[{"doi":"10.1126/scitranslmed.aan2786","issue":"387","language":[{"iso":"eng"}],"year":"2017","month":"04","type":"journal_article","status":"public","publication_identifier":{"issn":["1946-6234"]},"volume":9,"corr_author":"1","article_number":"2786","date_published":"2017-04-26T00:00:00Z","publication":"Science Translational Medicine","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"Perinatal exposure to penicillin may result in longlasting gut and behavioral changes."}],"date_updated":"2025-07-10T11:53:44Z","author":[{"last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"}],"title":"The antisocial side of antibiotics","date_created":"2018-12-11T11:47:48Z","article_processing_charge":"No","oa_version":"None","_id":"667","day":"26","department":[{"_id":"GaNo"}],"intvolume":"         9","scopus_import":"1","publisher":"American Association for the Advancement of Science","publist_id":"7060","quality_controlled":"1","citation":{"ista":"Novarino G. 2017. The antisocial side of antibiotics. Science Translational Medicine. 9(387), 2786.","ieee":"G. Novarino, “The antisocial side of antibiotics,” <i>Science Translational Medicine</i>, vol. 9, no. 387. American Association for the Advancement of Science, 2017.","mla":"Novarino, Gaia. “The Antisocial Side of Antibiotics.” <i>Science Translational Medicine</i>, vol. 9, no. 387, 2786, American Association for the Advancement of Science, 2017, doi:<a href=\"https://doi.org/10.1126/scitranslmed.aan2786\">10.1126/scitranslmed.aan2786</a>.","short":"G. Novarino, Science Translational Medicine 9 (2017).","apa":"Novarino, G. (2017). The antisocial side of antibiotics. <i>Science Translational Medicine</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/scitranslmed.aan2786\">https://doi.org/10.1126/scitranslmed.aan2786</a>","ama":"Novarino G. The antisocial side of antibiotics. <i>Science Translational Medicine</i>. 2017;9(387). doi:<a href=\"https://doi.org/10.1126/scitranslmed.aan2786\">10.1126/scitranslmed.aan2786</a>","chicago":"Novarino, Gaia. “The Antisocial Side of Antibiotics.” <i>Science Translational Medicine</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/scitranslmed.aan2786\">https://doi.org/10.1126/scitranslmed.aan2786</a>."}},{"abstract":[{"lang":"eng","text":"Macrophage filopodia, finger-like membrane protrusions, were first implicated in phagocytosis more than 100 years ago, but little is still known about the involvement of these actin-dependent structures in particle clearance. Using spinning disk confocal microscopy to image filopodial dynamics in mouse resident Lifeact-EGFP macrophages, we show that filopodia, or filopodia-like structures, support pathogen clearance by multiple means. Filopodia supported the phagocytic uptake of bacterial (Escherichia coli) particles by (i) capturing along the filopodial shaft and surfing toward the cell body, the most common mode of capture; (ii) capturing via the tip followed by retraction; (iii) combinations of surfing and retraction; or (iv) sweeping actions. In addition, filopodia supported the uptake of zymosan (Saccharomyces cerevisiae) particles by (i) providing fixation, (ii) capturing at the tip and filopodia-guided actin anterograde flow with phagocytic cup formation, and (iii) the rapid growth of new protrusions. To explore the role of filopodia-inducing Cdc42, we generated myeloid-restricted Cdc42 knock-out mice. Cdc42-deficient macrophages exhibited rapid phagocytic cup kinetics, but reduced particle clearance, which could be explained by the marked rounded-up morphology of these cells. Macrophages lacking Myo10, thought to act downstream of Cdc42, had normal morphology, motility, and phagocytic cup formation, but displayed markedly reduced filopodia formation. In conclusion, live-cell imaging revealed multiple mechanisms involving macrophage filopodia in particle capture and engulfment. Cdc42 is not critical for filopodia or phagocytic cup formation, but plays a key role in driving macrophage lamellipodial spreading."}],"date_updated":"2025-09-11T07:03:17Z","date_created":"2018-12-11T11:47:49Z","external_id":{"isi":["000400478300035"]},"author":[{"full_name":"Horsthemke, Markus","first_name":"Markus","last_name":"Horsthemke"},{"first_name":"Anne","last_name":"Bachg","full_name":"Bachg, Anne"},{"full_name":"Groll, Katharina","last_name":"Groll","first_name":"Katharina"},{"full_name":"Moyzio, Sven","first_name":"Sven","last_name":"Moyzio"},{"last_name":"Müther","first_name":"Barbara","full_name":"Müther, Barbara"},{"full_name":"Hemkemeyer, Sandra","first_name":"Sandra","last_name":"Hemkemeyer"},{"full_name":"Wedlich Söldner, Roland","last_name":"Wedlich Söldner","first_name":"Roland"},{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"},{"full_name":"Tacke, Sebastian","last_name":"Tacke","first_name":"Sebastian"},{"last_name":"Bähler","first_name":"Martin","full_name":"Bähler, Martin"},{"first_name":"Peter","last_name":"Hanley","full_name":"Hanley, Peter"}],"title":"Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion","date_published":"2017-04-28T00:00:00Z","publication":"Journal of Biological Chemistry","file_date_updated":"2020-07-14T12:47:37Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publisher":"American Society for Biochemistry and Molecular Biology","publist_id":"7059","ddc":["570"],"citation":{"ista":"Horsthemke M, Bachg A, Groll K, Moyzio S, Müther B, Hemkemeyer S, Wedlich Söldner R, Sixt MK, Tacke S, Bähler M, Hanley P. 2017. Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. Journal of Biological Chemistry. 292(17), 7258–7273.","mla":"Horsthemke, Markus, et al. “Multiple Roles of Filopodial Dynamics in Particle Capture and Phagocytosis and Phenotypes of Cdc42 and Myo10 Deletion.” <i>Journal of Biological Chemistry</i>, vol. 292, no. 17, American Society for Biochemistry and Molecular Biology, 2017, pp. 7258–73, doi:<a href=\"https://doi.org/10.1074/jbc.M116.766923\">10.1074/jbc.M116.766923</a>.","short":"M. Horsthemke, A. Bachg, K. Groll, S. Moyzio, B. Müther, S. Hemkemeyer, R. Wedlich Söldner, M.K. Sixt, S. Tacke, M. Bähler, P. Hanley, Journal of Biological Chemistry 292 (2017) 7258–7273.","ieee":"M. Horsthemke <i>et al.</i>, “Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion,” <i>Journal of Biological Chemistry</i>, vol. 292, no. 17. American Society for Biochemistry and Molecular Biology, pp. 7258–7273, 2017.","apa":"Horsthemke, M., Bachg, A., Groll, K., Moyzio, S., Müther, B., Hemkemeyer, S., … Hanley, P. (2017). Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1074/jbc.M116.766923\">https://doi.org/10.1074/jbc.M116.766923</a>","ama":"Horsthemke M, Bachg A, Groll K, et al. Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. <i>Journal of Biological Chemistry</i>. 2017;292(17):7258-7273. doi:<a href=\"https://doi.org/10.1074/jbc.M116.766923\">10.1074/jbc.M116.766923</a>","chicago":"Horsthemke, Markus, Anne Bachg, Katharina Groll, Sven Moyzio, Barbara Müther, Sandra Hemkemeyer, Roland Wedlich Söldner, et al. “Multiple Roles of Filopodial Dynamics in Particle Capture and Phagocytosis and Phenotypes of Cdc42 and Myo10 Deletion.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 2017. <a href=\"https://doi.org/10.1074/jbc.M116.766923\">https://doi.org/10.1074/jbc.M116.766923</a>."},"quality_controlled":"1","_id":"668","article_processing_charge":"No","oa_version":"Published Version","day":"28","intvolume":"       292","department":[{"_id":"MiSi"}],"article_type":"original","scopus_import":"1","isi":1,"month":"04","doi":"10.1074/jbc.M116.766923","issue":"17","has_accepted_license":"1","page":"7258 - 7273","language":[{"iso":"eng"}],"file":[{"file_id":"6971","access_level":"open_access","creator":"dernst","date_created":"2019-10-24T15:25:42Z","relation":"main_file","content_type":"application/pdf","checksum":"d488162874326a4bb056065fa549dc4a","file_size":5647880,"file_name":"2017_JBC_Horsthemke.pdf","date_updated":"2020-07-14T12:47:37Z"}],"year":"2017","oa":1,"status":"public","publication_identifier":{"issn":["0021-9258"]},"volume":292,"type":"journal_article"},{"article_processing_charge":"No","oa_version":"Submitted Version","_id":"669","day":"01","department":[{"_id":"JiFr"}],"intvolume":"       174","article_type":"original","scopus_import":"1","publist_id":"7058","publisher":"American Society of Plant Biologists","ddc":["580"],"quality_controlled":"1","citation":{"ieee":"L. Synek <i>et al.</i>, “EXO70C2 is a key regulatory factor for optimal tip growth of pollen,” <i>Plant Physiology</i>, vol. 174, no. 1. American Society of Plant Biologists, pp. 223–240, 2017.","short":"L. Synek, N. Vukašinović, I. Kulich, M. Hála, K. Aldorfová, M. Fendrych, V. Žárský, Plant Physiology 174 (2017) 223–240.","mla":"Synek, Lukáš, et al. “EXO70C2 Is a Key Regulatory Factor for Optimal Tip Growth of Pollen.” <i>Plant Physiology</i>, vol. 174, no. 1, American Society of Plant Biologists, 2017, pp. 223–40, doi:<a href=\"https://doi.org/10.1104/pp.16.01282\">10.1104/pp.16.01282</a>.","ista":"Synek L, Vukašinović N, Kulich I, Hála M, Aldorfová K, Fendrych M, Žárský V. 2017. EXO70C2 is a key regulatory factor for optimal tip growth of pollen. Plant Physiology. 174(1), 223–240.","chicago":"Synek, Lukáš, Nemanja Vukašinović, Ivan Kulich, Michal Hála, Klára Aldorfová, Matyas Fendrych, and Viktor Žárský. “EXO70C2 Is a Key Regulatory Factor for Optimal Tip Growth of Pollen.” <i>Plant Physiology</i>. American Society of Plant Biologists, 2017. <a href=\"https://doi.org/10.1104/pp.16.01282\">https://doi.org/10.1104/pp.16.01282</a>.","apa":"Synek, L., Vukašinović, N., Kulich, I., Hála, M., Aldorfová, K., Fendrych, M., &#38; Žárský, V. (2017). EXO70C2 is a key regulatory factor for optimal tip growth of pollen. <i>Plant Physiology</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1104/pp.16.01282\">https://doi.org/10.1104/pp.16.01282</a>","ama":"Synek L, Vukašinović N, Kulich I, et al. EXO70C2 is a key regulatory factor for optimal tip growth of pollen. <i>Plant Physiology</i>. 2017;174(1):223-240. doi:<a href=\"https://doi.org/10.1104/pp.16.01282\">10.1104/pp.16.01282</a>"},"date_published":"2017-05-01T00:00:00Z","file_date_updated":"2020-07-14T12:47:37Z","publication":"Plant Physiology","publication_status":"published","pmid":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","abstract":[{"text":"The exocyst, a eukaryotic tethering complex, coregulates targeted exocytosis as an effector of small GTPases in polarized cell growth. In land plants, several exocyst subunits are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs. Out of 23 Arabidopsis thaliana EXO70 isoforms, we analyzed seven isoforms expressed in pollen. Genetic and microscopic analyses of single mutants in EXO70A2, EXO70C1, EXO70C2, EXO70F1, EXO70H3, EXO70H5, and EXO70H6 genes revealed that only a loss-of-function EXO70C2 allele resulted in a significant male-specific transmission defect (segregation 40%:51%:9%) due to aberrant pollen tube growth. Mutant pollen tubes grown in vitro exhibited an enhanced growth rate and a decreased thickness of the tip cell wall, causing tip bursts. However, exo70C2 pollen tubes could frequently recover and restart their speedy elongation, resulting in a repetitive stop-and-go growth dynamics. A pollenspecific depletion of the closest paralog, EXO70C1, using artificial microRNA in the exo70C2 mutant background, resulted in a complete pollen-specific transmission defect, suggesting redundant functions of EXO70C1 and EXO70C2. Both EXO70C1 and EXO70C2, GFP tagged and expressed under the control of their native promoters, localized in the cytoplasm of pollen grains, pollen tubes, and also root trichoblast cells. The expression of EXO70C2-GFP complemented the aberrant growth of exo70C2 pollen tubes. The absent EXO70C2 interactions with core exocyst subunits in the yeast two-hybrid assay, cytoplasmic localization, and genetic effect suggest an unconventional EXO70 function possibly as a regulator of exocytosis outside the exocyst complex. In conclusion, EXO70C2 is a novel factor contributing to the regulation of optimal tip growth of Arabidopsis pollen tubes. ","lang":"eng"}],"date_updated":"2025-09-11T07:02:41Z","author":[{"full_name":"Synek, Lukáš","last_name":"Synek","first_name":"Lukáš"},{"last_name":"Vukašinović","first_name":"Nemanja","full_name":"Vukašinović, Nemanja"},{"first_name":"Ivan","last_name":"Kulich","full_name":"Kulich, Ivan"},{"full_name":"Hála, Michal","last_name":"Hála","first_name":"Michal"},{"full_name":"Aldorfová, Klára","last_name":"Aldorfová","first_name":"Klára"},{"full_name":"Fendrych, Matyas","id":"43905548-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9767-8699","first_name":"Matyas","last_name":"Fendrych"},{"first_name":"Viktor","last_name":"Žárský","full_name":"Žárský, Viktor"}],"title":"EXO70C2 