[{"language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"oa_version":"Published Version","date_updated":"2025-04-14T09:44:14Z","issue":"4","file":[{"checksum":"eac5a51c24c8989ae7cf9ae32ec3bc95","date_created":"2022-04-08T06:05:39Z","file_id":"11131","success":1,"file_name":"2021_NeuralComputation_Zenke.pdf","file_size":1611614,"creator":"dernst","access_level":"open_access","date_updated":"2022-04-08T06:05:39Z","content_type":"application/pdf","relation":"main_file"}],"corr_author":"1","license":"https://creativecommons.org/licenses/by/4.0/","day":"01","status":"public","date_published":"2021-03-01T00:00:00Z","ddc":["000","570"],"publication_status":"published","abstract":[{"lang":"eng","text":"Brains process information in spiking neural networks. Their intricate connections shape the diverse functions these networks perform. In comparison, the functional capabilities of models of spiking networks are still rudimentary. This shortcoming is mainly due to the lack of insight and practical algorithms to construct the necessary connectivity. Any such algorithm typically attempts to build networks by iteratively reducing the error compared to a desired output. But assigning credit to hidden units in multi-layered spiking networks has remained challenging due to the non-differentiable nonlinearity of spikes. To avoid this issue, one can employ surrogate gradients to discover the required connectivity in spiking network models. However, the choice of a surrogate is not unique, raising the question of how its implementation influences the effectiveness of the method. Here, we use numerical simulations to systematically study how essential design parameters of surrogate gradients impact learning performance on a range of classification problems. We show that surrogate gradient learning is robust to different shapes of underlying surrogate derivatives, but the choice of the derivative’s scale can substantially affect learning performance. When we combine surrogate gradients with a suitable activity regularization technique, robust information processing can be achieved in spiking networks even at the sparse activity limit. Our study provides a systematic account of the remarkable robustness of surrogate gradient learning and serves as a practical guide to model functional spiking neural networks."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1162/neco_a_01367","pmid":1,"month":"03","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file_date_updated":"2022-04-08T06:05:39Z","_id":"8253","author":[{"last_name":"Zenke","orcid":"0000-0003-1883-644X","first_name":"Friedemann","full_name":"Zenke, Friedemann"},{"first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P"}],"citation":{"apa":"Zenke, F., &#38; Vogels, T. P. (2021). The remarkable robustness of surrogate gradient learning for instilling complex function in spiking neural networks. <i>Neural Computation</i>. MIT Press. <a href=\"https://doi.org/10.1162/neco_a_01367\">https://doi.org/10.1162/neco_a_01367</a>","short":"F. Zenke, T.P. Vogels, Neural Computation 33 (2021) 899–925.","chicago":"Zenke, Friedemann, and Tim P Vogels. “The Remarkable Robustness of Surrogate Gradient Learning for Instilling Complex Function in Spiking Neural Networks.” <i>Neural Computation</i>. MIT Press, 2021. <a href=\"https://doi.org/10.1162/neco_a_01367\">https://doi.org/10.1162/neco_a_01367</a>.","mla":"Zenke, Friedemann, and Tim P. Vogels. “The Remarkable Robustness of Surrogate Gradient Learning for Instilling Complex Function in Spiking Neural Networks.” <i>Neural Computation</i>, vol. 33, no. 4, MIT Press, 2021, pp. 899–925, doi:<a href=\"https://doi.org/10.1162/neco_a_01367\">10.1162/neco_a_01367</a>.","ieee":"F. Zenke and T. P. Vogels, “The remarkable robustness of surrogate gradient learning for instilling complex function in spiking neural networks,” <i>Neural Computation</i>, vol. 33, no. 4. MIT Press, pp. 899–925, 2021.","ista":"Zenke F, Vogels TP. 2021. The remarkable robustness of surrogate gradient learning for instilling complex function in spiking neural networks. Neural Computation. 33(4), 899–925.","ama":"Zenke F, Vogels TP. The remarkable robustness of surrogate gradient learning for instilling complex function in spiking neural networks. <i>Neural Computation</i>. 2021;33(4):899-925. doi:<a href=\"https://doi.org/10.1162/neco_a_01367\">10.1162/neco_a_01367</a>"},"quality_controlled":"1","scopus_import":"1","has_accepted_license":"1","isi":1,"type":"journal_article","publisher":"MIT Press","intvolume":"        33","project":[{"call_identifier":"H2020","grant_number":"819603","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning."},{"name":"What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent neuronal networks.","_id":"c084a126-5a5b-11eb-8a69-d75314a70a87","grant_number":"214316/Z/18/Z"}],"publication":"Neural Computation","year":"2021","volume":33,"external_id":{"isi":["000663433900003"],"pmid":["33513328"]},"article_type":"original","title":"The remarkable robustness of surrogate gradient learning for instilling complex function in spiking neural networks","page":"899-925","department":[{"_id":"TiVo"}],"publication_identifier":{"eissn":["1530-888X"],"issn":["0899-7667"]},"article_processing_charge":"No","date_created":"2020-08-12T12:08:24Z","acknowledgement":"F.Z. was supported by the Wellcome Trust (110124/Z/15/Z) and the Novartis Research Foundation. T.P.V. was supported by a Wellcome Trust Sir Henry Dale Research fellowship (WT100000), a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z), and an ERC Consolidator Grant SYNAPSEEK."},{"author":[{"last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2548-617X","first_name":"Arseniy","full_name":"Akopyan, Arseniy"},{"full_name":"Bobenko, Alexander I.","first_name":"Alexander I.","last_name":"Bobenko"},{"full_name":"Schief, Wolfgang K.","first_name":"Wolfgang K.","last_name":"Schief"},{"full_name":"Techter, Jan","first_name":"Jan","last_name":"Techter"}],"_id":"8338","citation":{"ama":"Akopyan A, Bobenko AI, Schief WK, Techter J. On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs. <i>Discrete and Computational Geometry</i>. 2021;66:938-976. doi:<a href=\"https://doi.org/10.1007/s00454-020-00240-w\">10.1007/s00454-020-00240-w</a>","mla":"Akopyan, Arseniy, et al. “On Mutually Diagonal Nets on (Confocal) Quadrics and 3-Dimensional Webs.” <i>Discrete and Computational Geometry</i>, vol. 66, Springer Nature, 2021, pp. 938–76, doi:<a href=\"https://doi.org/10.1007/s00454-020-00240-w\">10.1007/s00454-020-00240-w</a>.","ieee":"A. Akopyan, A. I. Bobenko, W. K. Schief, and J. Techter, “On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs,” <i>Discrete and Computational Geometry</i>, vol. 66. Springer Nature, pp. 938–976, 2021.","ista":"Akopyan A, Bobenko AI, Schief WK, Techter J. 2021. On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs. Discrete and Computational Geometry. 66, 938–976.","chicago":"Akopyan, Arseniy, Alexander I. Bobenko, Wolfgang K. Schief, and Jan Techter. “On Mutually Diagonal Nets on (Confocal) Quadrics and 3-Dimensional Webs.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00454-020-00240-w\">https://doi.org/10.1007/s00454-020-00240-w</a>.","short":"A. Akopyan, A.I. Bobenko, W.K. Schief, J. Techter, Discrete and Computational Geometry 66 (2021) 938–976.","apa":"Akopyan, A., Bobenko, A. I., Schief, W. K., &#38; Techter, J. (2021). On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-020-00240-w\">https://doi.org/10.1007/s00454-020-00240-w</a>"},"quality_controlled":"1","scopus_import":"1","type":"journal_article","isi":1,"publisher":"Springer Nature","intvolume":"        66","year":"2021","publication":"Discrete and Computational Geometry","project":[{"name":"Alpha Shape Theory Extended","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","grant_number":"788183","call_identifier":"H2020"}],"external_id":{"isi":["000564488500002"],"arxiv":["1908.00856"]},"title":"On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs","article_type":"original","volume":66,"page":"938-976","department":[{"_id":"HeEd"}],"publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"acknowledgement":"This research was supported by the DFG Collaborative Research Center TRR 109 “Discretization in Geometry and Dynamics”. W.K.S. was also supported by the Australian Research Council (DP1401000851). A.V.A. was also supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 78818 Alpha).","date_created":"2020-09-06T22:01:13Z","article_processing_charge":"No","language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"arxiv":1,"oa_version":"Preprint","date_updated":"2025-04-14T07:48:36Z","day":"01","status":"public","date_published":"2021-10-01T00:00:00Z","abstract":[{"lang":"eng","text":"Canonical parametrisations of classical confocal coordinate systems are introduced and exploited to construct non-planar analogues of incircular (IC) nets on individual quadrics and systems of confocal quadrics. Intimate connections with classical deformations of quadrics that are isometric along asymptotic lines and circular cross-sections of quadrics are revealed. The existence of octahedral webs of surfaces of Blaschke type generated by asymptotic and characteristic lines that are diagonally related to lines of curvature is proved theoretically and established constructively. Appropriate samplings (grids) of these webs lead to three-dimensional extensions of non-planar IC nets. Three-dimensional octahedral grids composed of planes and spatially extending (checkerboard) IC-nets are shown to arise in connection with systems of confocal quadrics in Minkowski space. In this context, the Laguerre geometric notion of conical octahedral grids of planes is introduced. The latter generalise the octahedral grids derived from systems of confocal quadrics in Minkowski space. An explicit construction of conical octahedral grids is presented. The results are accompanied by various illustrations which are based on the explicit formulae provided by the theory."}],"publication_status":"published","doi":"10.1007/s00454-020-00240-w","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://arxiv.org/abs/1908.00856","open_access":"1"}],"month":"10"},{"month":"01","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2002.11678"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1016/j.laa.2020.09.007","publication_status":"published","abstract":[{"lang":"eng","text":"It is well known that special Kubo-Ando operator means admit divergence center interpretations, moreover, they are also mean squared error estimators for certain metrics on positive definite operators. In this paper we give a divergence center interpretation for every symmetric Kubo-Ando mean. This characterization of the symmetric means naturally leads to a definition of weighted and multivariate versions of a large class of symmetric Kubo-Ando means. We study elementary properties of these weighted multivariate means, and note in particular that in the special case of the geometric mean we recover the weighted A#H-mean introduced by Kim, Lawson, and Lim."}],"date_published":"2021-01-15T00:00:00Z","status":"public","day":"15","oa_version":"Preprint","date_updated":"2025-04-14T07:50:40Z","arxiv":1,"ec_funded":1,"oa":1,"language":[{"iso":"eng"}],"article_processing_charge":"No","date_created":"2020-09-11T08:35:50Z","acknowledgement":"The authors are grateful to Milán Mosonyi for fruitful discussions on the topic, and to the anonymous referee for his/her comments and suggestions.