[{"scopus_import":"1","doi":"10.1214/21-EJP686","month":"09","date_published":"2021-09-28T00:00:00Z","volume":26,"ec_funded":1,"has_accepted_license":"1","file_date_updated":"2021-11-15T10:10:17Z","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"language":[{"iso":"eng"}],"article_type":"original","date_updated":"2025-04-14T07:43:47Z","publication_identifier":{"eissn":["1083-6489"]},"type":"journal_article","title":"On eigenvector statistics in the spherical and truncated unitary ensembles","year":"2021","oa_version":"Published Version","author":[{"orcid":"0000-0001-6892-8137","first_name":"Guillaume","last_name":"Dubach","full_name":"Dubach, Guillaume","id":"D5C6A458-10C4-11EA-ABF4-A4B43DDC885E"}],"abstract":[{"text":"We study the overlaps between right and left eigenvectors for random matrices of the spherical ensemble, as well as truncated unitary ensembles in the regime where half of the matrix at least is truncated. These two integrable models exhibit a form of duality, and the essential steps of our investigation can therefore be performed in parallel. In every case, conditionally on all eigenvalues, diagonal overlaps are shown to be distributed as a product of independent random variables with explicit distributions. This enables us to prove that the scaled diagonal overlaps, conditionally on one eigenvalue, converge in distribution to a heavy-tail limit, namely, the inverse of a γ2 distribution. We also provide formulae for the conditional expectation of diagonal and off-diagonal overlaps, either with respect to one eigenvalue, or with respect to the whole spectrum. These results, analogous to what is known for the complex Ginibre ensemble, can be obtained in these cases thanks to integration techniques inspired from a previous work by Forrester & Krishnapur.","lang":"eng"}],"citation":{"short":"G. Dubach, Electronic Journal of Probability 26 (2021).","mla":"Dubach, Guillaume. “On Eigenvector Statistics in the Spherical and Truncated Unitary Ensembles.” <i>Electronic Journal of Probability</i>, vol. 26, 124, Institute of Mathematical Statistics, 2021, doi:<a href=\"https://doi.org/10.1214/21-EJP686\">10.1214/21-EJP686</a>.","ieee":"G. Dubach, “On eigenvector statistics in the spherical and truncated unitary ensembles,” <i>Electronic Journal of Probability</i>, vol. 26. Institute of Mathematical Statistics, 2021.","ista":"Dubach G. 2021. On eigenvector statistics in the spherical and truncated unitary ensembles. Electronic Journal of Probability. 26, 124.","chicago":"Dubach, Guillaume. “On Eigenvector Statistics in the Spherical and Truncated Unitary Ensembles.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2021. <a href=\"https://doi.org/10.1214/21-EJP686\">https://doi.org/10.1214/21-EJP686</a>.","ama":"Dubach G. On eigenvector statistics in the spherical and truncated unitary ensembles. <i>Electronic Journal of Probability</i>. 2021;26. doi:<a href=\"https://doi.org/10.1214/21-EJP686\">10.1214/21-EJP686</a>","apa":"Dubach, G. (2021). On eigenvector statistics in the spherical and truncated unitary ensembles. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/21-EJP686\">https://doi.org/10.1214/21-EJP686</a>"},"article_number":"124","ddc":["519"],"quality_controlled":"1","acknowledgement":"We acknowledge partial support from the grants NSF DMS-1812114 of P. Bourgade (PI) and NSF CAREER DMS-1653602 of L.-P. Arguin (PI). This project has also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411. We would like to thank Paul Bourgade and László Erdős for many helpful comments.","_id":"10285","article_processing_charge":"No","oa":1,"file":[{"creator":"cchlebak","relation":"main_file","file_id":"10288","date_updated":"2021-11-15T10:10:17Z","content_type":"application/pdf","access_level":"open_access","file_size":735940,"date_created":"2021-11-15T10:10:17Z","checksum":"1c975afb31460277ce4d22b93538e5f9","file_name":"2021_ElecJournalProb_Dubach.pdf","success":1}],"publisher":"Institute of Mathematical Statistics","department":[{"_id":"LaEr"}],"publication":"Electronic Journal of Probability","status":"public","intvolume":"        26","publication_status":"published","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","day":"28","date_created":"2021-11-14T23:01:25Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"}},{"abstract":[{"text":"De novo protein synthesis is required for synapse modifications underlying stable memory encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be regulated at the synapse level is unknown. Here, we characterize neuronal signaling complexes formed by the postsynaptic scaffold GIT1, the mechanistic target of rapamycin (mTOR) kinase, and Raptor that couple synaptic stimuli to mTOR-dependent protein synthesis; and identify NMDA receptors containing GluN3A subunits as key negative regulators of GIT1 binding to mTOR. Disruption of GIT1/mTOR complexes by enhancing GluN3A expression or silencing GIT1 inhibits synaptic mTOR activation and restricts the mTOR-dependent translation of specific activity-regulated mRNAs. Conversely, GluN3A removal enables complex formation, potentiates mTOR-dependent protein synthesis, and facilitates the consolidation of associative and spatial memories in mice. The memory enhancement becomes evident with light or spaced training, can be achieved by selectively deleting GluN3A from excitatory neurons during adulthood, and does not compromise other aspects of cognition such as memory flexibility or extinction. Our findings provide mechanistic insight into synaptic translational control and reveal a potentially selective target for cognitive enhancement.","lang":"eng"}],"citation":{"ama":"Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, et al. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/elife.71575\">10.7554/elife.71575</a>","apa":"Conde-Dusman, M. J., Dey, P. N., Elía-Zudaire, Ó., Garcia Rabaneda, L. E., García-Lira, C., Grand, T., … Perez-Otaño, I. (2021). Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.71575\">https://doi.org/10.7554/elife.71575</a>","short":"M.J. Conde-Dusman, P.N. Dey, Ó. Elía-Zudaire, L.E. Garcia Rabaneda, C. García-Lira, T. Grand, V. Briz, E.R. Velasco, R. Andero Galí, S. Niñerola, A. Barco, P. Paoletti, J.F. Wesseling, F. Gardoni, S.J. Tavalin, I. Perez-Otaño, ELife 10 (2021).","mla":"Conde-Dusman, María J., et al. “Control of Protein Synthesis and Memory by GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1 Assembly.” <i>ELife</i>, vol. 10, e71575, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/elife.71575\">10.7554/elife.71575</a>.","ieee":"M. J. Conde-Dusman <i>et al.</i>, “Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021.","chicago":"Conde-Dusman, María J, Partha N Dey, Óscar Elía-Zudaire, Luis E Garcia Rabaneda, Carmen García-Lira, Teddy Grand, Victor Briz, et al. “Control of Protein Synthesis and Memory by GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1 Assembly.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/elife.71575\">https://doi.org/10.7554/elife.71575</a>.","ista":"Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Garcia Rabaneda LE, García-Lira C, Grand T, Briz V, Velasco ER, Andero Galí R, Niñerola S, Barco A, Paoletti P, Wesseling JF, Gardoni F, Tavalin SJ, Perez-Otaño I. 2021. Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. eLife. 10, e71575."},"article_number":"e71575","oa_version":"Published Version","author":[{"full_name":"Conde-Dusman, María J","first_name":"María J","last_name":"Conde-Dusman"},{"full_name":"Dey, Partha N","first_name":"Partha N","last_name":"Dey"},{"last_name":"Elía-Zudaire","first_name":"Óscar","full_name":"Elía-Zudaire, Óscar"},{"first_name":"Luis E","last_name":"Garcia Rabaneda","full_name":"Garcia Rabaneda, Luis E","id":"33D1B084-F248-11E8-B48F-1D18A9856A87"},{"full_name":"García-Lira, Carmen","last_name":"García-Lira","first_name":"Carmen"},{"last_name":"Grand","first_name":"Teddy","full_name":"Grand, Teddy"},{"last_name":"Briz","first_name":"Victor","full_name":"Briz, Victor"},{"last_name":"Velasco","first_name":"Eric R","full_name":"Velasco, Eric R"},{"last_name":"Andero Galí","first_name":"Raül","full_name":"Andero Galí, Raül"},{"first_name":"Sergio","last_name":"Niñerola","full_name":"Niñerola, Sergio"},{"first_name":"Angel","last_name":"Barco","full_name":"Barco, Angel"},{"first_name":"Pierre","last_name":"Paoletti","full_name":"Paoletti, Pierre"},{"first_name":"John F","last_name":"Wesseling","full_name":"Wesseling, John F"},{"last_name":"Gardoni","first_name":"Fabrizio","full_name":"Gardoni, Fabrizio"},{"full_name":"Tavalin, Steven J","first_name":"Steven J","last_name":"Tavalin"},{"first_name":"Isabel","last_name":"Perez-Otaño","full_name":"Perez-Otaño, Isabel"}],"title":"Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly","year":"2021","date_updated":"2024-10-21T06:02:05Z","publication_identifier":{"issn":["2050-084X"]},"type":"journal_article","language":[{"iso":"eng"}],"article_type":"original","date_published":"2021-11-17T00:00:00Z","volume":10,"has_accepted_license":"1","file_date_updated":"2021-11-18T07:02:02Z","month":"11","doi":"10.7554/elife.71575","scopus_import":"1","day":"17","date_created":"2021-11-18T06:59:45Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":"        10","keyword":["general immunology and microbiology","general biochemistry","genetics and molecular biology","general medicine","general neuroscience"],"publication_status":"published","publication":"eLife","status":"public","oa":1,"file":[{"file_name":"elife-71575-v1.pdf","checksum":"59318e9e41507cec83c2f4070e6ad540","date_created":"2021-11-18T07:02:02Z","file_size":2477302,"success":1,"relation":"main_file","file_id":"10302","creator":"lgarciar","access_level":"open_access","date_updated":"2021-11-18T07:02:02Z","content_type":"application/pdf"}],"publisher":"eLife Sciences Publications","department":[{"_id":"GaNo"}],"acknowledgement":"We thank Stuart Lipton and Nobuki Nakanishi for providing the Grin3a knockout mice, Beverly Davidson for the AAV-caRheb, Jose Esteban for help with behavioral and biochemical experiments, and Noelia Campillo, Rebeca Martínez-Turrillas, and Ana Navarro for expert technical help. Work was funded by the UTE project CIMA; fellowships from the Fundación Tatiana Pérez de Guzmán el Bueno, FEBS, and IBRO (to M.J.C.D.), Generalitat Valenciana (to O.E.-Z.), Juan de la Cierva (to L.G.R.), FPI-MINECO (to E.R.V., to S.N.) and Intertalentum postdoctoral program (to V.B.); ANR (GluBrain3A) and ERC Advanced Grants (#693021) (to P.P.); Ramón y Cajal program RYC2014-15784, RETOS-MINECO SAF2016-76565-R, ERANET-Neuron JTC 2019 ISCIII AC19/00077 FEDER funds (to R.A.); RETOS-MINECO SAF2017-87928-R (to A.B.); an NIH grant (NS76637) and UTHSC College of Medicine funds (to S.J.T.); and NARSAD Independent Investigator Award and grants from the MINECO (CSD2008-00005, SAF2013-48983R, SAF2016-80895-R), Generalitat Valenciana (PROMETEO 2019/020)(to I.P.O.) and Severo-Ochoa Excellence Awards (SEV-2013-0317, SEV-2017-0723).","_id":"10301","article_processing_charge":"No","isi":1,"ddc":["570"],"external_id":{"isi":["000720945900001"]},"quality_controlled":"1"},{"publisher":"Springer ","department":[{"_id":"LeSa"}],"file":[{"access_level":"open_access","date_updated":"2021-11-19T15:09:18Z","content_type":"application/pdf","creator":"cchlebak","file_id":"10318","relation":"main_file","success":1,"file_name":"2021_CommBio_Çoruh.pdf","file_size":6030261,"date_created":"2021-11-19T15:09:18Z","checksum":"8ffd39f2bba7152a2441802ff313bf0b"}],"oa":1,"publication":"Communications Biology","status":"public","ddc":["570"],"quality_controlled":"1","external_id":{"pmid":["33686186"],"isi":["000627440700001"]},"article_processing_charge":"No","_id":"10310","isi":1,"acknowledgement":"We are grateful for additional support and valuable scientific input for this project by Yuko Misumi, Jiannan Li, Hisako Kubota-Kawai, Takeshi Kawabata, Mian Wu, Eiki Yamashita, Atsushi Nakagawa, Volker Hartmann, Melanie Völkel and Matthias Rögner. Parts of this research were funded by the German Research Council (DFG) within the framework of GRK 2341 (Microbial Substrate Conversion) to M.M.N., the Platform Project for Supporting Drug Discovery and Life Science Research [Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from AMED under grant number JP20am0101117 (K.N.), JP16K07266 to Atsunori Oshima and C.G., a Grants-in-Aid for Scientific Research under grant number JP 25000013 (K.N.), 17H03647 (C.G.) and 16H06560 (G.K.) from MEXT-KAKENHI, the International Joint Research Promotion Program from Osaka University to M.M.N., C.G. and G.K., and the Cyclic Innovation for Clinical Empowerment (CiCLE) Grant Number JP17pc0101020 from AMED to K.N. and G.K.","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"pmid":1,"day":"08","date_created":"2021-11-19T11:37:29Z","publication_status":"published","keyword":["general agricultural and biological Sciences","general biochemistry","genetics and molecular biology","medicine (miscellaneous)"],"intvolume":"         4","has_accepted_license":"1","file_date_updated":"2021-11-19T15:09:18Z","volume":4,"date_published":"2021-03-08T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1038/s42003-021-01808-9","month":"03","author":[{"last_name":"Çoruh","first_name":"Mehmet Orkun","orcid":"0000-0002-3219-2022","id":"d25163e5-8d53-11eb-a251-e6dd8ea1b8ef","full_name":"Çoruh, Mehmet Orkun"},{"full_name":"Frank, Anna","last_name":"Frank","first_name":"Anna"},{"first_name":"Hideaki","last_name":"Tanaka","full_name":"Tanaka, Hideaki"},{"full_name":"Kawamoto, Akihiro","first_name":"Akihiro","last_name":"Kawamoto"},{"full_name":"El-Mohsnawy, Eithar","first_name":"Eithar","last_name":"El-Mohsnawy"},{"full_name":"Kato, Takayuki","first_name":"Takayuki","last_name":"Kato"},{"full_name":"Namba, Keiichi","first_name":"Keiichi","last_name":"Namba"},{"first_name":"Christoph","last_name":"Gerle","full_name":"Gerle, Christoph"},{"first_name":"Marc M.","last_name":"Nowaczyk","full_name":"Nowaczyk, Marc M."