is a key regulatory factor for optimal tip growth of pollen","external_id":{"pmid":["28356503"],"isi":["000402057200017"]},"date_created":"2018-12-11T11:47:49Z","type":"journal_article","status":"public","publication_identifier":{"issn":["0032-0889"]},"volume":174,"page":"223 - 240","has_accepted_license":"1","doi":"10.1104/pp.16.01282","issue":"1","language":[{"iso":"eng"}],"file":[{"date_created":"2019-11-18T16:16:18Z","relation":"main_file","date_updated":"2020-07-14T12:47:37Z","file_name":"2017_PlantPhysio_Synek.pdf","file_size":2176903,"content_type":"application/pdf","checksum":"97155acc6aa5f0d0a78e0589a932fe02","file_id":"7041","access_level":"open_access","creator":"dernst"}],"oa":1,"year":"2017","isi":1,"month":"05"},{"type":"journal_article","volume":36,"publication_identifier":{"issn":["01677055"]},"status":"public","oa":1,"year":"2017","language":[{"iso":"eng"}],"page":"95 - 106","issue":"2","doi":"10.1111/cgf.13110","month":"05","isi":1,"article_type":"original","scopus_import":"1","department":[{"_id":"ChWo"}],"intvolume":"        36","day":"01","article_processing_charge":"No","oa_version":"Published Version","_id":"670","quality_controlled":"1","citation":{"ama":"Schreck C, Rohmer D, Hahmann S. Interactive paper tearing. <i>Computer Graphics Forum</i>. 2017;36(2):95-106. doi:<a href=\"https://doi.org/10.1111/cgf.13110\">10.1111/cgf.13110</a>","apa":"Schreck, C., Rohmer, D., &#38; Hahmann, S. (2017). Interactive paper tearing. <i>Computer Graphics Forum</i>. Wiley. <a href=\"https://doi.org/10.1111/cgf.13110\">https://doi.org/10.1111/cgf.13110</a>","chicago":"Schreck, Camille, Damien Rohmer, and Stefanie Hahmann. “Interactive Paper Tearing.” <i>Computer Graphics Forum</i>. Wiley, 2017. <a href=\"https://doi.org/10.1111/cgf.13110\">https://doi.org/10.1111/cgf.13110</a>.","ista":"Schreck C, Rohmer D, Hahmann S. 2017. Interactive paper tearing. Computer Graphics Forum. 36(2), 95–106.","ieee":"C. Schreck, D. Rohmer, and S. Hahmann, “Interactive paper tearing,” <i>Computer Graphics Forum</i>, vol. 36, no. 2. Wiley, pp. 95–106, 2017.","short":"C. Schreck, D. Rohmer, S. Hahmann, Computer Graphics Forum 36 (2017) 95–106.","mla":"Schreck, Camille, et al. “Interactive Paper Tearing.” <i>Computer Graphics Forum</i>, vol. 36, no. 2, Wiley, 2017, pp. 95–106, doi:<a href=\"https://doi.org/10.1111/cgf.13110\">10.1111/cgf.13110</a>."},"ddc":["000"],"publist_id":"7056","publisher":"Wiley","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Computer Graphics Forum","date_published":"2017-05-01T00:00:00Z","project":[{"_id":"25357BD2-B435-11E9-9278-68D0E5697425","grant_number":"P 24352-N23","name":"Deep Pictures: Creating Visual and Haptic Vector Images","call_identifier":"FWF"}],"title":"Interactive paper tearing","author":[{"id":"2B14B676-F248-11E8-B48F-1D18A9856A87","full_name":"Schreck, Camille","last_name":"Schreck","first_name":"Camille"},{"full_name":"Rohmer, Damien","first_name":"Damien","last_name":"Rohmer"},{"full_name":"Hahmann, Stefanie","first_name":"Stefanie","last_name":"Hahmann"}],"date_created":"2018-12-11T11:47:49Z","external_id":{"isi":["000404474000011"]},"main_file_link":[{"open_access":"1","url":"https://hal.inria.fr/hal-01647113/file/eg_2017_schreck_paper_tearing.pdf"}],"date_updated":"2025-09-11T07:02:03Z","abstract":[{"text":"We propose an efficient method to model paper tearing in the context of interactive modeling. The method uses geometrical information to automatically detect potential starting points of tears. We further introduce a new hybrid geometrical and physical-based method to compute the trajectory of tears while procedurally synthesizing high resolution details of the tearing path using a texture based approach. The results obtained are compared with real paper and with previous studies on the expected geometric paths of paper that tears.","lang":"eng"}]},{"ec_funded":1,"status":"public","publication_identifier":{"issn":["0027-8424"]},"volume":114,"type":"journal_article","isi":1,"month":"05","page":"4715 - 4720","doi":"10.1073/pnas.1621239114","issue":"18","language":[{"iso":"eng"}],"oa":1,"year":"2017","publist_id":"7053","publisher":"National Academy of Sciences","citation":{"chicago":"Hilbe, Christian, Vaquero Martinez, Krishnendu Chatterjee, and Martin Nowak. “Memory-n Strategies of Direct Reciprocity.” <i>PNAS</i>. National Academy of Sciences, 2017. <a href=\"https://doi.org/10.1073/pnas.1621239114\">https://doi.org/10.1073/pnas.1621239114</a>.","ama":"Hilbe C, Martinez V, Chatterjee K, Nowak M. Memory-n strategies of direct reciprocity. <i>PNAS</i>. 2017;114(18):4715-4720. doi:<a href=\"https://doi.org/10.1073/pnas.1621239114\">10.1073/pnas.1621239114</a>","apa":"Hilbe, C., Martinez, V., Chatterjee, K., &#38; Nowak, M. (2017). Memory-n strategies of direct reciprocity. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1621239114\">https://doi.org/10.1073/pnas.1621239114</a>","ieee":"C. Hilbe, V. Martinez, K. Chatterjee, and M. Nowak, “Memory-n strategies of direct reciprocity,” <i>PNAS</i>, vol. 114, no. 18. National Academy of Sciences, pp. 4715–4720, 2017.","mla":"Hilbe, Christian, et al. “Memory-n Strategies of Direct Reciprocity.” <i>PNAS</i>, vol. 114, no. 18, National Academy of Sciences, 2017, pp. 4715–20, doi:<a href=\"https://doi.org/10.1073/pnas.1621239114\">10.1073/pnas.1621239114</a>.","short":"C. Hilbe, V. Martinez, K. Chatterjee, M. Nowak, PNAS 114 (2017) 4715–4720.","ista":"Hilbe C, Martinez V, Chatterjee K, Nowak M. 2017. Memory-n strategies of direct reciprocity. PNAS. 114(18), 4715–4720."