[{"doi":"10.15479/AT:ISTA:th_1026","alternative_title":["ISTA Thesis"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher":"Institute of Science and Technology Austria","publication_status":"published","date_published":"2018-06-11T00:00:00Z","oa":1,"status":"public","date_updated":"2026-07-29T13:24:38Z","author":[{"id":"41B58C0C-F248-11E8-B48F-1D18A9856A87","first_name":"Mabel","full_name":"Iglesias Ham, Mabel","last_name":"Iglesias Ham"}],"month":"06","title":"Multiple covers with balls","file_date_updated":"2020-07-14T12:45:24Z","oa_version":"Published Version","abstract":[{"text":"We describe arrangements of three-dimensional spheres from a geometrical and topological point of view. Real data (fitting this setup) often consist of soft spheres which show certain degree of deformation while strongly packing against each other. In this context, we answer the following questions: If we model a soft packing of spheres by hard spheres that are allowed to overlap, can we measure the volume in the overlapped areas? Can we be more specific about the overlap volume, i.e. quantify how much volume is there covered exactly twice, three times, or k times? What would be a good optimization criteria that rule the arrangement of soft spheres while making a good use of the available space? Fixing a particular criterion, what would be the optimal sphere configuration? The first result of this thesis are short formulas for the computation of volumes covered by at least k of the balls. The formulas exploit information contained in the order-k Voronoi diagrams and its closely related Level-k complex. The used complexes lead to a natural generalization into poset diagrams, a theoretical formalism that contains the order-k and degree-k diagrams as special cases. In parallel, we define different criteria to determine what could be considered an optimal arrangement from a geometrical point of view. Fixing a criterion, we find optimal soft packing configurations in 2D and 3D where the ball centers lie on a lattice. As a last step, we use tools from computational topology on real physical data, to show the potentials of higher-order diagrams in the description of melting crystals. The results of the experiments leaves us with an open window to apply the theories developed in this thesis in real applications.","lang":"eng"}],"ddc":["514","516"],"year":"2018","degree_awarded":"PhD","type":"dissertation","article_processing_charge":"No","department":[{"_id":"HeEd"},{"_id":"GradSch"}],"doi_confirm":"1","OA_place":"publisher","page":"171","date_created":"2018-12-11T11:45:10Z","citation":{"mla":"Iglesias Ham, Mabel. <i>Multiple Covers with Balls</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1026\">10.15479/AT:ISTA:th_1026</a>.","apa":"Iglesias Ham, M. (2018). <i>Multiple covers with balls</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1026\">https://doi.org/10.15479/AT:ISTA:th_1026</a>","ama":"Iglesias Ham M. Multiple covers with balls. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1026\">10.15479/AT:ISTA:th_1026</a>","chicago":"Iglesias Ham, Mabel. “Multiple Covers with Balls.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1026\">https://doi.org/10.15479/AT:ISTA:th_1026</a>.","ista":"Iglesias Ham M. 2018. Multiple covers with balls. Institute of Science and Technology Austria.","ieee":"M. Iglesias Ham, “Multiple covers with balls,” Institute of Science and Technology Austria, 2018.","short":"M. Iglesias Ham, Multiple Covers with Balls, Institute of Science and Technology Austria, 2018."},"corr_author":"1","file":[{"creator":"kschuh","relation":"source_file","file_name":"IST-2018-1025-v2+5_ist-thesis-iglesias-11June2018(1).zip","access_level":"closed","date_updated":"2020-07-14T12:45:24Z","date_created":"2019-02-05T07:43:31Z","content_type":"application/zip","file_size":11827713,"file_id":"5918","checksum":"dd699303623e96d1478a6ae07210dd05"},{"creator":"kschuh","relation":"main_file","file_name":"IST-2018-1025-v2+4_ThesisIglesiasFinal11June2018.pdf","access_level":"open_access","date_updated":"2020-07-14T12:45:24Z","date_created":"2019-02-05T07:43:45Z","content_type":"application/pdf","file_size":4783846,"file_id":"5919","checksum":"ba163849a190d2b41d66fef0e4983294"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_1026","supervisor":[{"last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","orcid":"0000-0002-9823-6833"}],"language":[{"iso":"eng"}],"publist_id":"7712","_id":"201","publication_identifier":{"issn":["2663-337X"]},"has_accepted_license":"1","pubrep_id":"1026","day":"11"},{"date_updated":"2026-07-29T13:31:12Z","oa":1,"status":"public","month":"09","title":"Learning from dependent data","author":[{"id":"37099E9C-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander","full_name":"Zimin, Alexander","last_name":"Zimin"}],"file_date_updated":"2020-07-14T12:47:40Z","abstract":[{"lang":"eng","text":"The most common assumption made in statistical learning theory is the assumption of the independent and identically distributed (i.i.d.) data. While being very convenient mathematically, it is often very clearly violated in practice. This disparity between the machine learning theory and applications underlies a growing demand in the development of algorithms that learn from dependent data and theory that can provide generalization guarantees similar to the independent situations. This thesis is dedicated to two variants of dependencies that can arise in practice. One is a dependence on the level of samples in a single learning task. Another dependency type arises in the multi-task setting when the tasks are dependent on each other even though the data for them can be i.i.d. In both cases we model the data (samples or tasks) as stochastic processes and introduce new algorithms for both settings that take into account and exploit the resulting dependencies. We prove the theoretical guarantees on the performance of the introduced algorithms under different evaluation criteria and, in addition, we compliment the theoretical study by the empirical one, where we evaluate some of the algorithms on two real world datasets to highlight their practical applicability."}],"oa_version":"Published Version","ddc":["004","519"],"year":"2018","degree_awarded":"PhD","doi":"10.15479/AT:ISTA:TH1048","alternative_title":["ISTA Thesis"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","project":[{"name":"Lifelong Learning of Visual Scene Understanding","_id":"2532554C-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"308036"}],"publisher":"Institute of Science and Technology Austria","publication_status":"published","date_published":"2018-09-01T00:00:00Z","file":[{"checksum":"e849dd40a915e4d6c5572b51b517f098","file_id":"6253","file_size":1036137,"date_created":"2019-04-09T07:32:47Z","content_type":"application/pdf","date_updated":"2020-07-14T12:47:40Z","access_level":"open_access","file_name":"2018_Thesis_Zimin.pdf","creator":"dernst","relation":"main_file"},{"checksum":"da092153cec55c97461bd53c45c5d139","file_id":"6254","file_size":637490,"date_created":"2019-04-09T07:32:47Z","content_type":"application/zip","date_updated":"2020-07-14T12:47:40Z","access_level":"closed","file_name":"2018_Thesis_Zimin_Source.zip","creator":"dernst","relation":"source_file"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:TH1048","publist_id":"7986","language":[{"iso":"eng"}],"supervisor":[{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","orcid":"0000-0001-8622-7887","last_name":"Lampert","full_name":"Lampert, Christoph"}],"publication_identifier":{"issn":["2663-337X"]},"_id":"68","has_accepted_license":"1","day":"01","pubrep_id":"1048","ec_funded":1,"department":[{"_id":"ChLa"},{"_id":"GradSch"}],"article_processing_charge":"No","type":"dissertation","doi_confirm":"1","OA_place":"publisher","page":"92","citation":{"mla":"Zimin, Alexander. <i>Learning from Dependent Data</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH1048\">10.15479/AT:ISTA:TH1048</a>.","chicago":"Zimin, Alexander. “Learning from Dependent Data.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH1048\">https://doi.org/10.15479/AT:ISTA:TH1048</a>.","apa":"Zimin, A. (2018). <i>Learning from dependent data</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH1048\">https://doi.org/10.15479/AT:ISTA:TH1048</a>","ama":"Zimin A. Learning from dependent data. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH1048\">10.15479/AT:ISTA:TH1048</a>","ieee":"A. Zimin, “Learning from dependent data,” Institute of Science and Technology Austria, 2018.","short":"A. Zimin, Learning from Dependent Data, Institute of Science and Technology Austria, 2018.","ista":"Zimin A. 2018. Learning from dependent data. Institute of Science and Technology Austria."},"date_created":"2018-12-11T11:44:27Z","corr_author":"1"},{"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","project":[{"grant_number":"259668","call_identifier":"FP7","_id":"258C570E-B435-11E9-9278-68D0E5697425","name":"Provable Security for Physical Cryptography"},{"grant_number":"682815","call_identifier":"H2020","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","name":"Teaching Old Crypto New Tricks"}],"publisher":"Institute of Science and Technology Austria","doi":"10.15479/AT:ISTA:TH_1046","alternative_title":["ISTA Thesis"],"publication_status":"published","date_published":"2018-09-05T00:00:00Z","file_date_updated":"2020-07-14T12:48:11Z","date_updated":"2026-07-29T13:38:08Z","oa":1,"status":"public","month":"09","title":"Proof systems for sustainable decentralized cryptocurrencies","author":[{"last_name":"Abusalah","full_name":"Abusalah, Hamza M","id":"40297222-F248-11E8-B48F-1D18A9856A87","first_name":"Hamza M"}],"year":"2018","degree_awarded":"PhD","abstract":[{"text":"A proof system is a protocol between a prover and a verifier over a common input in which an honest prover convinces the verifier of the validity of true statements. Motivated by the success of decentralized cryptocurrencies, exemplified by Bitcoin, the focus of this thesis will be on proof systems which found applications in some sustainable alternatives to Bitcoin, such as the Spacemint and Chia cryptocurrencies. In particular, we focus on proofs of space and proofs of sequential work.