[{"volume":186,"month":"04","scopus_import":"1","publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"oa":1,"acknowledgement":"We gratefully acknowledge the Arabidopsis Biological Resource Centre (ABRC) for providing T-DNA insertional mutants, and Prof. Remko Offringa for sharing published seeds. We thank Yuchuan Liu (Shanghai OE Biotech Co., Ltd) for help with proteomics data analysis, Xixi Zhang (IST Austria) for providing the pDONR-P4P1r-mCherry plasmid, and Yao Xiao (Technical University of Munich), Alexander Johnson (IST Austria) and Hana Semeradova (IST Austria) for helpful discussions. The study was supported by National Natural Science Foundation of China (NSFC, 31721001, 91954206, to H.-W. X.), “Ten-Thousand Talent Program” (to H.-W. X.) and Collaborative Innovation Center of Crop Stress Biology, Henan Province, and Austrian Science Fund (FWF): I 3630-B25 (to J. F.). S.T. was funded by a European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 723-2015).","author":[{"last_name":"Kong","first_name":"W","full_name":"Kong, W"},{"last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang","orcid":"0000-0002-0471-8285","full_name":"Tan, Shutang"},{"full_name":"Zhao, Q","last_name":"Zhao","first_name":"Q"},{"full_name":"Lin, DL","last_name":"Lin","first_name":"DL"},{"last_name":"Xu","first_name":"ZH","full_name":"Xu, ZH"},{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596"},{"full_name":"Xue, HW","last_name":"Xue","first_name":"HW"}],"project":[{"name":"Molecular Mechanism underlying Salicylic Acid Regulation of Endocytic Trafficking in Arabidopsis","_id":"256FEF10-B435-11E9-9278-68D0E5697425","grant_number":"723-2015"},{"grant_number":"I03630","_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF"}],"language":[{"iso":"eng"}],"page":"2003-2020","citation":{"ieee":"W. Kong <i>et al.</i>, “mRNA surveillance complex PELOTA-HBS1 eegulates phosphoinositide-sependent protein kinase1 and plant growth,” <i>Plant Physiology</i>, vol. 186, no. 4. American Society of Plant Biologists, pp. 2003–2020, 2021.","mla":"Kong, W., et al. “MRNA Surveillance Complex PELOTA-HBS1 Eegulates Phosphoinositide-Sependent Protein Kinase1 and Plant Growth.” <i>Plant Physiology</i>, vol. 186, no. 4, American Society of Plant Biologists, 2021, pp. 2003–20, doi:<a href=\"https://doi.org/10.1093/plphys/kiab199\">10.1093/plphys/kiab199</a>.","ama":"Kong W, Tan S, Zhao Q, et al. mRNA surveillance complex PELOTA-HBS1 eegulates phosphoinositide-sependent protein kinase1 and plant growth. <i>Plant Physiology</i>. 2021;186(4):2003-2020. doi:<a href=\"https://doi.org/10.1093/plphys/kiab199\">10.1093/plphys/kiab199</a>","apa":"Kong, W., Tan, S., Zhao, Q., Lin, D., Xu, Z., Friml, J., &#38; Xue, H. (2021). mRNA surveillance complex PELOTA-HBS1 eegulates phosphoinositide-sependent protein kinase1 and plant growth. <i>Plant Physiology</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1093/plphys/kiab199\">https://doi.org/10.1093/plphys/kiab199</a>","ista":"Kong W, Tan S, Zhao Q, Lin D, Xu Z, Friml J, Xue H. 2021. mRNA surveillance complex PELOTA-HBS1 eegulates phosphoinositide-sependent protein kinase1 and plant growth. Plant Physiology. 186(4), 2003–2020.","chicago":"Kong, W, Shutang Tan, Q Zhao, DL Lin, ZH Xu, Jiří Friml, and HW Xue. “MRNA Surveillance Complex PELOTA-HBS1 Eegulates Phosphoinositide-Sependent Protein Kinase1 and Plant Growth.” <i>Plant Physiology</i>. American Society of Plant Biologists, 2021. <a href=\"https://doi.org/10.1093/plphys/kiab199\">https://doi.org/10.1093/plphys/kiab199</a>.","short":"W. Kong, S. Tan, Q. Zhao, D. Lin, Z. Xu, J. Friml, H. Xue, Plant Physiology 186 (2021) 2003–2020."},"isi":1,"article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.1093/plphys/kiab199","open_access":"1"}],"day":"30","quality_controlled":"1","publication":"Plant Physiology","intvolume":"       186","abstract":[{"text":"The quality control system for messenger RNA (mRNA) is fundamental for cellular activities in eukaryotes. To elucidate the molecular mechanism of 3'-Phosphoinositide-Dependent Protein Kinase1 (PDK1), a master regulator that is essential throughout eukaryotic growth and development, we employed a forward genetic approach to screen for suppressors of the loss-of-function T-DNA insertion double mutant pdk1.1 pdk1.2 in Arabidopsis thaliana. Notably, the severe growth attenuation of pdk1.1 pdk1.2 was rescued by sop21 (suppressor of pdk1.1 pdk1.2), which harbours a loss-of-function mutation in PELOTA1 (PEL1). PEL1 is a homologue of mammalian PELOTA and yeast (Saccharomyces cerevisiae) DOM34p, which each form a heterodimeric complex with the GTPase HBS1 (HSP70 SUBFAMILY B SUPPRESSOR1, also called SUPERKILLER PROTEIN7, SKI7), a protein that is responsible for ribosomal rescue and thereby assures the quality and fidelity of mRNA molecules during translation. Genetic analysis further revealed that a dysfunctional PEL1-HBS1 complex failed to degrade the T-DNA-disrupted PDK1 transcripts, which were truncated but functional, and thus rescued the growth and developmental defects of pdk1.1 pdk1.2. Our studies demonstrated the functionality of a homologous PELOTA-HBS1 complex and identified its essential regulatory role in plants, providing insights into the mechanism of mRNA quality control.","lang":"eng"}],"publication_status":"published","title":"mRNA surveillance complex PELOTA-HBS1 eegulates phosphoinositide-sependent protein kinase1 and plant growth","ddc":["580"],"issue":"4","pmid":1,"year":"2021","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","type":"journal_article","article_type":"original","publisher":"American Society of Plant Biologists","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-03T13:28:20Z","status":"public","date_published":"2021-04-30T00:00:00Z","department":[{"_id":"JiFr"}],"external_id":{"isi":["000703922000025"],"pmid":["33930167"]},"date_updated":"2026-06-18T19:48:17Z","doi":"10.1093/plphys/kiab199","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"oa_version":"Published Version","_id":"9368"},{"publication":"Evolution","intvolume":"        75","abstract":[{"lang":"eng","text":"If there are no constraints on the process of speciation, then the number of species might be expected to match the number of available niches and this number might be indefinitely large. One possible constraint is the opportunity for allopatric divergence. In 1981, Felsenstein used a simple and elegant model to ask if there might also be genetic constraints. He showed that progress towards speciation could be described by the build‐up of linkage disequilibrium among divergently selected loci and between these loci and those contributing to other forms of reproductive isolation. Therefore, speciation is opposed by recombination, because it tends to break down linkage disequilibria. Felsenstein then introduced a crucial distinction between “two‐allele” models, which are subject to this effect, and “one‐allele” models, which are free from the recombination constraint. These fundamentally important insights have been the foundation for both empirical and theoretical studies of speciation ever since."}],"title":"Homage to Felsenstein 1981, or why are there so few/many species?","publication_status":"published","day":"19","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://onlinelibrary.wiley.com/doi/10.1111/evo.14235"}],"author":[{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."},{"last_name":"Servedio","first_name":"Maria R.","full_name":"Servedio, Maria R."},{"first_name":"Carole M.","last_name":"Smadja","full_name":"Smadja, Carole M."},{"first_name":"Claudia","last_name":"Bank","full_name":"Bank, Claudia"},{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"},{"full_name":"Flaxman, Samuel M.","first_name":"Samuel M.","last_name":"Flaxman"},{"first_name":"Tatiana","last_name":"Giraud","full_name":"Giraud, Tatiana"},{"full_name":"Hopkins, Robin","last_name":"Hopkins","first_name":"Robin"},{"full_name":"Larson, Erica L.","first_name":"Erica L.","last_name":"Larson"},{"first_name":"Martine E.","last_name":"Maan","full_name":"Maan, Martine E."},{"full_name":"Meier, Joana","first_name":"Joana","last_name":"Meier"},{"first_name":"Richard","last_name":"Merrill","full_name":"Merrill, Richard"},{"full_name":"Noor, Mohamed A. F.","last_name":"Noor","first_name":"Mohamed A. F."},{"full_name":"Ortiz‐Barrientos, Daniel","first_name":"Daniel","last_name":"Ortiz‐Barrientos"},{"first_name":"Anna","last_name":"Qvarnström","full_name":"Qvarnström, Anna"}],"language":[{"iso":"eng"}],"page":"978-988","citation":{"short":"R.K. Butlin, M.R. Servedio, C.M. Smadja, C. Bank, N.H. Barton, S.M. Flaxman, T. Giraud, R. Hopkins, E.L. Larson, M.E. Maan, J. Meier, R. Merrill, M.A.F. Noor, D. Ortiz‐Barrientos, A. Qvarnström, Evolution 75 (2021) 978–988.","ama":"Butlin RK, Servedio MR, Smadja CM, et al. Homage to Felsenstein 1981, or why are there so few/many species? <i>Evolution</i>. 2021;75(5):978-988. doi:<a href=\"https://doi.org/10.1111/evo.14235\">10.1111/evo.14235</a>","apa":"Butlin, R. K., Servedio, M. R., Smadja, C. M., Bank, C., Barton, N. H., Flaxman, S. M., … Qvarnström, A. (2021). Homage to Felsenstein 1981, or why are there so few/many species? <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.14235\">https://doi.org/10.1111/evo.14235</a>","ista":"Butlin RK, Servedio MR, Smadja CM, Bank C, Barton NH, Flaxman SM, Giraud T, Hopkins R, Larson EL, Maan ME, Meier J, Merrill R, Noor MAF, Ortiz‐Barrientos D, Qvarnström A. 2021. Homage to Felsenstein 1981, or why are there so few/many species? Evolution. 75(5), 978–988.","chicago":"Butlin, Roger K., Maria R. Servedio, Carole M. Smadja, Claudia Bank, Nicholas H Barton, Samuel M. Flaxman, Tatiana Giraud, et al. “Homage to Felsenstein 1981, or Why Are There so Few/Many Species?” <i>Evolution</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/evo.14235\">https://doi.org/10.1111/evo.14235</a>.","ieee":"R. K. Butlin <i>et al.</i>, “Homage to Felsenstein 1981, or why are there so few/many species?,” <i>Evolution</i>, vol. 75, no. 5. Wiley, pp. 978–988, 2021.","mla":"Butlin, Roger K., et al. “Homage to Felsenstein 1981, or Why Are There so Few/Many Species?” <i>Evolution</i>, vol. 75, no. 5, Wiley, 2021, pp. 978–88, doi:<a href=\"https://doi.org/10.1111/evo.14235\">10.1111/evo.14235</a>."},"isi":1,"article_processing_charge":"No","oa":1,"acknowledgement":"RKB was funded by the Natural Environment Research Council (NE/P012272/1 & NE/P001610/1), the European Research Council (693030 BARRIERS), and the Swedish Research Council (VR) (2018‐03695). MRS was funded by the National Science Foundation (Grant No. DEB1939290).","publication_identifier":{"eissn":["1558-5646"],"issn":["0014-3820"]},"volume":75,"scopus_import":"1","month":"04","oa_version":"Published Version","_id":"9374","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1111/evo.14235","external_id":{"isi":["000647224000001"]},"date_updated":"2026-06-18T19:48:42Z","department":[{"_id":"NiBa"}],"status":"public","date_published":"2021-04-19T00:00:00Z","date_created":"2021-05-06T04:34:47Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["Genetics","Ecology","Evolution","Behavior and Systematics","General Agricultural and Biological Sciences"],"type":"journal_article","article_type":"original","publisher":"Wiley","ddc":["570"],"issue":"5","year":"2021","license":"https://creativecommons.org/licenses/by/4.0/"},{"day":"21","quality_controlled":"1","abstract":[{"lang":"eng","text":"Genetic variation segregates as linked sets of variants, or haplotypes. Haplotypes and linkage are central to genetics and underpin virtually all genetic and selection analysis. And yet, genomic data often lack haplotype information, due to constraints in sequencing technologies. Here we present “haplotagging”, a simple, low-cost linked-read sequencing technique that allows sequencing of hundreds of individuals while retaining linkage information. We apply haplotagging to construct megabase-size haplotypes for over 600 individual butterflies (Heliconius erato and H. melpomene), which form overlapping hybrid zones across an elevational gradient in Ecuador. Haplotagging identifies loci controlling distinctive high- and lowland wing color patterns. Divergent haplotypes are found at the same major loci in both species, while chromosome rearrangements show no parallelism. Remarkably, in both species the geographic clines for the major wing pattern loci are displaced by 18 km, leading to the rise of a novel hybrid morph in the centre of the hybrid zone. We propose that shared warning signalling (Müllerian mimicry) may couple the cline shifts seen in both species, and facilitate the parallel co-emergence of a novel hybrid morph in both co-mimetic species. Our results show the power of efficient haplotyping methods when combined with large-scale sequencing data from natural populations."