},"quality_controlled":"1","oa_version":"Published Version","article_processing_charge":"Yes (in subscription journal)","_id":"671","day":"02","department":[{"_id":"KrCh"}],"intvolume":"       114","scopus_import":"1","abstract":[{"text":"Humans routinely use conditionally cooperative strategies when interacting in repeated social dilemmas. They are more likely to cooperate if others cooperated before, and are ready to retaliate if others defected. To capture the emergence of reciprocity, most previous models consider subjects who can only choose from a restricted set of representative strategies, or who react to the outcome of the very last round only. As players memorize more rounds, the dimension of the strategy space increases exponentially. This increasing computational complexity renders simulations for individuals with higher cognitive abilities infeasible, especially if multiplayer interactions are taken into account. Here, we take an axiomatic approach instead. We propose several properties that a robust cooperative strategy for a repeated multiplayer dilemma should have. These properties naturally lead to a unique class of cooperative strategies, which contains the classical Win-Stay Lose-Shift rule as a special case. A comprehensive numerical analysis for the prisoner's dilemma and for the public goods game suggests that strategies of this class readily evolve across various memory-n spaces. Our results reveal that successful strategies depend not only on how cooperative others were in the past but also on the respective context of cooperation.","lang":"eng"}],"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422766/","open_access":"1"}],"date_updated":"2025-09-10T14:28:19Z","author":[{"full_name":"Hilbe, Christian","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5116-955X","last_name":"Hilbe","first_name":"Christian"},{"full_name":"Martinez, Vaquero","last_name":"Martinez","first_name":"Vaquero"},{"first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Martin","last_name":"Nowak","full_name":"Nowak, Martin"}],"title":"Memory-n strategies of direct reciprocity","external_id":{"isi":["000400358000050"],"pmid":["28420786"]},"date_created":"2018-12-11T11:47:50Z","project":[{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications"},{"_id":"2584A770-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification"},{"grant_number":"S11407","name":"Game Theory","call_identifier":"FWF","_id":"25863FF4-B435-11E9-9278-68D0E5697425"}],"corr_author":"1","date_published":"2017-05-02T00:00:00Z","publication":"PNAS","pmid":1,"publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"year":"2017","oa":1,"file":[{"file_name":"IST-2017-900-v1+1_1-s2.0-S2211124717305211-main.pdf","date_updated":"2020-07-14T12:47:38Z","content_type":"application/pdf","file_size":2248814,"checksum":"8fdddaab1f1d76a6ec9ca94dcb6b07a2","relation":"main_file","date_created":"2018-12-12T10:14:54Z","creator":"system","access_level":"open_access","file_id":"5109"}],"language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"issue":"5","doi":"10.1016/j.celrep.2017.04.027","page":"902 - 909","has_accepted_license":"1","month":"05","isi":1,"type":"journal_article","volume":19,"publication_identifier":{"issn":["2211-1247"]},"pubrep_id":"900","status":"public","ec_funded":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publication":"Cell Reports","file_date_updated":"2020-07-14T12:47:38Z","date_published":"2017-05-02T00:00:00Z","corr_author":"1","project":[{"call_identifier":"FP7","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425"},{"grant_number":"Y 564-B12","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FWF","_id":"25A8E5EA-B435-11E9-9278-68D0E5697425"}],"external_id":{"isi":["000402124100002"]},"date_created":"2018-12-11T11:47:50Z","author":[{"first_name":"Kari","last_name":"Vaahtomeri","orcid":"0000-0001-7829-3518","full_name":"Vaahtomeri, Kari","id":"368EE576-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Brown","first_name":"Markus","id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87","full_name":"Brown, Markus"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","first_name":"Robert","last_name":"Hauschild"},{"full_name":"De Vries, Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","first_name":"Ingrid","last_name":"De Vries"},{"first_name":"Alexander F","last_name":"Leithner","orcid":"0000-0002-1073-744X","full_name":"Leithner, Alexander F","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-8599-1226","last_name":"Mehling","first_name":"Matthias","id":"3C23B994-F248-11E8-B48F-1D18A9856A87","full_name":"Mehling, Matthias"},{"full_name":"Kaufmann, Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","first_name":"Walter","orcid":"0000-0001-9735-5315"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"title":"Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia","date_updated":"2025-09-10T14:27:34Z","abstract":[{"lang":"eng","text":"Trafficking cells frequently transmigrate through epithelial and endothelial monolayers. How monolayers cooperate with the penetrating cells to support their transit is poorly understood. We studied dendritic cell (DC) entry into lymphatic capillaries as a model system for transendothelial migration. We find that the chemokine CCL21, which is the decisive guidance cue for intravasation, mainly localizes in the trans-Golgi network and intracellular vesicles of lymphatic endothelial cells. Upon DC transmigration, these Golgi deposits disperse and CCL21 becomes extracellularly enriched at the sites of endothelial cell-cell junctions. When we reconstitute the transmigration process in vitro, we find that secretion of CCL21-positive vesicles is triggered by a DC contact-induced calcium signal, and selective calcium chelation in lymphatic endothelium attenuates transmigration. Altogether, our data demonstrate a chemokine-mediated feedback between DCs and lymphatic endothelium, which facilitates transendothelial migration."}],"scopus_import":"1","intvolume":"        19","department":[{"_id":"MiSi"},{"_id":"Bio"},{"_id":"EM-Fac"}],"day":"02","_id":"672","article_processing_charge":"Yes","oa_version":"Published Version","quality_controlled":"1","citation":{"ieee":"K. Vaahtomeri <i>et al.</i>, “Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia,” <i>Cell Reports</i>, vol. 19, no. 5. Cell Press, pp. 902–909, 2017.","mla":"Vaahtomeri, Kari, et al. “Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.” <i>Cell Reports</i>, vol. 19, no. 5, Cell Press, 2017, pp. 902–09, doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.04.027\">10.1016/j.celrep.2017.04.027</a>.","short":"K. Vaahtomeri, M. Brown, R. Hauschild, I. de Vries, A.F. Leithner, M. Mehling, W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.","ista":"Vaahtomeri K, Brown M, Hauschild R, de Vries I, Leithner AF, Mehling M, Kaufmann W, Sixt MK. 2017. Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia. Cell Reports. 