\r\nJ. Pitrik was supported by the Hungarian Academy of Sciences Lendület-Momentum Grant for Quantum Information Theory, No. 96 141, and by Hungarian National Research, Development and Innovation Office (NKFIH) via grants no. K119442, no. K124152, and no. KH129601. D. Virosztek was supported by the ISTFELLOW program of the Institute of Science and Technology Austria (project code IC1027FELL01), by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 846294, and partially supported by the Hungarian National Research, Development and Innovation Office (NKFIH) via grants no. K124152, and no. KH129601.","publication_identifier":{"issn":["0024-3795"]},"department":[{"_id":"LaEr"}],"page":"203-217","volume":609,"article_type":"original","external_id":{"isi":["000581730500011"],"arxiv":["2002.11678"]},"title":"A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means","project":[{"call_identifier":"H2020","grant_number":"846294","_id":"26A455A6-B435-11E9-9278-68D0E5697425","name":"Geometric study of Wasserstein spaces and free probability"},{"call_identifier":"FP7","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"publication":"Linear Algebra and its Applications","year":"2021","intvolume":"       609","publisher":"Elsevier","isi":1,"type":"journal_article","scopus_import":"1","quality_controlled":"1","keyword":["Kubo-Ando mean","weighted multivariate mean","barycenter"],"citation":{"short":"J. Pitrik, D. Virosztek, Linear Algebra and Its Applications 609 (2021) 203–217.","apa":"Pitrik, J., &#38; Virosztek, D. (2021). A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. <i>Linear Algebra and Its Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">https://doi.org/10.1016/j.laa.2020.09.007</a>","chicago":"Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator Means.” <i>Linear Algebra and Its Applications</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">https://doi.org/10.1016/j.laa.2020.09.007</a>.","mla":"Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator Means.” <i>Linear Algebra and Its Applications</i>, vol. 609, Elsevier, 2021, pp. 203–17, doi:<a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">10.1016/j.laa.2020.09.007</a>.","ieee":"J. Pitrik and D. Virosztek, “A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means,” <i>Linear Algebra and its Applications</i>, vol. 609. Elsevier, pp. 203–217, 2021.","ista":"Pitrik J, Virosztek D. 2021. A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. Linear Algebra and its Applications. 609, 203–217.","ama":"Pitrik J, Virosztek D. A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. <i>Linear Algebra and its Applications</i>. 2021;609:203-217. doi:<a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">10.1016/j.laa.2020.09.007</a>"},"_id":"8373","author":[{"first_name":"József","last_name":"Pitrik","full_name":"Pitrik, József"},{"full_name":"Virosztek, Daniel","first_name":"Daniel","orcid":"0000-0003-1109-5511","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","last_name":"Virosztek"}]},{"department":[{"_id":"MaRo"}],"acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the cohort studies, and the Ecole Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity with their time and the kindness of their support. P.M.V. acknowledges funding from the Australian National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072). L.R. acknowledges funding from the Kjell & Märta Beijer Foundation (Stockholm, Sweden). We also would like to acknowledge Simone Rubinacci, Oliver Delanau, Alexander Terenin, Eleonora Porcu, and Mike Goddard for their useful comments and suggestions.","date_created":"2020-09-17T10:52:38Z","article_processing_charge":"No","publication_identifier":{"eissn":["2041-1723"]},"article_type":"original","external_id":{"isi":["000724450600023"],"pmid":["34848700"]},"title":"Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits","volume":12,"year":"2021","publication":"Nature Communications","related_material":{"record":[{"relation":"research_data","id":"13063","status":"public"}]},"type":"journal_article","isi":1,"intvolume":"        12","publisher":"Springer Nature","author":[{"full_name":"Patxot, Marion","last_name":"Patxot","first_name":"Marion"},{"last_name":"Trejo Banos","first_name":"Daniel","full_name":"Trejo Banos, Daniel"},{"full_name":"Kousathanas, Athanasios","first_name":"Athanasios","last_name":"Kousathanas"},{"last_name":"Orliac","first_name":"Etienne J","full_name":"Orliac, Etienne J"},{"full_name":"Ojavee, Sven E","last_name":"Ojavee","first_name":"Sven E"},{"full_name":"Moser, Gerhard","first_name":"Gerhard","last_name":"Moser"},{"full_name":"Sidorenko, Julia","first_name":"Julia","last_name":"Sidorenko"},{"full_name":"Kutalik, Zoltan","last_name":"Kutalik","first_name":"Zoltan"},{"full_name":"Magi, Reedik","first_name":"Reedik","last_name":"Magi"},{"full_name":"Visscher, Peter M","last_name":"Visscher","first_name":"Peter M"},{"full_name":"Ronnegard, Lars","last_name":"Ronnegard","first_name":"Lars"},{"full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"}],"_id":"8429","file_date_updated":"2021-12-06T07:47:11Z","has_accepted_license":"1","scopus_import":"1","quality_controlled":"1","article_number":"6972","citation":{"chicago":"Patxot, Marion, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J Orliac, Sven E Ojavee, Gerhard Moser, Julia Sidorenko, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>.","apa":"Patxot, M., Trejo Banos, D., Kousathanas, A., Orliac, E. J., Ojavee, S. E., Moser, G., … Robinson, M. R. (2021). Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>","short":"M. Patxot, D. Trejo Banos, A. Kousathanas, E.J. Orliac, S.E. Ojavee, G. Moser, J. Sidorenko, Z. Kutalik, R. Magi, P.M. Visscher, L. Ronnegard, M.R. Robinson, Nature Communications 12 (2021).","ama":"Patxot M, Trejo Banos D, Kousathanas A, et al. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>","mla":"Patxot, Marion, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>, vol. 12, no. 1, 6972, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>.","ista":"Patxot M, Trejo Banos D, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Sidorenko J, Kutalik Z, Magi R, Visscher PM, Ronnegard L, Robinson MR. 2021. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. Nature Communications. 12(1), 6972.","ieee":"M. Patxot <i>et al.</i>, “Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021."},"doi":"10.1038/s41467-021-27258-9","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"11","date_published":"2021-11-30T00:00:00Z","status":"public","abstract":[{"lang":"eng","text":"We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only ≤10% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each chromosome are associated with each trait, with over 3,100 independent exonic and intronic regions and over 5,400 independent regulatory regions having ≥95% probability of contributing ≥0.001% to the genetic variance of these four traits. Our open-source software (GMRM) provides a scalable alternative to current approaches for biobank data."}],"publication_status":"published","ddc":["610"],"file":[{"relation":"main_file","content_type":"application/pdf","date_updated":"2021-12-06T07:47:11Z","access_level":"open_access","creator":"cchlebak","file_name":"2021_NatComm_Paxtot.pdf","file_size":6519771,"success":1,"file_id":"10419","date_created":"2021-12-06T07:47:11Z","checksum":"384681be17aff902c149a48f52d13d4f"}],"day":"30","language":[{"iso":"eng"}],"oa":1,"issue":"1","oa_version":"Published Version","date_updated":"2025-06-12T06:54:52Z"},{"abstract":[{"text":"The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, yet this hypothesis has not been causally tested in vivo in the mammalian brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex. Here we show that sparse but not global knockout of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular layer and overelaboration in the superficial molecular layer. Developmental, overexpression, structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner. A generative model of dendritic growth based on competitive synaptogenesis largely recapitulates GluD2 sparse and global knockout phenotypes. Our results support the synaptotrophic hypothesis at initial stages of dendrite development, suggest a second mode in which cumulative synapse formation inhibits further dendrite growth, and highlight the importance of competition in dendrite morphogenesis.","lang":"eng"}],"publication_status":"published","date_published":"2021-02-17T00:00:00Z","status":"public","month":"02","main_file_link":[{"url":"https://doi.org/10.1101/2020.06.14.151258","open_access":"1"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","pmid":1,"doi":"10.1016/j.neuron.2020.11.028","oa_version":"Preprint","date_updated":"2025-09-10T09:58:28Z","issue":"4","oa":1,"ec_funded":1,"language":[{"iso":"eng"}],"day":"17","page":"P629-644.E8","volume":109,"article_type":"original","external_id":{"isi":["000632657400006"],"pmid":["33352118"]},"title":"GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells","publication":"Neuron","project":[{"grant_number":"725780","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","_id":"260018B0-B435-11E9-9278-68D0E5697425"}],"year":"2021","article_processing_charge":"No","date_created":"2020-09-21T11:59:47Z","acknowledgement":"We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I. Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W. Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin, D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript, and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T. was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538) to L.L.; the European Research Council (ERC) under the European Union's Horizon 2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI investigator.","publication_identifier":{"eissn":["1097-4199"]},"department":[{"_id":"SiHi"}],"quality_controlled":"1","scopus_import":"1","citation":{"ama":"Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>. 2021;109(4):P629-644.E8. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">10.1016/j.neuron.2020.11.028</a>","ista":"Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X, Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron. 109(4), P629–644.E8.","mla":"Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>, vol. 109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">10.1016/j.neuron.2020.11.028</a>.","ieee":"Y. H. Takeo <i>et al.</i>, “GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells,” <i>Neuron</i>, vol. 109, no. 4. Elsevier, p. P629–644.E8, 2021.","chicago":"Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl, Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">https://doi.org/10.1016/j.neuron.2020.11.028</a>.","apa":"Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke, T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">https://doi.org/10.1016/j.neuron.2020.11.028</a>","short":"Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X. Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021) P629–644.E8."},"_id":"8544","author":[{"last_name":"Takeo","first_name":"Yukari H.","full_name":"Takeo, Yukari H."},{"full_name":"Shuster, S. Andrew","last_name":"Shuster","first_name":"S. Andrew"},{"last_name":"Jiang","first_name":"Linnie","full_name":"Jiang, Linnie"},{"full_name":"Hu, Miley","first_name":"Miley","last_name":"Hu"},{"full_name":"Luginbuhl, David J.","last_name":"Luginbuhl","first_name":"David J."},{"full_name":"Rülicke, Thomas","first_name":"Thomas","last_name":"Rülicke"},{"full_name":"Contreras, Ximena","first_name":"Ximena","last_name":"Contreras","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","first_name":"Simon","full_name":"Hippenmeyer, Simon"},{"first_name":"Mark J.","last_name":"Wagner","full_name":"Wagner, Mark J."},{"full_name":"Ganguli, Surya","first_name":"Surya","last_name":"Ganguli"},{"full_name":"Luo, Liqun","first_name":"Liqun","last_name":"Luo"}],"intvolume":"       109","publisher":"Elsevier","isi":1,"type":"journal_article"},{"date_published":"2021-01-01T00:00:00Z","status":"public","ddc":["580"],"publication_status":"published","abstract":[{"text":"Cell and tissue polarization is fundamental for plant growth and morphogenesis. The polar, cellular localization of Arabidopsis PIN‐FORMED (PIN) proteins is crucial for their function in directional auxin transport. The clustering of PIN polar cargoes within the plasma membrane has been proposed to be important for the maintenance of their polar distribution. However, the more detailed features of PIN clusters and the cellular requirements of cargo clustering remain unclear.