}],"intvolume":"       118","publication":"Proceedings of the National Academy of Sciences of the United States of America","title":"Haplotype tagging reveals parallel formation of hybrid races in two butterfly species","publication_status":"published","has_accepted_license":"1","publication_identifier":{"eissn":["0027-8424"]},"month":"06","scopus_import":"1","volume":118,"language":[{"iso":"eng"}],"author":[{"first_name":"Joana I.","last_name":"Meier","full_name":"Meier, Joana I."},{"full_name":"Salazar, Patricio A.","last_name":"Salazar","first_name":"Patricio A."},{"last_name":"Kučka","first_name":"Marek","full_name":"Kučka, Marek"},{"last_name":"Davies","first_name":"Robert William","full_name":"Davies, Robert William"},{"full_name":"Dréau, Andreea","last_name":"Dréau","first_name":"Andreea"},{"full_name":"Aldás, Ismael","first_name":"Ismael","last_name":"Aldás"},{"first_name":"Olivia Box","last_name":"Power","full_name":"Power, Olivia Box"},{"first_name":"Nicola J.","last_name":"Nadeau","full_name":"Nadeau, Nicola J."},{"full_name":"Bridle, Jon R.","first_name":"Jon R.","last_name":"Bridle"},{"first_name":"Campbell","last_name":"Rolian","full_name":"Rolian, Campbell"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"},{"last_name":"McMillan","first_name":"W. Owen","full_name":"McMillan, W. Owen"},{"full_name":"Jiggins, Chris D.","first_name":"Chris D.","last_name":"Jiggins"},{"last_name":"Chan","first_name":"Yingguang Frank","full_name":"Chan, Yingguang Frank"}],"isi":1,"article_processing_charge":"No","citation":{"short":"J.I. Meier, P.A. Salazar, M. Kučka, R.W. Davies, A. Dréau, I. Aldás, O.B. Power, N.J. Nadeau, J.R. Bridle, C. Rolian, N.H. Barton, W.O. McMillan, C.D. Jiggins, Y.F. Chan, Proceedings of the National Academy of Sciences of the United States of America 118 (2021).","chicago":"Meier, Joana I., Patricio A. Salazar, Marek Kučka, Robert William Davies, Andreea Dréau, Ismael Aldás, Olivia Box Power, et al. “Haplotype Tagging Reveals Parallel Formation of Hybrid Races in Two Butterfly Species.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.2015005118\">https://doi.org/10.1073/pnas.2015005118</a>.","ista":"Meier JI, Salazar PA, Kučka M, Davies RW, Dréau A, Aldás I, Power OB, Nadeau NJ, Bridle JR, Rolian C, Barton NH, McMillan WO, Jiggins CD, Chan YF. 2021. Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. Proceedings of the National Academy of Sciences of the United States of America. 118(25), e2015005118.","apa":"Meier, J. I., Salazar, P. A., Kučka, M., Davies, R. W., Dréau, A., Aldás, I., … Chan, Y. F. (2021). Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2015005118\">https://doi.org/10.1073/pnas.2015005118</a>","ama":"Meier JI, Salazar PA, Kučka M, et al. Haplotype tagging reveals parallel formation of hybrid races in two butterfly species. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2021;118(25). doi:<a href=\"https://doi.org/10.1073/pnas.2015005118\">10.1073/pnas.2015005118</a>","ieee":"J. I. Meier <i>et al.</i>, “Haplotype tagging reveals parallel formation of hybrid races in two butterfly species,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 25. National Academy of Sciences, 2021.","mla":"Meier, Joana I., et al. “Haplotype Tagging Reveals Parallel Formation of Hybrid Races in Two Butterfly Species.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 118, no. 25, e2015005118, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.2015005118\">10.1073/pnas.2015005118</a>."},"oa":1,"acknowledgement":"We thank Felicity Jones for input into experimental design, helpful discussion and improving the manuscript. We thank the Rolian, Jiggins, Chan and Jones Labs members for support, insightful scientific discussion and improving the manuscript. We thank the Rolian lab members, the Animal Resource Centre staff at the University of Calgary, and Caroline Schmid and Ann-Katrin Geysel at the Friedrich Miescher Laboratory for animal husbandry. We thank Christa Lanz, Rebecca Schwab and Ilja Bezrukov for assistance with high-throughput sequencing and associated data processing; Andre Noll and the MPI Tübingen IT team for computational support. We thank Ben Haller and Richard Durbin for helpful discussions. We thank David M. Kingsley for thoughtful input that has greatly improved our manuscript. J.I.M. is supported by a Research Fellowship from St. John’s College, Cambridge. A.D. was supported by a European Research Council Consolidator Grant (No. 617279 “EvolRecombAdapt”, P/I Felicity Jones). C.R. is supported by Discovery Grant #4181932 from the Natural Sciences and Engineering Research Council of Canada and by the Faculty of Veterinary Medicine at the University of Calgary. C.D.J. is supported by a BBSRC grant BB/R007500 and a European Research Council Advanced Grant (No. 339873 “SpeciationGenetics”). M.K. and Y.F.C. are supported by the Max Planck Society and a European Research Council Starting Grant (No. 639096 “HybridMiX”).","external_id":{"isi":["000671755600001"],"pmid":["34155138"]},"date_updated":"2025-05-14T10:58:04Z","department":[{"_id":"NiBa"}],"oa_version":"Published Version","file_date_updated":"2022-03-08T08:18:16Z","_id":"9375","article_number":"e2015005118","file":[{"creator":"dernst","file_size":20592929,"file_name":"2021_PNAS_Meier.pdf","file_id":"10835","checksum":"cb30c6166b2132ee60d616b31a1a7c29","access_level":"open_access","date_updated":"2022-03-08T08:18:16Z","date_created":"2022-03-08T08:18:16Z","content_type":"application/pdf","success":1,"relation":"main_file"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"doi":"10.1073/pnas.2015005118","publisher":"National Academy of Sciences","article_type":"original","type":"journal_article","pmid":1,"issue":"25","ddc":["570"],"year":"2021","date_published":"2021-06-21T00:00:00Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-07T17:10:21Z"},{"keyword":["multistability","mechanism","computational design","rigidity"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2021-05-08T17:37:08Z","status":"public","date_published":"2021-10-08T00:00:00Z","year":"2021","ddc":["000"],"acknowledged_ssus":[{"_id":"M-Shop"}],"issue":"5","article_type":"original","type":"journal_article","publisher":"Association for Computing Machinery","doi":"10.1145/3453477","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"9376","article_number":"186","file":[{"file_name":"Multistable-authorversion.pdf","file_size":18926557,"file_id":"9377","creator":"bbickel","access_level":"open_access","date_updated":"2021-05-08T17:36:59Z","checksum":"8564b3118457d4c8939a8ef2b1a2f16c","date_created":"2021-05-08T17:36:59Z","content_type":"application/pdf","relation":"main_file"},{"file_id":"9378","file_name":"multistable-video.mp4","file_size":76542901,"creator":"bbickel","date_updated":"2021-05-08T17:38:22Z","access_level":"open_access","checksum":"3b6e874e30bfa1bfc3ad3498710145a1","content_type":"video/mp4","success":1,"date_created":"2021-05-08T17:38:22Z","relation":"main_file"},{"checksum":"20dc3bc42e1a912a5b0247c116772098","access_level":"open_access","description":"This document provides additional results and analyzes the robustness and limitations of our approach.","date_updated":"2021-12-17T08:13:51Z","creator":"bbickel","file_size":3367072,"file_name":"multistable-supplementary material.pdf","file_id":"10562","relation":"supplementary_material","title":"Supplementary Material for “Computational Design of Planar Multistable Compliant Structures”","date_created":"2021-12-17T08:13:51Z","content_type":"application/pdf"}],"file_date_updated":"2021-12-17T08:13:51Z","oa_version":"Published Version","department":[{"_id":"BeBi"}],"date_updated":"2025-03-31T15:58:16Z","external_id":{"isi":["000752079300003"]},"acknowledgement":"We would like to thank everyone who contributed to this paper, the authors of artworks for all the examples, including @macrovec-tor_official and Wikimedia for the FLAG semaphore, and @pikisuper-star for the FIGURINE. The photos of iconic poses in the teaser were supplied by (from left to right): Mike Hewitt/Olympics Day 8 - Athletics/Gettty Images, Oneinchpunch/Basketball player training on acourt in New york city/Shutterstock, and Andrew Redington/TigerWoods/Getty Images. We also want to express our gratitude to Christian Hafner for insightful discussions, the IST Austria machine shop SSU, all proof-readers, and anonymous reviewers. This project has received funding from the European Union’s Horizon 2020 research and innovation programme, under the Marie Skłodowska-Curie grant agreement No 642841 (DISTRO), and under the European Research Council grant agreement No 715767 (MATERIALIZABLE).","oa":1,"citation":{"mla":"Zhang, Ran, et al. “Computational Design of Planar Multistable Compliant Structures.” <i>ACM Transactions on Graphics</i>, vol. 40, no. 5, 186, Association for Computing Machinery, 2021, doi:<a href=\"https://doi.org/10.1145/3453477\">10.1145/3453477</a>.","ieee":"R. Zhang, T. Auzinger, and B. Bickel, “Computational design of planar multistable compliant structures,” <i>ACM Transactions on Graphics</i>, vol. 40, no. 5. Association for Computing Machinery, 2021.","short":"R. Zhang, T. Auzinger, B. Bickel, ACM Transactions on Graphics 40 (2021).","chicago":"Zhang, Ran, Thomas Auzinger, and Bernd Bickel. “Computational Design of Planar Multistable Compliant Structures.” <i>ACM Transactions on Graphics</i>. Association for Computing Machinery, 2021. <a href=\"https://doi.org/10.1145/3453477\">https://doi.org/10.1145/3453477</a>.","ista":"Zhang R, Auzinger T, Bickel B. 2021. Computational design of planar multistable compliant structures. ACM Transactions on Graphics. 40(5), 186.","ama":"Zhang R, Auzinger T, Bickel B. Computational design of planar multistable compliant structures. <i>ACM Transactions on Graphics</i>. 2021;40(5). doi:<a href=\"https://doi.org/10.1145/3453477\">10.1145/3453477</a>","apa":"Zhang, R., Auzinger, T., &#38; Bickel, B. (2021). Computational design of planar multistable compliant structures. <i>ACM Transactions on Graphics</i>. Association for Computing Machinery. <a href=\"https://doi.org/10.1145/3453477\">https://doi.org/10.1145/3453477</a>"},"article_processing_charge":"No","isi":1,"author":[{"first_name":"Ran","id":"4DDBCEB0-F248-11E8-B48F-1D18A9856A87","last_name":"Zhang","full_name":"Zhang, Ran","orcid":"0000-0002-3808-281X"},{"full_name":"Auzinger, Thomas","orcid":"0000-0002-1546-3265","first_name":"Thomas","id":"4718F954-F248-11E8-B48F-1D18A9856A87","last_name":"Auzinger"},{"orcid":"0000-0001-6511-9385","full_name":"Bickel, Bernd","last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"642841","call_identifier":"H2020","name":"Distributed 3D Object Design","_id":"2508E324-B435-11E9-9278-68D0E5697425"},{"grant_number":"715767","_id":"24F9549A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"volume":40,"scopus_import":"1","month":"10","publication_identifier":{"issn":["0730-0301"],"eissn":["1557-7368"]},"ec_funded":1,"has_accepted_license":"1","publication_status":"published","title":"Computational design of planar multistable compliant structures","publication":"ACM Transactions on Graphics","abstract":[{"text":"This paper presents a method for designing planar multistable compliant structures. Given a sequence of desired stable states and the corresponding poses of the structure, we identify the topology and geometric realization of a mechanism—consisting of bars and joints—that is able to physically reproduce the desired multistable behavior. In order to solve this problem efficiently, we build on insights from minimally rigid graph theory to identify simple but effective topologies for the mechanism. We then optimize its geometric parameters, such as joint positions and bar lengths, to obtain correct transitions between the given poses. Simultaneously, we ensure adequate stability of each pose based on an effective approximate error metric related to the elastic energy Hessian of the bars in the mechanism. As demonstrated by our results, we obtain functional multistable mechanisms of manageable complexity that can be fabricated using 3D printing. Further, we evaluated the effectiveness of our method on a large number of examples in the simulation and fabricated several physical prototypes.","lang":"eng"}],"intvolume":"        40","quality_controlled":"1","day":"08"},{"doi":"10.3389/fcell.2021.649433","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"9379","article_number":"649433","file":[{"checksum":"8c8a03575d2f7583f88dc3b658b0976b","date_updated":"2021-05-11T15:09:23Z","access_level":"open_access","creator":"kschuh","file_id":"9386","file_size":4076024,"file_name":"2021_Frontiers_Cell_Bolger-Munro.pdf","relation":"main_file","success":1,"content_type":"application/pdf","date_created":"2021-05-11T15:09:23Z"}],"oa_version":"Published