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Springer Nature. https://doi.org/10.1038/s41467-025-66175-z"},"day":"01","_id":"18892","supplementarymaterial":"no","DOAJ_listed":"1","OA_place":"publisher","acknowledgement":"We thank Joergen Eilenberg and Nicolai V. Meyling for the fungal strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant collection. We also thank the Social Immunity team, in particular David Moreno Martínez, Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular support, as well as Friedrich Fochler for technical support with the chemical analysis, and the ISTA Lab Support Facility, including the mass spectrometry unit, for general and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull and Michael Sixt for project discussion, and the Social Immunity team for comments on the manuscript. The study was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation Programme (No. 771402; EPIDEMICSonCHIP) to SC.","corr_author":"1","title":"Altruistic disease signalling in ant colonies","status":"public","abstract":[{"text":"Sick individuals often conceal their disease status to group members, thereby preventing social exclusion or aggression. Here we show by behavioural, chemical, immunological and infection load analyses that sick ant pupae instead actively emit a chemical signal that in itself is sufficient to trigger their own destruction by colony members. In our experiments, this altruistic disease-signalling was performed only by worker but not queen pupae. The lack of signalling by queen pupae did not constitute cheating behaviour, but reflected their superior immune capabilities. Worker pupae suffered from extensive pathogen replication whereas queen pupae were able to restrain their infection. Our data suggest the evolution of a finely-tuned signalling system in which it is not the induction of an individual’s immune response, but rather its failure to overcome the infection, that triggers pupal signalling for sacrifice. 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The formula greatly generalizes the previously known special cases and treats also the case of non-standard Kodaira types for non-perfect residue fields.","lang":"eng"}],"year":"2025","supplementarymaterial":"no","OA_place":"publisher","acknowledgement":"Silverman, and Paul Voutier for the comments on the earlier version of this paper. The first author acknowledges the support by Dioscuri programme initiated by the Max Planck Society, jointly managed with the National Science Centre (Poland), and mutually funded by the Polish Ministry of Science and Higher Education and the German Federal Ministry of Education and Research. The second author has been supported by MIUR (Italy) through PRIN 2017 ‘Geometric, algebraic and analytic methods in arithmetic’ and has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 101034413.","citation":{"mla":"Naskręcki, Bartosz, and Matteo Verzobio. “Common Valuations of Division Polynomials.” Proceedings of the Royal Society of Edinburgh Section A: Mathematics, vol. 155, no. 5, Cambridge University Press, 2025, pp. 1646–60, doi:10.1017/prm.2024.7.","chicago":"Naskręcki, Bartosz, and Matteo Verzobio. “Common Valuations of Division Polynomials.” Proceedings of the Royal Society of Edinburgh Section A: Mathematics. Cambridge University Press, 2025. https://doi.org/10.1017/prm.2024.7.","short":"B. Naskręcki, M. Verzobio, Proceedings of the Royal Society of Edinburgh Section A: Mathematics 155 (2025) 1646–1660.","ista":"Naskręcki B, Verzobio M. 2025. Common valuations of division polynomials. Proceedings of the Royal Society of Edinburgh Section A: Mathematics. 155(5), 1646–1660.","ama":"Naskręcki B, Verzobio M. Common valuations of division polynomials. Proceedings of the Royal Society of Edinburgh Section A: Mathematics. 2025;155(5):1646-1660. doi:10.1017/prm.2024.7","ieee":"B. Naskręcki and M. Verzobio, “Common valuations of division polynomials,” Proceedings of the Royal Society of Edinburgh Section A: Mathematics, vol. 155, no. 5. Cambridge University Press, pp. 1646–1660, 2025.","apa":"Naskręcki, B., & Verzobio, M. (2025). Common valuations of division polynomials. Proceedings of the Royal Society of Edinburgh Section A: Mathematics. Cambridge University Press. https://doi.org/10.1017/prm.2024.7"},"day":"01","publication":"Proceedings of the Royal Society of Edinburgh Section A: Mathematics","quality_controlled":"1","das_tickbox":"0","_id":"12311","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"content_type":"application/pdf","creator":"dernst","date_created":"2025-12-30T06:45:47Z","access_level":"open_access","date_updated":"2025-12-30T06:45:47Z","file_size":477624,"file_name":"2025_ProceedingsRoyalSocEdinburghA_Naskrecki.pdf","file_id":"20878","success":1,"checksum":"c5ec6e29aca2fb4533cb95fac409a0b2","relation":"main_file"}],"publication_status":"published","has_accepted_license":"1"},{"das_tickbox":"1","publication":"Mathematische Annalen","quality_controlled":"1","day":"01","citation":{"ama":"Glas J, Hochfilzer L. On a question of Davenport and diagonal cubic forms over Fq(t). Mathematische Annalen. 2025;391:5485-5533. doi:10.1007/s00208-024-03035-z","ieee":"J. Glas and L. Hochfilzer, “On a question of Davenport and diagonal cubic forms over Fq(t),” Mathematische Annalen, vol. 391. Springer Nature, pp. 5485–5533, 2025.","apa":"Glas, J., & Hochfilzer, L. (2025). On a question of Davenport and diagonal cubic forms over Fq(t). Mathematische Annalen. Springer Nature. https://doi.org/10.1007/s00208-024-03035-z","chicago":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” Mathematische Annalen. Springer Nature, 2025. https://doi.org/10.1007/s00208-024-03035-z.","mla":"Glas, Jakob, and Leonhard Hochfilzer. “On a Question of Davenport and Diagonal Cubic Forms over Fq(T).” Mathematische Annalen, vol. 391, Springer Nature, 2025, pp. 5485–533, doi:10.1007/s00208-024-03035-z.","ista":"Glas J, Hochfilzer L. 2025. On a question of Davenport and diagonal cubic forms over Fq(t). Mathematische Annalen. 391, 5485–5533.","short":"J. Glas, L. Hochfilzer, Mathematische Annalen 391 (2025) 5485–5533."},"_id":"18705","file":[{"relation":"main_file","checksum":"dcf57a8b01332c36e0cf2b0d1aeecb36","success":1,"file_id":"19579","file_name":"2025_MathAnnalen_Glas.pdf","file_size":650021,"date_updated":"2025-04-16T09:38:55Z","access_level":"open_access","date_created":"2025-04-16T09:38:55Z","creator":"dernst","content_type":"application/pdf"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","publication_status":"published","corr_author":"1","status":"public","title":"On a question of Davenport and diagonal cubic forms over Fq(t)","abstract":[{"text":"Given a non-singular diagonal cubic hypersurface X⊂Pn−1 over Fq(t) with char(Fq)≠3, we show that the number of rational points of height at most |P| is O(|P|3+ε) for n=6 and O(|P|2+ε) for n=4. In fact, if n=4 and char(Fq)>3 we prove that the number of rational points away from any rational line contained in X is bounded by O(|P|3/2+ε). From the result in 6 variables we deduce weak approximation for diagonal cubic hypersurfaces for n≥7 over Fq(t) when char(Fq)>3 and handle Waring's problem for cubes in 7 variables over Fq(t) when char(Fq)≠3. Our results answer a question of Davenport regarding the number of solutions of bounded height to x31+x32+x33=x34+x35+x36 with xi∈Fq[t].","lang":"eng"}],"year":"2025","dataavailabilitystatement":"Data sharing is not applicable to this article as no datasets were generated or analysed\r\nduring the current study.","supplementarymaterial":"no","OA_place":"publisher","acknowledgement":"Open Access funding enabled and organized by Projekt DEAL.\r\nThe authors would like to thank Tim Browning for suggesting this project. Further they are grateful for his and Damaris Schindler’s helpful comments. We would also like to thank Efthymios Sofos for bringing Davenport’s question to our attention and Keith Matthews for providing us with scanned copies of the original correspondence. Finally we would like to thank the reviewer for helpful comments.","page":"5485-5533","type":"journal_article","month":"04","isi":1,"arxiv":1,"doi":"10.1007/s00208-024-03035-z","date_published":"2025-04-01T00:00:00Z","researchdata_availability":"not applicable","publication_identifier":{"eissn":["1432-1807"],"issn":["0025-5831"]},"external_id":{"arxiv":["2208.05422"],"isi":["001376740400001"]},"volume":391,"file_date_updated":"2025-04-16T09:38:55Z","ddc":["510"],"publisher":"Springer Nature","article_type":"original","oa_version":"Published Version","date_created":"2024-12-22T23:01:48Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-21T11:06:30Z","related_material":{"record":[{"id":"18293","relation":"earlier_version","status":"public"}]},"fulldoi":"https://doi.org/10.1007/s00208-024-03035-z","intvolume":" 391","language":[{"iso":"eng"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"TiBr"}],"author":[{"id":"d6423cba-dc74-11ea-a0a7-ee61689ff5fb","first_name":"Jakob","last_name":"Glas","full_name":"Glas, Jakob"},{"last_name":"Hochfilzer","full_name":"Hochfilzer, Leonhard","first_name":"Leonhard"}],"scopus_import":"1","oa":1},{"article_processing_charge":"Yes (via OA deal)","author":[{"full_name":"Bartocci, Ezio","last_name":"Bartocci","first_name":"Ezio"},{"orcid":"0000-0001-5199-3143","first_name":"Thomas","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","full_name":"Ferrere, Thomas","last_name":"Ferrere"},{"last_name":"Henzinger","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","orcid":"0000-0002-2985-7724"},{"id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87","first_name":"Dejan","last_name":"Nickovic","full_name":"Nickovic, Dejan"},{"id":"f347ec37-6676-11ee-b395-a888cb7b4fb4","first_name":"Ana","orcid":"0000-0002-8741-5799","last_name":"Oliveira da Costa","full_name":"Oliveira da Costa, Ana"}],"department":[{"_id":"ToHe"}],"OA_type":"hybrid","oa":1,"scopus_import":"1","fulldoi":"https://doi.org/10.1007/s10703-024-00447-0","project":[{"grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","call_identifier":"H2020"},{"grant_number":"F8502","_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","name":"Interface Theory for Security and Privacy"}],"intvolume":" 66","language":[{"iso":"eng"}],"date_created":"2024-06-02T22:00:57Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2026-10-21T12:02:29Z","PlanS_conform":"1","related_material":{"record":[{"status":"public","relation":"shorter_version","id":"11355"}]},"volume":66,"ddc":["000"],"file_date_updated":"2025-12-30T06:50:12Z","publisher":"Springer Nature","oa_version":"Published Version","article_type":"original","arxiv":1,"doi":"10.1007/s10703-024-00447-0","date_published":"2025-05-01T00:00:00Z","researchdata_availability":"not applicable","publication_identifier":{"eissn":["1572-8102"],"issn":["0925-9856"]},"external_id":{"arxiv":["2002.06465"],"isi":["001230084200001"]},"ec_funded":1,"page":"3-48","type":"journal_article","isi":1,"month":"05","title":"Information-flow interfaces","status":"public","corr_author":"1","dataavailabilitystatement":"This manuscript has no associated data.\r\n\r\n","abstract":[{"lang":"eng","text":"Contract-based design is a promising methodology for taming the complexity of developing sophisticated systems. A formal contract distinguishes between assumptions, which are constraints that the designer of a component puts on the environments in which the component can be used safely, and guarantees, which are promises that the designer asks from the team that implements the component. A theory of formal contracts can be formalized as an interface theory, which supports the composition and refinement of both assumptions and guarantees. Although there is a rich landscape of contract-based design methods that address functional and extra-functional properties, we present the first interface theory designed to ensure system-wide security properties. Our framework provides a refinement relation and a composition operation that support both incremental design and independent implementability. We develop our theory for both stateless and stateful interfaces. Additionally, we introduce information-flow contracts where assumptions and guarantees are sets of flow relations. We use these contracts to illustrate how to enrich information-flow interfaces with a semantic view. We illustrate the applicability of our framework with two examples inspired by the automotive domain."