[{"author":[{"full_name":"Diao, Yijie","last_name":"Diao","id":"7b7eb4ca-eb2c-11ec-b98b-accec0b20c3b","first_name":"Yijie","orcid":"0000-0002-4989-5330"}],"mathsc":["11N32","11N37","11D57","11G35"],"publication":"Glasgow Mathematical Journal","scopus_import":"1","corr_author":"1","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1017/S0017089526101074","open_access":"1"}],"doi":"10.1017/s0017089526101074","title":"Liouville function, von Mangoldt function, and norm forms at random binary forms","oa":1,"publication_identifier":{"issn":["0017-0895"],"eissn":["1469-509X"]},"license":"https://creativecommons.org/licenses/by/4.0/","month":"07","publication_status":"epub_ahead","language":[{"iso":"eng"}],"department":[{"_id":"TiBr"},{"_id":"GradSch"}],"page":"1-34","quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","date_created":"2026-08-04T06:15:04Z","supplementarymaterial":"no","abstract":[{"lang":"eng","text":"We analyze the average behavior of various arithmetic functions at the values of degree 𝑑 binary forms ordered by height, with probability 1. This approach yields averaged versions of the Chowla conjecture and the Bateman–Horn conjecture for random binary forms. Furthermore, we show that the rational Hasse principle holds for almost all ChĂątelet varieties defined by a fixed norm form of degree 𝑒 and by varying binary forms of fixed degree 𝑑, provided 𝑒 divides 𝑑. This proves an average version of a conjecture of Colliot-ThĂ©lĂšne."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-08-04T06:28:01Z","OA_place":"publisher","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1017/s0017089526101074","article_type":"original","has_accepted_license":"1","date_published":"2026-07-21T00:00:00Z","OA_type":"hybrid","PlanS_conform":"1","ddc":["500"],"publisher":"Cambridge University Press","year":"2026","citation":{"chicago":"Diao, Yijie. “Liouville Function, von Mangoldt Function, and Norm Forms at Random Binary Forms.” Glasgow Mathematical Journal. Cambridge University Press, 2026. https://doi.org/10.1017/s0017089526101074.","short":"Y. Diao, Glasgow Mathematical Journal (2026) 1–34.","mla":"Diao, Yijie. “Liouville Function, von Mangoldt Function, and Norm Forms at Random Binary Forms.” Glasgow Mathematical Journal, Cambridge University Press, 2026, pp. 1–34, doi:10.1017/s0017089526101074.","ista":"Diao Y. 2026. Liouville function, von Mangoldt function, and norm forms at random binary forms. Glasgow Mathematical Journal., 1–34.","ama":"Diao Y. Liouville function, von Mangoldt function, and norm forms at random binary forms. Glasgow Mathematical Journal. 2026:1-34. doi:10.1017/s0017089526101074","ieee":"Y. Diao, “Liouville function, von Mangoldt function, and norm forms at random binary forms,” Glasgow Mathematical Journal. Cambridge University Press, pp. 1–34, 2026.","apa":"Diao, Y. (2026). Liouville function, von Mangoldt function, and norm forms at random binary forms. Glasgow Mathematical Journal. Cambridge University Press. https://doi.org/10.1017/s0017089526101074"},"acknowledgement":"I am deeply grateful to my advisor Tim Browning for suggesting this problem and for the many valuable discussions that shaped this work. I would also like to thank Efthymios Sofos, Matteo Verzobio, and Shuntaro Yamagishi for discussions and insights that contributed to this paper. I am also very grateful to the anonymous referee for their careful reading and for the considerable effort they put into improving the manuscript.","das_tickbox":"0","arxiv":1,"day":"21","oa_version":"Published Version","_id":"22644","researchdata_availability":"no","status":"public","external_id":{"arxiv":["2506.18065"]}},{"article_type":"original","fulldoi":"https://doi.org/10.1145/3811353","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["Procedural animation"],"ddc":["006"],"OA_type":"gold","date_published":"2026-07-01T00:00:00Z","has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-08-04T09:07:44Z","file_date_updated":"2026-05-29T13:19:37Z","abstract":[{"text":"The appearance of simulated natural phenomena heavily depends on the way surfaces are textured. However, applying texture maps to dynamic deformable surfaces presents a significant challenge, due to ever-shifting differences in length scales involved. When these surfaces move and advect the texture along with them, their final appearance degrades as deformed regions dramatically distort their texture map. Modifications to the texture directly at the pixel level in response to the deformation may introduce ghosting artifacts and look unnatural. In the real world, the appearance of surface details on a deforming material changes through the interplay of physical processes such as rupturing, exposure of internal structure, or wrinkling. Motivated by these behaviors, in this work we explore how physical principles can guide the texturing methods based on the measure of surface deformation.\r\nWe present two novel wave-based procedural texturing algorithms which reproduce common physical properties like advection and self-similarity, enabling the plausible animation of deforming objects with extreme texture map distortions. Our algorithms are fully procedural, require no actual physics simulation, and store no state or history of deformation besides the input UV map, making them highly parallelizable on the GPU and efficient enough for real-time applications. We show the versatility of the method by animating physical phenomena with extreme deformations such as flowing lava, stretching putty and outpouring sludge.","lang":"eng"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","acknowledged_ssus":[{"_id":"ScienComp"}],"file":[{"date_created":"2026-05-29T13:19:33Z","file_size":77337231,"file_name":"tog454-article154-supplemental.mp4","file_id":"21924","success":1,"creator":"akalinov","date_updated":"2026-05-29T13:19:33Z","content_type":"video/mp4","relation":"main_file","access_level":"open_access","checksum":"ea165bf731ddd3045f83878dcb833672"},{"access_level":"open_access","checksum":"6274cfb15ea5ba7324b74afc7b0d9629","relation":"main_file","creator":"akalinov","content_type":"video/mp4","date_updated":"2026-05-29T13:19:37Z","success":1,"file_id":"21925","file_size":226633977,"date_created":"2026-05-29T13:19:37Z","file_name":"tog454-article154-video.mp4"},{"relation":"main_file","checksum":"9d41b322a7876be9a3311017b9973183","access_level":"open_access","creator":"akalinov","content_type":"application/pdf","date_updated":"2026-05-29T13:19:33Z","file_id":"21926","success":1,"file_size":6793867,"date_created":"2026-05-29T13:19:33Z","file_name":"tog454-article154-supplemental.pdf"},{"date_updated":"2026-05-29T13:19:36Z","content_type":"application/pdf","creator":"akalinov","relation":"main_file","checksum":"51bc60d2de867fbfa570652dec7993b4","access_level":"open_access","file_name":"tog454-article154-main-1.pdf","date_created":"2026-05-29T13:19:36Z","file_size":84173392,"file_id":"21927","success":1}],"intvolume":" 45","issue":"4","oa_version":"Published Version","_id":"21923","status":"public","researchdata_availability":"no","acknowledgement":"We thank the anonymous reviewers for their helpful comments, the members of the Visual Computing Group at ISTA for their feedback. We also thank Jonathan Gagnon for their help with running the Lapped Textures codes and SideFX for the Houdini Education software licenses.\r\nImages in Fig. 2 by Kisoulou and Vultured on Unsplash, Michal Jarmoluk and Public Domain Pictures from Pixabay and Hawai‘i Volcanoes NPS on flickr. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by Scientific Computing and was funded in part by the European Union (ERC-2021-COG 101045083 CoDiNA).","citation":{"chicago":"Kalinov, Aleksei, MickaĂ«l Ly, Christian Hafner, and Chris Wojtan. “Physics-Inspired Procedural Texturing of Extremely Deformable Surfaces.” ACM Transactions on Graphics. Association for Computing Machinery, 2026. https://doi.org/10.1145/3811353.","mla":"Kalinov, Aleksei, et al. “Physics-Inspired Procedural Texturing of Extremely Deformable Surfaces.” ACM Transactions on Graphics, vol. 45, no. 4, 154, Association for Computing Machinery, 2026, doi:10.1145/3811353.","short":"A. Kalinov, M. Ly, C. Hafner, C. Wojtan, ACM Transactions on Graphics 45 (2026).","ista":"Kalinov A, Ly M, Hafner C, Wojtan C. 2026. Physics-inspired procedural texturing of extremely deformable surfaces. ACM Transactions on Graphics. 45(4), 154.","ama":"Kalinov A, Ly M, Hafner C, Wojtan C. Physics-inspired procedural texturing of extremely deformable surfaces. ACM Transactions on Graphics. 2026;45(4). doi:10.1145/3811353","ieee":"A. Kalinov, M. Ly, C. Hafner, and C. Wojtan, “Physics-inspired procedural texturing of extremely deformable surfaces,” ACM Transactions on Graphics, vol. 45, no. 4. Association for Computing Machinery, 2026.","apa":"Kalinov, A., Ly, M., Hafner, C., & Wojtan, C. (2026). Physics-inspired procedural texturing of extremely deformable surfaces. ACM Transactions on Graphics. Los Angeles, CA, United States: Association for Computing Machinery. https://doi.org/10.1145/3811353"},"year":"2026","publisher":"Association for Computing Machinery","das_tickbox":"0","day":"01","doi":"10.1145/3811353","type":"journal_article","publication_identifier":{"issn":["0730-0301"]},"title":"Physics-inspired procedural texturing of extremely deformable surfaces","oa":1,"article_number":"154","scopus_import":"1","corr_author":"1","conference":{"start_date":"2026-07-19","location":"Los Angeles, CA, United States","name":"SIGGRAPH: International Conference and Exhibition on Computer Graphics and Interactive Techniques","end_date":"2026-07-23"},"author":[{"last_name":"Kalinov","id":"44b7120e-eb97-11eb-a6c2-e1557aa81d02","full_name":"Kalinov, Aleksei","orcid":"0000-0003-2189-3904","first_name":"Aleksei"},{"first_name":"MickaĂ«l","full_name":"Ly, MickaĂ«l","last_name":"Ly","id":"6340d7f0-b48d-11eb-b10d-b7487e71d9f1"},{"first_name":"Christian","last_name":"Hafner","id":"400429CC-F248-11E8-B48F-1D18A9856A87","full_name":"Hafner, Christian"},{"last_name":"Wojtan","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","full_name":"Wojtan, Christopher J","orcid":"0000-0001-6646-5546","first_name":"Christopher J"}],"publication":"ACM Transactions on Graphics","supplementarymaterial":"yes","date_created":"2026-05-29T13:25:16Z","article_processing_charge":"Yes","related_material":{"link":[{"url":"https://ista.ac.at/en/news/infinite-deformation-and-shape-computation/","description":"News on ISTA website","relation":"press_release"}]},"quality_controlled":"1","project":[{"grant_number":"101045083","name":"Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","_id":"34bc2376-11ca-11ed-8bc3-9a3b3961a088"}],"language":[{"iso":"eng"}],"volume":45,"department":[{"_id":"GradSch"},{"_id":"ChWo"}],"publication_status":"published","month":"07"},{"publication_status":"published","volume":123,"language":[{"iso":"eng"}],"department":[{"_id":"GaTk"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","month":"07","article_processing_charge":"Yes","date_created":"2026-07-19T22:01:46Z","supplementarymaterial":"yes","related_material":{"link":[{"url":"https://ista.ac.at/en/news/the-art-of-proper-flickering/","relation":"press_release","description":"News on ISTA website"}]},"quality_controlled":"1","project":[{"_id":"7bfe6a29-9f16-11ee-852c-c0da5e2045d9","name":"Transcription in 4D: the dynamic interplay between chromatin architecture and gene expression in developing pseudo-embryos","grant_number":"101118866"}],"scopus_import":"1","corr_author":"1","author":[{"full_name":"Zoller, Benjamin","last_name":"Zoller","first_name":"Benjamin"},{"first_name":"Alexis","full_name":"Benichou, Alexis","last_name":"Benichou","id":"3a67230c-5fc0-11ef-a673-de9a2ffadafe"},{"last_name":"Gregor","full_name":"Gregor, Thomas","first_name":"Thomas"},{"orcid":"0000-0002-6699-1455","first_name":"GaĆĄper","full_name":"Tkačik, GaĆĄper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkačik"}],"publication":"Proceedings of the National Academy of Sciences of the United States of America","type":"journal_article","doi":"10.1073/pnas.2524855123","oa":1,"title":"Invariant nonequilibrium dynamics in gene regulation optimize information flow","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"pmid":1,"article_number":"e2524855123","oa_version":"Published Version","_id":"22363","researchdata_availability":"yes","status":"public","publisher":"National Academy of Sciences","acknowledgement":"This work was supported by the French NationalResearch Agency (ANR-20-CE12-0028 “ChroDynE” and ANR-23-CE13-0021“GastruCyp” and ANR-10 LABX-73 “Revive;” all T.G.), and by funding from theEuropean Research Council (ERC-2023-SyG, “Dynatrans,” 101118866, T.G. andG.T.). This work was also supported in part by the U.S. NSF, through the Centerfor the Physics of Biological Function (PHY-1734030, T.G.), and by NIH GrantsR01GM097275, U01DA047730, and U01DK127429 (T.G.)","year":"2026","citation":{"chicago":"Zoller, Benjamin, Alexis Benichou, Thomas Gregor, and GaĆĄper Tkačik. “Invariant Nonequilibrium Dynamics in Gene Regulation Optimize Information Flow.” Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences, 2026. https://doi.org/10.1073/pnas.2524855123.","short":"B. Zoller, A. Benichou, T. Gregor, G. Tkačik, Proceedings of the National Academy of Sciences of the United States of America 123 (2026).","mla":"Zoller, Benjamin, et al. “Invariant Nonequilibrium Dynamics in Gene Regulation Optimize Information Flow.” Proceedings of the National Academy of Sciences of the United States of America, vol. 123, no. 28, e2524855123, National Academy of Sciences, 2026, doi:10.1073/pnas.2524855123.","ama":"Zoller B, Benichou A, Gregor T, Tkačik G. Invariant nonequilibrium dynamics in gene regulation optimize information flow. Proceedings of the National Academy of Sciences of the United States of America. 2026;123(28). doi:10.1073/pnas.2524855123","ista":"Zoller B, Benichou A, Gregor T, Tkačik G. 2026. Invariant nonequilibrium dynamics in gene regulation optimize information flow. Proceedings of the National Academy of Sciences of the United States of America. 