\r\nHere, we characterized PIN clusters in detail by means of multiple advanced microscopy and quantification methods, such as 3D quantitative imaging or freeze‐fracture replica labeling. The size and aggregation types of PIN clusters were determined by electron microscopy at the nanometer level at different polar domains and at different developmental stages, revealing a strong preference for clustering at the polar domains.\r\nPharmacological and genetic studies revealed that PIN clusters depend on phosphoinositol pathways, cytoskeletal structures and specific cell‐wall components as well as connections between the cell wall and the plasma membrane.\r\nThis study identifies the role of different cellular processes and structures in polar cargo clustering and provides initial mechanistic insight into the maintenance of polarity in plants and other systems.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1111/nph.16887","pmid":1,"month":"01","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"language":[{"iso":"eng"}],"ec_funded":1,"date_updated":"2025-06-12T06:32:24Z","oa_version":"Published Version","issue":"1","file":[{"content_type":"application/pdf","relation":"main_file","date_updated":"2021-02-04T09:44:17Z","creator":"dernst","access_level":"open_access","success":1,"file_size":4061962,"file_name":"2021_NewPhytologist_Li.pdf","date_created":"2021-02-04T09:44:17Z","file_id":"9084","checksum":"b45621607b4cab97eeb1605ab58e896e"}],"day":"01","volume":229,"title":"Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana","external_id":{"isi":["000570187900001"],"pmid":["32810889"]},"article_type":"original","publication":"New Phytologist","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","call_identifier":"H2020"},{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"year":"2021","page":"351-369","department":[{"_id":"JiFr"},{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"EvBe"}],"article_processing_charge":"Yes (via OA deal)","date_created":"2020-09-28T08:59:28Z","acknowledgement":"We thank Dr Ingo Heilmann (Martin‐Luther‐University Halle‐Wittenberg) for the XVE>>PIP5K1‐YFP line, Dr Brad Day (Michigan State University) for the ndr1‐1 mutant and the complementation lines, and Dr Patricia C. Zambryski (University of California, Berkeley) for the 35S::P30‐GFP line, the Bioimaging team (IST Austria) for assistance with imaging, group members for discussions, Martine De Cock for help in preparing the manuscript and Nataliia Gnyliukh for critical reading and revision of the manuscript. This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 742985) and Comisión Nacional de Investigación Científica y Tecnológica (Project CONICYT‐PAI 82130047). DvW received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007‐2013) under REA grant agreement no. 291734.","acknowledged_ssus":[{"_id":"Bio"}],"publication_identifier":{"eissn":["1469-8137"],"issn":["0028-646X"]},"_id":"8582","file_date_updated":"2021-02-04T09:44:17Z","author":[{"full_name":"Li, Hongjiang","first_name":"Hongjiang","last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5039-9660"},{"first_name":"Daniel","last_name":"von Wangenheim","id":"49E91952-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6862-1247","full_name":"von Wangenheim, Daniel"},{"id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","last_name":"Zhang","orcid":"0000-0001-7048-4627","first_name":"Xixi","full_name":"Zhang, Xixi"},{"full_name":"Tan, Shutang","first_name":"Shutang","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0471-8285"},{"orcid":"0000-0002-8821-8236","id":"39CD9926-F248-11E8-B48F-1D18A9856A87","last_name":"Darwish-Miranda","first_name":"Nasser","full_name":"Darwish-Miranda, Nasser"},{"full_name":"Naramoto, Satoshi","first_name":"Satoshi","last_name":"Naramoto"},{"first_name":"Krzysztof T","orcid":"0000-0001-7263-0560","last_name":"Wabnik","id":"4DE369A4-F248-11E8-B48F-1D18A9856A87","full_name":"Wabnik, Krzysztof T"},{"full_name":"de Rycke, Riet","last_name":"de Rycke","first_name":"Riet"},{"full_name":"Kaufmann, Walter","orcid":"0000-0001-9735-5315","last_name":"Kaufmann","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter"},{"last_name":"Gütl","id":"381929CE-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel J","full_name":"Gütl, Daniel J"},{"full_name":"Tejos, Ricardo","last_name":"Tejos","first_name":"Ricardo"},{"first_name":"Peter","id":"399876EC-F248-11E8-B48F-1D18A9856A87","last_name":"Grones","full_name":"Grones, Peter"},{"full_name":"Ke, Meiyu","first_name":"Meiyu","last_name":"Ke"},{"first_name":"Xu","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","last_name":"Chen","full_name":"Chen, Xu"},{"full_name":"Dettmer, Jan","first_name":"Jan","last_name":"Dettmer"},{"full_name":"Friml, Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří"}],"scopus_import":"1","quality_controlled":"1","has_accepted_license":"1","citation":{"ista":"Li H, von Wangenheim D, Zhang X, Tan S, Darwish-Miranda N, Naramoto S, Wabnik KT, de Rycke R, Kaufmann W, Gütl DJ, Tejos R, Grones P, Ke M, Chen X, Dettmer J, Friml J. 2021. Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. New Phytologist. 229(1), 351–369.","ieee":"H. Li <i>et al.</i>, “Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana,” <i>New Phytologist</i>, vol. 229, no. 1. Wiley, pp. 351–369, 2021.","mla":"Li, Hongjiang, et al. “Cellular Requirements for PIN Polar Cargo Clustering in Arabidopsis Thaliana.” <i>New Phytologist</i>, vol. 229, no. 1, Wiley, 2021, pp. 351–69, doi:<a href=\"https://doi.org/10.1111/nph.16887\">10.1111/nph.16887</a>.","ama":"Li H, von Wangenheim D, Zhang X, et al. Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. <i>New Phytologist</i>. 2021;229(1):351-369. doi:<a href=\"https://doi.org/10.1111/nph.16887\">10.1111/nph.16887</a>","apa":"Li, H., von Wangenheim, D., Zhang, X., Tan, S., Darwish-Miranda, N., Naramoto, S., … Friml, J. (2021). Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16887\">https://doi.org/10.1111/nph.16887</a>","short":"H. Li, D. von Wangenheim, X. Zhang, S. Tan, N. Darwish-Miranda, S. Naramoto, K.T. Wabnik, R. de Rycke, W. Kaufmann, D.J. Gütl, R. Tejos, P. Grones, M. Ke, X. Chen, J. Dettmer, J. Friml, New Phytologist 229 (2021) 351–369.","chicago":"Li, Hongjiang, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda, Satoshi Naramoto, Krzysztof T Wabnik, et al. “Cellular Requirements for PIN Polar Cargo Clustering in Arabidopsis Thaliana.” <i>New Phytologist</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/nph.16887\">https://doi.org/10.1111/nph.16887</a>."},"isi":1,"type":"journal_article","intvolume":"       229","publisher":"Wiley"},{"day":"01","file":[{"file_name":"2021_CommPureApplMath_Frank.pdf","file_size":334987,"success":1,"checksum":"5f665ffa6e6dd958aec5c3040cbcfa84","file_id":"9236","date_created":"2021-03-11T10:03:30Z","relation":"main_file","content_type":"application/pdf","access_level":"open_access","creator":"dernst","date_updated":"2021-03-11T10:03:30Z"}],"issue":"3","date_updated":"2025-07-10T11:57:12Z","oa_version":"Published Version","language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"03","doi":"10.1002/cpa.21944","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","abstract":[{"text":"We consider the Fröhlich polaron model in the strong coupling limit. It is well‐known that to leading order the ground state energy is given by the (classical) Pekar energy. In this work, we establish the subleading correction, describing quantum fluctuation about the classical limit. Our proof applies to a model of a confined polaron, where both the electron and the polarization field are restricted to a set of finite volume, with linear size determined by the natural length scale of the Pekar problem.","lang":"eng"}],"ddc":["510"],"date_published":"2021-03-01T00:00:00Z","status":"public","intvolume":"        74","publisher":"Wiley","type":"journal_article","isi":1,"has_accepted_license":"1","quality_controlled":"1","scopus_import":"1","citation":{"chicago":"Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics of a Strongly Coupled Polaron.” <i>Communications on Pure and Applied Mathematics</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/cpa.21944\">https://doi.org/10.1002/cpa.21944</a>.","short":"R. Frank, R. Seiringer, Communications on Pure and Applied Mathematics 74 (2021) 544–588.","apa":"Frank, R., &#38; Seiringer, R. (2021). Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. <i>Communications on Pure and Applied Mathematics</i>. Wiley. <a href=\"https://doi.org/10.1002/cpa.21944\">https://doi.org/10.1002/cpa.21944</a>","ama":"Frank R, Seiringer R. Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. <i>Communications on Pure and Applied Mathematics</i>. 2021;74(3):544-588. doi:<a href=\"https://doi.org/10.1002/cpa.21944\">10.1002/cpa.21944</a>","mla":"Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics of a Strongly Coupled Polaron.” <i>Communications on Pure and Applied Mathematics</i>, vol. 74, no. 3, Wiley, 2021, pp. 544–88, doi:<a href=\"https://doi.org/10.1002/cpa.21944\">10.1002/cpa.21944</a>.","ista":"Frank R, Seiringer R. 2021. Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. Communications on Pure and Applied Mathematics. 74(3), 544–588.","ieee":"R. Frank and R. Seiringer, “Quantum corrections to the Pekar asymptotics of a strongly coupled polaron,” <i>Communications on Pure and Applied Mathematics</i>, vol. 74, no. 3. Wiley, pp. 544–588, 2021."},"author":[{"first_name":"Rupert","last_name":"Frank","full_name":"Frank, Rupert"},{"first_name":"Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert"}],"_id":"8603","file_date_updated":"2021-03-11T10:03:30Z","date_created":"2020-10-04T22:01:37Z","acknowledgement":"Partial support through National Science Foundation GrantDMS-1363432 (R.L.F.) and the European Research Council (ERC) under the Euro-pean Union’s Horizon 2020 research and innovation programme (grant agreementNo 694227; R.S.), is acknowledged. Open access funding enabled and organizedby Projekt DEAL.","article_processing_charge":"No","publication_identifier":{"issn":["0010-3640"],"eissn":["1097-0312"]},"department":[{"_id":"RoSe"}],"page":"544-588","title":"Quantum corrections to the Pekar asymptotics of a strongly coupled polaron","external_id":{"isi":["000572991500001"]},"article_type":"original","volume":74,"year":"2021","publication":"Communications on Pure and Applied Mathematics","project":[{"_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","grant_number":"694227","call_identifier":"H2020"}]},{"department":[{"_id":"JiFr"}],"date_created":"2020-10-05T12:44:33Z","acknowledgement":"We are thankful to Professor Yuxian Zhu from Wuhan University for his extremely valuable remarks and helpful comments on the manuscript. This work was supported by the Shaanxi Natural Science Foundation (2019JQ‐062 and 2020JQ‐410), Shaanxi Youth Entrusted Talents Program (20190205), China Postdoctoral Science Foundation (2018M640947, 2020T130394), Shaanxi Postdoctoral Project (2018BSHYDZZ76), Natural Science Basic Research Plan in Shaanxi Province of China (2018JZ3006), Fundamental Research Funds for the Central Universities (GK201903064, GK201901004, GK202002005 and GK202001004), and State Key Laboratory of Cotton Biology Open Fund (CB2020A12).","article_processing_charge":"No","publication_identifier":{"eissn":["1467-7652"],"issn":["1467-7644"]},"external_id":{"isi":["000577682300001"],"pmid":["32981232"]},"title":"GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton","article_type":"original","volume":19,"year":"2021","publication":"Plant Biotechnology Journal","page":"548-562","OA_place":"publisher","type":"journal_article","DOAJ_listed":"1","isi":1,"intvolume":"        19","publisher":"Wiley","author":[{"last_name":"He","first_name":"P","full_name":"He, P"},{"full_name":"Zhang, Yuzhou","orcid":"0000-0003-2627-6956","last_name":"Zhang","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","first_name":"Yuzhou"},{"full_name":"Li, H","first_name":"H","last_name":"Li"},{"first_name":"X","last_name":"Fu","full_name":"Fu, X"},{"first_name":"H","last_name":"Shang","full_name":"Shang, H"},{"first_name":"C","last_name":"Zou","full_name":"Zou, C"},{"full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jiří"},{"first_name":"G","last_name":"Xiao","full_name":"Xiao, G"}],"_id":"8606","file_date_updated":"2021-04-12T12:29:07Z","has_accepted_license":"1","scopus_import":"1","quality_controlled":"1","citation":{"mla":"He, P., et al. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1 Gene in Cotton.” <i>Plant Biotechnology Journal</i>, vol. 19, no. 3, Wiley, 2021, pp. 548–62, doi:<a href=\"https://doi.org/10.1111/pbi.13484\">10.1111/pbi.13484</a>.","ieee":"P. He <i>et al.</i>, “GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton,” <i>Plant Biotechnology Journal</i>, vol. 19, no. 3. Wiley, pp. 548–562, 2021.","ista":"He P, Zhang Y, Li H, Fu X, Shang H, Zou C, Friml J, Xiao G. 2021. GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. Plant Biotechnology Journal. 19(3), 548–562.","ama":"He P, Zhang Y, Li H, et al. GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. <i>Plant Biotechnology Journal</i>. 2021;19(3):548-562. doi:<a href=\"https://doi.org/10.1111/pbi.13484\">10.1111/pbi.13484</a>","short":"P. He, Y. Zhang, H. Li, X. Fu, H. Shang, C. Zou, J. Friml, G. Xiao, Plant Biotechnology Journal 19 (2021) 548–562.","apa":"He, P., Zhang, Y., Li, H., Fu, X., Shang, H., Zou, C., … Xiao, G. (2021). GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. <i>Plant Biotechnology Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/pbi.13484\">https://doi.org/10.1111/pbi.13484</a>","chicago":"He, P, Yuzhou Zhang, H Li, X Fu, H Shang, C Zou, Jiří Friml, and G Xiao. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1 Gene in Cotton.” <i>Plant Biotechnology Journal</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/pbi.13484\">https://doi.org/10.1111/pbi.13484</a>."},"doi":"10.1111/pbi.13484","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"OA_type":"gold","month":"03","date_published":"2021-03-01T00:00:00Z","status":"public","publication_status":"published","abstract":[{"lang":"eng","text":"The leaf is a crucial organ evolved with remarkable morphological diversity to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis, flowering rates, disease resistance, and yield. Although many genes regulating leaf development have been identified in the past years, the precise regulatory architecture underlying the generation of diverse leaf shapes remains to be elucidated. We used cotton as a reference model to probe the genetic framework underlying divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16‐1 and GhKNOX2‐1 genes might be potential regulators of leaf shape. We functionally characterized the auxin‐responsive factor ARF16‐1 acting upstream of GhKNOX2‐1 to determine leaf morphology in cotton. The transcription of GhARF16‐1 was significantly higher in lobed‐leaved cotton than in smooth‐leaved cotton. Furthermore, the overexpression of GhARF16‐1 led to the upregulation of GhKNOX2‐1 and resulted in more and deeper serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing GhKNOX2‐1. We found that GhARF16‐1 specifically bound to the promoter of GhKNOX2‐1 to induce its expression. The heterologous expression of GhARF16‐1 and GhKNOX2‐1 in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed that GhKNOX2‐1 is epistatic to GhARF16‐1 in Arabidopsis, suggesting that the GhARF16‐1 and GhKNOX2‐1 interaction paradigm also functions to regulate leaf shape in Arabidopsis. To our knowledge, our results uncover a novel mechanism by which auxin, through the key component ARF16‐1 and its downstream‐activated gene KNOX2‐1, determines leaf morphology in eudicots."}],"ddc":["580"],"file":[{"file_name":"2021_PlantBiotechJournal_He.pdf","file_size":15691871,"success":1,"file_id":"9321","date_created":"2021-04-12T12:29:07Z","checksum":"63845be37fb962586e0c7773f2355970","relation":"main_file","content_type":"application/pdf","date_updated":"2021-04-12T12:29:07Z","access_level":"open_access","creator":"dernst"}],"day":"01","language":[{"iso":"eng"}],"oa":1,"issue":"3","oa_version":"Published Version","date_updated":"2025-07-10T11:57:13Z"},{"page":"963-978","volume":229,"title":"Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana","article_type":"original","external_id":{"isi":["000573568000001"],"pmid":["32901934"]},"publication":"New Phytologist","year":"2021","article_processing_charge":"No","acknowledgement":"This work was supported by the National Key Research andDevelopment Programme of China (2017YFA0506100), theNational Natural Science Foundation of China (31870170 and31701168), and the Fok Ying Tung Education Foundation(161027) to XC; NTU startup grant (M4081533) and NIM/01/2016 (NTU, Singapore) to YM. We thank Lei Shi andZhongquan Lin for microscopy assistance.","date_created":"2020-10-05T12:45:36Z","publication_identifier":{"eissn":["1469-8137"],"issn":["0028-646x"]},"department":[{"_id":"JiFr"}],"scopus_import":"1","quality_controlled":"1","has_accepted_license":"1","citation":{"apa":"Ke, M., Ma, Z., Wang, D., Sun, Y., Wen, C., Huang, D., … Chen, X. (2021). Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16915\">https://doi.org/10.1111/nph.16915</a>","short":"M. Ke, Z. Ma, D. Wang, Y. Sun, C. Wen, D. Huang, Z. Chen, L. Yang, S. Tan, R. Li, J. Friml, Y. Miao, X. Chen, New Phytologist 229 (2021) 963–978.","chicago":"Ke, M, Z Ma, D Wang, Y Sun, C Wen, D Huang, Z Chen, et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.” <i>New Phytologist</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/nph.16915\">https://doi.org/10.1111/nph.16915</a>.","mla":"Ke, M., et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.” <i>New Phytologist</i>, vol. 229, no. 2, Wiley, 2021, pp. 963–78, doi:<a href=\"https://doi.org/10.1111/nph.16915\">10.1111/nph.16915</a>.","ieee":"M. Ke <i>et al.</i>, “Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana,” <i>New Phytologist</i>, vol. 229, no. 2. Wiley, pp. 963–978, 2021.","ista":"Ke M, Ma Z, Wang D, Sun Y, Wen C, Huang D, Chen Z, Yang L, Tan S, Li R, Friml J, Miao Y, Chen X. 2021. Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. New Phytologist. 229(2), 963–978.","ama":"Ke M, Ma Z, Wang D, et al. Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. <i>New Phytologist</i>. 2021;229(2):963-978. doi:<a href=\"https://doi.org/10.1111/nph.16915\">10.1111/nph.16915</a>"},"_id":"8608","file_date_updated":"2021-02-04T09:53:16Z","author":[{"full_name":"Ke, M","first_name":"M","last_name":"Ke"},{"full_name":"Ma, Z","first_name":"Z","last_name":"Ma"},{"full_name":"Wang, D","last_name":"Wang","first_name":"D"},{"last_name":"Sun","first_name":"Y","full_name":"Sun, Y"},{"full_name":"Wen, C","first_name":"C","last_name":"Wen"},{"last_name":"Huang","first_name":"D","full_name":"Huang, D"},{"full_name":"Chen, Z","first_name":"Z","last_name":"Chen"},{"last_name":"Yang","first_name":"L","full_name":"Yang, L"},{"full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","last_name":"Tan","first_name":"Shutang"},{"first_name":"R","last_name":"Li","full_name":"Li, R"},{"full_name":"Friml, Jiří","first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Miao, Y","last_name":"Miao","first_name":"Y"},{"last_name":"Chen","first_name":"X","full_name":"Chen, X"}],"intvolume":"       229","publisher":"Wiley","isi":1,"type":"journal_article","ddc":["580"],"publication_status":"published","abstract":[{"lang":"eng","text":"To adapt to the diverse array of biotic and abiotic cues, plants have evolved sophisticated mechanisms to sense changes in environmental conditions and modulate their growth. Growth-promoting hormones and defence signalling fine tune plant development antagonistically. During host-pathogen interactions, this defence-growth trade-off is mediated by the counteractive effects of the defence hormone salicylic acid (SA) and the growth hormone auxin. Here we revealed an underlying mechanism of SA regulating auxin signalling by constraining the plasma membrane dynamics of PIN2 auxin efflux transporter in Arabidopsis thaliana roots. The lateral diffusion of PIN2 proteins is constrained by SA signalling, during which PIN2 proteins are condensed into hyperclusters depending on REM1.2-mediated nanodomain compartmentalisation. Furthermore, membrane nanodomain compartmentalisation by SA or Remorin (REM) assembly significantly suppressed clathrin-mediated endocytosis. Consequently, SA-induced heterogeneous surface condensation disrupted asymmetric auxin distribution and the resultant gravitropic response. Our results demonstrated a defence-growth trade-off mechanism by which SA signalling crosstalked with auxin transport by concentrating membrane-resident PIN2 into heterogeneous compartments."}],"date_published":"2021-01-01T00:00:00Z","status":"public","month":"01","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","pmid":1,"doi":"10.1111/nph.16915","oa_version":"Published Version","date_updated":"2023-09-05T16:06:24Z","issue":"2","language":[{"iso":"eng"}],"oa":1,"day":"01","file":[{"date_created":"2021-02-04T09:53:16Z","file_id":"9085","checksum":"d36b6a8c6fafab66264e0d27114dae63","success":1,"file_size":3674502,"file_name":"2021_NewPhytologist_Ke.pdf","date_updated":"2021-02-04T09:53:16Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","relation":"main_file"}]},{"volume":17,"article_type":"original","external_id":{"arxiv":["2005.04228"],"isi":["000575344700003"]},"title":"Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields","publication":"Nature Physics","year":"2021","page":"240-244","department":[{"_id":"KiMo"}],"article_processing_charge":"No","acknowledgement":"We thank M. Baenitz, A. Bangura, R. Coldea, G. Jackeli, S. Kivelson, S. Nagler, R. Valenti, C. Varma, S. Winter and J. Zaanen for insightful discussions. Samples were grown at the Max Planck Institute for Chemical Physics of Solids. The d.c.-field measurements were made at the National High Magnetic Field Laboratory (NHMFL) in Tallahassee, FL. The pulsed-field measurements were made in the Pulsed Field Facility of the NHMFL in Los Alamos, NM. All work at the NHMFL is supported through the National Science Foundation Cooperative Agreement nos. DMR-1157490 and DMR-1644779, the US Department of Energy and the State of Florida. R.D.M. acknowledges support from LANL LDRD-DR 20160085 Topology and Strong Correlations. M.C. acknowledges support from the Department of Energy ‘Science of 100 tesla’ BES programme for high-field experiments. X-ray data acquisition and analysis was performed at Cornell University. Research conducted at the Cornell High Energy Synchrotron Source (CHESS) is supported by the National Science Foundation under award no. DMR-1332208. B.J.R. acknowledges support from the Institute for Quantum Matter, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Office of Basic Energy Sciences under award no. DE-SC0019331. Y.L. acknowledges support from the US Department of Energy through the LANL/LDRD programme and the G.T. Seaborg institute. J.C.P. is supported by a Gabilan Stanford Graduate Fellowship and an NSF Graduate Research Fellowship (grant no. DGE-114747). P.J.W.M. acknowledges funding from the Swiss National Science Foundation through project no. PP00P2-176789.","date_created":"2020-10-18T22:01:37Z","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"_id":"8673","author":[{"first_name":"Kimberly A","orcid":"0000-0001-9760-3147","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","last_name":"Modic","full_name":"Modic, Kimberly A"},{"first_name":"Ross D.","last_name":"McDonald","full_name":"McDonald, Ross D."