[{"publication":"2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition","project":[{"grant_number":"W1260-N35","name":"Vienna Graduate School on Computational Optimization","_id":"9B9290DE-BA93-11EA-9121-9846C619BF3A"},{"grant_number":"805223","call_identifier":"H2020","name":"Elastic Coordination for Scalable Machine Learning","_id":"268A44D6-B435-11E9-9278-68D0E5697425"}],"year":"2022","title":"How well do sparse ImageNet models transfer?","external_id":{"arxiv":["2111.13445"],"isi":["000870759105034"]},"related_material":{"record":[{"status":"public","id":"13074","relation":"dissertation_contains"}]},"page":"12256-12266","department":[{"_id":"DaAl"},{"_id":"ChLa"}],"conference":{"name":"CVPR: Computer Vision and Pattern Recognition","location":"New Orleans, LA, United States","end_date":"2022-06-24","start_date":"2022-06-18"},"publication_identifier":{"eissn":["2575-7075"]},"article_processing_charge":"No","acknowledgement":"he authors would like to sincerely thank Christoph Lampert and Nir Shavit for fruitful discussions during the development of this work, and Eldar Kurtic for experimental support. EI was supported in part by the FWF DK VGSCO, grant agreement number W1260-N35, while AP and DA acknowledge generous support by the ERC, via Starting Grant 805223 ScaleML.","date_created":"2023-01-16T10:06:00Z","_id":"12299","author":[{"first_name":"Eugenia B","orcid":"0000-0002-7778-3221","last_name":"Iofinova","id":"f9a17499-f6e0-11ea-865d-fdf9a3f77117","full_name":"Iofinova, Eugenia B"},{"full_name":"Peste, Elena-Alexandra","last_name":"Peste","id":"32D78294-F248-11E8-B48F-1D18A9856A87","first_name":"Elena-Alexandra"},{"full_name":"Kurtz, Mark","first_name":"Mark","last_name":"Kurtz"},{"first_name":"Dan-Adrian","orcid":"0000-0003-3650-940X","last_name":"Alistarh","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","full_name":"Alistarh, Dan-Adrian"}],"citation":{"ama":"Iofinova EB, Krumes A, Kurtz M, Alistarh D-A. How well do sparse ImageNet models transfer? In: 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition. Institute of Electrical and Electronics Engineers; 2022:12256-12266. doi:10.1109/cvpr52688.2022.01195","mla":"Iofinova, Eugenia B., et al. “How Well Do Sparse ImageNet Models Transfer?” 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, Institute of Electrical and Electronics Engineers, 2022, pp. 12256–66, doi:10.1109/cvpr52688.2022.01195.","ieee":"E. B. Iofinova, A. Krumes, M. Kurtz, and D.-A. Alistarh, “How well do sparse ImageNet models transfer?,” in 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, New Orleans, LA, United States, 2022, pp. 12256–12266.","ista":"Iofinova EB, Krumes A, Kurtz M, Alistarh D-A. 2022. How well do sparse ImageNet models transfer? 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition. CVPR: Computer Vision and Pattern Recognition, 12256–12266.","chicago":"Iofinova, Eugenia B, Alexandra Krumes, Mark Kurtz, and Dan-Adrian Alistarh. “How Well Do Sparse ImageNet Models Transfer?” In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, 12256–66. Institute of Electrical and Electronics Engineers, 2022. https://doi.org/10.1109/cvpr52688.2022.01195.","short":"E.B. Iofinova, A. Krumes, M. Kurtz, D.-A. Alistarh, in:, 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, Institute of Electrical and Electronics Engineers, 2022, pp. 12256–12266.","apa":"Iofinova, E. B., Krumes, A., Kurtz, M., & Alistarh, D.-A. (2022). How well do sparse ImageNet models transfer? In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (pp. 12256–12266). New Orleans, LA, United States: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/cvpr52688.2022.01195"},"quality_controlled":"1","scopus_import":"1","isi":1,"type":"conference","publisher":"Institute of Electrical and Electronics Engineers","status":"public","date_published":"2022-09-27T00:00:00Z","abstract":[{"lang":"eng","text":"Transfer learning is a classic paradigm by which models pretrained on large “upstream” datasets are adapted to yield good results on “downstream” specialized datasets. Generally, more accurate models on the “upstream” dataset tend to provide better transfer accuracy “downstream”. In this work, we perform an in-depth investigation of this phenomenon in the context of convolutional neural networks (CNNs) trained on the ImageNet dataset, which have been pruned-that is, compressed by sparsifiying their connections. We consider transfer using unstructured pruned models obtained by applying several state-of-the-art pruning methods, including magnitude-based, second-order, regrowth, lottery-ticket, and regularization approaches, in the context of twelve standard transfer tasks. In a nutshell, our study shows that sparse models can match or even outperform the transfer performance of dense models, even at high sparsities, and, while doing so, can lead to significant inference and even training speedups. At the same time, we observe and analyze significant differences in the behaviour of different pruning methods. The code is available at: https://github.com/IST-DASLab/sparse-imagenet-transfer."}],"publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1109/cvpr52688.2022.01195","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2111.13445","open_access":"1"}],"month":"09","oa":1,"language":[{"iso":"eng"}],"ec_funded":1,"arxiv":1,"date_updated":"2026-04-07T13:30:19Z","oa_version":"Preprint","corr_author":"1","day":"27"},{"degree_awarded":"PhD","OA_place":"publisher","page":"112","title":"Genetic basis of flower colour as a model for adaptive evolution","year":"2022","article_processing_charge":"No","date_created":"2022-04-07T08:19:54Z","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-016-9"]},"department":[{"_id":"GradSch"},{"_id":"NiBa"}],"has_accepted_license":"1","citation":{"ama":"Matejovicova L. Genetic basis of flower colour as a model for adaptive evolution. 2022. doi:10.15479/at:ista:11128","mla":"Matejovicova, Lenka. Genetic Basis of Flower Colour as a Model for Adaptive Evolution. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11128.","ista":"Matejovicova L. 2022. Genetic basis of flower colour as a model for adaptive evolution. Institute of Science and Technology Austria.","ieee":"L. Matejovicova, “Genetic basis of flower colour as a model for adaptive evolution,” Institute of Science and Technology Austria, 2022.","chicago":"Matejovicova, Lenka. “Genetic Basis of Flower Colour as a Model for Adaptive Evolution.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11128.","apa":"Matejovicova, L. (2022). Genetic basis of flower colour as a model for adaptive evolution. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11128","short":"L. Matejovicova, Genetic Basis of Flower Colour as a Model for Adaptive Evolution, Institute of Science and Technology Austria, 2022."},"file_date_updated":"2022-04-07T08:11:51Z","_id":"11128","author":[{"full_name":"Matejovicova, Lenka","first_name":"Lenka","id":"2DFDEC72-F248-11E8-B48F-1D18A9856A87","last_name":"Matejovicova"}],"publisher":"Institute of Science and Technology Austria","type":"dissertation","ddc":["576","582"],"abstract":[{"lang":"eng","text":"Although we often see studies focusing on simple or even discrete traits in studies of colouration,\r\nthe variation of “appearance” phenotypes found in nature is often more complex, continuous\r\nand high-dimensional. Therefore, we developed automated methods suitable for large datasets\r\nof genomes and images, striving to account for their complex nature, while minimising human\r\nbias. We used these methods on a dataset of more than 20, 000 plant SNP genomes and\r\ncorresponding fower images from a hybrid zone of two subspecies of Antirrhinum majus with\r\ndistinctly coloured fowers to improve our understanding of the genetic nature of the fower\r\ncolour in our study system.\r\nFirstly, we use the advantage of large numbers of genotyped plants to estimate the haplotypes in\r\nthe main fower colour regulating region. We study colour- and geography-related characteristics\r\nof the estimated haplotypes and how they connect to their relatedness. We show discrepancies\r\nfrom the expected fower colour distributions given the genotype and identify particular\r\nhaplotypes leading to unexpected phenotypes. We also confrm a signifcant defcit of the\r\ndouble recessive recombinant and quite surprisingly, we show that haplotypes of the most\r\nfrequent parental type are much less variable than others.\r\nSecondly, we introduce our pipeline capable of processing tens of thousands of full fower\r\nimages without human interaction and summarising each image into a set of informative scores.\r\nWe show the compatibility of these machine-measured fower colour scores with the previously\r\nused manual scores and study impact of external efect on the resulting scores. Finally, we use\r\nthe machine-measured fower colour scores to ft and examine a phenotype cline across the\r\nhybrid zone in Planoles using full fower images as opposed to discrete, manual scores and\r\ncompare it with the genotypic cline."}],"publication_status":"published","date_published":"2022-04-06T00:00:00Z","status":"public","month":"04","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/at:ista:11128","supervisor":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H"}],"oa_version":"Published Version","alternative_title":["ISTA Thesis"],"date_updated":"2026-04-07T14:12:19Z","oa":1,"language":[{"iso":"eng"}],"day":"06","corr_author":"1","file":[{"relation":"main_file","content_type":"application/pdf","date_updated":"2022-04-07T08:11:34Z","access_level":"open_access","creator":"cchlebak","file_size":11906472,"file_name":"LenkaPhD_Official_PDFA.pdf","file_id":"11129","date_created":"2022-04-07T08:11:34Z","checksum":"e9609bc4e8f8e20146fc1125fd4f1bf7"},{"file_size":23036766,"file_name":"LenkaPhD Official_source.zip","checksum":"99d67040432fd07a225643a212ee8588","date_created":"2022-04-07T08:11:51Z","file_id":"11130","content_type":"application/x-zip-compressed","relation":"source_file","creator":"cchlebak","access_level":"closed","date_updated":"2022-04-07T08:11:51Z"}]},{"department":[{"_id":"GradSch"},{"_id":"TiBr"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-023-7"]},"acknowledgement":"I acknowledge the received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska Curie Grant Agreement No. 665385.","date_created":"2022-09-08T21:53:03Z","article_processing_charge":"No","year":"2022","project":[{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"title":"Existence and density problems in Diophantine geometry: From norm forms to Campana points","related_material":{"record":[{"id":"12076","status":"public","relation":"part_of_dissertation"},{"id":"12077","status":"public","relation":"part_of_dissertation"}]},"OA_place":"publisher","page":"208","degree_awarded":"PhD","type":"dissertation","publisher":"Institute of Science and Technology Austria","author":[{"first_name":"Alec L","last_name":"Shute","id":"440EB050-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1812-2810","full_name":"Shute, Alec L"}],"file_date_updated":"2022-09-12T11:24:21Z","_id":"12072","citation":{"ama":"Shute AL. Existence and density problems in Diophantine geometry: From norm forms to Campana points. 2022. doi:10.15479/at:ista:12072","mla":"Shute, Alec L. Existence and Density Problems in Diophantine Geometry: From Norm Forms to Campana Points. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12072.","ista":"Shute AL. 2022. Existence and density problems in Diophantine geometry: From norm forms to Campana points. Institute of Science and Technology Austria.","ieee":"A. L. Shute, “Existence and density problems in Diophantine geometry: From norm forms to Campana points,” Institute of Science and Technology Austria, 2022.","chicago":"Shute, Alec L. “Existence and Density Problems in Diophantine Geometry: From Norm Forms to Campana Points.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12072.","apa":"Shute, A. L. (2022). Existence and density problems in Diophantine geometry: From norm forms to Campana points. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12072","short":"A.L. Shute, Existence and Density Problems in Diophantine Geometry: From Norm Forms to Campana Points, Institute of Science and Technology Austria, 2022."