123(28), e2524855123.","ieee":"B. Zoller, A. Benichou, T. Gregor, and G. Tkačik, “Invariant nonequilibrium dynamics in gene regulation optimize information flow,” Proceedings of the National Academy of Sciences of the United States of America, vol. 123, no. 28. National Academy of Sciences, 2026.","apa":"Zoller, B., Benichou, A., Gregor, T., & Tkačik, G. (2026). Invariant nonequilibrium dynamics in gene regulation optimize information flow. Proceedings of the National Academy of Sciences of the United States of America. National Academy of Sciences. https://doi.org/10.1073/pnas.2524855123"},"day":"14","das_tickbox":"1","dataavailabilitystatement":"Software code data have been deposited in Institute Pasteur GitHub (https://gitlab.pasteur.fr/tglab/invariantpromoterdynamicspaper) (51).","intvolume":" 123","file":[{"file_id":"22376","success":1,"file_name":"2026_PNAS_Zoller.pdf","file_size":24580098,"date_created":"2026-07-20T13:12:47Z","relation":"main_file","access_level":"open_access","checksum":"f4d82dd706ff1629db68d71190288350","date_updated":"2026-07-20T13:12:47Z","content_type":"application/pdf","creator":"dernst"}],"issue":"28","external_id":{"pmid":["42406962"]},"date_updated":"2026-08-04T09:21:10Z","abstract":[{"lang":"eng","text":"Eukaryotic gene regulation relies on stochastic yet controlled promoter switching, in which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies have revealed a surprising invariance of the “switching correlation time” (TC)—the characteristic decay time of the autocorrelation function of promoter activity fluctuations—across gene expression levels in multiple genes and organisms. A biophysically plausible explanation for this invariance has so far been lacking. Here, we show that this empirical constraint imposes stringent requirements on minimal yet realistic models of transcriptional regulation. Specifically, reproducing TC–invariance requires regulatory architectures with at least four internal states and nonequilibrium dynamics that break detailed balance. Using Bayesian inference on Drosophila gap gene expression data, we demonstrate that such models i) quantitatively reproduce the observed TC–invariance, ii) remain robust to parameter perturbations, and iii) maximize information transmission from transcription factor concentration to gene expression. Remarkably, the TC-invariant modulation strategy we identify as optimal closely parallels contemporary control-theoretic results on the modulation of stochastic switching systems. Taken together, our results suggest that eukaryotic transcriptional regulation operates in a nonequilibrium regime to balance precision, reaction-rate limitations, and energy dissipation, thereby achieving near-optimal information transmission under fundamental physical constraints."}],"file_date_updated":"2026-07-20T13:12:47Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"article_type":"original","fulldoi":"https://doi.org/10.1073/pnas.2524855123","has_accepted_license":"1","date_published":"2026-07-14T00:00:00Z","OA_type":"hybrid","ddc":["570"],"OA_place":"publisher"},{"OA_place":"publisher","ddc":["570"],"PlanS_conform":"1","date_published":"2026-06-17T00:00:00Z","has_accepted_license":"1","OA_type":"hybrid","fulldoi":"https://doi.org/10.1038/s41586-026-10679-1","article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","abstract":[{"lang":"eng","text":"Despite the functional diversity of over 100 causal genes1,2,3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences emerged in neurons at early postnatal stages. These changes included downregulation of synaptic and ion channel-related genes, consistent with homeostatic adaptation or delayed maturation. Network analysis showed molecular convergence across models within each developmental stage, suggesting that diverse mutations linked to ASD impinge on common, stage-specific processes. Convergence becomes less pronounced by postnatal day 14, highlighting the dynamic nature of ASD-associated changes. Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology corroborated this pattern: mutants generally showed altered neuronal excitability and synaptic properties with model-specific nuances. Our study also highlighted sex-specific gene expression alterations, with female mice often displaying larger effect sizes than male mice. Together, our findings provide a comprehensive view of developmental cellular and molecular dynamics across models of ASD."}],"date_updated":"2026-08-04T09:29:55Z","external_id":{"pmid":["42310454"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"dataavailabilitystatement":"Single-nucleus multiomics data are available from the Gene Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment (refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz). Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz). Source data are provided with this paper. Scripts and analyses that support the main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome).","day":"17","acknowledgement":"We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical assistance; A. Stichelberger and S. Liegenfeld for the management of our animal colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance; C. Jansen and the Scientific Computing Facility for bioinformatics support and technical assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted in Fig. 1; and all members of the laboratory of G.N. for their support and discussions. This study was supported by the Scientific Service Units of ISTA through resources provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter Core Facilities, member of the Vienna BioCenter. This work was supported by a European Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding provided by Institute of Science and Technology (IST Austria).","year":"2026","citation":{"chicago":"Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph BĂŒschl, Sabrina LadstĂ€tter, et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10679-1.","short":"L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. BĂŒschl, S. LadstĂ€tter, B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi, T. Belinova, S. Reichl, G. SendĆŸikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M. Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino, Nature (2026).","mla":"Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10679-1.","ama":"Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026. doi:10.1038/s41586-026-10679-1","ista":"Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, BĂŒschl C, LadstĂ€tter S, Oliveira B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl S, SendĆŸikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics across autism spectrum disorder mouse models. Nature.","apa":"Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., BĂŒschl, C., 
 Novarino, G. (2026). Cortical development dynamics across autism spectrum disorder mouse models. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10679-1","ieee":"L. A. Schwarz et al., “Cortical development dynamics across autism spectrum disorder mouse models,” Nature. Springer Nature, 2026."},"publisher":"Springer Nature","_id":"22295","status":"public","researchdata_availability":"yes","oa_version":"Published Version","pmid":1,"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"oa":1,"title":"Cortical development dynamics across autism spectrum disorder mouse models","main_file_link":[{"url":"https://doi.org/10.1038/s41586-026-10679-1","open_access":"1"}],"doi":"10.1038/s41586-026-10679-1","type":"journal_article","publication":"Nature","author":[{"full_name":"Schwarz, Lena A","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","last_name":"Schwarz","first_name":"Lena A"},{"first_name":"Christoph","orcid":"0000-0002-9033-9096","full_name":"Dotter, Christoph","last_name":"Dotter","id":"4C66542E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Isaev","full_name":"Isaev, Sergey","first_name":"Sergey"},{"first_name":"Michela","full_name":"Lisi, Michela","id":"39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c","last_name":"Lisi"},{"last_name":"Malzl","full_name":"Malzl, Daniel","first_name":"Daniel"},{"last_name":"BĂŒschl","id":"2a8c054c-0913-11ee-9159-f8ef515809ed","full_name":"BĂŒschl, Christoph","first_name":"Christoph"},{"last_name":"LadstĂ€tter","full_name":"LadstĂ€tter, Sabrina","first_name":"Sabrina"},{"first_name":"BĂĄrbara","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","last_name":"Oliveira","full_name":"Oliveira, BĂĄrbara"},{"first_name":"Matteo","last_name":"Barel","id":"8959927b-2236-11ed-bd6e-ea83d94ade0e","full_name":"Barel, Matteo"},{"id":"36035796-5ACA-11E9-A75E-7AF2E5697425","last_name":"Basilico","full_name":"Basilico, Bernadette","orcid":"0000-0003-1843-3173","first_name":"Bernadette"},{"id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E","last_name":"Chintaluri","full_name":"Chintaluri, Chaitanya","orcid":"0000-0003-4252-1608","first_name":"Chaitanya"},{"first_name":"Sarah","full_name":"Gorkiewicz, Sarah","last_name":"Gorkiewicz","id":"f141a35d-15a9-11ec-9fb2-fef6becc7b6f"},{"first_name":"Mohammad","id":"3384113A-F248-11E8-B48F-1D18A9856A87","last_name":"Goudarzi","full_name":"Goudarzi, Mohammad"},{"first_name":"Tereza","id":"0bf89b6a-d28b-11eb-8bd6-f43768e4d368","last_name":"Belinova","full_name":"Belinova, Tereza"},{"first_name":"Stephan","last_name":"Reichl","full_name":"Reichl, Stephan"},{"first_name":"Gintarė","full_name":"SendĆŸikaitė, Gintarė","last_name":"SendĆŸikaitė","id":"dd6d52f2-c50d-11eb-9548-bcf0ff82b344"},{"full_name":"Arcot Jayaram, Satish","last_name":"Arcot Jayaram","id":"b0bbee33-09f7-11eb-909c-8b358058d28a","first_name":"Satish","orcid":"0000-0002-2479-2669"},{"id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","last_name":"Koppensteiner","full_name":"Koppensteiner, Peter","first_name":"Peter","orcid":"0000-0002-3509-1948"},{"last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","full_name":"Sommer, Christoph M","first_name":"Christoph M","orcid":"0000-0003-1216-9105"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181","first_name":"Tim P"},{"first_name":"Jörg","full_name":"Menche, Jörg","last_name":"Menche"},{"last_name":"Adameyko","full_name":"Adameyko, Igor","first_name":"Igor"},{"last_name":"Kharchenko","id":"0095641e-7eb7-11f1-8665-aec51a2ab5e0","full_name":"Kharchenko, Peter Vasili","first_name":"Peter Vasili"},{"full_name":"Bock, Christoph","last_name":"Bock","first_name":"Christoph"},{"full_name":"Novarino, Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","orcid":"0000-0002-7673-7178"}],"corr_author":"1","scopus_import":"1","project":[{"grant_number":"101044865","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6","name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders"},{"grant_number":"707964","name":"Critical windows and reversibility of ASD associated with mutations in chromatin remodelers","_id":"9B91375C-BA93-11EA-9121-9846C619BF3A"},{"call_identifier":"FWF","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232"},{"grant_number":"FG1803 49015","_id":"ebb38b5d-77a9-11ec-83b8-a42e08120a88","name":"Neurobiology of anxiety in autism spectrum disorders"}],"related_material":{"link":[{"url":"https://ista.ac.at/en/news/patterns-in-genetic-chaos/","description":"News on ISTA website","relation":"press_release"}]},"quality_controlled":"1","supplementarymaterial":"yes","date_created":"2026-07-13T09:47:21Z","article_processing_charge":"Yes (via OA deal)","month":"06","department":[{"_id":"AnKi"},{"_id":"GaNo"},{"_id":"TiVo"},{"_id":"ScienComp"},{"_id":"GradSch"},{"_id":"Bio"},{"_id":"PreCl"}],"language":[{"iso":"eng"}],"publication_status":"epub_ahead"},{"type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1038/s41587-026-03166-5","open_access":"1"}],"doi":"10.1038/s41587-026-03166-5","oa":1,"title":"Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles","pmid":1,"publication_identifier":{"issn":["1087-0156"],"eissn":["1546-1696"]},"author":[{"first_name":"Sai A","last_name":"Maddipatla","id":"e957f5e5-91c9-11f0-a95f-e090f66ecb4d","full_name":"Maddipatla, Sai A"},{"first_name":"Nadav E","last_name":"Sellam","id":"ef280fe0-91c9-11f0-a95f-8dea3f5bc513","full_name":"Sellam, Nadav E"},{"first_name":"Meital I","last_name":"Bojan","id":"11d88cf5-91ca-11f0-a95f-edf9f08f47b7","full_name":"Bojan, Meital I"},{"full_name":"Masalitin, Vova","id":"ff7958eb-91c9-11f0-a95f-f3bf65828cf6","last_name":"Masalitin","first_name":"Vova"},{"full_name":"Vedula, Sanketh","last_name":"Vedula","first_name":"Sanketh"},{"last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","first_name":"Paul"},{"last_name":"Marx","full_name":"Marx, Ailie","first_name":"Ailie"},{"last_name":"Bronstein","id":"58f3726e-7cba-11ef-ad8b-e6e8cb3904e6","full_name":"Bronstein, Alexander","first_name":"Alexander","orcid":"0000-0001-9699-8730"}],"publication":"Nature Biotechnology","scopus_import":"1","corr_author":"1","related_material":{"link":[{"description":"News on ISTA website","relation":"press_release","url":"https://ista.ac.at/en/news/toward-experiment-guided-alphafold/"}]},"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","date_created":"2026-07-12T22:02:19Z","supplementarymaterial":"yes","month":"06","publication_status":"epub_ahead","department":[{"_id":"PaSc"},{"_id":"AlBr"},{"_id":"GradSch"}],"language":[{"iso":"eng"}],"OA_place":"publisher","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1038/s41587-026-03166-5","article_type":"original","PlanS_conform":"1","has_accepted_license":"1","date_published":"2026-06-29T00:00:00Z","OA_type":"hybrid","ddc":["570"],"abstract":[{"text":"AlphaFold3 predicts highly accurate protein structures from sequence but tends to collapse to a single dominant conformation, even when the underlying structure is inherently heterogeneous. Moreover, its predictions are oblivious to experimental conditions that can alter local sequence conformation. In this work, we show that AlphaFold3 can be guided to match data obtained by nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography and cryogenic electron microscopy (cryo-EM) experiments and combinations thereof. Our approach can also incorporate data that explicitly report on dynamics, such as site-resolved order parameters. We demonstrate that this methodology generates compact structural ensembles whose ensemble-averaged observables agree with experiment, with fewer distance restraint violations than traditionally resolved NMR structures and with unmodeled alternate conformations uncovered in electron density. This methodology paves the way for experimentally aware predictive models that generate structural ensembles consistent with the measurements, potentially over multiple modalities, and that can be further refined toward thermodynamically grounded ensembles by incorporating energetics.","lang":"eng"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-08-04T09:25:18Z","external_id":{"pmid":["42374114"]},"dataavailabilitystatement":"All structures and metrics reported in this paper are openly available on Harvard Dataverse - https://doi.org/10.7910/DVN/PLYUHN. All code is openly available on GitHub (https://github.com/sai-advaith/guided_alphafold); the version used for this paper (version 0.9.1) is permanently archived on Zenodo https://doi.org/10.5281/zenodo.17307005","publisher":"Springer Nature","year":"2026","acknowledgement":"A. Marx acknowledges the financial support of the Helmsley Fellowships Program for Sustainability and Health. A.M.B. and P.S. are supported by the Institute of Science and Technology Austria Internal Project Call grant Generative Protein NMR. S.V. was supported in part by funding from the Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard. Open access funding provided by Institute of Science and Technology (IST Austria).","citation":{"mla":"Maddipatla, Sai A., et al. “Experiment-Guided AlphaFold3 Resolves Measurement-Consistent Protein Ensembles.” Nature Biotechnology, Springer Nature, 2026, doi:10.1038/s41587-026-03166-5.","short":"S.A. Maddipatla, N.E. Sellam, M.I. Bojan, V. Masalitin, S. Vedula, P. Schanda, A. Marx, A.M. Bronstein, Nature Biotechnology (2026).","chicago":"Maddipatla, Sai A, Nadav E Sellam, Meital I Bojan, Vova Masalitin, Sanketh Vedula, Paul Schanda, Ailie Marx, and Alex M. Bronstein. “Experiment-Guided AlphaFold3 Resolves Measurement-Consistent Protein Ensembles.” Nature Biotechnology. Springer Nature, 2026. https://doi.org/10.1038/s41587-026-03166-5.","apa":"Maddipatla, S. A., Sellam, N. E., Bojan, M. I., Masalitin, V., Vedula, S., Schanda, P., 