},{"full_name":"Kurisu, Genji","last_name":"Kurisu","first_name":"Genji"}],"oa_version":"Published Version","abstract":[{"lang":"eng","text":"A high-resolution structure of trimeric cyanobacterial Photosystem I (PSI) from Thermosynechococcus elongatus was reported as the first atomic model of PSI almost 20 years ago. However, the monomeric PSI structure has not yet been reported despite long-standing interest in its structure and extensive spectroscopic characterization of the loss of red chlorophylls upon monomerization. Here, we describe the structure of monomeric PSI from Thermosynechococcus elongatus BP-1. Comparison with the trimer structure gave detailed insights into monomerization-induced changes in both the central trimerization domain and the peripheral regions of the complex. Monomerization-induced loss of red chlorophylls is assigned to a cluster of chlorophylls adjacent to PsaX. Based on our findings, we propose a role of PsaX in the stabilization of red chlorophylls and that lipids of the surrounding membrane present a major source of thermal energy for uphill excitation energy transfer from red chlorophylls to P700."}],"article_number":"304","citation":{"apa":"Çoruh, M. O., Frank, A., Tanaka, H., Kawamoto, A., El-Mohsnawy, E., Kato, T., … Kurisu, G. (2021). Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster. <i>Communications Biology</i>. Springer . <a href=\"https://doi.org/10.1038/s42003-021-01808-9\">https://doi.org/10.1038/s42003-021-01808-9</a>","ama":"Çoruh MO, Frank A, Tanaka H, et al. Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster. <i>Communications Biology</i>. 2021;4(1). doi:<a href=\"https://doi.org/10.1038/s42003-021-01808-9\">10.1038/s42003-021-01808-9</a>","ieee":"M. O. Çoruh <i>et al.</i>, “Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster,” <i>Communications Biology</i>, vol. 4, no. 1. Springer , 2021.","mla":"Çoruh, Mehmet Orkun, et al. “Cryo-EM Structure of a Functional Monomeric Photosystem I from Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” <i>Communications Biology</i>, vol. 4, no. 1, 304, Springer , 2021, doi:<a href=\"https://doi.org/10.1038/s42003-021-01808-9\">10.1038/s42003-021-01808-9</a>.","ista":"Çoruh MO, Frank A, Tanaka H, Kawamoto A, El-Mohsnawy E, Kato T, Namba K, Gerle C, Nowaczyk MM, Kurisu G. 2021. Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications Biology. 4(1), 304.","chicago":"Çoruh, Mehmet Orkun, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M. Nowaczyk, and Genji Kurisu. “Cryo-EM Structure of a Functional Monomeric Photosystem I from Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” <i>Communications Biology</i>. Springer , 2021. <a href=\"https://doi.org/10.1038/s42003-021-01808-9\">https://doi.org/10.1038/s42003-021-01808-9</a>.","short":"M.O. Çoruh, A. Frank, H. Tanaka, A. Kawamoto, E. El-Mohsnawy, T. Kato, K. Namba, C. Gerle, M.M. Nowaczyk, G. Kurisu, Communications Biology 4 (2021)."},"publication_identifier":{"issn":["2399-3642"]},"type":"journal_article","date_updated":"2023-08-14T11:51:19Z","year":"2021","title":"Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster"},{"month":"11","doi":"10.1016/j.xpro.2021.100939","scopus_import":"1","language":[{"iso":"eng"}],"article_type":"original","date_published":"2021-11-10T00:00:00Z","volume":2,"ec_funded":1,"has_accepted_license":"1","project":[{"call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"name":"Role of Eed in neural stem cell lineage progression","grant_number":"T01031","_id":"268F8446-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","grant_number":"F7805","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression"}],"file_date_updated":"2021-11-22T08:23:58Z","corr_author":"1","title":"Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers","year":"2021","date_updated":"2025-04-15T08:23:07Z","publication_identifier":{"eissn":["2666-1667"]},"type":"journal_article","abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables the generation of genetic mosaic tissue in mice. MADM enables concomitant fluorescent cell labeling and introduction of a mutation of a gene of interest with single-cell resolution. This protocol highlights major steps for the generation of genetic mosaic tissue and the isolation and processing of respective tissues for downstream histological analysis. For complete details on the use and execution of this protocol, please refer to Contreras et al. (2021).","lang":"eng"}],"citation":{"apa":"Amberg, N., &#38; Hippenmeyer, S. (2021). Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.xpro.2021.100939\">https://doi.org/10.1016/j.xpro.2021.100939</a>","ama":"Amberg N, Hippenmeyer S. Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. 2021;2(4). doi:<a href=\"https://doi.org/10.1016/j.xpro.2021.100939\">10.1016/j.xpro.2021.100939</a>","ista":"Amberg N, Hippenmeyer S. 2021. Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers. STAR Protocols. 2(4), 100939.","chicago":"Amberg, Nicole, and Simon Hippenmeyer. “Genetic Mosaic Dissection of Candidate Genes in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>. Cell Press, 2021. <a href=\"https://doi.org/10.1016/j.xpro.2021.100939\">https://doi.org/10.1016/j.xpro.2021.100939</a>.","ieee":"N. Amberg and S. Hippenmeyer, “Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers,” <i>STAR Protocols</i>, vol. 2, no. 4. Cell Press, 2021.","mla":"Amberg, Nicole, and Simon Hippenmeyer. “Genetic Mosaic Dissection of Candidate Genes in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>, vol. 2, no. 4, 100939, Cell Press, 2021, doi:<a href=\"https://doi.org/10.1016/j.xpro.2021.100939\">10.1016/j.xpro.2021.100939</a>.","short":"N. Amberg, S. Hippenmeyer, STAR Protocols 2 (2021)."},"article_number":"100939","oa_version":"Published Version","author":[{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole","last_name":"Amberg","first_name":"Nicole","orcid":"0000-0002-3183-8207"},{"first_name":"Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"}],"acknowledgement":"This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Bioimaging (BIF) and Preclinical Facilities (PCF). We particularly thank Mohammad Goudarzi for assistance with photography of mouse perfusion and dissection. N.A. received support from FWF Firnberg-Programm (T 1031). This work was also supported by IST Austria institutional funds; FWF SFB F78 to S.H.; and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 725780 LinPro) to S.H.","_id":"10321","article_processing_charge":"Yes","ddc":["573"],"quality_controlled":"1","publication":"STAR Protocols","status":"public","oa":1,"file":[{"date_updated":"2021-11-22T08:23:58Z","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"10329","creator":"cchlebak","success":1,"checksum":"9e3f6d06bf583e7a8b6a9e9a60500a28","date_created":"2021-11-22T08:23:58Z","file_size":7309464,"file_name":"2021_STARProtocols_Amberg.pdf"}],"publisher":"Cell Press","department":[{"_id":"SiHi"}],"intvolume":"         2","publication_status":"published","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"day":"10","date_created":"2021-11-21T23:01:28Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"issue":"4","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87"},{"article_number":"e3001431","citation":{"short":"L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.J. Mann, A. Lopez-Clavijo, H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger, K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, PLoS Biology 19 (2021).","mla":"Chauve, Laetitia, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.” <i>PLoS Biology</i>, vol. 19, no. 11, e3001431, Public Library of Science, 2021, doi:<a href=\"https://doi.org/10.1371/journal.pbio.3001431\">10.1371/journal.pbio.3001431</a>.","ieee":"L. Chauve <i>et al.</i>, “Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans,” <i>PLoS Biology</i>, vol. 19, no. 11. Public Library of Science, 2021.","ista":"Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann HJ, Lopez-Clavijo A, Okkenhaug H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. PLoS Biology. 19(11), e3001431.","chicago":"Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh, Harry Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.” <i>PLoS Biology</i>. Public Library of Science, 2021. <a href=\"https://doi.org/10.1371/journal.pbio.3001431\">https://doi.org/10.1371/journal.pbio.3001431</a>.","ama":"Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. <i>PLoS Biology</i>. 2021;19(11). doi:<a href=\"https://doi.org/10.1371/journal.pbio.3001431\">10.1371/journal.pbio.3001431</a>","apa":"Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H. J., Lopez-Clavijo, A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.3001431\">https://doi.org/10.1371/journal.pbio.3001431</a>"},"abstract":[{"text":"To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR), causes extensive fat remodeling in peripheral tissues. These changes include a decrease in fat desaturase and acid lipase expression in the intestine and a global shift in the saturation levels of plasma membrane’s phospholipids. The observed remodeling of plasma membrane is in line with ectothermic adaptive responses and gives worms a cumulative advantage to warm temperatures. We have determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone morphogenetic protein (BMP) are required for signaling across tissues to modulate fat desaturation. We also find neuronal hsf-1 is not only sufficient but also partially necessary to control the fat remodeling response and for survival at warm temperatures. This is the first study to show that a thermostat-based mechanism can cell nonautonomously coordinate membrane saturation and composition across tissues in a multicellular animal.","lang":"eng"}],"author":[{"first_name":"Laetitia","last_name":"Chauve","full_name":"Chauve, Laetitia"},{"last_name":"Hodge","first_name":"Francesca","full_name":"Hodge, Francesca"},{"last_name":"Murdoch","first_name":"Sharlene","full_name":"Murdoch, Sharlene"},{"full_name":"Masoudzadeh, Fatemah","last_name":"Masoudzadeh","first_name":"Fatemah"},{"last_name":"Mann","first_name":"Harry Jack","full_name":"Mann, Harry Jack"},{"last_name":"Lopez-Clavijo","first_name":"Andrea","full_name":"Lopez-Clavijo, Andrea"},{"last_name":"Okkenhaug","first_name":"Hanneke","full_name":"Okkenhaug, Hanneke"},{"full_name":"West, Greg","last_name":"West","first_name":"Greg"},{"first_name":"Bebiana C.","last_name":"Sousa","full_name":"Sousa, Bebiana C."