},"has_accepted_license":"1","supervisor":[{"full_name":"Browning, Timothy D","first_name":"Timothy D","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"}],"doi":"10.15479/at:ista:12072","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"month":"09","status":"public","date_published":"2022-09-08T00:00:00Z","publication_status":"published","abstract":[{"text":"In this thesis, we study two of the most important questions in Arithmetic geometry: that of the existence and density of solutions to Diophantine equations. In order for a Diophantine equation to have any solutions over the rational numbers, it must have solutions everywhere locally, i.e., over R and over Qp for every prime p. The converse, called the Hasse principle, is known to fail in general. However, it is still a central question in Arithmetic geometry to determine for which varieties the Hasse principle does hold. In this work, we establish the Hasse principle for a wide new family of varieties of the form f(t) = NK/Q(x) ̸= 0, where f is a polynomial with integer coefficients and NK/Q denotes the norm\r\nform associated to a number field K. Our results cover products of arbitrarily many linear, quadratic or cubic factors, and generalise an argument of Irving [69], which makes use of the beta sieve of Rosser and Iwaniec. We also demonstrate how our main sieve results can be applied to treat new cases of a conjecture of Harpaz and Wittenberg on locally split values of polynomials over number fields, and discuss consequences for rational points in fibrations.\r\nIn the second question, about the density of solutions, one defines a height function and seeks to estimate asymptotically the number of points of height bounded by B as B → ∞. Traditionally, one either counts rational points, or\r\nintegral points with respect to a suitable model. However, in this thesis, we study an emerging area of interest in Arithmetic geometry known as Campana points, which in some sense interpolate between rational and integral points.\r\nMore precisely, we count the number of nonzero integers z1, z2, z3 such that gcd(z1, z2, z3) = 1, and z1, z2, z3, z1 + z2 + z3 are all squareful and bounded by B. Using the circle method, we obtain an asymptotic formula which agrees in\r\nthe power of B and log B with a bold new generalisation of Manin’s conjecture to the setting of Campana points, recently formulated by Pieropan, Smeets, Tanimoto and Várilly-Alvarado [96]. However, in this thesis we also provide the first known counterexamples to leading constant predicted by their conjecture. ","lang":"eng"}],"ddc":["512"],"file":[{"content_type":"application/pdf","relation":"main_file","date_updated":"2022-09-08T21:50:34Z","creator":"ashute","access_level":"open_access","success":1,"file_name":"Thesis_final_draft.pdf","file_size":1907386,"date_created":"2022-09-08T21:50:34Z","file_id":"12073","checksum":"bf073344320e05d92c224786cec2e92d"},{"relation":"source_file","content_type":"application/octet-stream","date_updated":"2022-09-12T11:24:21Z","access_level":"closed","creator":"ashute","file_size":495393,"file_name":"athesis.tex","file_id":"12074","date_created":"2022-09-08T21:50:42Z","checksum":"b054ac6baa09f70e8235403a4abbed80"},{"relation":"source_file","content_type":"application/x-zip-compressed","date_updated":"2022-09-12T11:24:21Z","access_level":"closed","creator":"ashute","file_name":"qfcjsfmtvtbfrjjvhdzrnqxfvgjvxtbf.zip","file_size":944534,"file_id":"12078","date_created":"2022-09-09T12:05:00Z","checksum":"0a31e905f1cff5eb8110978cc90e1e79"}],"corr_author":"1","day":"08","language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"date_updated":"2026-04-07T14:13:35Z","alternative_title":["ISTA Thesis"],"oa_version":"Published Version"},{"ec_funded":1,"language":[{"iso":"eng"}],"oa":1,"oa_version":"Published Version","date_updated":"2026-04-07T14:13:19Z","alternative_title":["ISTA Thesis"],"corr_author":"1","file":[{"date_created":"2023-01-25T10:52:46Z","file_id":"12369","checksum":"e54a3e69b83ebf166544164afd25608e","success":1,"file_size":14581024,"file_name":"THESIS_FINAL_FArslan_pdfa.pdf","date_updated":"2023-01-25T10:52:46Z","creator":"cchlebak","access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"day":"29","date_published":"2022-09-29T00:00:00Z","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. The \r\nbinding of adhesion receptors and remodeling of the actomyosin cell cortex at cell-cell \r\ninteraction sites have been implicated in cell-cell contact formation. Yet, how these two \r\nprocesses functionally interact to drive cell-cell contact expansion and strengthening \r\nremains unclear. Here, we study how primary germ layer progenitor cells from zebrafish \r\nbind to supported lipid bilayers (SLB) functionalized with E-cadherin ectodomains as an \r\nassay system for monitoring cell-cell contact formation at high spatiotemporal resolution. \r\nWe show that cell-cell contact formation represents a two-tiered process: E-cadherin\u0002mediated downregulation of the small GTPase RhoA at the forming contact leads to both \r\ndepletion of Myosin-2 and decrease of F-actin. This is followed by centrifugal actin \r\nnetwork flows at the contact triggered by a sharp gradient of Myosin-2 at the rim of the \r\ncontact zone, with Myosin-2 displaying higher cortical localization outside than inside of \r\nthe contact. These centrifugal cortical actin flows, in turn, not only further dilute the actin \r\nnetwork at the contact disc, but also lead to an accumulation of both F-actin and E\u0002cadherin at the contact rim. Eventually, this combination of actomyosin downregulation \r\nand flows at the contact contribute to the characteristic molecular organization implicated \r\nin contact formation and maintenance: depletion of cortical actomyosin at the contact disc, \r\ndriving contact expansion by lowering interfacial tension at the contact, and accumulation \r\nof both E-cadherin and F-actin at the contact rim, mechanically linking the contractile \r\ncortices of the adhering cells. Thus, using a biomimetic assay, we exemplify how \r\nadhesion signaling and cell mechanics function together to modulate the spatial \r\norganization of cell-cell contacts."}],"ddc":["570"],"doi":"10.15479/at:ista:12153","supervisor":[{"first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"09","author":[{"first_name":"Feyza N","last_name":"Arslan","id":"49DA7910-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5809-9566","full_name":"Arslan, Feyza N"}],"_id":"12368","file_date_updated":"2023-01-25T10:52:46Z","has_accepted_license":"1","citation":{"short":"F.N. Arslan, Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows, Institute of Science and Technology Austria, 2022.","apa":"Arslan, F. N. (2022). Remodeling of E-cadherin-mediated contacts via cortical flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12153","chicago":"Arslan, Feyza N. “Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12153.","ista":"Arslan FN. 2022. Remodeling of E-cadherin-mediated contacts via cortical flows. Institute of Science and Technology Austria.","ieee":"F. N. Arslan, “Remodeling of E-cadherin-mediated contacts via cortical flows,” Institute of Science and Technology Austria, 2022.","mla":"Arslan, Feyza N. Remodeling of E-Cadherin-Mediated Contacts via Cortical Flows. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12153.","ama":"Arslan FN. Remodeling of E-cadherin-mediated contacts via cortical flows. 2022. doi:10.15479/at:ista:12153"},"type":"dissertation","publisher":"Institute of Science and Technology Austria","title":"Remodeling of E-cadherin-mediated contacts via cortical flows","year":"2022","project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"742573"}],"OA_place":"publisher","page":"113","degree_awarded":"PhD","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"9350"}]},"department":[{"_id":"GradSch"},{"_id":"CaHe"}],"date_created":"2023-01-25T10:43:24Z","article_processing_charge":"No","publication_identifier":{"isbn":["978-3-99078-025-1 "],"issn":["2663-337X"]},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"NanoFab"}]},{"oa_version":"Published Version","date_updated":"2026-04-07T14:12:58Z","issue":"4","oa":1,"language":[{"iso":"eng"}],"day":"22","abstract":[{"lang":"eng","text":"This paper introduces a methodology for inverse-modeling of yarn-level mechanics of cloth, based on the mechanical response of fabrics in the real world. We compiled a database from physical tests of several different knitted fabrics used in the textile industry. These data span different types of complex knit patterns, yarn compositions, and fabric finishes, and the results demonstrate diverse physical properties like stiffness, nonlinearity, and anisotropy.\r\n\r\nWe then develop a system for approximating these mechanical responses with yarn-level cloth simulation. To do so, we introduce an efficient pipeline for converting between fabric-level data and yarn-level simulation, including a novel swatch-level approximation for speeding up computation, and some small-but-necessary extensions to yarn-level models used in computer graphics. The dataset used for this paper can be found at http://mslab.es/projects/YarnLevelFabrics."}],"publication_status":"published","date_published":"2022-07-22T00:00:00Z","status":"public","month":"07","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1145/3528223.3530167"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1145/3528223.3530167","scopus_import":"1","quality_controlled":"1","article_number":"65","citation":{"chicago":"Sperl, Georg, Rosa M. Sánchez-Banderas, Manwen Li, Chris Wojtan, and Miguel A. Otaduy. “Estimation of Yarn-Level Simulation Models for Production Fabrics.” ACM Transactions on Graphics. Association for Computing Machinery, 2022. https://doi.org/10.1145/3528223.3530167.","apa":"Sperl, G., Sánchez-Banderas, R. M., Li, M., Wojtan, C., & Otaduy, M. A. (2022). Estimation of yarn-level simulation models for production fabrics. ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3528223.3530167","short":"G. Sperl, R.M. Sánchez-Banderas, M. Li, C. Wojtan, M.A. Otaduy, ACM Transactions on Graphics 41 (2022).","ama":"Sperl G, Sánchez-Banderas RM, Li M, Wojtan C, Otaduy MA. Estimation of yarn-level simulation models for production fabrics. ACM Transactions on Graphics. 2022;41(4). doi:10.1145/3528223.3530167","ista":"Sperl G, Sánchez-Banderas RM, Li M, Wojtan C, Otaduy MA. 2022. Estimation of yarn-level simulation models for production fabrics. ACM Transactions on Graphics. 41(4), 65.","ieee":"G. Sperl, R. M. Sánchez-Banderas, M. Li, C. Wojtan, and M. A. Otaduy, “Estimation of yarn-level simulation models for production fabrics,” ACM Transactions on Graphics, vol. 41, no. 4. Association for Computing Machinery, 2022.","mla":"Sperl, Georg, et al. “Estimation of Yarn-Level Simulation Models for Production Fabrics.” ACM Transactions on Graphics, vol. 41, no. 4, 65, Association for Computing Machinery, 2022, doi:10.1145/3528223.3530167."},"_id":"11736","author":[{"first_name":"Georg","last_name":"Sperl","id":"4DD40360-F248-11E8-B48F-1D18A9856A87","full_name":"Sperl, Georg"},{"full_name":"Sánchez-Banderas, Rosa M.","first_name":"Rosa M.","last_name":"Sánchez-Banderas"},{"last_name":"Li","first_name":"Manwen","full_name":"Li, Manwen"},{"orcid":"0000-0001-6646-5546","last_name":"Wojtan","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher J","full_name":"Wojtan, Christopher J"},{"first_name":"Miguel A.","last_name":"Otaduy","full_name":"Otaduy, Miguel A."}],"intvolume":" 41","publisher":"Association for Computing Machinery","isi":1,"type":"journal_article","related_material":{"link":[{"url":"https://ista.ac.at/en/news/digital-yarn-real-socks/","description":"News on the ISTA website","relation":"press_release"}],"record":[{"relation":"dissertation_contains","status":"public","id":"12358"}]},"volume":41,"external_id":{"isi":["000830989200114"]},"article_type":"original","title":"Estimation of yarn-level simulation models for production fabrics","publication":"ACM Transactions on Graphics","year":"2022","article_processing_charge":"No","date_created":"2022-08-07T22:01:58Z","acknowledgement":"We wish to thank the anonymous reviewers for their helpful comments. To develop this project, we were helped by many people both at Under Armour (Clay Dean, Randall Harward, Kyle Blakely, Craig Simile, Michael Seiz, Brooke Malone, Brittainy McFarland, Emilie Phan, Lindsey Kern, Courtney Oswald, Haley Barkley, Bob Chin, Adam Bayer, Connie Kwok, Marielle Newman, Nick Pence, Allison Hicks, Allison White, Candace Rubenstein, Jeremy Stangland, Fred Fagergren, Michael Mazzoleni, Nathaniel Berry, Manuel Frank) and SEDDI (Gabriel Cirio, Alejandro Rodríguez, Sofía Dominguez, Alicia Nicas, Elena Garcés, Daniel Rodríguez, David Pascual, Manuel Godoy, Sergio Suja, Sergio Ruiz, Roberto Condori, Alberto Martín, Graham Sullivan). We also thank the members of the Visual Computing Group at IST Austria and the Multimodal Simulation Lab at URJC for their feedback. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by Scientific Computing, and it was funded in part by the European Research Council (ERC Consolidator Grant 772738 TouchDesign).","publication_identifier":{"issn":["0730-0301"],"eissn":["1557-7368"]},"acknowledged_ssus":[{"_id":"ScienComp"}],"department":[{"_id":"ChWo"}]},{"citation":{"ama":"Wild P. High-dimensional expansion and crossing numbers of simplicial complexes. 2022. doi:10.15479/at:ista:11777","ista":"Wild P. 2022. High-dimensional expansion and crossing numbers of simplicial complexes. Institute of Science and Technology Austria.","ieee":"P. Wild, “High-dimensional expansion and crossing numbers of simplicial complexes,” Institute of Science and Technology Austria, 2022.","mla":"Wild, Pascal. High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11777.","chicago":"Wild, Pascal. “High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11777.","apa":"Wild, P. (2022). High-dimensional expansion and crossing numbers of simplicial complexes. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11777","short":"P. Wild, High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes, Institute of Science and Technology Austria, 2022."},"has_accepted_license":"1","author":[{"full_name":"Wild, Pascal","id":"4C20D868-F248-11E8-B48F-1D18A9856A87","last_name":"Wild","first_name":"Pascal"}],"file_date_updated":"2022-08-11T16:09:19Z","_id":"11777","publisher":"Institute of Science and Technology Austria","type":"dissertation","OA_place":"publisher","page":"170","degree_awarded":"PhD","year":"2022","project":[{"grant_number":"665385","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"}],"title":"High-dimensional expansion and crossing numbers of simplicial complexes","publication_identifier":{"isbn":["978-3-99078-021-3"],"issn":["2663-337X"]},"date_created":"2022-08-10T15:51:19Z","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"UlWa"}],"date_updated":"2026-04-07T14:18:26Z","alternative_title":["ISTA Thesis"],"oa_version":"Published Version","ec_funded":1,"language":[{"iso":"eng"}],"oa":1,"day":"11","file":[{"access_level":"open_access","creator":"pwild","date_updated":"2022-08-10T15:34:04Z","description":"Code for computer-assisted proofs in Section 8.4.7 in Thesis","relation":"supplementary_material","content_type":"text/x-python","checksum":"f5f3af1fb7c8a24b71ddc88ad7f7c5b4","file_id":"11780","date_created":"2022-08-10T15:34:04Z","file_name":"flags.py","file_size":16828},{"file_name":"lowerbound.cpp","file_size":12226,"checksum":"1f7c12dfe3bdaa9b147e4fbc3d34e3d5","date_created":"2022-08-10T15:34:10Z","file_id":"11781","content_type":"text/x-c++src","relation":"supplementary_material","creator":"pwild","access_level":"open_access","description":"Code for proof of Lemma 8.20 in Thesis","date_updated":"2022-08-10T15:34:10Z"},{"access_level":"open_access","creator":"pwild","date_updated":"2022-08-10T15:34:17Z","description":"Code for proof of Proposition 7.9 in Thesis","relation":"supplementary_material","content_type":"text/x-python","checksum":"4cf81455c49e5dec3b9b2e3980137eeb","file_id":"11782","date_created":"2022-08-10T15:34:17Z","file_size":3240,"file_name":"upperbound.py"},{"content_type":"application/pdf","title":"High-Dimensional Expansion and Crossing Numbers of Simplicial Complexes","relation":"main_file","creator":"pwild","access_level":"open_access","date_updated":"2022-08-11T16:08:33Z","file_size":5086282,"file_name":"finalthesisPascalWildPDFA.pdf","checksum":"4e96575b10cbe4e0d0db2045b2847774","date_created":"2022-08-11T16:08:33Z","file_id":"11809"},{"content_type":"application/zip","relation":"source_file","creator":"pwild","access_level":"closed","date_updated":"2022-08-11T16:09:19Z","file_name":"ThesisSubmission.zip","file_size":18150068,"checksum":"92d94842a1fb6dca5808448137573b2e","date_created":"2022-08-11T16:09:19Z","file_id":"11810"}],"corr_author":"1","publication_status":"published","abstract":[{"text":"In this dissertation we study coboundary expansion of simplicial complex with a view of giving geometric applications.\r\nOur main novel tool is an equivariant version of Gromov's celebrated Topological Overlap Theorem. The equivariant topological overlap theorem leads to various geometric applications including a quantitative non-embeddability result for sufficiently thick buildings (which partially resolves a conjecture of Tancer and Vorwerk) and an improved lower bound on the pair-crossing number of (bounded degree) expander graphs. Additionally, we will give new proofs for several known lower bounds for geometric problems such as the number of Tverberg partitions or the crossing number of complete bipartite graphs.\r\nFor the aforementioned applications one is naturally lead to study expansion properties of joins of simplicial complexes. In the presence of a special certificate for expansion (as it is the case, e.g., for spherical buildings), the join of two expanders is an expander. On the flip-side, we report quite some evidence that coboundary expansion exhibits very non-product-like behaviour under taking joins. For instance, we exhibit infinite families of graphs $(G_n)_{n\\in \\mathbb{N}}$ and $(H_n)_{n\\in\\mathbb{N}}$ whose join $G_n*H_n$ has expansion of lower order than the product of the expansion constant of the graphs. Moreover, we show an upper bound of $(d+1)/2^d$ on the normalized coboundary expansion constants for the complete multipartite complex $[n]^{*(d+1)}$ (under a mild divisibility condition on $n$).\r\nVia the probabilistic method the latter result extends to an upper bound of $(d+1)/2^d+\\varepsilon$ on the coboundary expansion constant of the spherical building associated with $\\mathrm{PGL}_{d+2}(\\mathbb{F}_q)$ for any $\\varepsilon>0$ and sufficiently large $q=q(\\varepsilon)$. This disproves a conjecture of Lubotzky, Meshulam and Mozes -- in a rather strong sense.\r\nBy improving on existing lower bounds we make further progress towards closing the gap between the known lower and upper bounds on the coboundary expansion constants of $[n]^{*(d+1)}$. The best improvements we achieve using computer-aided proofs and flag algebras. The exact value even for the complete $3$-partite $2$-dimensional complex $[n]^{*3}$ remains unknown but we are happy to conjecture a precise value for every $n$. %Moreover, we show that a previously shown lower bound on the expansion constant of the spherical building associated with $\\mathrm{PGL}_{2}(\\mathbb{F}_q)$ is not tight.\r\nIn a loosely structured, last chapter of this thesis we collect further smaller observations related to expansion. We point out a link between discrete Morse theory and a technique for showing coboundary expansion, elaborate a bit on the hardness of computing coboundary expansion constants, propose a new criterion for coboundary expansion (in a very dense setting) and give one way of making the folklore result that expansion of links is a necessary condition for a simplicial complex to be an expander precise.","lang":"eng"}],"ddc":["500","516","514"],"status":"public","date_published":"2022-08-11T00:00:00Z","month":"08","doi":"10.15479/at:ista:11777","supervisor":[{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","orcid":"0000-0002-1494-0568","first_name":"Uli","full_name":"Wagner, Uli"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"citation":{"mla":"Mysliwy, Krzysztof. Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy Estimates. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11473.","ieee":"K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy estimates,” Institute of Science and Technology Austria, 2022.","ista":"Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous energy estimates. Institute of Science and Technology Austria.","ama":"Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy estimates. 2022. doi:10.15479/at:ista:11473","apa":"Mysliwy, K. (2022). Polarons in Bose gases and polar crystals: Some rigorous energy estimates. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11473","short":"K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy Estimates, Institute of Science and Technology Austria, 2022.","chicago":"Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy Estimates.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11473."},"has_accepted_license":"1","author":[{"full_name":"Mysliwy, Krzysztof","first_name":"Krzysztof","last_name":"Mysliwy","id":"316457FC-F248-11E8-B48F-1D18A9856A87"}],"file_date_updated":"2022-07-05T08:17:12Z","_id":"11473","publisher":"Institute of Science and Technology Austria","type":"dissertation","related_material":{"record":[{"id":"10564","status":"public","relation":"part_of_dissertation"},{"id":"8705","status":"public","relation":"part_of_dissertation"}]},"OA_place":"publisher","page":"138","degree_awarded":"PhD","year":"2022","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020"}],"title":"Polarons in Bose gases and polar crystals: Some rigorous energy estimates","acknowledged_ssus":[{"_id":"SSU"}],"publication_identifier":{"issn":["2663-337X"]},"date_created":"2022-06-30T12:15:03Z","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"RoSe"}],"oa_version":"Published Version","alternative_title":["ISTA Thesis"],"date_updated":"2026-04-07T14:14:52Z","ec_funded":1,"oa":1,"language":[{"iso":"eng"}],"day":"01","file":[{"content_type":"application/pdf","relation":"main_file","creator":"kmysliwy","access_level":"open_access","date_updated":"2022-07-05T08:12:56Z","success":1,"file_size":1830973,"file_name":"thes1_no_isbn_2_1b.pdf","checksum":"7970714a20a6052f75fb27a6c3e9976e","date_created":"2022-07-05T08:12:56Z","file_id":"11486"},{"content_type":"application/zip","relation":"source_file","date_updated":"2022-07-05T08:17:12Z","creator":"kmysliwy","access_level":"closed","file_name":"thes_source.zip","file_size":5831060,"date_created":"2022-07-05T08:15:52Z","file_id":"11487","checksum":"647a2011fdf56277096c9350fefe1097"}],"corr_author":"1","publication_status":"published","abstract":[{"text":"The polaron model is a basic model of quantum field theory describing a single particle\r\ninteracting with a bosonic field. It arises in many physical contexts. We are mostly concerned\r\nwith models applicable in the context of an impurity atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving in polar crystals.\r\nThe model has a simple structure in which the interaction of the particle with the field is given\r\nby a term linear in the field’s creation and annihilation operators. In this work, we investigate\r\nthe properties of this model by providing rigorous estimates on various energies relevant to the\r\nproblem. The estimates are obtained, for the most part, by suitable operator techniques which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe first application of these techniques is to derive the polaron model rigorously from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective theory for this problem.\r\nIn the second part, we investigate rigorously the ground state of the model at fixed momentum\r\nand for large values of the coupling constant. Qualitatively, the system is expected to display\r\na transition from the quasi-particle behavior at small momenta, where the dispersion relation\r\nis parabolic and the particle moves through the medium dragging along a cloud of phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates and emits free phonons.\r\nAt the same time, in the strong coupling regime, the bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst studied by Landau and Pekar in the 1940s. For polaron models with regularized form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in the interacting Bose gas, we prove\r\nthat for a large window of momenta below the radiation threshold, the energy-momentum\r\nrelation at strong coupling is indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons in polar crystals where the dispersion relation is\r\nof the optical type and the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe regular case, this requires the inclusion of the quantum fluctuations of the phonon field,\r\nwhich makes the problem considerably more difficult.\r\nThe results are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na proof of the divergence of the effective mass with the coupling constant for a wide class of\r\npolaron models, as well as the discussion of the apparent UV singularity of the Fröhlich model\r\nand the application of the techniques used for its removal for the energy estimates.