 Bronstein, A. M. (2026). Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-026-03166-5","ieee":"S. A. Maddipatla et al., “Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles,” Nature Biotechnology. Springer Nature, 2026.","ista":"Maddipatla SA, Sellam NE, Bojan MI, Masalitin V, Vedula S, Schanda P, Marx A, Bronstein AM. 2026. Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology.","ama":"Maddipatla SA, Sellam NE, Bojan MI, et al. Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles. Nature Biotechnology. 2026. doi:10.1038/s41587-026-03166-5"},"das_tickbox":"1","day":"29","oa_version":"Published Version","status":"public","_id":"22268","researchdata_availability":"yes"},{"OA_place":"publisher","has_accepted_license":"1","date_published":"2026-07-13T00:00:00Z","ddc":["572"],"tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"fulldoi":"https://doi.org/10.15479/AT-ISTA-22334","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","file_date_updated":"2026-07-16T09:17:08Z","abstract":[{"text":"Characterizing protein dynamics at the atomic level is essential for our understanding of biological mechanisms. Whether it is to facilitate metabolite transport, catalyze reactions, transmit signals, or regulate metabolism – proteins are constantly in motion and sample multiple conformational states to fulfill their function. Nuclear magnetic resonance (NMR) spectroscopy is particularly well suited to elucidate the dynamics of biomolecules on their complex free-energy landscape. In particular, solid-state magic-angle spinning (MAS) NMR enables the study of large molecular assemblies, protein crystals, or insoluble proteins at atomic resolution without an inherent molecular size limitation. MAS NMR experiments to probe protein dynamics are extremely versatile and sensitive to motional timescales from picoseconds to seconds. Over the past decades, technological advances, developments in experimental design, and new isotope-labeling approaches have further expanded the possibilities of this technique and significantly improved the accuracy of the determined motional parameters.\r\nFunctionally important sites of proteins often contain aromatic residues. Their side-chain motions have therefore long served as valuable indicators of mechanistically relevant dynamics in NMR studies. In this thesis, site-specifically labeled aromatic residues act as sensitive reporters for MAS NMR studies of protein dynamics. The first part addresses how different environments impact side-chain motion by probing ring flips of phenylalanines and tyrosines in crystalline proteins and amyloid fibrils. It provides important insights for the analysis of dynamics obtained in non-native protein environments and emphasizes the complex factors that determine the timescale of internal dynamics. In the second part, the focus shifts towards methodological questions regarding the investigation of protein dynamics by 19F MAS NMR. The fluorine nucleus exhibits promising characteristics for NMR studies but also presents significant challenges, which is why the full methodological potential of 19F MAS NMR has not been fully realized yet. This work demonstrates that paramagnetic doping can considerably reduce the measurement time and improve the sensitivity of fluorinated samples. Finally, 19F MAS NMR is evaluated as a tool for studying protein side-chain dynamics on the example of tryptophans. The results illustrate the challenges in analyzing such experiments and lay the foundation for further development of 19F MAS NMR relaxation studies.\r\nTaken together, this thesis highlights the potential of combining specific isotope labeling, MAS NMR, and complementary methods such as crystallography and computational simulations to elucidate internal protein dynamics. The further development of such integrative approaches will be crucial to improving our understanding of complex mechanisms and protein function.\r\n","lang":"eng"}],"date_updated":"2026-08-04T09:32:45Z","alternative_title":["ISTA Thesis"],"file":[{"file_id":"22346","file_size":99472908,"date_created":"2026-07-16T09:17:08Z","file_name":"2026_Becker_Lea_source_files.zip","relation":"source_file","access_level":"closed","checksum":"8b85114eff543916c0e1445cd2189555","creator":"lbecker","content_type":"application/zip","date_updated":"2026-07-16T09:17:08Z"},{"success":1,"file_id":"22347","file_name":"2026_Becker_Lea_Thesis.pdf","date_created":"2026-07-16T09:17:05Z","file_size":74647289,"checksum":"6c526862bc6dbd1e4c80ecb34580bc58","access_level":"open_access","relation":"main_file","date_updated":"2026-07-16T09:17:05Z","content_type":"application/pdf","creator":"lbecker"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"NMR"}],"supervisor":[{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","first_name":"Paul"}],"day":"13","das_tickbox":"1","publisher":"Institute of Science and Technology Austria","acknowledgement":"During the work on this thesis, I was the recipient of a DOC Fellowship of the Austrian\r\nAcademy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01).","year":"2026","citation":{"mla":"Becker, Lea Marie. Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-22334.","short":"L.M. Becker, Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR, Institute of Science and Technology Austria, 2026.","chicago":"Becker, Lea Marie. “Exploring Protein Dynamics Using Specific Labeling Approaches for Solid-State MAS NMR.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-22334.","apa":"Becker, L. M. (2026). Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-22334","ieee":"L. M. Becker, “Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR,” Institute of Science and Technology Austria, 2026.","ama":"Becker LM. Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. 2026. doi:10.15479/AT-ISTA-22334","ista":"Becker LM. 2026. Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR. Institute of Science and Technology Austria."},"status":"public","_id":"22334","oa_version":"Published Version","doi_confirm":"1","oa":1,"title":"Exploring protein dynamics using specific labeling approaches for solid-state MAS NMR","publication_identifier":{"isbn":["978-3-99078-084-8"],"issn":["2663-337X"]},"type":"dissertation","doi":"10.15479/AT-ISTA-22334","author":[{"full_name":"Becker, Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker","orcid":"0000-0002-6401-5151","first_name":"Lea Marie"}],"corr_author":"1","project":[{"grant_number":"26777","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches"}],"degree_awarded":"PhD","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"12675"},{"id":"21777","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"12114","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"22105"}]},"article_processing_charge":"No","date_created":"2026-07-14T08:08:51Z","month":"07","page":"205","publication_status":"published","language":[{"iso":"eng"}],"department":[{"_id":"GradSch"},{"_id":"PaSc"}]},{"corr_author":"1","scopus_import":"1","publication":"Nature Chemistry","author":[{"first_name":"Lea Marie","orcid":"0000-0002-6401-5151","full_name":"Becker, Lea Marie","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker"},{"last_name":"Fu","full_name":"Fu, Haohao","first_name":"Haohao"},{"first_name":"Benjamin","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","last_name":"Tatman","full_name":"Tatman, Benjamin"},{"full_name":"Dreydoppel, Matthias","last_name":"Dreydoppel","first_name":"Matthias"},{"id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova","full_name":"Kapitonova, Anna","first_name":"Anna"},{"orcid":"0000-0001-7597-043X","first_name":"Daniel","full_name":"Balazs, Daniel","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs"},{"full_name":"Weininger, Ulrich","last_name":"Weininger","first_name":"Ulrich"},{"first_name":"Sylvain","last_name":"Engilberge","full_name":"Engilberge, Sylvain"},{"first_name":"Christophe","last_name":"Chipot","full_name":"Chipot, Christophe"},{"orcid":"0000-0002-9350-7606","first_name":"Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda","full_name":"Schanda, Paul"}],"pmid":1,"publication_identifier":{"eissn":["17554349"],"issn":["17554330"]},"oa":1,"title":"Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes","doi":"10.1038/s41557-026-02155-0","type":"journal_article","page":"1221-1230","volume":18,"department":[{"_id":"PaSc"},{"_id":"LifeSc"}],"language":[{"iso":"eng"}],"publication_status":"published","month":"07","date_created":"2026-06-21T22:03:01Z","supplementarymaterial":"yes","article_processing_charge":"Yes (via OA deal)","project":[{"grant_number":"26777","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0"}],"quality_controlled":"1","related_material":{"record":[{"status":"public","id":"20641","relation":"research_data"},{"status":"public","id":"21145","relation":"research_data"},{"relation":"dissertation_contains","id":"22334","status":"public"}],"link":[{"url":"https://ista.ac.at/en/news/how-proteins-breathe/","description":"News on ISTA website","relation":"research_data"}]},"date_updated":"2026-08-04T09:32:45Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","abstract":[{"text":"Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein–protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labelling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a crystal structure of a GB1 variant reported in this work, reproduce these elevated barriers and reveal how the crystal restrains motions.","lang":"eng"}],"file_date_updated":"2026-07-28T06:58:35Z","ddc":["540"],"date_published":"2026-07-01T00:00:00Z","OA_type":"hybrid","has_accepted_license":"1","PlanS_conform":"1","fulldoi":"https://doi.org/10.1038/s41557-026-02155-0","article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"OA_place":"publisher","_id":"22105","researchdata_availability":"yes","status":"public","oa_version":"Published Version","day":"01","das_tickbox":"1","acknowledgement":"We thank N. R. Skrynnikov and O. O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to T. Schubeis (Lyon) for advice on GB1 crystallization and R. Schmid for initial crystallization trials. We thank C. Mueller-Dieckmann for assistance with room-temperature X-ray crystallography data collection on beamline ID30B at the ESRF, which is acknowledged for providing beamtime through its In-House Research programme. We thank S. Falkner for assistance with constructing the structural model of the IgG:GB1 complex. We thank J. Lewandowski for providing feedback on the paper and granting access to backbone relaxation data of IgG:GB1T2Q and GB1T2Q microcrystals. This research was supported by the Scientific Service Units (SSU) of the Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank P. RovĂł and M. V. FalcĂłn for excellent support of the NMR facility. L.M.B. is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant number PR10660EAW01). C.C. acknowledges the European Research Council (grant project 101097272 ‘MilliInMicro’) and the MĂ©tropole du Grand Nancy (grant project ‘ARC’). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.Open access funding provided by Institute of Science and Technology (IST Austria).","year":"2026","citation":{"chicago":"Becker, Lea Marie, Haohao Fu, Benjamin Tatman, Matthias Dreydoppel, Anna Kapitonova, Daniel Balazs, Ulrich Weininger, Sylvain Engilberge, Christophe Chipot, and Paul Schanda. “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Nature Chemistry. Springer Nature, 2026. https://doi.org/10.1038/s41557-026-02155-0.","mla":"Becker, Lea Marie, et al. “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Nature Chemistry, vol. 18, Springer Nature, 2026, pp. 1221–30, doi:10.1038/s41557-026-02155-0.","short":"L.M. Becker, H. Fu, B. Tatman, M. Dreydoppel, A. Kapitonova, D. Balazs, U. Weininger, S. Engilberge, C. Chipot, P. Schanda, Nature Chemistry 18 (2026) 1221–1230.","ista":"Becker LM, Fu H, Tatman B, Dreydoppel M, Kapitonova A, Balazs D, Weininger U, Engilberge S, Chipot C, Schanda P. 2026. Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. 18, 1221–1230.","ama":"Becker LM, Fu H, Tatman B, et al. Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. 2026;18:1221-1230. doi:10.1038/s41557-026-02155-0","apa":"Becker, L. M., Fu, H., Tatman, B., Dreydoppel, M., Kapitonova, A., Balazs, D., 
 Schanda, P. (2026). Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes. Nature Chemistry. Springer Nature. https://doi.org/10.1038/s41557-026-02155-0","ieee":"L. M. Becker et al., “Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes,” Nature Chemistry, vol. 18. Springer Nature, pp. 1221–1230, 2026."},"publisher":"Springer Nature","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"dataavailabilitystatement":"The cryo and room-temperature crystal structures of GB1QDD are deposited at the PDB under the access codes 9I2I and 9T8Z, respectively. The solid-state NMR backbone assignment of GB1QDD is deposited at the BMRB under the access code 53330. NMR spectra, analysis scripts and raw data are publicly available at the ISTA research explorer (https://doi.org/10.15479/AT-ISTA-20641)120. Files to reproduce the enhanced-sampling MD simulations are publicly available at the ISTA research explorer (https://doi.org/10.15479/AT-ISTA-21145)121.","external_id":{"pmid":["42271006"]},"file":[{"relation":"main_file","checksum":"1069fb27949fd2cb641b043b3a96a580","access_level":"open_access","date_updated":"2026-07-28T06:58:35Z","content_type":"application/pdf","creator":"dernst","file_id":"22595","success":1,"file_name":"2026_NatureChemistry_Becker.pdf","date_created":"2026-07-28T06:58:35Z","file_size":2618184}],"intvolume":" 18"},{"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"fulldoi":"https://doi.org/10.15479/AT-ISTA-21145","date_published":"2026-02-09T00:00:00Z","has_accepted_license":"1","ddc":["572"],"date_updated":"2026-08-04T09:32:45Z","file_date_updated":"2026-02-05T13:52:41Z","abstract":[{"lang":"eng","text":"Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein-protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labeling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a new crystal structure, reproduce these elevated barriers and reveal how the crystal restrains motions. "}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"file":[{"file_id":"21146","date_created":"2026-02-05T13:52:37Z","file_size":4263,"file_name":"README.txt","relation":"table_of_contents","checksum":"02a419cce8cea450bc952f35488d2df5","access_level":"open_access","creator":"lbecker","date_updated":"2026-02-05T13:52:37Z","content_type":"text/plain"},{"date_updated":"2026-02-05T13:52:41Z","content_type":"application/zip","creator":"lbecker","relation":"main_file","access_level":"open_access","checksum":"b0b82b1aa73985b0b308a3fa52d21aea","file_name":"Research_Data.zip","file_size":50647107,"date_created":"2026-02-05T13:52:41Z","file_id":"21147","success":1}],"oa_version":"Published Version","_id":"21145","status":"public","publisher":"Institute of Science and Technology Austria","acknowledgement":"We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance with constructing the structural model of the IgG:GB1 complex.