},{"first_name":"Anne","last_name":"Segonds-Pichon","full_name":"Segonds-Pichon, Anne"},{"first_name":"Cheryl","last_name":"Li","full_name":"Li, Cheryl"},{"first_name":"Steven","last_name":"Wingett","full_name":"Wingett, Steven"},{"full_name":"Kienberger, Hermine","last_name":"Kienberger","first_name":"Hermine"},{"full_name":"Kleigrewe, Karin","first_name":"Karin","last_name":"Kleigrewe"},{"orcid":"0000-0001-8347-0443","first_name":"Mario","last_name":"De Bono","full_name":"De Bono, Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Wakelam","first_name":"Michael","full_name":"Wakelam, Michael"},{"full_name":"Casanueva, Olivia","first_name":"Olivia","last_name":"Casanueva"}],"oa_version":"Published Version","year":"2021","title":"Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans","related_material":{"record":[{"id":"13069","relation":"research_data","status":"public"}]},"type":"journal_article","publication_identifier":{"issn":["1544-9173"],"eissn":["1545-7885"]},"date_updated":"2023-08-14T11:53:27Z","article_type":"original","language":[{"iso":"eng"}],"has_accepted_license":"1","file_date_updated":"2021-11-22T09:34:03Z","date_published":"2021-11-01T00:00:00Z","volume":19,"month":"11","doi":"10.1371/journal.pbio.3001431","scopus_import":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"issue":"11","day":"01","date_created":"2021-11-21T23:01:28Z","pmid":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","intvolume":"        19","status":"public","publication":"PLoS Biology","department":[{"_id":"MaDe"}],"publisher":"Public Library of Science","oa":1,"file":[{"file_name":"2021_PLoSBio_Chauve.pdf","date_created":"2021-11-22T09:34:03Z","file_size":4069215,"checksum":"0c61b667f814fd9435b3ac42036fc36d","success":1,"creator":"cchlebak","relation":"main_file","file_id":"10330","access_level":"open_access","date_updated":"2021-11-22T09:34:03Z","content_type":"application/pdf"}],"isi":1,"_id":"10322","article_processing_charge":"No","acknowledgement":"We dedicate this work to the memory of Michael J.O. Wakelam. We would like to acknowledge Michael Fasseas (Invermis, Magnitude Biosciences) for plasmid injections and Sunny Biotech for transgenics; Catalina Vallejos and John Marioni for statistical advice at the beginning of the work; Simon Walker, Imaging, Bioinformatics and Lipidomics Facilities at Babraham Institute for technical support; and Cindy Voisine, Michael Witting, Jon Houseley, Len Stephens, Carmen Nussbaum Krammer, Rebeca Aldunate, Patricija van Oosten-Hawle, Jean-Louis Bessereau, and Jane Alfred for feedback on the manuscript. We thank Andy Dillin, Atsushi Kuhara, Amy Walker, Andrew Leifer, Yun Zhang, and Michalis Barkoulas for reagents and Julie Ahringer, Anne Ferguson-Smith, and Anne Corcoran for support and helpful discussions. We also acknowledge Babraham Institute Facilities.","quality_controlled":"1","external_id":{"pmid":["34723964"],"isi":["000715818400001"]},"ddc":["570"]},{"publisher":"Frontiers","department":[{"_id":"PaSc"}],"oa":1,"file":[{"file_size":4700798,"date_created":"2021-11-23T15:06:58Z","checksum":"a5c9dbf80dc2c5aaa737f456c941d964","file_name":"2021_FrontiersMolBioSc_Sučec.pdf","success":1,"creator":"cchlebak","relation":"main_file","file_id":"10333","date_updated":"2021-11-23T15:06:58Z","content_type":"application/pdf","access_level":"open_access"}],"publication":"Frontiers in Molecular Biosciences","status":"public","ddc":["547"],"external_id":{"isi":["000717241700001"],"pmid":["34760928"]},"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","_id":"10323","isi":1,"acknowledgement":"We thank Juan C. Fontecilla-Camps for insightful discussions related to ATP-driven machineries, and Elif Karagöz for providing the structural model of the Hsp90-Tau complex. This study was supported by the European Research Council (StG-2012-311318-ProtDyn2Function) and the Agence Nationale de la Recherche (ANR-18-CE92-0032-MitoMemProtImp).","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"pmid":1,"day":"25","date_created":"2021-11-21T23:01:29Z","publication_status":"published","intvolume":"         8","has_accepted_license":"1","file_date_updated":"2021-11-23T15:06:58Z","corr_author":"1","volume":8,"date_published":"2021-10-25T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.3389/fmolb.2021.762005","month":"10","author":[{"last_name":"Sučec","first_name":"Iva","full_name":"Sučec, Iva"},{"full_name":"Bersch, Beate","last_name":"Bersch","first_name":"Beate"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","last_name":"Schanda","first_name":"Paul","orcid":"0000-0002-9350-7606"}],"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Molecular chaperones are central to cellular protein homeostasis. Dynamic disorder is a key feature of the complexes of molecular chaperones and their client proteins, and it facilitates the client release towards a folded state or the handover to downstream components. The dynamic nature also implies that a given chaperone can interact with many different client proteins, based on physico-chemical sequence properties rather than on structural complementarity of their (folded) 3D structure. Yet, the balance between this promiscuity and some degree of client specificity is poorly understood. Here, we review recent atomic-level descriptions of chaperones with client proteins, including chaperones in complex with intrinsically disordered proteins, with membrane-protein precursors, or partially folded client proteins. We focus hereby on chaperone-client interactions that are independent of ATP. The picture emerging from these studies highlights the importance of dynamics in these complexes, whereby several interaction types, not only hydrophobic ones, contribute to the complex formation. We discuss these features of chaperone-client complexes and possible factors that may contribute to this balance of promiscuity and specificity."}],"article_number":"762005","citation":{"apa":"Sučec, I., Bersch, B., &#38; Schanda, P. (2021). How do chaperones bind (partly) unfolded client proteins? <i>Frontiers in Molecular Biosciences</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmolb.2021.762005\">https://doi.org/10.3389/fmolb.2021.762005</a>","ama":"Sučec I, Bersch B, Schanda P. How do chaperones bind (partly) unfolded client proteins? <i>Frontiers in Molecular Biosciences</i>. 2021;8. doi:<a href=\"https://doi.org/10.3389/fmolb.2021.762005\">10.3389/fmolb.2021.762005</a>","chicago":"Sučec, Iva, Beate Bersch, and Paul Schanda. “How Do Chaperones Bind (Partly) Unfolded Client Proteins?” <i>Frontiers in Molecular Biosciences</i>. Frontiers, 2021. <a href=\"https://doi.org/10.3389/fmolb.2021.762005\">https://doi.org/10.3389/fmolb.2021.762005</a>.","ista":"Sučec I, Bersch B, Schanda P. 2021. How do chaperones bind (partly) unfolded client proteins? Frontiers in Molecular Biosciences. 8, 762005.","ieee":"I. Sučec, B. Bersch, and P. Schanda, “How do chaperones bind (partly) unfolded client proteins?,” <i>Frontiers in Molecular Biosciences</i>, vol. 8. Frontiers, 2021.","mla":"Sučec, Iva, et al. “How Do Chaperones Bind (Partly) Unfolded Client Proteins?” <i>Frontiers in Molecular Biosciences</i>, vol. 8, 762005, Frontiers, 2021, doi:<a href=\"https://doi.org/10.3389/fmolb.2021.762005\">10.3389/fmolb.2021.762005</a>.","short":"I. Sučec, B. Bersch, P. Schanda, Frontiers in Molecular Biosciences 8 (2021)."},"publication_identifier":{"eissn":["2296-889X"]},"type":"journal_article","date_updated":"2024-10-09T21:01:12Z","year":"2021","title":"How do chaperones bind (partly) unfolded client proteins?"},{"author":[{"last_name":"Avarikioti","first_name":"Zeta","full_name":"Avarikioti, Zeta"},{"id":"f5983044-d7ef-11ea-ac6d-fd1430a26d30","full_name":"Kokoris Kogias, Eleftherios","last_name":"Kokoris Kogias","first_name":"Eleftherios"},{"full_name":"Wattenhofer, Roger","first_name":"Roger","last_name":"Wattenhofer"},{"full_name":"Zindros, Dionysis","first_name":"Dionysis","last_name":"Zindros"}],"oa_version":"Preprint","conference":{"start_date":"2021-03-01","location":"Virtual","end_date":"2021-03-05","name":"FC: Financial Cryptography"},"abstract":[{"lang":"eng","text":"Off-chain protocols (channels) are a promising solution to the scalability and privacy challenges of blockchain payments. Current proposals, however, require synchrony assumptions to preserve the safety of a channel, leaking to an adversary the exact amount of time needed to control the network for a successful attack. In this paper, we introduce Brick, the first payment channel that remains secure under network asynchrony and concurrently provides correct incentives. The core idea is to incorporate the conflict resolution process within the channel by introducing a rational committee of external parties, called wardens. Hence, if a party wants to close a channel unilaterally, it can only get the committee’s approval for the last valid state. Additionally, Brick provides sub-second latency because it does not employ heavy-weight consensus. Instead, Brick uses consistent broadcast to announce updates and close the channel, a light-weight abstraction that is powerful enough to preserve safety and liveness to any rational parties. We formally define and prove for Brick the properties a payment channel construction should fulfill. We also design incentives for Brick such that honest and rational behavior aligns. Finally, we provide a reference implementation of the smart contracts in Solidity."}],"citation":{"mla":"Avarikioti, Zeta, et al. “Brick: Asynchronous Incentive-Compatible Payment Channels.” <i>25th International Conference on Financial Cryptography and Data Security</i>, vol. 12675, Springer Nature, 2021, pp. 209–30, doi:<a href=\"https://doi.org/10.1007/978-3-662-64331-0_11\">10.1007/978-3-662-64331-0_11</a>.","ieee":"Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, and D. Zindros, “Brick: Asynchronous incentive-compatible payment channels,” in <i>25th International Conference on Financial Cryptography and Data Security</i>, Virtual, 2021, vol. 12675, pp. 209–230.","chicago":"Avarikioti, Zeta, Eleftherios Kokoris Kogias, Roger Wattenhofer, and Dionysis Zindros. “Brick: Asynchronous Incentive-Compatible Payment Channels.” In <i>25th International Conference on Financial Cryptography and Data Security</i>, 12675:209–30. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-662-64331-0_11\">https://doi.org/10.1007/978-3-662-64331-0_11</a>.","ista":"Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. 2021. Brick: Asynchronous incentive-compatible payment channels. 25th International Conference on Financial Cryptography and Data Security. FC: Financial Cryptography, LNCS, vol. 12675, 209–230.","short":"Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, D. Zindros, in:, 25th International Conference on Financial Cryptography and Data Security, Springer Nature, 2021, pp. 209–230.","apa":"Avarikioti, Z., Kokoris Kogias, E., Wattenhofer, R., &#38; Zindros, D. (2021). Brick: Asynchronous incentive-compatible payment channels. In <i>25th International Conference on Financial Cryptography and Data Security</i> (Vol. 12675, pp. 209–230). Virtual: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-662-64331-0_11\">https://doi.org/10.1007/978-3-662-64331-0_11</a>","ama":"Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. Brick: Asynchronous incentive-compatible payment channels. In: <i>25th International Conference on Financial Cryptography and Data Security</i>. Vol 12675. Springer Nature; 2021:209-230. doi:<a href=\"https://doi.org/10.1007/978-3-662-64331-0_11\">10.1007/978-3-662-64331-0_11</a>"},"publication_identifier":{"eisbn":["978-3-662-64331-0"],"eissn":["1611-3349"],"isbn":["9-783-6626-4330-3"],"issn":["0302-9743"]},"type":"conference","arxiv":1,"date_updated":"2023-08-14T12:59:58Z","year":"2021","title":"Brick: Asynchronous incentive-compatible payment channels","volume":"12675 ","date_published":"2021-10-23T00:00:00Z","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1007/978-3-662-64331-0_11","month":"10","main_file_link":[{"url":"https://arxiv.org/abs/1905.11360","open_access":"1"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","day":"23","date_created":"2021-11-21T23:01:29Z","publication_status":"published","publisher":"Springer Nature","page":"209-230","department":[{"_id":"ElKo"}],"oa":1,"publication":"25th International Conference on Financial Cryptography and Data Security","alternative_title":["LNCS"],"status":"public","quality_controlled":"1","external_id":{"arxiv":["1905.11360"],"isi":["000712016200011"]},"_id":"10324","article_processing_charge":"No","isi":1,"acknowledgement":"We would like to thank Kaoutar Elkhiyaoui for her valuable feedback as well as Jakub Sliwinski for his impactful contribution to this work."