\r\n","lang":"eng"}],"ddc":["515","539"],"status":"public","date_published":"2022-07-01T00:00:00Z","month":"07","supervisor":[{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert","full_name":"Seiringer, Robert"}],"doi":"10.15479/at:ista:11473","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"department":[{"_id":"SaSi"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"LifeSc"}],"publication_identifier":{"eissn":["2041-1723"]},"date_created":"2022-08-28T22:01:59Z","acknowledgement":"The authors thank the Scientific Service Units at ISTA, in particular the Molecular Biology Service of the Lab Support Facility, Imaging & Optics Facility, and the Preclinical Facility, and the Novarino group, Harald Janoviak, and Marco Benevento for sharing reagents and expertise. This research was supported by a DOC Fellowship (24979) awarded to R.S. by the Austrian Academy of Sciences.","article_processing_charge":"No","year":"2022","publication":"Nature Communications","project":[{"name":"Modulating microglia through G protein-coupled receptor (GPCR) signaling","_id":"267F75D8-B435-11E9-9278-68D0E5697425"}],"title":"Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses","article_type":"original","external_id":{"isi":["000840984400032"],"pmid":["35970889"]},"volume":13,"related_material":{"link":[{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/dreaddful-mimicry/"}],"record":[{"relation":"research_data","id":"11542","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"11945"}]},"type":"journal_article","isi":1,"publisher":"Springer Nature","intvolume":" 13","author":[{"full_name":"Schulz, Rouven","first_name":"Rouven","id":"4C5E7B96-F248-11E8-B48F-1D18A9856A87","last_name":"Schulz","orcid":"0000-0001-5297-733X"},{"full_name":"Korkut, Medina","last_name":"Korkut","id":"4B51CE74-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4309-2251","first_name":"Medina"},{"full_name":"Venturino, Alessandro","first_name":"Alessandro","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","last_name":"Venturino","orcid":"0000-0003-2356-9403"},{"full_name":"Colombo, Gloria","last_name":"Colombo","id":"3483CF6C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9434-8902","first_name":"Gloria"},{"first_name":"Sandra","orcid":"0000-0001-8635-0877","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","last_name":"Siegert","full_name":"Siegert, Sandra"}],"_id":"11995","file_date_updated":"2022-08-29T06:44:30Z","citation":{"short":"R. Schulz, M. Korkut, A. Venturino, G. Colombo, S. Siegert, Nature Communications 13 (2022).","apa":"Schulz, R., Korkut, M., Venturino, A., Colombo, G., & Siegert, S. (2022). Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-32390-1","chicago":"Schulz, Rouven, Medina Korkut, Alessandro Venturino, Gloria Colombo, and Sandra Siegert. “Chimeric GPCRs Mimic Distinct Signaling Pathways and Modulate Microglia Responses.” Nature Communications. Springer Nature, 2022. https://doi.org/10.1038/s41467-022-32390-1.","ieee":"R. Schulz, M. Korkut, A. Venturino, G. Colombo, and S. Siegert, “Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses,” Nature Communications, vol. 13. Springer Nature, 2022.","ista":"Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. 2022. Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. Nature Communications. 13, 4728.","mla":"Schulz, Rouven, et al. “Chimeric GPCRs Mimic Distinct Signaling Pathways and Modulate Microglia Responses.” Nature Communications, vol. 13, 4728, Springer Nature, 2022, doi:10.1038/s41467-022-32390-1.","ama":"Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. Nature Communications. 2022;13. doi:10.1038/s41467-022-32390-1"},"has_accepted_license":"1","scopus_import":"1","article_number":"4728","quality_controlled":"1","pmid":1,"doi":"10.1038/s41467-022-32390-1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"08","status":"public","date_published":"2022-08-15T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"G protein-coupled receptors (GPCRs) regulate processes ranging from immune responses to neuronal signaling. However, ligands for many GPCRs remain unknown, suffer from off-target effects or have poor bioavailability. Additionally, dissecting cell type-specific responses is challenging when the same GPCR is expressed on different cells within a tissue. Here, we overcome these limitations by engineering DREADD-based GPCR chimeras that bind clozapine-N-oxide and mimic a GPCR-of-interest. We show that chimeric DREADD-β2AR triggers responses comparable to β2AR on second messenger and kinase activity, post-translational modifications, and protein-protein interactions. Moreover, we successfully recapitulate β2AR-mediated filopodia formation in microglia, an immune cell capable of driving central nervous system inflammation. When dissecting microglial inflammation, we included two additional DREADD-based chimeras mimicking microglia-enriched GPR65 and GPR109A. DREADD-β2AR and DREADD-GPR65 modulate the inflammatory response with high similarity to endogenous β2AR, while DREADD-GPR109A shows no impact. Our DREADD-based approach allows investigation of cell type-dependent pathways without known endogenous ligands."}],"ddc":["570"],"file":[{"checksum":"191d9db0266e14a28d3a56dc7f65da84","date_created":"2022-08-29T06:44:30Z","file_id":"12002","success":1,"file_name":"2022_NatComm_Schulz.pdf","file_size":7317396,"creator":"cchlebak","access_level":"open_access","date_updated":"2022-08-29T06:44:30Z","content_type":"application/pdf","relation":"main_file"}],"corr_author":"1","day":"15","oa":1,"language":[{"iso":"eng"}],"date_updated":"2026-04-07T14:17:58Z","oa_version":"Published Version"},{"day":"01","file":[{"relation":"main_file","content_type":"application/pdf","date_updated":"2022-02-02T14:24:41Z","access_level":"open_access","creator":"cchlebak","file_name":"2022_JournalStatPhys_Myśliwy.pdf","file_size":434957,"success":1,"file_id":"10716","date_created":"2022-02-02T14:24:41Z","checksum":"da03f6d293c4b9802091bce9471b1d29"}],"corr_author":"1","arxiv":1,"issue":"1","oa_version":"Published Version","date_updated":"2026-04-07T14:14:51Z","ec_funded":1,"oa":1,"language":[{"iso":"eng"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"01","doi":"10.1007/s10955-021-02851-w","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"We study a class of polaron-type Hamiltonians with sufficiently regular form factor in the interaction term. We investigate the strong-coupling limit of the model, and prove suitable bounds on the ground state energy as a function of the total momentum of the system. These bounds agree with the semiclassical approximation to leading order. The latter corresponds here to the situation when the particle undergoes harmonic motion in a potential well whose frequency is determined by the corresponding Pekar functional. We show that for all such models the effective mass diverges in the strong coupling limit, in all spatial dimensions. Moreover, for the case when the phonon dispersion relation grows at least linearly with momentum, the bounds result in an asymptotic formula for the effective mass quotient, a quantity generalizing the usual notion of the effective mass. This asymptotic form agrees with the semiclassical Landau–Pekar formula and can be regarded as the first rigorous confirmation, in a slightly weaker sense than usually considered, of the validity of the semiclassical formula for the effective mass.","lang":"eng"}],"publication_status":"published","ddc":["530"],"status":"public","date_published":"2022-01-01T00:00:00Z","publisher":"Springer Nature","intvolume":" 186","type":"journal_article","isi":1,"citation":{"chicago":"Mysliwy, Krzysztof, and Robert Seiringer. “Polaron Models with Regular Interactions at Strong Coupling.” Journal of Statistical Physics. Springer Nature, 2022. https://doi.org/10.1007/s10955-021-02851-w.","short":"K. Mysliwy, R. Seiringer, Journal of Statistical Physics 186 (2022).","apa":"Mysliwy, K., & Seiringer, R. (2022). Polaron models with regular interactions at strong coupling. Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-021-02851-w","ama":"Mysliwy K, Seiringer R. Polaron models with regular interactions at strong coupling. Journal of Statistical Physics. 2022;186(1). doi:10.1007/s10955-021-02851-w","mla":"Mysliwy, Krzysztof, and Robert Seiringer. “Polaron Models with Regular Interactions at Strong Coupling.” Journal of Statistical Physics, vol. 186, no. 1, 5, Springer Nature, 2022, doi:10.1007/s10955-021-02851-w.","ista":"Mysliwy K, Seiringer R. 2022. Polaron models with regular interactions at strong coupling. Journal of Statistical Physics. 186(1), 5.","ieee":"K. Mysliwy and R. Seiringer, “Polaron models with regular interactions at strong coupling,” Journal of Statistical Physics, vol. 186, no. 1. Springer Nature, 2022."},"has_accepted_license":"1","article_number":"5","quality_controlled":"1","scopus_import":"1","author":[{"full_name":"Mysliwy, Krzysztof","last_name":"Mysliwy","id":"316457FC-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof"},{"full_name":"Seiringer, Robert","first_name":"Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"_id":"10564","file_date_updated":"2022-02-02T14:24:41Z","publication_identifier":{"eissn":["1572-9613"],"issn":["0022-4715"]},"acknowledgement":"Financial support through the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme Grant Agreement No. 694227 (R.S.) and the Maria Skłodowska-Curie Grant Agreement No. 665386 (K.M.) is gratefully acknowledged. Open access funding provided by Institute of Science and Technology (IST Austria).","date_created":"2021-12-19T23:01:32Z","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"RoSe"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"11473","status":"public"}]},"year":"2022","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","call_identifier":"H2020","grant_number":"694227"},{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"publication":"Journal of Statistical Physics","external_id":{"arxiv":["2106.09328"],"isi":["000726275600001"]},"article_type":"original","title":"Polaron models with regular interactions at strong coupling","volume":186},{"publisher":"Institute of Science and Technology Austria","type":"dissertation","has_accepted_license":"1","citation":{"ama":"Schulz R. Chimeric G protein-coupled receptors mimic distinct signaling pathways and modulate microglia function. 2022. doi:10.15479/at:ista:11945","mla":"Schulz, Rouven. Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling Pathways and Modulate Microglia Function. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11945.","ista":"Schulz R. 2022. Chimeric G protein-coupled receptors mimic distinct signaling pathways and modulate microglia function. Institute of Science and Technology Austria.","ieee":"R. Schulz, “Chimeric G protein-coupled receptors mimic distinct signaling pathways and modulate microglia function,” Institute of Science and Technology Austria, 2022.","chicago":"Schulz, Rouven. “Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling Pathways and Modulate Microglia Function.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11945.","apa":"Schulz, R. (2022). Chimeric G protein-coupled receptors mimic distinct signaling pathways and modulate microglia function. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11945","short":"R. Schulz, Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling Pathways and Modulate Microglia Function, Institute of Science and Technology Austria, 2022."},"author":[{"id":"4C5E7B96-F248-11E8-B48F-1D18A9856A87","last_name":"Schulz","orcid":"0000-0001-5297-733X","first_name":"Rouven","full_name":"Schulz, Rouven"}],"file_date_updated":"2022-08-25T09:33:31Z","_id":"11945","date_created":"2022-08-23T11:33:11Z","article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"}],"department":[{"_id":"GradSch"},{"_id":"SaSi"}],"OA_place":"publisher","page":"133","degree_awarded":"PhD","related_material":{"record":[{"status":"public","id":"11995","relation":"dissertation_contains"}]},"title":"Chimeric G protein-coupled receptors mimic distinct signaling pathways and modulate microglia function","year":"2022","project":[{"name":"Modulating microglia through G protein-coupled receptor (GPCR) signaling","_id":"267F75D8-B435-11E9-9278-68D0E5697425"}],"day":"23","corr_author":"1","file":[{"date_updated":"2022-08-25T08:59:57Z","access_level":"open_access","creator":"rschulz","relation":"main_file","content_type":"application/pdf","file_id":"11970","date_created":"2022-08-25T08:59:57Z","checksum":"61b1b666a210ff7cdd0e95ea75207a13","file_name":"Thesis_Rouven_Schulz_2022_final.pdf","file_size":28079331,"success":1},{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","date_updated":"2022-08-25T09:33:31Z","creator":"rschulz","access_level":"closed","file_name":"Thesis_Rouven_Schulz_2022_final.docx","file_size":27226963,"date_created":"2022-08-25T09:00:11Z","file_id":"11971","checksum":"2b8f95ea1c134dbdb927b41b1dbeeeb5"}],"date_updated":"2026-04-07T14:17:59Z","alternative_title":["ISTA Thesis"],"oa_version":"Published Version","oa":1,"language":[{"iso":"eng"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"08","doi":"10.15479/at:ista:11945","supervisor":[{"first_name":"Sandra","orcid":"0000-0001-8635-0877","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","last_name":"Siegert","full_name":"Siegert, Sandra"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","abstract":[{"text":"G protein-coupled receptors (GPCRs) respond to specific ligands and regulate multiple processes ranging from cell growth and immune responses to neuronal signal transmission. However, ligands for many GPCRs remain unknown, suffer from off-target effects or have poor bioavailability. Additional challenges exist to dissect cell-type specific responses when the same GPCR is expressed on several cell types within the body. Here, we overcome these limitations by engineering DREADD-based GPCR chimeras that selectively bind their agonist clozapine-N-oxide (CNO) and mimic a GPCR-of-interest in a desired cell type.