\r\nThis research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra RovĂł and Margarita Valhondo FalcĂłn for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research Council (grant project 101097272 ``MilliInMicro'') and the MĂ©tropole du Grand Nancy (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.","year":"2026","citation":{"ista":"Becker LM, Schanda P, Chipot C. 2026. Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-21145.","ama":"Becker LM, Schanda P, Chipot C. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” 2026. doi:10.15479/AT-ISTA-21145","ieee":"L. M. Becker, P. Schanda, and C. Chipot, “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026.","apa":"Becker, L. M., Schanda, P., & Chipot, C. (2026). Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21145","chicago":"Becker, Lea Marie, Paul Schanda, and Christophe Chipot. “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21145.","mla":"Becker, Lea Marie, et al. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21145.","short":"L.M. Becker, P. Schanda, C. Chipot, (2026)."},"day":"09","type":"research_data","doi":"10.15479/AT-ISTA-21145","title":"Additional Data for \"Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes\"","oa":1,"contributor":[{"contributor_type":"researcher","first_name":"Haohao","last_name":"Fu"},{"first_name":"Benjamin","contributor_type":"researcher","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","last_name":"Tatman"},{"last_name":"Dreydoppel","first_name":"Matthias","contributor_type":"researcher"},{"last_name":"Kapitonova","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","first_name":"Anna","contributor_type":"researcher"},{"first_name":"Daniel","orcid":"0000-0001-7597-043X","contributor_type":"researcher","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs"},{"last_name":"Weininger","contributor_type":"researcher","first_name":"Ulrich"},{"last_name":"Engilberge","first_name":"Sylvain","contributor_type":"researcher"}],"corr_author":"1","author":[{"orcid":"0000-0002-6401-5151","first_name":"Lea Marie","last_name":"Becker","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","full_name":"Becker, Lea Marie"},{"full_name":"Schanda, Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda","orcid":"0000-0002-9350-7606","first_name":"Paul"},{"first_name":"Christophe","full_name":"Chipot, Christophe","last_name":"Chipot"}],"article_processing_charge":"No","date_created":"2026-02-05T13:54:39Z","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"20641"},{"relation":"used_in_publication","id":"22105","status":"public"}]},"project":[{"grant_number":"26777","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches","_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0"}],"department":[{"_id":"GradSch"},{"_id":"PaSc"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","month":"02"},{"OA_place":"publisher","DOAJ_listed":"1","ddc":["530"],"PlanS_conform":"1","OA_type":"gold","date_published":"2026-06-05T00:00:00Z","has_accepted_license":"1","fulldoi":"https://doi.org/10.1038/s41467-026-74060-6","article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"A phase plate has long been sought in transmission electron microscopy (TEM) to maximize the image contrast of weakly-scattering objects like biomolecules. The laser phase plate (LPP) has recently demonstrated that an amplified, focused laser standing wave reliably phase shifts the electron beam, achieving phase-contrast TEM. Building on the single-beam LPP, here we introduce the crossed laser phase plate (XLPP): two laser standing waves which intersect in the diffraction plane. We present a theoretical model for the XLPP inside the microscope and show that, relative to the original LPP, it increases information transfer at low spatial frequencies while suppressing ghost images formed by Kapitza-Dirac diffraction. We also present a simple acquisition scheme, enabled by the XLPP, which further suppresses ghosts. Finally, we discuss practical considerations of XLPP design and show experimental results from a prototype. The results of this study chart the course for future developments of LPP hardware.","lang":"eng"}],"file_date_updated":"2026-08-03T06:48:08Z","date_updated":"2026-08-05T09:27:39Z","file":[{"relation":"main_file","checksum":"9bbcbaed3fd78e99cd728877332953c1","access_level":"open_access","date_updated":"2026-08-03T06:48:08Z","content_type":"application/pdf","creator":"dernst","file_id":"22624","success":1,"file_name":"2026_NatureComm_Petrov.pdf","file_size":2052058,"date_created":"2026-08-03T06:48:08Z"}],"intvolume":" 17","dataavailabilitystatement":"The simulated apoferritin exit wave and associated image simulation and analysis code used for generating the figures are available on Code Ocean (https://www.codeocean.com/).","day":"05","das_tickbox":"1","citation":{"mla":"Petrov, Petar N., et al. “Crossed Laser Phase Plates for Transmission Electron Microscopy.” Nature Communications, vol. 17, 7199, Springer Nature, 2026, doi:10.1038/s41467-026-74060-6.","short":"P.N. Petrov, J.T. Zhang, J.J. Axelrod, P.K. Olshin, H. MĂŒller, Nature Communications 17 (2026).","chicago":"Petrov, Petar N, Jessie T. Zhang, Jeremy J. Axelrod, Pavel K. Olshin, and Holger MĂŒller. “Crossed Laser Phase Plates for Transmission Electron Microscopy.” Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-74060-6.","ieee":"P. N. Petrov, J. T. Zhang, J. J. Axelrod, P. K. Olshin, and H. MĂŒller, “Crossed laser phase plates for transmission electron microscopy,” Nature Communications, vol. 17. Springer Nature, 2026.","apa":"Petrov, P. N., Zhang, J. T., Axelrod, J. J., Olshin, P. K., & MĂŒller, H. (2026). Crossed laser phase plates for transmission electron microscopy. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-026-74060-6","ama":"Petrov PN, Zhang JT, Axelrod JJ, Olshin PK, MĂŒller H. Crossed laser phase plates for transmission electron microscopy. Nature Communications. 2026;17. doi:10.1038/s41467-026-74060-6","ista":"Petrov PN, Zhang JT, Axelrod JJ, Olshin PK, MĂŒller H. 2026. Crossed laser phase plates for transmission electron microscopy. Nature Communications. 17, 7199."},"year":"2026","publisher":"Springer Nature","_id":"22613","status":"public","researchdata_availability":"no","oa_version":"Published Version","article_number":"7199","publication_identifier":{"eissn":["2041-1723"]},"title":"Crossed laser phase plates for transmission electron microscopy","oa":1,"doi":"10.1038/s41467-026-74060-6","type":"journal_article","publication":"Nature Communications","author":[{"last_name":"Petrov","id":"b1d6732d-8cb6-11f0-baab-bd460ee3a287","full_name":"Petrov, Petar N","first_name":"Petar N"},{"first_name":"Jessie T.","last_name":"Zhang","full_name":"Zhang, Jessie T."},{"first_name":"Jeremy J.","full_name":"Axelrod, Jeremy J.","last_name":"Axelrod"},{"last_name":"Olshin","full_name":"Olshin, Pavel K.","first_name":"Pavel K."},{"last_name":"MĂŒller","full_name":"MĂŒller, Holger","first_name":"Holger"}],"scopus_import":"1","quality_controlled":"1","date_created":"2026-08-02T22:01:51Z","supplementarymaterial":"yes","article_processing_charge":"Yes","month":"06","department":[{"_id":"MiLe"}],"language":[{"iso":"eng"}],"volume":17,"publication_status":"published"},{"intvolume":" 393","external_id":{"pmid":["42275466"]},"issue":"6807","dataavailabilitystatement":"The datasets are publicly available in the Electron Microscopy Public Image Archive [A1: EMPIAR-13528 (on), EMPIAR-13527 (off); A2: EMPIAR-13529 (on), EMPIAR-13526 (off); A3: EMPIAR-13530 (on), EMPIAR-13525 (off); H1: EMPIAR-13535 (on), EMPIAR-13533 (off); H2: EMPIAR-13534 (on), EMPIAR-13532 (off); H3: EMPIAR-13537 (on), EMPIAR-13531 (off)]. The final reconstructed maps are deposited in the Electron Microscopy Data Bank [A1: EMD-76790 (on), EMD-76791 (off); A2: EMD-76792 (on), EMD-76793 (off); A3: EMD-76794 (on), EMD-76797 (off); H1: EMD-76802 (on), EMD-76804 (off); H2: EMD-76805 (on), EMD-76806 (off); H3: EMD-76807 (on), EMD-76809 (off)]. The initial structures in Fig. 3 are deposited at EMD-76810 (on) and EMD-76811 (off). Code for converting EER movies to binned TIF format with proper accounting for electron dose is deposited in Zenodo (47) and available on GitHub at https://github.com/matterwaves/eer2tiff/releases/tag/v0.1.0. All specimen preparation materials are commercially available.","year":"2026","citation":{"mla":"Petrov, Petar N., et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” Science, vol. 393, no. 6807, AAAS, 2026, pp. 195–96, doi:10.1126/science.aeh0665.","short":"P.N. Petrov, J.T. Zhang, J. Remis, J.J. Axelrod, H. Cheng, E.S. Cooper, I.K. Hicklin, S. Sandhaus, C. Schnurr, R.M. Glaeser, H. MĂŒller, Science 393 (2026) 195–196.","chicago":"Petrov, Petar N, Jessie T. Zhang, Jonathan Remis, Jeremy J. Axelrod, Hang Cheng, Eric S. Cooper, Ian K. Hicklin, et al. “Laser Phase Plate Improves Structure Determination of Small Proteins by Cryo-EM.” Science. AAAS, 2026. https://doi.org/10.1126/science.aeh0665.","apa":"Petrov, P. N., Zhang, J. T., Remis, J., Axelrod, J. J., Cheng, H., Cooper, E. S., 
 MĂŒller, H. (2026). Laser phase plate improves structure determination of small proteins by cryo-EM. Science. AAAS. https://doi.org/10.1126/science.aeh0665","ieee":"P. N. Petrov et al., “Laser phase plate improves structure determination of small proteins by cryo-EM,” Science, vol. 393, no. 6807. AAAS, pp. 195–196, 2026.","ama":"Petrov PN, Zhang JT, Remis J, et al. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. 2026;393(6807):195-196. doi:10.1126/science.aeh0665","ista":"Petrov PN, Zhang JT, Remis J, Axelrod JJ, Cheng H, Cooper ES, Hicklin IK, Sandhaus S, Schnurr C, Glaeser RM, MĂŒller H. 2026. Laser phase plate improves structure determination of small proteins by cryo-EM. Science. 393(6807), 195–196."},"acknowledgement":"The authors thank O. Schwartz and S. Scheres for helpful remarks and discussions; D. Agard, B. Carragher, C. Potter, and P. Olshin for close collaboration; A. Singh, L. Maisenbacher, S. Strasser, and I. Pope for help with mirror inspection; J. Fang, E. Nogales, and J. Hurley for sharing their lab space and assisting with sample preparation; B. Buijsse, W. Hagen, B. Jiang, and T. Coyle at Thermo Fisher Scientific for the design of the custom transfer optics and technical support; G. Long and T. Gutierrez at the UC Berkeley Physics R&D Machine Shop for machining cavity components and tooling. This work was supported by the following: Chan Zuckerberg Initiative award numbers 2021-234606 and 2025-367757, National Institutes of Health grant R01GM126011, Gordon and Betty Moore Foundation grant 9366, Lawrence Berkeley National Laboratory Directed Research and Development Program grant 25-111, and Cooperative Research and Development Agreement award AWD00004352 (to H.M.); National Institutes of Health fellowship F32GM149186 (to P.N.P.).","publisher":"AAAS","day":"09","das_tickbox":"1","oa_version":"None","researchdata_availability":"yes","_id":"22365","status":"public","fulldoi":"https://doi.org/10.1126/science.aeh0665","article_type":"original","ddc":["570"],"has_accepted_license":"1","OA_type":"closed access","date_published":"2026-07-09T00:00:00Z","abstract":[{"text":"Phase plates can, in principle, overcome the poor image contrast in cryo–electron microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous designs have been unstable and compromised the high-resolution signal and have thus been unable to surpass results achieved by standard cryo-EM. Here, we show that the laser phase plate (LPP), installed in a modern, custom Titan Krios microscope, enhances the resolution in single-particle reconstruction of small proteins by improving specimen-motion correction and recovery of information from the early frames, as well as particle visualization, three-dimensional classification, and alignment. These advances use standard defocus ranges and reconstruction procedures but open the door to LPP-tailored protocols, offering further improvements by leveraging the LPP demonstrated here.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-08-05T09:27:38Z","quality_controlled":"1","date_created":"2026-07-19T22:01:46Z","supplementarymaterial":"yes","article_processing_charge":"No","month":"07","language":[{"iso":"eng"}],"department":[{"_id":"MiLe"}],"volume":393,"publication_status":"published","page":"195-196","doi":"10.1126/science.aeh0665","type":"journal_article","pmid":1,"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"title":"Laser phase plate improves structure determination of small proteins by cryo-EM","author":[{"first_name":"Petar N","full_name":"Petrov, Petar N","id":"b1d6732d-8cb6-11f0-baab-bd460ee3a287","last_name":"Petrov"},{"first_name":"Jessie T.","full_name":"Zhang, Jessie T.","last_name":"Zhang"},{"last_name":"Remis","full_name":"Remis, Jonathan","first_name":"Jonathan"},{"last_name":"Axelrod","full_name":"Axelrod, Jeremy J.","first_name":"Jeremy J."},{"last_name":"Cheng","full_name":"Cheng, Hang","first_name":"Hang"},{"first_name":"Eric S.","last_name":"Cooper","full_name":"Cooper, Eric S."},{"first_name":"Ian K.","last_name":"Hicklin","full_name":"Hicklin, Ian K."},{"full_name":"Sandhaus, Shahar","last_name":"Sandhaus","first_name":"Shahar"},{"last_name":"Schnurr","full_name":"Schnurr, Cooper","first_name":"Cooper"},{"full_name":"Glaeser, Robert M.","last_name":"Glaeser","first_name":"Robert M."},{"last_name":"MĂŒller","full_name":"MĂŒller, Holger","first_name":"Holger"}],"publication":"Science","scopus_import":"1"},{"article_processing_charge":"No","supplementarymaterial":"no","date_created":"2026-03-02T10:06:46Z","quality_controlled":"1","publication_status":"published","language":[{"iso":"eng"}],"volume":164,"department":[{"_id":"BiCh"}],"month":"02","title":"Long-range electrostatics for machine learning interatomic potentials is easier than we thought","oa":1,"publication_identifier":{"issn":["0021-9606"],"eissn":["1089-7690"]},"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2512.18029"}],"doi":"10.1063/5.0316886","article_number":"060901","corr_author":"1","scopus_import":"1","publication":"The Journal of Chemical Physics","author":[{"last_name":"Kim","full_name":"Kim, Dongjin","first_name":"Dongjin"},{"last_name":"Cheng","id":"cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9","full_name":"Cheng, Bingqing","first_name":"Bingqing","orcid":"0000-0002-3584-9632"}],"dataavailabilitystatement":"The RPBE-D3 bulk water dataset, training scripts, evaluation scripts, the trained CACE E + F + Qeq model, and CACE LES and MACE LES models used to produce results shown in Figs. 2(c)–2(e) are available at https://github.com/ChengUCB/les_fit.