},{"oa":1,"file":[{"access_level":"open_access","date_updated":"2025-01-21T12:41:43Z","content_type":"application/pdf","creator":"dernst","relation":"main_file","file_id":"18864","success":1,"file_name":"Accepted version_Xu et al.,2021 Catabolism of strigolactones by a carboxylesterase.pdf","date_created":"2025-01-21T12:41:43Z","file_size":41109943,"checksum":"d20231806bea67f0fd19e96a94a048f4"}],"publisher":"Springer Nature","page":"1495–1504 ","department":[{"_id":"JiFr"}],"publication":"Nature Plants","status":"public","OA_place":"repository","ddc":["580"],"external_id":{"pmid":["34764442"],"isi":["000717408000002"]},"quality_controlled":"1","acknowledgement":"We thank J. Li (Institute of Genetics and Developmental Biology, China) for providing the at14-1, atmax2-1, atmax3-9, atmax4-1, atmax1-1, kai2-2 (Col-0 background) mutants and B. Xu for providing the complementary DNA of P. patens. We are grateful to L. Wang for assistance with MST, B. Han for assistance with UPLC–MS, J. Li for assistance with confocal microscopy and B. Mikael and J. Zhang for their comments on the manuscript. This work was supported by grants from Strategic Priority Research Program of Chinese Academy of Sciences (Y.H., XDB27030102) and the National Natural Science Foundation of China (E.X., 31700253; Y.H., 31830055).","OA_type":"green","_id":"10326","article_processing_charge":"No","isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"day":"11","date_created":"2021-11-21T23:01:30Z","intvolume":"         7","publication_status":"published","volume":7,"date_published":"2021-11-11T00:00:00Z","file_date_updated":"2025-01-21T12:41:43Z","has_accepted_license":"1","language":[{"iso":"eng"}],"article_type":"original","scopus_import":"1","doi":"10.1038/s41477-021-01011-y","month":"11","oa_version":"Submitted Version","author":[{"last_name":"Xu","first_name":"Enjun","full_name":"Xu, Enjun"},{"full_name":"Chai, Liang","last_name":"Chai","first_name":"Liang"},{"first_name":"Shiqi","last_name":"Zhang","full_name":"Zhang, Shiqi"},{"last_name":"Yu","first_name":"Ruixue","full_name":"Yu, Ruixue"},{"full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","first_name":"Xixi","orcid":"0000-0001-7048-4627","last_name":"Zhang"},{"full_name":"Xu, Chongyi","first_name":"Chongyi","last_name":"Xu"},{"first_name":"Yuxin","last_name":"Hu","full_name":"Hu, Yuxin"}],"abstract":[{"text":"Strigolactones (SLs) are carotenoid-derived plant hormones that control shoot branching and communications between host plants and symbiotic fungi or root parasitic plants. Extensive studies have identified the key components participating in SL biosynthesis and signalling, whereas the catabolism or deactivation of endogenous SLs in planta remains largely unknown. Here, we report that the Arabidopsis carboxylesterase 15 (AtCXE15) and its orthologues function as efficient hydrolases of SLs. We show that overexpression of AtCXE15 promotes shoot branching by dampening SL-inhibited axillary bud outgrowth. We further demonstrate that AtCXE15 could bind and efficiently hydrolyse SLs both in vitro and in planta. We also provide evidence that AtCXE15 is capable of catalysing hydrolysis of diverse SL analogues and that such CXE15-dependent catabolism of SLs is evolutionarily conserved in seed plants. These results disclose a catalytic mechanism underlying homoeostatic regulation of SLs in plants, which also provides a rational approach to spatial-temporally manipulate the endogenous SLs and thus architecture of crops and ornamental plants.","lang":"eng"}],"citation":{"ama":"Xu E, Chai L, Zhang S, et al. Catabolism of strigolactones by a carboxylesterase. <i>Nature Plants</i>. 2021;7:1495–1504. doi:<a href=\"https://doi.org/10.1038/s41477-021-01011-y\">10.1038/s41477-021-01011-y</a>","apa":"Xu, E., Chai, L., Zhang, S., Yu, R., Zhang, X., Xu, C., &#38; Hu, Y. (2021). Catabolism of strigolactones by a carboxylesterase. <i>Nature Plants</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41477-021-01011-y\">https://doi.org/10.1038/s41477-021-01011-y</a>","short":"E. Xu, L. Chai, S. Zhang, R. Yu, X. Zhang, C. Xu, Y. Hu, Nature Plants 7 (2021) 1495–1504.","ieee":"E. Xu <i>et al.</i>, “Catabolism of strigolactones by a carboxylesterase,” <i>Nature Plants</i>, vol. 7. Springer Nature, pp. 1495–1504, 2021.","mla":"Xu, Enjun, et al. “Catabolism of Strigolactones by a Carboxylesterase.” <i>Nature Plants</i>, vol. 7, Springer Nature, 2021, pp. 1495–1504, doi:<a href=\"https://doi.org/10.1038/s41477-021-01011-y\">10.1038/s41477-021-01011-y</a>.","ista":"Xu E, Chai L, Zhang S, Yu R, Zhang X, Xu C, Hu Y. 2021. Catabolism of strigolactones by a carboxylesterase. Nature Plants. 7, 1495–1504.","chicago":"Xu, Enjun, Liang Chai, Shiqi Zhang, Ruixue Yu, Xixi Zhang, Chongyi Xu, and Yuxin Hu. “Catabolism of Strigolactones by a Carboxylesterase.” <i>Nature Plants</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41477-021-01011-y\">https://doi.org/10.1038/s41477-021-01011-y</a>."},"date_updated":"2025-01-21T12:42:52Z","publication_identifier":{"eissn":["2055-0278"]},"type":"journal_article","title":"Catabolism of strigolactones by a carboxylesterase","year":"2021"},{"scopus_import":"1","month":"11","doi":"10.1038/s41567-021-01374-1","corr_author":"1","project":[{"name":"Design Principles of Branching Morphogenesis","grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"},{"call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639"}],"file_date_updated":"2023-10-11T09:31:43Z","has_accepted_license":"1","ec_funded":1,"volume":17,"date_published":"2021-11-18T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"type":"journal_article","publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"date_updated":"2025-04-14T07:52:26Z","year":"2021","title":"Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation","related_material":{"link":[{"url":"https://ist.ac.at/en/news/how-cells-feel-curvature/","description":"News on IST Webpage","relation":"press_release"}]},"author":[{"first_name":"Marine","last_name":"Luciano","full_name":"Luciano, Marine"},{"id":"31D2C804-F248-11E8-B48F-1D18A9856A87","full_name":"Xue, Shi-lei","last_name":"Xue","first_name":"Shi-lei"},{"full_name":"De Vos, Winnok H.","first_name":"Winnok H.","last_name":"De Vos"},{"first_name":"Lorena","last_name":"Redondo-Morata","full_name":"Redondo-Morata, Lorena"},{"first_name":"Mathieu","last_name":"Surin","full_name":"Surin, Mathieu"},{"last_name":"Lafont","first_name":"Frank","full_name":"Lafont, Frank"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Gabriele","first_name":"Sylvain","full_name":"Gabriele, Sylvain"}],"oa_version":"Submitted Version","citation":{"short":"M. Luciano, S. Xue, W.H. De Vos, L. Redondo-Morata, M. Surin, F. Lafont, E.B. Hannezo, S. Gabriele, Nature Physics 17 (2021) 1382–1390.","ieee":"M. Luciano <i>et al.</i>, “Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation,” <i>Nature Physics</i>, vol. 17, no. 12. Springer Nature, pp. 1382–1390, 2021.","mla":"Luciano, Marine, et al. “Cell Monolayers Sense Curvature by Exploiting Active Mechanics and Nuclear Mechanoadaptation.” <i>Nature Physics</i>, vol. 17, no. 12, Springer Nature, 2021, pp. 1382–1390, doi:<a href=\"https://doi.org/10.1038/s41567-021-01374-1\">10.1038/s41567-021-01374-1</a>.","ista":"Luciano M, Xue S, De Vos WH, Redondo-Morata L, Surin M, Lafont F, Hannezo EB, Gabriele S. 2021. Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation. Nature Physics. 17(12), 1382–1390.","chicago":"Luciano, Marine, Shi-lei Xue, Winnok H. De Vos, Lorena Redondo-Morata, Mathieu Surin, Frank Lafont, Edouard B Hannezo, and Sylvain Gabriele. “Cell Monolayers Sense Curvature by Exploiting Active Mechanics and Nuclear Mechanoadaptation.” <i>Nature Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41567-021-01374-1\">https://doi.org/10.1038/s41567-021-01374-1</a>.","ama":"Luciano M, Xue S, De Vos WH, et al. Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation. <i>Nature Physics</i>. 2021;17(12):1382–1390. doi:<a href=\"https://doi.org/10.1038/s41567-021-01374-1\">10.1038/s41567-021-01374-1</a>","apa":"Luciano, M., Xue, S., De Vos, W. H., Redondo-Morata, L., Surin, M., Lafont, F., … Gabriele, S. (2021). Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-021-01374-1\">https://doi.org/10.1038/s41567-021-01374-1</a>"},"abstract":[{"text":"The early development of many organisms involves the folding of cell monolayers, but this behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of local curvature remain unclear. Here we study epithelial cell monolayers on corrugated hydrogels engineered into wavy patterns, examining how concave and convex curvatures affect cellular and nuclear shape. We find that substrate curvature affects monolayer thickness, which is larger in valleys than crests. We show that this feature generically arises in a vertex model, leading to the hypothesis that cells may sense curvature by modifying the thickness of the tissue. We find that local curvature also affects nuclear morphology and positioning, which we explain by extending the vertex model to take into account membrane–nucleus interactions, encoding thickness modulation in changes to nuclear deformation and position. We propose that curvature governs the spatial distribution of yes-associated proteins via nuclear shape and density changes. We show that curvature also induces significant variations in lamins, chromatin condensation and cell proliferation rate in folded epithelial tissues. Together, this work identifies active cell mechanics and nuclear mechanoadaptation as the key players of the mechanistic regulation of epithelia to substrate curvature.","lang":"eng"}],"external_id":{"isi":["000720204300004"]},"quality_controlled":"1","ddc":["530"],"isi":1,"article_processing_charge":"No","_id":"10365","acknowledgement":"S.G. acknowledges funding from FEDER Prostem Research Project no. 1510614 (Wallonia DG06), F.R.S.-FNRS Epiforce Research Project no. T.0092.21 and Interreg MAT(T)ISSE project, which is financially supported by Interreg France-Wallonie-Vlaanderen (Fonds Européen de Développement Régional, FEDER-ERDF). This project was supported by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme grant agreement 851288 (to E.H.), and by the Austrian Science Fund (FWF) (P 31639; to E.H.). L.R.M. acknowledges funding from the Agence National de la Recherche (ANR), as part of the ‘Investments d’Avenir’ Programme (I-SITE ULNE/ANR-16-IDEX-0004 ULNE). This work benefited from ANR-10-EQPX-04-01 and FEDER 12001407 grants to F.L. W.D.V. is supported by the Research Foundation Flanders (FWO 1516619N, FWO GOO5819N, FWO I003420N, FWO IRI I000321N) and is member of the Research Excellence Consortium µNEURO at the University of Antwerp. M.L. is financially supported by FRIA (F.R.S.-FNRS). M.S. is a Senior Research Associate of the Fund for Scientific Research (F.R.S.-FNRS) and acknowledges EOS grant no. 30650939 (PRECISION). Sketches in Figs. 1a and 5e and Extended Data Fig. 9 were drawn by C. Levicek.","department":[{"_id":"EdHa"}],"page":"1382–1390","publisher":"Springer Nature","oa":1,"file":[{"date_updated":"2023-10-11T09:31:43Z","content_type":"application/pdf","access_level":"open_access","creator":"channezo","relation":"main_file","file_id":"14420","success":1,"file_size":40285498,"date_created":"2023-10-11T09:31:43Z","checksum":"5d6d76750a71d7cb632bb15417c38ef7","file_name":"50145_4_merged_1630498627.pdf"}],"status":"public","publication":"Nature Physics","publication_status":"published","intvolume":"        17","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"12","date_created":"2021-11-28T23:01:29Z","day":"18"},{"author":[{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"Ana Maria","last_name":"Lennon","full_name":"Lennon, Ana Maria"},{"full_name":"Mayor, Roberto","last_name":"Mayor","first_name":"Roberto"},{"last_name":"Salbreux","first_name":"Guillaume","full_name":"Salbreux, Guillaume"}],"oa_version":"Published Version","citation":{"ista":"Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. 2021. Special rebranding issue: “Quantitative cell and developmental biology”. Cells and Development. 168(12), 203758.","chicago":"Heisenberg, Carl-Philipp J, Ana Maria Lennon, Roberto Mayor, and Guillaume Salbreux. “Special Rebranding Issue: ‘Quantitative Cell and Developmental Biology.’” <i>Cells and Development</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cdev.2021.203758\">https://doi.org/10.1016/j.cdev.2021.203758</a>.","ieee":"C.-P. J. Heisenberg, A. M. Lennon, R. Mayor, and G. Salbreux, “Special rebranding issue: ‘Quantitative cell and developmental biology,’” <i>Cells and Development</i>, vol. 168, no. 12. Elsevier, 2021.","mla":"Heisenberg, Carl-Philipp J., et al. “Special Rebranding Issue: ‘Quantitative Cell and Developmental Biology.’” <i>Cells and Development</i>, vol. 168, no. 12, 203758, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.cdev.2021.203758\">10.1016/j.cdev.2021.203758</a>.","short":"C.-P.J. Heisenberg, A.M. Lennon, R. Mayor, G. Salbreux, Cells and Development 168 (2021).","apa":"Heisenberg, C.-P. J., Lennon, A. M., Mayor, R., &#38; Salbreux, G. (2021). Special rebranding issue: “Quantitative cell and developmental biology.” <i>Cells and Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cdev.2021.203758\">https://doi.org/10.1016/j.cdev.2021.203758</a>","ama":"Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. Special rebranding issue: “Quantitative cell and developmental biology.” <i>Cells and Development</i>. 