19(5), 902–909.","chicago":"Vaahtomeri, Kari, Markus Brown, Robert Hauschild, Ingrid de Vries, Alexander F Leithner, Matthias Mehling, Walter Kaufmann, and Michael K Sixt. “Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.” <i>Cell Reports</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.celrep.2017.04.027\">https://doi.org/10.1016/j.celrep.2017.04.027</a>.","apa":"Vaahtomeri, K., Brown, M., Hauschild, R., de Vries, I., Leithner, A. F., Mehling, M., … Sixt, M. K. (2017). Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2017.04.027\">https://doi.org/10.1016/j.celrep.2017.04.027</a>","ama":"Vaahtomeri K, Brown M, Hauschild R, et al. Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia. <i>Cell Reports</i>. 2017;19(5):902-909. doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.04.027\">10.1016/j.celrep.2017.04.027</a>"},"ddc":["570"],"publisher":"Cell Press","publist_id":"7052"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","pmid":1,"publication_status":"published","publication":"Physical Review E","OA_type":"closed access","date_published":"2017-05-10T00:00:00Z","article_number":"053103","corr_author":"1","date_created":"2018-12-11T11:47:50Z","external_id":{"isi":["000401233900007"],"pmid":["28618504"]},"author":[{"id":"2EE67FDC-F248-11E8-B48F-1D18A9856A87","full_name":"Altmeyer, Sebastian","first_name":"Sebastian","last_name":"Altmeyer","orcid":"0000-0001-5964-0203"},{"full_name":"Lueptow, Richard","last_name":"Lueptow","first_name":"Richard"}],"title":"Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical Couette flow","date_updated":"2025-09-10T14:26:12Z","abstract":[{"text":"We present a numerical study of wavy supercritical cylindrical Couette flow between counter-rotating cylinders in which the wavy pattern propagates either prograde with the inner cylinder or retrograde opposite the rotation of the inner cylinder. The wave propagation reversals from prograde to retrograde and vice versa occur at distinct values of the inner cylinder Reynolds number when the associated frequency of the wavy instability vanishes. The reversal occurs for both twofold and threefold symmetric wavy vortices. Moreover, the wave propagation reversal only occurs for sufficiently strong counter-rotation. The flow pattern reversal appears to be intrinsic in the system as either periodic boundary conditions or fixed end wall boundary conditions for different system sizes always result in the wave propagation reversal. We present a detailed bifurcation sequence and parameter space diagram with respect to retrograde behavior of wavy flows. The retrograde propagation of the instability occurs when the inner Reynolds number is about two times the outer Reynolds number. The mechanism for the retrograde propagation is associated with the inviscidly unstable region near the inner cylinder and the direction of the global average azimuthal velocity. Flow dynamics, spatio-temporal behavior, global mean angular velocity, and torque of the flow with the wavy pattern are explored.","lang":"eng"}],"scopus_import":"1","article_type":"original","intvolume":"        95","department":[{"_id":"BjHo"}],"day":"10","_id":"673","article_processing_charge":"No","oa_version":"None","citation":{"ista":"Altmeyer S, Lueptow R. 2017. Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical Couette flow. Physical Review E. 95(5), 053103.","mla":"Altmeyer, Sebastian, and Richard Lueptow. “Wave Propagation Reversal for Wavy Vortices in Wide Gap Counter Rotating Cylindrical Couette Flow.” <i>Physical Review E</i>, vol. 95, no. 5, 053103, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevE.95.053103\">10.1103/PhysRevE.95.053103</a>.","short":"S. Altmeyer, R. Lueptow, Physical Review E 95 (2017).","ieee":"S. Altmeyer and R. Lueptow, “Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical Couette flow,” <i>Physical Review E</i>, vol. 95, no. 5. American Physical Society, 2017.","apa":"Altmeyer, S., &#38; Lueptow, R. (2017). Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical Couette flow. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.95.053103\">https://doi.org/10.1103/PhysRevE.95.053103</a>","ama":"Altmeyer S, Lueptow R. Wave propagation reversal for wavy vortices in wide gap counter rotating cylindrical Couette flow. <i>Physical Review E</i>. 2017;95(5). doi:<a href=\"https://doi.org/10.1103/PhysRevE.95.053103\">10.1103/PhysRevE.95.053103</a>","chicago":"Altmeyer, Sebastian, and Richard Lueptow. “Wave Propagation Reversal for Wavy Vortices in Wide Gap Counter Rotating Cylindrical Couette Flow.” <i>Physical Review E</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevE.95.053103\">https://doi.org/10.1103/PhysRevE.95.053103</a>."},"quality_controlled":"1","publisher":"American Physical Society","publist_id":"7049","year":"2017","language":[{"iso":"eng"}],"doi":"10.1103/PhysRevE.95.053103","issue":"5","month":"05","isi":1,"type":"journal_article","volume":95,"publication_identifier":{"issn":["2470-0045"]},"status":"public"},{"scopus_import":"1","intvolume":"        27","department":[{"_id":"MiSi"},{"_id":"Bio"},{"_id":"NanoFab"}],"day":"09","_id":"674","oa_version":"None","article_processing_charge":"No","citation":{"apa":"Schwarz, J., Bierbaum, V., Vaahtomeri, K., Hauschild, R., Brown, M., de Vries, I., … Sixt, M. K. (2017). Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">https://doi.org/10.1016/j.cub.2017.04.004</a>","ama":"Schwarz J, Bierbaum V, Vaahtomeri K, et al. Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. <i>Current Biology</i>. 2017;27(9):1314-1325. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">10.1016/j.cub.2017.04.004</a>","chicago":"Schwarz, Jan, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid de Vries, Alexander F Leithner, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">https://doi.org/10.1016/j.cub.2017.04.004</a>.","ista":"Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, Leithner AF, Reversat A, Merrin J, Tarrant T, Bollenbach MT, Sixt MK. 2017. Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. Current Biology. 27(9), 1314–1325.","ieee":"J. Schwarz <i>et al.</i>, “Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6,” <i>Current Biology</i>, vol. 27, no. 9. Cell Press, pp. 1314–1325, 2017.","mla":"Schwarz, Jan, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.” <i>Current Biology</i>, vol. 27, no. 9, Cell Press, 2017, pp. 1314–25, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">10.1016/j.cub.2017.04.004</a>.","short":"J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. de Vries, A.F. Leithner, A. Reversat, J. Merrin, T. Tarrant, M.T. Bollenbach, M.K. Sixt, Current Biology 27 (2017) 1314–1325."