\r\n\r\nThe LES library is publicly available at https://github.com/ChengUCB/les. The CACE package with the LES implementation is available at https://github.com/BingqingCheng/cace. The MACE package with the LES implementation is available at https://github.com/ACEsuit/mace. The NequIP and Allegro LES extension package is available at https://github.com/ChengUCB/NequIP-LES. The MatGL package with the LES implementation is available at https://github.com/ChengUCB/matgl. The UMA package with the LES implementation is available at https://github.com/santi921/fairchem/tree/les_branch.","issue":"6","external_id":{"arxiv":["2512.18029"]},"intvolume":" 164","_id":"21381","status":"public","researchdata_availability":"yes","oa_version":"Preprint","day":"14","das_tickbox":"1","arxiv":1,"publisher":"AIP Publishing","citation":{"chicago":"Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics. AIP Publishing, 2026. https://doi.org/10.1063/5.0316886.","mla":"Kim, Dongjin, and Bingqing Cheng. “Long-Range Electrostatics for Machine Learning Interatomic Potentials Is Easier than We Thought.” The Journal of Chemical Physics, vol. 164, no. 6, 060901, AIP Publishing, 2026, doi:10.1063/5.0316886.","short":"D. Kim, B. Cheng, The Journal of Chemical Physics 164 (2026).","ista":"Kim D, Cheng B. 2026. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 164(6), 060901.","ama":"Kim D, Cheng B. Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. 2026;164(6). doi:10.1063/5.0316886","ieee":"D. Kim and B. Cheng, “Long-range electrostatics for machine learning interatomic potentials is easier than we thought,” The Journal of Chemical Physics, vol. 164, no. 6. AIP Publishing, 2026.","apa":"Kim, D., & Cheng, B. (2026). Long-range electrostatics for machine learning interatomic potentials is easier than we thought. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/5.0316886"},"year":"2026","acknowledgement":"B.C. thanks Christoph Dellago for his mentorship and influence. In addition to his seminal contributions to statistical mechanics, Christoph Dellago is an early developer and adopter of machine learning interatomic potentials. B.C. did two exchanges in the groups of Christoph Dellago and Jörg Behler in 2018, with transformative impact on her research directions.\r\n\r\nWe thank Peichen Zhong and Daniel S. King for useful feedback on the manuscript and for the collaborations on the LES method.\r\n\r\nFunding acknowledgment: Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award No. R35GM159986. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.","OA_type":"free access","date_published":"2026-02-14T00:00:00Z","article_type":"original","fulldoi":"https://doi.org/10.1063/5.0316886","OA_place":"repository","date_updated":"2026-08-07T09:33:14Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"text":"The lack of long-range electrostatics is a key limitation of modern machine learning interatomic potentials (MLIPs), hindering reliable applications to interfaces, charge-transfer reactions, polar and ionic materials, and biomolecules. In this Perspective, we distill two design principles behind the Latent Ewald Summation framework, which can capture long-range interactions, charges, and electrical response just by learning from standard energy and force training data: (i) use a Coulomb functional form with environment-dependent charges to capture electrostatic interactions, and (ii) avoid explicit training on ambiguous density functional theory partial charges. When both principles are satisfied, substantial flexibility remains: essentially any short-range MLIP can be augmented; charge equilibration schemes can be added when desired; dipoles and Born effective charges can be inferred or fine-tuned; and charge/spin-state embeddings or tensorial targets can be further incorporated. We also discuss current limitations and open challenges. Together, these minimal, physics-guided design rules suggest that incorporating long-range electrostatics into MLIPs is simpler and perhaps more broadly applicable than is commonly assumed.","lang":"eng"}]},{"publication":"Astronomy & Astrophysics","author":[{"first_name":"Lukas","full_name":"Einramhof, Lukas","last_name":"Einramhof","id":"f1497a1a-72ef-11ef-b75a-fd877bbf6e8c"},{"orcid":"0000-0003-0142-4000","first_name":"Lisa Annabelle","full_name":"Bugnet, Lisa Annabelle","last_name":"Bugnet","id":"d9edb345-f866-11ec-9b37-d119b5234501"},{"last_name":"Calcaferro","full_name":"Calcaferro, L. M.","first_name":"L. M."},{"full_name":"Barrault, Lucas","last_name":"Barrault","id":"4471a8fd-32c1-11ee-a9a4-fb670d398f64","first_name":"Lucas"},{"first_name":"S. B.","full_name":"Das, S. B.","last_name":"Das"}],"corr_author":"1","scopus_import":"1","article_number":"L14","title":"Magneto-archeology of white dwarfs","oa":1,"publication_identifier":{"eissn":["1432-0746"],"issn":["0004-6361"]},"type":"journal_article","doi":"10.1051/0004-6361/202659069","month":"04","publication_status":"published","department":[{"_id":"LiBu"},{"_id":"GradSch"}],"volume":708,"language":[{"iso":"eng"}],"project":[{"grant_number":"101165631","_id":"914d8549-16d5-11f0-9cad-bbe6324c93a9","name":"Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology"},{"grant_number":"27648","_id":"5b62812b-ab3d-11f0-914f-8f3a9cdb4af7","name":"Unveiling the structure and dynamics of the deep convective core - radiative zone boundary throughout stellar evolution"}],"quality_controlled":"1","article_processing_charge":"No","date_created":"2026-08-10T07:53:32Z","supplementarymaterial":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"The detection of strong, large-scale magnetic fields at the surfaces of the oldest white dwarfs might point toward a hidden internal magnetic field slowly rising to the surface. In addition, strong magnetic fields have recently been measured through asteroseismology in the radiative interiors of red giant stars, the progenitors of white dwarfs. To investigate the potential connection between these observations, we revisited the fossil field framework using asteroseismic detections to constrain the strength of such magnetic fields as red giants evolve into the white dwarf stage. We assumed that the magnetic field was either created during the core convection on the main sequence or that it fills the radiative interior as the star evolves on the red giant branch. From these initial conditions, we evolved the magnetic flux, allowing for magnetic diffusion along the evolution of a modeled 1.5 M⊙ star. We find that measured field strengths in red giants attributed to the hydrogen-burning shell are compatible with the field amplitudes and emergence timescales of magnetized white dwarfs. On the contrary, magnetic fields generated solely from a convective-core dynamo on the main sequence and detectable on the red giant branch would be buried too deep in the star and would not match the breakout timescales or the field strengths of magnetic white dwarfs. Therefore, for us to connect magnetic fields observed along the late evolution of stars via a fossil field we would need to find a broadly magnetized internal radiative zone on the red giant branch."}],"file_date_updated":"2026-08-11T05:46:02Z","date_updated":"2026-08-11T05:49:20Z","DOAJ_listed":"1","OA_place":"publisher","PlanS_conform":"1","has_accepted_license":"1","date_published":"2026-04-01T00:00:00Z","OA_type":"diamond","ddc":["520"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","fulldoi":"https://doi.org/10.1051/0004-6361/202659069","day":"01","das_tickbox":"1","arxiv":1,"publisher":"EDP Sciences","acknowledgement":"The authors thank the referee for their helpful and constructive report, which has significantly enhanced the quality of the manuscript.\r\nThe authors thank I. Caiazzo, L. Ferrario, and L. Buchele for very useful discussions. L. Barrault, L. Bugnet, and L. Einramhof gratefully acknowledge support from the European Research Council (ERC) under the Horizon Europe\r\nprogramme (Calcifer; Starting Grant agreement N◩101165631). L. Barrault\r\nacknowledges the support of the Austrian Academy of Sciences through the Doctoral Fellowship Programme (DOC) of the Austrian Academy of Sciences 27648.\r\nWhile partially funded by the European Union, views and opinions expressed\r\nare, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union\r\nnor the granting authority can be held responsible for them.","citation":{"apa":"Einramhof, L., Bugnet, L. A., Calcaferro, L. M., Barrault, L., & Das, S. B. (2026). Magneto-archeology of white dwarfs. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202659069","ieee":"L. Einramhof, L. A. Bugnet, L. M. Calcaferro, L. Barrault, and S. B. Das, “Magneto-archeology of white dwarfs,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.","ama":"Einramhof L, Bugnet LA, Calcaferro LM, Barrault L, Das SB. Magneto-archeology of white dwarfs. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202659069","ista":"Einramhof L, Bugnet LA, Calcaferro LM, Barrault L, Das SB. 2026. Magneto-archeology of white dwarfs. Astronomy & Astrophysics. 708, L14.","short":"L. Einramhof, L.A. Bugnet, L.M. Calcaferro, L. Barrault, S.B. Das, Astronomy & Astrophysics 708 (2026).","mla":"Einramhof, Lukas, et al. “Magneto-Archeology of White Dwarfs.” Astronomy & Astrophysics, vol. 708, L14, EDP Sciences, 2026, doi:10.1051/0004-6361/202659069.","chicago":"Einramhof, Lukas, Lisa Annabelle Bugnet, L. M. Calcaferro, Lucas Barrault, and S. B. Das. “Magneto-Archeology of White Dwarfs.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202659069."},"year":"2026","_id":"22663","status":"public","researchdata_availability":"yes","oa_version":"Published Version","external_id":{"arxiv":["2601.15203"]},"intvolume":" 708","file":[{"file_id":"22671","success":1,"file_name":"2026_AstronomyAstrophysics_Einramhof.pdf","date_created":"2026-08-11T05:46:02Z","file_size":3739424,"relation":"main_file","access_level":"open_access","checksum":"61edee776603d7b879b06b3ea8d2bc89","date_updated":"2026-08-11T05:46:02Z","content_type":"application/pdf","creator":"dernst"}],"dataavailabilitystatement":"We used MESA version 24.08.1. All inlists and relevant files are available on Zenodo at https://doi.org/10.5281/zenodo.19232789"},{"_id":"22648","status":"public","researchdata_availability":"no","oa_version":"Published Version","das_tickbox":"0","day":"04","arxiv":1,"acknowledgement":"M.L. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie SkƂodowska-Curie Grant Agreement No. 101034413. T.D. acknowledges the support of NSF funds CCF-2437030 and DMS-2301360. The authors would like to thank the anonymous reviewers for their careful reading of the paper. Their feedback significantly improved the quality of the article. T.D. and M.L. would like to acknowledge many thought-provoking discussions with Marian Mrozek on combinatorial dynamical systems and their continuations. M.S.T. would like to thank Álvaro SĂĄnchez for insightful discussions about representation theory. Open access funding provided by Institute of Science and Technology (IST Austria).","citation":{"mla":"Dey, Tamal K., et al. “Conley-Morse Persistence Barcode: A Homological Signature of Combinatorial Bifurcations.” Foundations of Computational Mathematics, Springer, 2026, doi:10.1007/s10208-026-09766-6.","short":"T.K. Dey, M. LipiƄski, M. Soriano Trigueros, Foundations of Computational Mathematics (2026).","chicago":"Dey, Tamal K., MichaƂ LipiƄski, and Manuel Soriano Trigueros. “Conley-Morse Persistence Barcode: A Homological Signature of Combinatorial Bifurcations.” Foundations of Computational Mathematics. Springer, 2026. https://doi.org/10.1007/s10208-026-09766-6.","apa":"Dey, T. K., LipiƄski, M., & Soriano Trigueros, M. (2026). Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics. Springer. https://doi.org/10.1007/s10208-026-09766-6","ieee":"T. K. Dey, M. LipiƄski, and M. Soriano Trigueros, “Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations,” Foundations of Computational Mathematics. Springer, 2026.","ama":"Dey TK, LipiƄski M, Soriano Trigueros M. Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics. 2026. doi:10.1007/s10208-026-09766-6","ista":"Dey TK, LipiƄski M, Soriano Trigueros M. 2026. Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations. Foundations of Computational Mathematics."},"year":"2026","publisher":"Springer","external_id":{"arxiv":["2504.17105"]},"date_updated":"2026-08-11T06:13:33Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Bifurcation characterizes the qualitative changes in parameterized dynamical systems and is one of the major topics in the field. In this work, we study combinatorial bifurcations within the framework of combinatorial dynamical systems—a young but already well-established theory. We introduce the Conley–Morse persistence barcode, a compact algebraic descriptor of combinatorial bifurcations. This barcode captures structural changes in a dynamical system at the level of Morse decompositions and provides a characterization of the nature of observed transitions in terms of the Conley index. The construction of the Conley–Morse persistence barcode builds upon ideas from topological persistence. Specifically, we consider a persistence module obtained from the Conley index of invariant sets indexed over a poset. Using gentle algebras, we prove that this module decomposes into simple intervals (bars) and compute them by adapting the zigzag persistence algorithm to our purpose.","lang":"eng"}],"ec_funded":1,"ddc":["500"],"PlanS_conform":"1","has_accepted_license":"1","OA_type":"hybrid","date_published":"2026-08-04T00:00:00Z","article_type":"original","fulldoi":"https://doi.org/10.1007/s10208-026-09766-6","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"keyword":["Multivector field","Conley index","Morse decomposition","Bifurcation","Continuation","Zigzag persistence","Persistence barcode","Gentle algebra"],"OA_place":"publisher","language":[{"iso":"eng"}],"department":[{"_id":"HeEd"}],"publication_status":"epub_ahead","month":"08","supplementarymaterial":"yes","date_created":"2026-08-05T06:11:30Z","article_processing_charge":"Yes (via OA deal)","project":[{"grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"}],"quality_controlled":"1","corr_author":"1","scopus_import":"1","publication":"Foundations of Computational Mathematics","author":[{"first_name":"Tamal K.","last_name":"Dey","full_name":"Dey, Tamal K."},{"orcid":"0000-0001-9789-9750","first_name":"MichaƂ","full_name":"LipiƄski, MichaƂ","id":"dfffb474-4317-11ee-8f5c-fe3fc95a425e","last_name":"LipiƄski"},{"first_name":"Manuel","orcid":"0000-0003-2449-1433","id":"15ebd7cf-15bf-11ee-aebd-bb4bb5121ea8","last_name":"Soriano Trigueros","full_name":"Soriano Trigueros, Manuel"}],"publication_identifier":{"eissn":["1615-3383"],"issn":["1615-3375"]},"title":"Conley-Morse persistence barcode: A homological signature of combinatorial bifurcations","oa":1,"doi":"10.1007/s10208-026-09766-6","main_file_link":[{"url":"https://doi.org/10.1007/s10208-026-09766-6","open_access":"1"}],"type":"journal_article"},{"researchdata_availability":"yes","_id":"22677","status":"public","oa_version":"Published Version","das_tickbox":"1","day":"30","publisher":"Elsevier","acknowledgement":"Joshua Castro acknowledges the support and funding of the Swiss Government Excellence Scholarships (ESKAS-Nr: 2022.0416) and the Doc. Mobility program by the University of Fribourg. Catriona Fyffe acknowledges support from the Marie SkƂodowska-Curie Action project EPIC, which was funded by the European Union (grant number 101105480). Francesca Pellicciotti and Vinisha Varghese acknowledge support from the SNSF-funded PASTURE project, grant no. 202604. Emily Potter was jointly funded by a Leverhulme Trust ECR fellowship and NERC grant NE/X004031/1. We thank Miguel Vargas from the Universidad Nacional San Antonio Abad del Cusco for providing the validation points dataset used in this work.","year":"2026","citation":{"chicago":"Castro, Joshua, Catriona Louise Fyffe, Thomas Shaw, Evan Miles, Emily Potter, Martin Hoelzle, Vinisha Varghese, and Francesca Pellicciotti. “Andean Wetlands: Seasonal Variability and Their Interactions with the Cryosphere.” Journal of Hydrology: Regional Studies. Elsevier, 2026. https://doi.org/10.1016/j.ejrh.2026.103808.","mla":"Castro, Joshua, et al. “Andean Wetlands: Seasonal Variability and Their Interactions with the Cryosphere.” Journal of Hydrology: Regional Studies, vol. 67, 103808, Elsevier, 2026, doi:10.1016/j.ejrh.2026.103808.","short":"J. Castro, C.L. Fyffe, T. Shaw, E. Miles, E. Potter, M. Hoelzle, V. Varghese, F. Pellicciotti, Journal of Hydrology: Regional Studies 67 (2026).","ama":"Castro J, Fyffe CL, Shaw T, et al. Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. 2026;67. doi:10.1016/j.ejrh.2026.103808","ista":"Castro J, Fyffe CL, Shaw T, Miles E, Potter E, Hoelzle M, Varghese V, Pellicciotti F. 2026. Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. 67, 103808.","apa":"Castro, J., Fyffe, C. L., Shaw, T., Miles, E., Potter, E., Hoelzle, M., 