Version","file_date_updated":"2021-05-11T15:09:23Z","department":[{"_id":"CaHe"}],"date_updated":"2023-10-18T08:19:49Z","external_id":{"isi":["000644419500001"],"pmid":["33928084"]},"keyword":["B cell","actin","immune synapse","cell spreading","cofilin","WDR1 (AIP1)","LIM domain kinase","B cell receptor (BCR)"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-09T22:01:37Z","date_published":"2021-04-13T00:00:00Z","status":"public","year":"2021","pmid":1,"ddc":["570"],"publisher":"Frontiers Media","type":"journal_article","article_type":"original","publication_status":"published","title":"The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse","has_accepted_license":"1","abstract":[{"lang":"eng","text":"When B cells encounter membrane-bound antigens, the formation and coalescence of B cell antigen receptor (BCR) microclusters amplifies BCR signaling. The ability of B cells to probe the surface of antigen-presenting cells (APCs) and respond to APC-bound antigens requires remodeling of the actin cytoskeleton. Initial BCR signaling stimulates actin-related protein (Arp) 2/3 complex-dependent actin polymerization, which drives B cell spreading as well as the centripetal movement and coalescence of BCR microclusters at the B cell-APC synapse. Sustained actin polymerization depends on concomitant actin filament depolymerization, which enables the recycling of actin monomers and Arp2/3 complexes. Cofilin-mediated severing of actin filaments is a rate-limiting step in the morphological changes that occur during immune synapse formation. Hence, regulators of cofilin activity such as WD repeat-containing protein 1 (Wdr1), LIM domain kinase (LIMK), and coactosin-like 1 (Cotl1) may also be essential for actin-dependent processes in B cells. Wdr1 enhances cofilin-mediated actin disassembly. Conversely, Cotl1 competes with cofilin for binding to actin and LIMK phosphorylates cofilin and prevents it from binding to actin filaments. We now show that Wdr1 and LIMK have distinct roles in BCR-induced assembly of the peripheral actin structures that drive B cell spreading, and that cofilin, Wdr1, and LIMK all contribute to the actin-dependent amplification of BCR signaling at the immune synapse. Depleting Cotl1 had no effect on these processes. Thus, the Wdr1-LIMK-cofilin axis is critical for BCR-induced actin remodeling and for B cell responses to APC-bound antigens."}],"intvolume":"         9","publication":"Frontiers in Cell and Developmental Biology","quality_controlled":"1","day":"13","acknowledgement":"We thank the UBC Life Sciences Institute Imaging Facility andthe UBC Flow Cytometry Facility.","oa":1,"article_processing_charge":"No","isi":1,"citation":{"short":"M. Bolger-Munro, K. Choi, F. Cheung, Y.T. Liu, M. Dang-Lawson, N. Deretic, C. Keane, M.R. Gold, Frontiers in Cell and Developmental Biology 9 (2021).","ama":"Bolger-Munro M, Choi K, Cheung F, et al. The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse. <i>Frontiers in Cell and Developmental Biology</i>. 2021;9. doi:<a href=\"https://doi.org/10.3389/fcell.2021.649433\">10.3389/fcell.2021.649433</a>","apa":"Bolger-Munro, M., Choi, K., Cheung, F., Liu, Y. T., Dang-Lawson, M., Deretic, N., … Gold, M. R. (2021). The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse. <i>Frontiers in Cell and Developmental Biology</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/fcell.2021.649433\">https://doi.org/10.3389/fcell.2021.649433</a>","chicago":"Bolger-Munro, Madison, Kate Choi, Faith Cheung, Yi Tian Liu, May Dang-Lawson, Nikola Deretic, Connor Keane, and Michael R. Gold. “The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse.” <i>Frontiers in Cell and Developmental Biology</i>. Frontiers Media, 2021. <a href=\"https://doi.org/10.3389/fcell.2021.649433\">https://doi.org/10.3389/fcell.2021.649433</a>.","ista":"Bolger-Munro M, Choi K, Cheung F, Liu YT, Dang-Lawson M, Deretic N, Keane C, Gold MR. 2021. The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse. Frontiers in Cell and Developmental Biology. 9, 649433.","mla":"Bolger-Munro, Madison, et al. “The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse.” <i>Frontiers in Cell and Developmental Biology</i>, vol. 9, 649433, Frontiers Media, 2021, doi:<a href=\"https://doi.org/10.3389/fcell.2021.649433\">10.3389/fcell.2021.649433</a>.","ieee":"M. Bolger-Munro <i>et al.</i>, “The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse,” <i>Frontiers in Cell and Developmental Biology</i>, vol. 9. Frontiers Media, 2021."},"language":[{"iso":"eng"}],"author":[{"last_name":"Bolger-Munro","first_name":"Madison","id":"516F03FA-93A3-11EA-A7C5-D6BE3DDC885E","orcid":"0000-0002-8176-4824","full_name":"Bolger-Munro, Madison"},{"full_name":"Choi, Kate","last_name":"Choi","first_name":"Kate"},{"first_name":"Faith","last_name":"Cheung","full_name":"Cheung, Faith"},{"last_name":"Liu","first_name":"Yi Tian","full_name":"Liu, Yi Tian"},{"full_name":"Dang-Lawson, May","last_name":"Dang-Lawson","first_name":"May"},{"full_name":"Deretic, Nikola","last_name":"Deretic","first_name":"Nikola"},{"full_name":"Keane, Connor","first_name":"Connor","last_name":"Keane"},{"last_name":"Gold","first_name":"Michael R.","full_name":"Gold, Michael R."}],"month":"04","scopus_import":"1","volume":9,"publication_identifier":{"eissn":["2296-634X"]}},{"article_processing_charge":"No","citation":{"mla":"Seferbekova, Zaira, et al. “High Rates of Genome Rearrangements and Pathogenicity of Shigella Spp.” <i>Frontiers in Microbiology</i>, vol. 12, 628622, Frontiers, 2021, doi:<a href=\"https://doi.org/10.3389/fmicb.2021.628622\">10.3389/fmicb.2021.628622</a>.","ieee":"Z. Seferbekova <i>et al.</i>, “High rates of genome rearrangements and pathogenicity of Shigella spp,” <i>Frontiers in Microbiology</i>, vol. 12. Frontiers, 2021.","short":"Z. Seferbekova, A. Zabelkin, Y. Yakovleva, R. Afasizhev, N.O. Dranenko, N. Alexeev, M.S. Gelfand, O. Bochkareva, Frontiers in Microbiology 12 (2021).","ama":"Seferbekova Z, Zabelkin A, Yakovleva Y, et al. High rates of genome rearrangements and pathogenicity of Shigella spp. <i>Frontiers in Microbiology</i>. 2021;12. doi:<a href=\"https://doi.org/10.3389/fmicb.2021.628622\">10.3389/fmicb.2021.628622</a>","apa":"Seferbekova, Z., Zabelkin, A., Yakovleva, Y., Afasizhev, R., Dranenko, N. O., Alexeev, N., … Bochkareva, O. (2021). High rates of genome rearrangements and pathogenicity of Shigella spp. <i>Frontiers in Microbiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmicb.2021.628622\">https://doi.org/10.3389/fmicb.2021.628622</a>","ista":"Seferbekova Z, Zabelkin A, Yakovleva Y, Afasizhev R, Dranenko NO, Alexeev N, Gelfand MS, Bochkareva O. 2021. High rates of genome rearrangements and pathogenicity of Shigella spp. Frontiers in Microbiology. 12, 628622.","chicago":"Seferbekova, Zaira, Alexey Zabelkin, Yulia Yakovleva, Robert Afasizhev, Natalia O. Dranenko, Nikita Alexeev, Mikhail S. Gelfand, and Olga Bochkareva. “High Rates of Genome Rearrangements and Pathogenicity of Shigella Spp.” <i>Frontiers in Microbiology</i>. Frontiers, 2021. <a href=\"https://doi.org/10.3389/fmicb.2021.628622\">https://doi.org/10.3389/fmicb.2021.628622</a>."},"isi":1,"language":[{"iso":"eng"}],"project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"author":[{"full_name":"Seferbekova, Zaira","first_name":"Zaira","last_name":"Seferbekova"},{"last_name":"Zabelkin","first_name":"Alexey","full_name":"Zabelkin, Alexey"},{"first_name":"Yulia","last_name":"Yakovleva","full_name":"Yakovleva, Yulia"},{"last_name":"Afasizhev","first_name":"Robert","full_name":"Afasizhev, Robert"},{"full_name":"Dranenko, Natalia O.","last_name":"Dranenko","first_name":"Natalia O."},{"full_name":"Alexeev, Nikita","first_name":"Nikita","last_name":"Alexeev"},{"first_name":"Mikhail S.","last_name":"Gelfand","full_name":"Gelfand, Mikhail S."},{"orcid":"0000-0003-1006-6639","full_name":"Bochkareva, Olga","last_name":"Bochkareva","id":"C4558D3C-6102-11E9-A62E-F418E6697425","first_name":"Olga"}],"acknowledgement":"We thank Fyodor Kondrashov for valuable advice and manuscript proofreading. We also thank Alla Mikheenko for assistance with Circos.","oa":1,"publication_identifier":{"eissn":["1664-302X"]},"month":"04","scopus_import":"1","volume":12,"corr_author":"1","title":"High rates of genome rearrangements and pathogenicity of Shigella spp","publication_status":"published","has_accepted_license":"1","intvolume":"        12","abstract":[{"lang":"eng","text":"Shigella are pathogens originating within the Escherichia lineage but frequently classified as a separate genus. Shigella genomes contain numerous insertion sequences (ISs) that lead to pseudogenisation of affected genes and an increase of non-homologous recombination. Here, we study 414 genomes of E. coli and Shigella strains to assess the contribution of genomic rearrangements to Shigella evolution. We found that Shigella experienced exceptionally high rates of intragenomic rearrangements and had a decreased rate of homologous recombination compared to pathogenic and non-pathogenic E. coli. The high rearrangement rate resulted in independent disruption of syntenic regions and parallel rearrangements in different Shigella lineages. Specifically, we identified two types of chromosomally encoded E3 ubiquitin-protein ligases acquired independently by all Shigella strains that also showed a high level of sequence conservation in the promoter and further in the 5′-intergenic region. In the only available enteroinvasive E. coli (EIEC) strain, which is a pathogenic E. coli with a phenotype intermediate between Shigella and non-pathogenic E. coli, we found a rate of genome rearrangements comparable to those in other E. coli and no functional copies of the two Shigella-specific E3 ubiquitin ligases. These data indicate that the accumulation of ISs influenced many aspects of genome evolution and played an important role in the evolution of intracellular pathogens. Our research demonstrates the power of comparative genomics-based on synteny block composition and an important role of non-coding regions in the evolution of genomic islands."}],"publication":"Frontiers in Microbiology","ec_funded":1,"quality_controlled":"1","day":"12","date_published":"2021-04-12T00:00:00Z","status":"public","date_created":"2021-05-09T22:01:38Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Frontiers","type":"journal_article","article_type":"original","year":"2021","ddc":["570"],"_id":"9380","article_number":"628622","file":[{"relation":"main_file","date_created":"2021-05-11T13:05:52Z","success":1,"content_type":"application/pdf","access_level":"open_access","date_updated":"2021-05-11T13:05:52Z","checksum":"2f856543add59273a482a7f326fc0400","file_name":"2021_Frontiers_Microbiology_Seferbekova.pdf","file_size":14362316,"file_id":"9384","creator":"kschuh"}],"oa_version":"Published Version","file_date_updated":"2021-05-11T13:05:52Z","doi":"10.3389/fmicb.2021.628622","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_updated":"2025-04-14T07:43:52Z","external_id":{"isi":["000643713300001"]},"department":[{"_id":"FyKo"}]},{"article_type":"original","type":"journal_article","publisher":"Public Library of Science","ddc":["000"],"pmid":1,"issue":"4","year":"2021","status":"public","date_published":"2021-04-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-09T22:01:38Z","external_id":{"isi":["000639711200001"],"pmid":["33844680"]},"date_updated":"2025-06-12T06:40:39Z","department":[{"_id":"KrCh"}],"file_date_updated":"2021-05-11T13:50:06Z","oa_version":"Published Version","article_number":"e1008523","_id":"9381","file":[{"file_id":"9385","file_name":"2021_pcbi_Kleshnina.pdf","file_size":1323820,"creator":"kschuh","date_updated":"2021-05-11T13:50:06Z","access_level":"open_access","checksum":"a94ebe0c4116f5047eaa6029e54d2dac","success":1,"content_type":"application/pdf","date_created":"2021-05-11T13:50:06Z","relation":"main_file"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1371/journal.pcbi.1008523","publication_identifier":{"eissn":["1553-7358"],"issn":["1553-734X"]},"volume":17,"scopus_import":"1","month":"04","author":[{"full_name":"Kleshnina, Maria","last_name":"Kleshnina","first_name":"Maria","id":"4E21749C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Streipert, Sabrina S.","last_name":"Streipert","first_name":"Sabrina S."},{"full_name":"Filar, Jerzy A.","last_name":"Filar","first_name":"Jerzy A."