\r\nProofs of space (PoSpace) were suggested as more ecological, economical, and egalitarian alternative to the energy-wasteful proof-of-work mining of Bitcoin. However, the state-of-the-art constructions of PoSpace are based on sophisticated graph pebbling lower bounds, and are therefore complex. Moreover, when these PoSpace are used in cryptocurrencies like Spacemint, miners can only start mining after ensuring that a commitment to their space is already added in a special transaction to the blockchain. Proofs of sequential work (PoSW) are proof systems in which a prover, upon receiving a statement x and a time parameter T, computes a proof which convinces the verifier that T time units had passed since x was received. Whereas Spacemint assumes synchrony to retain some interesting Bitcoin dynamics, Chia requires PoSW with unique proofs, i.e., PoSW in which it is hard to come up with more than one accepting proof for any true statement. In this thesis we construct simple and practically-efficient PoSpace and PoSW. When using our PoSpace in cryptocurrencies, miners can start mining on the fly, like in Bitcoin, and unlike current constructions of PoSW, which either achieve efficient verification of sequential work, or faster-than-recomputing verification of correctness of proofs, but not both at the same time, ours achieve the best of these two worlds.","lang":"eng"}],"oa_version":"Published Version","ddc":["004"],"department":[{"_id":"KrPi"},{"_id":"GradSch"}],"type":"dissertation","article_processing_charge":"No","doi_confirm":"1","related_material":{"record":[{"relation":"part_of_dissertation","id":"559","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"1236"},{"status":"public","relation":"part_of_dissertation","id":"1235"},{"status":"public","relation":"part_of_dissertation","id":"1229"}]},"ec_funded":1,"citation":{"ista":"Abusalah HM. 2018. Proof systems for sustainable decentralized cryptocurrencies. Institute of Science and Technology Austria.","short":"H.M. Abusalah, Proof Systems for Sustainable Decentralized Cryptocurrencies, Institute of Science and Technology Austria, 2018.","ieee":"H. M. Abusalah, “Proof systems for sustainable decentralized cryptocurrencies,” Institute of Science and Technology Austria, 2018.","chicago":"Abusalah, Hamza M. “Proof Systems for Sustainable Decentralized Cryptocurrencies.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1046\">https://doi.org/10.15479/AT:ISTA:TH_1046</a>.","ama":"Abusalah HM. Proof systems for sustainable decentralized cryptocurrencies. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1046\">10.15479/AT:ISTA:TH_1046</a>","apa":"Abusalah, H. M. (2018). <i>Proof systems for sustainable decentralized cryptocurrencies</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1046\">https://doi.org/10.15479/AT:ISTA:TH_1046</a>","mla":"Abusalah, Hamza M. <i>Proof Systems for Sustainable Decentralized Cryptocurrencies</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1046\">10.15479/AT:ISTA:TH_1046</a>."},"date_created":"2018-12-11T11:44:32Z","corr_author":"1","OA_place":"publisher","page":"59","fulldoi":"https://doi.org/10.15479/AT:ISTA:TH_1046","file":[{"checksum":"c4b5f7d111755d1396787f41886fc674","content_type":"application/pdf","date_created":"2019-04-09T06:43:41Z","file_id":"6245","file_size":876241,"date_updated":"2020-07-14T12:48:11Z","file_name":"2018_Thesis_Abusalah.pdf","creator":"dernst","relation":"main_file","access_level":"open_access"},{"date_updated":"2020-07-14T12:48:11Z","file_name":"2018_Thesis_Abusalah_source.tar.gz","creator":"dernst","relation":"source_file","access_level":"closed","checksum":"0f382ac56b471c48fd907d63eb87dafe","date_created":"2019-04-09T06:43:41Z","content_type":"application/x-gzip","file_id":"6246","file_size":2029190}],"publication_identifier":{"issn":["2663-337X"]},"_id":"83","day":"05","has_accepted_license":"1","pubrep_id":"1046","publist_id":"7971","language":[{"iso":"eng"}],"supervisor":[{"orcid":"0000-0002-9139-1654","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z","full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak"}]},{"abstract":[{"lang":"eng","text":"We prove a new central limit theorem (CLT) for the difference of linear eigenvalue statistics of a Wigner random matrix H and its minor H and find that the fluctuation is much smaller than the fluctuations of the individual linear statistics, as a consequence of the strong correlation between the eigenvalues of H and H. In particular, our theorem identifies the fluctuation of Kerov's rectangular Young diagrams, defined by the interlacing eigenvalues ofH and H, around their asymptotic shape, the Vershik'Kerov'Logan'Shepp curve. Young diagrams equipped with the Plancherel measure follow the same limiting shape. For this, algebraically motivated, ensemble a CLT has been obtained in Ivanov and Olshanski [20] which is structurally similar to our result but the variance is different, indicating that the analogy between the two models has its limitations. Moreover, our theorem shows that Borodin's result [7] on the convergence of the spectral distribution of Wigner matrices to a Gaussian free field also holds in derivative sense."}],"oa_version":"Preprint","isi":1,"publication":"International Mathematics Research Notices","year":"2018","scopus_import":"1","title":"Fluctuations of rectangular young diagrams of interlacing wigner eigenvalues","month":"05","issue":"10","author":[{"full_name":"Erdös, László","last_name":"Erdös","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","full_name":"Schröder, Dominik J","last_name":"Schröder"}],"date_updated":"2026-07-29T13:46:19Z","status":"public","oa":1,"date_published":"2018-05-18T00:00:00Z","intvolume":"      2018","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1608.05163"}],"arxiv":1,"doi":"10.1093/imrn/rnw330","project":[{"name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"}],"publisher":"Oxford University Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"6383","quality_controlled":"1","language":[{"iso":"eng"}],"day":"18","publication_identifier":{"issn":["1073-7928"]},"_id":"1012","external_id":{"arxiv":["1608.05163"],"isi":["000441668300009"]},"fulldoi":"https://doi.org/10.1093/imrn/rnw330","page":"3255-3298","volume":2018,"citation":{"mla":"Erdös, László, and Dominik J. Schröder. “Fluctuations of Rectangular Young Diagrams of Interlacing Wigner Eigenvalues.” <i>International Mathematics Research Notices</i>, vol. 2018, no. 10, Oxford University Press, 2018, pp. 3255–98, doi:<a href=\"https://doi.org/10.1093/imrn/rnw330\">10.1093/imrn/rnw330</a>.","chicago":"Erdös, László, and Dominik J Schröder. “Fluctuations of Rectangular Young Diagrams of Interlacing Wigner Eigenvalues.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2018. <a href=\"https://doi.org/10.1093/imrn/rnw330\">https://doi.org/10.1093/imrn/rnw330</a>.","apa":"Erdös, L., &#38; Schröder, D. J. (2018). Fluctuations of rectangular young diagrams of interlacing wigner eigenvalues. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rnw330\">https://doi.org/10.1093/imrn/rnw330</a>","ama":"Erdös L, Schröder DJ. Fluctuations of rectangular young diagrams of interlacing wigner eigenvalues. <i>International Mathematics Research Notices</i>. 2018;2018(10):3255-3298. doi:<a href=\"https://doi.org/10.1093/imrn/rnw330\">10.1093/imrn/rnw330</a>","ista":"Erdös L, Schröder DJ. 2018. Fluctuations of rectangular young diagrams of interlacing wigner eigenvalues. International Mathematics Research Notices. 2018(10), 3255–3298.","ieee":"L. Erdös and D. J. Schröder, “Fluctuations of rectangular young diagrams of interlacing wigner eigenvalues,” <i>International Mathematics Research Notices</i>, vol. 2018, no. 10. Oxford University Press, pp. 3255–3298, 2018.","short":"L. Erdös, D.J. Schröder, International Mathematics Research Notices 2018 (2018) 3255–3298."},"date_created":"2018-12-11T11:49:41Z","ec_funded":1,"related_material":{"record":[{"id":"6179","relation":"dissertation_contains","status":"public"}]},"department":[{"_id":"LaEr"}],"type":"journal_article","article_processing_charge":"No"},{"publication_status":"published","date_published":"2018-07-30T00:00:00Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","publisher":"Institute of Science and Technology Austria","doi":"10.15479/AT:ISTA:th_1033","alternative_title":["ISTA Thesis"],"year":"2018","degree_awarded":"PhD","abstract":[{"text":"Nowadays, quantum computation is receiving more and more attention as an alternative to the classical way of computing. For realizing a quantum computer, different devices are investigated as potential quantum bits. In this thesis, the focus is on Ge hut wires, which turned out to be promising candidates for implementing hole spin quantum bits. The advantages of Ge as a material system are the low hyperfine interaction for holes and the strong spin orbit coupling, as well as the compatibility with the highly developed CMOS processes in industry. In addition, Ge can also be isotopically purified which is expected to boost the spin coherence times. The strong spin orbit interaction for holes in Ge on the one hand enables the full electrical control of the quantum bit and on the other hand should allow short spin manipulation times. Starting with a bare Si wafer, this work covers the entire process reaching from growth over the fabrication and characterization of hut wire devices up to the demonstration of hole spin resonance. From experiments with single quantum dots, a large g-factor anisotropy between the in-plane and the out-of-plane direction was found. A comparison to a theoretical model unveiled the heavy-hole character of the lowest energy states. The second part of the thesis addresses double quantum dot devices, which were realized by adding two gate electrodes to a hut wire. In such devices, Pauli spin blockade was observed, which can serve as a read-out mechanism for spin quantum bits. Applying oscillating electric fields in spin blockade allowed the demonstration of continuous spin rotations and the extraction of a lower bound for the spin dephasing time. Despite the strong spin orbit coupling in Ge, the obtained value for the dephasing time is comparable to what has been recently reported for holes in Si. All in all, the presented results point out the high potential of Ge hut wires as a platform for long-lived, fast and fully electrically tunable hole spin quantum bits.","lang":"eng"}],"oa_version":"Published Version","ddc":["530"],"file_date_updated":"2020-07-14T12:46:35Z","date_updated":"2026-07-31T09:15:25Z","status":"public","oa":1,"title":"Ge hut wires - from growth to hole spin resonance","month":"07","author":[{"last_name":"Watzinger","full_name":"Watzinger, Hannes","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87","first_name":"Hannes"}],"citation":{"mla":"Watzinger, Hannes. <i>Ge Hut Wires - from Growth to Hole Spin Resonance</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>.","chicago":"Watzinger, Hannes. “Ge Hut Wires - from Growth to Hole Spin Resonance.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>.","ama":"Watzinger H. Ge hut wires - from growth to hole spin resonance. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>","apa":"Watzinger, H. (2018). <i>Ge hut wires - from growth to hole spin resonance</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>","ista":"Watzinger H. 2018. Ge hut wires - from growth to hole spin resonance. Institute of Science and Technology Austria.","ieee":"H. Watzinger, “Ge hut wires - from growth to hole spin resonance,” Institute of Science and Technology Austria, 2018.","short":"H. Watzinger, Ge Hut Wires - from Growth to Hole Spin Resonance, Institute of Science and Technology Austria, 2018."