 Pellicciotti, F. (2026). Andean wetlands: Seasonal variability and their interactions with the cryosphere. Journal of Hydrology: Regional Studies. Elsevier. https://doi.org/10.1016/j.ejrh.2026.103808","ieee":"J. Castro et al., “Andean wetlands: Seasonal variability and their interactions with the cryosphere,” Journal of Hydrology: Regional Studies, vol. 67. Elsevier, 2026."},"dataavailabilitystatement":"Research Data and script is available in https://doi.org/10.5281/zenodo.18508189.","intvolume":" 67","file":[{"creator":"dernst","content_type":"application/pdf","date_updated":"2026-08-11T06:45:46Z","access_level":"open_access","checksum":"6a6545fc11b6c7948cdede877d19e3f3","relation":"main_file","file_size":13155535,"date_created":"2026-08-11T06:45:46Z","file_name":"2026_JourHydrology_Castro.pdf","success":1,"file_id":"22680"}],"date_updated":"2026-08-11T06:48:28Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2026-08-11T06:45:46Z","abstract":[{"lang":"eng","text":"Study region: The Vilcanota Urubamba Basin in southern Peru includes fragile wetland ecosystems that play a key role in mountain hydrology and support grazing for Andean communities.\r\nStudy focus: Mapping of wetlands variability is missing, limiting our understanding of their characteristics, seasonality and link with the cryosphere. We characterise wetland distribution, seasonality and persistence and evaluate their spatial association with glaciers and seasonal snow. Using Landsat 7 and 8 imagery, we build three-month seasonal land cover maps from 2013 to 2022 using a Random Forest classification and an Albedo Retrieval approach.\r\nNew hydrological insights for the region: Wetland area decreases by 38% from the end of the wet season (October to December) to the end of the dry season (July to September). Pixel transitions indicate that wetlands primarily transform to and from agricultural and pasture lands. Highly persistent wetlands are located above 4600 m a.s.l. and closer to glaciers than less persistent wetlands. We identified three wetland seasonal drying patterns. Basins with delayed and slow dry-out wetlands were more common at higher elevations but were not always in glacierised catchments, suggesting meltwater may maintain wetlands in the early dry season. We provide the first large-scale picture of wetland seasonality, and the basis for modelling the processes that sustain wetlands in tropical high mountains."}],"OA_type":"gold","has_accepted_license":"1","date_published":"2026-07-30T00:00:00Z","ddc":["550"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","fulldoi":"https://doi.org/10.1016/j.ejrh.2026.103808","DOAJ_listed":"1","OA_place":"publisher","publication_status":"published","department":[{"_id":"FrPe"}],"volume":67,"language":[{"iso":"eng"}],"month":"07","article_processing_charge":"Yes","date_created":"2026-08-11T06:19:46Z","supplementarymaterial":"yes","project":[{"_id":"bdbe6627-d553-11ed-ba76-b5c9eedf278f","name":"ExPloring the ecohydrological Impacts of a changing Cryosphere in the Peruvian Andes","grant_number":"101105480"}],"quality_controlled":"1","scopus_import":"1","publication":"Journal of Hydrology: Regional Studies","author":[{"last_name":"Castro","full_name":"Castro, Joshua","first_name":"Joshua"},{"full_name":"Fyffe, Catriona Louise","last_name":"Fyffe","id":"001b0422-8d15-11ed-bc51-cab6c037a228","first_name":"Catriona Louise"},{"first_name":"Thomas","orcid":"0000-0001-7640-6152","last_name":"Shaw","id":"3caa3f91-1f03-11ee-96ce-e0e553054d6e","full_name":"Shaw, Thomas"},{"full_name":"Miles, Evan","last_name":"Miles","first_name":"Evan"},{"first_name":"Emily","full_name":"Potter, Emily","last_name":"Potter"},{"first_name":"Martin","full_name":"Hoelzle, Martin","last_name":"Hoelzle"},{"first_name":"Vinisha","full_name":"Varghese, Vinisha","last_name":"Varghese"},{"first_name":"Francesca","orcid":"0000-0002-5554-8087","full_name":"Pellicciotti, Francesca","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti"}],"oa":1,"title":"Andean wetlands: Seasonal variability and their interactions with the cryosphere","publication_identifier":{"eissn":["2214-5818"]},"type":"journal_article","doi":"10.1016/j.ejrh.2026.103808","article_number":"103808"},{"quality_controlled":"1","date_created":"2026-08-11T06:19:19Z","supplementarymaterial":"yes","article_processing_charge":"Yes","month":"07","department":[{"_id":"IlCa"}],"volume":1006,"language":[{"iso":"eng"}],"publication_status":"published","article_number":"L57","doi":"10.3847/2041-8213/ae77f3","type":"journal_article","publication_identifier":{"issn":["2041-8205"],"eissn":["2041-8213"]},"oa":1,"title":"TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy","author":[{"first_name":"Robert","last_name":"Stein","full_name":"Stein, Robert"},{"first_name":"Jonathan","last_name":"Carney","full_name":"Carney, Jonathan"},{"last_name":"Ward","full_name":"Ward, Charlotte","first_name":"Charlotte"},{"first_name":"Raffaella","full_name":"Margutti, Raffaella","last_name":"Margutti"},{"first_name":"Xander J.","last_name":"Hall","full_name":"Hall, Xander J."},{"first_name":"Itai","full_name":"Sfaradi, Itai","last_name":"Sfaradi"},{"first_name":"Igor","full_name":"Andreoni, Igor","last_name":"Andreoni"},{"full_name":"Charalampopoulos, Panos","last_name":"Charalampopoulos","first_name":"Panos"},{"full_name":"Chornock, Ryan","last_name":"Chornock","first_name":"Ryan"},{"first_name":"Suvi","last_name":"Gezari","full_name":"Gezari, Suvi"},{"first_name":"Geoffrey","full_name":"Mo, Geoffrey","last_name":"Mo"},{"full_name":"Yao, Yuhan","last_name":"Yao","first_name":"Yuhan"},{"last_name":"Anumarlapudi","full_name":"Anumarlapudi, Akash","first_name":"Akash"},{"full_name":"Bellm, Eric C.","last_name":"Bellm","first_name":"Eric C."},{"first_name":"Joshua S.","full_name":"Bloom, Joshua S.","last_name":"Bloom"},{"full_name":"Busmann, Malte","last_name":"Busmann","first_name":"Malte"},{"orcid":"0000-0002-4770-5388","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","last_name":"Caiazzo","full_name":"Caiazzo, Ilaria"},{"last_name":"Cenko","full_name":"Cenko, S. Bradley","first_name":"S. Bradley"},{"first_name":"Matthew J.","last_name":"Graham","full_name":"Graham, Matthew J."},{"full_name":"Groom, Steven L.","last_name":"Groom","first_name":"Steven L."},{"full_name":"Gruen, Daniel","last_name":"Gruen","first_name":"Daniel"},{"first_name":"Erica","last_name":"Hammerstein","full_name":"Hammerstein, Erica"},{"full_name":"Kaiser, Benjamin C.","last_name":"Kaiser","first_name":"Benjamin C."},{"first_name":"Mansi M.","full_name":"Kasliwal, Mansi M.","last_name":"Kasliwal"},{"last_name":"O’Connor","full_name":"O’Connor, Brendan","first_name":"Brendan"},{"full_name":"Palmese, Antonella","last_name":"Palmese","first_name":"Antonella"},{"full_name":"Purdum, Josiah","last_name":"Purdum","first_name":"Josiah"},{"first_name":"Jillian C.","full_name":"Rastinejad, Jillian C.","last_name":"Rastinejad"},{"first_name":"Reed","last_name":"Riddle","full_name":"Riddle, Reed"},{"last_name":"Rusholme","full_name":"Rusholme, Ben","first_name":"Ben"},{"full_name":"Sollerman, Jesper","last_name":"Sollerman","first_name":"Jesper"},{"full_name":"Somalwar, Jean J.","last_name":"Somalwar","first_name":"Jean J."},{"first_name":"Sylvain","full_name":"Veilleux, Sylvain","last_name":"Veilleux"}],"publication":"The Astrophysical Journal Letters","scopus_import":"1","file":[{"relation":"main_file","access_level":"open_access","checksum":"42b983f18497bb644f422709de7dc68c","creator":"dernst","date_updated":"2026-08-11T07:45:16Z","content_type":"application/pdf","file_id":"22682","success":1,"file_size":10322417,"date_created":"2026-08-11T07:45:16Z","file_name":"2026_AstrophysicalJourLetters_Stein.pdf"}],"intvolume":" 1006","external_id":{"arxiv":["2602.10180"]},"issue":"2","citation":{"chicago":"Stein, Robert, Jonathan Carney, Charlotte Ward, Raffaella Margutti, Xander J. Hall, Itai Sfaradi, Igor Andreoni, et al. “TDE 2025abcr: A Tidal Disruption Event in the Outskirts of a Massive Galaxy.” The Astrophysical Journal Letters. IOP Publishing, 2026. https://doi.org/10.3847/2041-8213/ae77f3.","mla":"Stein, Robert, et al. “TDE 2025abcr: A Tidal Disruption Event in the Outskirts of a Massive Galaxy.” The Astrophysical Journal Letters, vol. 1006, no. 2, L57, IOP Publishing, 2026, doi:10.3847/2041-8213/ae77f3.","short":"R. Stein, J. Carney, C. Ward, R. Margutti, X.J. Hall, I. Sfaradi, I. Andreoni, P. Charalampopoulos, R. Chornock, S. Gezari, G. Mo, Y. Yao, A. Anumarlapudi, E.C. Bellm, J.S. Bloom, M. Busmann, I. Caiazzo, S.B. Cenko, M.J. Graham, S.L. Groom, D. Gruen, E. Hammerstein, B.C. Kaiser, M.M. Kasliwal, B. O’Connor, A. Palmese, J. Purdum, J.C. Rastinejad, R. Riddle, B. Rusholme, J. Sollerman, J.J. Somalwar, S. Veilleux, The Astrophysical Journal Letters 1006 (2026).","ista":"Stein R, Carney J, Ward C, Margutti R, Hall XJ, Sfaradi I, Andreoni I, Charalampopoulos P, Chornock R, Gezari S, Mo G, Yao Y, Anumarlapudi A, Bellm EC, Bloom JS, Busmann M, Caiazzo I, Cenko SB, Graham MJ, Groom SL, Gruen D, Hammerstein E, Kaiser BC, Kasliwal MM, O’Connor B, Palmese A, Purdum J, Rastinejad JC, Riddle R, Rusholme B, Sollerman J, Somalwar JJ, Veilleux S. 2026. TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. 1006(2), L57.","ama":"Stein R, Carney J, Ward C, et al. TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. 2026;1006(2). doi:10.3847/2041-8213/ae77f3","ieee":"R. Stein et al., “TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy,” The Astrophysical Journal Letters, vol. 1006, no. 2. IOP Publishing, 2026.","apa":"Stein, R., Carney, J., Ward, C., Margutti, R., Hall, X. J., Sfaradi, I., 
 Veilleux, S. (2026). TDE 2025abcr: A tidal disruption event in the outskirts of a massive galaxy. The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae77f3"},"year":"2026","acknowledgement":"We thank Muryel Guolo, Dan Perley, and Carl Rodriguez for the fruitful discussions about off-nuclear TDEs.\r\n\r\nBased on observations obtained with the Samuel Oschin Telescope 48-inch and the 60-inch Telescope at the Palomar Observatory as part of the ZTF project. ZTF is supported by the National Science Foundation under award #2407588 and a partnership including Caltech, USA; Caltech/IPAC, USA; University of Maryland, USA; University of California, Berkeley, USA; Cornell University, USA; Drexel University, USA; University of North Carolina at Chapel Hill, USA; Institute of Science and Technology, Austria; National Central University, Taiwan, and the German Center for Astrophysics (DZA), Germany. Operations are conducted by Caltech’s Optical Observatory (COO), Caltech/IPAC, and the University of Washington at Seattle, USA.\r\n\r\nSED Machine is based upon work supported by the National Science Foundation under grant No. 1106171.\r\n\r\nThe Gordon and Betty Moore Foundation, through both the Data-Driven Investigator Program and a dedicated grant, provided critical funding for SkyPortal.\r\n\r\nThese results were obtained with the use of LDT, owned and operated by the Lowell Observatory\r\n\r\nSome of the data presented herein were obtained at Keck Observatory, which is a private 501(c)3 nonprofit organization operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors wish to recognize and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the Native Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain.\r\n\r\nA major upgrade of the Kast spectrograph on the Shane 3 m telescope at Lick Observatory, led by Brad Holden, was made possible through gifts from the Heising-Simons Foundation, William and Marina Kast, and the University of California Observatories. Research at Lick Observatory is partially supported by a generous gift from Google.\r\n\r\nThis work is based (in part) on observations made with NOT, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku and the University of Oslo, representing Denmark, Finland and Norway, the University of Iceland and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias under NOT programmes 72-504. The NOT data presented here were obtained with ALFOSC, which is provided by the Instituto de Astrofisica de Andalucia (IAA) under a joint agreement with the University of Copenhagen and NOT.\r\n\r\nThis work made use of data supplied by the UK Swift Science Data Centre at the University of Leicester.\r\n\r\nThis paper contains data obtained at the Wendelstein Observatory of the Ludwig-Maximilians University Munich. We thank Christoph Ries for carrying out the observations. Funded in part by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC-2094/2—390783311.\r\n\r\nThe national facility capability for SkyMapper has been funded through ARC LIEF grant LE130100104 from the Australian Research Council, awarded to the University of Sydney, the Australian National University, Swinburne University of Technology, the University of Queensland, the University of Western Australia, the University of Melbourne, Curtin University of Technology, Monash University, and the Australian Astronomical Observatory. SkyMapper is owned and operated by The Australian National University’s Research School of Astronomy and Astrophysics. The survey data were processed and provided by the SkyMapper Team at ANU. The SkyMapper node of the All-Sky Virtual Observatory (ASVO) is hosted at the National Computational Infrastructure (NCI). Development and support of the SkyMapper node of the ASVO has been funded in part by Astronomy Australia Limited (AAL) and the Australian Government through the Commonwealth’s Education Investment Fund (EIF) and National Collaborative Research Infrastructure Strategy (NCRIS), particularly the National eResearch Collaboration Tools and Resources (NeCTAR) and the Australian National Data Service Projects (ANDS).\r\n\r\nThe National Radio Astronomy Observatory (NRAO) is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. We thank the NRAO for carrying out the Karl G. Jansky VLA observation.