2021;168(12). doi:<a href=\"https://doi.org/10.1016/j.cdev.2021.203758\">10.1016/j.cdev.2021.203758</a>"},"article_number":"203758","publication_identifier":{"issn":["2667-2901"]},"type":"journal_article","date_updated":"2026-06-18T08:37:21Z","year":"2021","title":"Special rebranding issue: “Quantitative cell and developmental biology”","corr_author":"1","volume":168,"date_published":"2021-11-17T00:00:00Z","article_type":"letter_note","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1016/j.cdev.2021.203758","month":"11","main_file_link":[{"url":"https://doi.org/10.1016/j.cdev.2021.203758","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"12","pmid":1,"date_created":"2021-11-28T23:01:30Z","day":"17","publication_status":"published","intvolume":"       168","publisher":"Elsevier","department":[{"_id":"CaHe"}],"oa":1,"publication":"Cells and Development","status":"public","ddc":["570"],"external_id":{"isi":["000974771600028"],"pmid":["34800748"]},"quality_controlled":"1","_id":"10366","article_processing_charge":"No","isi":1},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_created":"2021-11-28T23:01:30Z","day":"01","main_file_link":[{"open_access":"1","url":"https://aclanthology.org/2021.acl-tutorials.6/"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publication_status":"published","publication":"59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts","status":"public","publisher":"Association for Computational Linguistics","page":"29-30","department":[{"_id":"HeEd"}],"oa":1,"file":[{"creator":"cchlebak","file_id":"10368","relation":"main_file","access_level":"open_access","date_updated":"2021-11-29T08:41:00Z","content_type":"application/pdf","file_name":"2021_ACL_Ilharco.pdf","date_created":"2021-11-29T08:41:00Z","file_size":1227703,"checksum":"b14052a025a6ecf675bdfe51db98c0d7","success":1}],"article_processing_charge":"No","_id":"10367","acknowledgement":"We would like to thank Abby Schantz, Abe Ittycheriah, Aliaksei Severyn, Allan Heydon, Aly\r\nGrealish, Andrey Vlasov, Arkaitz Zubiaga, Ashwin Kakarla, Chen Sun, Clayton Williams, Cong\r\nYu, Cordelia Schmid, Da-Cheng Juan, Dan Finnie, Dani Valevski, Daniel Rocha, David Price, David Sklar, Devi Krishna, Elena Kochkina, Enrique Alfonseca, Franc¸oise Beaufays, Isabelle Augenstein, Jialu Liu, John Cantwell, John Palowitch, Jordan Boyd-Graber, Lei Shi, Luis Valente, Maria Voitovich, Mehmet Aktuna, Mogan Brown, Mor Naaman, Natalia P, Nidhi Hebbar, Pete Aykroyd, Rahul Sukthankar, Richa Dixit, Steve Pucci, Tania Bedrax-Weiss, Tobias Kaufmann, Tom Boulos, Tu Tsao, Vladimir Chtchetkine, Yair Kurzion, Yifan Xu and Zach Hynes.","ddc":["000"],"quality_controlled":"1","abstract":[{"lang":"eng","text":"How information is created, shared and consumed has changed rapidly in recent decades, in part thanks to new social platforms and technologies on the web. With ever-larger amounts of unstructured and limited labels, organizing and reconciling information from different sources and modalities is a central challenge in machine learning. This cutting-edge tutorial aims to introduce the multimodal entailment task, which can be useful for detecting semantic alignments when a single modality alone does not suffice for a whole content understanding. Starting with a brief overview of natural language processing, computer vision, structured data and neural graph learning, we lay the foundations for the multimodal sections to follow. We then discuss recent multimodal learning literature covering visual, audio and language streams, and explore case studies focusing on tasks which require fine-grained understanding of visual and linguistic semantics question answering, veracity and hatred classification. Finally, we introduce a new dataset for recognizing multimodal entailment, exploring it in a hands-on collaborative section. Overall, this tutorial gives an overview of multimodal learning, introduces a multimodal entailment dataset, and encourages future research in the topic."}],"citation":{"ama":"Ilharco C, Shirazi A, Gopalan A, et al. Recognizing multimodal entailment. In: <i>59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts</i>. Association for Computational Linguistics; 2021:29-30. doi:<a href=\"https://doi.org/10.18653/v1/2021.acl-tutorials.6\">10.18653/v1/2021.acl-tutorials.6</a>","apa":"Ilharco, C., Shirazi, A., Gopalan, A., Nagrani, A., Bratanič, B., Bregler, C., … Imbrasaite, V. (2021). Recognizing multimodal entailment. In <i>59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts</i> (pp. 29–30). Bangkok, Thailand: Association for Computational Linguistics. <a href=\"https://doi.org/10.18653/v1/2021.acl-tutorials.6\">https://doi.org/10.18653/v1/2021.acl-tutorials.6</a>","short":"C. Ilharco, A. Shirazi, A. Gopalan, A. Nagrani, B. Bratanič, C. Bregler, C. Liu, F. Ferreira, G. Barcik, G. Ilharco, G.F. Osang, J. Bulian, J. Frank, L. Smaira, Q. Cao, R. Marino, R. Patel, T. Leung, V. Imbrasaite, in:, 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts, Association for Computational Linguistics, 2021, pp. 29–30.","mla":"Ilharco, Cesar, et al. “Recognizing Multimodal Entailment.” <i>59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts</i>, Association for Computational Linguistics, 2021, pp. 29–30, doi:<a href=\"https://doi.org/10.18653/v1/2021.acl-tutorials.6\">10.18653/v1/2021.acl-tutorials.6</a>.","ieee":"C. Ilharco <i>et al.</i>, “Recognizing multimodal entailment,” in <i>59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts</i>, Bangkok, Thailand, 2021, pp. 29–30.","ista":"Ilharco C, Shirazi A, Gopalan A, Nagrani A, Bratanič B, Bregler C, Liu C, Ferreira F, Barcik G, Ilharco G, Osang GF, Bulian J, Frank J, Smaira L, Cao Q, Marino R, Patel R, Leung T, Imbrasaite V. 2021. Recognizing multimodal entailment. 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts. ACL: Association for Computational Linguistics ; IJCNLP: International Joint Conference on Natural Language Processing, 29–30.","chicago":"Ilharco, Cesar, Afsaneh Shirazi, Arjun Gopalan, Arsha Nagrani, Blaž Bratanič, Chris Bregler, Christina Liu, et al. “Recognizing Multimodal Entailment.” In <i>59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing, Tutorial Abstracts</i>, 29–30. Association for Computational Linguistics, 2021. <a href=\"https://doi.org/10.18653/v1/2021.acl-tutorials.6\">https://doi.org/10.18653/v1/2021.acl-tutorials.6</a>."},"author":[{"last_name":"Ilharco","first_name":"Cesar","full_name":"Ilharco, Cesar"},{"full_name":"Shirazi, Afsaneh","first_name":"Afsaneh","last_name":"Shirazi"},{"full_name":"Gopalan, Arjun","last_name":"Gopalan","first_name":"Arjun"},{"full_name":"Nagrani, Arsha","first_name":"Arsha","last_name":"Nagrani"},{"full_name":"Bratanič, Blaž","last_name":"Bratanič","first_name":"Blaž"},{"first_name":"Chris","last_name":"Bregler","full_name":"Bregler, Chris"},{"last_name":"Liu","first_name":"Christina","full_name":"Liu, Christina"},{"first_name":"Felipe","last_name":"Ferreira","full_name":"Ferreira, Felipe"},{"last_name":"Barcik","first_name":"Gabriek","full_name":"Barcik, Gabriek"},{"first_name":"Gabriel","last_name":"Ilharco","full_name":"Ilharco, Gabriel"},{"full_name":"Osang, Georg F","id":"464B40D6-F248-11E8-B48F-1D18A9856A87","first_name":"Georg F","last_name":"Osang"},{"last_name":"Bulian","first_name":"Jannis","full_name":"Bulian, Jannis"},{"full_name":"Frank, Jared","first_name":"Jared","last_name":"Frank"},{"last_name":"Smaira","first_name":"Lucas","full_name":"Smaira, Lucas"},{"full_name":"Cao, Qin","last_name":"Cao","first_name":"Qin"},{"last_name":"Marino","first_name":"Ricardo","full_name":"Marino, Ricardo"},{"last_name":"Patel","first_name":"Roma","full_name":"Patel, Roma"},{"last_name":"Leung","first_name":"Thomas","full_name":"Leung, Thomas"},{"last_name":"Imbrasaite","first_name":"Vaiva","full_name":"Imbrasaite, Vaiva"}],"conference":{"name":"ACL: Association for Computational Linguistics ; IJCNLP: International Joint Conference on Natural Language Processing","end_date":"2021-08-06","start_date":"2021-08-01","location":"Bangkok, Thailand"},"oa_version":"Published Version","year":"2021","title":"Recognizing multimodal entailment","publication_identifier":{"isbn":["9-781-9540-8557-2"]},"type":"conference","date_updated":"2022-01-26T14:26:36Z","language":[{"iso":"eng"}],"has_accepted_license":"1","file_date_updated":"2021-11-29T08:41:00Z","date_published":"2021-08-01T00:00:00Z","month":"08","doi":"10.18653/v1/2021.acl-tutorials.6","scopus_import":"1"},{"oa_version":"Published Version","author":[{"full_name":"Barfknecht, Rafael E.","last_name":"Barfknecht","first_name":"Rafael E."},{"first_name":"Angela","last_name":"Foerster","full_name":"Foerster, Angela"},{"last_name":"Zinner","first_name":"Nikolaj T.","full_name":"Zinner, Nikolaj T."},{"last_name":"Volosniev","orcid":"0000-0003-0393-5525","first_name":"Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","full_name":"Volosniev, Artem"}],"abstract":[{"text":"Theoretical and experimental studies of the interaction between spins and temperature are vital for the development of spin caloritronics, as they dictate the design of future devices. In this work, we propose a two-terminal cold-atom simulator to study that interaction. The proposed quantum simulator consists of strongly interacting atoms that occupy two temperature reservoirs connected by a one-dimensional link. First, we argue that the dynamics in the link can be described using an inhomogeneous Heisenberg spin chain whose couplings are defined by the local temperature. Second, we show the existence of a spin current in a system with a temperature difference by studying the dynamics that follows the spin-flip of an atom in the link. A temperature gradient accelerates the impurity in one direction more than in the other, leading to an overall spin current similar to the spin Seebeck effect.","lang":"eng"}],"citation":{"ista":"Barfknecht RE, Foerster A, Zinner NT, Volosniev A. 2021. Generation of spin currents by a temperature gradient in a two-terminal device. Communications Physics. 4(1), 252.","chicago":"Barfknecht, Rafael E., Angela Foerster, Nikolaj T. Zinner, and Artem Volosniev. “Generation of Spin Currents by a Temperature Gradient in a Two-Terminal Device.” <i>Communications Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s42005-021-00753-7\">https://doi.org/10.1038/s42005-021-00753-7</a>.","ieee":"R. E. Barfknecht, A. Foerster, N. T. Zinner, and A. Volosniev, “Generation of spin currents by a temperature gradient in a two-terminal device,” <i>Communications Physics</i>, vol. 4, no. 1. Springer Nature, 2021.","mla":"Barfknecht, Rafael E., et al. “Generation of Spin Currents by a Temperature Gradient in a Two-Terminal Device.” <i>Communications Physics</i>, vol. 4, no. 1, 252, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s42005-021-00753-7\">10.1038/s42005-021-00753-7</a>.","short":"R.E. Barfknecht, A. Foerster, N.T. Zinner, A. Volosniev, Communications Physics 4 (2021).","apa":"Barfknecht, R. E., Foerster, A., Zinner, N. T., &#38; Volosniev, A. (2021). Generation of spin currents by a temperature gradient in a two-terminal device. <i>Communications Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42005-021-00753-7\">https://doi.org/10.1038/s42005-021-00753-7</a>","ama":"Barfknecht RE, Foerster A, Zinner NT, Volosniev A. Generation of spin currents by a temperature gradient in a two-terminal device. <i>Communications Physics</i>. 2021;4(1). doi:<a href=\"https://doi.org/10.1038/s42005-021-00753-7\">10.1038/s42005-021-00753-7</a>"},"article_number":"252","date_updated":"2026-04-02T14:05:00Z","publication_identifier":{"eissn":["2399-3650"]},"type":"journal_article","arxiv":1,"title":"Generation of spin currents by a temperature gradient in a two-terminal device","year":"2021","date_published":"2021-11-26T00:00:00Z","volume":4,"ec_funded":1,"has_accepted_license":"1","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"file_date_updated":"2021-12-06T14:53:41Z","language":[{"iso":"eng"}],"article_type":"original","scopus_import":"1","month":"11","doi":"10.1038/s42005-021-00753-7","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2021-12-05T23:01:39Z","day":"26","issue":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"intvolume":"         4","publication_status":"published","oa":1,"file":[{"success":1,"file_name":"2021_NatComm_Barfknecht.pdf","file_size":1068984,"date_created":"2021-12-06T14:53:41Z","checksum":"9097319952cb9a3d96e7fd3aa9813a03","access_level":"open_access","date_updated":"2021-12-06T14:53:41Z","content_type":"application/pdf","creator":"alisjak","file_id":"10420","relation":"main_file"}],"publisher":"Springer Nature","department":[{"_id":"MiLe"}],"publication":"Communications Physics","status":"public","ddc":["530"],"quality_controlled":"1","external_id":{"isi":["000722867600002"],"arxiv":["2101.02020"]},"acknowledgement":"The authors acknowledge support from the European QuantERA ERA-NET Cofund in Quantum Technologies (Project QTFLAG Grant Agreement No. 731473) (R.E.B), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) Brazil (A.F.), the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (A.G.V.), the Independent Research Fund Denmark, the Carlsberg Foundation, and Aarhus University Research Foundation under the Jens Christian Skou fellowship program (N.T.Z).","_id":"10401","article_processing_charge":"No","isi":1},{"acknowledgement":"We thank all members of our respective groups for helpful discussion on the paper. The authors are also grateful to Prof. Abdel El. Manira for support and sharing Tg(HUC:Gal4;UAS:Synaptohysin-GFP), to Haohao Wu for discussion, and thank Elena Zabalueva for the zebrafish schematic. The authors also acknowledge Zebrafish core facility, Genome Engineering Zebrafish and Biomedicum Imaging Core from the Karolinska Institutet for technical support. This work received funding from the ERC under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 851288 to E.H.) and under the Marie Skłodowska-Curie grant agreement No. 754411 (to M.C.U.); Swedish Research Council (to F.L., I.A. and S.H.); Knut and Alice Wallenberg Foundation (F.L. and I.A.); Swedish Brain Foundation (F.L. and S.H.); Ming Wai Lau Foundation (to F.L.); StratRegen (to