},"quality_controlled":"1","publist_id":"7050","publisher":"Cell Press","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publication":"Current Biology","date_published":"2017-05-09T00:00:00Z","corr_author":"1","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"_id":"25A8E5EA-B435-11E9-9278-68D0E5697425","grant_number":"Y 564-B12","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","call_identifier":"FWF"}],"date_created":"2018-12-11T11:47:51Z","external_id":{"isi":["000400741700021"]},"author":[{"last_name":"Schwarz","first_name":"Jan","full_name":"Schwarz, Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87"},{"id":"3FD04378-F248-11E8-B48F-1D18A9856A87","full_name":"Bierbaum, Veronika","last_name":"Bierbaum","first_name":"Veronika"},{"first_name":"Kari","last_name":"Vaahtomeri","orcid":"0000-0001-7829-3518","full_name":"Vaahtomeri, Kari","id":"368EE576-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-9843-3522","last_name":"Hauschild","first_name":"Robert","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87"},{"id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87","full_name":"Brown, Markus","first_name":"Markus","last_name":"Brown"},{"full_name":"De Vries, Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","last_name":"De Vries","first_name":"Ingrid"},{"full_name":"Leithner, Alexander F","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander F","last_name":"Leithner","orcid":"0000-0002-1073-744X"},{"id":"35B76592-F248-11E8-B48F-1D18A9856A87","full_name":"Reversat, Anne","last_name":"Reversat","first_name":"Anne","orcid":"0000-0003-0666-8928"},{"last_name":"Merrin","first_name":"Jack","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack"},{"first_name":"Teresa","last_name":"Tarrant","full_name":"Tarrant, Teresa"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","full_name":"Bollenbach, Tobias","last_name":"Bollenbach","first_name":"Tobias","orcid":"0000-0003-4398-476X"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"}],"title":"Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6","date_updated":"2025-09-10T14:26:47Z","abstract":[{"lang":"eng","text":"Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic cells (DCs) toward higher concentrations of immobilized chemokine CCL21. To elucidate how gradient characteristics govern cellular response patterns, we here introduce an in vitro system allowing to track migratory responses of DCs to precisely controlled immobilized gradients of CCL21. We find that haptotactic sensing depends on the absolute CCL21 concentration and local steepness of the gradient, consistent with a scenario where DC directionality is governed by the signal-to-noise ratio of CCL21 binding to the receptor CCR7. We find that the conditions for optimal DC guidance are perfectly provided by the CCL21 gradients we measure in vivo. Furthermore, we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. These findings suggest that stable, tissue-bound CCL21 gradients as sustainable “roads” ensure optimal guidance in vivo."}],"type":"journal_article","volume":27,"publication_identifier":{"issn":["09609822"]},"status":"public","ec_funded":1,"year":"2017","language":[{"iso":"eng"}],"issue":"9","doi":"10.1016/j.cub.2017.04.004","page":"1314 - 1325","month":"05","isi":1},{"citation":{"ama":"Haase J, Bagiante S, Sigg H, Van Bokhoven J. Surface enhanced infrared absorption of chemisorbed carbon monoxide using plasmonic nanoantennas. <i>Optics Letters</i>. 2017;42(10):1931-1934. doi:<a href=\"https://doi.org/10.1364/OL.42.001931\">10.1364/OL.42.001931</a>","apa":"Haase, J., Bagiante, S., Sigg, H., &#38; Van Bokhoven, J. (2017). Surface enhanced infrared absorption of chemisorbed carbon monoxide using plasmonic nanoantennas. <i>Optics Letters</i>. Optica Publishing Group. <a href=\"https://doi.org/10.1364/OL.42.001931\">https://doi.org/10.1364/OL.42.001931</a>","chicago":"Haase, Johannes, Salvatore Bagiante, Hans Sigg, and Jeroen Van Bokhoven. “Surface Enhanced Infrared Absorption of Chemisorbed Carbon Monoxide Using Plasmonic Nanoantennas.” <i>Optics Letters</i>. Optica Publishing Group, 2017. <a href=\"https://doi.org/10.1364/OL.42.001931\">https://doi.org/10.1364/OL.42.001931</a>.","ista":"Haase J, Bagiante S, Sigg H, Van Bokhoven J. 2017. Surface enhanced infrared absorption of chemisorbed carbon monoxide using plasmonic nanoantennas. Optics Letters. 42(10), 1931–1934.","short":"J. Haase, S. Bagiante, H. Sigg, J. Van Bokhoven, Optics Letters 42 (2017) 1931–1934.","mla":"Haase, Johannes, et al. “Surface Enhanced Infrared Absorption of Chemisorbed Carbon Monoxide Using Plasmonic Nanoantennas.” <i>Optics Letters</i>, vol. 42, no. 10, Optica Publishing Group, 2017, pp. 1931–34, doi:<a href=\"https://doi.org/10.1364/OL.42.001931\">10.1364/OL.42.001931</a>.","ieee":"J. Haase, S. Bagiante, H. Sigg, and J. Van Bokhoven, “Surface enhanced infrared absorption of chemisorbed carbon monoxide using plasmonic nanoantennas,” <i>Optics Letters</i>, vol. 42, no. 10. Optica Publishing Group, pp. 1931–1934, 2017."},"quality_controlled":"1","ddc":["530"],"publisher":"Optica Publishing Group","publist_id":"7048","scopus_import":"1","article_type":"original","department":[{"_id":"NanoFab"}],"intvolume":"        42","day":"15","oa_version":"None","article_processing_charge":"No","_id":"675","title":"Surface enhanced infrared absorption of chemisorbed carbon monoxide using plasmonic nanoantennas","author":[{"full_name":"Haase, Johannes","first_name":"Johannes","last_name":"Haase"},{"first_name":"Salvatore","last_name":"Bagiante","orcid":"0000-0002-0122-9603","id":"38ED402E-F248-11E8-B48F-1D18A9856A87","full_name":"Bagiante, Salvatore"},{"full_name":"Sigg, Hans","first_name":"Hans","last_name":"Sigg"},{"first_name":"Jeroen","last_name":"Van Bokhoven","full_name":"Van Bokhoven, Jeroen"}],"date_created":"2018-12-11T11:47:51Z","external_id":{"isi":["000401424900016"]},"date_updated":"2025-09-10T14:25:19Z","abstract":[{"text":"We report the enhancement of infrared absorption of chemisorbed carbon monoxide on platinum in the gap of plasmonic nanoantennas. Our method is based on the self-assembled