\r\nWe validated our approach with β2-adrenergic receptor (β2AR/ADRB2) and show that our chimeric DREADD-β2AR triggers comparable responses on second messenger and kinase activity, post-translational modifications, and protein-protein interactions. Since β2AR is also enriched in microglia, which can drive inflammation in the central nervous system, we expressed chimeric DREADD-β2AR in primary microglia and successfully recapitulate β2AR-mediated filopodia formation through CNO stimulation. To dissect the role of selected GPCRs during microglial inflammation, we additionally generated DREADD-based chimeras for microglia-enriched GPR65 and GPR109A/HCAR2. In a microglia cell line, DREADD-β2AR and DREADD-GPR65 both modulated the inflammatory response with a similar profile as endogenously expressed β2AR, while DREADD-GPR109A showed no impact.\r\nOur DREADD-based approach provides the means to obtain mechanistic and functional insights into GPCR signaling on a cell-type specific level.","lang":"eng"}],"ddc":["570"],"date_published":"2022-08-23T00:00:00Z","status":"public"},{"_id":"11626","file_date_updated":"2022-07-25T11:48:45Z","author":[{"orcid":"0000-0003-1286-7368","id":"35A03822-F248-11E8-B48F-1D18A9856A87","last_name":"Gallei","first_name":"Michelle C","full_name":"Gallei, Michelle C"}],"citation":{"chicago":"Gallei, Michelle C. “Auxin and Strigolactone Non-Canonical Signaling Regulating Development in Arabidopsis Thaliana.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11626.","apa":"Gallei, M. C. (2022). Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis thaliana. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11626","short":"M.C. Gallei, Auxin and Strigolactone Non-Canonical Signaling Regulating Development in Arabidopsis Thaliana, Institute of Science and Technology Austria, 2022.","ama":"Gallei MC. Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis thaliana. 2022. doi:10.15479/at:ista:11626","ieee":"M. C. Gallei, “Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis thaliana,” Institute of Science and Technology Austria, 2022.","mla":"Gallei, Michelle C. Auxin and Strigolactone Non-Canonical Signaling Regulating Development in Arabidopsis Thaliana. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11626.","ista":"Gallei MC. 2022. Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis thaliana. Institute of Science and Technology Austria."},"has_accepted_license":"1","type":"dissertation","publisher":"Institute of Science and Technology Austria","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"}],"year":"2022","title":"Auxin and strigolactone non-canonical signaling regulating development in Arabidopsis thaliana","related_material":{"record":[{"id":"8138","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"7142","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"6260"},{"relation":"part_of_dissertation","status":"public","id":"10411"},{"relation":"part_of_dissertation","id":"8931","status":"public"},{"relation":"part_of_dissertation","id":"7465","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"9287"}]},"degree_awarded":"PhD","page":"248","OA_place":"publisher","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-019-0"]},"article_processing_charge":"No","date_created":"2022-07-20T11:21:53Z","ec_funded":1,"language":[{"iso":"eng"}],"oa":1,"alternative_title":["ISTA Thesis"],"date_updated":"2026-04-07T14:18:58Z","oa_version":"Published Version","file":[{"date_created":"2022-07-25T09:08:47Z","file_id":"11645","checksum":"bd7ac35403cf5b4b2607287d2a104b3a","file_size":9730864,"file_name":"Thesis_Gallei.pdf","date_updated":"2022-07-25T09:08:47Z","creator":"mgallei","access_level":"open_access","content_type":"application/pdf","relation":"main_file"},{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","date_updated":"2022-07-25T09:39:58Z","creator":"mgallei","access_level":"closed","file_size":19560720,"file_name":"Thesis_Gallei_source.docx","date_created":"2022-07-25T09:09:09Z","file_id":"11646","checksum":"a9e54fe5471ba25dc13c2150c1b8ccbb"},{"content_type":"application/pdf","relation":"source_file","description":"This is the print version of the thesis including the full appendix","date_updated":"2022-07-25T09:39:58Z","creator":"mgallei","access_level":"closed","file_name":"Thesis_Gallei_to_print.pdf","file_size":24542837,"date_created":"2022-07-25T09:09:32Z","file_id":"11647","checksum":"3994f7f20058941b5bb8a16886b21e71"},{"date_created":"2022-07-25T11:48:45Z","file_id":"11650","checksum":"f24acd3c0d864f4c6676e8b0d7bfa76b","file_size":15435966,"file_name":"Thesis_Gallei_Appendix.pdf","date_updated":"2022-07-25T11:48:45Z","creator":"mgallei","access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"corr_author":"1","day":"20","status":"public","date_published":"2022-07-20T00:00:00Z","ddc":["575"],"abstract":[{"lang":"eng","text":"Plant growth and development is well known to be both, flexible and dynamic. The high capacity for post-embryonic organ formation and tissue regeneration requires tightly regulated intercellular communication and coordinated tissue polarization. One of the most important drivers for patterning and polarity in plant development is the phytohormone auxin. Auxin has the unique characteristic to establish polarized channels for its own active directional cell to cell transport. This fascinating phenomenon is called auxin canalization. Those auxin transport channels are characterized by the expression and polar, subcellular localization of PIN auxin efflux carriers. PIN proteins have the ability to dynamically change their localization and auxin itself can affect this by interfering with trafficking. Most of the underlying molecular mechanisms of canalization still remain enigmatic. What is known so far is that canonical auxin signaling is indispensable but also other non-canonical signaling components are thought to play a role. In order to shed light into the mysteries auf auxin canalization this study revisits the branches of auxin signaling in detail. Further a new auxin analogue, PISA, is developed which triggers auxin-like responses but does not directly activate canonical transcriptional auxin signaling. We revisit the direct auxin effect on PIN trafficking where we found that, contradictory to previous observations, auxin is very specifically promoting endocytosis of PIN2 but has no overall effect on endocytosis. Further, we evaluate which cellular processes related to PIN subcellular dynamics are involved in the establishment of auxin conducting channels and the formation of vascular tissue. We are re-evaluating the function of AUXIN BINDING PROTEIN 1 (ABP1) and provide a comprehensive picture about its developmental phneotypes and involvement in auxin signaling and canalization. Lastly, we are focusing on the crosstalk between the hormone strigolactone (SL) and auxin and found that SL is interfering with essentially all processes involved in auxin canalization in a non-transcriptional manner. Lastly we identify a new way of SL perception and signaling which is emanating from mitochondria, is independent of canonical SL signaling and is modulating primary root growth."}],"publication_status":"published","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/at:ista:11626","supervisor":[{"full_name":"Friml, Jiří","first_name":"Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"full_name":"Benková, Eva","last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","first_name":"Eva"},{"full_name":"Shani, Eilon","last_name":"Shani","first_name":"Eilon"}],"month":"07"},{"department":[{"_id":"JiFr"}],"publication_identifier":{"issn":["1360-1385"]},"article_processing_charge":"No","acknowledgement":"The authors thank Alexandra Mally for editing the text. This work was supported by the Austrian Science Fund (FWF) I 3630-B25 to Jiří Friml and the DOC Fellowship of the Austrian Academy of Sciences to Lanxin Li. All figures were created with BioRender.com.","date_created":"2021-12-05T23:01:43Z","publication":"Trends in Plant Science","project":[{"name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425","grant_number":"I03630","call_identifier":"FWF"},{"grant_number":"25351","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root","_id":"26B4D67E-B435-11E9-9278-68D0E5697425"}],"year":"2022","volume":27,"title":"Bending to auxin: Fast acid growth for tropisms","article_type":"original","external_id":{"isi":["000793707900005"],"pmid":["34848141"]},"related_material":{"record":[{"relation":"dissertation_contains","id":"11626","status":"public"}]},"page":"440-449","isi":1,"type":"journal_article","publisher":"Cell Press","intvolume":" 27","file_date_updated":"2023-11-02T17:00:03Z","_id":"10411","author":[{"last_name":"Li","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","first_name":"Lanxin","full_name":"Li, Lanxin"},{"full_name":"Gallei, Michelle C","orcid":"0000-0003-1286-7368","last_name":"Gallei","id":"35A03822-F248-11E8-B48F-1D18A9856A87","first_name":"Michelle C"},{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří"}],"citation":{"ista":"Li L, Gallei MC, Friml J. 2022. Bending to auxin: Fast acid growth for tropisms. Trends in Plant Science. 27(5), 440–449.","mla":"Li, Lanxin, et al. “Bending to Auxin: Fast Acid Growth for Tropisms.” Trends in Plant Science, vol. 27, no. 5, Cell Press, 2022, pp. 440–49, doi:10.1016/j.tplants.2021.11.006.","ieee":"L. Li, M. C. Gallei, and J. Friml, “Bending to auxin: Fast acid growth for tropisms,” Trends in Plant Science, vol. 27, no. 5. Cell Press, pp. 440–449, 2022.","ama":"Li L, Gallei MC, Friml J. Bending to auxin: Fast acid growth for tropisms. Trends in Plant Science. 2022;27(5):440-449. doi:10.1016/j.tplants.2021.11.006","short":"L. Li, M.C. Gallei, J. Friml, Trends in Plant Science 27 (2022) 440–449.","apa":"Li, L., Gallei, M. C., & Friml, J. (2022). Bending to auxin: Fast acid growth for tropisms. Trends in Plant Science. Cell Press. https://doi.org/10.1016/j.tplants.2021.11.006","chicago":"Li, Lanxin, Michelle C Gallei, and Jiří Friml. “Bending to Auxin: Fast Acid Growth for Tropisms.” Trends in Plant Science. Cell Press, 2022. https://doi.org/10.1016/j.tplants.2021.11.006."