},"date_created":"2018-12-11T11:44:21Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","OA_place":"publisher","page":"77","department":[{"_id":"GeKa"},{"_id":"GradSch"}],"type":"dissertation","article_processing_charge":"No","doi_confirm":"1","publication_identifier":{"issn":["2663-337X"]},"_id":"49","has_accepted_license":"1","day":"30","pubrep_id":"1033","publist_id":"8005","supervisor":[{"last_name":"Katsaros","full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios"}],"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_1033","file":[{"access_level":"open_access","relation":"main_file","creator":"dernst","file_name":"2018_Thesis_Watzinger.pdf","date_updated":"2020-07-14T12:46:35Z","file_size":85539748,"file_id":"6249","date_created":"2019-04-09T07:13:28Z","content_type":"application/pdf","checksum":"b653b5216251f938ddbeafd1de88667c"},{"checksum":"39bcf8de7ac5b1bb516b11ce2f966785","file_id":"6250","file_size":21830697,"content_type":"application/zip","date_created":"2019-04-09T07:13:27Z","date_updated":"2020-07-14T12:46:35Z","access_level":"closed","file_name":"2018_Thesis_Watzinger_source.zip","relation":"source_file","creator":"dernst"}]},{"external_id":{"isi":["000431721800005"],"arxiv":["1612.07776 "]},"fulldoi":"https://doi.org/10.1214/17-AAP1302","quality_controlled":"1","language":[{"iso":"eng"}],"day":"03","_id":"566","ec_funded":1,"related_material":{"record":[{"status":"public","id":"149","relation":"dissertation_contains"}]},"department":[{"_id":"LaEr"}],"article_processing_charge":"No","type":"journal_article","page":"148-203","volume":28,"corr_author":"1","citation":{"mla":"Alt, Johannes, et al. “Local Inhomogeneous Circular Law.” <i>Annals of Applied Probability</i>, vol. 28, no. 1, Institute of Mathematical Statistics, 2018, pp. 148–203, doi:<a href=\"https://doi.org/10.1214/17-AAP1302\">10.1214/17-AAP1302</a>.","apa":"Alt, J., Erdös, L., &#38; Krüger, T. H. (2018). Local inhomogeneous circular law. <i>Annals of Applied Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/17-AAP1302\">https://doi.org/10.1214/17-AAP1302</a>","ama":"Alt J, Erdös L, Krüger TH. Local inhomogeneous circular law. <i>Annals of Applied Probability</i>. 2018;28(1):148-203. doi:<a href=\"https://doi.org/10.1214/17-AAP1302\">10.1214/17-AAP1302</a>","chicago":"Alt, Johannes, László Erdös, and Torben H Krüger. “Local Inhomogeneous Circular Law.” <i>Annals of Applied Probability</i>. Institute of Mathematical Statistics, 2018. <a href=\"https://doi.org/10.1214/17-AAP1302\">https://doi.org/10.1214/17-AAP1302</a>.","ieee":"J. Alt, L. Erdös, and T. H. Krüger, “Local inhomogeneous circular law,” <i>Annals of Applied Probability</i>, vol. 28, no. 1. Institute of Mathematical Statistics, pp. 148–203, 2018.","short":"J. Alt, L. Erdös, T.H. Krüger, Annals of Applied Probability 28 (2018) 148–203.","ista":"Alt J, Erdös L, Krüger TH. 2018. Local inhomogeneous circular law. Annals of Applied Probability. 28(1), 148–203."},"date_created":"2018-12-11T11:47:13Z","scopus_import":"1","title":"Local inhomogeneous circular law","month":"03","author":[{"id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes","last_name":"Alt","full_name":"Alt, Johannes"},{"last_name":"Erdös","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4821-3297","full_name":"Krüger, Torben H","last_name":"Krüger"}],"issue":"1","date_updated":"2026-08-05T08:14:17Z","oa":1,"status":"public","article_type":"original","abstract":[{"lang":"eng","text":"We consider large random matrices X with centered, independent entries which have comparable but not necessarily identical variances. Girko's circular law asserts that the spectrum is supported in a disk and in case of identical variances, the limiting density is uniform. In this special case, the local circular law by Bourgade et. al. [11,12] shows that the empirical density converges even locally on scales slightly above the typical eigenvalue spacing. In the general case, the limiting density is typically inhomogeneous and it is obtained via solving a system of deterministic equations. Our main result is the local inhomogeneous circular law in the bulk spectrum on the optimal scale for a general variance profile of the entries of X. \r\n\r\n"}],"oa_version":"Preprint","isi":1,"das_tickbox":"1","publication":"Annals of Applied Probability","year":"2018","arxiv":1,"doi":"10.1214/17-AAP1302","project":[{"name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"}],"publisher":"Institute of Mathematical Statistics","user_id":"9947682f-b9fa-11ee-9c4a-b3ffaafe6614","date_published":"2018-03-03T00:00:00Z","intvolume":"        28","publication_status":"published","main_file_link":[{"url":"https://arxiv.org/abs/1612.07776 ","open_access":"1"}]},{"intvolume":"        15","publication_status":"published","date_published":"2018-12-05T00:00:00Z","doi":"10.1098/rsif.2018.0600","article_number":"20180600","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Royal Society","abstract":[{"text":"Spatial patterns are ubiquitous on the subcellular, cellular and tissue level, and can be studied using imaging techniques such as light and fluorescence microscopy. Imaging data provide quantitative information about biological systems; however, mechanisms causing spatial patterning often remain elusive. In recent years, spatio-temporal mathematical modelling has helped to overcome this problem. Yet, outliers and structured noise limit modelling of whole imaging data, and models often consider spatial summary statistics. Here, we introduce an integrated data-driven modelling approach that can cope with measurement artefacts and whole imaging data. Our approach combines mechanistic models of the biological processes with robust statistical models of the measurement process. The parameters of the integrated model are calibrated using a maximum-likelihood approach. We used this integrated modelling approach to study in vivo gradients of the chemokine (C-C motif) ligand 21 (CCL21). CCL21 gradients guide dendritic cells and are important in the adaptive immune response. Using artificial data, we verified that the integrated modelling approach provides reliable parameter estimates in the presence of measurement noise and that bias and variance of these estimates are reduced compared to conventional approaches. The application to experimental data allowed the parametrization and subsequent refinement of the model using additional mechanisms. Among other results, model-based hypothesis testing predicted lymphatic vessel-dependent concentration of heparan sulfate, the binding partner of CCL21. The selected model provided an accurate description of the experimental data and was partially validated using published data. Our findings demonstrate that integrated statistical modelling of whole imaging data is computationally feasible and can provide novel biological insights.","lang":"eng"}],"oa_version":"Published Version","ddc":["570"],"publication":"Journal of the Royal Society Interface","year":"2018","isi":1,"date_updated":"2026-08-12T06:28:50Z","status":"public","oa":1,"title":"Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data","month":"12","scopus_import":"1","author":[{"first_name":"Sabrina","last_name":"Hross","full_name":"Hross, Sabrina"},{"full_name":"Theis, Fabian J.","last_name":"Theis","first_name":"Fabian J."},{"last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","orcid":"0000-0002-6620-9179"},{"last_name":"Hasenauer","full_name":"Hasenauer, Jan","first_name":"Jan"}],"issue":"149","file_date_updated":"2020-07-14T12:47:13Z","volume":15,"citation":{"mla":"Hross, Sabrina, et al. “Mechanistic Description of Spatial Processes Using Integrative Modelling of Noise-Corrupted Imaging Data.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149, 20180600, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0600\">10.1098/rsif.2018.0600</a>.","chicago":"Hross, Sabrina, Fabian J. Theis, Michael K Sixt, and Jan Hasenauer. “Mechanistic Description of Spatial Processes Using Integrative Modelling of Noise-Corrupted Imaging Data.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0600\">https://doi.org/10.1098/rsif.2018.0600</a>.","ama":"Hross S, Theis FJ, Sixt MK, Hasenauer J. Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. <i>Journal of the Royal Society Interface</i>. 2018;15(149). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0600\">10.1098/rsif.2018.0600</a>","apa":"Hross, S., Theis, F. J., Sixt, M. K., &#38; Hasenauer, J. (2018). Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0600\">https://doi.org/10.1098/rsif.2018.0600</a>","ieee":"S. Hross, F. J. Theis, M. K. Sixt, and J. Hasenauer, “Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149. Royal Society, 2018.","short":"S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).","ista":"Hross S, Theis FJ, Sixt MK, Hasenauer J. 2018. Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. Journal of the Royal Society Interface. 15(149), 20180600."},"date_created":"2019-01-20T22:59:18Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"department":[{"_id":"MiSi"}],"type":"journal_article","article_processing_charge":"No","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1742-5689"]},"_id":"5858","has_accepted_license":"1","day":"05","file":[{"access_level":"open_access","file_name":"2018_Interface_Hross.pdf","relation":"main_file","creator":"dernst","date_updated":"2020-07-14T12:47:13Z","file_id":"5925","file_size":1464288,"date_created":"2019-02-05T14:46:44Z","content_type":"application/pdf","checksum":"56eb4308a15b7190bff938fab1f780e8"}],"external_id":{"isi":["000456783800011"]},"fulldoi":"https://doi.org/10.1098/rsif.2018.0600"},{"issue":"149","author":[{"last_name":"Corominas-Murtra","full_name":"Corominas-Murtra, Bernat","orcid":"0000-0001-9806-5643","id":"43BE2298-F248-11E8-B48F-1D18A9856A87","first_name":"Bernat"},{"full_name":"Seoane, Luís F.","last_name":"Seoane","first_name":"Luís F."},{"last_name":"Solé","full_name":"Solé, Ricard","first_name":"Ricard"}],"scopus_import":"1","month":"12","title":"Zipf's Law, unbounded complexity and open-ended evolution","oa":1,"status":"public","date_updated":"2026-08-12T06:28:34Z","oa_version":"Preprint","abstract":[{"lang":"eng","text":"A major problem for evolutionary theory is understanding the so-called open-ended nature of evolutionary change, from its definition to its origins. Open-ended evolution (OEE) refers to the unbounded increase in complexity that seems to characterize evolution on multiple scales. This property seems to be a characteristic feature of biological and technological evolution and is strongly tied to the generative potential associated with combinatorics, which allows the system to grow and expand their available state spaces. Interestingly, many complex systems presumably displaying OEE, from language to proteins, share a common statistical property: the presence of Zipf's Law. Given an inventory of basic items (such as words or protein domains) required to build more complex structures (sentences or proteins) Zipf's Law tells us that most of these elements are rare whereas a few of them are extremely common. Using algorithmic information theory, in this paper we provide a fundamental definition for open-endedness, which can be understood as postulates. Its statistical counterpart, based on standard Shannon information theory, has the structure of a variational problem which is shown to lead to Zipf's Law as the expected consequence of an evolutionary process displaying OEE. We further explore the problem of information conservation through an OEE process and we conclude that statistical information (standard Shannon information) is not conserved, resulting in the paradoxical situation in which the increase of information content has the effect of erasing itself. We prove that this paradox is solved if we consider non-statistical forms of information. This last result implies that standard information theory may not be a suitable theoretical framework to explore the persistence and increase of the information content in OEE systems."