}],"year":"2025","supplementarymaterial":"yes","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 956123 and it was funded in part by the Austrian Science Fund (FWF) project W1255-N23, by the Austrian FWF project ZK-35, by the FWF project SpyCoDe 10.55776/F85 and by the ERC-2020-AdG 101020093. This paper extends the text and the results of the manuscript published at FASE 2022 [1].","OA_place":"publisher","day":"01","citation":{"apa":"Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., & Oliveira da Costa, A. (2025). Information-flow interfaces. Formal Methods in System Design. Springer Nature. https://doi.org/10.1007/s10703-024-00447-0","ama":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Oliveira da Costa A. Information-flow interfaces. Formal Methods in System Design. 2025;66:3-48. doi:10.1007/s10703-024-00447-0","ieee":"E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. Oliveira da Costa, “Information-flow interfaces,” Formal Methods in System Design, vol. 66. Springer Nature, pp. 3–48, 2025.","short":"E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A. Oliveira da Costa, Formal Methods in System Design 66 (2025) 3–48.","ista":"Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Oliveira da Costa A. 2025. Information-flow interfaces. Formal Methods in System Design. 66, 3–48.","mla":"Bartocci, Ezio, et al. “Information-Flow Interfaces.” Formal Methods in System Design, vol. 66, Springer Nature, 2025, pp. 3–48, doi:10.1007/s10703-024-00447-0.","chicago":"Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and Ana Oliveira da Costa. “Information-Flow Interfaces.” Formal Methods in System Design. Springer Nature, 2025. https://doi.org/10.1007/s10703-024-00447-0."},"das_tickbox":"1","publication":"Formal Methods in System Design","quality_controlled":"1","_id":"17094","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_id":"20879","success":1,"file_name":"2025_FormalMethodsSysDesign_Bartocci.pdf","checksum":"244a71a916103b8ea08e9d0bab32bcd9","relation":"main_file","date_created":"2025-12-30T06:50:12Z","access_level":"open_access","content_type":"application/pdf","creator":"dernst","date_updated":"2025-12-30T06:50:12Z","file_size":3860690}],"publication_status":"published","has_accepted_license":"1"},{"ddc":["516"],"file_date_updated":"2025-09-11T12:26:14Z","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","degree_awarded":"PhD","date_created":"2025-09-10T12:17:55Z","related_material":{"record":[{"relation":"part_of_dissertation","id":"20008","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"19860"},{"status":"public","relation":"part_of_dissertation","id":"15168"}]},"date_updated":"2026-10-21T13:23:55Z","fulldoi":"https://doi.org/10.15479/AT-ISTA-20339","language":[{"iso":"eng"}],"oa":1,"author":[{"last_name":"Tasinato","full_name":"Tasinato, Gianluca","id":"0433290C-AF8F-11E9-A4C7-F729E6697425","first_name":"Gianluca"}],"article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"UlWa"}],"supervisor":[{"orcid":"0000-0002-1494-0568","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","first_name":"Uli","last_name":"Wagner","full_name":"Wagner, Uli"}],"_id":"20339","day":"10","alternative_title":["ISTA Thesis"],"citation":{"short":"G. Tasinato, Topological Methods in Discrete Geometry and Theoretical Computer Science: Measure Partitioning and Constraint Satisfaction Problems, Institute of Science and Technology Austria, 2025.","ista":"Tasinato G. 2025. Topological methods in discrete geometry and theoretical computer science: Measure partitioning and constraint satisfaction problems. Institute of Science and Technology Austria.","mla":"Tasinato, Gianluca. Topological Methods in Discrete Geometry and Theoretical Computer Science: Measure Partitioning and Constraint Satisfaction Problems. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20339.","chicago":"Tasinato, Gianluca. “Topological Methods in Discrete Geometry and Theoretical Computer Science: Measure Partitioning and Constraint Satisfaction Problems.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20339.","apa":"Tasinato, G. (2025). Topological methods in discrete geometry and theoretical computer science: Measure partitioning and constraint satisfaction problems. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20339","ieee":"G. Tasinato, “Topological methods in discrete geometry and theoretical computer science: Measure partitioning and constraint satisfaction problems,” Institute of Science and Technology Austria, 2025.","ama":"Tasinato G. Topological methods in discrete geometry and theoretical computer science: Measure partitioning and constraint satisfaction problems. 2025. doi:10.15479/AT-ISTA-20339"},"has_accepted_license":"1","publication_status":"published","file":[{"file_id":"20344","file_name":"thesis-source.zip","checksum":"ae097a515b9bb4d4b025ca854ae2ed76","relation":"source_file","date_created":"2025-09-11T12:24:12Z","access_level":"closed","content_type":"application/x-zip-compressed","creator":"gtasinat","date_updated":"2025-09-11T12:24:12Z","file_size":2218562},{"relation":"main_file","checksum":"04b2e016409e52167ce42b0eef839fbf","file_name":"2025_Tasinato_Gianluca_Thesis.pdf","success":1,"file_id":"20345","file_size":10071982,"date_updated":"2025-09-11T12:26:14Z","content_type":"application/pdf","creator":"gtasinat","access_level":"open_access","date_created":"2025-09-11T12:26:14Z"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","abstract":[{"text":"This thesis investigates the interplay between algebraic and topological methods and combinatorial problems, focusing on approximate graph colourings and mass partitioning. The unifying theme throughout the dissertation is the use of continuous maps and symmetry constraints to extract combinatorial insights.\r\n\r\nWe first explore approximate graph colouring problems and more generally promise constraint satisfaction problems. Using tools from equivariant topology in combination with the general theory of polymorphism of a promise constraint satisfaction problem, we establish hardness for specific types of approximations.\r\n\r\nIn the second part, we address mass partitioning problems, where one seeks to divide geometric objects or measures in Euclidean space into parts of equal size using hyperplanes. Employing techniques from topological combinatorics (configuration space/test map setup and Borsuk–Ulam type theorems), we both obtain a new equipartitioning result in the and provide a fast algorithm for computing equipartitioning of point sets in 3D.\r\n","lang":"eng"}],"year":"2025","corr_author":"1","status":"public","title":"Topological methods in discrete geometry and theoretical computer science: Measure partitioning and constraint satisfaction problems","OA_place":"publisher","type":"dissertation","page":"106","month":"09","doi":"10.15479/AT-ISTA-20339","date_published":"2025-09-10T00:00:00Z","doi_confirm":"1","publication_identifier":{"issn":["2663-337X"]}},{"date_updated":"2026-10-21T13:42:19Z","date_created":"2024-09-29T22:01:38Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Springer Nature","oa_version":"Published Version","article_type":"original","volume":47,"ddc":["510"],"file_date_updated":"2025-04-08T11:17:45Z","department":[{"_id":"UlWa"},{"_id":"MaKw"}],"author":[{"last_name":"Brunck","full_name":"Brunck, Florestan R","id":"6ab6e556-f394-11eb-9cf6-9dfb78f00d8d","first_name":"Florestan R"},{"full_name":"Kwan, Matthew Alan","last_name":"Kwan","orcid":"0000-0002-4003-7567","first_name":"Matthew Alan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","oa":1,"scopus_import":"1","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1007/s00283-024-10358-x","intvolume":" 47","supplementarymaterial":"no","acknowledgement":"Open access funding provided by Copenhagen University.","OA_place":"publisher","status":"public","title":"Books, Hallways, and social butterflies: A note on sliding block puzzles","abstract":[{"lang":"eng","text":"Interest in sliding block puzzles dates back to the 15-puzzle, seemingly invented by Noyes Chapman in 1874 (see [23] for an account of the fascinating history of the puzzle). The game consists of fifteen movable square blocks numbered \r\n and arranged within a \r\n square box, leaving one empty space (see Figure 1). The task at hand is to start from a given configuration of the numbered blocks and reach the desired target configuration, where the only allowed move is to slide a numbered block into an adjacent empty space. This task seemed to be unpredictably either very easy to accomplish, or completely impossible, and the puzzle turned into a worldwide sensation in the spring of 1880. A particularly challenging instance, known as the 13-15-14 puzzle, consisted of initial and target configurations that differed by a single swap (historically this swap involved the blocks labeled 14 and 15). The craze of this puzzle was such that it consistently made newspaper headlines in 1880, with an article in the New York Times lamenting that it was “threatening our free institutions” [23, p. 9]. Various prizes were offered for anyone who could solve this challenge, beginning with a $25 set of teeth and culminating with Sam Loyd’s famous $1,000 cash prize."}],"year":"2025","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_name":"2025_MathIntelligencer_Brunck.pdf","file_id":"19530","success":1,"checksum":"c932ebe45c460d4a73f5b2dcca643db1","relation":"main_file","content_type":"application/pdf","creator":"dernst","date_created":"2025-04-08T11:17:45Z","access_level":"open_access","date_updated":"2025-04-08T11:17:45Z","file_size":1760643}],"has_accepted_license":"1","publication_status":"published","citation":{"chicago":"Brunck, Florestan R, and Matthew Alan Kwan. “Books, Hallways, and Social Butterflies: A Note on Sliding Block Puzzles.” Mathematical Intelligencer. Springer Nature, 2025. https://doi.org/10.1007/s00283-024-10358-x.","mla":"Brunck, Florestan R., and Matthew Alan Kwan. “Books, Hallways, and Social Butterflies: A Note on Sliding Block Puzzles.” Mathematical Intelligencer, vol. 47, Springer Nature, 2025, pp. 52–65, doi:10.1007/s00283-024-10358-x.","ista":"Brunck FR, Kwan MA. 2025. Books, Hallways, and social butterflies: A note on sliding block puzzles. Mathematical Intelligencer. 47, 52–65.","short":"F.R. Brunck, M.A. Kwan, Mathematical Intelligencer 47 (2025) 52–65.","ama":"Brunck FR, Kwan MA. Books, Hallways, and social butterflies: A note on sliding block puzzles. Mathematical Intelligencer. 2025;47:52-65. doi:10.1007/s00283-024-10358-x","ieee":"F. R. Brunck and M. A. Kwan, “Books, Hallways, and social butterflies: A note on sliding block puzzles,” Mathematical Intelligencer, vol. 47. Springer Nature, pp. 52–65, 2025.","apa":"Brunck, F. R., & Kwan, M. A. (2025). Books, Hallways, and social butterflies: A note on sliding block puzzles. Mathematical Intelligencer. Springer Nature. https://doi.org/10.1007/s00283-024-10358-x"},"day":"01","publication":"Mathematical Intelligencer","das_tickbox":"0","quality_controlled":"1","_id":"18157","researchdata_availability":"no","publication_identifier":{"issn":["0343-6993"]},"external_id":{"arxiv":["2303.09459"],"isi":["001318056000001"]},"arxiv":1,"doi":"10.1007/s00283-024-10358-x","date_published":"2025-03-01T00:00:00Z","isi":1,"month":"03","page":"52-65","type":"journal_article"},{"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1145/3748723","issue":"4","intvolume":" 21","department":[{"_id":"VlKo"}],"author":[{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","scopus_import":"1","oa":1,"publisher":"Association for Computing Machinery","article_type":"original","oa_version":"Published Version","volume":21,"ddc":["510"],"file_date_updated":"2026-01-21T09:38:09Z","date_updated":"2026-10-21T13:45:27Z","PlanS_conform":"1","related_material":{"record":[{"status":"public","relation":"shorter_version","id":"17236"}]},"date_created":"2026-01-20T10:04:02Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"10","page":"1-22","type":"journal_article","publication_identifier":{"eissn":["1549-6333"],"issn":["1549-6325"]},"external_id":{"arxiv":["2307.00115"]},"arxiv":1,"date_published":"2025-10-01T00:00:00Z","doi":"10.1145/3748723","file":[{"file_size":2208302,"date_updated":"2026-01-21T09:38:09Z","content_type":"application/pdf","creator":"dernst","access_level":"open_access","date_created":"2026-01-21T09:38:09Z","relation":"main_file","checksum":"4a80fdb1e3711b9a2768d2bb8f6d3b4e","file_name":"2025_ACMToA_Kolmogorov.pdf","success":1,"file_id":"21031"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_status":"published","has_accepted_license":"1","quality_controlled":"1","publication":"ACM Transactions on Algorithms","citation":{"ieee":"V. Kolmogorov, “A simpler and parallelizable O(√log n)-approximation algorithm for SPARSEST CUT,” ACM Transactions on Algorithms, vol. 21, no. 4. Association for Computing Machinery, pp. 1–22, 2025.","ama":"Kolmogorov V. A simpler and parallelizable O(√log n)-approximation algorithm for SPARSEST CUT. ACM Transactions on Algorithms. 