fisher demonstrating early on how multiple discrete loci could collectively produce continuous variation. Despite this fundamental insight, Mendelism—with its focus on single genes and standardized genetic backgrounds—became the dominant framework, shaping current genetics research and molecular biology as well as science education. The advent of large-scale genomic data has revealed yet again the limitations of this reductionist approach. Evidence from quantitative genetics now shows that most phenotypes arise from complex networks of many interdependent genes and their dynamic responses to environmental perturbations. Here we trace the historical roots of how Mendelian classical genetics departed from the biometric school to create the current predominant paradigm in genetics, despite fundamentally unresolved issues. Moving on from this one-sided paradigm will require systematic development of integrative, evolutionarily grounded experimental approaches that better capture the multigenic and context-dependent nature of inheritance. Achieving such an extended perspective will require methodological innovation, including advances in large-scale (e.g. automated) phenotyping. Dedicated research programs will be necessary to advance a new era of genetic research into the complex mechanisms underlying phenotypic variation.}, author = {Tautz, Diethard and Pallares, Luisa F and Andersson, Leif and Barghi, Neda and Barton, Nicholas H and Bay, Rachael and Chan, Yingguang Frank and Hancock, Angela and Kaiser, Tobias S and Koenig, Daniel and Kontarakis, Zacharias and Liedvogel, Miriam and de Meaux, Juliette and Nordborg, Magnus and Palmer, Abraham A and Purugganan, Michael and Schlötterer, Christian and Schmid, Karl and Stainier, Didier Y R and Weigel, Detlef and Wolf, Jochen B W and Ebert, Dieter and Gibson, Greg}, issn = {1943-2631}, journal = {Genetics}, keywords = {classic genetics, quantitative genetics, genotype–phenotype map}, number = {4}, publisher = {Oxford University Press}, title = {{Beyond Mendel: A call to revisit the genotype–phenotype map through new experimental paradigms}}, doi = {10.1093/genetics/iyag024}, volume = {232}, year = {2026}, } @article{21842, abstract = {AM CVn stars are ultra-compact semi-detached binaries consisting of a white dwarf primary and a hydrogen-depleted secondary. In this paper, we present spectroscopic and photometric results of 15 transient sources pre-classified as AM CVn candidates. Our analysis confirms 9 systems of the type AM CVn, 3 hydrogen-rich cataclysmic variables (accreting white dwarfs with near-main-sequence stars for donors), and 3 systems that could be evolved cataclysmic variables. Eight of the AM CVn stars are analysed spectroscopically for the first time, which increases the number of spectroscopically confirmed AM CVns by about 10%. TESS data revealed the orbital period of the AM CVn star ASASSN-20pv to be Porb =27.282 min, which helps to constrain the possible values of its mass ratio. TESS also helped to determine the superhump periods of one AM CVn star (ASASSN-19ct, Psh =30.94 min) and two cataclysmic variables we classify as WZ Sge stars (Psh =90.77 min for ZTF18aaaasnn and Psh =91.6min for ASASSN-15na).We identified very different abundances in the spectra of theAM CVns binaries ASASSN-15kf and ASASSN-20pv (both Porb ∼27.5min), suggesting different type of donors. Six of the studied AMCVns are X-ray sources, which helped to determine their mass accretion rates. Photometry shows that the duration of all the superoutbursts detected in the AM CVns is consistent with expectations from the disc instability model. Finally, we provide refined criteria for the identification of new systems using all-sky surveys such as LSST.}, author = {Kára, Jan and Rivera Sandoval, Liliana and Mendoza, Wendy and Maccarone, Thomas and Pichardo Marcano, Manuel and Salazar Manzano, Luis E. and Oelkers, Ryan J. and van Roestel, Joannes C}, issn = {1448-6083}, journal = {Publications of the Astronomical Society of Australia}, publisher = {Cambridge University Press}, title = {{A study of transients from ground-based surveys reveals new ultra-compact accreting white dwarf binaries}}, doi = {10.1017/pasa.2026.10184}, volume = {43}, year = {2026}, }