F.L.); ERC Consolidator grant STEMMING-FROM-NERVE and ERC Synergy Grant KILL-OR-DIFFERENTIATE (to I.A.); Bertil Hallsten Research Foundation (to I.A.); Cancerfonden (to I.A.); the Paradifference Foundation (to I.A.); Austrian Science Fund (to I.A.); and StratNeuro (to S.H.).","isi":1,"article_processing_charge":"No","_id":"10402","quality_controlled":"1","external_id":{"pmid":["34819507"],"isi":["000722322900020"]},"ddc":["573"],"status":"public","publication":"Nature Communications","oa":1,"file":[{"success":1,"file_size":2303405,"date_created":"2021-12-10T08:54:09Z","checksum":"63c56ec75314a71e63e7dd2920b3c5b5","file_name":"2021_NatComm_Ucar.pdf","date_updated":"2021-12-10T08:54:09Z","content_type":"application/pdf","access_level":"open_access","creator":"cchlebak","file_id":"10529","relation":"main_file"}],"department":[{"_id":"EdHa"}],"publisher":"Springer Nature","intvolume":"        12","publication_status":"published","day":"24","date_created":"2021-12-05T23:01:40Z","pmid":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1038/s41467-021-27135-5","month":"11","scopus_import":"1","language":[{"iso":"eng"}],"article_type":"original","ec_funded":1,"date_published":"2021-11-24T00:00:00Z","volume":12,"file_date_updated":"2021-12-10T08:54:09Z","project":[{"name":"Design Principles of Branching Morphogenesis","_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","call_identifier":"H2020"},{"call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"}],"has_accepted_license":"1","title":"Theory of branching morphogenesis by local interactions and global guidance","related_material":{"record":[{"relation":"research_data","status":"public","id":"13058"}]},"year":"2021","date_updated":"2025-04-14T07:43:47Z","type":"journal_article","publication_identifier":{"eissn":["2041-1723"]},"citation":{"chicago":"Ucar, Mehmet C, Dmitrii Kamenev, Kazunori Sunadome, Dominik C Fachet, Francois Lallemend, Igor Adameyko, Saida Hadjab, and Edouard B Hannezo. “Theory of Branching Morphogenesis by Local Interactions and Global Guidance.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-27135-5\">https://doi.org/10.1038/s41467-021-27135-5</a>.","ista":"Ucar MC, Kamenev D, Sunadome K, Fachet DC, Lallemend F, Adameyko I, Hadjab S, Hannezo EB. 2021. Theory of branching morphogenesis by local interactions and global guidance. Nature Communications. 12, 6830.","ieee":"M. C. Ucar <i>et al.</i>, “Theory of branching morphogenesis by local interactions and global guidance,” <i>Nature Communications</i>, vol. 12. Springer Nature, 2021.","mla":"Ucar, Mehmet C., et al. “Theory of Branching Morphogenesis by Local Interactions and Global Guidance.” <i>Nature Communications</i>, vol. 12, 6830, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-27135-5\">10.1038/s41467-021-27135-5</a>.","short":"M.C. Ucar, D. Kamenev, K. Sunadome, D.C. Fachet, F. Lallemend, I. Adameyko, S. Hadjab, E.B. Hannezo, Nature Communications 12 (2021).","apa":"Ucar, M. C., Kamenev, D., Sunadome, K., Fachet, D. C., Lallemend, F., Adameyko, I., … Hannezo, E. B. (2021). Theory of branching morphogenesis by local interactions and global guidance. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-27135-5\">https://doi.org/10.1038/s41467-021-27135-5</a>","ama":"Ucar MC, Kamenev D, Sunadome K, et al. Theory of branching morphogenesis by local interactions and global guidance. <i>Nature Communications</i>. 2021;12. doi:<a href=\"https://doi.org/10.1038/s41467-021-27135-5\">10.1038/s41467-021-27135-5</a>"},"article_number":"6830","abstract":[{"lang":"eng","text":"Branching morphogenesis governs the formation of many organs such as lung, kidney, and the neurovascular system. Many studies have explored system-specific molecular and cellular regulatory mechanisms, as well as self-organizing rules underlying branching morphogenesis. However, in addition to local cues, branched tissue growth can also be influenced by global guidance. Here, we develop a theoretical framework for a stochastic self-organized branching process in the presence of external cues. Combining analytical theory with numerical simulations, we predict differential signatures of global vs. local regulatory mechanisms on the branching pattern, such as angle distributions, domain size, and space-filling efficiency. We find that branch alignment follows a generic scaling law determined by the strength of global guidance, while local interactions influence the tissue density but not its overall territory. Finally, using zebrafish innervation as a model system, we test these key features of the model experimentally. Our work thus provides quantitative predictions to disentangle the role of different types of cues in shaping branched structures across scales."}],"oa_version":"Published Version","author":[{"first_name":"Mehmet C","orcid":"0000-0003-0506-4217","last_name":"Ucar","full_name":"Ucar, Mehmet C","id":"50B2A802-6007-11E9-A42B-EB23E6697425"},{"full_name":"Kamenev, Dmitrii","last_name":"Kamenev","first_name":"Dmitrii"},{"last_name":"Sunadome","first_name":"Kazunori","full_name":"Sunadome, Kazunori"},{"full_name":"Fachet, Dominik C","id":"14FDD550-AA41-11E9-A0E5-1ACCE5697425","first_name":"Dominik C","last_name":"Fachet"},{"last_name":"Lallemend","first_name":"Francois","full_name":"Lallemend, Francois"},{"full_name":"Adameyko, Igor","first_name":"Igor","last_name":"Adameyko"},{"first_name":"Saida","last_name":"Hadjab","full_name":"Hadjab, Saida"},{"full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo"}]},{"month":"11","doi":"10.7554/eLife.65954","scopus_import":"1","language":[{"iso":"eng"}],"article_type":"original","volume":10,"date_published":"2021-11-03T00:00:00Z","has_accepted_license":"1","file_date_updated":"2021-12-10T08:31:41Z","title":"Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons","year":"2021","date_updated":"2025-03-07T08:12:39Z","type":"journal_article","publication_identifier":{"eissn":["2050-084X"]},"article_number":"e65954","citation":{"short":"C. Biane, F. Rückerl, T. Abrahamsson, C. Saint-Cloment, J. Mariani, R. Shigemoto, D.A. Digregorio, R.M. Sherrard, L. Cathala, ELife 10 (2021).","chicago":"Biane, Celia, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A. Digregorio, Rachel M. Sherrard, and Laurence Cathala. “Developmental Emergence of Two-Stage Nonlinear Synaptic Integration in Cerebellar Interneurons.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/eLife.65954\">https://doi.org/10.7554/eLife.65954</a>.","ista":"Biane C, Rückerl F, Abrahamsson T, Saint-Cloment C, Mariani J, Shigemoto R, Digregorio DA, Sherrard RM, Cathala L. 2021. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. eLife. 10, e65954.","mla":"Biane, Celia, et al. “Developmental Emergence of Two-Stage Nonlinear Synaptic Integration in Cerebellar Interneurons.” <i>ELife</i>, vol. 10, e65954, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/eLife.65954\">10.7554/eLife.65954</a>.","ieee":"C. Biane <i>et al.</i>, “Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021.","ama":"Biane C, Rückerl F, Abrahamsson T, et al. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/eLife.65954\">10.7554/eLife.65954</a>","apa":"Biane, C., Rückerl, F., Abrahamsson, T., Saint-Cloment, C., Mariani, J., Shigemoto, R., … Cathala, L. (2021). Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.65954\">https://doi.org/10.7554/eLife.65954</a>"},"abstract":[{"text":"Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that postnatal maturation of postsynaptic strength was homogeneously reduced along the somatodendritic axis, but dendritic integration was always sublinear. However, dendritic branching increased without changes in synapse density, leading to a substantial gain in distal inputs. Thus, changes in synapse distribution, rather than dendrite cable properties, are the dominant mechanism underlying the maturation of neuronal computation. These mechanisms favor the emergence of a spatially compartmentalized two-stage integration model promoting location-dependent integration within dendritic subunits.","lang":"eng"}],"oa_version":"Published Version","author":[{"full_name":"Biane, Celia","first_name":"Celia","last_name":"Biane"},{"full_name":"Rückerl, Florian","last_name":"Rückerl","first_name":"Florian"},{"full_name":"Abrahamsson, Therese","last_name":"Abrahamsson","first_name":"Therese"},{"last_name":"Saint-Cloment","first_name":"Cécile","full_name":"Saint-Cloment, Cécile"},{"first_name":"Jean","last_name":"Mariani","full_name":"Mariani, Jean"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Digregorio, David A.","first_name":"David A.","last_name":"Digregorio"},{"last_name":"Sherrard","first_name":"Rachel M.","full_name":"Sherrard, Rachel M."},{"full_name":"Cathala, Laurence","last_name":"Cathala","first_name":"Laurence"}],"acknowledgement":"This study was supported by the Centre National de la Recherche Scientifique and the Agence Nationale de la Recherche (ANR-13-BSV4-00166, to LC and DAD). TA was supported by fellowships from the Fondation pour la Recherche Medicale and the Swedish Research Council. We thank Dmitry Ershov from the Image Analysis Hub of the Institut Pasteur, Elodie Le Monnier, Elena Hollergschwandtner, Vanessa Zheden, and Corinne Nantet for technical support and Haining Zhong for providing the Venus-tagged PSD95 mouse line. We would like to thank Alberto Bacci, Ann Lohof, and Nelson Rebola for comments on the manuscript.","isi":1,"article_processing_charge":"No","_id":"10403","quality_controlled":"1","external_id":{"isi":["000715789500001"],"pmid":["34730085"]},"ddc":["570"],"status":"public","publication":"eLife","oa":1,"file":[{"success":1,"file_name":"2021_eLife_Biane.pdf","date_created":"2021-12-10T08:31:41Z","file_size":13131322,"checksum":"c7c33c3319428d56e332e22349c50ed3","access_level":"open_access","content_type":"application/pdf","date_updated":"2021-12-10T08:31:41Z","creator":"cchlebak","file_id":"10528","relation":"main_file"}],"department":[{"_id":"RySh"}],"publisher":"eLife Sciences Publications","intvolume":"        10","publication_status":"published","day":"03","date_created":"2021-12-05T23:01:40Z","pmid":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2110.07667"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"7","date_created":"2021-12-05T23:01:40Z","day":"27","publication_status":"published","intvolume":"        40","publisher":"Wiley","department":[{"_id":"ToHe"}],"page":"253-264","oa":1,"publication":"Computer Graphics Forum","status":"public","quality_controlled":"1","external_id":{"isi":["000722952000024"],"arxiv":["2110.07667"]},"_id":"10404","article_processing_charge":"No","isi":1,"acknowledgement":"We thank Robert Geirhos and Roland Zimmermann for their participation in the case study and valuable feedback, Chris Olah and Nick Cammarata for valuable discussions in the early phase of the project, as well as the Distill Slack workspace as a platform for discussions. M.L. is supported in part by the Austrian Science Fund (FWF) under grant Z211-N23 (Wittgenstein Award). J.B. is supported by the German Federal Ministry of Education and Research\r\n(BMBF) through the Competence Center for Machine Learning (TUE.AI, FKZ 01IS18039A) and the International Max Planck Research School for Intelligent Systems (IMPRS-IS). R.H. is partially supported by Boeing and Horizon-2020 ECSEL (grant 783163, iDev40).\r\n","author":[{"full_name":"Sietzen, Stefan","last_name":"Sietzen","first_name":"Stefan"},{"last_name":"Lechner","first_name":"Mathias","id":"3DC22916-F248-11E8-B48F-1D18A9856A87","full_name":"Lechner, Mathias"},{"last_name":"Borowski","first_name":"Judy","full_name":"Borowski, Judy"},{"first_name":"Ramin","last_name":"Hasani","full_name":"Hasani, Ramin"},{"last_name":"Waldner","first_name":"Manuela","full_name":"Waldner, Manuela"}],"oa_version":"Preprint","abstract":[{"text":"While convolutional neural networks (CNNs) have found wide adoption as state-of-the-art models for image-related tasks, their predictions are often highly sensitive to small input perturbations, which the human vision is robust against. This paper presents Perturber, a web-based application that allows users to instantaneously explore how CNN activations and predictions evolve when a 3D input scene is interactively perturbed. Perturber offers a large variety of scene modifications, such as camera controls, lighting and shading effects, background modifications, object morphing, as well as adversarial attacks, to facilitate the discovery of potential vulnerabilities. Fine-tuned model versions can be directly compared for qualitative evaluation of their robustness. Case studies with machine learning experts have shown that Perturber helps users to quickly generate hypotheses about model vulnerabilities and to qualitatively compare model behavior. Using quantitative analyses, we could replicate users’ insights with other CNN architectures and input images, yielding new insights about the vulnerability of adversarially trained models.","lang":"eng"}],"citation":{"apa":"Sietzen, S., Lechner, M., Borowski, J., Hasani, R., &#38; Waldner, M. (2021). Interactive analysis of CNN robustness. <i>Computer Graphics Forum</i>. Wiley. <a href=\"https://doi.org/10.1111/cgf.14418\">https://doi.org/10.1111/cgf.14418</a>","ama":"Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. Interactive analysis of CNN robustness. <i>Computer Graphics Forum</i>. 