2025;21(4):1-22. doi:10.1145/3748723","apa":"Kolmogorov, V. (2025). A simpler and parallelizable O(√log n)-approximation algorithm for SPARSEST CUT. ACM Transactions on Algorithms. Association for Computing Machinery. https://doi.org/10.1145/3748723","mla":"Kolmogorov, Vladimir. “A Simpler and Parallelizable O(√log n)-Approximation Algorithm for SPARSEST CUT.” ACM Transactions on Algorithms, vol. 21, no. 4, Association for Computing Machinery, 2025, pp. 1–22, doi:10.1145/3748723.","chicago":"Kolmogorov, Vladimir. “A Simpler and Parallelizable O(√log n)-Approximation Algorithm for SPARSEST CUT.” ACM Transactions on Algorithms. Association for Computing Machinery, 2025. https://doi.org/10.1145/3748723.","ista":"Kolmogorov V. 2025. A simpler and parallelizable O(√log n)-approximation algorithm for SPARSEST CUT. ACM Transactions on Algorithms. 21(4), 1–22.","short":"V. Kolmogorov, ACM Transactions on Algorithms 21 (2025) 1–22."},"day":"01","_id":"21007","OA_place":"publisher","corr_author":"1","title":"A simpler and parallelizable O(√log n)-approximation algorithm for SPARSEST CUT","status":"public","abstract":[{"text":"Currently, the best known tradeoff between approximation ratio and complexity for the Sparsest Cut problem is achieved by the algorithm in [Sherman, FOCS 2009]: it computes O(√(log n)/ε)-approximation using O(nε logO(1) n) maxflows for any ε∈[Θ(1/log n),Θ(1)]. It works by solving the SDP relaxation of [Arora-Rao-Vazirani, STOC 2004] using the Multiplicative Weights Update algorithm (MW) of [Arora-Kale, JACM 2016]. To implement one MW step, Sherman approximately solves a multicommodity flow problem using another application of MW. Nested MW steps are solved via a certain \"chaining\" algorithm that combines results of multiple calls to the maxflow algorithm. We present an alternative approach that avoids solving the multicommodity flow problem and instead computes \"violating paths\". This simplifies Sherman's algorithm by removing a need for a nested application of MW, and also allows parallelization: we show how to compute O(√(log n)/ε)-approximation via O(logO(1) n) maxflows using O(nε) processors. We also revisit Sherman's chaining algorithm, and present a simpler version together with a new analysis.","lang":"eng"}],"year":"2025"},{"publication_identifier":{"eissn":["1530-6992"],"issn":["1530-6984"]},"external_id":{"arxiv":["2407.15314"],"isi":["001415246000001"]},"arxiv":1,"date_published":"2025-02-06T00:00:00Z","doi":"10.1021/acs.nanolett.4c05796","isi":1,"month":"02","page":"2749-2755","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2407.15314","open_access":"1"}],"type":"journal_article","acknowledgement":"We thank Carissa Kumar and Vibha Padmanabhan for assistance in comparing performance with devices across the literature. We thank Andrew Cleland for helpful comments on this work. We are grateful for support from the Miba Machine Shop and Nanofabrication facility at IST Austria. This work was supported by the Austrian FWF grant P33692–N and includes a recipient of a DOC Fellowship of the Austrian Academy of Sciences (DOC – No. 26088) at the Institute of Science and Technology, Austria.","OA_place":"repository","status":"public","title":"Room temperature, cavity-free capacitive strong coupling to mechanical motion","corr_author":"1","abstract":[{"text":"The back-action damping of mechanical motion by electromagnetic radiation is typically overwhelmed by internal loss channels unless demanding experimental ingredients such as superconducting resonators, high-quality optical cavities, or large magnetic fields are employed. Here we demonstrate the first room temperature, cavity-free, all-electric device where back-action damping exceeds internal loss, enabled by a mechanically compliant parallel-plate capacitor with a nanoscale plate separation and an aspect ratio exceeding 1,000. The device has 4 orders of magnitude lower insertion loss than a comparable commercial quartz crystal and achieves a position imprecision rivaling optical interferometers. With the help of a back-action isolation scheme, we observe radiative cooling of mechanical motion by a remote cryogenic load. This work provides a technologically accessible route to high-precision sensing, transduction, and signal processing.","lang":"eng"}],"year":"2025","publication_status":"published","day":"06","citation":{"chicago":"Puglia, Denise, Rachel H Odessey, Peter Burns, Niklas Luhmann, Silvan Schmid, and Andrew P Higginbotham. “Room Temperature, Cavity-Free Capacitive Strong Coupling to Mechanical Motion.” Nano Letters. American Chemical Society, 2025. https://doi.org/10.1021/acs.nanolett.4c05796.","mla":"Puglia, Denise, et al. “Room Temperature, Cavity-Free Capacitive Strong Coupling to Mechanical Motion.” Nano Letters, vol. 25, no. 7, American Chemical Society, 2025, pp. 2749–55, doi:10.1021/acs.nanolett.4c05796.","short":"D. Puglia, R.H. Odessey, P. Burns, N. Luhmann, S. Schmid, A.P. Higginbotham, Nano Letters 25 (2025) 2749–2755.","ista":"Puglia D, Odessey RH, Burns P, Luhmann N, Schmid S, Higginbotham AP. 2025. Room temperature, cavity-free capacitive strong coupling to mechanical motion. Nano Letters. 25(7), 2749–2755.","ama":"Puglia D, Odessey RH, Burns P, Luhmann N, Schmid S, Higginbotham AP. Room temperature, cavity-free capacitive strong coupling to mechanical motion. Nano Letters. 2025;25(7):2749-2755. doi:10.1021/acs.nanolett.4c05796","ieee":"D. Puglia, R. H. Odessey, P. Burns, N. Luhmann, S. Schmid, and A. P. Higginbotham, “Room temperature, cavity-free capacitive strong coupling to mechanical motion,” Nano Letters, vol. 25, no. 7. American Chemical Society, pp. 2749–2755, 2025.","apa":"Puglia, D., Odessey, R. H., Burns, P., Luhmann, N., Schmid, S., & Higginbotham, A. P. (2025). Room temperature, cavity-free capacitive strong coupling to mechanical motion. Nano Letters. American Chemical Society. https://doi.org/10.1021/acs.nanolett.4c05796"},"quality_controlled":"1","publication":"Nano Letters","_id":"19026","article_processing_charge":"No","author":[{"last_name":"Puglia","full_name":"Puglia, Denise","id":"4D495994-AE37-11E9-AC72-31CAE5697425","first_name":"Denise","orcid":"0000-0003-1144-2763"},{"id":"9a7a5123-8972-11ed-ae7b-dd1f2af457bd","first_name":"Rachel H","last_name":"Odessey","full_name":"Odessey, Rachel H"},{"full_name":"Burns, Peter","last_name":"Burns","first_name":"Peter"},{"full_name":"Luhmann, Niklas","last_name":"Luhmann","first_name":"Niklas"},{"last_name":"Schmid","full_name":"Schmid, Silvan","first_name":"Silvan"},{"last_name":"Higginbotham","full_name":"Higginbotham, Andrew P","orcid":"0000-0003-2607-2363","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","first_name":"Andrew P"}],"OA_type":"green","department":[{"_id":"AnHi"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"scopus_import":"1","oa":1,"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1021/acs.nanolett.4c05796","project":[{"grant_number":"P33692","_id":"0aa3608a-070f-11eb-9043-e9cd8a2bd931","name":"Cavity electromechanics across a quantum phase transition"},{"grant_number":"26088","_id":"62843413-2b32-11ec-9570-c4ec6eabfae7","name":"Surface Charge and Tunneling Multi-Mode Imaging"}],"issue":"7","intvolume":" 25","date_updated":"2026-10-21T14:08:09Z","related_material":{"record":[{"id":"18143","relation":"earlier_version","status":"public"}]},"date_created":"2025-02-16T23:02:34Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"American Chemical Society","oa_version":"Preprint","article_type":"original","volume":25},{"oa":1,"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"JiFr"},{"_id":"XiFe"}],"OA_type":"hybrid","author":[{"orcid":"0000-0002-7244-7237","id":"3922B506-F248-11E8-B48F-1D18A9856A87","first_name":"Lesia","last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","first_name":"Lukas","last_name":"Fiedler","full_name":"Fiedler, Lukas"},{"last_name":"Zou","full_name":"Zou, Minxia","id":"5c243f41-03f3-11ec-841c-96faf48a7ef9","first_name":"Minxia"},{"full_name":"Giannini, Caterina","last_name":"Giannini","first_name":"Caterina","id":"e3fdddd5-f6e0-11ea-865d-ca99ee6367f4"},{"last_name":"Monzer","full_name":"Monzer, Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","first_name":"Aline"},{"id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","first_name":"Dmitrii","last_name":"Vladimirtsev","full_name":"Vladimirtsev, Dmitrii"},{"first_name":"Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","full_name":"Randuch, Marek","last_name":"Randuch"},{"full_name":"Yu, Yongfan","last_name":"Yu","first_name":"Yongfan"},{"full_name":"Gelová, Zuzana","last_name":"Gelová","first_name":"Zuzana","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","orcid":"0000-0003-4783-1752"},{"last_name":"Verstraeten","full_name":"Verstraeten, Inge","orcid":"0000-0001-7241-2328","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","first_name":"Inge"},{"orcid":"0000-0003-2140-7195","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","first_name":"Jakub","last_name":"Hajny","full_name":"Hajny, Jakub"},{"first_name":"Meng","last_name":"Chen","full_name":"Chen, Meng"},{"last_name":"Tan","full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang","orcid":"0000-0002-0471-8285"},{"full_name":"Hörmayer, Lukas","last_name":"Hörmayer","orcid":"0000-0001-8295-2926","first_name":"Lukas","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Li, Lanxin","last_name":"Li","first_name":"Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X"},{"first_name":"Maria Mar","last_name":"Marques-Bueno","full_name":"Marques-Bueno, Maria Mar"},{"first_name":"Zainab","id":"32ff3c64-04a0-11f0-a50f-d0c45bfac466","full_name":"Quddoos, Zainab","last_name":"Quddoos"},{"full_name":"Molnar, Gergely","last_name":"Molnar","first_name":"Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87"},{"id":"57a1567c-8314-11eb-9063-c9ddc3451a54","first_name":"Ivan","last_name":"Kulich","full_name":"Kulich, Ivan"},{"last_name":"Jaillais","full_name":"Jaillais, Yvon","first_name":"Yvon"},{"last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"intvolume":" 188","issue":"22","project":[{"grant_number":"101142681","name":"Cyclic nucleotides as second messengers in plants","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"grant_number":"I06123","name":"Peptide receptors for auxin canalization in Arabidopsis","_id":"bd76d395-d553-11ed-ba76-f678c14f9033"},{"name":"Cell surface receptor complexes for auxin signaling in plants","_id":"26060676-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 985-2016"},{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"}],"fulldoi":"https://doi.org/10.1016/j.cell.2025.08.026","related_material":{"record":[{"status":"public","id":"19399","relation":"earlier_version"},{"relation":"dissertation_contains","id":"23145","status":"public"}]},"PlanS_conform":"1","date_updated":"2026-10-22T09:15:44Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-11-19T09:44:31Z","oa_version":"Published Version","article_type":"original","publisher":"Cell