\r\n\r\nNote Added - Shortly before this work was accepted, we became aware of a later preprint by K. Patra et al. (2026). The work reaches many similar conclusions to our own, and presents additional JWST data of TDE 2025abcr. We also thank the authors for highlighting a typo on an earlier version of this manuscript, with the projected offset incorrectly given as 10.3 kpc rather than 9.3 kpc.\r\n\r\nFacilities: PO:1.2m - Palomar Observatory's 1.2 meter Samuel Oschin Telescope (ZTF), Hale - Palomar Observatory's 5.1m Hale Telescope (protoCerberus), Keck:I - KECK I Telescope (LRIS), LDT - (DeVeney, LMI), NOT - Nordic Optical Telescope (ALFOSC), PO:1.5m - Palomar Observatory's 1.5 meter Telescope (SEDM), SOAR - The Southern Astrophysical Research Telescope (Goodman), Swift - Swift Gamma-Ray Burst Mission (XRT, UVOT) - , VLA - Very Large Array, WO:2m - (3KK).\r\n\r\nSoftware: astroquery (B. D. Johnson et al. 2021), emcee (D. Foreman-Mackey et al. 2013), HEASoft, galsynthspec (R. D. Stein 2025), mirar (R. D. Stein et al. 2025), prospector (B. D. Johnson et al. 2021), SCAMP (E. Bertin 2006), scarlet (P. Melchior et al. 2018), Source Extractor (E. Bertin & S. Arnouts 1996), swifttools, tdescore (R. Stein et al. 2024), uvotredux (R. D. Stein & J. Carney 2025).","publisher":"IOP Publishing","arxiv":1,"das_tickbox":"0","day":"27","oa_version":"Published Version","researchdata_availability":"no","_id":"22675","status":"public","OA_place":"publisher","DOAJ_listed":"1","article_type":"original","fulldoi":"https://doi.org/10.3847/2041-8213/ae77f3","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["520"],"PlanS_conform":"1","date_published":"2026-07-27T00:00:00Z","OA_type":"gold","has_accepted_license":"1","abstract":[{"text":"Tidal disruption events (TDEs) have traditionally been discovered in optical sky surveys through targeted searches of nuclear transients. However, it is expected that some TDEs will occur outside the galaxy nucleus, arising from wandering black holes (BHs) originating in galaxy mergers. Here, we present observations of TDE 2025abcr, the first optical TDE discovered in the outskirts of a host galaxy. The TDE was identified by a custom “off-nuclear” implementation of the machine learning classifier tdescore, which classifies new ZTF transients based on their lightcurves. Follow-up observations confirm that TDE 2025abcr is a TDE-H+He, occurring 9\r\n5 (9.3 kpc projected distance) from the nucleus of a massive galaxy (M⋆ = 1011.18±0.03M⊙) with a central BH mass of 108.82±0.65M⊙. TDE 2025abcr itself was likely disrupted by a much lighter BH (106.09±0.53M⊙, as estimated with peak luminosity scaling relations). The BH was either dynamically ejected from the nucleus or lies at the center of a very faint tidally stripped dwarf galaxy undergoing a minor merger. Late-time observations of TDE 2025abcr could confirm the origin of this apparent “wandering” BH. The rate of highly offset (≳3 kpc) TDEs can be constrained to <10% of the nuclear TDE rate, but our discovery implies that many dozens of similar sources will be detected by the Vera C. Rubin Observatory each year with resolvable offsets.","lang":"eng"}],"file_date_updated":"2026-08-11T07:45:16Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-08-11T07:45:27Z"},{"month":"07","publication_status":"published","volume":22,"language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"quality_controlled":"1","project":[{"grant_number":"101055327","name":"Understanding the evolution of continuous genomes","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00"}],"article_processing_charge":"Yes","date_created":"2026-08-11T06:19:05Z","supplementarymaterial":"yes","author":[{"first_name":"David","orcid":"0000-0002-4014-8478","id":"419049E2-F248-11E8-B48F-1D18A9856A87","last_name":"Field","full_name":"Field, David"},{"first_name":"Sean","full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","last_name":"Stankowski"},{"first_name":"Taylor","full_name":"Reiter, Taylor","last_name":"Reiter"},{"last_name":"Polechova","full_name":"Polechova, Jitka","first_name":"Jitka"},{"first_name":"Desmond","full_name":"Bradley, Desmond","last_name":"Bradley"},{"first_name":"Daniel M.","full_name":"Richardson, Daniel M.","last_name":"Richardson"},{"first_name":"Annabel","full_name":"Whibley, Annabel","last_name":"Whibley"},{"orcid":"0000-0002-4530-8469","first_name":"Arka","id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425","last_name":"Pal","full_name":"Pal, Arka"},{"orcid":"0000-0002-1145-9226","first_name":"Daria","id":"428A94B0-F248-11E8-B48F-1D18A9856A87","last_name":"Shipilina","full_name":"Shipilina, Daria"},{"full_name":"Boell, Louis","last_name":"Boell","first_name":"Louis"},{"first_name":"Melinda","orcid":"0000-0001-6118-0541","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","last_name":"Pickup","full_name":"Pickup, Melinda"},{"last_name":"Xue","full_name":"Xue, Yongbiao","first_name":"Yongbiao"},{"last_name":"Coen","full_name":"Coen, Enrico","first_name":"Enrico"},{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H"}],"publication":"PLOS Genetics","scopus_import":"1","corr_author":"1","article_number":"e1012173","type":"journal_article","doi":"10.1371/journal.pgen.1012173","title":"Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone","oa":1,"publication_identifier":{"eissn":["1553-7404"]},"pmid":1,"publisher":"Public Library of Science","year":"2026","citation":{"mla":"Field, David, et al. “Genome-Wide Cline Analysis Identifies New Locus Contributing to a Barrier to Gene Flow across an Antirrhinum Hybrid Zone.” PLOS Genetics, vol. 22, no. 7, e1012173, Public Library of Science, 2026, doi:10.1371/journal.pgen.1012173.","short":"D. Field, S. Stankowski, T. Reiter, J. Polechova, D. Bradley, D.M. Richardson, A. Whibley, A. Pal, D. Shipilina, L. Boell, M. Pickup, Y. Xue, E. Coen, N.H. Barton, PLOS Genetics 22 (2026).","chicago":"Field, David, Sean Stankowski, Taylor Reiter, Jitka Polechova, Desmond Bradley, Daniel M. Richardson, Annabel Whibley, et al. “Genome-Wide Cline Analysis Identifies New Locus Contributing to a Barrier to Gene Flow across an Antirrhinum Hybrid Zone.” PLOS Genetics. Public Library of Science, 2026. https://doi.org/10.1371/journal.pgen.1012173.","apa":"Field, D., Stankowski, S., Reiter, T., Polechova, J., Bradley, D., Richardson, D. M., 
 Barton, N. H. (2026). Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1012173","ieee":"D. Field et al., “Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone,” PLOS Genetics, vol. 22, no. 7. Public Library of Science, 2026.","ama":"Field D, Stankowski S, Reiter T, et al. Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. 2026;22(7). doi:10.1371/journal.pgen.1012173","ista":"Field D, Stankowski S, Reiter T, Polechova J, Bradley D, Richardson DM, Whibley A, Pal A, Shipilina D, Boell L, Pickup M, Xue Y, Coen E, Barton NH. 2026. Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone. PLOS Genetics. 22(7), e1012173."},"acknowledgement":"This work was supported by the Biotechnology and Biological Sciences Research Council (https://www.ukri.org/councils/bbsrc/) (grants BB/S009256/1, BB/G009325/1, BBS/E/JI/230002C, and BBS/E/J/000PR9773 to EC, and Norwich Research Park Biosciences Doctoral Training Partnership grant (https://www.jic.ac.uk/training-careers/postgraduate-opportunities/nrp-doctoral-training-partnership/) (BB/M011216/1 to DR) and European Research Council (https://erc.europa.eu/homepage) ERC Advanced Grant HaplotypeStructure (101055327 to NB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful to Monique Burrus, Christophe Andalo, Tom Ellis, Parvathy Surendranadh and members of the Barton group for interesting discussion. We are also grateful for numerous undergraduate volunteers who assisted with collecting of flowers and leaf samples in the field. Melinda Pickup passed away before the submission of the final version of this manuscript. David L Field accepts responsibility for the integrity and validity of the data collected and analyzed.","das_tickbox":"1","day":"13","oa_version":"Published Version","status":"public","_id":"22674","researchdata_availability":"yes","intvolume":" 22","file":[{"file_id":"22683","success":1,"file_name":"2026_PloSGenetics_Field.pdf","date_created":"2026-08-11T07:53:14Z","file_size":2462781,"relation":"main_file","access_level":"open_access","checksum":"3e2d3acc179f4672c49217ae4a6e237c","content_type":"application/pdf","date_updated":"2026-08-11T07:53:14Z","creator":"dernst"}],"biorxivid":1,"issue":"7","external_id":{"biorxivid":["10.1101/2025.02.17.638607"],"pmid":["42441626"]},"dataavailabilitystatement":"The raw DNA poolSeq data and RNA data have been uploaded to SRA under accession number PRJNA1232105. The A. m. m. var. pseudo majus assembly and GFF annotations have been uploaded to NCBI WGS under accession number PRJNA1232105. The A. majus reference genome V3.0 is available at the NGDC Genome Warehouse under accession number GWHBJVT00000000. The SNP KASP data and flower colour phenotyping is available on Dryad at DOI: https://doi.org/10.5061/dryad.3bk3j9kx2. The FastClines script is available at https://github.com/dfield007/fastClines, slidingWindow genome scans at https://github.com/dfield007/slidingWindows, and all other scripts for analyses and generating figures available at https://github.com/dfield007/genome_wide_clines].","abstract":[{"lang":"eng","text":"Identification of the genomic regions that contribute to reproductive isolation and how\r\nthey interact is a major goal of evolutionary genetics. Much effort has focused on\r\nlocating candidate genes and potential barrier loci by scanning genomes for regions\r\nof excess differentiation (FST). An alternative, and perhaps more robust approach, is\r\nto scan for genomic regions exhibiting steep clines in allele frequency across a hybrid\r\nzone. We develop a computationally efficient method for approximating cline parameters\r\nfor large number of loci, and apply it to genomic data from across a hybrid zone\r\nbetween flower colour varieties of Antirrhinum majus (A. m. m var. pseudomajus and\r\nA. m. m var. striatum). Most steep clines are clustered in seven genomic regions,\r\nonly four of which were present from FST scans between all pair-wise comparisons.\r\nSix of these regions carry previously identified loci that influence flower colour in the\r\nhybrid zone. The seventh region harbours a novel locus, RUBIA, modifying magenta\r\nintensity. Clines at RUBIA approached fixation on the magenta side of the hybrid\r\nzone, whilst remaining polymorphic on the yellow side. This polymorphism on the\r\nyellow side may reflect a smaller phenotypic effect of RUBIA in yellow compared\r\nto magenta genetic backgrounds. Our findings illustrate how whole-genome cline\r\nscans in hybrid zones can robustly detect genomic regions contributing to phenotypic\r\ndifferences and highlight how different reproductive barrier loci interact across the\r\ngenome."}],"file_date_updated":"2026-08-11T07:53:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-08-11T07:55:22Z","DOAJ_listed":"1","OA_place":"publisher","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1371/journal.pgen.1012173","article_type":"original","OA_type":"gold","has_accepted_license":"1","PlanS_conform":"1","date_published":"2026-07-13T00:00:00Z","ddc":["570"]},{"das_tickbox":"1","day":"01","arxiv":1,"acknowledgement":"We thank Paul Hewett for useful discussions, and Qiaoya Wu for guidance on the data presented in Q. Wu & Y. Shen (2022). ZH acknowledges financial support from NASA grants 80NSSC24K0440 and 80NSSC22K0822. PR and ZF have received funding from the HUN-REN Hungarian Research Network and were supported by the NKFIH excellence grant TKP2021-NKTA-64.","year":"2026","citation":{"apa":"BĂ©csy, B., Raffai, P., Haiman, Z., Budai, A., & Frei, Z. (2026). Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stag1367","ieee":"B. BĂ©csy, P. Raffai, Z. Haiman, A. Budai, and Z. Frei, “Statistical evidence for massive black hole recoils in active galactic nuclei,” Monthly Notices of the Royal Astronomical Society, vol. 550, no. 4. Oxford University Press, 2026.","ista":"BĂ©csy B, Raffai P, Haiman Z, Budai A, Frei Z. 2026. Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. 550(4), stag1367.","ama":"BĂ©csy B, Raffai P, Haiman Z, Budai A, Frei Z. Statistical evidence for massive black hole recoils in active galactic nuclei. Monthly Notices of the Royal Astronomical Society. 2026;550(4). doi:10.1093/mnras/stag1367","mla":"BĂ©csy, Bence, et al. “Statistical Evidence for Massive Black Hole Recoils in Active Galactic Nuclei.” Monthly Notices of the Royal Astronomical Society, vol. 550, no. 4, stag1367, Oxford University Press, 2026, doi:10.1093/mnras/stag1367.","short":"B. BĂ©csy, P. Raffai, Z. Haiman, A. Budai, Z. Frei, Monthly Notices of the Royal Astronomical Society 550 (2026).","chicago":"BĂ©csy, Bence, Peter Raffai, ZoltĂĄn Haiman, Andor Budai, and Zsolt Frei. “Statistical Evidence for Massive Black Hole Recoils in Active Galactic Nuclei.” Monthly Notices of the Royal Astronomical Society. Oxford University Press, 2026. https://doi.org/10.1093/mnras/stag1367."},"publisher":"Oxford University Press","_id":"22676","status":"public","researchdata_availability":"yes","oa_version":"Published Version","external_id":{"arxiv":["2605.04781"]},"issue":"4","file":[{"relation":"main_file","access_level":"open_access","checksum":"85a01a4e163e4d2eccebe2472cdb453f","creator":"dernst","date_updated":"2026-08-11T06:53:09Z","content_type":"application/pdf","file_id":"22681","success":1,"file_size":3792460,"date_created":"2026-08-11T06:53:09Z","file_name":"2026_MNRAS_Becsy.pdf"}],"intvolume":" 550","dataavailabilitystatement":"The data and software that support the findings of this study are openly available. The processed data sets, analysis outputs, and software are archived on Zenodo (B. BĂ©csy et al. 2026a), and are also available on GitHub (B. BĂ©csy et al. 2026b).