},"quality_controlled":"1","scopus_import":"1","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"doi":"10.1016/j.tplants.2021.11.006","month":"05","status":"public","date_published":"2022-05-01T00:00:00Z","ddc":["580"],"abstract":[{"text":"The phytohormone auxin is the major growth regulator governing tropic responses including gravitropism. Auxin build-up at the lower side of stimulated shoots promotes cell expansion, whereas in roots it inhibits growth, leading to upward shoot bending and downward root bending, respectively. Yet it remains an enigma how the same signal can trigger such opposite cellular responses. In this review, we discuss several recent unexpected insights into the mechanisms underlying auxin regulation of growth, challenging several existing models. We focus on the divergent mechanisms of apoplastic pH regulation in shoots and roots revisiting the classical Acid Growth Theory and discuss coordinated involvement of multiple auxin signaling pathways. From this emerges a more comprehensive, updated picture how auxin regulates growth.","lang":"eng"}],"publication_status":"published","file":[{"date_updated":"2023-11-02T17:00:03Z","creator":"amally","access_level":"open_access","content_type":"application/pdf","relation":"main_file","date_created":"2023-11-02T17:00:03Z","file_id":"14480","checksum":"3d94980ee1ff6bec100dd813f6a921a6","success":1,"file_name":"Li Plants 2021_accepted.pdf","file_size":805779}],"corr_author":"1","day":"01","oa":1,"language":[{"iso":"eng"}],"date_updated":"2026-04-07T14:18:57Z","oa_version":"Submitted Version","issue":"5"},{"date_updated":"2026-04-07T14:19:48Z","oa_version":"Published Version","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"day":"08","file":[{"success":1,"file_name":"thesis.pdf","file_size":4204905,"date_created":"2022-03-06T11:42:54Z","file_id":"10823","checksum":"626bc523ae8822d20e635d0e2d95182e","content_type":"application/pdf","relation":"main_file","date_updated":"2022-03-06T11:42:54Z","creator":"nkonstan","access_level":"open_access"},{"relation":"source_file","content_type":"application/x-zip-compressed","date_updated":"2022-03-10T12:11:48Z","access_level":"closed","creator":"nkonstan","file_size":22841103,"file_name":"thesis.zip","file_id":"10824","date_created":"2022-03-06T11:42:57Z","checksum":"e2ca2b88350ac8ea1515b948885cbcb1"}],"corr_author":"1","abstract":[{"lang":"eng","text":"Because of the increasing popularity of machine learning methods, it is becoming important to understand the impact of learned components on automated decision-making systems and to guarantee that their consequences are beneficial to society. In other words, it is necessary to ensure that machine learning is sufficiently trustworthy to be used in real-world applications. This thesis studies two properties of machine learning models that are highly desirable for the\r\nsake of reliability: robustness and fairness. In the first part of the thesis we study the robustness of learning algorithms to training data corruption. Previous work has shown that machine learning models are vulnerable to a range\r\nof training set issues, varying from label noise through systematic biases to worst-case data manipulations. This is an especially relevant problem from a present perspective, since modern machine learning methods are particularly data hungry and therefore practitioners often have to rely on data collected from various external sources, e.g. from the Internet, from app users or via crowdsourcing. Naturally, such sources vary greatly in the quality and reliability of the\r\ndata they provide. With these considerations in mind, we study the problem of designing machine learning algorithms that are robust to corruptions in data coming from multiple sources. We show that, in contrast to the case of a single dataset with outliers, successful learning within this model is possible both theoretically and practically, even under worst-case data corruptions. The second part of this thesis deals with fairness-aware machine learning. There are multiple areas where machine learning models have shown promising results, but where careful considerations are required, in order to avoid discrimanative decisions taken by such learned components. Ensuring fairness can be particularly challenging, because real-world training datasets are expected to contain various forms of historical bias that may affect the learning process. In this thesis we show that data corruption can indeed render the problem of achieving fairness impossible, by tightly characterizing the theoretical limits of fair learning under worst-case data manipulations. However, assuming access to clean data, we also show how fairness-aware learning can be made practical in contexts beyond binary classification, in particular in the challenging learning to rank setting."}],"publication_status":"published","ddc":["000"],"status":"public","date_published":"2022-03-08T00:00:00Z","month":"03","supervisor":[{"full_name":"Lampert, Christoph","first_name":"Christoph","orcid":"0000-0001-8622-7887","last_name":"Lampert","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.15479/at:ista:10799","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ista":"Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute of Science and Technology Austria.","ieee":"N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute of Science and Technology Austria, 2022.","mla":"Konstantinov, Nikola H. Robustness and Fairness in Machine Learning. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10799.","ama":"Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:10.15479/at:ista:10799","short":"N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute of Science and Technology Austria, 2022.","apa":"Konstantinov, N. H. (2022). Robustness and fairness in machine learning. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10799","chicago":"Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10799."},"keyword":["robustness","fairness","machine learning","PAC learning","adversarial learning"],"has_accepted_license":"1","author":[{"full_name":"Konstantinov, Nikola H","orcid":"0009-0009-5204-7621","last_name":"Konstantinov","id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87","first_name":"Nikola H"}],"_id":"10799","file_date_updated":"2022-03-10T12:11:48Z","publisher":"Institute of Science and Technology Austria","type":"dissertation","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"10802"},{"id":"10803","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"6590","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"8724"}]},"OA_place":"publisher","page":"176","degree_awarded":"PhD","year":"2022","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"}],"title":"Robustness and fairness in machine learning","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-015-2"]},"date_created":"2022-02-28T13:03:49Z","article_processing_charge":"No","department":[{"_id":"GradSch"},{"_id":"ChLa"}]},{"day":"01","file":[{"relation":"main_file","content_type":"application/pdf","date_updated":"2022-07-12T15:08:28Z","access_level":"open_access","creator":"kschuh","file_name":"2022_JournalMachineLearningResearch_Konstantinov.pdf","file_size":551862,"success":1,"file_id":"11570","date_created":"2022-07-12T15:08:28Z","checksum":"9cac897b54a0ddf3a553a2c33e88cfda"}],"corr_author":"1","arxiv":1,"date_updated":"2026-04-07T14:19:48Z","oa_version":"Published Version","language":[{"iso":"eng"}],"oa":1,"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Addressing fairness concerns about machine learning models is a crucial step towards their long-term adoption in real-world automated systems. While many approaches have been developed for training fair models from data, little is known about the robustness of these methods to data corruption. In this work we consider fairness-aware learning under worst-case data manipulations. We show that an adversary can in some situations force any learner to return an overly biased classifier, regardless of the sample size and with or without degrading\r\naccuracy, and that the strength of the excess bias increases for learning problems with underrepresented protected groups in the data. We also prove that our hardness results are tight up to constant factors. To this end, we study two natural learning algorithms that optimize for both accuracy and fairness and show that these algorithms enjoy guarantees that are order-optimal in terms of the corruption ratio and the protected groups frequencies in the large data\r\nlimit.","lang":"eng"}],"publication_status":"published","ddc":["004"],"status":"public","date_published":"2022-05-01T00:00:00Z","publisher":"ML Research Press","intvolume":" 23","type":"journal_article","citation":{"short":"N.H. Konstantinov, C. Lampert, Journal of Machine Learning Research 23 (2022) 1–60.","apa":"Konstantinov, N. H., & Lampert, C. (2022). Fairness-aware PAC learning from corrupted data. Journal of Machine Learning Research. ML Research Press.","chicago":"Konstantinov, Nikola H, and Christoph Lampert. “Fairness-Aware PAC Learning from Corrupted Data.” Journal of Machine Learning Research. ML Research Press, 2022.","ista":"Konstantinov NH, Lampert C. 2022. Fairness-aware PAC learning from corrupted data. Journal of Machine Learning Research. 23, 1–60.","ieee":"N. H. Konstantinov and C. Lampert, “Fairness-aware PAC learning from corrupted data,” Journal of Machine Learning Research, vol. 23. ML Research Press, pp. 1–60, 2022.","mla":"Konstantinov, Nikola H., and Christoph Lampert. “Fairness-Aware PAC Learning from Corrupted Data.” Journal of Machine Learning Research, vol. 23, ML Research Press, 2022, pp. 1–60.","ama":"Konstantinov NH, Lampert C. Fairness-aware PAC learning from corrupted data. Journal of Machine Learning Research. 2022;23:1-60."},"keyword":["Fairness","robustness","data poisoning","trustworthy machine learning","PAC learning"],"has_accepted_license":"1","quality_controlled":"1","scopus_import":"1","author":[{"full_name":"Konstantinov, Nikola H","first_name":"Nikola H","orcid":"0009-0009-5204-7621","last_name":"Konstantinov","id":"4B9D76E4-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Lampert, Christoph","orcid":"0000-0002-4561-241X","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","last_name":"Lampert","first_name":"Christoph"}],"_id":"10802","file_date_updated":"2022-07-12T15:08:28Z","publication_identifier":{"eissn":["1533-7928"],"issn":["1532-4435"]},"date_created":"2022-02-28T14:05:42Z","acknowledgement":"The authors thank Eugenia Iofinova and Bernd Prach for providing feedback on early versions of this paper. This publication was made possible by an ETH AI Center postdoctoral fellowship to Nikola Konstantinov.","article_processing_charge":"No","department":[{"_id":"ChLa"}],"related_material":{"record":[{"status":"public","id":"13241","relation":"shorter_version"},{"id":"10799","status":"public","relation":"dissertation_contains"}]},"page":"1-60","year":"2022","publication":"Journal of Machine Learning Research","external_id":{"arxiv":["2102.06004"]},"article_type":"original","title":"Fairness-aware PAC learning from corrupted data","volume":23},{"publication_identifier":{"issn":["2663-337X"]},"article_processing_charge":"No","date_created":"2022-02-16T13:27:37Z","department":[{"_id":"GradSch"},{"_id":"MiLe"}],"related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"10762"},{"id":"415","status":"public","relation":"part_of_dissertation"},{"id":"8644","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"7956"}]},"degree_awarded":"PhD","page":"120","OA_place":"publisher","project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"}],"year":"2022","title":"Analytic and machine learning approaches to composite quantum impurities","publisher":"Institute of Science and Technology Austria","type":"dissertation","citation":{"mla":"Rzadkowski, Wojciech. Analytic and Machine Learning Approaches to Composite Quantum Impurities. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10759.","ista":"Rzadkowski W. 2022. Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria.","ieee":"W. Rzadkowski, “Analytic and machine learning approaches to composite quantum impurities,” Institute of Science and Technology Austria, 2022.","ama":"Rzadkowski W. Analytic and machine learning approaches to composite quantum impurities. 2022. doi:10.15479/at:ista:10759","apa":"Rzadkowski, W. (2022). Analytic and machine learning approaches to composite quantum impurities. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10759","short":"W. Rzadkowski, Analytic and Machine Learning Approaches to Composite Quantum Impurities, Institute of Science and Technology Austria, 2022.","chicago":"Rzadkowski, Wojciech. “Analytic and Machine Learning Approaches to Composite Quantum Impurities.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10759."