Press","pmid":1,"file_date_updated":"2025-11-24T10:55:18Z","ddc":["580"],"volume":188,"external_id":{"isi":["001616077900005"],"pmid":["41043433"]},"publication_identifier":{"issn":["0092-8674"]},"date_published":"2025-10-30T00:00:00Z","doi":"10.1016/j.cell.2025.08.026","isi":1,"month":"10","type":"journal_article","ec_funded":1,"page":"6138-6150.e17","acknowledgement":"We gratefully acknowledge Tongda Xu for experimental, material, and conceptual support. We thank William Gray for providing material, Nataliia Gnyliukh and Ema Cervenova for help with manuscript preparation, and Julia Schmid for help with cloning. We thank Dolf Weijers, Mark Roosjen, and Andre Kuhn for discussions and support with phospho-proteomic analyses. We thank the Bioimaging and Life Science facilities at the Institute of Science and Technology Austria (ISTA) for their excellent service and assistance. The research leading to these results has received funding from the European Union (ERC, CYNIPS, 101142681) and Austrian Science Fund (FWF; I 6123-B) to J.F., and Y.J. was funded by ERC no. 3363360-APPL under FP/2007-2013. L.R. was supported by the FP7-PEOPLE-2011-COFUND ISTFELLOW program (IC1023FELL01) and the European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 985-2016). S.T. was supported by the National Natural Science Foundation of China (32321001, 32570366). The work of J.H. was supported by the project JG_2024_003 implemented within the Palacký University Young Researcher Grant.","OA_place":"publisher","year":"2025","abstract":[{"text":"Phytohormone auxin and its directional transport mediate much of the remarkably plastic development of higher plants. Positive feedback between auxin signaling and transport is a prerequisite for (1) self-organizing processes, including vascular tissue formation, and (2) directional growth responses such as gravitropism. Here, we identify a mechanism by which auxin signaling directly targets PIN auxin transporters. Via the cell-surface AUXIN-BINDING PROTEIN1 (ABP1)-TRANSMEMBRANE KINASE 1 (TMK1) receptor module, auxin rapidly induces phosphorylation and thus stabilization of PIN2. Following gravistimulation, initial auxin asymmetry activates autophosphorylation of the TMK1 kinase. This induces TMK1 interaction with and phosphorylation of PIN2, stabilizing PIN2 at the lower root side, thus reinforcing asymmetric auxin flow for root bending. Upstream of TMK1 in this regulation, ABP1 acts redundantly with the root-expressed ABP1-LIKE 3 (ABL3) auxin receptor. Such positive feedback between cell-surface auxin signaling and PIN-mediated polar auxin transport is fundamental for robust root gravitropism and presumably for other self-organizing developmental phenomena.","lang":"eng"}],"status":"public","title":"ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism","corr_author":"1","has_accepted_license":"1","publication_status":"published","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"creator":"dernst","content_type":"application/pdf","access_level":"open_access","date_created":"2025-11-24T10:55:18Z","file_size":17825465,"date_updated":"2025-11-24T10:55:18Z","file_name":"2025_Cell_Rodriguez.pdf","success":1,"file_id":"20679","relation":"main_file","checksum":"8ac396a0806ad7f2e4e7a0c1eed712ce"}],"_id":"20656","citation":{"mla":"Rodriguez Solovey, Lesia, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell, vol. 188, no. 22, Cell Press, 2025, p. 6138–6150.e17, doi:10.1016/j.cell.2025.08.026.","chicago":"Rodriguez Solovey, Lesia, Lukas Fiedler, Minxia Zou, Caterina Giannini, Aline Monzer, Dmitrii Vladimirtsev, Marek Randuch, et al. “ABP1/ABL3-TMK1 Cell-Surface Auxin Signaling Targets PIN2-Mediated Auxin Fluxes for Root Gravitropism.” Cell. Cell Press, 2025. https://doi.org/10.1016/j.cell.2025.08.026.","short":"L. Rodriguez Solovey, L. Fiedler, M. Zou, C. Giannini, A. Monzer, D. Vladimirtsev, M. Randuch, Y. Yu, Z. Gelová, I. Verstraeten, J. Hajny, M. Chen, S. Tan, L. Hörmayer, L. Li, M.M. Marques-Bueno, Z. Quddoos, G. Molnar, I. Kulich, Y. Jaillais, J. Friml, Cell 188 (2025) 6138–6150.e17.","ista":"Rodriguez Solovey L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajny J, Chen M, Tan S, Hörmayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnar G, Kulich I, Jaillais Y, Friml J. 2025. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 188(22), 6138–6150.e17.","ieee":"L. Rodriguez Solovey et al., “ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism,” Cell, vol. 188, no. 22. Cell Press, p. 6138–6150.e17, 2025.","ama":"Rodriguez Solovey L, Fiedler L, Zou M, et al. ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. 2025;188(22):6138-6150.e17. doi:10.1016/j.cell.2025.08.026","apa":"Rodriguez Solovey, L., Fiedler, L., Zou, M., Giannini, C., Monzer, A., Vladimirtsev, D., … Friml, J. (2025). ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism. Cell. Cell Press. https://doi.org/10.1016/j.cell.2025.08.026"},"day":"30","quality_controlled":"1","publication":"Cell"},{"oa":1,"department":[{"_id":"JiFr"}],"author":[{"id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","first_name":"Marek","last_name":"Randuch","full_name":"Randuch, Marek"},{"full_name":"Kulich, Ivan","last_name":"Kulich","first_name":"Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54"},{"full_name":"Vladimirtsev, Dmitrii","last_name":"Vladimirtsev","first_name":"Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d"},{"full_name":"Huang, Shouguang","last_name":"Huang","first_name":"Shouguang"},{"first_name":"Rainer","last_name":"Hedrich","full_name":"Hedrich, Rainer"},{"last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596"}],"OA_type":"green","article_processing_charge":"No","language":[{"iso":"eng"}],"project":[{"_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681"},{"grant_number":"P37051","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6"}],"fulldoi":"https://doi.org/10.1101/2025.10.17.683082","related_material":{"record":[{"id":"23145","relation":"dissertation_contains","status":"public"}]},"date_updated":"2026-10-22T09:15:44Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2026-10-19T11:44:48Z","oa_version":"Preprint","external_id":{"biorxivid":["10.1101/2025.10.17.683082"]},"doi":"10.1101/2025.10.17.683082","date_published":"2025-10-17T00:00:00Z","month":"10","type":"preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2025.10.17.683082"}],"acknowledgement":"We gratefully acknowledge Dr. Andrea Bleckmann, creator of pBLAX000 vector and Dr. Shiqiang Gao for donation of template used in XXM-ER cloning. This research was supported by the Laboratory Support Facility, the Plant Facility, the IT Facility and the Imaging and Optical Facility of the Institute of Science and Technology Austria. The graphical elements used in Fig. 5 were adapted and modified from Servier, https://smart.servier.com, and are used under CC BY 3.0 licence. The authors acknowledge the use of AI-tools (Microsoft Copilot, Gemini) for language refinement. All content was critically reviewed by authors.\r\n\r\nFunder Information Declared\r\nEuropean Research Council, 101142681 CYNIPS\r\nAustrian Science Fund, P 37051-B","OA_place":"repository","year":"2025","abstract":[{"text":"Roots must continuously adapt their growth and have evolved the ability to rapidly respond to diverse environmental and hormonal cues, including the phytohormone auxin. Auxin-induced cellular responses involve membrane depolarization, cytosolic calcium (Ca²⁺) elevation, and extracellular pH increase, but how these processes lead to rapid growth regulation remains unclear. Here, we show that cytosolic Ca²⁺ acts as a universal signal integrating diverse cues for rapid regulation of root growth. Using live imaging, microfluidics, and optogenetics in Arabidopsis, we demonstrate that a swift rise in cytosolic Ca²⁺ is the primary target of auxin signaling affecting growth inhibition. Disruption of Ca²⁺ influx abolishes these responses, whereas light-gated Ca²⁺ influx from the apoplast or endoplasmic reticulum stores inhibits growth. Multiple unrelated stimuli—including auxin, extracellular ATP, RALF peptides, and hydrogen peroxide—converge on this Ca²⁺-dependent mechanism. Cytosolic Ca²⁺ elevation thus represents a necessary and sufficient step for rapid growth inhibition, revealing a unifying principle of root signaling.","lang":"eng"}],"corr_author":"1","biorxivid":1,"status":"public","title":"Cytosolic Ca2+ as a universal signal for rapid root growth regulation","publication_status":"draft","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"_id":"23174","publication":"bioRxiv","citation":{"apa":"Randuch, M., Kulich, I., Vladimirtsev, D., Huang, S., Hedrich, R., & Friml, J. (n.d.). Cytosolic Ca2+ as a universal signal for rapid root growth regulation. bioRxiv. https://doi.org/10.1101/2025.10.17.683082","ama":"Randuch M, Kulich I, Vladimirtsev D, Huang S, Hedrich R, Friml J. Cytosolic Ca2+ as a universal signal for rapid root growth regulation. bioRxiv. doi:10.1101/2025.10.17.683082","ieee":"M. Randuch, I. Kulich, D. Vladimirtsev, S. Huang, R. Hedrich, and J. Friml, “Cytosolic Ca2+ as a universal signal for rapid root growth regulation,” bioRxiv. .","ista":"Randuch M, Kulich I, Vladimirtsev D, Huang S, Hedrich R, Friml J. Cytosolic Ca2+ as a universal signal for rapid root growth regulation. bioRxiv, 10.1101/2025.10.17.683082.","short":"M. Randuch, I. Kulich, D. Vladimirtsev, S. Huang, R. Hedrich, J. Friml, BioRxiv (n.d.).","chicago":"Randuch, Marek, Ivan Kulich, Dmitrii Vladimirtsev, Shouguang Huang, Rainer Hedrich, and Jiří Friml. “Cytosolic Ca2+ as a Universal Signal for Rapid Root Growth Regulation.” BioRxiv, n.d. https://doi.org/10.1101/2025.10.17.683082.","mla":"Randuch, Marek, et al. “Cytosolic Ca2+ as a Universal Signal for Rapid Root Growth Regulation.” BioRxiv, doi:10.1101/2025.10.17.683082."},"day":"17"},{"day":"23","citation":{"ama":"Misova M. Dissecting gap junction biology using the C. elegans nervous system. 2025. doi:10.15479/AT-ISTA-20485","ieee":"M. Misova, “Dissecting gap junction biology using the C. elegans nervous system,” Institute of Science and Technology Austria, 2025.","apa":"Misova, M. (2025). Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20485","chicago":"Misova, Michaela. “Dissecting Gap Junction Biology Using the C. Elegans Nervous System.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20485.","mla":"Misova, Michaela. Dissecting Gap Junction Biology Using the C. Elegans Nervous System. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20485.","short":"M. Misova, Dissecting Gap Junction Biology Using the C. Elegans Nervous System, Institute of Science and Technology Austria, 2025.","ista":"Misova M. 2025. Dissecting gap junction biology using the C. elegans nervous system. Institute of Science and Technology Austria."