},{"last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","grant_number":"863818"}],"article_processing_charge":"No","isi":1,"citation":{"ieee":"M. Kleshnina, S. S. Streipert, J. A. Filar, and K. Chatterjee, “Mistakes can stabilise the dynamics of rock-paper-scissors games,” <i>PLoS Computational Biology</i>, vol. 17, no. 4. Public Library of Science, 2021.","mla":"Kleshnina, Maria, et al. “Mistakes Can Stabilise the Dynamics of Rock-Paper-Scissors Games.” <i>PLoS Computational Biology</i>, vol. 17, no. 4, e1008523, Public Library of Science, 2021, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1008523\">10.1371/journal.pcbi.1008523</a>.","ama":"Kleshnina M, Streipert SS, Filar JA, Chatterjee K. Mistakes can stabilise the dynamics of rock-paper-scissors games. <i>PLoS Computational Biology</i>. 2021;17(4). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1008523\">10.1371/journal.pcbi.1008523</a>","apa":"Kleshnina, M., Streipert, S. S., Filar, J. A., &#38; Chatterjee, K. (2021). Mistakes can stabilise the dynamics of rock-paper-scissors games. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1008523\">https://doi.org/10.1371/journal.pcbi.1008523</a>","chicago":"Kleshnina, Maria, Sabrina S. Streipert, Jerzy A. Filar, and Krishnendu Chatterjee. “Mistakes Can Stabilise the Dynamics of Rock-Paper-Scissors Games.” <i>PLoS Computational Biology</i>. Public Library of Science, 2021. <a href=\"https://doi.org/10.1371/journal.pcbi.1008523\">https://doi.org/10.1371/journal.pcbi.1008523</a>.","ista":"Kleshnina M, Streipert SS, Filar JA, Chatterjee K. 2021. Mistakes can stabilise the dynamics of rock-paper-scissors games. PLoS Computational Biology. 17(4), e1008523.","short":"M. Kleshnina, S.S. Streipert, J.A. Filar, K. Chatterjee, PLoS Computational Biology 17 (2021)."},"oa":1,"acknowledgement":"Authors would like to thank Christian Hilbe and Martin Nowak for their inspiring and very helpful feedback on the manuscript.","day":"01","quality_controlled":"1","publication":"PLoS Computational Biology","abstract":[{"lang":"eng","text":"A game of rock-paper-scissors is an interesting example of an interaction where none of the pure strategies strictly dominates all others, leading to a cyclic pattern. In this work, we consider an unstable version of rock-paper-scissors dynamics and allow individuals to make behavioural mistakes during the strategy execution. We show that such an assumption can break a cyclic relationship leading to a stable equilibrium emerging with only one strategy surviving. We consider two cases: completely random mistakes when individuals have no bias towards any strategy and a general form of mistakes. Then, we determine conditions for a strategy to dominate all other strategies. However, given that individuals who adopt a dominating strategy are still prone to behavioural mistakes in the observed behaviour, we may still observe extinct strategies. That is, behavioural mistakes in strategy execution stabilise evolutionary dynamics leading to an evolutionary stable and, potentially, mixed co-existence equilibrium."}],"intvolume":"        17","has_accepted_license":"1","title":"Mistakes can stabilise the dynamics of rock-paper-scissors games","publication_status":"published","ec_funded":1},{"scopus_import":"1","month":"03","volume":75,"publication_identifier":{"issn":["0014-3820"],"eissn":["1558-5646"]},"acknowledgement":"We thank M. Garlovsky, S. Martin, C. Cooney, C. Roux, J. Larson, and J. Mallet for critical feedback and for discussion. K. Lohse, M. de la Cámara, J. Cerca, M. A. Chase, C. Baskett, A. M. Westram, and N. H. Barton gave feedback on a draft of the manuscript. O. Seehausen, two anonymous reviewers, and the AE (Michael Kopp) provided comments that greatly improved the manuscript. V. Holzmann made many corrections to the proofs. G. Bisschop and K. Lohse kindly contributed the simulations and analyses presented in Box 3. We would also like to extend our thanks to everyone who took part in the speciation survey, which received ethical approval through the University of Sheffield Ethics Review Procedure (Application 029768). We are especially grateful to R. K. Butlin for stimulating discussion throughout the writing of the manuscript and for feedback on an earlier draft.","oa":1,"citation":{"mla":"Stankowski, Sean, and Mark Ravinet. “Defining the Speciation Continuum.” <i>Evolution</i>, vol. 75, no. 6, Oxford University Press, 2021, pp. 1256–73, doi:<a href=\"https://doi.org/10.1111/evo.14215\">10.1111/evo.14215</a>.","ieee":"S. Stankowski and M. Ravinet, “Defining the speciation continuum,” <i>Evolution</i>, vol. 75, no. 6. Oxford University Press, pp. 1256–1273, 2021.","chicago":"Stankowski, Sean, and Mark Ravinet. “Defining the Speciation Continuum.” <i>Evolution</i>. Oxford University Press, 2021. <a href=\"https://doi.org/10.1111/evo.14215\">https://doi.org/10.1111/evo.14215</a>.","ista":"Stankowski S, Ravinet M. 2021. Defining the speciation continuum. Evolution. 75(6), 1256–1273.","ama":"Stankowski S, Ravinet M. Defining the speciation continuum. <i>Evolution</i>. 2021;75(6):1256-1273. doi:<a href=\"https://doi.org/10.1111/evo.14215\">10.1111/evo.14215</a>","apa":"Stankowski, S., &#38; Ravinet, M. (2021). Defining the speciation continuum. <i>Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1111/evo.14215\">https://doi.org/10.1111/evo.14215</a>","short":"S. Stankowski, M. Ravinet, Evolution 75 (2021) 1256–1273."},"article_processing_charge":"No","isi":1,"page":"1256-1273","language":[{"iso":"eng"}],"author":[{"id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","last_name":"Stankowski","full_name":"Stankowski, Sean"},{"full_name":"Ravinet, Mark","first_name":"Mark","last_name":"Ravinet"}],"quality_controlled":"1","day":"22","publication_status":"published","title":"Defining the speciation continuum","has_accepted_license":"1","intvolume":"        75","abstract":[{"text":"A primary roadblock to our understanding of speciation is that it usually occurs over a timeframe that is too long to study from start to finish. The idea of a speciation continuum provides something of a solution to this problem; rather than observing the entire process, we can simply reconstruct it from the multitude of speciation events that surround us. But what do we really mean when we talk about the speciation continuum, and can it really help us understand speciation? We explored these questions using a literature review and online survey of speciation researchers. Although most researchers were familiar with the concept and thought it was useful, our survey revealed extensive disagreement about what the speciation continuum actually tells us. This is due partly to the lack of a clear definition. Here, we provide an explicit definition that is compatible with the Biological Species Concept. That is, the speciation continuum is a continuum of reproductive isolation. After outlining the logic of the definition in light of alternatives, we explain why attempts to reconstruct the speciation process from present‐day populations will ultimately fail. We then outline how we think the speciation continuum concept can continue to act as a foundation for understanding the continuum of reproductive isolation that surrounds us.","lang":"eng"}],"publication":"Evolution","year":"2021","issue":"6","ddc":["570"],"publisher":"Oxford University Press","type":"journal_article","article_type":"original","date_created":"2021-05-09T22:01:39Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2021-03-22T00:00:00Z","status":"public","department":[{"_id":"NiBa"}],"date_updated":"2023-10-18T08:16:01Z","external_id":{"isi":["000647226400001"]},"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"doi":"10.1111/evo.14215","file":[{"file_id":"10921","file_name":"2021_Evolution_Stankowski.pdf","file_size":719991,"creator":"kschuh","date_updated":"2022-03-25T12:02:04Z","access_level":"open_access","checksum":"96f6ccf15d95a4e9f7c0b27eee570fa6","content_type":"application/pdf","success":1,"date_created":"2022-03-25T12:02:04Z","relation":"main_file"}],"_id":"9383","oa_version":"Published Version","file_date_updated":"2022-03-25T12:02:04Z"},{"acknowledged_ssus":[{"_id":"NanoFab"}],"ddc":["530"],"license":"https://creativecommons.org/publicdomain/zero/1.0/","year":"2021","publisher":"Institute of Science and Technology Austria","type":"research_data","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-14T12:07:53Z","oa":1,"author":[{"full_name":"Valentini, Marco","last_name":"Valentini","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425","first_name":"Marco"}],"date_published":"2021-01-01T00:00:00Z","article_processing_charge":"No","citation":{"ieee":"M. Valentini, “Research data for ‘Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states.’” Institute of Science and Technology Austria, 2021.","mla":"Valentini, Marco. <i>Research Data for “Non-Topological Zero Bias Peaks in Full-Shell Nanowires Induced by Flux Tunable Andreev States.”</i> Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9389\">10.15479/AT:ISTA:9389</a>.","short":"M. Valentini, (2021).","chicago":"Valentini, Marco. “Research Data for ‘Non-Topological Zero Bias Peaks in Full-Shell Nanowires Induced by Flux Tunable Andreev States.’” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9389\">https://doi.org/10.15479/AT:ISTA:9389</a>.","ista":"Valentini M. 2021. Research data for ‘Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9389\">10.15479/AT:ISTA:9389</a>.","apa":"Valentini, M. (2021). Research data for “Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9389\">https://doi.org/10.15479/AT:ISTA:9389</a>","ama":"Valentini M. Research data for “Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states.” 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9389\">10.15479/AT:ISTA:9389</a>"},"contributor":[{"first_name":"Marco","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425","last_name":"Valentini","contributor_type":"contact_person"}],"status":"public","department":[{"_id":"GradSch"},{"_id":"GeKa"}],"related_material":{"record":[{"id":"8910","relation":"used_in_publication","status":"public"}]},"date_updated":"2025-06-12T06:32:43Z","tmp":{"short":"CC0 (1.0)","image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)"},"doi":"10.15479/AT:ISTA:9389","abstract":[{"lang":"eng","text":"This .zip File contains the transport data for  \"Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states\" by M. Valentini, et. al.  \r\nThe measurements were done using Labber Software and the data is stored in the hdf5 file format.\r\nInstructions of how to read the data are in \"Notebook_Valentini.pdf\"."}],"oa_version":"Published Version","file_date_updated":"2021-05-14T11:56:48Z","title":"Research data for \"Non-topological zero bias peaks in full-shell nanowires induced by flux tunable Andreev states\"","_id":"9389","file":[{"access_level":"open_access","date_updated":"2021-05-14T11:42:23Z","checksum":"80a905c4eef24dab6fb247e81a3d67f5","file_size":10572981,"file_name":"Notebook_Valentini.pdf","file_id":"9390","creator":"mvalenti","relation":"main_file","date_created":"2021-05-14T11:42:23Z","content_type":"application/pdf"},{"access_level":"open_access","date_updated":"2021-05-14T11:56:48Z","checksum":"1e61a7e63949448a8db0091cdac23570","file_size":99076111,"file_name":"Experimental_data.zip","file_id":"9391","creator":"mvalenti","relation":"main_file","date_created":"2021-05-14T11:56:48Z","content_type":"application/x-zip-compressed"}],"has_accepted_license":"1"},{"publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"month":"05","scopus_import":"1","volume":31,"isi":1,"article_processing_charge":"No","citation":{"ieee":"S. Stankowski and M. Ravinet, “Quantifying the use of species concepts,” <i>Current Biology</i>, vol. 31, no. 9. Cell Press, pp. R428–R429, 2021.","mla":"Stankowski, Sean, and Mark Ravinet. “Quantifying the Use of Species Concepts.” <i>Current Biology</i>, vol. 31, no. 9, Cell Press, 2021, pp. R428–29, doi:<a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">10.1016/j.cub.2021.03.060</a>.","apa":"Stankowski, S., &#38; Ravinet, M. (2021). Quantifying the use of species concepts. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">https://doi.org/10.1016/j.cub.2021.03.060</a>","ama":"Stankowski S, Ravinet M. Quantifying the use of species concepts. <i>Current Biology</i>. 2021;31(9):R428-R429. doi:<a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">10.1016/j.cub.2021.03.060</a>","ista":"Stankowski S, Ravinet M. 2021. Quantifying the use of species concepts. Current Biology. 31(9), R428–R429.","chicago":"Stankowski, Sean, and Mark Ravinet. “Quantifying the Use of Species Concepts.” <i>Current Biology</i>. Cell Press, 2021. <a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">https://doi.org/10.1016/j.cub.2021.03.060</a>.","short":"S. Stankowski, M. Ravinet, Current Biology 31 (2021) R428–R429."