}],"isi":1,"year":"2018","publication":"Journal of the Royal Society Interface","arxiv":1,"article_number":"20180395","doi":"10.1098/rsif.2018.0395","publisher":"Royal Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2018-12-12T00:00:00Z","intvolume":"        15","publication_status":"published","main_file_link":[{"url":"https://arxiv.org/abs/1612.01605","open_access":"1"}],"external_id":{"arxiv":["1612.01605"],"isi":["000456783800002"]},"fulldoi":"https://doi.org/10.1098/rsif.2018.0395","language":[{"iso":"eng"}],"quality_controlled":"1","day":"12","_id":"5860","publication_identifier":{"issn":["1742-5689"]},"type":"journal_article","article_processing_charge":"No","department":[{"_id":"EdHa"}],"volume":15,"date_created":"2019-01-20T22:59:19Z","citation":{"ista":"Corominas-Murtra B, Seoane LF, Solé R. 2018. Zipf’s Law, unbounded complexity and open-ended evolution. Journal of the Royal Society Interface. 15(149), 20180395.","short":"B. Corominas-Murtra, L.F. Seoane, R. Solé, Journal of the Royal Society Interface 15 (2018).","ieee":"B. Corominas-Murtra, L. F. Seoane, and R. Solé, “Zipf’s Law, unbounded complexity and open-ended evolution,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149. Royal Society, 2018.","apa":"Corominas-Murtra, B., Seoane, L. F., &#38; Solé, R. (2018). Zipf’s Law, unbounded complexity and open-ended evolution. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0395\">https://doi.org/10.1098/rsif.2018.0395</a>","ama":"Corominas-Murtra B, Seoane LF, Solé R. Zipf’s Law, unbounded complexity and open-ended evolution. <i>Journal of the Royal Society Interface</i>. 2018;15(149). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0395\">10.1098/rsif.2018.0395</a>","chicago":"Corominas-Murtra, Bernat, Luís F. Seoane, and Ricard Solé. “Zipf’s Law, Unbounded Complexity and Open-Ended Evolution.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0395\">https://doi.org/10.1098/rsif.2018.0395</a>.","mla":"Corominas-Murtra, Bernat, et al. “Zipf’s Law, Unbounded Complexity and Open-Ended Evolution.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149, 20180395, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0395\">10.1098/rsif.2018.0395</a>."}},{"type":"journal_article","article_processing_charge":"No","department":[{"_id":"KrPi"}],"page":"17-47","volume":12,"date_created":"2019-02-13T13:49:41Z","citation":{"ama":"Chatterjee S, Kamath Hosdurg C, Kumar V. Private set-intersection with common set-up. <i>Advances in Mathematics of Communications</i>. 2018;12(1):17-47. doi:<a href=\"https://doi.org/10.3934/amc.2018002\">10.3934/amc.2018002</a>","chicago":"Chatterjee, Sanjit, Chethan Kamath Hosdurg, and Vikas Kumar. “Private Set-Intersection with Common Set-Up.” <i>Advances in Mathematics of Communications</i>. AIMS, 2018. <a href=\"https://doi.org/10.3934/amc.2018002\">https://doi.org/10.3934/amc.2018002</a>.","apa":"Chatterjee, S., Kamath Hosdurg, C., &#38; Kumar, V. (2018). Private set-intersection with common set-up. <i>Advances in Mathematics of Communications</i>. AIMS. <a href=\"https://doi.org/10.3934/amc.2018002\">https://doi.org/10.3934/amc.2018002</a>","mla":"Chatterjee, Sanjit, et al. “Private Set-Intersection with Common Set-Up.” <i>Advances in Mathematics of Communications</i>, vol. 12, no. 1, AIMS, 2018, pp. 17–47, doi:<a href=\"https://doi.org/10.3934/amc.2018002\">10.3934/amc.2018002</a>.","ista":"Chatterjee S, Kamath Hosdurg C, Kumar V. 2018. Private set-intersection with common set-up. Advances in Mathematics of Communications. 12(1), 17–47.","short":"S. Chatterjee, C. Kamath Hosdurg, V. Kumar, Advances in Mathematics of Communications 12 (2018) 17–47.","ieee":"S. Chatterjee, C. Kamath Hosdurg, and V. Kumar, “Private set-intersection with common set-up,” <i>Advances in Mathematics of Communications</i>, vol. 12, no. 1. AIMS, pp. 17–47, 2018."},"external_id":{"isi":["000430950400002"]},"fulldoi":"https://doi.org/10.3934/amc.2018002","language":[{"iso":"eng"}],"quality_controlled":"1","day":"01","_id":"5980","publication_identifier":{"issn":["1930-5346"]},"doi":"10.3934/amc.2018002","publisher":"AIMS","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2018-02-01T00:00:00Z","publication_status":"published","intvolume":"        12","issue":"1","author":[{"last_name":"Chatterjee","full_name":"Chatterjee, Sanjit","first_name":"Sanjit"},{"full_name":"Kamath Hosdurg, Chethan","last_name":"Kamath Hosdurg","id":"4BD3F30E-F248-11E8-B48F-1D18A9856A87","first_name":"Chethan","orcid":"0009-0006-6812-7317"},{"first_name":"Vikas","full_name":"Kumar, Vikas","last_name":"Kumar"}],"title":"Private set-intersection with common set-up","month":"02","scopus_import":"1","status":"public","date_updated":"2026-08-12T09:13:26Z","oa_version":"None","abstract":[{"text":"The problem of private set-intersection (PSI) has been traditionally treated as an instance of the more general problem of multi-party computation (MPC). Consequently, in order to argue security, or compose these protocols one has to rely on the general theory that was developed for the purpose of MPC. The pursuit of efficient protocols, however, has resulted in designs that exploit properties pertaining to PSI. In almost all practical applications where a PSI protocol is deployed, it is expected to be executed multiple times, possibly on related inputs. In this work we initiate a dedicated study of PSI in the multi-interaction (MI) setting. In this model a server sets up the common system parameters and executes set-intersection multiple times with potentially different clients. We discuss a few attacks that arise when protocols are naïvely composed in this manner and, accordingly, craft security definitions for the MI setting and study their inter-relation. Finally, we suggest a set of protocols that are MI-secure, at the same time almost as efficient as their parent, stand-alone, protocols.","lang":"eng"}],"isi":1,"year":"2018","publication":"Advances in Mathematics of Communications"},{"date_published":"2018-01-08T00:00:00Z","publication_status":"published","alternative_title":["ISTA Thesis"],"doi":"10.15479/AT:ISTA:th_913","publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","ddc":["571","570"],"abstract":[{"text":"The aim of this thesis was the development of new strategies for optical and optogenetic control of proliferative and pro-survival signaling, and characterizing them from the molecular mechanism up to cellular effects. These new light-based methods have unique features, such as red light as an activator, or the avoidance of gene delivery, which enable to overcome current limitations, such as light delivery to target tissues and feasibility as therapeutic approach. A special focus was placed on implementing these new light-based approaches in pancreatic β-cells, as β-cells are the key players in diabetes and especially their loss in number negatively affects disease progression. Currently no treatment options are available to compensate the lack of functional β-cells in diabetic patients.\r\nIn a first approach, red-light-activated growth factor receptors, in particular receptor tyrosine kinases were engineered and characterized. Receptor activation with light allows spatio-temporal control compared to ligand-based activation, and especially red light exhibits deeper tissue penetration than other wavelengths of the visible spectrum. Red-light-activated receptor tyrosine kinases robustly activated major growth factor related signaling pathways with a high temporal resolution. Moreover, the remote activation of the proliferative MAPK/Erk pathway by red-light-activated receptor tyrosine kinases in a pancreatic β-cell line was also achieved, through one centimeter thick mouse tissue. Although red-light-activated receptor tyrosine kinases are particularly attractive for applications in animal models due to the deep tissue penetration of red light, a drawback, especially with regard to translation into humans, is the requirement of gene therapy.\r\nIn a second approach an endogenous light-sensitive mechanism was identified and its potential to promote proliferative and pro-survival signals was explored, towards light-based tissue regeneration without the need for gene transfer. Blue-green light illumination was found to be sufficient for the activation of proliferation and survival promoting signaling pathways in primary pancreatic murine and human islets. Blue-green light also led to an increase in proliferation of primary islet cells, an effect which was shown to be mostly β-cell specific in human islets. Moreover, it was demonstrated that this approach of pancreatic β-cell expansion did not have any negative effect on the β-cell function, in particular on their insulin secretion capacity. In contrast, a trend for enhanced insulin secretion under high glucose conditions after illumination was detected. In order to unravel the detailed characteristics of this endogenous light-sensitive mechanism, the precise light requirements were determined. In addition, the expression of light sensing proteins, OPN3 and rhodopsin, was detected. The observed effects were found to be independent of handling effects such as temperature differences and cytochrome c oxidase dependent ATP increase, but they were found to be enhanced through the knockout of OPN3. The exact mechanism of how islets cells sense light and the identity of the photoreceptor remains unknown.\r\nSummarized two new light-based systems with unique features were established that enable the activation of proliferative and pro-survival signaling pathways. While red-light-activated receptor tyrosine kinases open a new avenue for optogenetics research, by allowing non-invasive control of signaling in vivo, the identified endogenous light-sensitive mechanism has the potential to be the basis of a gene therapy-free therapeutical approach for light-based β-cell expansion.","lang":"eng"}],"oa_version":"Published Version","degree_awarded":"PhD","year":"2018","title":"Optical and optogenetic control of proliferation and survival ","month":"01","author":[{"id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","orcid":"0000-0002-7218-7738","last_name":"Gschaider-Reichhart","full_name":"Gschaider-Reichhart, Eva"}],"date_updated":"2026-08-12T09:19:21Z","status":"public","oa":1,"file_date_updated":"2020-07-14T12:46:24Z","page":"107","OA_place":"publisher","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","citation":{"chicago":"Gschaider-Reichhart, Eva. “Optical and Optogenetic Control of Proliferation and Survival .” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">https://doi.org/10.15479/AT:ISTA:th_913</a>.","apa":"Gschaider-Reichhart, E. (2018). <i>Optical and optogenetic control of proliferation and survival </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">https://doi.org/10.15479/AT:ISTA:th_913</a>","ama":"Gschaider-Reichhart E. Optical and optogenetic control of proliferation and survival . 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">10.15479/AT:ISTA:th_913</a>","mla":"Gschaider-Reichhart, Eva. <i>Optical and Optogenetic Control of Proliferation and Survival </i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_913\">10.15479/AT:ISTA:th_913</a>.","short":"E. Gschaider-Reichhart, Optical and Optogenetic Control of Proliferation and Survival , Institute of Science and Technology Austria, 2018.","ieee":"E. Gschaider-Reichhart, “Optical and optogenetic control of proliferation and survival ,” Institute of Science and Technology Austria, 2018.","ista":"Gschaider-Reichhart E. 2018. Optical and optogenetic control of proliferation and survival . Institute of Science and Technology Austria."