},"alternative_title":["ISTA Thesis"],"_id":"20485","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"relation":"source_file","checksum":"e042ea314e7e13fce76c6c95e126779a","file_id":"20518","embargo_to":"open_access","file_name":"2025-Misova-Michaela-Thesis.docx","file_size":75070995,"date_updated":"2026-10-23T22:30:02Z","access_level":"closed","date_created":"2025-10-23T08:22:35Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"mmisova"},{"file_id":"20519","file_name":"2025-Misova-Michaela-Thesis.pdf","checksum":"fcd8973d6a025256eb0eb1a82c02172c","relation":"main_file","date_created":"2025-10-23T08:21:21Z","access_level":"open_access","content_type":"application/pdf","creator":"mmisova","date_updated":"2026-10-23T22:30:02Z","file_size":10974630,"embargo":"2026-10-23"}],"has_accepted_license":"1","publication_status":"published","title":"Dissecting gap junction biology using the C. elegans nervous system","status":"public","corr_author":"1","year":"2025","acknowledgement":"I would also like to acknowledge the funding that I received from the European Union’s\r\nHorizon 2020 research and Innovation programme under the Marie Sklodowska-Curie\r\nGrant Agreement No. 665385. This work would not have been possible without the contribution and support of people\r\nbehind the scientific service units at ISTA: the Life Science Facility (LSF), Imaging and\r\nOptics Facility (IOF), the Bioinformatics Unit, Protein Services Unit and\r\nElectrophysiology Unit. I would also like to recognize the work of people at the Vienna\r\nBiocenter (VBC) Mass Spectrometry Facility, particularly Markus Hartl and WeiQiang\r\nChen. ","OA_place":"publisher","ec_funded":1,"page":"155","type":"dissertation","month":"10","doi":"10.15479/AT-ISTA-20485","date_published":"2025-10-23T00:00:00Z","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-068-8"]},"file_date_updated":"2026-10-23T22:30:02Z","ddc":["570"],"publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","date_created":"2025-10-17T16:15:09Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-10-23T22:30:03Z","fulldoi":"https://doi.org/10.15479/AT-ISTA-20485","project":[{"grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"language":[{"iso":"eng"}],"author":[{"id":"495A3C32-F248-11E8-B48F-1D18A9856A87","first_name":"Michaela","orcid":"0000-0003-2427-6856","last_name":"Misova","full_name":"Misova, Michaela"}],"article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"MaDe"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"oa":1,"supervisor":[{"last_name":"de Bono","full_name":"de Bono, Mario","orcid":"0000-0001-8347-0443","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","first_name":"Mario"}]},{"doi":"10.15479/AT-ISTA-19557","date_published":"2025-04-14T00:00:00Z","publication_identifier":{"issn":["2663-337X"]},"page":"124","type":"dissertation","month":"04","status":"public","title":"Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution","corr_author":"1","year":"2025","OA_place":"publisher","acknowledgement":"The work presented in this doctoral thesis was performed at the Institute of Science\r\nand Technology (ISTA) and financially supported by a European Research Council\r\n(ERC) Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the\r\nAustrian Science Fund (FWF) to Gaia Novarino (PE1028W1232). I am very thankful\r\nto the Doctoral Program “Molecular Drug Targets” (MolTag) for offering me financial\r\nsupport to perform essential experiments during my PhD studies and to participate in\r\ninternational conferences and courses.","day":"14","citation":{"short":"L.A. Schwarz, Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution, Institute of Science and Technology Austria, 2025.","ista":"Schwarz LA. 2025. Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution. Institute of Science and Technology Austria.","chicago":"Schwarz, Lena A. “Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19557.","mla":"Schwarz, Lena A. Mapping Developmental Dynamics of Autism Spectrum Disorder Mouse Models at Single-Cell Resolution. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19557.","apa":"Schwarz, L. A. (2025). Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19557","ieee":"L. A. Schwarz, “Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution,” Institute of Science and Technology Austria, 2025.","ama":"Schwarz LA. Mapping developmental dynamics of autism spectrum disorder mouse models at single-cell resolution. 2025. doi:10.15479/AT-ISTA-19557"},"alternative_title":["ISTA Thesis"],"_id":"19557","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_updated":"2026-10-15T22:30:02Z","file_size":21783427,"creator":"lschwarz","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2025-04-15T08:43:36Z","access_level":"closed","checksum":"50290a8604edb0a720387f01e9d59fe4","relation":"source_file","file_name":"Schwarz_Thesis_2025_FINAL.docx","embargo_to":"open_access","file_id":"19561"},{"date_updated":"2026-10-15T22:30:02Z","file_size":11432175,"embargo":"2026-10-15","date_created":"2025-04-15T08:43:42Z","access_level":"open_access","content_type":"application/pdf","creator":"lschwarz","checksum":"ed028488180ac4901e018ef1c330cf01","relation":"main_file","file_id":"19562","file_name":"Schwarz_Thesis_2025_FINALpdfa.pdf"}],"has_accepted_license":"1","publication_status":"published","article_processing_charge":"No","author":[{"first_name":"Lena A","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","full_name":"Schwarz, Lena A","last_name":"Schwarz"}],"department":[{"_id":"GradSch"},{"_id":"GaNo"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"ScienComp"}],"oa":1,"supervisor":[{"last_name":"Novarino","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia"}],"project":[{"name":"Critical windows and reversibility of ASD associated with mutations in chromatin remodelers","_id":"9B91375C-BA93-11EA-9121-9846C619BF3A","grant_number":"707964"},{"name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6","grant_number":"101044865"},{"name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"W1232"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-19557","language":[{"iso":"eng"}],"date_created":"2025-04-14T06:59:06Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-10-15T22:30:03Z","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"12802"},{"status":"public","relation":"part_of_dissertation","id":"9429"}]},"file_date_updated":"2026-10-15T22:30:02Z","ddc":["570"],"publisher":"Institute of Science and Technology Austria","oa_version":"Published Version"},{"fulldoi":"https://doi.org/10.15479/AT-ISTA-20798","language":[{"iso":"eng"}],"oa":1,"department":[{"_id":"GradSch"},{"_id":"OnHo"}],"article_processing_charge":"No","author":[{"last_name":"Wald","full_name":"Wald, Sebastian","orcid":"0000-0002-5869-1604","id":"133F200A-B015-11E9-AD41-0EDAE5697425","first_name":"Sebastian"}],"supervisor":[{"id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","first_name":"Onur","orcid":"0000-0002-2031-204X","last_name":"Hosten","full_name":"Hosten, Onur"}],"file_date_updated":"2026-06-15T22:30:03Z","ddc":["530"],"oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","degree_awarded":"PhD","date_created":"2025-12-11T11:48:11Z","related_material":{"record":[{"id":"14759","relation":"part_of_dissertation","status":"public"}]},"date_updated":"2026-07-24T08:07:28Z","type":"dissertation","page":"152","month":"12","date_published":"2025-12-11T00:00:00Z","doi":"10.15479/AT-ISTA-20798","doi_confirm":"1","keyword":["entanglement-enhanced atom interferometry","cavity QED","spin-squeezing","dipole trap","quantum optics"],"publication_identifier":{"isbn":["978-3-99078-075-6"],"issn":["2663-337X"]},"_id":"20798","citation":{"mla":"Wald, Sebastian. Atoms in a Propagating-Wave Cavity for Squeezed Mach-Zehnder Atom Interferometry. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20798.","chicago":"Wald, Sebastian. “Atoms in a Propagating-Wave Cavity for Squeezed Mach-Zehnder Atom Interferometry.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20798.","ista":"Wald S. 2025. Atoms in a propagating-wave cavity for squeezed Mach-Zehnder atom interferometry. Institute of Science and Technology Austria.","short":"S. Wald, Atoms in a Propagating-Wave Cavity for Squeezed Mach-Zehnder Atom Interferometry, Institute of Science and Technology Austria, 2025.","ieee":"S. Wald, “Atoms in a propagating-wave cavity for squeezed Mach-Zehnder atom interferometry,” Institute of Science and Technology Austria, 2025.","ama":"Wald S. Atoms in a propagating-wave cavity for squeezed Mach-Zehnder atom interferometry. 2025. doi:10.15479/AT-ISTA-20798","apa":"Wald, S. (2025). Atoms in a propagating-wave cavity for squeezed Mach-Zehnder atom interferometry. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20798"},"day":"11","alternative_title":["ISTA Thesis"],"das_tickbox":"1","has_accepted_license":"1","publication_status":"published","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"file":[{"relation":"main_file","checksum":"1be72faf529a5e8a2d03cb3d5f808b77","file_id":"20809","file_name":"2025_Wald_Sebastian_Thesis.pdf","file_size":47536855,"date_updated":"2026-06-15T22:30:03Z","embargo":"2026-06-15","access_level":"open_access","date_created":"2025-12-12T11:53:42Z","content_type":"application/pdf","creator":"swald"},{"file_name":"2025_Wald_Sebastian_Thesis.zip","embargo_to":"open_access","file_id":"20810","checksum":"8c3a1904dceb4bcd04bc9f14b2594bab","relation":"source_file","creator":"swald","content_type":"application/x-zip-compressed","date_created":"2025-12-12T11:54:55Z","access_level":"closed","date_updated":"2026-06-15T22:30:03Z","file_size":40127601}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","year":"2025","abstract":[{"lang":"eng","text":"Atom interferometers measure the relative phase shifts between coherent matter-wave paths\r\nthat arise from interactions with external fields or inertial forces. Due to their exceptional\r\nphase sensitivity, atom interferometers became an essential tool for precision measurements\r\nand fundamental physics experiments, finding applications in geodesy, gravimetry, and inertial\r\nnavigation. However, their measurement precision is limited by quantum projection noise,\r\nwhich arises from the Heisenberg uncertainty principle, preventing the measurement of atomic\r\nstates with absolute precision. The generation of entanglement between the atoms offers a\r\npath to surpass this so-called standard quantum limit, thereby enhancing the interferometer’s\r\nphase sensitivity beyond classical measurement bounds.\r\nThis thesis reports on the development of an atom interferometer experiment designed to\r\nrealize cavity-mediated, squeezed Mach-Zehnder-type interferometry with ultra-cold 87Rb atoms.\r\nThe experiment combines cavity-aided spin-squeezing with cavity-mediated Mach-Zehnder\r\ninterferometry to demonstrate entanglement-enhanced phase sensitivity. The experiment is\r\ncentered on a triangular optical cavity that mediates all relevant atom-light interactions. The\r\ncavity provides optical trapping, spin-squeezing, and Raman beam-splitter operations, enabling\r\nto perform interferometry on a continuously trapped atomic ensemble.\r\nThe thesis elaborates on the fundamental theoretical framework, the cavity design, and the full\r\noptical setup, including the detailed configuration of the developed laser stabilization methods.\r\nExperimentally, continuous loading methods were explored, resulting in an accumulation of\r\nup to 4 × 106\r\natoms in the dipole trap within a cycle time of 500 ms. The AC Stark shift\r\ncompensation method developed for continuous loading was further applied for in-trap cooling\r\nto 10 µK, and optical pumping for efficient atomic state preparation. Coherent state control\r\nwas verified via observation of microwave-driven Rabi oscillations, and used to characterize\r\natom-cavity coupling.\r\nThese presented results establish the experimental groundwork for the future development of\r\ncavity-mediated, entanglement-enhanced Mach-Zehnder-type atom interferometry."}],"title":"Atoms in a propagating-wave cavity for squeezed Mach-Zehnder atom interferometry","status":"public","corr_author":"1","OA_embargo":"6","OA_place":"publisher"},{"ddc":["570"],"file_date_updated":"2025-09-27T22:30:02Z","volume":45,"article_type":"original","oa_version":"Published Version","publisher":"Society for Neuroscience","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2025-04-06T22:01:32Z","date_updated":"2026-07-28T11:30:41Z","issue":"13","intvolume":" 45","fulldoi":"https://doi.org/10.1523/JNEUROSCI.1767-23.2024","language":[{"iso":"eng"}],"oa":1,"scopus_import":"1","article_processing_charge":"No","department":[{"_id":"MaDe"}],"author":[{"last_name":"Stratigi","full_name":"Stratigi, Aikaterini","first_name":"Aikaterini"},{"first_name":"Miguel","full_name":"Soler-García, Miguel","last_name":"Soler-García"},{"first_name":"Mia","last_name":"Krout","full_name":"Krout, Mia"},{"first_name":"Shikha","full_name":"Shukla, Shikha","last_name":"Shukla"},{"first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443","full_name":"De Bono, Mario","last_name":"De Bono"},{"last_name":"Richmond","full_name":"Richmond, Janet E.","first_name":"Janet E."},{"full_name":"Laurent, Patrick","last_name":"Laurent","first_name":"Patrick"}],"OA_type":"hybrid","article_number":"e1767232024","_id":"19498","quality_controlled":"1","publication":"Journal of Neuroscience","citation":{"apa":"Stratigi, A., Soler-García, M., Krout, M., Shukla, S., de Bono, M., Richmond, J. E., & Laurent, P. (2025). Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1767-23.2024","ama":"Stratigi A, Soler-García M, Krout M, et al. Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans. Journal of Neuroscience. 2025;45(13). doi:10.1523/JNEUROSCI.1767-23.2024","ieee":"A. Stratigi et al., “Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans,” Journal of Neuroscience, vol. 45, no. 13. Society for Neuroscience, 2025.","ista":"Stratigi A, Soler-García M, Krout M, Shukla S, de Bono M, Richmond JE, Laurent P. 2025. Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans. Journal of Neuroscience. 45(13), e1767232024.","short":"A. Stratigi, M. Soler-García, M. Krout, S. Shukla, M. de Bono, J.E. Richmond, P. Laurent, Journal of Neuroscience 45 (2025).","mla":"Stratigi, Aikaterini, et al. “Neuroendocrine Control of Synaptic Transmission by PHAC-1 in C. Elegans.” Journal of Neuroscience, vol. 45, no. 13, e1767232024, Society for Neuroscience, 2025, doi:10.1523/JNEUROSCI.1767-23.2024.","chicago":"Stratigi, Aikaterini, Miguel Soler-García, Mia Krout, Shikha Shukla, Mario de Bono, Janet E. Richmond, and Patrick Laurent. “Neuroendocrine Control of Synaptic Transmission by PHAC-1 in C. Elegans.” Journal of Neuroscience. Society for Neuroscience, 2025. https://doi.org/10.1523/JNEUROSCI.1767-23.2024."},"day":"26","publication_status":"published","has_accepted_license":"1","file":[{"checksum":"7befc0168f4cd5bd2b0fcff9e2a94784","relation":"main_file","file_name":"2025_JourNeuroscience_Stratigi.pdf","file_id":"19525","embargo":"2025-09-27","date_updated":"2025-09-27T22:30:02Z","file_size":3111735,"creator":"dernst","content_type":"application/pdf","date_created":"2025-04-07T11:57:19Z","access_level":"open_access"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"abstract":[{"text":"A dynamic interplay between fast synaptic signals and slower neuromodulatory signals controls the excitatory/inhibitory (E/I) balance within neuronal circuits. The mechanisms by which neuropeptide signaling is regulated to maintain E/I balance remain uncertain. We designed a genetic screen to isolate genes involved in the peptidergic maintenance of the E/I balance in the C. elegans motor circuit. This screen identified the C. elegans orthologs of the presynaptic phosphoprotein synapsin (snn-1) and the protein phosphatase 1 (PP1) regulatory subunit PHACTR1 (phac-1). We demonstrate that both phac-1 and snn-1 alter the motor behavior of C. elegans, and genetic interactions suggest that SNN-1 contributes to PP1-PHAC-1 holoenzyme signaling. De novo variants of human PHACTR1, associated with early-onset epilepsies [developmental and epileptic encephalopathy 70 (DEE70)], when expressed in C. elegans resulted in constitutive PP1-PHAC-1 holoenzyme activity. Unregulated PP1-PHAC-1 signaling alters the synapsin and actin cytoskeleton and increases neuropeptide release by cholinergic motor neurons, which secondarily affects the presynaptic vesicle cycle. Together, these results clarify the dominant mechanisms of action of the DEE70 alleles and suggest that altered neuropeptide release may alter E/I balance in DEE70.","lang":"eng"}],"year":"2025","title":"Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans","status":"public","acknowledgement":"P.L. is a research associate of the Belgian National Fund for Scientific Research (FRS-FNRS). K.S., M.S.-G., S.S., and P.L. are supported by grants from the FRS-FNRS. This work was supported by an Advanced ERC Grant (269058 ACMO) to M.D.B. We thank the team of Alexander Gottschalk for the snn-1(S9A) strain. We thank the Imaging Facility of the Faculty of Medicine (LiMiF) of the Universite Libre de Bruxelles, supported by FRS-FNRS. This work made use of instruments in the Electron Microscopy Core of the University of Illinois Chicago Research Resources Center as well as the BioCryo facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern's MRSEC program (NSF DMR-2308691). Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440).","OA_place":"publisher","OA_embargo":"6 months","type":"journal_article","month":"03","isi":1,"date_published":"2025-03-26T00:00:00Z","doi":"10.1523/JNEUROSCI.1767-23.2024","external_id":{"pmid":["39919830"],"isi":["001460952700001"]},"publication_identifier":{"eissn":["1529-2401"],"issn":["0270-6474"]}},{"ddc":["530"],"file_date_updated":"2026-01-29T23:30:03Z","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","date_created":"2025-01-24T10:28:39Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","degree_awarded":"PhD","date_updated":"2026-04-16T12:20:43Z","related_material":{"record":[{"id":"6609","relation":"part_of_dissertation","status":"public"},{"id":"8529","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"18953"},{"relation":"part_of_dissertation","id":"10924","status":"public"},{"id":"9114","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"13200"}]},"fulldoi":"https://doi.org/10.15479/at:ista:18871","project":[{"grant_number":"758053","name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"grant_number":"899354","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","call_identifier":"H2020","name":"Quantum Local Area Networks with Superconducting Qubits"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"},{"grant_number":"F07105","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f"}],"language":[{"iso":"eng"}],"department":[{"_id":"JoFi"},{"_id":"GradSch"}],"article_processing_charge":"No","author":[{"id":"3770C838-F248-11E8-B48F-1D18A9856A87","first_name":"Georg M","orcid":"0000-0003-1397-7876","last_name":"Arnold","full_name":"Arnold, Georg M"}],"acknowledged_ssus":[{"_id":"SSU"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"oa":1,"supervisor":[{"last_name":"Fink","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","orcid":"0000-0001-8112-028X"}],"alternative_title":["ISTA Thesis"],"citation":{"ieee":"G. M. Arnold, “Microwave-optic interconnects for superconducting circuits,” Institute of Science and Technology Austria, 2025.","ama":"Arnold GM. Microwave-optic interconnects for superconducting circuits. 2025. doi:10.15479/at:ista:18871","apa":"Arnold, G. M. (2025). Microwave-optic interconnects for superconducting circuits. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:18871","mla":"Arnold, Georg M. Microwave-Optic Interconnects for Superconducting Circuits. Institute of Science and Technology Austria, 2025, doi:10.15479/at:ista:18871.","chicago":"Arnold, Georg M. “Microwave-Optic Interconnects for Superconducting Circuits.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/at:ista:18871.","short":"G.M. Arnold, Microwave-Optic Interconnects for Superconducting Circuits, Institute of Science and Technology Austria, 2025.","ista":"Arnold GM. 2025. Microwave-optic interconnects for superconducting circuits. Institute of Science and Technology Austria."},"day":"24","_id":"18871","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)"},"file":[{"file_name":"tex for upload.zip","embargo_to":"open_access","file_id":"18946","checksum":"71872702e8f46c275eaea44efc4d304f","relation":"source_file","content_type":"application/x-zip-compressed","creator":"cchlebak","date_created":"2025-01-29T08:38:08Z","access_level":"closed","date_updated":"2026-01-29T23:30:03Z","file_size":18856130},{"relation":"main_file","checksum":"dfaa06591970f4bff163705802fad56d","file_id":"18947","file_name":"ISTThesisGA2022_final.pdf","file_size":17344760,"date_updated":"2026-01-29T23:30:03Z","embargo":"2026-01-29","access_level":"open_access","date_created":"2025-01-29T08:38:34Z","creator":"cchlebak","content_type":"application/pdf"}],"has_accepted_license":"1","publication_status":"published","status":"public","title":"Microwave-optic interconnects for superconducting circuits","corr_author":"1","year":"2025","abstract":[{"text":"\"Can we do this with a new type of computer - a quantum computer?\". This famous\r\nquotation of the brilliant Richard Feynman within a conference talk on \"Simulating physics\r\nwith computers.” is often reverently praised as the origin of the field of quantum computing.\r\nThe idea was to use quantum mechanical systems itself to simulate \"Nature\", which is\r\ninherently quantum mechanical. Now, 43 years later, the theoretical framework of how such\r\na computer can operate has been developed. Two main important concepts for a potential\r\nquantum supremacy, superposition and entanglement, have been exploited to design quantum\r\nalgorithms to significantly speed up certain tasks. Yet, the specific hardware implementation\r\nis still far from being certain, in fact the race between the most promising platforms such as\r\nsuperconducting qubits, bosonic codes, cold atoms, trapped ions, optical computing as well\r\nas spin qubits has recently intensified. If one also includes the most mature applications of\r\nquantum communication technologies, secure quantum key distribution and quantum random\r\nnumber generators, as part of a quantum information technology ecosystem, we are confronted\r\nwith a plethora of different materials, concepts, and also operation frequencies. While\r\nsuperconducting qubits, bosonic codes and spin qubits work in the regime of approximately 5\r\nGHz and are controlled by electrical fields, trapped ions, cold atoms, and optical quantum\r\ncomputing operate with light in the infrared or visible range.\r\nConsequently, a quantum frequency converter or microwave-optic transducer is required\r\nto interface the different frequency domains or establish a long-range network connection\r\nwith suitable telecom fibers. In fact, the combination of different frequency regimes is also\r\nan essential part in our classical modern communication network, where computations are\r\nperformed in electrical circuits and the information exchange over longer distances happens\r\nvia optical fibers. However, the specific challenges specific to building a quantum computer,\r\nalso apply to the development of such a quantum frequency transducer: 1) As we deal with\r\nsingle excitations as the carrier of information, i.e. the smallest possible quantity, the signal\r\ncan easily be corrupted by other noise sources which needs to be avoided by all means. This\r\nis also the reason why microwave quantum computers operate at temperature environments\r\nclose to zero temperature (< 0.1 Kelvin) to avoid corruption by thermal noise. 2) The\r\nfrequency interface generally needs to preserve the phase of the signal as an essential part\r\nof the quantum state. And 3) Quantum signals cannot be copied which would be a typical\r\nstrategy to account for errors in classical computers. And finally, there is a challenge specific to\r\nmicrowave-optic transducers: While quantum computers are operating in one specific frequency\r\ndomain, microwave-optic transducers combine microwave and optical fields in one device.\r\nThis results in the particular challenge that high-energy optical radiation, which is usually\r\nwell-shielded from superconducting microwave quantum processors, are now an essential part\r\nof the device. The concomitant optical radiation in the operating transducer will inevitably\r\nhave a detrimental effect on the superconducting microwave components. Together with the\r\nrequirement of minimal background noise for quantum-limited operation as described above,\r\nv\r\nheating from the absorption of optical photons within the same device where single microwave\r\nexcitations are processed forms a formidable challenge.\r\nThis thesis aims to address this challenge by developing microwave-optic transducers where\r\nthe impact of optical absorption on superconducting circuits in general and superconducting\r\nqubits specifically can be mitigated. In our first approach, we developed a compact device\r\nwith optimized interaction strengths between the different frequency domains. This minimizes\r\nthe optical powers used for transducer operation and thus the optical absorption heating. This\r\nwork was - to the best of our knowledge - the first comprehensive noise study, in an integrated\r\nmicrowave-optic transducer. Unfortunately, we saw that the optical absorption heating added\r\nnoise way above a single excitation. Consequently, a potential quantum signal would have\r\nbeen buried in the noise, added by the transduction.