},"page":"R428-R429","language":[{"iso":"eng"}],"author":[{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","last_name":"Stankowski"},{"last_name":"Ravinet","first_name":"Mark","full_name":"Ravinet, Mark"}],"acknowledgement":"We thank Christopher Cooney, Martin Garlovsky, Anja M. Westram, Carina Baskett, Stefanie Belohlavy, Michal Hledik, Arka Pal, Nicholas H. Barton, Roger K. Butlin and members of the University of Sheffield Speciation Journal Club for feedback on draft survey questions and/or comments on a draft manuscript. Three anonymous reviewers gave thoughtful feedback that improved the manuscript. We thank Ahmad Nadeem, who was paid to build the Shiny app. We are especially grateful to everyone who took part in the survey. Ethical approval for the survey was obtained through the University of Sheffield Ethics Review Procedure (Application 029768). S.S. was supported by a NERC grant awarded to Roger K. Butlin.","oa":1,"quality_controlled":"1","day":"10","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2021.03.060","open_access":"1"}],"title":"Quantifying the use of species concepts","corr_author":"1","publication_status":"published","intvolume":"        31","abstract":[{"lang":"eng","text":"Humans conceptualize the diversity of life by classifying individuals into types we call ‘species’1. The species we recognize influence political and financial decisions and guide our understanding of how units of diversity evolve and interact. Although the idea of species may seem intuitive, a debate about the best way to define them has raged even before Darwin2. So much energy has been devoted to the so-called ‘species problem’ that no amount of discourse will ever likely solve it2,3. Dozens of species concepts are currently recognized3, but we lack a concrete understanding of how much researchers actually disagree and the factors that cause them to think differently1,2. To address this, we used a survey to quantify the species problem for the first time. The results indicate that the disagreement is extensive: two randomly chosen respondents will most likely disagree on the nature of species. The probability of disagreement is not predicted by researcher experience or broad study system, but tended to be lower among researchers with similar focus, training and who study the same organism. Should we see this diversity of perspectives as a problem? We argue that we should not."}],"publication":"Current Biology","publisher":"Cell Press","article_type":"original","type":"journal_article","year":"2021","issue":"9","pmid":1,"ddc":["570"],"date_published":"2021-05-10T00:00:00Z","status":"public","date_created":"2021-05-16T22:01:46Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-18T19:49:12Z","external_id":{"isi":["000654741200004"],"pmid":["33974865"]},"department":[{"_id":"NiBa"}],"_id":"9392","oa_version":"Published Version","doi":"10.1016/j.cub.2021.03.060"},{"doi":"10.1007/s10703-021-00373-5","oa_version":"Preprint","_id":"9393","department":[{"_id":"KrCh"}],"external_id":{"isi":["000645490300001"],"arxiv":["1504.07384"]},"date_updated":"2025-04-15T07:23:30Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2021-05-16T22:01:47Z","date_published":"2021-09-01T00:00:00Z","status":"public","year":"2021","publisher":"Springer","article_type":"original","type":"journal_article","ec_funded":1,"abstract":[{"lang":"eng","text":"We consider the core algorithmic problems related to verification of systems with respect to three classical quantitative properties, namely, the mean-payoff, the ratio, and the minimum initial credit for energy property. The algorithmic problem given a graph and a quantitative property asks to compute the optimal value (the infimum value over all traces) from every node of the graph. We consider graphs with bounded treewidth—a class that contains the control flow graphs of most programs. Let n denote the number of nodes of a graph, m the number of edges (for bounded treewidth 𝑚=𝑂(𝑛)) and W the largest absolute value of the weights. Our main theoretical results are as follows. First, for the minimum initial credit problem we show that (1) for general graphs the problem can be solved in 𝑂(𝑛2⋅𝑚) time and the associated decision problem in 𝑂(𝑛⋅𝑚) time, improving the previous known 𝑂(𝑛3⋅𝑚⋅log(𝑛⋅𝑊)) and 𝑂(𝑛2⋅𝑚) bounds, respectively; and (2) for bounded treewidth graphs we present an algorithm that requires 𝑂(𝑛⋅log𝑛) time. Second, for bounded treewidth graphs we present an algorithm that approximates the mean-payoff value within a factor of 1+𝜖 in time 𝑂(𝑛⋅log(𝑛/𝜖)) as compared to the classical exact algorithms on general graphs that require quadratic time. Third, for the ratio property we present an algorithm that for bounded treewidth graphs works in time 𝑂(𝑛⋅log(|𝑎⋅𝑏|))=𝑂(𝑛⋅log(𝑛⋅𝑊)), when the output is 𝑎𝑏, as compared to the previously best known algorithm on general graphs with running time 𝑂(𝑛2⋅log(𝑛⋅𝑊)). We have implemented some of our algorithms and show that they present a significant speedup on standard benchmarks."}],"intvolume":"        57","publication":"Formal Methods in System Design","title":"Faster algorithms for quantitative verification in bounded treewidth graphs","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1504.07384"}],"day":"01","quality_controlled":"1","oa":1,"acknowledgement":"The research was partly supported by Austrian Science Fund (FWF) Grant No P23499- N23, FWF NFN Grant No S11407-N23 (RiSE/SHiNE), ERC Start Grant (279307: Graph Games), and Microsoft faculty fellows award.","arxiv":1,"language":[{"iso":"eng"}],"project":[{"grant_number":"P 23499-N23","call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"grant_number":"S 11407_N23","call_identifier":"FWF","name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425"},{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7","grant_number":"279307"},{"name":"Microsoft Research Faculty Fellowship","_id":"2587B514-B435-11E9-9278-68D0E5697425"}],"author":[{"orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","last_name":"Chatterjee","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Ibsen-Jensen","id":"3B699956-F248-11E8-B48F-1D18A9856A87","first_name":"Rasmus","orcid":"0000-0003-4783-0389","full_name":"Ibsen-Jensen, Rasmus"},{"last_name":"Pavlogiannis","id":"49704004-F248-11E8-B48F-1D18A9856A87","first_name":"Andreas","orcid":"0000-0002-8943-0722","full_name":"Pavlogiannis, Andreas"}],"article_processing_charge":"No","isi":1,"citation":{"short":"K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, Formal Methods in System Design 57 (2021) 401–428.","apa":"Chatterjee, K., Ibsen-Jensen, R., &#38; Pavlogiannis, A. (2021). Faster algorithms for quantitative verification in bounded treewidth graphs. <i>Formal Methods in System Design</i>. Springer. <a href=\"https://doi.org/10.1007/s10703-021-00373-5\">https://doi.org/10.1007/s10703-021-00373-5</a>","ama":"Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Faster algorithms for quantitative verification in bounded treewidth graphs. <i>Formal Methods in System Design</i>. 2021;57:401-428. doi:<a href=\"https://doi.org/10.1007/s10703-021-00373-5\">10.1007/s10703-021-00373-5</a>","chicago":"Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis. “Faster Algorithms for Quantitative Verification in Bounded Treewidth Graphs.” <i>Formal Methods in System Design</i>. Springer, 2021. <a href=\"https://doi.org/10.1007/s10703-021-00373-5\">https://doi.org/10.1007/s10703-021-00373-5</a>.","ista":"Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2021. Faster algorithms for quantitative verification in bounded treewidth graphs. Formal Methods in System Design. 57, 401–428.","ieee":"K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, “Faster algorithms for quantitative verification in bounded treewidth graphs,” <i>Formal Methods in System Design</i>, vol. 57. Springer, pp. 401–428, 2021.","mla":"Chatterjee, Krishnendu, et al. “Faster Algorithms for Quantitative Verification in Bounded Treewidth Graphs.” <i>Formal Methods in System Design</i>, vol. 57, Springer, 2021, pp. 401–28, doi:<a href=\"https://doi.org/10.1007/s10703-021-00373-5\">10.1007/s10703-021-00373-5</a>."},"page":"401-428","month":"09","scopus_import":"1","volume":57,"publication_identifier":{"issn":["0925-9856"],"eissn":["1572-8102"]}},{"quality_controlled":"1","day":"07","has_accepted_license":"1","publication_status":"published","title":"Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis","publication":"Evolution Letters","intvolume":"         5","abstract":[{"text":"Chromosomal inversions have long been recognized for their role in local adaptation. By suppressing recombination in heterozygous individuals, they can maintain coadapted gene complexes and protect them from homogenizing effects of gene flow. However, to fully understand their importance for local adaptation we need to know their influence on phenotypes under divergent selection. For this, the marine snail Littorina saxatilis provides an ideal study system. Divergent ecotypes adapted to wave action and crab predation occur in close proximity on intertidal shores with gene flow between them. Here, we used F2 individuals obtained from crosses between the ecotypes to test for associations between genomic regions and traits distinguishing the Crab‐/Wave‐adapted ecotypes including size, shape, shell thickness, and behavior. We show that most of these traits are influenced by two previously detected inversion regions that are divergent between ecotypes. We thus gain a better understanding of one important underlying mechanism responsible for the rapid and repeated formation of ecotypes: divergent selection acting on inversions. We also found that some inversions contributed to more than one trait suggesting that they may contain several loci involved in adaptation, consistent with the hypothesis that suppression of recombination within inversions facilitates differentiation in the presence of gene flow.","lang":"eng"}],"ec_funded":1,"publication_identifier":{"eissn":["2056-3744"]},"volume":5,"month":"05","scopus_import":"1","page":"196-213","isi":1,"citation":{"ieee":"E. L. Koch <i>et al.</i>, “Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis,” <i>Evolution Letters</i>, vol. 5, no. 3. Wiley, pp. 196–213, 2021.","mla":"Koch, Eva L., et al. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” <i>Evolution Letters</i>, vol. 5, no. 3, Wiley, 2021, pp. 196–213, doi:<a href=\"https://doi.org/10.1002/evl3.227\">10.1002/evl3.227</a>.","short":"E.L. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M. Lemmon, K. Johannesson, R.K. Butlin, Evolution Letters 5 (2021) 196–213.","chicago":"Koch, Eva L., Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria, Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” <i>Evolution Letters</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/evl3.227\">https://doi.org/10.1002/evl3.227</a>.","ista":"Koch EL, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM, Johannesson K, Butlin RK. 2021. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Evolution Letters. 5(3), 196–213.","ama":"Koch EL, Morales HE, Larsson J, et al. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. <i>Evolution Letters</i>. 2021;5(3):196-213. doi:<a href=\"https://doi.org/10.1002/evl3.227\">10.1002/evl3.227</a>","apa":"Koch, E. L., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon, A. R., … Butlin, R. K. (2021). Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. <i>Evolution Letters</i>. Wiley. <a href=\"https://doi.org/10.1002/evl3.227\">https://doi.org/10.1002/evl3.227</a>"},"article_processing_charge":"No","author":[{"full_name":"Koch, Eva L.","first_name":"Eva L.","last_name":"Koch"},{"full_name":"Morales, Hernán E.","first_name":"Hernán E.","last_name":"Morales"},{"first_name":"Jenny","last_name":"Larsson","full_name":"Larsson, Jenny"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","last_name":"Westram","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969"},{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"full_name":"Lemmon, Alan R.","last_name":"Lemmon","first_name":"Alan R."