},{"full_name":"Ruff, J.P.C.","last_name":"Ruff","first_name":"J.P.C."},{"first_name":"Maja D.","last_name":"Bachmann","full_name":"Bachmann, Maja D."},{"last_name":"Lai","first_name":"You","full_name":"Lai, You"},{"first_name":"Johanna C.","last_name":"Palmstrom","full_name":"Palmstrom, Johanna C."},{"last_name":"Graf","first_name":"David","full_name":"Graf, David"},{"full_name":"Chan, Mun K.","first_name":"Mun K.","last_name":"Chan"},{"full_name":"Balakirev, F.F.","last_name":"Balakirev","first_name":"F.F."},{"full_name":"Betts, J.B.","last_name":"Betts","first_name":"J.B."},{"full_name":"Boebinger, G.S.","first_name":"G.S.","last_name":"Boebinger"},{"full_name":"Schmidt, Marcus","last_name":"Schmidt","first_name":"Marcus"},{"full_name":"Lawler, Michael J.","last_name":"Lawler","first_name":"Michael J."},{"first_name":"D.A.","last_name":"Sokolov","full_name":"Sokolov, D.A."},{"full_name":"Moll, Philip J.W.","last_name":"Moll","first_name":"Philip J.W."},{"first_name":"B.J.","last_name":"Ramshaw","full_name":"Ramshaw, B.J."},{"full_name":"Shekhter, Arkady","first_name":"Arkady","last_name":"Shekhter"}],"scopus_import":"1","quality_controlled":"1","citation":{"ama":"Modic KA, McDonald RD, Ruff JPC, et al. Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. <i>Nature Physics</i>. 2021;17:240-244. doi:<a href=\"https://doi.org/10.1038/s41567-020-1028-0\">10.1038/s41567-020-1028-0</a>","ieee":"K. A. Modic <i>et al.</i>, “Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields,” <i>Nature Physics</i>, vol. 17. Springer Nature, pp. 240–244, 2021.","mla":"Modic, Kimberly A., et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at High Magnetic Fields.” <i>Nature Physics</i>, vol. 17, Springer Nature, 2021, pp. 240–44, doi:<a href=\"https://doi.org/10.1038/s41567-020-1028-0\">10.1038/s41567-020-1028-0</a>.","ista":"Modic KA, McDonald RD, Ruff JPC, Bachmann MD, Lai Y, Palmstrom JC, Graf D, Chan MK, Balakirev FF, Betts JB, Boebinger GS, Schmidt M, Lawler MJ, Sokolov DA, Moll PJW, Ramshaw BJ, Shekhter A. 2021. Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. Nature Physics. 17, 240–244.","chicago":"Modic, Kimberly A, Ross D. McDonald, J.P.C. Ruff, Maja D. Bachmann, You Lai, Johanna C. Palmstrom, David Graf, et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at High Magnetic Fields.” <i>Nature Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41567-020-1028-0\">https://doi.org/10.1038/s41567-020-1028-0</a>.","apa":"Modic, K. A., McDonald, R. D., Ruff, J. P. C., Bachmann, M. D., Lai, Y., Palmstrom, J. C., … Shekhter, A. (2021). Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-1028-0\">https://doi.org/10.1038/s41567-020-1028-0</a>","short":"K.A. Modic, R.D. McDonald, J.P.C. Ruff, M.D. Bachmann, Y. Lai, J.C. Palmstrom, D. Graf, M.K. Chan, F.F. Balakirev, J.B. Betts, G.S. Boebinger, M. Schmidt, M.J. Lawler, D.A. Sokolov, P.J.W. Moll, B.J. Ramshaw, A. Shekhter, Nature Physics 17 (2021) 240–244."},"isi":1,"type":"journal_article","intvolume":"        17","publisher":"Springer Nature","date_published":"2021-02-01T00:00:00Z","status":"public","abstract":[{"lang":"eng","text":"In RuCl3, inelastic neutron scattering and Raman spectroscopy reveal a continuum of non-spin-wave excitations that persists to high temperature, suggesting the presence of a spin liquid state on a honeycomb lattice. In the context of the Kitaev model, finite magnetic fields introduce interactions between the elementary excitations, and thus the effects of high magnetic fields that are comparable to the spin-exchange energy scale must be explored. Here, we report measurements of the magnetotropic coefficient—the thermodynamic coefficient associated with magnetic anisotropy—over a wide range of magnetic fields and temperatures. We find that magnetic field and temperature compete to determine the magnetic response in a way that is independent of the large intrinsic exchange-interaction energy. This emergent scale-invariant magnetic anisotropy provides evidence for a high degree of exchange frustration that favours the formation of a spin liquid state in RuCl3."}],"publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s41567-020-1028-0","month":"02","main_file_link":[{"url":"https://arxiv.org/abs/2005.04228","open_access":"1"}],"language":[{"iso":"eng"}],"oa":1,"date_updated":"2025-07-10T11:57:16Z","oa_version":"Preprint","arxiv":1,"corr_author":"1","day":"01"},{"isi":1,"type":"journal_article","publisher":"Springer Nature","intvolume":"        26","_id":"8689","author":[{"first_name":"Luigi","last_name":"Chierchia","full_name":"Chierchia, Luigi"},{"full_name":"Koudjinan, Edmond","orcid":"0000-0003-2640-4049","last_name":"Koudjinan","id":"52DF3E68-AEFA-11EA-95A4-124A3DDC885E","first_name":"Edmond"}],"keyword":["Nearly{integrable Hamiltonian systems","perturbation theory","KAM Theory","Arnold's scheme","Kolmogorov's set","primary invariant tori","Lagrangian tori","measure estimates","small divisors","integrability on nowhere dense sets","Diophantine frequencies."],"citation":{"ista":"Chierchia L, Koudjinan E. 2021. V.I. Arnold’s ‘“Global”’ KAM theorem and geometric measure estimates. Regular and Chaotic Dynamics. 26(1), 61–88.","mla":"Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem and Geometric Measure Estimates.” <i>Regular and Chaotic Dynamics</i>, vol. 26, no. 1, Springer Nature, 2021, pp. 61–88, doi:<a href=\"https://doi.org/10.1134/S1560354721010044\">10.1134/S1560354721010044</a>.","ieee":"L. Chierchia and E. Koudjinan, “V.I. Arnold’s ‘“Global”’ KAM theorem and geometric measure estimates,” <i>Regular and Chaotic Dynamics</i>, vol. 26, no. 1. Springer Nature, pp. 61–88, 2021.","ama":"Chierchia L, Koudjinan E. V.I. Arnold’s “‘Global’” KAM theorem and geometric measure estimates. <i>Regular and Chaotic Dynamics</i>. 2021;26(1):61-88. doi:<a href=\"https://doi.org/10.1134/S1560354721010044\">10.1134/S1560354721010044</a>","apa":"Chierchia, L., &#38; Koudjinan, E. (2021). V.I. Arnold’s “‘Global’” KAM theorem and geometric measure estimates. <i>Regular and Chaotic Dynamics</i>. Springer Nature. <a href=\"https://doi.org/10.1134/S1560354721010044\">https://doi.org/10.1134/S1560354721010044</a>","short":"L. Chierchia, E. Koudjinan, Regular and Chaotic Dynamics 26 (2021) 61–88.","chicago":"Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem and Geometric Measure Estimates.” <i>Regular and Chaotic Dynamics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1134/S1560354721010044\">https://doi.org/10.1134/S1560354721010044</a>."},"scopus_import":"1","quality_controlled":"1","department":[{"_id":"VaKa"}],"publication_identifier":{"issn":["1560-3547"]},"article_processing_charge":"No","date_created":"2020-10-21T14:56:47Z","publication":"Regular and Chaotic Dynamics","year":"2021","volume":26,"title":"V.I. Arnold's ''Global'' KAM theorem and geometric measure estimates","external_id":{"isi":["000614454700004"],"arxiv":["2010.13243"]},"article_type":"original","page":"61-88","day":"03","oa":1,"language":[{"iso":"eng"}],"arxiv":1,"oa_version":"Preprint","date_updated":"2023-08-07T13:37:27Z","issue":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1134/S1560354721010044","main_file_link":[{"url":"https://arxiv.org/abs/2010.13243","open_access":"1"}],"month":"02","status":"public","date_published":"2021-02-03T00:00:00Z","ddc":["515"],"publication_status":"published","abstract":[{"text":"This paper continues the discussion started in [CK19] concerning Arnold's legacy on classical KAM theory and (some of) its modern developments. We prove a detailed and explicit `global' Arnold's KAM Theorem, which yields, in particular, the Whitney conjugacy of a non{degenerate, real{analytic, nearly-integrable Hamiltonian system to an integrable system on a closed, nowhere dense, positive measure subset of the phase space. Detailed measure estimates on the Kolmogorov's set are provided in the case the phase space is: (A) a uniform neighbourhood of an arbitrary (bounded) set times the d-torus and (B) a domain with C2 boundary times the d-torus. All constants are explicitly given.","lang":"eng"}]},{"day":"01","oa":1,"language":[{"iso":"eng"}],"issue":"1","oa_version":"Preprint","date_updated":"2025-07-10T12:01:23Z","doi":"10.1111/jeb.13709","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"01","main_file_link":[{"url":"https://doi.org/10.1101/818559","open_access":"1"}],"date_published":"2021-01-01T00:00:00Z","status":"public","abstract":[{"lang":"eng","text":"The Mytilus complex of marine mussel species forms a mosaic of hybrid zones, found across temperate regions of the globe. This allows us to study ‘replicated’ instances of secondary contact between closely related species. Previous work on this complex has shown that local introgression is both widespread and highly heterogeneous, and has identified SNPs that are outliers of differentiation between lineages. Here, we developed an ancestry‐informative panel of such SNPs. We then compared their frequencies in newly sampled populations, including samples from within the hybrid zones, and parental populations at different distances from the contact. Results show that close to the hybrid zones, some outlier loci are near to fixation for the heterospecific allele, suggesting enhanced local introgression, or the local sweep of a shared ancestral allele. Conversely, genomic cline analyses, treating local parental populations as the reference, reveal a globally high concordance among loci, albeit with a few signals of asymmetric introgression. Enhanced local introgression at specific loci is consistent with the early transfer of adaptive variants after contact, possibly including asymmetric bi‐stable variants (Dobzhansky‐Muller incompatibilities), or haplotypes loaded with fewer deleterious mutations. Having escaped one barrier, however, these variants can be trapped or delayed at the next barrier, confining the introgression locally. These results shed light on the decay of species barriers during phases of contact."}],"publication_status":"published","type":"journal_article","isi":1,"intvolume":"        34","publisher":"Wiley","author":[{"full_name":"Simon, Alexis","first_name":"Alexis","last_name":"Simon"},{"full_name":"Fraisse, Christelle","first_name":"Christelle","last_name":"Fraisse","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8441-5075"},{"last_name":"El Ayari","first_name":"Tahani","full_name":"El Ayari, Tahani"},{"full_name":"Liautard‐Haag, Cathy","first_name":"Cathy","last_name":"Liautard‐Haag"},{"first_name":"Petr","last_name":"Strelkov","full_name":"Strelkov, Petr"},{"last_name":"Welch","first_name":"John J","full_name":"Welch, John J"},{"last_name":"Bierne","first_name":"Nicolas","full_name":"Bierne, Nicolas"}],"_id":"8708","quality_controlled":"1","scopus_import":"1","citation":{"apa":"Simon, A., Fraisse, C., El Ayari, T., Liautard‐Haag, C., Strelkov, P., Welch, J. J., &#38; Bierne, N. (2021). How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.13709\">https://doi.org/10.1111/jeb.13709</a>","short":"A. Simon, C. Fraisse, T. El Ayari, C. Liautard‐Haag, P. Strelkov, J.J. Welch, N. Bierne, Journal of Evolutionary Biology 34 (2021) 208–223.","chicago":"Simon, Alexis, Christelle Fraisse, Tahani El Ayari, Cathy Liautard‐Haag, Petr Strelkov, John J Welch, and Nicolas Bierne. “How Do Species Barriers Decay? Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” <i>Journal of Evolutionary Biology</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/jeb.13709\">https://doi.org/10.1111/jeb.13709</a>.","ista":"Simon A, Fraisse C, El Ayari T, Liautard‐Haag C, Strelkov P, Welch JJ, Bierne N. 2021. How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary Biology. 34(1), 208–223.","ieee":"A. Simon <i>et al.</i>, “How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels,” <i>Journal of Evolutionary Biology</i>, vol. 34, no. 1. Wiley, pp. 208–223, 2021.","mla":"Simon, Alexis, et al. “How Do Species Barriers Decay? Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” <i>Journal of Evolutionary Biology</i>, vol. 34, no. 1, Wiley, 2021, pp. 208–23, doi:<a href=\"https://doi.org/10.1111/jeb.13709\">10.1111/jeb.13709</a>.","ama":"Simon A, Fraisse C, El Ayari T, et al. How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. <i>Journal of Evolutionary Biology</i>. 2021;34(1):208-223. doi:<a href=\"https://doi.org/10.1111/jeb.13709\">10.1111/jeb.13709</a>"},"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"date_created":"2020-10-25T23:01:20Z","acknowledgement":"Data used in this work were partly produced through the genotyping and sequencing facilities of ISEM and LabEx CeMEB, an ANR ‘Investissements d'avenir’ program (ANR‐10‐LABX‐04‐01) This project benefited from the Montpellier Bioinformatics Biodiversity platform supported by the LabEx CeMEB. We thank Norah Saarman, Grant Pogson, Célia Gosset and Pierre‐Alexandre Gagnaire for providing samples. This work was funded by a Languedoc‐Roussillon ‘Chercheur(se)s d'Avenir’ grant (Connect7 project). P. Strelkov was supported by the Russian Science Foundation project 19‐74‐20024. This is article 2020‐240 of Institut des Sciences de l'Evolution de Montpellier.","article_processing_charge":"No","publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"article_type":"original","external_id":{"pmid":["33045123"],"isi":["000579599700001"]},"title":"How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels","volume":34,"year":"2021","publication":"Journal of Evolutionary Biology","page":"208-223","related_material":{"record":[{"id":"13073","status":"public","relation":"research_data"}]}},{"publication":"IEEE Transactions on Parallel and Distributed Systems","project":[{"name":"Elastic Coordination for Scalable Machine Learning","_id":"268A44D6-B435-11E9-9278-68D0E5697425","grant_number":"805223","call_identifier":"H2020"}],"year":"2021","volume":32,"external_id":{"arxiv":["2005.00124"],"isi":["000621405200019"]},"title":"Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging","article_type":"original","department":[{"_id":"DaAl"}],"publication_identifier":{"issn":["1045-9219"]},"article_processing_charge":"No","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Hori-\r\nzon 2020 programme under Grant DAPP, Grant 678880; EPi-GRAM-HS, Grant 801039; and ERC Starting Grant ScaleML, Grant 805223. The work of Tal Ben-Nun is supported by the Swiss National Science Foundation (Ambizione Project No. 185778). The work of Nikoli Dryden is supported by the ETH Postdoctoral Fellowship. The authors would like to thank the Swiss National Supercomputing Center for providing the computing resources and technical support.","date_created":"2020-11-05T15:25:43Z","_id":"8723","author":[{"full_name":"Li, Shigang","last_name":"Li","first_name":"Shigang"},{"full_name":"Tal Ben-Nun, Tal Ben-Nun","first_name":"Tal Ben-Nun","last_name":"Tal Ben-Nun"},{"orcid":"0000-0001-5634-0731","last_name":"Nadiradze","id":"3279A00C-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgi","full_name":"Nadiradze, Giorgi"},{"full_name":"Girolamo, Salvatore Di","first_name":"Salvatore Di","last_name":"Girolamo"},{"full_name":"Dryden, Nikoli","first_name":"Nikoli","last_name":"Dryden"},{"full_name":"Alistarh, Dan-Adrian","orcid":"0000-0003-3650-940X","last_name":"Alistarh","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","first_name":"Dan-Adrian"},{"full_name":"Hoefler, Torsten","last_name":"Hoefler","first_name":"Torsten"}],"citation":{"chicago":"Li, Shigang, Tal Ben-Nun Tal Ben-Nun, Giorgi Nadiradze, Salvatore Di Girolamo, Nikoli Dryden, Dan-Adrian Alistarh, and Torsten Hoefler. “Breaking (Global) Barriers in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” <i>IEEE Transactions on Parallel and Distributed Systems</i>. IEEE, 2021. <a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">https://doi.org/10.1109/TPDS.2020.3040606</a>.","apa":"Li, S., Tal Ben-Nun, T. B.-N., Nadiradze, G., Girolamo, S. D., Dryden, N., Alistarh, D.-A., &#38; Hoefler, T. (2021). Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. <i>IEEE Transactions on Parallel and Distributed Systems</i>. IEEE. <a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">https://doi.org/10.1109/TPDS.2020.3040606</a>","short":"S. Li, T.B.-N. Tal Ben-Nun, G. Nadiradze, S.D. Girolamo, N. Dryden, D.-A. Alistarh, T. Hoefler, IEEE Transactions on Parallel and Distributed Systems 32 (2021).","ama":"Li S, Tal Ben-Nun TB-N, Nadiradze G, et al. Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. <i>IEEE Transactions on Parallel and Distributed Systems</i>. 2021;32(7). doi:<a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">10.1109/TPDS.2020.3040606</a>","ista":"Li S, Tal Ben-Nun TB-N, Nadiradze G, Girolamo SD, Dryden N, Alistarh D-A, Hoefler T. 2021. Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. IEEE Transactions on Parallel and Distributed Systems. 32(7), 9271898.","mla":"Li, Shigang, et al. “Breaking (Global) Barriers in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” <i>IEEE Transactions on Parallel and Distributed Systems</i>, vol. 32, no. 7, 9271898, IEEE, 2021, doi:<a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">10.1109/TPDS.2020.3040606</a>.","ieee":"S. Li <i>et al.</i>, “Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging,” <i>IEEE Transactions on Parallel and Distributed Systems</i>, vol. 32, no. 7. IEEE, 2021."},"article_number":"9271898","scopus_import":"1","quality_controlled":"1","isi":1,"type":"journal_article","publisher":"IEEE","intvolume":"        32","status":"public","date_published":"2021-07-01T00:00:00Z","publication_status":"published","abstract":[{"text":"Deep learning at scale is dominated by communication time. Distributing samples across nodes usually yields the best performance, but poses scaling challenges due to global information dissemination and load imbalance across uneven sample lengths. State-of-the-art decentralized optimizers mitigate the problem, but require more iterations to achieve the same accuracy as their globally-communicating counterparts. We present Wait-Avoiding Group Model Averaging (WAGMA) SGD, a wait-avoiding stochastic optimizer that reduces global communication via subgroup weight exchange. The key insight is a combination of algorithmic changes to the averaging scheme and the use of a group allreduce operation. We prove the convergence of WAGMA-SGD, and empirically show that it retains convergence rates similar to Allreduce-SGD. For evaluation, we train ResNet-50 on ImageNet; Transformer for machine translation; and deep reinforcement learning for navigation at scale. Compared with state-of-the-art decentralized SGD variants, WAGMA-SGD significantly improves training throughput (e.g., 2.1× on 1,024 GPUs for reinforcement learning), and achieves the fastest time-to-solution (e.g., the highest score using the shortest training time for Transformer).","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1109/TPDS.2020.3040606","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2005.00124"}],"month":"07","language":[{"iso":"eng"}],"ec_funded":1,"oa":1,"arxiv":1,"date_updated":"2025-07-10T12:01:23Z","oa_version":"Preprint","issue":"7","day":"01"},{"publication":"Journal of Cerebral Blood Flow and Metabolism","year":"2021","volume":41,"article_type":"original","external_id":{"pmid":["33081568"],"isi":["000664214100012"]},"title":"Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib","page":"1634-1646","department":[{"_id":"GaNo"}],"publication_identifier":{"eissn":["1559-7016"],"issn":["0271-678x"]},"article_processing_charge":"No","date_created":"2020-11-06T08:39:01Z","_id":"8730","author":[{"last_name":"Tournier","first_name":"N","full_name":"Tournier, N"},{"last_name":"Goutal","first_name":"S","full_name":"Goutal, S"},{"full_name":"Mairinger, S","last_name":"Mairinger","first_name":"S"},{"full_name":"Lozano, IH","first_name":"IH","last_name":"Lozano"},{"full_name":"Filip, T","last_name":"Filip","first_name":"T"},{"full_name":"Sauberer, M","first_name":"M","last_name":"Sauberer"},{"full_name":"Caillé, F","first_name":"F","last_name":"Caillé"},{"last_name":"Breuil","first_name":"L","full_name":"Breuil, L"},{"first_name":"J","last_name":"Stanek","full_name":"Stanek, J"},{"first_name":"AF","last_name":"Freeman","full_name":"Freeman, AF"},{"full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","first_name":"Gaia"},{"last_name":"Truillet","first_name":"C","full_name":"Truillet, C"},{"full_name":"Wanek, T","last_name":"Wanek","first_name":"T"},{"first_name":"O","last_name":"Langer","full_name":"Langer, O"}],"citation":{"short":"N. Tournier, S. Goutal, S. Mairinger, I. Lozano, T. Filip, M. Sauberer, F. Caillé, L. Breuil, J. Stanek, A. Freeman, G. Novarino, C. Truillet, T. Wanek, O. Langer, Journal of Cerebral Blood Flow and Metabolism 41 (2021) 1634–1646.","apa":"Tournier, N., Goutal, S., Mairinger, S., Lozano, I., Filip, T., Sauberer, M., … Langer, O. (2021). Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Journal of Cerebral Blood Flow and Metabolism</i>. SAGE Publications. <a href=\"https://doi.org/10.1177/0271678X20965500\">https://doi.org/10.1177/0271678X20965500</a>","chicago":"Tournier, N, S Goutal, S Mairinger, IH Lozano, T Filip, M Sauberer, F Caillé, et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Journal of Cerebral Blood Flow and Metabolism</i>. SAGE Publications, 2021. <a href=\"https://doi.org/10.1177/0271678X20965500\">https://doi.org/10.1177/0271678X20965500</a>.","ieee":"N. Tournier <i>et al.</i>, “Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib,” <i>Journal of Cerebral Blood Flow and Metabolism</i>, vol. 41, no. 7. SAGE Publications, pp. 1634–1646, 2021.","ista":"Tournier N, Goutal S, Mairinger S, Lozano I, Filip T, Sauberer M, Caillé F, Breuil L, Stanek J, Freeman A, Novarino G, Truillet C, Wanek T, Langer O. 2021. Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal of Cerebral Blood Flow and Metabolism. 41(7), 1634–1646.","mla":"Tournier, N., et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Journal of Cerebral Blood Flow and Metabolism</i>, vol. 41, no. 7, SAGE Publications, 2021, pp. 1634–46, doi:<a href=\"https://doi.org/10.1177/0271678X20965500\">10.1177/0271678X20965500</a>.","ama":"Tournier N, Goutal S, Mairinger S, et al. Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Journal of Cerebral Blood Flow and Metabolism</i>. 2021;41(7):1634-1646. doi:<a href=\"https://doi.org/10.1177/0271678X20965500\">10.1177/0271678X20965500</a>"},"quality_controlled":"1","scopus_import":"1","isi":1,"type":"journal_article","publisher":"SAGE Publications","intvolume":"        41","status":"public","date_published":"2021-07-01T00:00:00Z","publication_status":"published","abstract":[{"text":"P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict at the blood–brain barrier (BBB) the brain distribution of the majority of currently known molecularly targeted anticancer drugs. To improve brain delivery of dual ABCB1/ABCG2 substrates, both ABCB1 and ABCG2 need to be inhibited simultaneously at the BBB. We examined the feasibility of simultaneous ABCB1/ABCG2 inhibition with i.v. co-infusion of erlotinib and tariquidar by studying brain distribution of the model ABCB1/ABCG2 substrate [11C]erlotinib in mice and rhesus macaques with PET. Tolerability of the erlotinib/tariquidar combination was assessed in human embryonic stem cell-derived cerebral organoids. In mice and macaques, baseline brain distribution of [11C]erlotinib was low (brain distribution volume, VT,brain < 0.3 mL/cm3). Co-infusion of erlotinib and tariquidar increased VT,brain in mice by 3.0-fold and in macaques by 3.4- to 5.0-fold, while infusion of erlotinib alone or tariquidar alone led to less pronounced VT,brain increases in both species. Treatment of cerebral organoids with erlotinib/tariquidar led to an induction of Caspase-3-dependent apoptosis. Co-infusion of erlotinib/tariquidar may potentially allow for complete ABCB1/ABCG2 inhibition at the BBB, while simultaneously achieving brain-targeted EGFR inhibition. Our protocol may be applicable to enhance brain delivery of molecularly targeted anticancer drugs for a more effective treatment of brain tumors.