},"date_created":"2018-12-11T11:46:22Z","related_material":{"record":[{"id":"1678","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"2084","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"1441"},{"status":"public","id":"1028","relation":"part_of_dissertation"}]},"department":[{"_id":"HaJa"}],"type":"dissertation","article_processing_charge":"No","publist_id":"7405","supervisor":[{"full_name":"Janovjak, Harald L","last_name":"Janovjak","orcid":"0000-0002-8023-9315","first_name":"Harald L","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87"}],"language":[{"iso":"eng"}],"has_accepted_license":"1","day":"08","pubrep_id":"913","publication_identifier":{"issn":["2663-337X"]},"_id":"418","file":[{"checksum":"697fa72ca36fb1b8ceabc133d58a73e5","file_size":7012495,"file_id":"6222","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2019-04-05T09:28:03Z","date_updated":"2020-07-14T12:46:24Z","access_level":"closed","creator":"dernst","relation":"source_file","file_name":"2018_THESIS_Gschaider-Reichhart_source.docx"},{"relation":"main_file","creator":"dernst","file_name":"2018_THESIS_Gschaider-Reichhart.pdf","access_level":"open_access","date_updated":"2020-07-14T12:46:24Z","content_type":"application/pdf","date_created":"2019-04-05T09:28:03Z","file_size":6355280,"file_id":"6223","checksum":"58d7d1e9e58aeb7f061ab686b1d8a48c"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_913"},{"file_date_updated":"2020-07-14T12:44:57Z","date_updated":"2026-08-12T13:58:56Z","status":"public","oa":1,"title":"Dyson equation and eigenvalue statistics of random matrices","month":"07","author":[{"id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes","last_name":"Alt","full_name":"Alt, Johannes"}],"year":"2018","degree_awarded":"PhD","abstract":[{"text":"The eigenvalue density of many large random matrices is well approximated by a deterministic measure, the self-consistent density of states. In the present work, we show this behaviour for several classes of random matrices. In fact, we establish that, in each of these classes, the self-consistent density of states approximates the eigenvalue density of the random matrix on all scales slightly above the typical eigenvalue spacing. For large classes of random matrices, the self-consistent density of states exhibits several universal features. We prove that, under suitable assumptions, random Gram matrices and Hermitian random matrices with decaying correlations have a 1/3-Hölder continuous self-consistent density of states ρ on R, which is analytic, where it is positive, and has either a square root edge or a cubic root cusp, where it vanishes. We, thus, extend the validity of the corresponding result for Wigner-type matrices from [4, 5, 7]. We show that ρ is determined as the inverse Stieltjes transform of the normalized trace of the unique solution m(z) to the Dyson equation −m(z) −1 = z − a + S[m(z)] on C N×N with the constraint Im m(z) ≥ 0. Here, z lies in the complex upper half-plane, a is a self-adjoint element of C N×N and S is a positivity-preserving operator on C N×N encoding the first two moments of the random matrix. In order to analyze a possible limit of ρ for N → ∞ and address some applications in free probability theory, we also consider the Dyson equation on infinite dimensional von Neumann algebras. We present two applications to random matrices. We first establish that, under certain assumptions, large random matrices with independent entries have a rotationally symmetric self-consistent density of states which is supported on a centered disk in C. Moreover, it is infinitely often differentiable apart from a jump on the boundary of this disk. Second, we show edge universality at all regular (not necessarily extreme) spectral edges for Hermitian random matrices with decaying correlations.","lang":"eng"}],"oa_version":"Published Version","ddc":["515","519"],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"338804"}],"publisher":"Institute of Science and Technology Austria","doi":"10.15479/AT:ISTA:TH_1040","alternative_title":["ISTA Thesis"],"publication_status":"published","date_published":"2018-07-12T00:00:00Z","fulldoi":"https://doi.org/10.15479/AT:ISTA:TH_1040","file":[{"content_type":"application/pdf","date_created":"2019-04-08T13:55:20Z","file_id":"6241","file_size":5801709,"checksum":"d4dad55a7513f345706aaaba90cb1bb8","file_name":"2018_thesis_Alt.pdf","relation":"main_file","creator":"dernst","access_level":"open_access","date_updated":"2020-07-14T12:44:57Z"},{"file_size":3802059,"file_id":"6242","date_created":"2019-04-08T13:55:20Z","content_type":"application/zip","checksum":"d73fcf46300dce74c403f2b491148ab4","access_level":"closed","creator":"dernst","relation":"source_file","file_name":"2018_thesis_Alt_source.zip","date_updated":"2020-07-14T12:44:57Z"}],"publication_identifier":{"issn":["2663-337X"]},"_id":"149","has_accepted_license":"1","day":"12","pubrep_id":"1040","publist_id":"7772","supervisor":[{"full_name":"Erdös, László","last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László"}],"language":[{"iso":"eng"}],"department":[{"_id":"LaEr"}],"article_processing_charge":"No","type":"dissertation","related_material":{"record":[{"status":"public","id":"6184","relation":"part_of_dissertation"},{"id":"6183","relation":"part_of_dissertation","status":"public"},{"id":"1010","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"550","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"6240","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"566"},{"status":"public","relation":"part_of_dissertation","id":"1677"}]},"ec_funded":1,"citation":{"short":"J. Alt, Dyson Equation and Eigenvalue Statistics of Random Matrices, Institute of Science and Technology Austria, 2018.","ieee":"J. Alt, “Dyson equation and eigenvalue statistics of random matrices,” Institute of Science and Technology Austria, 2018.","ista":"Alt J. 2018. Dyson equation and eigenvalue statistics of random matrices. Institute of Science and Technology Austria.","ama":"Alt J. Dyson equation and eigenvalue statistics of random matrices. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">10.15479/AT:ISTA:TH_1040</a>","chicago":"Alt, Johannes. “Dyson Equation and Eigenvalue Statistics of Random Matrices.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">https://doi.org/10.15479/AT:ISTA:TH_1040</a>.","apa":"Alt, J. (2018). <i>Dyson equation and eigenvalue statistics of random matrices</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">https://doi.org/10.15479/AT:ISTA:TH_1040</a>","mla":"Alt, Johannes. <i>Dyson Equation and Eigenvalue Statistics of Random Matrices</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1040\">10.15479/AT:ISTA:TH_1040</a>."},"date_created":"2018-12-11T11:44:53Z","corr_author":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"OA_place":"publisher","page":"456"},{"publication":"Journal of the Royal Society Interface","year":"2018","isi":1,"abstract":[{"lang":"eng","text":"We consider a class of students learning a language from a teacher. The situation can be interpreted as a group of child learners receiving input from the linguistic environment. The teacher provides sample sentences. The students try to learn the grammar from the teacher. In addition to just listening to the teacher, the students can also communicate with each other. The students hold hypotheses about the grammar and change them if they receive counter evidence. The process stops when all students have converged to the correct grammar. We study how the time to convergence depends on the structure of the classroom by introducing and evaluating various complexity measures. We find that structured communication between students, although potentially introducing confusion, can greatly reduce some of the complexity measures. Our theory can also be interpreted as applying to the scientific process, where nature is the teacher and the scientists are the students."}],"oa_version":"Submitted Version","ddc":["000"],"article_type":"original","file_date_updated":"2020-07-14T12:45:22Z","date_updated":"2026-08-12T14:08:29Z","status":"public","oa":1,"month":"03","title":"Language acquisition with communication between learners","scopus_import":"1","issue":"140","author":[{"first_name":"Rasmus","id":"3B699956-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4783-0389","full_name":"Ibsen-Jensen, Rasmus","last_name":"Ibsen-Jensen"},{"full_name":"Tkadlec, Josef","last_name":"Tkadlec","first_name":"Josef","id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1097-9684"},{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu"},{"full_name":"Nowak, Martin","last_name":"Nowak","first_name":"Martin"}],"publication_status":"published","intvolume":"        15","date_published":"2018-03-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications"},{"name":"Modern Graph Algorithmic Techniques in Formal Verification","grant_number":"P 23499-N23","call_identifier":"FWF","_id":"2584A770-B435-11E9-9278-68D0E5697425"},{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425"}],"publisher":"Royal Society","doi":"10.1098/rsif.2018.0073","article_number":"20180073","publication_identifier":{"eissn":["1742-5662"]},"_id":"198","has_accepted_license":"1","day":"01","quality_controlled":"1","publist_id":"7715","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1098/rsif.2018.0073","pmid":1,"file":[{"date_created":"2019-02-12T07:54:37Z","content_type":"application/pdf","file_size":219837,"file_id":"5955","checksum":"444e1a9d98eb0e780671be82b13025f3","relation":"main_file","creator":"dernst","file_name":"2018_RS_IbsenJensen.pdf","access_level":"open_access","date_updated":"2020-07-14T12:45:22Z"}],"external_id":{"isi":["000428576200023"],"pmid":["29593089"]},"citation":{"ieee":"R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, and M. Nowak, “Language acquisition with communication between learners,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 140. Royal Society, 2018.","short":"R. Ibsen-Jensen, J. Tkadlec, K. Chatterjee, M. Nowak, Journal of the Royal Society Interface 15 (2018).","ista":"Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. 2018. Language acquisition with communication between learners. Journal of the Royal Society Interface. 15(140), 20180073.","mla":"Ibsen-Jensen, Rasmus, et al. “Language Acquisition with Communication between Learners.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 140, 20180073, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0073\">10.1098/rsif.2018.0073</a>.","ama":"Ibsen-Jensen R, Tkadlec J, Chatterjee K, Nowak M. Language acquisition with communication between learners. <i>Journal of the Royal Society Interface</i>. 2018;15(140). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0073\">10.1098/rsif.2018.0073</a>","apa":"Ibsen-Jensen, R., Tkadlec, J., Chatterjee, K., &#38; Nowak, M. (2018). Language acquisition with communication between learners. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0073\">https://doi.org/10.1098/rsif.2018.0073</a>","chicago":"Ibsen-Jensen, Rasmus, Josef Tkadlec, Krishnendu Chatterjee, and Martin Nowak. “Language Acquisition with Communication between Learners.