},"has_accepted_license":"1","file_date_updated":"2022-02-22T07:20:12Z","_id":"10759","author":[{"first_name":"Wojciech","orcid":"0000-0002-1106-4419","last_name":"Rzadkowski","id":"48C55298-F248-11E8-B48F-1D18A9856A87","full_name":"Rzadkowski, Wojciech"}],"month":"02","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","supervisor":[{"orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","last_name":"Lemeshko","first_name":"Mikhail","full_name":"Lemeshko, Mikhail"}],"doi":"10.15479/at:ista:10759","ddc":["530"],"abstract":[{"text":"In this Thesis, I study composite quantum impurities with variational techniques, both inspired by machine learning as well as fully analytic. I supplement this with exploration of other applications of machine learning, in particular artificial neural networks, in many-body physics. In Chapters 3 and 4, I study quasiparticle systems with variational approach. I derive a Hamiltonian describing the angulon quasiparticle in the presence of a magnetic field. I apply analytic variational treatment to this Hamiltonian. Then, I introduce a variational approach for non-additive systems, based on artificial neural networks. I exemplify this approach on the example of the polaron quasiparticle (Fröhlich Hamiltonian). In Chapter 5, I continue using artificial neural networks, albeit in a different setting. I apply artificial neural networks to detect phases from snapshots of two types physical systems. Namely, I study Monte Carlo snapshots of multilayer classical spin models as well as molecular dynamics maps of colloidal systems. The main type of networks that I use here are convolutional neural networks, known for their applicability to image data.","lang":"eng"}],"publication_status":"published","status":"public","date_published":"2022-02-21T00:00:00Z","day":"21","file":[{"file_name":"Rzadkowski_thesis_final_source.zip","file_size":17668233,"checksum":"0fc54ad1eaede879c665ac9b53c93e22","date_created":"2022-02-21T13:58:16Z","file_id":"10785","content_type":"application/zip","relation":"source_file","creator":"wrzadkow","access_level":"closed","date_updated":"2022-02-22T07:20:12Z"},{"file_id":"10786","date_created":"2022-02-21T14:02:54Z","checksum":"22d2d7af37ca31f6b1730c26cac7bced","file_size":13307331,"file_name":"Rzadkowski_thesis_final.pdf","success":1,"date_updated":"2022-02-21T14:02:54Z","access_level":"open_access","creator":"wrzadkow","relation":"main_file","content_type":"application/pdf"}],"corr_author":"1","oa_version":"Published Version","alternative_title":["ISTA Thesis"],"date_updated":"2026-04-07T14:20:12Z","language":[{"iso":"eng"}],"ec_funded":1,"oa":1},{"abstract":[{"text":"Adversarial training (i.e., training on adversarially perturbed input data) is a well-studied method for making neural networks robust to potential adversarial attacks during inference. However, the improved robustness does not\r\ncome for free but rather is accompanied by a decrease in overall model accuracy and performance. Recent work has shown that, in practical robot learning applications, the effects of adversarial training do not pose a fair trade-off\r\nbut inflict a net loss when measured in holistic robot performance. This work revisits the robustness-accuracy trade-off in robot learning by systematically analyzing if recent advances in robust training methods and theory in\r\nconjunction with adversarial robot learning can make adversarial training suitable for real-world robot applications. We evaluate a wide variety of robot learning tasks ranging from autonomous driving in a high-fidelity environment\r\namenable to sim-to-real deployment, to mobile robot gesture recognition. Our results demonstrate that, while these techniques make incremental improvements on the trade-off on a relative scale, the negative side-effects caused by\r\nadversarial training still outweigh the improvements by an order of magnitude. We conclude that more substantial advances in robust learning methods are necessary before they can benefit robot learning tasks in practice.","lang":"eng"}],"publication_status":"draft","date_published":"2022-04-15T00:00:00Z","status":"public","month":"04","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2204.07373"}],"doi":"10.48550/arXiv.2204.07373","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","date_updated":"2026-04-07T14:21:58Z","arxiv":1,"language":[{"iso":"eng"}],"oa":1,"ec_funded":1,"day":"15","corr_author":"1","OA_place":"repository","related_material":{"record":[{"relation":"later_version","id":"12704","status":"public"},{"relation":"dissertation_contains","id":"11362","status":"public"}]},"external_id":{"arxiv":["2204.07373"]},"title":"Revisiting the adversarial robustness-accuracy tradeoff in robot learning","year":"2022","project":[{"grant_number":"101020093","call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software"}],"publication":"arXiv","acknowledgement":"This work was supported in parts by the ERC-2020-AdG 101020093, National Science Foundation (NSF), and JP\r\nMorgan Graduate Fellowships. We thank Christoph Lampert for inspiring this work.\r\n","date_created":"2022-05-12T13:20:17Z","article_processing_charge":"No","department":[{"_id":"ToHe"}],"article_number":"2204.07373","citation":{"apa":"Lechner, M., Amini, A., Rus, D., & Henzinger, T. A. (n.d.). Revisiting the adversarial robustness-accuracy tradeoff in robot learning. arXiv. https://doi.org/10.48550/arXiv.2204.07373","short":"M. Lechner, A. Amini, D. Rus, T.A. Henzinger, ArXiv (n.d.).","chicago":"Lechner, Mathias, Alexander Amini, Daniela Rus, and Thomas A Henzinger. “Revisiting the Adversarial Robustness-Accuracy Tradeoff in Robot Learning.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2204.07373.","mla":"Lechner, Mathias, et al. “Revisiting the Adversarial Robustness-Accuracy Tradeoff in Robot Learning.” ArXiv, 2204.07373, doi:10.48550/arXiv.2204.07373.","ista":"Lechner M, Amini A, Rus D, Henzinger TA. Revisiting the adversarial robustness-accuracy tradeoff in robot learning. arXiv, 2204.07373.","ieee":"M. Lechner, A. Amini, D. Rus, and T. A. Henzinger, “Revisiting the adversarial robustness-accuracy tradeoff in robot learning,” arXiv. .","ama":"Lechner M, Amini A, Rus D, Henzinger TA. Revisiting the adversarial robustness-accuracy tradeoff in robot learning. arXiv. doi:10.48550/arXiv.2204.07373"},"author":[{"full_name":"Lechner, Mathias","first_name":"Mathias","last_name":"Lechner","id":"3DC22916-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Alexander","last_name":"Amini","full_name":"Amini, Alexander"},{"last_name":"Rus","first_name":"Daniela","full_name":"Rus, Daniela"},{"first_name":"Thomas A","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2985-7724","full_name":"Henzinger, Thomas A"}],"_id":"11366","type":"preprint"},{"day":"28","publisher":"Zenodo","corr_author":"1","type":"research_data_reference","oa_version":"Published Version","date_updated":"2026-04-15T06:39:00Z","has_accepted_license":"1","citation":{"ista":"Zemlicka M, Redchenko E, Peruzzo M, Hassani F, Trioni A, Barzanjeh S, Fink JM. 2022. Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses, Zenodo, 10.5281/ZENODO.8408897.","mla":"Zemlicka, Martin, et al. Compact Vacuum Gap Transmon Qubits: Selective and Sensitive Probes for Superconductor Surface Losses. Zenodo, 2022, doi:10.5281/ZENODO.8408897.","ieee":"M. Zemlicka et al., “Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses.” Zenodo, 2022.","ama":"Zemlicka M, Redchenko E, Peruzzo M, et al. Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses. 2022. doi:10.5281/ZENODO.8408897","short":"M. Zemlicka, E. Redchenko, M. Peruzzo, F. Hassani, A. Trioni, S. Barzanjeh, J.M. Fink, (2022).","apa":"Zemlicka, M., Redchenko, E., Peruzzo, M., Hassani, F., Trioni, A., Barzanjeh, S., & Fink, J. M. (2022). Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses. Zenodo. https://doi.org/10.5281/ZENODO.8408897","chicago":"Zemlicka, Martin, Elena Redchenko, Matilda Peruzzo, Farid Hassani, Andrea Trioni, Shabir Barzanjeh, and Johannes M Fink. “Compact Vacuum Gap Transmon Qubits: Selective and Sensitive Probes for Superconductor Surface Losses.” Zenodo, 2022. https://doi.org/10.5281/ZENODO.8408897."},"oa":1,"_id":"14520","author":[{"id":"2DCF8DE6-F248-11E8-B48F-1D18A9856A87","last_name":"Zemlicka","orcid":"0009-0005-0878-3032","first_name":"Martin","full_name":"Zemlicka, Martin"},{"id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","last_name":"Redchenko","first_name":"Elena","full_name":"Redchenko, Elena"},{"full_name":"Peruzzo, Matilda","first_name":"Matilda","orcid":"0000-0002-3415-4628","id":"3F920B30-F248-11E8-B48F-1D18A9856A87","last_name":"Peruzzo"},{"full_name":"Hassani, Farid","first_name":"Farid","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","last_name":"Hassani","orcid":"0000-0001-6937-5773"},{"first_name":"Andrea","last_name":"Trioni","id":"42F71B44-F248-11E8-B48F-1D18A9856A87","full_name":"Trioni, Andrea"},{"orcid":"0000-0003-0415-1423","last_name":"Barzanjeh","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","first_name":"Shabir","full_name":"Barzanjeh, Shabir"},{"full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","last_name":"Fink","first_name":"Johannes M"}],"article_processing_charge":"No","month":"06","date_created":"2023-11-13T08:09:10Z","tmp":{"legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","image":"/images/cc_0.png","short":"CC0 (1.0)"},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/ZENODO.8408897"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JoFi"}],"doi":"10.5281/ZENODO.8408897","ddc":["530"],"abstract":[{"lang":"eng","text":"This dataset comprises all data shown in the figures of the submitted article \"Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses\" at arxiv.org/abs/2206.14104. Additional raw data are available from the corresponding author on reasonable request."}],"related_material":{"record":[{"status":"public","id":"14517","relation":"used_in_publication"}]},"date_published":"2022-06-28T00:00:00Z","title":"Compact vacuum gap transmon qubits: Selective and sensitive probes for superconductor surface losses","status":"public","year":"2022"},{"volume":12,"external_id":{"pmid":["35477739"],"isi":["000788639400032"]},"article_type":"original","title":"Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia","publication":"Scientific Reports","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411"},{"grant_number":"I05127","_id":"34e076d6-11ca-11ed-8bc3-aec76c41a181","name":"Evolutionary analysis of gene regulation"}],"year":"2022","department":[{"_id":"FyKo"}],"article_processing_charge":"No","date_created":"2022-05-02T07:08:42Z","acknowledgement":"The project was initiated with Aygul Minnegalieva and Yulia Yakovleva at the Summer School of Molecular and Theoretical Biology (SMTB-2020), supported by the Zimin Foundation. We thank Inna Shapovalenko, Daria Abuzova, Elizaveta Kaminskaya, and Dmitriy Zvezdin for their contribution to the project during SMTB-2020. We also thank Peter Vlasov for fruitful discussions.This study was supported by the Russian Foundation for Basic Research (RFBR), Grant # 20-54-14005 and Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Grant # I5127-B. The work of OB is supported by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No. 754411. ","publication_identifier":{"issn":["2045-2322"]},"_id":"11344","file_date_updated":"2022-05-02T09:05:20Z","author":[{"first_name":"NO","last_name":"Dranenko","full_name":"Dranenko, NO"},{"last_name":"Tutukina","first_name":"MN","full_name":"Tutukina, MN"},{"full_name":"Gelfand, MS","first_name":"MS","last_name":"Gelfand"},{"full_name":"Kondrashov, Fyodor","first_name":"Fyodor","orcid":"0000-0001-8243-4694","last_name":"Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bochkareva, Olga","id":"C4558D3C-6102-11E9-A62E-F418E6697425","last_name":"Bochkareva","orcid":"0000-0003-1006-6639","first_name":"Olga"}],"article_number":"6868","quality_controlled":"1","scopus_import":"1","has_accepted_license":"1","citation":{"mla":"Dranenko, NO, et al. “Chromosome-Encoded IpaH Ubiquitin Ligases Indicate Non-Human Enteroinvasive Escherichia.” Scientific Reports, vol. 12, 6868, Springer Nature, 2022, doi:10.1038/s41598-022-10827-3.","ista":"Dranenko N, Tutukina M, Gelfand M, Kondrashov F, Bochkareva O. 2022. Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia. Scientific Reports. 12, 6868.","ieee":"N. Dranenko, M. Tutukina, M. Gelfand, F. Kondrashov, and O. Bochkareva, “Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia,” Scientific Reports, vol. 12. Springer Nature, 2022.","ama":"Dranenko N, Tutukina M, Gelfand M, Kondrashov F, Bochkareva O. Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia. Scientific Reports. 2022;12. doi:10.1038/s41598-022-10827-3","apa":"Dranenko, N., Tutukina, M., Gelfand, M., Kondrashov, F., & Bochkareva, O. (2022). Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-022-10827-3","short":"N. Dranenko, M. Tutukina, M. Gelfand, F. Kondrashov, O. Bochkareva, Scientific Reports 12 (2022).","chicago":"Dranenko, NO, MN Tutukina, MS Gelfand, Fyodor Kondrashov, and Olga Bochkareva. “Chromosome-Encoded IpaH Ubiquitin Ligases Indicate Non-Human Enteroinvasive Escherichia.” Scientific Reports. Springer Nature, 2022. https://doi.org/10.1038/s41598-022-10827-3."