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1177/0271678X20965500","pmid":1,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221757/","open_access":"1"}],"month":"07","oa":1,"language":[{"iso":"eng"}],"date_updated":"2023-10-18T06:45:30Z","oa_version":"Published Version","issue":"7","day":"01"},{"issue":"1","oa_version":"Preprint","date_updated":"2025-04-15T07:39:01Z","arxiv":1,"oa":1,"language":[{"iso":"eng"}],"day":"01","abstract":[{"lang":"eng","text":"We develop a version of Ekedahl’s geometric sieve for integral quadratic forms of rank at least five. As one ranges over the zeros of such quadratic forms, we use the sieve to compute the density of coprime values of polynomials, and furthermore, to address a question about local solubility in families of varieties parameterised by the zeros."}],"publication_status":"published","date_published":"2021-01-01T00:00:00Z","status":"public","month":"01","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2003.09593"}],"doi":"10.1515/forum-2020-0074","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","scopus_import":"1","citation":{"ama":"Browning TD, Heath-Brown R. The geometric sieve for quadrics. <i>Forum Mathematicum</i>. 2021;33(1):147-165. doi:<a href=\"https://doi.org/10.1515/forum-2020-0074\">10.1515/forum-2020-0074</a>","ieee":"T. D. Browning and R. Heath-Brown, “The geometric sieve for quadrics,” <i>Forum Mathematicum</i>, vol. 33, no. 1. De Gruyter, pp. 147–165, 2021.","ista":"Browning TD, Heath-Brown R. 2021. The geometric sieve for quadrics. Forum Mathematicum. 33(1), 147–165.","mla":"Browning, Timothy D., and Roger Heath-Brown. “The Geometric Sieve for Quadrics.” <i>Forum Mathematicum</i>, vol. 33, no. 1, De Gruyter, 2021, pp. 147–65, doi:<a href=\"https://doi.org/10.1515/forum-2020-0074\">10.1515/forum-2020-0074</a>.","chicago":"Browning, Timothy D, and Roger Heath-Brown. “The Geometric Sieve for Quadrics.” <i>Forum Mathematicum</i>. De Gruyter, 2021. <a href=\"https://doi.org/10.1515/forum-2020-0074\">https://doi.org/10.1515/forum-2020-0074</a>.","short":"T.D. Browning, R. Heath-Brown, Forum Mathematicum 33 (2021) 147–165.","apa":"Browning, T. D., &#38; Heath-Brown, R. (2021). The geometric sieve for quadrics. <i>Forum Mathematicum</i>. De Gruyter. <a href=\"https://doi.org/10.1515/forum-2020-0074\">https://doi.org/10.1515/forum-2020-0074</a>"},"author":[{"full_name":"Browning, Timothy D","orcid":"0000-0002-8314-0177","id":"35827D50-F248-11E8-B48F-1D18A9856A87","last_name":"Browning","first_name":"Timothy D"},{"first_name":"Roger","last_name":"Heath-Brown","full_name":"Heath-Brown, Roger"}],"_id":"8742","intvolume":"        33","publisher":"De Gruyter","type":"journal_article","isi":1,"page":"147-165","title":"The geometric sieve for quadrics","external_id":{"isi":["000604750900008"],"arxiv":["2003.09593"]},"article_type":"original","volume":33,"year":"2021","project":[{"_id":"26AEDAB2-B435-11E9-9278-68D0E5697425","name":"New frontiers of the Manin conjecture","grant_number":"P32428","call_identifier":"FWF"}],"publication":"Forum Mathematicum","date_created":"2020-11-08T23:01:25Z","article_processing_charge":"No","publication_identifier":{"issn":["0933-7741"],"eissn":["1435-5337"]},"department":[{"_id":"TiBr"}]},{"publication":"Evolution","year":"2021","volume":75,"title":"Long-term cloud forest response to climate warming revealed by insect speciation history","article_type":"original","external_id":{"pmid":["33078844"],"isi":["000583190600001"]},"related_material":{"link":[{"url":"https://doi.org/10.1111/evo.14225","relation":"erratum"}]},"page":"231-244","department":[{"_id":"NiBa"}],"publication_identifier":{"issn":["0014-3820"],"eissn":["1558-5646"]},"article_processing_charge":"No","date_created":"2020-11-08T23:01:26Z","acknowledgement":"This work was financed by the Spanish Agencia Estatal de Investigación (CGL2017‐85718‐P), awarded to BCE, and co‐financed by FEDER. It was also supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (EQC2018‐004418‐P), awarded to BCE. AS‐C was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades through an FPU PhD fellowship (FPU014/02948). The authors thank Instituto Tecnológico y de Energías Renovables (ITER), S.A for providing access to the Teide High‐Performance Computing facility (Teide‐HPC). Fieldwork was supported by collecting permit AFF 107/17 (sigma number 2017‐00572) kindly provided by the Cabildo of Tenerife. The authors wish to thank the following for field work and sample sorting and identification: A. J. Pérez‐Delgado, H. López, and C. Andújar. We also thank V. García‐Olivares for assistance with laboratory and bioinformatic work.","_id":"8743","author":[{"first_name":"Antonia","last_name":"Salces-Castellano","full_name":"Salces-Castellano, Antonia"},{"full_name":"Stankowski, Sean","first_name":"Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","last_name":"Stankowski"},{"last_name":"Arribas","first_name":"Paula","full_name":"Arribas, Paula"},{"full_name":"Patino, Jairo","last_name":"Patino","first_name":"Jairo"},{"full_name":"Karger, Dirk N. ","first_name":"Dirk N. ","last_name":"Karger"},{"first_name":"Roger","last_name":"Butlin","full_name":"Butlin, Roger"},{"full_name":"Emerson, Brent C.","first_name":"Brent C.","last_name":"Emerson"}],"citation":{"ama":"Salces-Castellano A, Stankowski S, Arribas P, et al. Long-term cloud forest response to climate warming revealed by insect speciation history. <i>Evolution</i>. 2021;75(2):231-244. doi:<a href=\"https://doi.org/10.1111/evo.14111\">10.1111/evo.14111</a>","ieee":"A. Salces-Castellano <i>et al.</i>, “Long-term cloud forest response to climate warming revealed by insect speciation history,” <i>Evolution</i>, vol. 75, no. 2. Wiley, pp. 231–244, 2021.","ista":"Salces-Castellano A, Stankowski S, Arribas P, Patino J, Karger DN, Butlin R, Emerson BC. 2021. Long-term cloud forest response to climate warming revealed by insect speciation history. Evolution. 75(2), 231–244.","mla":"Salces-Castellano, Antonia, et al. “Long-Term Cloud Forest Response to Climate Warming Revealed by Insect Speciation History.” <i>Evolution</i>, vol. 75, no. 2, Wiley, 2021, pp. 231–44, doi:<a href=\"https://doi.org/10.1111/evo.14111\">10.1111/evo.14111</a>.","chicago":"Salces-Castellano, Antonia, Sean Stankowski, Paula Arribas, Jairo Patino, Dirk N.  Karger, Roger Butlin, and Brent C. Emerson. “Long-Term Cloud Forest Response to Climate Warming Revealed by Insect Speciation History.” <i>Evolution</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/evo.14111\">https://doi.org/10.1111/evo.14111</a>.","apa":"Salces-Castellano, A., Stankowski, S., Arribas, P., Patino, J., Karger, D. N., Butlin, R., &#38; Emerson, B. C. (2021). Long-term cloud forest response to climate warming revealed by insect speciation history. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.14111\">https://doi.org/10.1111/evo.14111</a>","short":"A. Salces-Castellano, S. Stankowski, P. Arribas, J. Patino, D.N. Karger, R. Butlin, B.C. Emerson, Evolution 75 (2021) 231–244."},"scopus_import":"1","quality_controlled":"1","isi":1,"type":"journal_article","publisher":"Wiley","intvolume":"        75","status":"public","date_published":"2021-02-01T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"Montane cloud forests are areas of high endemism, and are one of the more vulnerable terrestrial ecosystems to climate change. Thus, understanding how they both contribute to the generation of biodiversity, and will respond to ongoing climate change, are important and related challenges. The widely accepted model for montane cloud forest dynamics involves upslope forcing of their range limits with global climate warming. However, limited climate data provides some support for an alternative model, where range limits are forced downslope with climate warming. Testing between these two models is challenging, due to the inherent limitations of climate and pollen records. We overcome this with an alternative source of historical information, testing between competing model predictions using genomic data and demographic analyses for a species of beetle tightly associated to an oceanic island cloud forest. Results unequivocally support the alternative model: populations that were isolated at higher elevation peaks during the Last Glacial Maximum are now in contact and hybridizing at lower elevations. Our results suggest that genomic data are a rich source of information to further understand how montane cloud forest biodiversity originates, and how it is likely to be impacted by ongoing climate change."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1111/evo.14111","pmid":1,"main_file_link":[{"url":"http://hdl.handle.net/10261/223937","open_access":"1"}],"month":"02","language":[{"iso":"eng"}],"oa":1,"oa_version":"Submitted Version","date_updated":"2023-08-04T11:09:49Z","issue":"2","day":"01"},{"_id":"8757","file_date_updated":"2021-02-04T10:34:22Z","author":[{"full_name":"Bozelos, Panagiotis","id":"52e9c652-2982-11eb-81d4-b43d94c63700","last_name":"Bozelos","first_name":"Panagiotis"},{"first_name":"Tim P","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P"}],"quality_controlled":"1","scopus_import":"1","has_accepted_license":"1","citation":{"ama":"Bozelos P, Vogels TP. Talking science, online. <i>Nature Reviews Neuroscience</i>. 2021;22(1):1-2. doi:<a href=\"https://doi.org/10.1038/s41583-020-00408-6\">10.1038/s41583-020-00408-6</a>","mla":"Bozelos, Panagiotis, and Tim P. Vogels. “Talking Science, Online.” <i>Nature Reviews Neuroscience</i>, vol. 22, no. 1, Springer Nature, 2021, pp. 1–2, doi:<a href=\"https://doi.org/10.1038/s41583-020-00408-6\">10.1038/s41583-020-00408-6</a>.","ista":"Bozelos P, Vogels TP. 2021. Talking science, online. Nature Reviews Neuroscience. 22(1), 1–2.","ieee":"P. Bozelos and T. P. Vogels, “Talking science, online,” <i>Nature Reviews Neuroscience</i>, vol. 22, no. 1. Springer Nature, pp. 1–2, 2021.","chicago":"Bozelos, Panagiotis, and Tim P Vogels. “Talking Science, Online.” <i>Nature Reviews Neuroscience</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41583-020-00408-6\">https://doi.org/10.1038/s41583-020-00408-6</a>.","apa":"Bozelos, P., &#38; Vogels, T. P. (2021). Talking science, online. <i>Nature Reviews Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41583-020-00408-6\">https://doi.org/10.1038/s41583-020-00408-6</a>","short":"P. Bozelos, T.P. Vogels, Nature Reviews Neuroscience 22 (2021) 1–2."},"isi":1,"type":"journal_article","intvolume":"        22","publisher":"Springer Nature","volume":22,"article_type":"letter_note","title":"Talking science, online","external_id":{"isi":["000588256300001"],"pmid":["33173190"]},"publication":"Nature Reviews Neuroscience","year":"2021","page":"1-2","department":[{"_id":"TiVo"}],"article_processing_charge":"No","date_created":"2020-11-15T23:01:18Z","publication_identifier":{"eissn":["1471-0048"],"issn":["1471-003X"]},"oa":1,"language":[{"iso":"eng"}],"date_updated":"2025-07-10T12:01:24Z","oa_version":"Published Version","issue":"1","file":[{"date_created":"2021-02-04T10:34:22Z","file_id":"9088","checksum":"7985d7dff94c086e35b94a911d78d9ad","success":1,"file_name":"2021_NatureNeuroScience_Bozelos.pdf","file_size":683634,"date_updated":"2021-02-04T10:34:22Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","relation":"main_file"}],"day":"01","date_published":"2021-01-01T00:00:00Z","status":"public","ddc":["570"],"publication_status":"published","abstract":[{"lang":"eng","text":"Traditional scientific conferences and seminar events have been hugely disrupted by the COVID-19 pandemic, paving the way for virtual forms of scientific communication to take hold and be put to the test."