\r\nBuilding on this insight, we utilized a three-dimensional microwave-optic transducer instead\r\nof an integrated device. The larger heat capacity of the macroscopic device with a size\r\nof a few millimeters can absorb a larger fraction of the optical heating before it increases\r\nthe temperature of the device. This allowed us to interface the transducer directly with a\r\nsuperconducting qubit to readout the qubit state in a novel all-optical manner. We showed\r\nthat the microwave-optic transducer can be operated in a regime in which optical fields don’t\r\nharm the sensitive qubit. This is an important prerequisite for the operation of microwave-optic\r\ntransducers in conjunction with microwave quantum processors and brings the integration and\r\nseamless orchestration of different frequency components in a quantum network a step closer.\r\n","lang":"eng"}],"OA_place":"publisher","acknowledgement":"This work was supported by the European Research Council under grant agreement no. 758053\r\n(ERC StG QUNNECT) and the European Union’s Horizon 2020 research, innovation program\r\nunder grant agreement no. 899354 (FETopen SuperQuLAN) and the Austrian Science Fund\r\n(FWF) through BeyondC (F7105). I want to acknowledge generous support from the Austrian\r\nAcademy of Sciences from a DOC [Doctoral program of the Austrian Academy of Sciences]\r\nfellowship (no. 25129).\r\n","ec_funded":1,"page":"135","type":"dissertation","month":"01","date_published":"2025-01-24T00:00:00Z","doi":"10.15479/at:ista:18871","publication_identifier":{"issn":["2663-337X"]}},{"date_updated":"2026-06-18T17:34:48Z","related_material":{"record":[{"status":"public","id":"14274","relation":"part_of_dissertation"}]},"date_created":"2025-05-26T08:49:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","degree_awarded":"PhD","publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","ddc":["570"],"file_date_updated":"2025-11-27T23:30:02Z","supervisor":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","full_name":"Sixt, Michael K"}],"author":[{"last_name":"Canigova","full_name":"Canigova, Nikola","orcid":"0000-0002-8518-5926","id":"3795523E-F248-11E8-B48F-1D18A9856A87","first_name":"Nikola"}],"article_processing_charge":"No","department":[{"_id":"MiSi"},{"_id":"GradSch"}],"oa":1,"language":[{"iso":"eng"}],"project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385"},{"name":"Nano-Analytics of Cellular Systems","call_identifier":"FWF","_id":"265E2996-B435-11E9-9278-68D0E5697425","grant_number":"W01250-B20"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-19745","OA_embargo":"6","OA_place":"publisher","acknowledgement":"This project has received funding from the Austrian Science Fund (FWF) via the doctorate\r\ncollege DK NanoCell and from the European Union’s Horizon 2020 research and innovation\r\nprogramme under the Marie Skłodowska-Curie Grant Agreement No. 665385.\r\n","title":"Adaptive strategies of dendritic cell migration in response to environmental cues","status":"public","corr_author":"1","abstract":[{"lang":"eng","text":"Cell migration is a crucial process in animal development and maintenance. It is incredibly\r\nheterogeneous, with different cell types utilizing fundamentally distinct migration strategies.\r\nThe strategies also depend on the cellular microenvironment, where cells can switch between\r\nmigration modes as they encounter new environmental cues. In this thesis, we investigated\r\nhow dendritic cells adapt their migration strategy when encountering geometrically,\r\nmechanically and chemically distinct environments.\r\nWhen dendritic cells are embedded in a homogeneous fibrous network, they migrate in a fast\r\nand directional amoeboid manner. In this migration strategy, extracellular proteolysis and\r\nintegrin-mediated adhesions are dispensable. Instead, the cells use topography of the\r\nenvironment to propel their cell body forward. To migrate efficiently in the maze of different\r\npore sizes, they position the nucleus ahead of the microtubule organizing center (MTOC) and\r\nuse it to gauge the pores to identify the path of least resistance. Our aim was to identify\r\nwhether dendritic cells adapt their migration strategy when encountering asymmetrical\r\ntransitions into much denser environments with limited choice of large pores. In such invasive\r\ntransitions it is unclear if the cells can cross tight pores without the use of adhesions and\r\nextracellular proteolysis and whether they maintain the nucleus in the cell front.\r\nUsing various cell migration assays such as fibrous 3D collagen gels, geometrically defined\r\nmicrochannels with constrictions and simplistic under agarose migration assay, we provide\r\na comprehensive characterization of invasive migration of dendritic cells. We show that\r\nduring invasion the cells stall and stretch, reflecting the difficulty to translocate the bulky cell\r\nbody into the dense environment. In collagen gels, we show that dendritic cells can invade\r\nwithout proteolysis and adhesions. Instead, they utilize contractility, which can lead to largescale collagen compressions. During invasion, the nucleus stalls at tight constrictions, leading\r\nto a transient organelle reorientation. To resolve the stalling, upregulated rear contractility is\r\nrequired. This contractile force is simultaneously necessary for reverting the nucleus back to\r\nthe cell front after invasion and maintaining this positioning during permissive migration.\r\nA functional role of the reorientation was uncovered in the first collaboration project.\r\nA prominent central actin pool was identified around the MTOC, especially pronounced in\r\ndense and compressive environments. The actin pool was shown to generate pushing forces\r\nto dilate the space for cell translocation. These forces are only necessary in non-permissive\r\nenvironments, where the nucleus reorients to the cell rear, allowing the actin pool to\r\ngenerate space. In permissive environments where space generation is dispensable, the\r\nMTOC is located behind the nucleus and the actin cloud has reduced intensity, allowing more\r\nactin to be incorporated into the lamellipodium, speeding up migration.\r\nIn the second collaboration project, we investigated the effects of distinct chemical\r\nenvironments on dendritic cell migration. The strikingly persistent migration of these cells\r\nwas explained by their ability to modulate and even self-generate chemokine gradients. This\r\nallows the cells to migrate faster and more persistent in uniform chemokine fields compared\r\nto imposed chemokine gradients. The chemokine receptor CCR7 was identified as a crucial\r\nplayer in this process, both sensing the signal and internalizing the chemokine to create a sink."}],"year":"2025","file":[{"file_name":"NikolaCanigova_Thesis_final.docx","embargo_to":"open_access","file_id":"19748","checksum":"1a2d1525d19347fbb879ef57c02951bf","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"cchlebak","date_created":"2025-05-28T07:38:17Z","access_level":"closed","date_updated":"2025-11-27T23:30:02Z","file_size":103879193},{"file_id":"19749","file_name":"NikolaCanigova_Thesis_final_PDFA2a_fixed.pdf","relation":"main_file","checksum":"c1d8f9a40a8e19fcf895373f4b773a46","access_level":"open_access","date_created":"2025-05-28T07:39:53Z","content_type":"application/pdf","creator":"cchlebak","file_size":194530600,"date_updated":"2025-11-27T23:30:02Z","embargo":"2025-11-27"}],"publication_status":"published","has_accepted_license":"1","day":"27","citation":{"apa":"Canigova, N. (2025). Adaptive strategies of dendritic cell migration in response to environmental cues. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19745","ieee":"N. Canigova, “Adaptive strategies of dendritic cell migration in response to environmental cues,” Institute of Science and Technology Austria, 2025.","ama":"Canigova N. Adaptive strategies of dendritic cell migration in response to environmental cues. 2025. doi:10.15479/AT-ISTA-19745","ista":"Canigova N. 2025. Adaptive strategies of dendritic cell migration in response to environmental cues. Institute of Science and Technology Austria.","short":"N. Canigova, Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues, Institute of Science and Technology Austria, 2025.","chicago":"Canigova, Nikola. “Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19745.","mla":"Canigova, Nikola. Adaptive Strategies of Dendritic Cell Migration in Response to Environmental Cues. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19745."},"alternative_title":["ISTA Thesis"],"_id":"19745","publication_identifier":{"isbn":["978-3-99078-058-9"],"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-19745","date_published":"2025-05-27T00:00:00Z","month":"05","ec_funded":1,"page":"133","type":"dissertation"},{"publication_identifier":{"eissn":["2663-337X"],"isbn":["978-3-99078-055-8"]},"doi":"10.15479/10.15479/AT-ISTA-19431","date_published":"2025-03-20T00:00:00Z","month":"03","type":"dissertation","page":"83","acknowledgement":"I would also like to acknowledge the ISTA Facilities: Lab Support Facility, Protein Services and Electron Microscopy Facility (EMF) and Scientific Computing. EMF for their support during data collections and troubleshooting, especially Valentin. Scientific Computing for solving quickly any issues related with cluster.","OA_place":"publisher","abstract":[{"lang":"eng","text":"Gene expression is crucial for cell differentiation, development and survival of\r\norganisms. It consists of several steps, starting with transcription that is mediated by\r\nRNA polymerases. These are protein machineries transcribing and producing different\r\ntypes of RNAs. Although, the individual steps of transcription by RNA polymerase II\r\n(Pol II) as well as the structure of Pol II has been extensively studied, surprisingly,\r\nthere is still little known about its regulation and assembly in cytoplasm. Among the\r\nproteins that are important in biogenesis of Pol II are RNA polymerase II associating\r\nproteins (RPAP) and small GPN-loop GTPases (GPN). Both of these protein groups\r\nwere shown to take essential part in assembly of Pol II.\r\nThe aim of this project was to deepen our knowledge in regulation of Pol II in\r\nthe cytoplasm as well as the proteins involved in this process. Techniques of structural\r\nbiology, biochemistry and cell biology were employed to study and characterize cytoplasmic Pol II and its interacting partners.\r\nThis study shows for the first time the structure of cytoplasmic Pol II at high\r\nresolution. The structure also reveals proteins interacting with Pol II in cytoplasm,\r\nnamely GDOWN1, RPAP2. Comparing the structure of cytoplasmic Pol II with transcribing Pol II revealed striking difference in clamp region that is not in closed state.\r\nFurthermore, GDOWN1 and RPAP2 make steric clashes with various transcription\r\nfactors bound to Pol II during different stages of transcription. Even though GPN1 and\r\nGPN3 proteins were not resolved in the cytoplasmic Pol II structure, they are part of\r\nthe complex and their interaction with Pol II was confirmed in vitro. RPAP2 stabilizes\r\nthese proteins on Pol II and several experiments suggest that they interact with the\r\nclamp region. In addition, GDOWN1, RPAP2 and GPNs might keep clamp in open or\r\npartially open state. Based on these results I propose a novel model of regulation of\r\nPol II in cytoplasm. GDOWN1, RPAP2, GPN1 and GPN3 bind to Pol II in cytoplasm\r\nand doing so they can prevent pre-mature binding of DNA or RNA and different transcription factors to Pol II in cytoplasm or before engaging in transcription nucleus.\r\nThis research contributes to the current knowledge of molecular mechanisms\r\nof Pol II regulation in cytoplasm."