2021;40(7):253-264. doi:<a href=\"https://doi.org/10.1111/cgf.14418\">10.1111/cgf.14418</a>","ieee":"S. Sietzen, M. Lechner, J. Borowski, R. Hasani, and M. Waldner, “Interactive analysis of CNN robustness,” <i>Computer Graphics Forum</i>, vol. 40, no. 7. Wiley, pp. 253–264, 2021.","mla":"Sietzen, Stefan, et al. “Interactive Analysis of CNN Robustness.” <i>Computer Graphics Forum</i>, vol. 40, no. 7, Wiley, 2021, pp. 253–64, doi:<a href=\"https://doi.org/10.1111/cgf.14418\">10.1111/cgf.14418</a>.","chicago":"Sietzen, Stefan, Mathias Lechner, Judy Borowski, Ramin Hasani, and Manuela Waldner. “Interactive Analysis of CNN Robustness.” <i>Computer Graphics Forum</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/cgf.14418\">https://doi.org/10.1111/cgf.14418</a>.","ista":"Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. 2021. Interactive analysis of CNN robustness. Computer Graphics Forum. 40(7), 253–264.","short":"S. Sietzen, M. Lechner, J. Borowski, R. Hasani, M. Waldner, Computer Graphics Forum 40 (2021) 253–264."},"publication_identifier":{"eissn":["1467-8659"],"issn":["0167-7055"]},"type":"journal_article","arxiv":1,"date_updated":"2025-04-15T06:25:55Z","year":"2021","title":"Interactive analysis of CNN robustness","project":[{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems","call_identifier":"FWF"}],"date_published":"2021-11-27T00:00:00Z","volume":40,"article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","month":"11","doi":"10.1111/cgf.14418"},{"department":[{"_id":"CaHe"}],"page":"209-233","publisher":"Annual Reviews","oa":1,"OA_place":"publisher","status":"public","publication":"Annual Review of Genetics","external_id":{"pmid":["34460295"],"isi":["000747220900010"]},"quality_controlled":"1","ddc":["570"],"isi":1,"OA_type":"free access","_id":"10406","article_processing_charge":"No","acknowledgement":"The authors would like to thank Feyza Nur Arslan, Suyash Naik, Diana Pinheiro, Alexandra Schauer, and Shayan Shamipour for their comments on the draft. N.M. is supported by an ISTplus postdoctoral fellowship (H2020 Marie-Sklodowska-Curie COFUND Action).","main_file_link":[{"url":"https://doi.org/10.1146/annurev-genet-071819-103748","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-12-05T23:01:41Z","day":"30","pmid":1,"publication_status":"published","keyword":["morphogenesis","forward genetics","high-resolution microscopy","biophysics","biochemistry","patterning"],"intvolume":"        55","corr_author":"1","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"ec_funded":1,"volume":55,"date_published":"2021-08-30T00:00:00Z","article_type":"original","language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1146/annurev-genet-071819-103748","month":"08","author":[{"id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","full_name":"Mishra, Nikhil","last_name":"Mishra","orcid":"0000-0002-6425-5788","first_name":"Nikhil"},{"first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"oa_version":"Published Version","citation":{"ama":"Mishra N, Heisenberg C-PJ. Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. 2021;55:209-233. doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>","apa":"Mishra, N., &#38; Heisenberg, C.-P. J. (2021). Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>","short":"N. Mishra, C.-P.J. Heisenberg, Annual Review of Genetics 55 (2021) 209–233.","mla":"Mishra, Nikhil, and Carl-Philipp J. Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>, vol. 55, Annual Reviews, 2021, pp. 209–33, doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>.","ieee":"N. Mishra and C.-P. J. Heisenberg, “Dissecting organismal morphogenesis by bridging genetics and biophysics,” <i>Annual Review of Genetics</i>, vol. 55. Annual Reviews, pp. 209–233, 2021.","chicago":"Mishra, Nikhil, and Carl-Philipp J Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>. Annual Reviews, 2021. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>.","ista":"Mishra N, Heisenberg C-PJ. 2021. Dissecting organismal morphogenesis by bridging genetics and biophysics. Annual Review of Genetics. 55, 209–233."},"abstract":[{"lang":"eng","text":"Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to such an inquiry in the future."}],"type":"journal_article","publication_identifier":{"eissn":["1545-2948"],"issn":["0066-4197"]},"date_updated":"2026-06-18T08:39:48Z","year":"2021","title":"Dissecting organismal morphogenesis by bridging genetics and biophysics"},{"title":"Trojan-resilience without cryptography","year":"2021","date_updated":"2025-04-14T07:22:05Z","type":"conference","publication_identifier":{"eissn":["1611-3349"],"isbn":["9-783-0309-0452-4"],"issn":["0302-9743"]},"citation":{"short":"S. Chakraborty, S. Dziembowski, M. Gałązka, T. Lizurej, K.Z. Pietrzak, M.X. Yeo, in:, Springer Nature, 2021, pp. 397–428.","chicago":"Chakraborty, Suvradip, Stefan Dziembowski, Małgorzata Gałązka, Tomasz Lizurej, Krzysztof Z Pietrzak, and Michelle X Yeo. “Trojan-Resilience without Cryptography,” 13043:397–428. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-90453-1_14\">https://doi.org/10.1007/978-3-030-90453-1_14</a>.","ista":"Chakraborty S, Dziembowski S, Gałązka M, Lizurej T, Pietrzak KZ, Yeo MX. 2021. Trojan-resilience without cryptography. TCC: Theory of Cryptography Conference, LNCS, vol. 13043, 397–428.","mla":"Chakraborty, Suvradip, et al. <i>Trojan-Resilience without Cryptography</i>. Vol. 13043, Springer Nature, 2021, pp. 397–428, doi:<a href=\"https://doi.org/10.1007/978-3-030-90453-1_14\">10.1007/978-3-030-90453-1_14</a>.","ieee":"S. Chakraborty, S. Dziembowski, M. Gałązka, T. Lizurej, K. Z. Pietrzak, and M. X. Yeo, “Trojan-resilience without cryptography,” presented at the TCC: Theory of Cryptography Conference, Raleigh, NC, United States, 2021, vol. 13043, pp. 397–428.","ama":"Chakraborty S, Dziembowski S, Gałązka M, Lizurej T, Pietrzak KZ, Yeo MX. Trojan-resilience without cryptography. In: Vol 13043. Springer Nature; 2021:397-428. doi:<a href=\"https://doi.org/10.1007/978-3-030-90453-1_14\">10.1007/978-3-030-90453-1_14</a>","apa":"Chakraborty, S., Dziembowski, S., Gałązka, M., Lizurej, T., Pietrzak, K. Z., &#38; Yeo, M. X. (2021). Trojan-resilience without cryptography (Vol. 13043, pp. 397–428). Presented at the TCC: Theory of Cryptography Conference, Raleigh, NC, United States: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-90453-1_14\">https://doi.org/10.1007/978-3-030-90453-1_14</a>"},"abstract":[{"text":"Digital hardware Trojans are integrated circuits whose implementation differ from the specification in an arbitrary and malicious way. For example, the circuit can differ from its specified input/output behavior after some fixed number of queries (known as “time bombs”) or on some particular input (known as “cheat codes”). To detect such Trojans, countermeasures using multiparty computation (MPC) or verifiable computation (VC) have been proposed. On a high level, to realize a circuit with specification   F  one has more sophisticated circuits   F⋄  manufactured (where   F⋄  specifies a MPC or VC of   F ), and then embeds these   F⋄ ’s into a master circuit which must be trusted but is relatively simple compared to   F . Those solutions impose a significant overhead as   F⋄  is much more complex than   F , also the master circuits are not exactly trivial. In this work, we show that in restricted settings, where   F  has no evolving state and is queried on independent inputs, we can achieve a relaxed security notion using very simple constructions. In particular, we do not change the specification of the circuit at all (i.e.,   F=F⋄ ). Moreover the master circuit basically just queries a subset of its manufactured circuits and checks if they’re all the same. The security we achieve guarantees that, if the manufactured circuits are initially tested on up to T inputs, the master circuit will catch Trojans that try to deviate on significantly more than a 1/T fraction of the inputs. This bound is optimal for the type of construction considered, and we provably achieve it using a construction where 12 instantiations of   F  need to be embedded into the master. We also discuss an extremely simple construction with just 2 instantiations for which we conjecture that it already achieves the optimal bound.","lang":"eng"}],"conference":{"location":"Raleigh, NC, United States","start_date":"2021-11-08","end_date":"2021-11-11","name":"TCC: Theory of Cryptography Conference"},"oa_version":"Preprint","author":[{"id":"B9CD0494-D033-11E9-B219-A439E6697425","full_name":"Chakraborty, Suvradip","last_name":"Chakraborty","first_name":"Suvradip"},{"first_name":"Stefan","last_name":"Dziembowski","full_name":"Dziembowski, Stefan"},{"last_name":"Gałązka","first_name":"Małgorzata","full_name":"Gałązka, Małgorzata"},{"last_name":"Lizurej","first_name":"Tomasz","full_name":"Lizurej, Tomasz"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","first_name":"Krzysztof Z","orcid":"0000-0002-9139-1654"},{"orcid":"0009-0001-3676-4809","first_name":"Michelle X","last_name":"Yeo","full_name":"Yeo, Michelle X","id":"2D82B818-F248-11E8-B48F-1D18A9856A87"}],"month":"11","doi":"10.1007/978-3-030-90453-1_14","scopus_import":"1","language":[{"iso":"eng"}],"ec_funded":1,"volume":13043,"date_published":"2021-11-04T00:00:00Z","project":[{"grant_number":"682815","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","name":"Teaching Old Crypto New Tricks","call_identifier":"H2020"}],"intvolume":"     13043","publication_status":"published","day":"04","date_created":"2021-12-05T23:01:42Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","main_file_link":[{"url":"https://eprint.iacr.org/2021/1224","open_access":"1"}],"isi":1,"article_processing_charge":"No","_id":"10407","quality_controlled":"1","external_id":{"isi":["000728364000014"]},"alternative_title":["LNCS"],"status":"public","oa":1,"page":"397-428","department":[{"_id":"KrPi"}],"publisher":"Springer Nature"},{"main_file_link":[{"url":"https://eprint.iacr.org/2021/1158","open_access":"1"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","day":"04","date_created":"2021-12-05T23:01:42Z","publication_status":"published","intvolume":"     13044","publisher":"Springer Nature","page":"222-253","department":[{"_id":"KrPi"}],"oa":1,"publication":"19th International Conference","alternative_title":["LNCS"],"status":"public","external_id":{"isi":["000728363700008"]},"quality_controlled":"1","_id":"10408","article_processing_charge":"No","isi":1,"acknowledgement":"B. Auerbach, M.A. Baig and K. Pietrzak—received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (682815 - TOCNeT); Karen Klein was supported in part by ERC CoG grant 724307 and conducted part of this work at IST Austria, funded by the ERC under the European Union’s Horizon 2020 research and innovation programme (682815 - TOCNeT); Guillermo Pascual-Perez was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385; Michael Walter conducted part of this work at IST Austria, funded by the ERC under the European Union’s Horizon 2020 research and innovation programme (682815 - TOCNeT).","author":[{"last_name":"Alwen","first_name":"Joel F","id":"2A8DFA8C-F248-11E8-B48F-1D18A9856A87","full_name":"Alwen, Joel F"},{"id":"D33D2B18-E445-11E9-ABB7-15F4E5697425","full_name":"Auerbach, Benedikt","last_name":"Auerbach","orcid":"0000-0002-7553-6606","first_name":"Benedikt"},{"id":"3EDE6DE4-AA5A-11E9-986D-341CE6697425","full_name":"Baig, Mirza Ahad","last_name":"Baig","first_name":"Mirza Ahad"},{"full_name":"Cueto Noval, Miguel","id":"ffc563a3-f6e0-11ea-865d-e3cce03d17cc","first_name":"Miguel","orcid":"0000-0002-2505-4246","last_name":"Cueto Noval"},{"id":"3E83A2F8-F248-11E8-B48F-1D18A9856A87","full_name":"Klein, Karen","last_name":"Klein","first_name":"Karen"},{"full_name":"Pascual Perez, Guillermo","id":"2D7ABD02-F248-11E8-B48F-1D18A9856A87","first_name":"Guillermo","orcid":"0000-0001-8630-415X","last_name":"Pascual Perez"},{"first_name":"Krzysztof Z","orcid":"0000-0002-9139-1654","last_name":"Pietrzak","full_name":"Pietrzak, Krzysztof Z","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Walter","orcid":"0000-0003-3186-2482","first_name":"Michael","id":"488F98B0-F248-11E8-B48F-1D18A9856A87","full_name":"Walter, Michael"}],"oa_version":"Preprint","conference":{"name":"TCC: Theory of Cryptography","location":"Raleigh, NC, United States","start_date":"2021-11-08","end_date":"2021-11-11"},"abstract":[{"text":"Key trees are often the best solution in terms of transmission cost and storage requirements for managing keys in a setting where a group needs to share a secret key, while being able to efficiently rotate the key