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2026-08-11T06:53:09Z","abstract":[{"text":"We search for a population-level signature of gravitational-wave recoiling supermassive black holes: a positive correlation between dust obscuration and the magnitude of the line-of-sight velocity offset of broad emission lines relative to the host. Using the SDSS DR16 quasar catalogue, we estimate the velocity offset, $\\Delta v$, as the difference between the broad H$\\beta$ redshift and a noise-weighted redshift from narrow lines ([O iii] 5007, [O ii] 3728, and Ca ii 3934). We adopt the redshift-relative colour excess $\\Delta (g-i)$ as a proxy for dust column density. Analysing $\\sim 10^{5}$ quasars that meet basic spectral quality requirements, we find a modest but highly significant positive correlation between $|\\Delta v|$ and $\\Delta (g-i)$ (Spearman $r\\simeq 0.12$ and Pearson $r\\simeq 0.13$, with $p\\ll 10^{-10}$ in both cases). The fraction of highly obscured quasars increases with $|\\Delta v|$, indicating that the correlation is driven by a dust-reddened subpopulation. The result is robust to the choice of minimum $|\\Delta v|$ threshold and to the line redshift estimator (peak vs. centroid). As expected, the correlation is largely absent when velocity offsets are computed between narrow emission lines. We find systematic differences between redshifted and blueshifted subsamples, which may point to residual velocity biases or additional physical effects (e.g. winds, inflows, orientation-dependent obscuration, or asymmetric broad-line regions). Recoiling massive black holes provide a natural explanation for the observed correlation, but alternative scenarios should be explored. If confirmed, this would enable population-level constraints on massive black hole merger rates, recoil dynamics, and active galactic nuclei disc properties.","lang":"eng"}],"date_updated":"2026-08-11T06:55:10Z","OA_place":"publisher","DOAJ_listed":"1","ddc":["520"],"date_published":"2026-08-01T00:00:00Z","OA_type":"gold","PlanS_conform":"1","has_accepted_license":"1","fulldoi":"https://doi.org/10.1093/mnras/stag1367","article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"month":"08","department":[{"_id":"ZoHa"}],"volume":550,"language":[{"iso":"eng"}],"publication_status":"published","quality_controlled":"1","supplementarymaterial":"no","date_created":"2026-08-11T06:19:34Z","article_processing_charge":"Yes","publication":"Monthly Notices of the Royal Astronomical Society","author":[{"first_name":"Bence","full_name":"BĂ©csy, Bence","last_name":"BĂ©csy"},{"last_name":"Raffai","full_name":"Raffai, Peter","first_name":"Peter"},{"orcid":"0000-0003-3633-5403","first_name":"ZoltĂĄn","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","last_name":"Haiman","full_name":"Haiman, ZoltĂĄn"},{"last_name":"Budai","full_name":"Budai, Andor","first_name":"Andor"},{"first_name":"Zsolt","last_name":"Frei","full_name":"Frei, Zsolt"}],"scopus_import":"1","article_number":"stag1367","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"oa":1,"title":"Statistical evidence for massive black hole recoils in active galactic nuclei","doi":"10.1093/mnras/stag1367","type":"journal_article"},{"intvolume":" 8","file":[{"date_updated":"2026-07-01T06:22:15Z","content_type":"application/pdf","creator":"dernst","relation":"main_file","access_level":"open_access","checksum":"5cfd350dc64d1476063e959316dbff65","file_name":"2026_SIAMJourmathDataScience_Zhang.pdf","file_size":1210346,"date_created":"2026-07-01T06:22:15Z","file_id":"22230","success":1}],"issue":"2","external_id":{"arxiv":["2211.11368"]},"oa_version":"Published Version","researchdata_availability":"no","_id":"22228","status":"public","publisher":"SIAM","citation":{"apa":"Zhang, Y., Mondelli, M., & Venkataramanan, R. (2026). Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. SIAM. https://doi.org/10.1137/24m1702854","ieee":"Y. Zhang, M. Mondelli, and R. Venkataramanan, “Precise asymptotics for spectral methods in mixed generalized linear models,” SIAM Journal on Mathematics of Data Science, vol. 8, no. 2. SIAM, pp. 411–439, 2026.","ama":"Zhang Y, Mondelli M, Venkataramanan R. Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. 2026;8(2):411-439. doi:10.1137/24m1702854","ista":"Zhang Y, Mondelli M, Venkataramanan R. 2026. Precise asymptotics for spectral methods in mixed generalized linear models. SIAM Journal on Mathematics of Data Science. 8(2), 411–439.","mla":"Zhang, Yihan, et al. “Precise Asymptotics for Spectral Methods in Mixed Generalized Linear Models.” SIAM Journal on Mathematics of Data Science, vol. 8, no. 2, SIAM, 2026, pp. 411–39, doi:10.1137/24m1702854.","short":"Y. Zhang, M. Mondelli, R. Venkataramanan, SIAM Journal on Mathematics of Data Science 8 (2026) 411–439.","chicago":"Zhang, Yihan, Marco Mondelli, and Ramji Venkataramanan. “Precise Asymptotics for Spectral Methods in Mixed Generalized Linear Models.” SIAM Journal on Mathematics of Data Science. SIAM, 2026. https://doi.org/10.1137/24m1702854."},"year":"2026","acknowledgement":"The first and second authors were partially supported by the 2019 Lopez-Loreta prize.","das_tickbox":"0","arxiv":1,"day":"01","keyword":["spectral estimator","generalized linear models","mixed regression","high-dimensional asymptotics","random matrix theory","approximate message passing (AMP)"],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1137/24m1702854","article_type":"original","PlanS_conform":"1","date_published":"2026-06-01T00:00:00Z","has_accepted_license":"1","OA_type":"hybrid","ddc":["000"],"OA_place":"publisher","date_updated":"2026-08-12T06:23:07Z","file_date_updated":"2026-07-01T06:22:15Z","abstract":[{"text":"In a mixed generalized linear model, the goal is to learn multiple signals from unlabeled observations: each sample comes from exactly one signal, but it is not known which one. We consider the prototypical problem of estimating two statistically independent signals in a mixed generalized linear model with Gaussian covariates. Spectral methods are a popular class of estimators which output the top two eigenvectors of a suitable data-dependent matrix. However, despite the wide applicability, their design is still obtained via heuristic considerations, and the number of samples 𝑛 needed to guarantee recovery is superlinear in the signal dimension 𝑑. In this paper, we develop exact asymptotics on spectral methods in the challenging proportional regime in which 𝑛,𝑑 grow large and their ratio converges to a finite constant. This allows us optimize the design of the spectral method, and combine it with a simple linear estimator, to minimize the estimation error. Our characterization exploits a mix of tools from random matrices, free probability, and the theory of approximate message passing algorithms. Numerical simulations for mixed linear regression and phase retrieval demonstrate the advantage enabled by our analysis over existing designs of spectral methods.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"Yes (in subscription journal)","date_created":"2026-06-30T13:03:41Z","supplementarymaterial":"no","quality_controlled":"1","project":[{"_id":"059876FA-7A3F-11EA-A408-12923DDC885E","name":"Prix Lopez-Loretta 2019 - Marco Mondelli"}],"publication_status":"published","language":[{"iso":"eng"}],"volume":8,"department":[{"_id":"MaMo"}],"page":"411-439","month":"06","type":"journal_article","doi":"10.1137/24m1702854","title":"Precise asymptotics for spectral methods in mixed generalized linear models","oa":1,"publication_identifier":{"eissn":["2577-0187"]},"scopus_import":"1","corr_author":"1","mathsc":["62E20","62J05","62J12"],"author":[{"first_name":"Yihan","last_name":"Zhang","full_name":"Zhang, Yihan"},{"full_name":"Mondelli, Marco","last_name":"Mondelli","id":"27EB676C-8706-11E9-9510-7717E6697425","first_name":"Marco","orcid":"0000-0002-3242-7020"},{"full_name":"Venkataramanan, Ramji","last_name":"Venkataramanan","first_name":"Ramji"}],"publication":"SIAM Journal on Mathematics of Data Science"},{"publication_status":"published","language":[{"iso":"eng"}],"volume":20,"department":[{"_id":"JaMa"}],"page":"34-55","month":"04","article_processing_charge":"No","date_created":"2026-02-01T23:01:43Z","quality_controlled":"1","project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","grant_number":"101034413"}],"scopus_import":"1","author":[{"id":"63ff57e8-1fbb-11ee-88f2-f558ffc59cf1","last_name":"Brigati","full_name":"Brigati, Giovanni","first_name":"Giovanni"},{"first_name":"Francis","last_name":"Lörler","full_name":"Lörler, Francis"},{"first_name":"Lihan","last_name":"Wang","full_name":"Wang, Lihan"}],"publication":"Kinetic and Related Models","type":"journal_article","doi":"10.3934/krm.2025020","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2412.10890","open_access":"1"}],"title":"Hypocoercivity meets lifts","oa":1,"publication_identifier":{"eissn":["1937-5077"],"issn":["1937-5093"]},"oa_version":"Preprint","_id":"21132","status":"public","publisher":"AIMS","year":"2026","acknowledgement":"We would like to thank Andreas Eberle and Gabriel Stoltz for many helpful discussions. GB\r\nhas received funding from the European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101034413. FL wurde gefördert durch die Deutsche Forschungsgemeinschaft (DFG) im Rahmen der Exzellenzstrategie des Bundes und der LĂ€nder – GZ2047/1, Projekt-ID 390685813. LW is supported by the National Science Foundation via grant DMS-2407166. He is also indebted to the Mathematical Sciences department at Carnegie Mellon University for partly supporting his visit to Europe in July 2024. Part of this work was completed when GB and LW were visiting the Institute for Applied Mathematics in Bonn. GB and LW would like to thank IAM for their hospitality.","citation":{"chicago":"Brigati, Giovanni, Francis Lörler, and Lihan Wang. “Hypocoercivity Meets Lifts.” Kinetic and Related Models. AIMS, 2026. https://doi.org/10.3934/krm.2025020.","mla":"Brigati, Giovanni, et al. “Hypocoercivity Meets Lifts.” Kinetic and Related Models, vol. 20, AIMS, 2026, pp. 34–55, doi:10.3934/krm.2025020.","short":"G. Brigati, F. Lörler, L. Wang, Kinetic and Related Models 20 (2026) 34–55.","ista":"Brigati G, Lörler F, Wang L. 2026. Hypocoercivity meets lifts. Kinetic and Related Models. 20, 34–55.","ama":"Brigati G, Lörler F, Wang L. Hypocoercivity meets lifts. Kinetic and Related Models. 2026;20:34-55. doi:10.3934/krm.2025020","apa":"Brigati, G., Lörler, F., & Wang, L. (2026). Hypocoercivity meets lifts. Kinetic and Related Models. AIMS. https://doi.org/10.3934/krm.2025020","ieee":"G. Brigati, F. Lörler, and L. Wang, “Hypocoercivity meets lifts,” Kinetic and Related Models, vol. 20. AIMS, pp. 34–55, 2026."},"arxiv":1,"day":"01","das_tickbox":"1","intvolume":" 20","external_id":{"arxiv":["2412.10890"]},"date_updated":"2026-08-12T06:20:09Z","ec_funded":1,"abstract":[{"lang":"eng","text":"We unify the variational hypocoercivity framework established by D. Albritton, S. Armstrong, J.-C. Mourrat, and M. Novack [2], with the notion of second-order lifts of reversible diffusion processes, recently introduced by A. Eberle and the second author [30]. We give an abstract, yet fully constructive, presentation of the theory, so that it can be applied to a large class of linear kinetic equations. As this hypocoercivity technique does not twist the reference norm, we can recover accurate and sharp convergence rates in various models. Among those, adaptive Langevin dynamics (ALD) is discussed in full detail and we show that for near-quadratic potentials, with suitable choices of parameters, it is a near-optimal second-order lift of the overdamped Langevin dynamics. As a further consequence, we observe that the Generalised Langevin Equation (GLE) is also a second-order lift, as the standard (kinetic) Langevin dynamics are, of the overdamped Langevin dynamics. Then, convergence of (GLE) cannot exceed ballistic speed, i.e. the square root of the rate of the overdamped regime. We illustrate this phenomenon with explicit computations in a benchmark Gaussian case."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.3934/krm.2025020","article_type":"original","OA_type":"green","date_published":"2026-04-01T00:00:00Z","OA_place":"repository"},{"article_processing_charge":"No","date_created":"2026-01-12T11:17:06Z","quality_controlled":"1","project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","grant_number":"101034413"}],"publication_status":"published","volume":25,"language":[{"iso":"eng"}],"department":[{"_id":"HeEd"}],"page":"108-130","month":"01","type":"journal_article","doi":"10.1137/25m1739406","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2502.19369","open_access":"1"}],"oa":1,"title":"Computing a connection matrix and persistence efficiently from a morse decomposition","publication_identifier":{"issn":["1536-0040"]},"scopus_import":"1","author":[{"full_name":"Dey, Tamal K.","last_name":"Dey","first_name":"Tamal K."},{"first_name":"Andrew","full_name":"Haas, Andrew","last_name":"Haas"},{"first_name":"MichaƂ","orcid":"0000-0001-9789-9750","full_name":"LipiƄski, MichaƂ","id":"dfffb474-4317-11ee-8f5c-fe3fc95a425e","last_name":"LipiƄski"}],"publication":"SIAM Journal on Applied Dynamical Systems","intvolume":" 25","issue":"1","external_id":{"arxiv":["2502.19369"]},"oa_version":"Preprint","status":"public","_id":"20980","publisher":"SIAM","acknowledgement":"This research was supported by NSF grants DMS-2301360 and CCF-2437030 as well as from the European Union's Horizon 2020 research and innovation programme under Marie Sk\\lodowska-Curie grant 101034413.\r\n","year":"2026","citation":{"mla":"Dey, Tamal K., et al. “Computing a Connection Matrix and Persistence Efficiently from a Morse Decomposition.” SIAM Journal on Applied Dynamical Systems, vol. 25, no. 1, SIAM, 2026, pp. 108–30, doi:10.1137/25m1739406.","short":"T.K. Dey, A. Haas, M. LipiƄski, SIAM Journal on Applied Dynamical Systems 25 (2026) 108–130.","chicago":"Dey, Tamal K., Andrew Haas, and MichaƂ LipiƄski. “Computing a Connection Matrix and Persistence Efficiently from a Morse Decomposition.” SIAM Journal on Applied Dynamical Systems. SIAM, 2026. https://doi.org/10.1137/25m1739406.","apa":"Dey, T. K., Haas, A., & LipiƄski, M. (2026). Computing a connection matrix and persistence efficiently from a morse decomposition. SIAM Journal on Applied Dynamical Systems. SIAM. https://doi.org/10.1137/25m1739406","ieee":"T. K. Dey, A. Haas, and M. LipiƄski, “Computing a connection matrix and persistence efficiently from a morse decomposition,” SIAM Journal on Applied Dynamical Systems, vol. 25, no. 1. SIAM, pp. 108–130, 2026.","ama":"Dey TK, Haas A, LipiƄski M. Computing a connection matrix and persistence efficiently from a morse decomposition. SIAM Journal on Applied Dynamical Systems. 2026;25(1):108-130. doi:10.1137/25m1739406","ista":"Dey TK, Haas A, LipiƄski M. 2026. Computing a connection matrix and persistence efficiently from a morse decomposition. SIAM Journal on Applied Dynamical Systems. 25(1), 108–130."},"day":"01","arxiv":1,"fulldoi":"https://doi.org/10.1137/25m1739406","article_type":"original","date_published":"2026-01-01T00:00:00Z","OA_type":"green","ddc":["510"],"OA_place":"repository","date_updated":"2026-08-12T06:23:46Z","abstract":[{"text":"Morse decompositions partition the flows in a vector field into equivalent structures. Given such a decomposition, one can define a further summary of its flow structure by what is called a connection matrix. These matrices, a generalization of Morse boundary operators from classical Morse theory, capture the connections made by the flows among the critical structures—such as attractors, repellers, and orbits—in a vector field. Recently, in the context of combinatorial dynamics, an efficient persistence-like algorithm to compute connection matrices has been proposed in Dey, LipiƄski, Mrozek, and Slechta [SIAM J. Appl. Dyn. Syst., 23 (2024), pp. 81–97]. We show that, actually, the classical persistence algorithm with exhaustive reduction retrieves connection matrices, both simplifying the algorithm of Dey et al. and bringing the theory of persistence closer to combinatorial dynamical systems. We supplement this main result with an observation: the concept of persistence as defined for scalar fields naturally adapts to Morse decompositions whose Morse sets are filtered with a Lyapunov function. We conclude by presenting preliminary experimental results.","lang":"eng"}],"ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}]