},{"full_name":"Lemmon, E. Moriarty","last_name":"Lemmon","first_name":"E. Moriarty"},{"full_name":"Johannesson, Kerstin","first_name":"Kerstin","last_name":"Johannesson"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"}],"project":[{"_id":"265B41B8-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Theoretical and empirical approaches to understanding Parallel Adaptation","grant_number":"797747"}],"language":[{"iso":"eng"}],"acknowledgement":"We are very grateful to Irena Senčić for technical assistance and to Michelle Kortyna and Sean Holland at the Center for Anchored Phylogenomics for assistance with data collection. RKB was funded by the Natural Environment Research Council and by the European Research Council. KJ was funded by the Swedish Research Councils VR and Formas (Linnaeus Grant: 217‐2008‐1719). JL was funded by a studentship from the Leverhulme Centre for Advanced Biological Modelling. AMW was funded by the European Union's Horizon 2020 research and innovation program under Marie Skłodowska‐Curie Grant agreement no. 797747. RF was funded by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie Grant agreement No. 706376 and by FEDER Funds through the Operational Competitiveness Factors Program—COMPETE and by National Funds through FCT—Foundation for Science and Technology within the scope of the project “Hybrabbid” (PTDC/BIA‐EVL/30628/2017‐ POCI‐01‐0145‐FEDER‐030628). We are grateful to other members of the Littorina research group for helpful discussions. We thank Claire Mérot and an anonymous referee for insightful comments on an earlier version. ","oa":1,"date_updated":"2026-04-07T14:01:29Z","related_material":{"record":[{"status":"public","id":"12987","relation":"research_data"}]},"external_id":{"isi":["000647846200001"]},"department":[{"_id":"NiBa"}],"_id":"9394","file":[{"access_level":"open_access","date_updated":"2021-10-15T08:26:02Z","checksum":"023b1608e311f0fda30593ba3d0a4e0b","file_name":"2021_EvolutionLetters_Koch.pdf","file_size":3021108,"file_id":"10142","creator":"cchlebak","relation":"main_file","date_created":"2021-10-15T08:26:02Z","content_type":"application/pdf","success":1}],"file_date_updated":"2021-10-15T08:26:02Z","oa_version":"Published Version","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1002/evl3.227","type":"journal_article","article_type":"original","publisher":"Wiley","year":"2021","ddc":["570"],"issue":"3","status":"public","date_published":"2021-05-07T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2021-05-16T22:01:47Z"},{"publisher":"MIT Press","publication_identifier":{"isbn":["978-0-262-04559-9"]},"type":"book_chapter","series_title":"Strüngmann Forum Reports","month":"03","year":"2021","volume":29,"ddc":["000"],"date_published":"2021-03-01T00:00:00Z","article_processing_charge":"No","citation":{"ieee":"L. Schmid and C. Hilbe, “The evolution of strategic ignorance in strategic interaction,” in <i>Deliberate Ignorance: Choosing Not To Know</i>, vol. 29, R. Hertwig and C. Engel, Eds. MIT Press, 2021, pp. 139–152.","mla":"Schmid, Laura, and Christian Hilbe. “The Evolution of Strategic Ignorance in Strategic Interaction.” <i>Deliberate Ignorance: Choosing Not To Know</i>, edited by Ralph Hertwig and Christoph Engel, vol. 29, MIT Press, 2021, pp. 139–52.","ama":"Schmid L, Hilbe C. The evolution of strategic ignorance in strategic interaction. In: Hertwig R, Engel C, eds. <i>Deliberate Ignorance: Choosing Not To Know</i>. Vol 29. Strüngmann Forum Reports. MIT Press; 2021:139-152.","apa":"Schmid, L., &#38; Hilbe, C. (2021). The evolution of strategic ignorance in strategic interaction. In R. Hertwig &#38; C. Engel (Eds.), <i>Deliberate Ignorance: Choosing Not To Know</i> (Vol. 29, pp. 139–152). MIT Press.","chicago":"Schmid, Laura, and Christian Hilbe. “The Evolution of Strategic Ignorance in Strategic Interaction.” In <i>Deliberate Ignorance: Choosing Not To Know</i>, edited by Ralph Hertwig and Christoph Engel, 29:139–52. Strüngmann Forum Reports. MIT Press, 2021.","ista":"Schmid L, Hilbe C. 2021.The evolution of strategic ignorance in strategic interaction. In: Deliberate Ignorance: Choosing Not To Know. vol. 29, 139–152.","short":"L. Schmid, C. Hilbe, in:, R. Hertwig, C. Engel (Eds.), Deliberate Ignorance: Choosing Not To Know, MIT Press, 2021, pp. 139–152."},"status":"public","page":"139-152","editor":[{"first_name":"Ralph","last_name":"Hertwig","full_name":"Hertwig, Ralph"},{"full_name":"Engel, Christoph","first_name":"Christoph","last_name":"Engel"}],"language":[{"iso":"eng"}],"author":[{"first_name":"Laura","id":"38B437DE-F248-11E8-B48F-1D18A9856A87","last_name":"Schmid","full_name":"Schmid, Laura","orcid":"0000-0002-6978-7329"},{"first_name":"Christian","last_name":"Hilbe","full_name":"Hilbe, Christian"}],"date_created":"2021-05-19T12:25:42Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"quality_controlled":"1","date_updated":"2026-06-18T19:49:35Z","day":"01","main_file_link":[{"open_access":"1","url":"https://esforum.de/publications/PDFs/sfr29/SFR29_09_Hilbe%20and%20Schmid.pdf"}],"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"title":"The evolution of strategic ignorance in strategic interaction","_id":"9403","oa_version":"Published Version","intvolume":"        29","abstract":[{"text":"Optimal decision making requires individuals to know their available options and to anticipate correctly what consequences these options have. In many social interactions, however, we refrain from gathering all relevant information, even if this information would help us make better decisions and is costless to obtain. This chapter examines several examples of “deliberate ignorance.” Two simple models are proposed to illustrate how ignorance can evolve among self-interested and payoff - maximizing individuals, and open problems are highlighted that lie ahead for future research to explore.","lang":"eng"}],"publication":"Deliberate Ignorance: Choosing Not To Know"},{"day":"10","quality_controlled":"1","intvolume":"        12","abstract":[{"lang":"eng","text":"High impact epidemics constitute one of the largest threats humanity is facing in the 21st century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios."}],"publication":"Nature Communications","publication_status":"published","title":"Discontinuous epidemic transition due to limited testing","has_accepted_license":"1","publication_identifier":{"eissn":["2041-1723"]},"month":"05","scopus_import":"1","volume":12,"language":[{"iso":"eng"}],"author":[{"full_name":"Scarselli, Davide","orcid":"0000-0001-5227-4271","first_name":"Davide","id":"40315C30-F248-11E8-B48F-1D18A9856A87","last_name":"Scarselli"},{"id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","first_name":"Nazmi B","last_name":"Budanur","full_name":"Budanur, Nazmi B","orcid":"0000-0003-0423-5010"},{"first_name":"Marc","last_name":"Timme","full_name":"Timme, Marc"},{"first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754"}],"article_processing_charge":"No","citation":{"ieee":"D. Scarselli, N. B. Budanur, M. Timme, and B. Hof, “Discontinuous epidemic transition due to limited testing,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","mla":"Scarselli, Davide, et al. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>, vol. 12, no. 1, 2586, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>.","short":"D. Scarselli, N.B. Budanur, M. Timme, B. Hof, Nature Communications 12 (2021).","apa":"Scarselli, D., Budanur, N. B., Timme, M., &#38; Hof, B. (2021). Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>","ama":"Scarselli D, Budanur NB, Timme M, Hof B. Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>","ista":"Scarselli D, Budanur NB, Timme M, Hof B. 2021. Discontinuous epidemic transition due to limited testing. Nature Communications. 12(1), 2586.","chicago":"Scarselli, Davide, Nazmi B Budanur, Marc Timme, and Björn Hof. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>."},"isi":1,"oa":1,"acknowledgement":"The authors thank Malte Schröder for valuable discussions and creating the scale-free network topologies. B.H. thanks Mukund Vasudevan for helpful discussion. The research by M.T. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy–EXC-2068–390729961–Cluster of Excellence Physics of Life of TU Dresden.","external_id":{"isi":["000687305500044"],"pmid":["33972522"]},"related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/smashing-the-covid-curve/"}]},"date_updated":"2026-04-03T09:37:18Z","department":[{"_id":"BjHo"}],"oa_version":"Published Version","file_date_updated":"2021-05-25T14:18:40Z","file":[{"content_type":"application/pdf","success":1,"date_created":"2021-05-25T14:18:40Z","relation":"main_file","creator":"kschuh","file_id":"9426","file_size":1176573,"file_name":"2021_NatureCommunications_Scarselli.pdf","checksum":"fe26c1b8a7da1ae07a6c03f80ff06ea1","date_updated":"2021-05-25T14:18:40Z","access_level":"open_access"}],"_id":"9407","article_number":"2586","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s41467-021-22725-9","publisher":"Springer Nature","type":"journal_article","article_type":"original","issue":"1","pmid":1,"ddc":["570"],"year":"2021","date_published":"2021-05-10T00:00:00Z","status":"public","date_created":"2021-05-23T22:01:42Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd"},{"volume":27,"scopus_import":"1","month":"06","publication_identifier":{"issn":["1941-0506"],"eissn":["1077-2626"]},"oa":1,"acknowledgement":"The authors would like to thank anonymous reviewers for their constructive comments. Weiwei Xu is partially supported by Zhejiang Lab. Yin Yang is partially spported by NSF under Grant Nos. CHS 1845024 and 1717972. Weiwei Xu and Hujun Bao are supported by Fundamental Research Funds for the Central Universities. This project has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (Grant agreement No 715767).","author":[{"full_name":"Feng, Xudong","first_name":"Xudong","last_name":"Feng"},{"full_name":"Liu, Jiafeng","last_name":"Liu","first_name":"Jiafeng"},{"first_name":"Huamin","last_name":"Wang","full_name":"Wang, Huamin"},{"full_name":"Yang, Yin","first_name":"Yin","last_name":"Yang"},{"last_name":"Bao","first_name":"Hujun","full_name":"Bao, Hujun"},{"last_name":"Bickel","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd","orcid":"0000-0001-6511-9385","full_name":"Bickel, Bernd"},{"full_name":"Xu, Weiwei","first_name":"Weiwei","last_name":"Xu"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"715767","_id":"24F9549A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"citation":{"ieee":"X. Feng <i>et al.</i>, “Computational design of skinned Quad-Robots,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 27, no. 6. IEEE, 2021.","mla":"Feng, Xudong, et al. “Computational Design of Skinned Quad-Robots.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 27, no. 6, 2881–2895, IEEE, 2021, doi:<a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">10.1109/TVCG.2019.2957218</a>.","short":"X. Feng, J. Liu, H. Wang, Y. Yang, H. Bao, B. Bickel, W. Xu, IEEE Transactions on Visualization and Computer Graphics 27 (2021).","ista":"Feng X, Liu J, Wang H, Yang Y, Bao H, Bickel B, Xu W. 2021. Computational design of skinned Quad-Robots. IEEE Transactions on Visualization and Computer Graphics. 27(6), 2881–2895.","chicago":"Feng, Xudong, Jiafeng Liu, Huamin Wang, Yin Yang, Hujun Bao, Bernd Bickel, and Weiwei Xu. “Computational Design of Skinned Quad-Robots.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2021. <a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">https://doi.org/10.1109/TVCG.2019.2957218</a>.","ama":"Feng X, Liu J, Wang H, et al. Computational design of skinned Quad-Robots. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2021;27(6). doi:<a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">10.1109/TVCG.2019.2957218</a>","apa":"Feng, X., Liu, J., Wang, H., Yang, Y., Bao, H., Bickel, B., &#38; Xu, W. (2021). Computational design of skinned Quad-Robots. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">https://doi.org/10.1109/TVCG.2019.2957218</a>"},"isi":1,"article_processing_charge":"No","day":"01","quality_controlled":"1","ec_funded":1,"publication":"IEEE Transactions on Visualization and Computer Graphics","abstract":[{"lang":"eng","text":"We present a computational design system that assists users to model, optimize, and fabricate quad-robots with soft skins. Our system addresses the challenging task of predicting their physical behavior by fully integrating the multibody dynamics of the mechanical skeleton and the elastic behavior of the soft skin. The developed motion control strategy uses an alternating optimization scheme to avoid expensive full space time-optimization, interleaving space-time optimization for the skeleton, and frame-by-frame optimization for the full dynamics. The output are motor torques to drive the robot to achieve a user prescribed motion trajectory. We also provide a collection of convenient engineering tools and empirical manufacturing guidance to support the fabrication of the designed quad-robot. We validate the feasibility of designs generated with our system through physics simulations and with a physically-fabricated prototype."