formation of platinum nanoislands on nanoscopic dipole antenna arrays manufactured via electron beam lithography. We employ systematic variations of the plasmonic antenna resonance to precisely couple to the molecular stretch vibration of carbon monoxide adsorbed on the platinum nanoislands. Ultimately, we reach more than 1500-fold infrared absorption enhancements, allowing for an ultrasensitive detection of a monolayer of chemisorbed carbon monoxide. The developed procedure can be adapted to other metal adsorbents and molecular species and could be utilized for coverage sensing in surface catalytic reactions. ","lang":"eng"}],"publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Optics Letters","date_published":"2017-05-15T00:00:00Z","volume":42,"status":"public","type":"journal_article","month":"05","isi":1,"year":"2017","language":[{"iso":"eng"}],"page":"1931 - 1934","doi":"10.1364/OL.42.001931","issue":"10"},{"isi":1,"month":"05","has_accepted_license":"1","page":"1294 - 1303","issue":"7","doi":"10.1016/j.celrep.2017.04.051","oa":1,"year":"2017","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"access_level":"open_access","creator":"system","file_id":"5171","checksum":"efc7287d9c6354983cb151880e9ad72a","content_type":"application/pdf","file_size":3005610,"date_updated":"2020-07-14T12:47:40Z","file_name":"IST-2017-899-v1+1_1-s2.0-S2211124717305454-main.pdf","date_created":"2018-12-12T10:15:48Z","relation":"main_file"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2211-1247"]},"pubrep_id":"899","status":"public","volume":19,"type":"journal_article","date_updated":"2025-09-10T14:23:55Z","abstract":[{"lang":"eng","text":"The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the causes of the HR defect in INO80-C mutant cells are controversial. Here, we unite previous findings using a system to study HR with high spatial resolution in budding yeast. We find that INO80-C has at least two distinct functions during HR—DNA end resection and presynaptic filament formation. Importantly, the second function is linked to the histone variant H2A.Z. In the absence of H2A.Z, presynaptic filament formation and HR are restored in INO80-C-deficient mutants, suggesting that presynaptic filament formation is the crucial INO80-C function during HR."}],"author":[{"first_name":"Claudio","last_name":"Lademann","full_name":"Lademann, Claudio"},{"id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","full_name":"Renkawitz, Jörg","first_name":"Jörg","last_name":"Renkawitz","orcid":"0000-0003-2856-3369"},{"last_name":"Pfander","first_name":"Boris","full_name":"Pfander, Boris"},{"full_name":"Jentsch, Stefan","last_name":"Jentsch","first_name":"Stefan"}],"title":"The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination","external_id":{"isi":["000402125100002"]},"date_created":"2018-12-11T11:47:52Z","date_published":"2017-05-16T00:00:00Z","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2020-07-14T12:47:40Z","publication":"Cell Reports","publisher":"Cell Press","publist_id":"7046","quality_controlled":"1","citation":{"chicago":"Lademann, Claudio, Jörg Renkawitz, Boris Pfander, and Stefan Jentsch. “The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination.” <i>Cell Reports</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.celrep.2017.04.051\">https://doi.org/10.1016/j.celrep.2017.04.051</a>.","apa":"Lademann, C., Renkawitz, J., Pfander, B., &#38; Jentsch, S. (2017). The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2017.04.051\">https://doi.org/10.1016/j.celrep.2017.04.051</a>","ama":"Lademann C, Renkawitz J, Pfander B, Jentsch S. The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination. <i>Cell Reports</i>. 2017;19(7):1294-1303. doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.04.051\">10.1016/j.celrep.2017.04.051</a>","mla":"Lademann, Claudio, et al. “The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination.” <i>Cell Reports</i>, vol. 19, no. 7, Cell Press, 2017, pp. 1294–303, doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.04.051\">10.1016/j.celrep.2017.04.051</a>.","short":"C. Lademann, J. Renkawitz, B. Pfander, S. Jentsch, Cell Reports 19 (2017) 1294–1303.","ieee":"C. Lademann, J. Renkawitz, B. Pfander, and S. Jentsch, “The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination,” <i>Cell Reports</i>, vol. 19, no. 7. Cell Press, pp. 1294–1303, 2017.","ista":"Lademann C, Renkawitz J, Pfander B, Jentsch S. 2017. The INO80 complex removes H2A.Z to promote presynaptic filament formation during homologous recombination. Cell Reports. 19(7), 1294–1303."},"ddc":["570"],"day":"16","oa_version":"Published Version","article_processing_charge":"No","_id":"677","scopus_import":"1","department":[{"_id":"MiSi"}],"intvolume":"        19"},{"project":[{"_id":"25236028-B435-11E9-9278-68D0E5697425","name":"The generation and function of anisotropic tissue tension in zebrafish epiboly","grant_number":"ALTF534-2016"}],"external_id":{"isi":["000402525200003"]},"date_created":"2018-12-11T11:47:53Z","author":[{"id":"2A003F6C-F248-11E8-B48F-1D18A9856A87","full_name":"Petridou, Nicoletta","orcid":"0000-0002-8451-1195","last_name":"Petridou","first_name":"Nicoletta"},{"full_name":"Spiro, Zoltan P","id":"426AD026-F248-11E8-B48F-1D18A9856A87","first_name":"Zoltan P","last_name":"Spiro"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"title":"Multiscale force sensing in development","date_updated":"2025-09-10T14:23:21Z","abstract":[{"text":"The seminal observation that mechanical signals can elicit changes in biochemical signalling within cells, a process commonly termed mechanosensation and mechanotransduction, has revolutionized our understanding of the role of cell mechanics in various fundamental biological processes, such as cell motility, adhesion, proliferation and differentiation. In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.","lang":"eng"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publication":"Nature Cell Biology","date_published":"2017-05-31T00:00:00Z","corr_author":"1","quality_controlled":"1","citation":{"ama":"Petridou N, Spiro ZP, Heisenberg C-PJ. Multiscale force sensing in development. <i>Nature Cell Biology</i>. 2017;19(6):581-588. doi:<a href=\"https://doi.org/10.1038/ncb3524\">10.1038/ncb3524</a>","apa":"Petridou, N., Spiro, Z. P., &#38; Heisenberg, C.