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0073\">https://doi.org/10.1098/rsif.2018.0073</a>."},"date_created":"2018-12-11T11:45:09Z","volume":15,"department":[{"_id":"KrCh"}],"type":"journal_article","article_processing_charge":"No","related_material":{"link":[{"relation":"supplementary_material","url":"https://dx.doi.org/10.6084/m9.figshare.c.4028971"}],"record":[{"id":"9814","relation":"research_data","status":"public"}]},"ec_funded":1},{"date_published":"2018-09-04T00:00:00Z","publication_status":"published","alternative_title":["ISTA Thesis"],"doi":"10.15479/AT:ISTA:th_1043","publisher":"Institute of Science and Technology Austria","project":[{"grant_number":"P27533_N27","call_identifier":"FWF","_id":"25C878CE-B435-11E9-9278-68D0E5697425","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","ddc":["515","530","519"],"oa_version":"Published Version","abstract":[{"text":"In this thesis we will discuss systems of point interacting fermions, their stability and other spectral properties. Whereas for bosons a point interacting system is always unstable this ques- tion is more subtle for a gas of two species of fermions. In particular the answer depends on the mass ratio between these two species. Most of this work will be focused on the N + M model which consists of two species of fermions with N, M particles respectively which interact via point interactions. We will introduce this model using a formal limit and discuss the N + 1 system in more detail. In particular, we will show that for mass ratios above a critical one, which does not depend on the particle number, the N + 1 system is stable. In the context of this model we will prove rigorous versions of Tan relations which relate various quantities of the point-interacting model. By restricting the N + 1 system to a box we define a finite density model with point in- teractions. In the context of this system we will discuss the energy change when introducing a point-interacting impurity into a system of non-interacting fermions. We will see that this change in energy is bounded independently of the particle number and in particular the bound only depends on the density and the scattering length. As another special case of the N + M model we will show stability of the 2 + 2 model for mass ratios in an interval around one. Further we will investigate a different model of point interactions which was discussed before in the literature and which is, contrary to the N + M model, not given by a limiting procedure but is based on a Dirichlet form. We will show that this system behaves trivially in the thermodynamic limit, i.e. the free energy per particle is the same as the one of the non-interacting system.","lang":"eng"}],"degree_awarded":"PhD","year":"2018","author":[{"id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas","last_name":"Moser","full_name":"Moser, Thomas"}],"title":"Point interactions in systems of fermions","month":"09","oa":1,"status":"public","date_updated":"2026-08-12T14:12:55Z","file_date_updated":"2020-07-14T12:46:37Z","page":"115","OA_place":"publisher","corr_author":"1","date_created":"2018-12-11T11:44:22Z","citation":{"ama":"Moser T. Point interactions in systems of fermions. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>","chicago":"Moser, Thomas. “Point Interactions in Systems of Fermions.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>.","apa":"Moser, T. (2018). <i>Point interactions in systems of fermions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>","mla":"Moser, Thomas. <i>Point Interactions in Systems of Fermions</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>.","short":"T. Moser, Point Interactions in Systems of Fermions, Institute of Science and Technology Austria, 2018.","ieee":"T. Moser, “Point interactions in systems of fermions,” Institute of Science and Technology Austria, 2018.","ista":"Moser T. 2018. Point interactions in systems of fermions. Institute of Science and Technology Austria."},"related_material":{"record":[{"status":"public","id":"5856","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"741"},{"relation":"part_of_dissertation","id":"1198","status":"public"},{"status":"public","id":"154","relation":"part_of_dissertation"}]},"article_processing_charge":"No","type":"dissertation","department":[{"_id":"RoSe"}],"supervisor":[{"orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","full_name":"Seiringer, Robert","last_name":"Seiringer"}],"language":[{"iso":"eng"}],"publist_id":"8002","has_accepted_license":"1","day":"04","pubrep_id":"1043","_id":"52","publication_identifier":{"issn":["2663-337X"]},"file":[{"relation":"main_file","creator":"dernst","file_name":"2018_Thesis_Moser.pdf","access_level":"open_access","date_updated":"2020-07-14T12:46:37Z","content_type":"application/pdf","date_created":"2019-04-09T07:45:38Z","file_size":851164,"file_id":"6256","checksum":"fbd8c747d148b468a21213b7cf175225"},{"content_type":"application/zip","date_created":"2019-04-09T07:45:38Z","file_size":1531516,"file_id":"6257","checksum":"c28e16ecfc1126d3ce324ec96493c01e","relation":"source_file","creator":"dernst","file_name":"2018_Thesis_Moser_Source.zip","access_level":"closed","date_updated":"2020-07-14T12:46:37Z"}],"fulldoi":"https://doi.org/10.15479/AT:ISTA:th_1043"},{"publication":"Mathematical Physics, Analysis and Geometry","year":"2018","isi":1,"abstract":[{"lang":"eng","text":"We give a lower bound on the ground state energy of a system of two fermions of one species interacting with two fermions of another species via point interactions. We show that there is a critical mass ratio m2 ≈ 0.58 such that the system is stable, i.e., the energy is bounded from below, for m∈[m2,m2−1]. So far it was not known whether this 2 + 2 system exhibits a stable region at all or whether the formation of four-body bound states causes an unbounded spectrum for all mass ratios, similar to the Thomas effect. Our result gives further evidence for the stability of the more general N + M system."}],"oa_version":"Published Version","ddc":["530"],"article_type":"original","file_date_updated":"2020-07-14T12:45:01Z","date_updated":"2026-08-12T14:12:56Z","oa":1,"status":"public","month":"09","title":"Stability of the 2+2 fermionic system with point interactions","scopus_import":"1","author":[{"last_name":"Moser","full_name":"Moser, Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas"},{"last_name":"Seiringer","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521"}],"issue":"3","publication_status":"published","intvolume":"        21","date_published":"2018-09-01T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"Analysis of quantum many-body systems","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"694227"},{"call_identifier":"FWF","grant_number":"P27533_N27","_id":"25C878CE-B435-11E9-9278-68D0E5697425","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems"},{"call_identifier":"FWF","_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1","name":"FWF Open Access Fund"}],"publisher":"Springer","doi":"10.1007/s11040-018-9275-3","article_number":"19","publication_identifier":{"eissn":["1572-9656"],"issn":["1385-0172"]},"_id":"154","has_accepted_license":"1","day":"01","publist_id":"7767","quality_controlled":"1","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1007/s11040-018-9275-3","file":[{"date_updated":"2020-07-14T12:45:01Z","relation":"main_file","creator":"dernst","file_name":"2018_MathPhysics_Moser.pdf","access_level":"open_access","checksum":"411c4db5700d7297c9cd8ebc5dd29091","date_created":"2018-12-17T16:49:02Z","content_type":"application/pdf","file_size":496973,"file_id":"5729"}],"external_id":{"isi":["000439639700001"]},"citation":{"apa":"Moser, T., &#38; Seiringer, R. (2018). Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics, Analysis and Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>","chicago":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s11040-018-9275-3\">https://doi.org/10.1007/s11040-018-9275-3</a>.","ama":"Moser T, Seiringer R. Stability of the 2+2 fermionic system with point interactions. <i>Mathematical Physics, Analysis and Geometry</i>. 2018;21(3). doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>","mla":"Moser, Thomas, and Robert Seiringer. “Stability of the 2+2 Fermionic System with Point Interactions.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 21, no. 3, 19, Springer, 2018, doi:<a href=\"https://doi.org/10.1007/s11040-018-9275-3\">10.1007/s11040-018-9275-3</a>.","short":"T. Moser, R. Seiringer, Mathematical Physics, Analysis and Geometry 21 (2018).","ieee":"T. Moser and R. Seiringer, “Stability of the 2+2 fermionic system with point interactions,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 21, no. 3. Springer, 2018.","ista":"Moser T, Seiringer R. 2018. Stability of the 2+2 fermionic system with point interactions. Mathematical Physics, Analysis and Geometry. 21(3), 19."},"date_created":"2018-12-11T11:44:55Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":21,"department":[{"_id":"RoSe"}],"article_processing_charge":"No","type":"journal_article","related_material":{"record":[{"id":"52","relation":"dissertation_contains","status":"public"}]},"acknowledgement":"Open access funding provided by Austrian Science Fund (FWF).","ec_funded":1},{"fulldoi":"https://doi.org/10.3791/58585","date_updated":"2026-08-12T14:10:17Z","status":"public","scopus_import":"1","title":"A micro-CT-based method for characterising lesions and locating electrodes in small animal brains","month":"11","external_id":{"isi":["000456469400103"]},"author":[{"first_name":"Javier","full_name":"Masís, Javier","last_name":"Masís"},{"full_name":"Mankus, David","last_name":"Mankus","first_name":"David"},{"first_name":"Steffen","last_name":"Wolff","full_name":"Wolff, Steffen"},{"last_name":"Guitchounts","full_name":"Guitchounts, Grigori","first_name":"Grigori"},{"orcid":"0000-0002-3937-1330","first_name":"Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","last_name":"Jösch","full_name":"Jösch, Maximilian A"},{"first_name":"David","full_name":"Cox, David","last_name":"Cox"}],"publication":"Journal of Visualized Experiments","_id":"6","year":"2018","isi":1,"day":"08","abstract":[{"text":"Lesion and electrode location verification are traditionally done via histological examination of stained brain slices, a time-consuming procedure that requires manual estimation. Here, we describe a simple, straightforward method for quantifying lesions and locating electrodes in the brain that is less laborious and yields more detailed results. Whole brains are stained with osmium tetroxide, embedded in resin, and imaged with a micro-CT scanner. The scans result in 3D digital volumes of the brains with resolutions and virtual section thicknesses dependent on the sample size (12-15 and 5-6 µm per voxel for rat and zebra finch brains, respectively). Surface and deep lesions can be characterized, and single tetrodes, tetrode arrays, electrolytic lesions, and silicon probes can also be localized. Free and proprietary software allows experimenters to examine the sample volume from any plane and segment the volume manually or automatically. Because this method generates whole brain volume, lesions and electrodes can be quantified to a much higher degree than in current methods, which will help standardize comparisons within and across studies.","lang":"eng"}],"oa_version":"None","quality_controlled":"1","publist_id":"8050","language":[{"iso":"eng"}],"department":[{"_id":"MaJö"}],"type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","publisher":"MyJove Corporation","doi":"10.3791/58585","citation":{"ista":"Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. 