material of users (in order to recover from a potential compromise, or to add or remove users). Applications include multicast encryption protocols like LKH (Logical Key Hierarchies) or group messaging like the current IETF proposal TreeKEM. A key tree is a (typically balanced) binary tree, where each node is identified with a key: leaf nodes hold users’ secret keys while the root is the shared group key. For a group of size N, each user just holds   log(N)  keys (the keys on the path from its leaf to the root) and its entire key material can be rotated by broadcasting   2log(N)  ciphertexts (encrypting each fresh key on the path under the keys of its parents). In this work we consider the natural setting where we have many groups with partially overlapping sets of users, and ask if we can find solutions where the cost of rotating a key is better than in the trivial one where we have a separate key tree for each group. We show that in an asymptotic setting (where the number m of groups is fixed while the number N of users grows) there exist more general key graphs whose cost converges to the cost of a single group, thus saving a factor linear in the number of groups over the trivial solution. As our asymptotic “solution” converges very slowly and performs poorly on concrete examples, we propose an algorithm that uses a natural heuristic to compute a key graph for any given group structure. Our algorithm combines two greedy algorithms, and is thus very efficient: it first converts the group structure into a “lattice graph”, which is then turned into a key graph by repeatedly applying the algorithm for constructing a Huffman code. To better understand how far our proposal is from an optimal solution, we prove lower bounds on the update cost of continuous group-key agreement and multicast encryption in a symbolic model admitting (asymmetric) encryption, pseudorandom generators, and secret sharing as building blocks.","lang":"eng"}],"citation":{"apa":"Alwen, J. F., Auerbach, B., Baig, M. A., Cueto Noval, M., Klein, K., Pascual Perez, G., … Walter, M. (2021). Grafting key trees: Efficient key management for overlapping groups. In <i>19th International Conference</i> (Vol. 13044, pp. 222–253). Raleigh, NC, United States: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-90456-2_8\">https://doi.org/10.1007/978-3-030-90456-2_8</a>","ama":"Alwen JF, Auerbach B, Baig MA, et al. Grafting key trees: Efficient key management for overlapping groups. In: <i>19th International Conference</i>. Vol 13044. Springer Nature; 2021:222-253. doi:<a href=\"https://doi.org/10.1007/978-3-030-90456-2_8\">10.1007/978-3-030-90456-2_8</a>","mla":"Alwen, Joel F., et al. “Grafting Key Trees: Efficient Key Management for Overlapping Groups.” <i>19th International Conference</i>, vol. 13044, Springer Nature, 2021, pp. 222–53, doi:<a href=\"https://doi.org/10.1007/978-3-030-90456-2_8\">10.1007/978-3-030-90456-2_8</a>.","ieee":"J. F. Alwen <i>et al.</i>, “Grafting key trees: Efficient key management for overlapping groups,” in <i>19th International Conference</i>, Raleigh, NC, United States, 2021, vol. 13044, pp. 222–253.","ista":"Alwen JF, Auerbach B, Baig MA, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ, Walter M. 2021. Grafting key trees: Efficient key management for overlapping groups. 19th International Conference. TCC: Theory of Cryptography, LNCS, vol. 13044, 222–253.","chicago":"Alwen, Joel F, Benedikt Auerbach, Mirza Ahad Baig, Miguel Cueto Noval, Karen Klein, Guillermo Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “Grafting Key Trees: Efficient Key Management for Overlapping Groups.” In <i>19th International Conference</i>, 13044:222–53. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-90456-2_8\">https://doi.org/10.1007/978-3-030-90456-2_8</a>.","short":"J.F. Alwen, B. Auerbach, M.A. Baig, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak, M. Walter, in:, 19th International Conference, Springer Nature, 2021, pp. 222–253."},"publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9-783-0309-0455-5"],"eisbn":["978-3-030-90456-2"]},"type":"conference","date_updated":"2026-04-07T13:01:26Z","year":"2021","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"18088"}]},"title":"Grafting key trees: Efficient key management for overlapping groups","project":[{"name":"Teaching Old Crypto New Tricks","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","grant_number":"682815","call_identifier":"H2020"},{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"volume":13044,"date_published":"2021-11-04T00:00:00Z","ec_funded":1,"language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1007/978-3-030-90456-2_8","month":"11"},{"ec_funded":1,"volume":13047,"date_published":"2021-11-10T00:00:00Z","project":[{"call_identifier":"H2020","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","grant_number":"863818","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"}],"language":[{"iso":"eng"}],"scopus_import":"1","doi":"10.1007/978-3-030-90870-6_33","month":"11","conference":{"end_date":"2021-11-26","location":"Virtual","start_date":"2021-11-20","name":"FM: Formal Methods"},"oa_version":"Preprint","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X"},{"first_name":"Ehsan","orcid":"0000-0002-8595-0587","last_name":"Kafshdar Goharshadi","full_name":"Kafshdar Goharshadi, Ehsan","id":"103b4fa0-896a-11ed-bdf8-87b697bef40d"},{"full_name":"Novotný, Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","first_name":"Petr","last_name":"Novotný"},{"full_name":"Zárevúcky, Jiří","last_name":"Zárevúcky","first_name":"Jiří"},{"full_name":"Zikelic, Dorde","id":"294AA7A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4681-1699","first_name":"Dorde","last_name":"Zikelic"}],"citation":{"apa":"Chatterjee, K., Goharshady, E., Novotný, P., Zárevúcky, J., &#38; Zikelic, D. (2021). On lexicographic proof rules for probabilistic termination. In <i>24th International Symposium on Formal Methods</i> (Vol. 13047, pp. 619–639). Virtual: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-90870-6_33\">https://doi.org/10.1007/978-3-030-90870-6_33</a>","ama":"Chatterjee K, Goharshady E, Novotný P, Zárevúcky J, Zikelic D. On lexicographic proof rules for probabilistic termination. In: <i>24th International Symposium on Formal Methods</i>. Vol 13047. Springer Nature; 2021:619-639. doi:<a href=\"https://doi.org/10.1007/978-3-030-90870-6_33\">10.1007/978-3-030-90870-6_33</a>","mla":"Chatterjee, Krishnendu, et al. “On Lexicographic Proof Rules for Probabilistic Termination.” <i>24th International Symposium on Formal Methods</i>, vol. 13047, Springer Nature, 2021, pp. 619–39, doi:<a href=\"https://doi.org/10.1007/978-3-030-90870-6_33\">10.1007/978-3-030-90870-6_33</a>.","ieee":"K. Chatterjee, E. Goharshady, P. Novotný, J. Zárevúcky, and D. Zikelic, “On lexicographic proof rules for probabilistic termination,” in <i>24th International Symposium on Formal Methods</i>, Virtual, 2021, vol. 13047, pp. 619–639.","chicago":"Chatterjee, Krishnendu, Ehsan Goharshady, Petr Novotný, Jiří Zárevúcky, and Dorde Zikelic. “On Lexicographic Proof Rules for Probabilistic Termination.” In <i>24th International Symposium on Formal Methods</i>, 13047:619–39. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-90870-6_33\">https://doi.org/10.1007/978-3-030-90870-6_33</a>.","ista":"Chatterjee K, Goharshady E, Novotný P, Zárevúcky J, Zikelic D. 2021. On lexicographic proof rules for probabilistic termination. 24th International Symposium on Formal Methods. FM: Formal Methods, LNCS, vol. 13047, 619–639.","short":"K. Chatterjee, E. Goharshady, P. Novotný, J. Zárevúcky, D. Zikelic, in:, 24th International Symposium on Formal Methods, Springer Nature, 2021, pp. 619–639."},"abstract":[{"lang":"eng","text":"We consider the almost-sure (a.s.) termination problem for probabilistic programs, which are a stochastic extension of classical imperative programs. Lexicographic ranking functions provide a sound and practical approach for termination of non-probabilistic programs, and their extension to probabilistic programs is achieved via lexicographic ranking supermartingales (LexRSMs). However, LexRSMs introduced in the previous work have a limitation that impedes their automation: all of their components have to be non-negative in all reachable states. This might result in LexRSM not existing even for simple terminating programs. Our contributions are twofold: First, we introduce a generalization of LexRSMs which allows for some components to be negative. This standard feature of non-probabilistic termination proofs was hitherto not known to be sound in the probabilistic setting, as the soundness proof requires a careful analysis of the underlying stochastic process. Second, we present polynomial-time algorithms using our generalized LexRSMs for proving a.s. termination in broad classes of linear-arithmetic programs."}],"date_updated":"2026-04-07T13:27:55Z","arxiv":1,"type":"conference","publication_identifier":{"eisbn":["978-3-030-90870-6"],"isbn":["9-783-0309-0869-0"],"eissn":["1611-3349"],"issn":["0302-9743"]},"title":"On lexicographic proof rules for probabilistic termination","related_material":{"record":[{"id":"14778","status":"public","relation":"later_version"},{"id":"14539","relation":"dissertation_contains","status":"public"}]},"year":"2021","oa":1,"department":[{"_id":"KrCh"}],"page":"619-639","publisher":"Springer Nature","status":"public","alternative_title":["LNCS"],"publication":"24th International Symposium on Formal Methods","quality_controlled":"1","external_id":{"arxiv":["2108.02188"],"isi":["000758218600033"]},"acknowledgement":"This research was partially supported by the ERC CoG 863818 (ForM-SMArt), the Czech Science Foundation grant No. GJ19-15134Y, and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385.","isi":1,"article_processing_charge":"No","_id":"10414","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://arxiv.org/abs/2108.02188","open_access":"1"}],"date_created":"2021-12-05T23:01:45Z","day":"10","intvolume":"     13047","publication_status":"published"},{"author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Browning, Timothy D","last_name":"Browning","first_name":"Timothy D","orcid":"0000-0002-8314-0177"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"None","abstract":[{"lang":"eng","text":"The Hardy–Littlewood circle method was invented over a century ago to study integer solutions to special Diophantine equations, but it has since proven to be one of the most successful all-purpose tools available to number theorists. Not only is it capable of handling remarkably general systems of polynomial equations defined over arbitrary global fields, but it can also shed light on the space of rational curves that lie on algebraic varieties.  This book, in which the arithmetic of cubic polynomials takes centre stage, is aimed at bringing beginning graduate students into contact with some of the many facets of the circle method, both classical and modern. This monograph is the winner of the 2021 Ferran Sunyer i Balaguer Prize, a prestigious award for books of expository nature presenting the latest developments in an active area of research in mathematics."}],"citation":{"short":"T.D. Browning, Cubic Forms and the Circle Method, Springer Nature, Cham, 2021.","mla":"Browning, Timothy D. <i>Cubic Forms and the Circle Method</i>. Vol. 343, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/978-3-030-86872-7\">10.1007/978-3-030-86872-7</a>.","ieee":"T. D. Browning, <i>Cubic Forms and the Circle Method</i>, vol. 343. Cham: Springer Nature, 2021.","ista":"Browning TD. 2021. Cubic Forms and the Circle Method, Cham: Springer Nature, XIV, 166p.","chicago":"Browning, Timothy D. <i>Cubic Forms and the Circle Method</i>. Vol. 343. Cham: Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-86872-7\">https://doi.org/10.1007/978-3-030-86872-7</a>.","ama":"Browning TD. <i>Cubic Forms and the Circle Method</i>. Vol 343. Cham: Springer Nature; 2021. doi:<a href=\"https://doi.org/10.1007/978-3-030-86872-7\">10.1007/978-3-030-86872-7</a>","apa":"Browning, T. D. (2021). <i>Cubic Forms and the Circle Method</i> (Vol. 343). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-86872-7\">https://doi.org/10.1007/978-3-030-86872-7</a>"},"place":"Cham","date_created":"2021-12-05T23:01:46Z","day":"01","publication_identifier":{"eisbn":["978-3-030-86872-7"],"isbn":["978-3-030-86871-0"],"eissn":["2296-505X"],"issn":["0743-1643"]},"type":"book","date_updated":"2024-10-09T21:01:16Z","publication_status":"published","year":"2021","intvolume":"       343","title":"Cubic Forms and the Circle Method","publisher":"Springer Nature","department":[{"_id":"TiBr"}],"page":"XIV, 166","corr_author":"1","date_published":"2021-12-01T00:00:00Z","volume":343,"language":[{"iso":"eng"}],"alternative_title":["Progress in Mathematics"],"status":"public","quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","_id":"10415","month":"12","doi":"10.1007/978-3-030-86872-7"}]