}],"year":"2025","corr_author":"1","status":"public","title":"Regulation of Cytoplasmic RNA Polymerase II","publication_status":"published","has_accepted_license":"1","file":[{"access_level":"closed","date_created":"2025-03-24T12:48:36Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"ahlavata","file_size":23506747,"date_updated":"2026-03-20T23:30:04Z","file_id":"19448","embargo_to":"open_access","file_name":"PhD_Thesis_Hlavata_final_submission.docx","relation":"source_file","checksum":"b7ddf424ffe95f8c767c53c8bb62d4f3"},{"checksum":"6c5a59c9bac467c3d0b3ffb8ea6d9fd4","relation":"main_file","file_id":"19449","file_name":"PhD_Thesis_Hlavata_final_submission_update.pdf","date_updated":"2026-03-20T23:30:04Z","file_size":9478591,"embargo":"2026-03-20","date_created":"2025-03-24T12:51:10Z","access_level":"open_access","creator":"ahlavata","content_type":"application/pdf"}],"_id":"19431","alternative_title":["ISTA Thesis"],"day":"20","citation":{"apa":"Hlavata, A. (2025). Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria. https://doi.org/10.15479/10.15479/AT-ISTA-19431","ama":"Hlavata A. Regulation of Cytoplasmic RNA Polymerase II. 2025. doi:10.15479/10.15479/AT-ISTA-19431","ieee":"A. Hlavata, “Regulation of Cytoplasmic RNA Polymerase II,” Institute of Science and Technology Austria, 2025.","ista":"Hlavata A. 2025. Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria.","short":"A. Hlavata, Regulation of Cytoplasmic RNA Polymerase II, Institute of Science and Technology Austria, 2025.","mla":"Hlavata, Annamaria. Regulation of Cytoplasmic RNA Polymerase II. Institute of Science and Technology Austria, 2025, doi:10.15479/10.15479/AT-ISTA-19431.","chicago":"Hlavata, Annamaria. “Regulation of Cytoplasmic RNA Polymerase II.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/10.15479/AT-ISTA-19431."},"supervisor":[{"last_name":"Bernecky","full_name":"Bernecky, Carrie A","orcid":"0000-0003-0893-7036","id":"2CB9DFE2-F248-11E8-B48F-1D18A9856A87","first_name":"Carrie A"}],"oa":1,"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"EM-Fac"},{"_id":"ScienComp"}],"article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"CaBe"}],"author":[{"last_name":"Hlavata","full_name":"Hlavata, Annamaria","id":"36062FEC-F248-11E8-B48F-1D18A9856A87","first_name":"Annamaria"}],"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.15479/10.15479/AT-ISTA-19431","date_updated":"2026-04-07T11:46:32Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","degree_awarded":"PhD","date_created":"2025-03-20T12:52:47Z","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","file_date_updated":"2026-03-20T23:30:04Z","ddc":["572"]},{"publication_identifier":{"eissn":["2663-337X"]},"date_published":"2025-02-24T00:00:00Z","doi":"10.15479/AT-ISTA-19302","month":"02","type":"dissertation","page":"85","ec_funded":1,"acknowledgement":"Thank you to the Lab Support Facility at ISTA. Thank you to the European Research Council (ERC) for their funding under the European Union’s Horizon 2020 research and innovation program (ERC Consolidator Grant EPIDEMICSonCHIP, No. 771402, to Sylvia Cremer, and ERC Starting Grant DISEASE, No. 802628, to Nathalie Stroeymeyt).","year":"2025","abstract":[{"lang":"eng","text":"Social interaction networks of insect colonies facilitate efficient information exchange and\r\ndemonstrate adaptive changes to mitigate disease transmission. While circadian rhythms\r\ninfluence individual behaviour, their role in shaping colony-level defences against pathogens\r\nremains unexplored. Here, we investigate whether social networks of the black garden ant,\r\nLasius niger, exhibit circadian rhythms and how these rhythms influence disease vulnerability\r\nwhen colonies are exposed to a pathogen during the day or the night.\r\nWe first establish baseline daily variations in activity and network dynamics in pathogen-free\r\ncolonies, revealing constitutive daily fluctuations in disease susceptibility. Subsequently, we\r\nexamine pathogen-induced changes in sanitary care and network dynamics by exposing\r\nforagers to a natural pathogen (Metarhizium brunneum) during either the day or the night.\r\nIndividual pathogen loads were measured after a nine-hour post-exposure period to evaluate\r\ntransmission outcomes.\r\nOur results demonstrate that diurnal ant colonies maintain robust circadian patterns in network\r\nproperties while flexibly adapting to pathogen exposure. Ants upregulate sanitary care\r\nirrespective of exposure timing, prioritising the protection of the valuable colony centre\r\nconsisting of nurses and the queen. These findings underscore the robustness and adaptability\r\nof ant colonies in balancing circadian rhythms with effective social immune responses."}],"corr_author":"1","title":"The effect of circadian rhythm on organisational immunity of ant colonies","status":"public","publication_status":"published","has_accepted_license":"1","file":[{"file_name":"Thesis_Linda_Sartoris.docx","embargo_to":"open_access","file_id":"19310","checksum":"7e9466dcf3681454211b74b5107e9f7b","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","creator":"lsartori","date_created":"2025-03-07T10:16:11Z","access_level":"closed","date_updated":"2026-02-23T23:30:03Z","file_size":7129583},{"creator":"lsartori","content_type":"application/pdf","date_created":"2025-03-11T10:42:20Z","access_level":"closed","description":"for printing purposes only","date_updated":"2026-03-02T23:31:13Z","file_size":3199703,"file_name":"thesis_Sartoris_for_print.pdf","embargo_to":"open_access","file_id":"19384","checksum":"2ccfcf32f0590bb0ec1a488e606a73f5","relation":"other"},{"file_name":"Thesis_Linda_Sartoris.pdf","file_id":"19385","checksum":"1d1f3c1279065b1a7f407ff6d1ee1503","relation":"main_file","creator":"lsartori","content_type":"application/pdf","date_created":"2025-03-11T10:52:00Z","access_level":"open_access","embargo":"2026-02-23","date_updated":"2026-02-23T23:30:03Z","file_size":3183186}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"_id":"19302","citation":{"ama":"Sartoris L. The effect of circadian rhythm on organisational immunity of ant colonies. 2025. doi:10.15479/AT-ISTA-19302","ieee":"L. Sartoris, “The effect of circadian rhythm on organisational immunity of ant colonies,” Institute of Science and Technology Austria, 2025.","apa":"Sartoris, L. (2025). The effect of circadian rhythm on organisational immunity of ant colonies. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19302","mla":"Sartoris, Linda. The Effect of Circadian Rhythm on Organisational Immunity of Ant Colonies. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19302.","chicago":"Sartoris, Linda. “The Effect of Circadian Rhythm on Organisational Immunity of Ant Colonies.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19302.","short":"L. Sartoris, The Effect of Circadian Rhythm on Organisational Immunity of Ant Colonies, Institute of Science and Technology Austria, 2025.","ista":"Sartoris L. 2025. The effect of circadian rhythm on organisational immunity of ant colonies. Institute of Science and Technology Austria."},"day":"24","alternative_title":["ISTA Thesis"],"supervisor":[{"full_name":"Cremer, Sylvia","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"}],"oa":1,"acknowledged_ssus":[{"_id":"LifeSc"}],"article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"SyCr"}],"author":[{"full_name":"Sartoris, Linda","last_name":"Sartoris","first_name":"Linda","id":"2B9284CA-F248-11E8-B48F-1D18A9856A87"}],"OA_type":"closed access","language":[{"iso":"eng"}],"project":[{"name":"Epidemics in ant societies on a chip","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"771402"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-19302","date_updated":"2026-03-02T23:31:14Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","degree_awarded":"PhD","date_created":"2025-03-06T12:16:54Z","oa_version":"Published Version","publisher":"Institute of Science and Technology Austria","ddc":["577"],"file_date_updated":"2026-03-02T23:31:13Z"},{"month":"02","page":"96","type":"dissertation","publication_identifier":{"isbn":["978-3-99078-056-5"],"issn":["2663-337X"]},"keyword":["neuroscience","decision making","learning","cognitive flexibility","medial prefrontal cortex","hippocampus","electrophysiology"],"date_published":"2025-02-18T00:00:00Z","doi":"10.15479/AT-ISTA-19456","file":[{"creator":"acumpeli","content_type":"application/pdf","date_created":"2025-03-25T11:07:55Z","access_level":"open_access","embargo":"2025-09-30","date_updated":"2025-09-30T22:30:02Z","file_size":11869040,"file_name":"2025_Thesis_Cumpelik_corrections_PDFA.pdf","file_id":"19457","checksum":"1c7573303d8e5f6da3eb03d59055390f","relation":"main_file"},{"file_id":"19458","embargo_to":"open_access","file_name":"2025_Thesis_Cumpelik_corrections.docx","relation":"source_file","checksum":"b93265ebd9a53f7a14100d0d48b4ff5b","access_level":"closed","date_created":"2025-03-25T11:08:05Z","creator":"acumpeli","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":20436467,"date_updated":"2025-09-30T22:30:02Z"}],"has_accepted_license":"1","publication_status":"published","citation":{"chicago":"Cumpelik, Andrea D. “The Role of Prefrontal Spatial Coding in Supporting a Contextual Association Task.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19456.","mla":"Cumpelik, Andrea D. The Role of Prefrontal Spatial Coding in Supporting a Contextual Association Task. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19456.","short":"A.D. Cumpelik, The Role of Prefrontal Spatial Coding in Supporting a Contextual Association Task, Institute of Science and Technology Austria, 2025.","ista":"Cumpelik AD. 2025. The role of prefrontal spatial coding in supporting a contextual association task. Institute of Science and Technology Austria.","ieee":"A. D. Cumpelik, “The role of prefrontal spatial coding in supporting a contextual association task,” Institute of Science and Technology Austria, 2025.","ama":"Cumpelik AD. The role of prefrontal spatial coding in supporting a contextual association task. 2025. doi:10.15479/AT-ISTA-19456","apa":"Cumpelik, A. D. (2025). The role of prefrontal spatial coding in supporting a contextual association task. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19456"},"day":"18","alternative_title":["ISTA Thesis"],"_id":"19456","OA_embargo":"6 months","OA_place":"publisher","corr_author":"1","status":"public","title":"The role of prefrontal spatial coding in supporting a contextual association task","abstract":[{"text":"Making decisions requires flexibly adapting to changing environments, a process that\r\ndepends on accurately interpreting current contingencies and integrating them with\r\npast experience. Two brain regions are particularly critical for this process, the medial\r\nprefrontal cortex (mPFC) and the hippocampus. Using contextual information from the\r\nhippocampus, the mPFC selects relevant cognitive frameworks and suppresses\r\nirrelevant ones to guide appropriate actions. Several studies have shown that some\r\nmPFC pyramidal neurons become spatially tuned when spatial information is required\r\nto guide goal-directed behavior. However, the role of prefrontal spatial representations\r\nin learning and decision making is not well understood. This work aims to characterize\r\nthe role of mPFC spatial tuning in supporting a contextual association task. Rats were\r\ntrained to learn two cue–location associations on a radial arm maze over multiple days,\r\nwhile we simultaneously recorded from dorsal CA1 of the hippocampus and the\r\nprelimbic area of the mPFC. We describe a subset of spatially tuned hippocampal and\r\nprefrontal pyramidal neurons that “flicker” between multiple spatial representations on\r\ndifferent trials, suggesting dynamic, context-dependent coding. This flickering may\r\nprovide a substrate for how the network reorganizes in response to task demands,\r\nlikely by enabling the flexible evaluation of competing representations. ","lang":"eng"}],"year":"2025","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-19456","supervisor":[{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"}],"department":[{"_id":"GradSch"},{"_id":"JoCs"}],"article_processing_charge":"No","author":[{"orcid":"0000-0003-1727-6612","first_name":"Andrea D","id":"3F158B32-F248-11E8-B48F-1D18A9856A87","full_name":"Cumpelik, Andrea D","last_name":"Cumpelik"}],"oa":1,"publisher":"Institute of Science and Technology Austria","oa_version":"Published Version","ddc":["612"],"file_date_updated":"2025-09-30T22:30:02Z","date_updated":"2026-04-07T12:37:58Z","date_created":"2025-03-25T11:22:38Z","degree_awarded":"PhD","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"}]