2018. A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. Journal of Visualized Experiments. 141.","ieee":"J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M. A. Jösch, and D. Cox, “A micro-CT-based method for characterising lesions and locating electrodes in small animal brains,” <i>Journal of Visualized Experiments</i>, vol. 141. MyJove Corporation, 2018.","short":"J. Masís, D. Mankus, S. Wolff, G. Guitchounts, M.A. Jösch, D. Cox, Journal of Visualized Experiments 141 (2018).","mla":"Masís, Javier, et al. “A Micro-CT-Based Method for Characterising Lesions and Locating Electrodes in Small Animal Brains.” <i>Journal of Visualized Experiments</i>, vol. 141, MyJove Corporation, 2018, doi:<a href=\"https://doi.org/10.3791/58585\">10.3791/58585</a>.","apa":"Masís, J., Mankus, D., Wolff, S., Guitchounts, G., Jösch, M. A., &#38; Cox, D. (2018). A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. <i>Journal of Visualized Experiments</i>. MyJove Corporation. <a href=\"https://doi.org/10.3791/58585\">https://doi.org/10.3791/58585</a>","chicago":"Masís, Javier, David Mankus, Steffen Wolff, Grigori Guitchounts, Maximilian A Jösch, and David Cox. “A Micro-CT-Based Method for Characterising Lesions and Locating Electrodes in Small Animal Brains.” <i>Journal of Visualized Experiments</i>. MyJove Corporation, 2018. <a href=\"https://doi.org/10.3791/58585\">https://doi.org/10.3791/58585</a>.","ama":"Masís J, Mankus D, Wolff S, Guitchounts G, Jösch MA, Cox D. A micro-CT-based method for characterising lesions and locating electrodes in small animal brains. <i>Journal of Visualized Experiments</i>. 2018;141. doi:<a href=\"https://doi.org/10.3791/58585\">10.3791/58585</a>"},"date_created":"2018-12-11T11:44:07Z","intvolume":"       141","publication_status":"published","volume":141,"date_published":"2018-11-08T00:00:00Z"},{"oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"We developed a method to calculate two-photon processes in quantum mechanics that replaces the infinite summation over the intermediate states by a perturbation expansion. This latter consists of a series of commutators that involve position, momentum, and Hamiltonian quantum operators. We analyzed several single- and many-particle cases for which a closed-form solution to the perturbation expansion exists, as well as more complicated cases for which a solution is found by convergence. Throughout the article, Rayleigh and Raman scattering are taken as examples of two-photon processes. The present method provides a clear distinction between the Thomson scattering, regarded as classical scattering, and quantum contributions. Such a distinction lets us derive general results concerning light scattering. Finally, possible extensions to the developed formalism are discussed."}],"isi":1,"year":"2018","publication":"Physical Review A","author":[{"full_name":"Fratini, Filippo","last_name":"Fratini","first_name":"Filippo"},{"full_name":"Safari, Laleh","last_name":"Safari","first_name":"Laleh","id":"3C325E5E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Amaro","full_name":"Amaro, Pedro","first_name":"Pedro"},{"first_name":"José","full_name":"Santos, José","last_name":"Santos"}],"issue":"4","scopus_import":"1","title":"Two-photon processes based on quantum commutators","month":"04","status":"public","oa":1,"date_updated":"2026-08-12T14:22:13Z","date_published":"2018-04-18T00:00:00Z","intvolume":"        97","publication_status":"published","main_file_link":[{"url":"https://arxiv.org/abs/1801.06892","open_access":"1"}],"arxiv":1,"doi":"10.1103/PhysRevA.97.043842","publisher":"American Physical Society","project":[{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"quality_controlled":"1","publist_id":"7587","day":"18","_id":"294","external_id":{"isi":["000430296800008"],"arxiv":["1801.06892"]},"fulldoi":"https://doi.org/10.1103/PhysRevA.97.043842","volume":97,"date_created":"2018-12-11T11:45:40Z","citation":{"apa":"Fratini, F., Safari, L., Amaro, P., &#38; Santos, J. (2018). Two-photon processes based on quantum commutators. <i>Physical Review A</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">https://doi.org/10.1103/PhysRevA.97.043842</a>","ama":"Fratini F, Safari L, Amaro P, Santos J. Two-photon processes based on quantum commutators. <i>Physical Review A</i>. 2018;97(4). doi:<a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">10.1103/PhysRevA.97.043842</a>","chicago":"Fratini, Filippo, Laleh Safari, Pedro Amaro, and José Santos. “Two-Photon Processes Based on Quantum Commutators.” <i>Physical Review A</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">https://doi.org/10.1103/PhysRevA.97.043842</a>.","mla":"Fratini, Filippo, et al. “Two-Photon Processes Based on Quantum Commutators.” <i>Physical Review A</i>, vol. 97, no. 4, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/PhysRevA.97.043842\">10.1103/PhysRevA.97.043842</a>.","ista":"Fratini F, Safari L, Amaro P, Santos J. 2018. Two-photon processes based on quantum commutators. Physical Review A. 97(4).","short":"F. Fratini, L. Safari, P. Amaro, J. Santos, Physical Review A 97 (2018).","ieee":"F. Fratini, L. Safari, P. Amaro, and J. Santos, “Two-photon processes based on quantum commutators,” <i>Physical Review A</i>, vol. 97, no. 4. American Physical Society, 2018."},"ec_funded":1,"type":"journal_article","article_processing_charge":"No","department":[{"_id":"MiLe"}]},{"quality_controlled":"1","language":[{"iso":"eng"}],"_id":"195","day":"15","external_id":{"arxiv":["1712.00308"],"isi":["000436939100007"]},"fulldoi":"https://doi.org/10.1103/PhysRevB.98.045402","volume":98,"citation":{"ista":"Yakaboylu E, Lemeshko M. 2018. Anyonic statistics of quantum impurities in two dimensions. Physical Review B. 98(4), 045402.","ieee":"E. Yakaboylu and M. Lemeshko, “Anyonic statistics of quantum impurities in two dimensions,” <i>Physical Review B</i>, vol. 98, no. 4. American Physical Society, 2018.","short":"E. Yakaboylu, M. Lemeshko, Physical Review B 98 (2018).","mla":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anyonic Statistics of Quantum Impurities in Two Dimensions.” <i>Physical Review B</i>, vol. 98, no. 4, 045402, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">10.1103/PhysRevB.98.045402</a>.","chicago":"Yakaboylu, Enderalp, and Mikhail Lemeshko. “Anyonic Statistics of Quantum Impurities in Two Dimensions.” <i>Physical Review B</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">https://doi.org/10.1103/PhysRevB.98.045402</a>.","ama":"Yakaboylu E, Lemeshko M. Anyonic statistics of quantum impurities in two dimensions. <i>Physical Review B</i>. 2018;98(4). doi:<a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">10.1103/PhysRevB.98.045402</a>","apa":"Yakaboylu, E., &#38; Lemeshko, M. (2018). Anyonic statistics of quantum impurities in two dimensions. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.98.045402\">https://doi.org/10.1103/PhysRevB.98.045402</a>"},"date_created":"2018-12-11T11:45:08Z","corr_author":"1","ec_funded":1,"department":[{"_id":"MiLe"}],"type":"journal_article","article_processing_charge":"No","abstract":[{"lang":"eng","text":"We demonstrate that identical impurities immersed in a two-dimensional many-particle bath can be viewed as flux-tube-charged-particle composites described by fractional statistics. In particular, we find that the bath manifests itself as an external magnetic flux tube with respect to the impurities, and hence the time-reversal symmetry is broken for the effective Hamiltonian describing the impurities. The emerging flux tube acts as a statistical gauge field after a certain critical coupling. This critical coupling corresponds to the intersection point between the quasiparticle state and the phonon wing, where the angular momentum is transferred from the impurity to the bath. This amounts to a novel configuration with emerging anyons. The proposed setup paves the way to realizing anyons using electrons interacting with superfluid helium or lattice phonons, as well as using atomic impurities in ultracold gases."}],"oa_version":"Submitted Version","publication":"Physical Review B","year":"2018","isi":1,"date_updated":"2026-08-12T14:24:49Z","oa":1,"status":"public","title":"Anyonic statistics of quantum impurities in two dimensions","month":"07","scopus_import":"1","author":[{"id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","first_name":"Enderalp","orcid":"0000-0001-5973-0874","full_name":"Yakaboylu, Enderalp","last_name":"Yakaboylu"},{"full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail"}],"issue":"4","publication_status":"published","intvolume":"        98","date_published":"2018-07-15T00:00:00Z","main_file_link":[{"url":"https://arxiv.org/abs/1712.00308","open_access":"1"}],"doi":"10.1103/PhysRevB.98.045402","article_number":"045402","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"},{"name":"Quantum rotations in the presence of a many-body environment","_id":"26031614-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P29902"}],"publisher":"American Physical Society"},{"article_processing_charge":"No","type":"journal_article","department":[{"_id":"LaEr"}],"ec_funded":1,"date_created":"2019-02-13T10:40:54Z","citation":{"ista":"Erdös L, Mühlbacher P. 2018. Bounds on the norm of Wigner-type random matrices. Random Matrices: Theory and Applications., 1950009.","short":"L. Erdös, P. Mühlbacher, Random Matrices: Theory and Applications (2018).","ieee":"L. Erdös and P. Mühlbacher, “Bounds on the norm of Wigner-type random matrices,” <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing, 2018.","chicago":"Erdös, László, and Peter Mühlbacher. “Bounds on the Norm of Wigner-Type Random Matrices.” <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing, 2018. <a href=\"https://doi.org/10.1142/s2010326319500096\">https://doi.org/10.1142/s2010326319500096</a>.","apa":"Erdös, L., &#38; Mühlbacher, P. (2018). Bounds on the norm of Wigner-type random matrices. <i>Random Matrices: Theory and Applications</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/s2010326319500096\">https://doi.org/10.1142/s2010326319500096</a>","ama":"Erdös L, Mühlbacher P. Bounds on the norm of Wigner-type random matrices. <i>Random Matrices: Theory and Applications</i>. 2018. doi:<a href=\"https://doi.org/10.1142/s2010326319500096\">10.1142/s2010326319500096</a>","mla":"Erdös, László, and Peter Mühlbacher. “Bounds on the Norm of Wigner-Type Random Matrices.” <i>Random Matrices: Theory and Applications</i>, 1950009, World Scientific Publishing, 2018, doi:<a href=\"https://doi.org/10.1142/s2010326319500096\">10.1142/s2010326319500096</a>."