}],"intvolume":"        27","has_accepted_license":"1","title":"Computational design of skinned Quad-Robots","publication_status":"published","ddc":["000"],"pmid":1,"issue":"6","year":"2021","type":"journal_article","publisher":"IEEE","date_created":"2021-05-23T22:01:42Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2021-06-01T00:00:00Z","department":[{"_id":"BeBi"}],"external_id":{"pmid":["31804937"],"isi":["000649620700009"]},"date_updated":"2025-07-10T12:01:44Z","doi":"10.1109/TVCG.2019.2957218","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"file_date_updated":"2021-05-25T15:08:49Z","oa_version":"Published Version","article_number":"2881-2895","_id":"9408","file":[{"file_id":"9427","file_size":6183002,"file_name":"2021_TVCG_Feng.pdf","creator":"kschuh","date_updated":"2021-05-25T15:08:49Z","access_level":"open_access","checksum":"a78e6ac94e33ade4ffaea66943d5f7dc","success":1,"content_type":"application/pdf","date_created":"2021-05-25T15:08:49Z","relation":"main_file"}]},{"scopus_import":"1","month":"05","volume":17,"publication_identifier":{"eissn":["1744-957X"]},"acknowledgement":"We would like to thank Martin Ackermann, Camilo Barbosa, Nick Barton, Jonathan Bollback, Sebastian Bonhoeffer, Nick Colegrave, Calin Guet, Alex Hall, Sally Otto, Tiago Paixao, Srdjan Sarikas, Hinrich Schulenburg, Marjon de Vos and Michael Whitlock for insightful support.","oa":1,"article_processing_charge":"No","citation":{"ista":"Lagator M, Uecker H, Neve P. 2021. Adaptation at different points along antibiotic concentration gradients. Biology letters. 17(5), 20200913.","chicago":"Lagator, Mato, Hildegard Uecker, and Paul Neve. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>. Royal Society of London, 2021. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>.","apa":"Lagator, M., Uecker, H., &#38; Neve, P. (2021). Adaptation at different points along antibiotic concentration gradients. <i>Biology Letters</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>","ama":"Lagator M, Uecker H, Neve P. Adaptation at different points along antibiotic concentration gradients. <i>Biology letters</i>. 2021;17(5). doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>","short":"M. Lagator, H. Uecker, P. Neve, Biology Letters 17 (2021).","ieee":"M. Lagator, H. Uecker, and P. Neve, “Adaptation at different points along antibiotic concentration gradients,” <i>Biology letters</i>, vol. 17, no. 5. Royal Society of London, 2021.","mla":"Lagator, Mato, et al. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>, vol. 17, no. 5, 20200913, Royal Society of London, 2021, doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>."},"isi":1,"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"author":[{"full_name":"Lagator, Mato","first_name":"Mato","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","last_name":"Lagator"},{"full_name":"Uecker, Hildegard","orcid":"0000-0001-9435-2813","first_name":"Hildegard","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87","last_name":"Uecker"},{"last_name":"Neve","first_name":"Paul","full_name":"Neve, Paul"}],"quality_controlled":"1","day":"12","ec_funded":1,"publication_status":"published","title":"Adaptation at different points along antibiotic concentration gradients","corr_author":"1","has_accepted_license":"1","intvolume":"        17","abstract":[{"lang":"eng","text":"Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains."}],"publication":"Biology letters","year":"2021","issue":"5","pmid":1,"ddc":["570"],"publisher":"Royal Society of London","type":"journal_article","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2021-05-23T22:01:43Z","date_published":"2021-05-12T00:00:00Z","status":"public","department":[{"_id":"NiBa"}],"date_updated":"2026-04-02T14:02:44Z","external_id":{"pmid":[" 33975485"],"isi":["000651501400001"]},"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1098/rsbl.2020.0913","file":[{"checksum":"9c13c1f5af7609c97c741f11d293188a","access_level":"open_access","date_updated":"2021-05-25T14:09:03Z","creator":"kschuh","file_size":726759,"file_name":"2021_BiologyLetters_Lagator.pdf","file_id":"9425","relation":"main_file","date_created":"2021-05-25T14:09:03Z","content_type":"application/pdf","success":1}],"_id":"9410","article_number":"20200913","oa_version":"Published Version","file_date_updated":"2021-05-25T14:09:03Z"},{"quality_controlled":"1","day":"24","publication_status":"published","title":"Regimes of motion of magnetocapillary swimmers","has_accepted_license":"1","abstract":[{"lang":"eng","text":"The dynamics of a triangular magnetocapillary swimmer is studied using the lattice Boltzmann method. We extend on our previous work, which deals with the self-assembly and a specific type of the swimmer motion characterized by the swimmer’s maximum velocity centred around the particle’s inverse viscous time. Here, we identify additional regimes of motion. First, modifying the ratio of surface tension and magnetic forces allows to study the swimmer propagation in the regime of significantly lower frequencies mainly defined by the strength of the magnetocapillary potential. Second, introducing a constant magnetic contribution in each of the particles in addition to their magnetic moment induced by external fields leads to another regime characterized by strong in-plane swimmer reorientations that resemble experimental observations."}],"intvolume":"        44","publication":"European Physical Journal E","month":"04","scopus_import":"1","volume":44,"publication_identifier":{"eissn":["1292-895X"],"issn":["1292-8941"]},"acknowledgement":"This work was financially supported by the DFG Priority Programme SPP 1726 “Microswimmers–From Single Particle Motion to Collective Behaviour” (HA 4382/5-1). We further acknowledge the Jülich Supercomputing Centre (JSC) and the High Performance Computing Centre Stuttgart (HLRS) for the allocation of computing time.","oa":1,"citation":{"ieee":"A. Sukhov <i>et al.</i>, “Regimes of motion of magnetocapillary swimmers,” <i>European Physical Journal E</i>, vol. 44, no. 4. Springer, 2021.","mla":"Sukhov, Alexander, et al. “Regimes of Motion of Magnetocapillary Swimmers.” <i>European Physical Journal E</i>, vol. 44, no. 4, 59, Springer, 2021, doi:<a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">10.1140/epje/s10189-021-00065-2</a>.","short":"A. Sukhov, M. Hubert, G.M. Grosjean, O. Trosman, S. Ziegler, Y. Collard, N. Vandewalle, A.S. Smith, J. Harting, European Physical Journal E 44 (2021).","chicago":"Sukhov, Alexander, Maxime Hubert, Galien M Grosjean, Oleg Trosman, Sebastian Ziegler, Ylona Collard, Nicolas Vandewalle, Ana Sunčana Smith, and Jens Harting. “Regimes of Motion of Magnetocapillary Swimmers.” <i>European Physical Journal E</i>. Springer, 2021. <a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">https://doi.org/10.1140/epje/s10189-021-00065-2</a>.","ista":"Sukhov A, Hubert M, Grosjean GM, Trosman O, Ziegler S, Collard Y, Vandewalle N, Smith AS, Harting J. 2021. Regimes of motion of magnetocapillary swimmers. European Physical Journal E. 44(4), 59.","ama":"Sukhov A, Hubert M, Grosjean GM, et al. Regimes of motion of magnetocapillary swimmers. <i>European Physical Journal E</i>. 2021;44(4). doi:<a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">10.1140/epje/s10189-021-00065-2</a>","apa":"Sukhov, A., Hubert, M., Grosjean, G. M., Trosman, O., Ziegler, S., Collard, Y., … Harting, J. (2021). Regimes of motion of magnetocapillary swimmers. <i>European Physical Journal E</i>. Springer. <a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">https://doi.org/10.1140/epje/s10189-021-00065-2</a>"},"article_processing_charge":"No","isi":1,"language":[{"iso":"eng"}],"author":[{"full_name":"Sukhov, Alexander","first_name":"Alexander","last_name":"Sukhov"},{"full_name":"Hubert, Maxime","first_name":"Maxime","last_name":"Hubert"},{"first_name":"Galien M","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","last_name":"Grosjean","full_name":"Grosjean, Galien M","orcid":"0000-0001-5154-417X"},{"full_name":"Trosman, Oleg","first_name":"Oleg","last_name":"Trosman"},{"last_name":"Ziegler","first_name":"Sebastian","full_name":"Ziegler, Sebastian"},{"full_name":"Collard, Ylona","last_name":"Collard","first_name":"Ylona"},{"last_name":"Vandewalle","first_name":"Nicolas","full_name":"Vandewalle, Nicolas"},{"full_name":"Smith, Ana Sunčana","first_name":"Ana Sunčana","last_name":"Smith"},{"first_name":"Jens","last_name":"Harting","full_name":"Harting, Jens"}],"department":[{"_id":"ScWa"}],"date_updated":"2025-07-10T12:01:45Z","external_id":{"isi":["000643251300001"]},"doi":"10.1140/epje/s10189-021-00065-2","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_number":"59","_id":"9411","file":[{"creator":"kschuh","file_size":2507870,"file_name":"2021_EPJE_Sukhov.pdf","file_id":"9422","checksum":"0ef342d011afbe3c5cb058fda9a3f395","access_level":"open_access","date_updated":"2021-05-25T11:32:14Z","date_created":"2021-05-25T11:32:14Z","content_type":"application/pdf","success":1,"relation":"main_file"}],"oa_version":"Published Version","file_date_updated":"2021-05-25T11:32:14Z","year":"2021","issue":"4","ddc":["530"],"publisher":"Springer","type":"journal_article","date_created":"2021-05-23T22:01:44Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2021-04-24T00:00:00Z","status":"public"},{"author":[{"first_name":"Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","last_name":"Cipolloni","full_name":"Cipolloni, Giorgio","orcid":"0000-0002-4901-7992"},{"last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"last_name":"Schröder","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","orcid":"0000-0002-2904-1856","full_name":"Schröder, Dominik J"}],"project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"language":[{"iso":"eng"}],"citation":{"mla":"Cipolloni, Giorgio, et al. “Fluctuation around the Circular Law for Random Matrices with Real Entries.” <i>Electronic Journal of Probability</i>, vol. 26, 24, Institute of Mathematical Statistics, 2021, doi:<a href=\"https://doi.org/10.1214/21-EJP591\">10.1214/21-EJP591</a>.","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Fluctuation around the circular law for random matrices with real entries,” <i>Electronic Journal of Probability</i>, vol. 26. Institute of Mathematical Statistics, 2021.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Electronic Journal of Probability 26 (2021).","ama":"Cipolloni G, Erdös L, Schröder DJ. Fluctuation around the circular law for random matrices with real entries. <i>Electronic Journal of Probability</i>. 2021;26. doi:<a href=\"https://doi.org/10.1214/21-EJP591\">10.1214/21-EJP591</a>","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2021). Fluctuation around the circular law for random matrices with real entries. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/21-EJP591\">https://doi.org/10.1214/21-EJP591</a>","ista":"Cipolloni G, Erdös L, Schröder DJ. 2021. Fluctuation around the circular law for random matrices with real entries. Electronic Journal of Probability. 26, 24.","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Fluctuation around the Circular Law for Random Matrices with Real Entries.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2021. <a href=\"https://doi.org/10.1214/21-EJP591\">https://doi.org/10.1214/21-EJP591</a>."},"article_processing_charge":"No","isi":1,"oa":1,"arxiv":1,"publication_identifier":{"eissn":["1083-6489"]},"volume":26,"month":"03","scopus_import":"1","publication":"Electronic Journal of Probability","intvolume":"        26","abstract":[{"lang":"eng","text":"We extend our recent result [22] on the central limit theorem for the linear eigenvalue statistics of non-Hermitian matrices X with independent, identically distributed complex entries to the real symmetry class. We find that the expectation and variance substantially differ from their complex counterparts, reflecting (i) the special spectral symmetry of real matrices onto the real axis; and (ii) the fact that real i.i.d. matrices have many real eigenvalues. Our result generalizes the previously known special cases where either the test function is analytic [49] or the first four moments of the matrix elements match the real Gaussian [59, 44]. The key element of the proof is the analysis of several weakly dependent Dyson Brownian motions (DBMs). The conceptual novelty of the real case compared with [22] is that the correlation structure of the stochastic differentials in each individual DBM is non-trivial, potentially even jeopardising its well-posedness."