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1038/s41583-020-00408-6","pmid":1,"month":"01"},{"date_published":"2021-01-01T00:00:00Z","status":"public","abstract":[{"text":"Let g be a complex semisimple Lie algebra. We give a classification of contravariant forms on the nondegenerate Whittaker g-modules Y(χ,η) introduced by Kostant. We prove that the set of all contravariant forms on Y(χ,η) forms a vector space whose dimension is given by the cardinality of the Weyl group of g. We also describe a procedure for parabolically inducing contravariant forms. As a corollary, we deduce the existence of the Shapovalov form on a Verma module, and provide a formula for the dimension of the space of contravariant forms on the degenerate Whittaker modules M(χ,η) introduced by McDowell.","lang":"eng"}],"publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1090/proc/15205","month":"01","main_file_link":[{"url":"https://arxiv.org/abs/1910.08286","open_access":"1"}],"oa":1,"language":[{"iso":"eng"}],"ec_funded":1,"oa_version":"Preprint","date_updated":"2025-04-14T07:43:50Z","issue":"1","arxiv":1,"day":"01","volume":149,"title":"Contravariant forms on Whittaker modules","external_id":{"arxiv":["1910.08286"],"isi":["000600416300004"]},"article_type":"original","project":[{"call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"}],"publication":"Proceedings of the American Mathematical Society","year":"2021","page":"37-52","department":[{"_id":"HeEd"}],"article_processing_charge":"No","acknowledgement":"We would like to thank Peter Trapa for useful discussions, and Dragan Milicic and Arun Ram for valuable feedback on the structure of the paper. The first author acknowledges the support of the European Unions Horizon 2020 research and innovation programme under the Marie Skodowska-Curie Grant Agreement No. 754411. The second author is\r\nsupported by the National Science Foundation Award No. 1803059.","date_created":"2020-11-19T10:17:40Z","publication_identifier":{"issn":["0002-9939"],"eissn":["1088-6826"]},"_id":"8773","author":[{"last_name":"Brown","id":"70B7FDF6-608D-11E9-9333-8535E6697425","first_name":"Adam","full_name":"Brown, Adam"},{"full_name":"Romanov, Anna","first_name":"Anna","last_name":"Romanov"}],"quality_controlled":"1","scopus_import":"1","keyword":["Applied Mathematics","General Mathematics"],"citation":{"short":"A. Brown, A. Romanov, Proceedings of the American Mathematical Society 149 (2021) 37–52.","apa":"Brown, A., &#38; Romanov, A. (2021). Contravariant forms on Whittaker modules. <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/proc/15205\">https://doi.org/10.1090/proc/15205</a>","chicago":"Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.” <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society, 2021. <a href=\"https://doi.org/10.1090/proc/15205\">https://doi.org/10.1090/proc/15205</a>.","ieee":"A. Brown and A. Romanov, “Contravariant forms on Whittaker modules,” <i>Proceedings of the American Mathematical Society</i>, vol. 149, no. 1. American Mathematical Society, pp. 37–52, 2021.","mla":"Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.” <i>Proceedings of the American Mathematical Society</i>, vol. 149, no. 1, American Mathematical Society, 2021, pp. 37–52, doi:<a href=\"https://doi.org/10.1090/proc/15205\">10.1090/proc/15205</a>.","ista":"Brown A, Romanov A. 2021. Contravariant forms on Whittaker modules. Proceedings of the American Mathematical Society. 149(1), 37–52.","ama":"Brown A, Romanov A. Contravariant forms on Whittaker modules. <i>Proceedings of the American Mathematical Society</i>. 2021;149(1):37-52. doi:<a href=\"https://doi.org/10.1090/proc/15205\">10.1090/proc/15205</a>"},"isi":1,"type":"journal_article","intvolume":"       149","publisher":"American Mathematical Society"},{"isi":1,"type":"journal_article","publisher":"Elsevier","intvolume":"       274","_id":"8792","author":[{"first_name":"Alice","id":"25647992-AA84-11E9-9D75-8427E6697425","last_name":"Marveggio","full_name":"Marveggio, Alice"},{"first_name":"Giulio","last_name":"Schimperna","full_name":"Schimperna, Giulio"}],"citation":{"ista":"Marveggio A, Schimperna G. 2021. On a non-isothermal Cahn-Hilliard model based on a microforce balance. Journal of Differential Equations. 274(2), 924–970.","mla":"Marveggio, Alice, and Giulio Schimperna. “On a Non-Isothermal Cahn-Hilliard Model Based on a Microforce Balance.” <i>Journal of Differential Equations</i>, vol. 274, no. 2, Elsevier, 2021, pp. 924–70, doi:<a href=\"https://doi.org/10.1016/j.jde.2020.10.030\">10.1016/j.jde.2020.10.030</a>.","ieee":"A. Marveggio and G. Schimperna, “On a non-isothermal Cahn-Hilliard model based on a microforce balance,” <i>Journal of Differential Equations</i>, vol. 274, no. 2. Elsevier, pp. 924–970, 2021.","ama":"Marveggio A, Schimperna G. On a non-isothermal Cahn-Hilliard model based on a microforce balance. <i>Journal of Differential Equations</i>. 2021;274(2):924-970. doi:<a href=\"https://doi.org/10.1016/j.jde.2020.10.030\">10.1016/j.jde.2020.10.030</a>","short":"A. Marveggio, G. Schimperna, Journal of Differential Equations 274 (2021) 924–970.","apa":"Marveggio, A., &#38; Schimperna, G. (2021). On a non-isothermal Cahn-Hilliard model based on a microforce balance. <i>Journal of Differential Equations</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jde.2020.10.030\">https://doi.org/10.1016/j.jde.2020.10.030</a>","chicago":"Marveggio, Alice, and Giulio Schimperna. “On a Non-Isothermal Cahn-Hilliard Model Based on a Microforce Balance.” <i>Journal of Differential Equations</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jde.2020.10.030\">https://doi.org/10.1016/j.jde.2020.10.030</a>."},"scopus_import":"1","quality_controlled":"1","department":[{"_id":"JuFi"}],"publication_identifier":{"issn":["0022-0396"],"eissn":["1090-2732"]},"article_processing_charge":"No","acknowledgement":"G. Schimperna has been partially supported by GNAMPA (Gruppo Nazionale per l'Analisi Matematica, la Probabilità e le loro Applicazioni) of INdAM (Istituto Nazionale di Alta Matematica).","date_created":"2020-11-22T23:01:26Z","publication":"Journal of Differential Equations","year":"2021","volume":274,"title":"On a non-isothermal Cahn-Hilliard model based on a microforce balance","external_id":{"isi":["000600845300023"],"arxiv":["2004.02618"]},"article_type":"original","page":"924-970","day":"15","language":[{"iso":"eng"}],"oa":1,"arxiv":1,"oa_version":"Preprint","date_updated":"2025-07-10T12:01:25Z","issue":"2","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1016/j.jde.2020.10.030","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2004.02618"}],"month":"02","status":"public","date_published":"2021-02-15T00:00:00Z","publication_status":"published","abstract":[{"text":"This paper is concerned with a non-isothermal Cahn-Hilliard model based on a microforce balance. The model was derived by A. Miranville and G. Schimperna starting from the two fundamental laws of Thermodynamics, following M. Gurtin's two-scale approach. The main working assumptions are made on the behaviour of the heat flux as the absolute temperature tends to zero and to infinity. A suitable Ginzburg-Landau free energy is considered. Global-in-time existence for the initial-boundary value problem associated to the entropy formulation and, in a subcase, also to the weak formulation of the model is proved by deriving suitable a priori estimates and by showing weak sequential stability of families of approximating solutions. At last, some highlights are given regarding a possible approximation scheme compatible with the a-priori estimates available for the system.","lang":"eng"}]},{"page":"83–117","title":"Area-dependent quantum field theory","external_id":{"isi":["000591139000001"]},"article_type":"original","volume":381,"year":"2021","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"publication":"Communications in Mathematical Physics","acknowledgement":"The authors thank Yuki Arano, Nils Carqueville, Alexei Davydov, Reiner Lauterbach, Pau Enrique Moliner, Chris Heunen, André Henriques, Ehud Meir, Catherine Meusburger, Gregor Schaumann, Richard Szabo and Stefan Wagner for helpful discussions and comments. We also thank the referees for their detailed comments which significantly improved the exposition of this paper. LS is supported by the DFG Research Training Group 1670 “Mathematics Inspired by String Theory and Quantum Field Theory”. Open access funding provided by Institute of Science and Technology (IST Austria).","date_created":"2020-11-29T23:01:17Z","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["1432-0916"],"issn":["0010-3616"]},"department":[{"_id":"MiLe"}],"has_accepted_license":"1","quality_controlled":"1","scopus_import":"1","citation":{"chicago":"Runkel, Ingo, and Lorant Szegedy. “Area-Dependent Quantum Field Theory.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00220-020-03902-1\">https://doi.org/10.1007/s00220-020-03902-1</a>.","apa":"Runkel, I., &#38; Szegedy, L. (2021). Area-dependent quantum field theory. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00220-020-03902-1\">https://doi.org/10.1007/s00220-020-03902-1</a>","short":"I. Runkel, L. Szegedy, Communications in Mathematical Physics 381 (2021) 83–117.","ama":"Runkel I, Szegedy L. Area-dependent quantum field theory. <i>Communications in Mathematical Physics</i>. 2021;381(1):83–117. doi:<a href=\"https://doi.org/10.1007/s00220-020-03902-1\">10.1007/s00220-020-03902-1</a>","mla":"Runkel, Ingo, and Lorant Szegedy. “Area-Dependent Quantum Field Theory.” <i>Communications in Mathematical Physics</i>, vol. 381, no. 1, Springer Nature, 2021, pp. 83–117, doi:<a href=\"https://doi.org/10.1007/s00220-020-03902-1\">10.1007/s00220-020-03902-1</a>.","ista":"Runkel I, Szegedy L. 2021. Area-dependent quantum field theory. Communications in Mathematical Physics. 381(1), 83–117.","ieee":"I. Runkel and L. Szegedy, “Area-dependent quantum field theory,” <i>Communications in Mathematical Physics</i>, vol. 381, no. 1. Springer Nature, pp. 83–117, 2021."},"author":[{"last_name":"Runkel","first_name":"Ingo","full_name":"Runkel, Ingo"},{"id":"7943226E-220E-11EA-94C7-D59F3DDC885E","last_name":"Szegedy","orcid":"0000-0003-2834-5054","first_name":"Lorant","full_name":"Szegedy, Lorant"}],"_id":"8816","file_date_updated":"2021-02-03T15:00:30Z","intvolume":"       381","publisher":"Springer Nature","type":"journal_article","isi":1,"abstract":[{"lang":"eng","text":"Area-dependent quantum field theory is a modification of two-dimensional topological quantum field theory, where one equips each connected component of a bordism with a positive real number—interpreted as area—which behaves additively under glueing. As opposed to topological theories, in area-dependent theories the state spaces can be infinite-dimensional. We introduce the notion of regularised Frobenius algebras in Hilbert spaces and show that area-dependent theories are in one-to-one correspondence to commutative regularised Frobenius algebras. We also provide a state sum construction for area-dependent theories. Our main example is two-dimensional Yang–Mills theory with compact gauge group, which we treat in detail."}],"publication_status":"published","ddc":["510"],"date_published":"2021-01-01T00:00:00Z","status":"public","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"01","doi":"10.1007/s00220-020-03902-1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1","oa_version":"Published Version","date_updated":"2025-07-10T12:01:25Z","oa":1,"language":[{"iso":"eng"}],"day":"01","file":[{"success":1,"file_name":"2021_CommMathPhys_Runkel.pdf","file_size":790526,"date_created":"2021-02-03T15:00:30Z","file_id":"9081","checksum":"6f451f9c2b74bedbc30cf884a3e02670","content_type":"application/pdf","relation":"main_file","date_updated":"2021-02-03T15:00:30Z","creator":"dernst","access_level":"open_access"}]}]