},"isi":1,"type":"journal_article","intvolume":" 12","publisher":"Springer Nature","date_published":"2022-04-27T00:00:00Z","status":"public","ddc":["570"],"abstract":[{"lang":"eng","text":"Until recently, Shigella and enteroinvasive Escherichia coli were thought to be primate-restricted pathogens. The base of their pathogenicity is the type 3 secretion system (T3SS) encoded by the pINV virulence plasmid, which facilitates host cell invasion and subsequent proliferation. A large family of T3SS effectors, E3 ubiquitin-ligases encoded by the ipaH genes, have a key role in the Shigella pathogenicity through the modulation of cellular ubiquitination that degrades host proteins. However, recent genomic studies identified ipaH genes in the genomes of Escherichia marmotae, a potential marmot pathogen, and an E. coli extracted from fecal samples of bovine calves, suggesting that non-human hosts may also be infected by these strains, potentially pathogenic to humans. We performed a comparative genomic study of the functional repertoires in the ipaH gene family in Shigella and enteroinvasive Escherichia from human and predicted non-human hosts. We found that fewer than half of Shigella genomes had a complete set of ipaH genes, with frequent gene losses and duplications that were not consistent with the species tree and nomenclature. Non-human host IpaH proteins had a diverse set of substrate-binding domains and, in contrast to the Shigella proteins, two variants of the NEL C-terminal domain. Inconsistencies between strains phylogeny and composition of effectors indicate horizontal gene transfer between E. coli adapted to different hosts. These results provide a framework for understanding of ipaH-mediated host-pathogens interactions and suggest a need for a genomic study of fecal samples from diseased animals."}],"publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s41598-022-10827-3","pmid":1,"month":"04","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"language":[{"iso":"eng"}],"ec_funded":1,"oa_version":"Published Version","date_updated":"2026-04-15T08:51:09Z","corr_author":"1","file":[{"creator":"dernst","access_level":"open_access","date_updated":"2022-05-02T09:05:20Z","content_type":"application/pdf","relation":"main_file","checksum":"12601b8a5c6b83bb618f92bcb963ecc9","date_created":"2022-05-02T09:05:20Z","file_id":"11349","success":1,"file_size":3564155,"file_name":"2022_ScientificReports_Dranenko.pdf"}],"day":"27"},{"related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1007/s11538-022-01118-z"}]},"title":"Relation between the number of peaks and the number of reciprocal sign epistatic interactions","external_id":{"pmid":["35713756"],"isi":["000812509800001"]},"article_type":"original","volume":84,"year":"2022","publication":"Bulletin of Mathematical Biology","project":[{"name":"Characterizing the fitness landscape on population and global scales","_id":"26580278-B435-11E9-9278-68D0E5697425","grant_number":"771209","call_identifier":"H2020"},{"name":"Evolutionary analysis of gene regulation","_id":"34e076d6-11ca-11ed-8bc3-aec76c41a181","grant_number":"I05127"}],"acknowledgement":"We are grateful to Herbert Edelsbrunner and Jeferson Zapata for helpful discussions. Open access funding provided by Austrian Science Fund (FWF). Partially supported by the ERC Consolidator (771209–CharFL) and the FWF Austrian Science Fund (I5127-B) grants to FAK.","date_created":"2022-06-17T16:16:15Z","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0092-8240"],"eissn":["1522-9602"]},"department":[{"_id":"GradSch"},{"_id":"NiBa"},{"_id":"JaMa"}],"has_accepted_license":"1","article_number":"74","scopus_import":"1","quality_controlled":"1","citation":{"chicago":"Saona Urmeneta, Raimundo J, Fyodor Kondrashov, and Kseniia Khudiakova. “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic Interactions.” Bulletin of Mathematical Biology. Springer Nature, 2022. https://doi.org/10.1007/s11538-022-01029-z.","short":"R.J. Saona Urmeneta, F. Kondrashov, K. Khudiakova, Bulletin of Mathematical Biology 84 (2022).","apa":"Saona Urmeneta, R. J., Kondrashov, F., & Khudiakova, K. (2022). Relation between the number of peaks and the number of reciprocal sign epistatic interactions. Bulletin of Mathematical Biology. Springer Nature. https://doi.org/10.1007/s11538-022-01029-z","ama":"Saona Urmeneta RJ, Kondrashov F, Khudiakova K. Relation between the number of peaks and the number of reciprocal sign epistatic interactions. Bulletin of Mathematical Biology. 2022;84(8). doi:10.1007/s11538-022-01029-z","ista":"Saona Urmeneta RJ, Kondrashov F, Khudiakova K. 2022. Relation between the number of peaks and the number of reciprocal sign epistatic interactions. Bulletin of Mathematical Biology. 84(8), 74.","mla":"Saona Urmeneta, Raimundo J., et al. “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic Interactions.” Bulletin of Mathematical Biology, vol. 84, no. 8, 74, Springer Nature, 2022, doi:10.1007/s11538-022-01029-z.","ieee":"R. J. Saona Urmeneta, F. Kondrashov, and K. Khudiakova, “Relation between the number of peaks and the number of reciprocal sign epistatic interactions,” Bulletin of Mathematical Biology, vol. 84, no. 8. Springer Nature, 2022."},"keyword":["Computational Theory and Mathematics","General Agricultural and Biological Sciences","Pharmacology","General Environmental Science","General Biochemistry","Genetics and Molecular Biology","General Mathematics","Immunology","General Neuroscience"],"author":[{"full_name":"Saona Urmeneta, Raimundo J","orcid":"0000-0001-5103-038X","id":"BD1DF4C4-D767-11E9-B658-BC13E6697425","last_name":"Saona Urmeneta","first_name":"Raimundo J"},{"first_name":"Fyodor","orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","last_name":"Kondrashov","full_name":"Kondrashov, Fyodor"},{"full_name":"Khudiakova, Kseniia","orcid":"0000-0002-6246-1465","id":"4E6DC800-AE37-11E9-AC72-31CAE5697425","last_name":"Khudiakova","first_name":"Kseniia"}],"file_date_updated":"2022-06-20T07:51:32Z","_id":"11447","intvolume":" 84","publisher":"Springer Nature","type":"journal_article","isi":1,"publication_status":"published","abstract":[{"lang":"eng","text":"Empirical essays of fitness landscapes suggest that they may be rugged, that is having multiple fitness peaks. Such fitness landscapes, those that have multiple peaks, necessarily have special local structures, called reciprocal sign epistasis (Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the quantitative relationship between the number of fitness peaks and the number of reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis is a necessary but not sufficient condition for the existence of multiple peaks. Applying discrete Morse theory, which to our knowledge has never been used in this context, we extend this result by giving the minimal number of reciprocal sign epistatic interactions required to create a given number of peaks."}],"ddc":["510","570"],"date_published":"2022-06-17T00:00:00Z","status":"public","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"06","pmid":1,"doi":"10.1007/s11538-022-01029-z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"8","date_updated":"2026-04-15T08:51:10Z","oa_version":"Published Version","oa":1,"ec_funded":1,"language":[{"iso":"eng"}],"day":"17","corr_author":"1","file":[{"checksum":"05a1fe7d10914a00c2bca9b447993a65","date_created":"2022-06-20T07:51:32Z","file_id":"11455","success":1,"file_size":463025,"file_name":"2022_BulletinMathBiology_Saona.pdf","creator":"dernst","access_level":"open_access","date_updated":"2022-06-20T07:51:32Z","content_type":"application/pdf","relation":"main_file"}]},{"abstract":[{"text":"The scope of this thesis is to study quantum systems exhibiting a continuous symmetry that\r\nis broken on the level of the corresponding effective theory. In particular we are going to\r\ninvestigate translation-invariant Bose gases in the mean field limit, effectively described by\r\nthe Hartree functional, and the Fröhlich Polaron in the regime of strong coupling, effectively\r\ndescribed by the Pekar functional. The latter is a model describing the interaction between a\r\ncharged particle and the optical modes of a polar crystal. Regarding the former, we assume in\r\naddition that the particles in the gas are unconfined, and typically we will consider particles\r\nthat are subject to an attractive interaction. In both cases the ground state energy of the\r\nHamiltonian is not a proper eigenvalue due to the underlying translation-invariance, while on\r\nthe contrary there exists a whole invariant orbit of minimizers for the corresponding effective\r\nfunctionals. Both, the absence of proper eigenstates and the broken symmetry of the effective\r\ntheory, make the study significantly more involved and it is the content of this thesis to\r\ndevelop a frameworks which allows for a systematic way to circumvent these issues.\r\nIt is a well-established result that the ground state energy of Bose gases in the mean field limit,\r\nas well as the ground state energy of the Fröhlich Polaron in the regime of strong coupling, is\r\nto leading order given by the minimal energy of the corresponding effective theory. As part\r\nof this thesis we identify the sub-leading term in the expansion of the ground state energy,\r\nwhich can be interpreted as the quantum correction to the classical energy, since the effective\r\ntheories under consideration can be seen as classical counterparts.\r\nWe are further going to establish an asymptotic expression for the energy-momentum relation\r\nof the Fröhlich Polaron in the strong coupling limit. In the regime of suitably small momenta,\r\nthis asymptotic expression agrees with the energy-momentum relation of a free particle having\r\nan effectively increased mass, and we find that this effectively increased mass agrees with the\r\nconjectured value in the physics literature.\r\nIn addition we will discuss two unrelated papers written by the author during his stay at ISTA\r\nin the appendix. The first one concerns the realization of anyons, which are quasi-particles\r\nacquiring a non-trivial phase under the exchange of two particles, as molecular impurities.\r\nThe second one provides a classification of those vector fields defined on a given manifold\r\nthat can be written as the gradient of a given functional with respect to a suitable metric,\r\nprovided that some mild smoothness assumptions hold. This classification is subsequently\r\nused to identify those quantum Markov semigroups that can be written as a gradient flow of\r\nthe relative entropy.\r\n","lang":"eng"}],"publication_status":"published","ddc":["500"],"date_published":"2022-12-15T00:00:00Z","status":"public","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"month":"12","supervisor":[{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","first_name":"Robert","full_name":"Seiringer, Robert"}],"doi":"10.15479/at:ista:12390","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-16T08:20:52Z","oa_version":"Published Version","alternative_title":["ISTA Thesis"],"oa":1,"ec_funded":1,"language":[{"iso":"eng"}],"day":"15","corr_author":"1","file":[{"success":1,"file_size":3095225,"file_name":"Brooks_Thesis.pdf","checksum":"b31460e937f33b557abb40ebef02b567","date_created":"2023-01-26T10:02:34Z","file_id":"12391","content_type":"application/pdf","relation":"main_file","creator":"cchlebak","access_level":"open_access","date_updated":"2023-01-26T10:02:34Z"},{"date_updated":"2023-01-26T10:02:42Z","creator":"cchlebak","access_level":"closed","content_type":"application/octet-stream","relation":"source_file","date_created":"2023-01-26T10:02:42Z","file_id":"12392","checksum":"9751869fa5e7981588ad4228f4fd4bd6","file_name":"Brooks_Thesis.tex","file_size":809842}],"page":"196","OA_place":"publisher","degree_awarded":"PhD","related_material":{"record":[{"relation":"part_of_dissertation","id":"9005","status":"public"}]},"title":"Translation-invariant quantum systems with effectively broken symmetry","year":"2022","project":[{"grant_number":"694227","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems"}],"date_created":"2023-01-26T10:00:42Z","article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"department":[{"_id":"GradSch"},{"_id":"RoSe"}],"has_accepted_license":"1","citation":{"short":"M. Brooks, Translation-Invariant Quantum Systems with Effectively Broken Symmetry, Institute of Science and Technology Austria, 2022.","apa":"Brooks, M. (2022). Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12390","chicago":"Brooks, Morris. “Translation-Invariant Quantum Systems with Effectively Broken Symmetry.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12390.","ista":"Brooks M. 2022. Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria.","mla":"Brooks, Morris. Translation-Invariant Quantum Systems with Effectively Broken Symmetry. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12390.","ieee":"M. Brooks, “Translation-invariant quantum systems with effectively broken symmetry,” Institute of Science and Technology Austria, 2022.","ama":"Brooks M. Translation-invariant quantum systems with effectively broken symmetry. 2022. doi:10.15479/at:ista:12390"},"author":[{"orcid":"0000-0002-6249-0928","id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","last_name":"Brooks","first_name":"Morris","full_name":"Brooks, Morris"}],"file_date_updated":"2023-01-26T10:02:42Z","_id":"12390","publisher":"Institute of Science and Technology Austria","type":"dissertation"}]