}],"has_accepted_license":"1","title":"Fluctuation around the circular law for random matrices with real entries","publication_status":"published","ec_funded":1,"day":"23","quality_controlled":"1","status":"public","date_published":"2021-03-23T00:00:00Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_created":"2021-05-23T22:01:44Z","type":"journal_article","publisher":"Institute of Mathematical Statistics","ddc":["510"],"year":"2021","file_date_updated":"2021-05-25T13:24:19Z","oa_version":"Published Version","article_number":"24","_id":"9412","file":[{"content_type":"application/pdf","success":1,"date_created":"2021-05-25T13:24:19Z","relation":"main_file","file_id":"9423","file_name":"2021_EJP_Cipolloni.pdf","file_size":865148,"creator":"kschuh","date_updated":"2021-05-25T13:24:19Z","access_level":"open_access","checksum":"864ab003ad4cffea783f65aa8c2ba69f"}],"doi":"10.1214/21-EJP591","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"isi":["000641855600001"],"arxiv":["2002.02438"]},"date_updated":"2026-04-02T14:00:37Z","department":[{"_id":"LaEr"}]},{"department":[{"_id":"MaLo"}],"external_id":{"isi":["000641574700005"],"pmid":["33439671"]},"date_updated":"2026-06-18T19:52:16Z","doi":"10.1091/MBC.E20-11-0723","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/3.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (3.0)","name":"Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)"},"oa_version":"Published Version","_id":"9414","issue":"9","pmid":1,"ddc":["570"],"license":"https://creativecommons.org/licenses/by-nc-sa/3.0/","year":"2021","publisher":"American Society for Cell Biology","article_type":"original","type":"journal_article","date_created":"2021-05-23T22:01:45Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2021-04-19T00:00:00Z","status":"public","main_file_link":[{"url":"https://www.molbiolcell.org/doi/10.1091/mbc.E20-11-0723","open_access":"1"}],"day":"19","quality_controlled":"1","ec_funded":1,"intvolume":"        32","abstract":[{"lang":"eng","text":"Microtubule plus-end depolymerization rate is a potentially important target of physiological regulation, but it has been challenging to measure, so its role in spatial organization is poorly understood. Here we apply a method for tracking plus ends based on time difference imaging to measure depolymerization rates in large interphase asters growing in Xenopus egg extract. We observed strong spatial regulation of depolymerization rates, which were higher in the aster interior compared with the periphery, and much less regulation of polymerization or catastrophe rates. We interpret these data in terms of a limiting component model, where aster growth results in lower levels of soluble tubulin and microtubule-associated proteins (MAPs) in the interior cytosol compared with that at the periphery. The steady-state polymer fraction of tubulin was ∼30%, so tubulin is not strongly depleted in the aster interior. We propose that the limiting component for microtubule assembly is a MAP that inhibits depolymerization, and that egg asters are tuned to low microtubule density."}],"publication":"Molecular Biology of the Cell","title":"Spatial variation of microtubule depolymerization in large asters","publication_status":"published","month":"04","scopus_import":"1","volume":32,"publication_identifier":{"eissn":["1939-4586"],"issn":["1059-1524"]},"oa":1,"acknowledgement":"The authors thank the members of Mitchison, Brugués, and Jay Gatlin groups (University of Wyoming) for discussions. We thank Heino Andreas (MPI-CBG) for frog maintenance. We thank Nikon for microscopy support at Marine Biological Laboratory (MBL). K.I. was supported by fellowships from the Honjo International Scholarship Foundation and Center of Systems Biology Dresden. F.D. was supported by the DIGGS-BB fellowship provided by the German Research Foundation (DFG). P.C. is supported by a Boehringer Ingelheim Fonds PhD fellowship. J.F.P. was supported by a fellowship from the Fannie and John Hertz Foundation. M.L.’s research is supported by European Research Council (ERC) Grant no. ERC-2015-StG-679239. J.B.’s research is supported by the Human Frontiers Science Program (CDA00074/2014). T.J.M.’s research is supported by National Institutes of Health Grant no. R35GM131753.","language":[{"iso":"eng"}],"project":[{"_id":"2595697A-B435-11E9-9278-68D0E5697425","name":"Self-Organization of the Bacterial Cell","call_identifier":"H2020","grant_number":"679239"},{"name":"Reconstitution of Bacterial Cell Division Using Purified Components","_id":"260D98C8-B435-11E9-9278-68D0E5697425"}],"author":[{"full_name":"Ishihara, Keisuke","first_name":"Keisuke","last_name":"Ishihara"},{"last_name":"Decker","first_name":"Franziska","full_name":"Decker, Franziska"},{"first_name":"Paulo R","id":"38FCDB4C-F248-11E8-B48F-1D18A9856A87","last_name":"Dos Santos Caldas","full_name":"Dos Santos Caldas, Paulo R","orcid":"0000-0001-6730-4461"},{"full_name":"Pelletier, James F.","first_name":"James F.","last_name":"Pelletier"},{"id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","last_name":"Loose","full_name":"Loose, Martin","orcid":"0000-0001-7309-9724"},{"full_name":"Brugués, Jan","last_name":"Brugués","first_name":"Jan"},{"full_name":"Mitchison, Timothy J.","first_name":"Timothy J.","last_name":"Mitchison"}],"isi":1,"article_processing_charge":"No","citation":{"mla":"Ishihara, Keisuke, et al. “Spatial Variation of Microtubule Depolymerization in Large Asters.” <i>Molecular Biology of the Cell</i>, vol. 32, no. 9, American Society for Cell Biology, 2021, pp. 869–79, doi:<a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">10.1091/MBC.E20-11-0723</a>.","ieee":"K. Ishihara <i>et al.</i>, “Spatial variation of microtubule depolymerization in large asters,” <i>Molecular Biology of the Cell</i>, vol. 32, no. 9. American Society for Cell Biology, pp. 869–879, 2021.","short":"K. Ishihara, F. Decker, P.R. Dos Santos Caldas, J.F. Pelletier, M. Loose, J. Brugués, T.J. Mitchison, Molecular Biology of the Cell 32 (2021) 869–879.","ama":"Ishihara K, Decker F, Dos Santos Caldas PR, et al. Spatial variation of microtubule depolymerization in large asters. <i>Molecular Biology of the Cell</i>. 2021;32(9):869-879. doi:<a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">10.1091/MBC.E20-11-0723</a>","apa":"Ishihara, K., Decker, F., Dos Santos Caldas, P. R., Pelletier, J. F., Loose, M., Brugués, J., &#38; Mitchison, T. J. (2021). Spatial variation of microtubule depolymerization in large asters. <i>Molecular Biology of the Cell</i>. American Society for Cell Biology. <a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">https://doi.org/10.1091/MBC.E20-11-0723</a>","ista":"Ishihara K, Decker F, Dos Santos Caldas PR, Pelletier JF, Loose M, Brugués J, Mitchison TJ. 2021. Spatial variation of microtubule depolymerization in large asters. Molecular Biology of the Cell. 32(9), 869–879.","chicago":"Ishihara, Keisuke, Franziska Decker, Paulo R Dos Santos Caldas, James F. Pelletier, Martin Loose, Jan Brugués, and Timothy J. Mitchison. “Spatial Variation of Microtubule Depolymerization in Large Asters.” <i>Molecular Biology of the Cell</i>. American Society for Cell Biology, 2021. <a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">https://doi.org/10.1091/MBC.E20-11-0723</a>."},"page":"869-879"},{"oa_version":"Published Version","file_date_updated":"2021-06-09T15:21:14Z","_id":"9431","file":[{"file_size":6166295,"file_name":"2021_NatureCommunications_Obr.pdf","file_id":"9538","creator":"kschuh","access_level":"open_access","date_updated":"2021-06-09T15:21:14Z","checksum":"53ccc53d09a9111143839dbe7784e663","date_created":"2021-06-09T15:21:14Z","success":1,"content_type":"application/pdf","relation":"main_file"}],"article_number":"3226","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1038/s41467-021-23506-0","external_id":{"isi":["000659145000011"]},"date_updated":"2025-04-15T08:24:49Z","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/how-retroviruses-become-infectious/","description":"News on IST Homepage"}]},"department":[{"_id":"FlSc"}],"date_published":"2021-05-28T00:00:00Z","status":"public","date_created":"2021-05-28T14:25:50Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"publisher":"Nature Research","type":"journal_article","article_type":"original","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"issue":"1","ddc":["570"],"year":"2021","intvolume":"        12","abstract":[{"text":"Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. We report here that IP6 is also used for assembly of Rous sarcoma virus (RSV), a retrovirus from a different genus. IP6 is ~100-fold more potent at promoting RSV mature capsid protein (CA) assembly than observed for HIV-1 and removal of IP6 in cells reduces infectivity by 100-fold. Here, visualized by cryo-electron tomography and subtomogram averaging, mature capsid-like particles show an IP6-like density in the CA hexamer, coordinated by rings of six lysines and six arginines. Phosphate and IP6 have opposing effects on CA in vitro assembly, inducing formation of T = 1 icosahedrons and tubes, respectively, implying that phosphate promotes pentamer and IP6 hexamer formation. Subtomogram averaging and classification optimized for analysis of pleomorphic retrovirus particles reveal that the heterogeneity of mature RSV CA polyhedrons results from an unexpected, intrinsic CA hexamer flexibility. In contrast, the CA pentamer forms rigid units organizing the local architecture. These different features of hexamers and pentamers determine the structural mechanism to form CA polyhedrons of variable shape in mature RSV particles.","lang":"eng"}],"publication":"Nature Communications","title":"Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer","publication_status":"published","corr_author":"1","has_accepted_license":"1","day":"28","quality_controlled":"1","project":[{"grant_number":"P31445","_id":"26736D6A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Structural conservation and diversity in retroviral capsid"}],"language":[{"iso":"eng"}],"author":[{"full_name":"Obr, Martin","orcid":"0000-0003-1756-6564","id":"4741CA5A-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","last_name":"Obr"},{"first_name":"Clifton L.","last_name":"Ricana","full_name":"Ricana, Clifton L."},{"full_name":"Nikulin, Nadia","last_name":"Nikulin","first_name":"Nadia"},{"last_name":"Feathers","first_name":"Jon-Philip R.","full_name":"Feathers, Jon-Philip R."},{"last_name":"Klanschnig","first_name":"Marco","full_name":"Klanschnig, Marco"},{"full_name":"Thader, Andreas","last_name":"Thader","id":"3A18A7B8-F248-11E8-B48F-1D18A9856A87","first_name":"Andreas"},{"full_name":"Johnson, Marc C.","first_name":"Marc C.","last_name":"Johnson"},{"first_name":"Volker M.","last_name":"Vogt","full_name":"Vogt, Volker M."},{"first_name":"Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078"},{"full_name":"Dick, Robert A.","first_name":"Robert A.","last_name":"Dick"}],"article_processing_charge":"No","isi":1,"citation":{"short":"M. Obr, C.L. Ricana, N. Nikulin, J.-P.R. Feathers, M. Klanschnig, A. Thader, M.C. Johnson, V.M. Vogt, F.K. Schur, R.A. Dick, Nature Communications 12 (2021).","apa":"Obr, M., Ricana, C. L., Nikulin, N., Feathers, J.-P. R., Klanschnig, M., Thader, A., … Dick, R. A. (2021). Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>","ama":"Obr M, Ricana CL, Nikulin N, et al. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>","ista":"Obr M, Ricana CL, Nikulin N, Feathers J-PR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FK, Dick RA. 2021. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. Nature Communications. 12(1), 3226.","chicago":"Obr, Martin, Clifton L. Ricana, Nadia Nikulin, Jon-Philip R. Feathers, Marco Klanschnig, Andreas Thader, Marc C. Johnson, Volker M. Vogt, Florian KM Schur, and Robert A. Dick. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>.","mla":"Obr, Martin, et al. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>, vol. 12, no. 1, 3226, Nature Research, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>.","ieee":"M. Obr <i>et al.</i>, “Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer,” <i>Nature Communications</i>, vol. 12, no. 1. Nature Research, 2021."},"oa":1,"acknowledgement":"This work was funded by the National Institute of Allergy and Infectious Diseases under awards R01AI147890 to R.A.D., R01AI150454 to V.M.V, R35GM136258 in support of J-P.R.F, and the Austrian Science Fund (FWF) grant P31445 to F.K.M.S. Access to high-resolution cryo-ET data acquisition at EMBL Heidelberg was supported by iNEXT (grant no. 653706), funded by the Horizon 2020 program of the European Union (PID 4246). We thank Wim Hagen and Felix Weis at EMBL Heidelberg for support in cryo-ET data acquisition. This work made use of the Cornell Center for Materials Research Shared Facilities, which are supported through the NSF MRSEC program (DMR-179875). This research was also supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), and the Electron Microscopy Facility (EMF).","publication_identifier":{"eissn":["2041-1723"]},"month":"05","scopus_import":"1","volume":12}]