},"fulldoi":"https://doi.org/10.1142/s2010326319500096","external_id":{"arxiv":["1802.05175"],"isi":["000477677200002"]},"_id":"5971","publication_identifier":{"issn":["2010-3263"],"eissn":["2010-3271"]},"day":"26","language":[{"iso":"eng"}],"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"World Scientific Publishing","project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"}],"doi":"10.1142/s2010326319500096","arxiv":1,"article_number":"1950009","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1802.05175"}],"publication_status":"published","date_published":"2018-09-26T00:00:00Z","status":"public","oa":1,"date_updated":"2026-08-12T14:33:01Z","author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös","full_name":"Erdös, László"},{"first_name":"Peter","last_name":"Mühlbacher","full_name":"Mühlbacher, Peter"}],"title":"Bounds on the norm of Wigner-type random matrices","month":"09","scopus_import":"1","year":"2018","publication":"Random Matrices: Theory and Applications","isi":1,"oa_version":"Preprint","abstract":[{"text":"We consider a Wigner-type ensemble, i.e. large hermitian N×N random matrices H=H∗ with centered independent entries and with a general matrix of variances Sxy=𝔼∣∣Hxy∣∣2. The norm of H is asymptotically given by the maximum of the support of the self-consistent density of states. We establish a bound on this maximum in terms of norms of powers of S that substantially improves the earlier bound 2∥S∥1/2∞ given in [O. Ajanki, L. Erdős and T. Krüger, Universality for general Wigner-type matrices, Prob. Theor. Rel. Fields169 (2017) 667–727]. The key element of the proof is an effective Markov chain approximation for the contributions of the weighted Dyck paths appearing in the iterative solution of the corresponding Dyson equation.","lang":"eng"}]},{"department":[{"_id":"VlKo"}],"article_processing_charge":"No","type":"conference","page":"6581-6588","citation":{"ama":"Haller S, Swoboda P, Savchynskyy B. Exact MAP-inference by confining combinatorial search with LP relaxation. In: <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>. AAAI Press; 2018:6581-6588. doi:<a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">10.1609/aaai.v32i1.12202</a>","chicago":"Haller, Stefan, Paul Swoboda, and Bogdan Savchynskyy. “Exact MAP-Inference by Confining Combinatorial Search with LP Relaxation.” In <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, 6581–88. AAAI Press, 2018. <a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">https://doi.org/10.1609/aaai.v32i1.12202</a>.","apa":"Haller, S., Swoboda, P., &#38; Savchynskyy, B. (2018). Exact MAP-inference by confining combinatorial search with LP relaxation. In <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i> (pp. 6581–6588). New Orleans, LU, United States: AAAI Press. <a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">https://doi.org/10.1609/aaai.v32i1.12202</a>","mla":"Haller, Stefan, et al. “Exact MAP-Inference by Confining Combinatorial Search with LP Relaxation.” <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, AAAI Press, 2018, pp. 6581–88, doi:<a href=\"https://doi.org/10.1609/aaai.v32i1.12202\">10.1609/aaai.v32i1.12202</a>.","ista":"Haller S, Swoboda P, Savchynskyy B. 2018. Exact MAP-inference by confining combinatorial search with LP relaxation. Proceedings of the 32st AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence, 6581–6588.","short":"S. Haller, P. Swoboda, B. Savchynskyy, in:, Proceedings of the 32st AAAI Conference on Artificial Intelligence, AAAI Press, 2018, pp. 6581–6588.","ieee":"S. Haller, P. Swoboda, and B. Savchynskyy, “Exact MAP-inference by confining combinatorial search with LP relaxation,” in <i>Proceedings of the 32st AAAI Conference on Artificial Intelligence</i>, New Orleans, LU, United States, 2018, pp. 6581–6588."},"date_created":"2019-02-13T13:32:48Z","external_id":{"arxiv":["2004.06370"],"isi":["000485488906082"]},"conference":{"name":"AAAI: Conference on Artificial Intelligence","start_date":"2018-02-02","end_date":"2018-02-07","location":"New Orleans, LU, United States"},"fulldoi":"https://doi.org/10.1609/aaai.v32i1.12202","quality_controlled":"1","language":[{"iso":"eng"}],"day":"01","_id":"5978","arxiv":1,"doi":"10.1609/aaai.v32i1.12202","publisher":"AAAI Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2018-02-01T00:00:00Z","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2004.06370"}],"scopus_import":"1","month":"02","title":"Exact MAP-inference by confining combinatorial search with LP relaxation","author":[{"first_name":"Stefan","last_name":"Haller","full_name":"Haller, Stefan"},{"last_name":"Swoboda","full_name":"Swoboda, Paul","id":"446560C6-F248-11E8-B48F-1D18A9856A87","first_name":"Paul"},{"last_name":"Savchynskyy","full_name":"Savchynskyy, Bogdan","first_name":"Bogdan"}],"date_updated":"2026-08-19T09:30:58Z","oa":1,"status":"public","abstract":[{"lang":"eng","text":"We consider the MAP-inference problem for graphical models,which is a valued constraint satisfaction problem defined onreal numbers with a natural summation operation. We proposea family of relaxations (different from the famous Sherali-Adams hierarchy), which naturally define lower bounds for itsoptimum. This family always contains a tight relaxation andwe give an algorithm able to find it and therefore, solve theinitial non-relaxed NP-hard problem.The relaxations we consider decompose the original probleminto two non-overlapping parts: an easy LP-tight part and adifficult one. For the latter part a combinatorial solver must beused. As we show in our experiments, in a number of applica-tions the second, difficult part constitutes only a small fractionof the whole problem. This property allows to significantlyreduce the computational time of the combinatorial solver andtherefore solve problems which were out of reach before."}],"oa_version":"Preprint","isi":1,"publication":"Proceedings of the 32st AAAI Conference on Artificial Intelligence","year":"2018"},{"_id":"3","day":"19","pubrep_id":"1071","has_accepted_license":"1","publist_id":"8054","quality_controlled":"1","language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1038/s41593-018-0266-2","file":[{"access_level":"open_access","creator":"dernst","relation":"main_file","file_name":"2017_NatureNeuroscience_Deliu.pdf","date_updated":"2020-07-14T12:45:58Z","file_size":8167169,"file_id":"6255","date_created":"2019-04-09T07:41:57Z","content_type":"application/pdf","checksum":"60abd0f05b7cdc08a6b0ec460884084f"}],"external_id":{"isi":["000451324700010"]},"citation":{"short":"E. Deliu, N. Arecco, J. Morandell, C. Dotter, X. Contreras, C. Girardot, E. Käsper, A. Kozlova, K. Kishi, I. Chiaradia, K. Noh, G. Novarino, Nature Neuroscience 21 (2018) 1717–1727.","ieee":"E. Deliu <i>et al.</i>, “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition,” <i>Nature Neuroscience</i>, vol. 21, no. 12. Nature Publishing Group, pp. 1717–1727, 2018.","ista":"Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, Käsper E, Kozlova A, Kishi K, Chiaradia I, Noh K, Novarino G. 2018. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nature Neuroscience. 21(12), 1717–1727.","chicago":"Deliu, Elena, Niccoló Arecco, Jasmin Morandell, Christoph Dotter, Ximena Contreras, Charles Girardot, Eva Käsper, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>.","ama":"Deliu E, Arecco N, Morandell J, et al. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. 2018;21(12):1717-1727. doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>","apa":"Deliu, E., Arecco, N., Morandell, J., Dotter, C., Contreras, X., Girardot, C., … Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41593-018-0266-2\">https://doi.org/10.1038/s41593-018-0266-2</a>","mla":"Deliu, Elena, et al. “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>, vol. 21, no. 12, Nature Publishing Group, 2018, pp. 1717–27, doi:<a href=\"https://doi.org/10.1038/s41593-018-0266-2\">10.1038/s41593-018-0266-2</a>."},"date_created":"2018-12-11T11:44:05Z","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"}],"corr_author":"1","volume":21,"page":"1717 - 1727","department":[{"_id":"GaNo"},{"_id":"EdHa"}],"article_processing_charge":"No","type":"journal_article","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/mutation-that-causes-autism-and-intellectual-disability-makes-brain-less-flexible/"}],"record":[{"relation":"popular_science","id":"6074","status":"public"},{"status":"public","id":"12364","relation":"dissertation_contains"}]},"acknowledgement":"This work was supported by the Simons Foundation Autism Research Initiative (grant 401299) to G.N. and the DFG (SPP1738 grant NO 1249) to K.-M.N.","publication":"Nature Neuroscience","year":"2018","isi":1,"abstract":[{"text":"SETD5 gene mutations have been identified as a frequent cause of idiopathic intellectual disability. Here we show that Setd5-haploinsufficient mice present developmental defects such as abnormal brain-to-body weight ratios and neural crest defect-associated phenotypes. Furthermore, Setd5-mutant mice show impairments in cognitive tasks, enhanced long-term potentiation, delayed ontogenetic profile of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are accompanied by abnormal expression of postsynaptic density proteins previously associated with cognition. Our data additionally indicate that Setd5 regulates RNA polymerase II dynamics and gene transcription via its interaction with the Hdac3 and Paf1 complexes, findings potentially explaining the gene expression defects observed in Setd5-haploinsufficient mice. Our results emphasize the decisive role of Setd5 in a biological pathway found to be disrupted in humans with intellectual disability and autism spectrum disorder.","lang":"eng"}],"oa_version":"Submitted Version","article_type":"original","ddc":["570"],"file_date_updated":"2020-07-14T12:45:58Z","date_updated":"2026-09-16T22:30:08Z","status":"public","oa":1,"month":"11","title":"Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition","scopus_import":"1","issue":"12","author":[{"orcid":"0000-0002-7370-5293","id":"37A40D7E-F248-11E8-B48F-1D18A9856A87","first_name":"Elena","last_name":"Deliu","full_name":"Deliu, Elena"},{"first_name":"Niccoló","full_name":"Arecco, Niccoló","last_name":"Arecco"},{"id":"4739D480-F248-11E8-B48F-1D18A9856A87","first_name":"Jasmin","last_name":"Morandell","full_name":"Morandell, Jasmin"},{"full_name":"Dotter, Christoph","last_name":"Dotter","id":"4C66542E-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","orcid":"0000-0002-9033-9096"},{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","first_name":"Ximena","full_name":"Contreras, Ximena","last_name":"Contreras"},{"last_name":"Girardot","full_name":"Girardot, Charles","first_name":"Charles"},{"full_name":"Käsper, Eva","last_name":"Käsper","first_name":"Eva"},{"first_name":"Alena","id":"C50A9596-02D0-11E9-976E-E38CFE5CBC1D","last_name":"Kozlova","full_name":"Kozlova, Alena"},{"full_name":"Kishi, Kasumi","last_name":"Kishi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","first_name":"Kasumi","orcid":"0000-0001-6060-4795"},{"first_name":"Ilaria","id":"B6467F20-02D0-11E9-BDA5-E960C241894A","orcid":"0000-0002-9529-4464","full_name":"Chiaradia, Ilaria","last_name":"Chiaradia"},{"full_name":"Noh, Kyung","last_name":"Noh","first_name":"Kyung"},{"full_name":"Novarino, Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","orcid":"0000-0002-7673-7178"}],"publication_status":"published","intvolume":"        21","date_published":"2018-11-19T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","project":[{"grant_number":"401299","_id":"254BA948-B435-11E9-9278-68D0E5697425","name":"Probing development and reversibility of autism spectrum disorders"}],"publisher":"Nature Publishing Group","doi":"10.1038/s41593-018-0266-2"}]