-P. J. (2017). Multiscale force sensing in development. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb3524\">https://doi.org/10.1038/ncb3524</a>","chicago":"Petridou, Nicoletta, Zoltan P Spiro, and Carl-Philipp J Heisenberg. “Multiscale Force Sensing in Development.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/ncb3524\">https://doi.org/10.1038/ncb3524</a>.","ista":"Petridou N, Spiro ZP, Heisenberg C-PJ. 2017. Multiscale force sensing in development. Nature Cell Biology. 19(6), 581–588.","short":"N. Petridou, Z.P. Spiro, C.-P.J. Heisenberg, Nature Cell Biology 19 (2017) 581–588.","mla":"Petridou, Nicoletta, et al. “Multiscale Force Sensing in Development.” <i>Nature Cell Biology</i>, vol. 19, no. 6, Nature Publishing Group, 2017, pp. 581–88, doi:<a href=\"https://doi.org/10.1038/ncb3524\">10.1038/ncb3524</a>.","ieee":"N. Petridou, Z. P. Spiro, and C.-P. J. Heisenberg, “Multiscale force sensing in development,” <i>Nature Cell Biology</i>, vol. 19, no. 6. Nature Publishing Group, pp. 581–588, 2017."},"publisher":"Nature Publishing Group","publist_id":"7040","scopus_import":"1","intvolume":"        19","department":[{"_id":"CaHe"}],"day":"31","_id":"678","article_processing_charge":"No","oa_version":"None","month":"05","isi":1,"year":"2017","language":[{"iso":"eng"}],"issue":"6","doi":"10.1038/ncb3524","page":"581 - 588","volume":19,"publication_identifier":{"issn":["1465-7392"]},"status":"public","type":"journal_article"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","file_date_updated":"2020-07-14T12:47:40Z","publication":"PLoS Computational Biology","date_published":"2017-06-01T00:00:00Z","article_number":"e1005582","corr_author":"1","external_id":{"isi":["000404565400034"]},"date_created":"2018-12-11T11:47:53Z","title":"Sensory noise predicts divisive reshaping of receptive fields","author":[{"last_name":"Chalk","first_name":"Matthew J","orcid":"0000-0001-7782-4436","id":"2BAAC544-F248-11E8-B48F-1D18A9856A87","full_name":"Chalk, Matthew J"},{"full_name":"Masset, Paul","first_name":"Paul","last_name":"Masset"},{"full_name":"Gutkin, Boris","first_name":"Boris","last_name":"Gutkin"},{"full_name":"Denève, Sophie","first_name":"Sophie","last_name":"Denève"}],"date_updated":"2025-09-10T14:20:48Z","abstract":[{"text":"In order to respond reliably to specific features of their environment, sensory neurons need to integrate multiple incoming noisy signals. Crucially, they also need to compete for the interpretation of those signals with other neurons representing similar features. The form that this competition should take depends critically on the noise corrupting these signals. In this study we show that for the type of noise commonly observed in sensory systems, whose variance scales with the mean signal, sensory neurons should selectively divide their input signals by their predictions, suppressing ambiguous cues while amplifying others. Any change in the stimulus context alters which inputs are suppressed, leading to a deep dynamic reshaping of neural receptive fields going far beyond simple surround suppression. Paradoxically, these highly variable receptive fields go alongside and are in fact required for an invariant representation of external sensory features. In addition to offering a normative account of context-dependent changes in sensory responses, perceptual inference in the presence of signal-dependent noise accounts for ubiquitous features of sensory neurons such as divisive normalization, gain control and contrast dependent temporal dynamics.","lang":"eng"}],"scopus_import":"1","intvolume":"        13","department":[{"_id":"GaTk"}],"day":"01","_id":"680","oa_version":"Published Version","article_processing_charge":"No","citation":{"chicago":"Chalk, Matthew J, Paul Masset, Boris Gutkin, and Sophie Denève. “Sensory Noise Predicts Divisive Reshaping of Receptive Fields.” <i>PLoS Computational Biology</i>. Public Library of Science, 2017. <a href=\"https://doi.org/10.1371/journal.pcbi.1005582\">https://doi.org/10.1371/journal.pcbi.1005582</a>.","ama":"Chalk MJ, Masset P, Gutkin B, Denève S. Sensory noise predicts divisive reshaping of receptive fields. <i>PLoS Computational Biology</i>. 2017;13(6). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1005582\">10.1371/journal.pcbi.1005582</a>","apa":"Chalk, M. J., Masset, P., Gutkin, B., &#38; Denève, S. (2017). Sensory noise predicts divisive reshaping of receptive fields. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1005582\">https://doi.org/10.1371/journal.pcbi.1005582</a>","short":"M.J. Chalk, P. Masset, B. Gutkin, S. Denève, PLoS Computational Biology 13 (2017).","mla":"Chalk, Matthew J., et al. “Sensory Noise Predicts Divisive Reshaping of Receptive Fields.” <i>PLoS Computational Biology</i>, vol. 13, no. 6, e1005582, Public Library of Science, 2017, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1005582\">10.1371/journal.pcbi.1005582</a>.","ieee":"M. J. Chalk, P. Masset, B. Gutkin, and S. Denève, “Sensory noise predicts divisive reshaping of receptive fields,” <i>PLoS Computational Biology</i>, vol. 13, no. 6. Public Library of Science, 2017.","ista":"Chalk MJ, Masset P, Gutkin B, Denève S. 2017. Sensory noise predicts divisive reshaping of receptive fields. PLoS Computational Biology. 13(6), e1005582."},"quality_controlled":"1","ddc":["571"],"publisher":"Public Library of Science","publist_id":"7035","year":"2017","oa":1,"language":[{"iso":"eng"}],"file":[{"file_id":"4645","access_level":"open_access","creator":"system","date_created":"2018-12-12T10:07:47Z","relation":"main_file","checksum":"796a1026076af6f4405a47d985bc7b68","content_type":"application/pdf","file_size":14555676,"date_updated":"2020-07-14T12:47:40Z","file_name":"IST-2017-898-v1+1_journal.pcbi.1005582.pdf"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"issue":"6","doi":"10.1371/journal.pcbi.1005582","has_accepted_license":"1","related_material":{"record":[{"relation":"research_data","status":"public","id":"9855"}]},"month":"06","isi":1,"type":"journal_article","volume":13,"publication_identifier":{"issn":["1553-734X"]},"status":"public","pubrep_id":"898"},{"volume":77,"pubrep_id":"896","status":"public","type":"conference","month":"06","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2018-12-12T10:17:12Z","relation":"main_file","content_type":"application/pdf","file_size":710007,"checksum":"24fdde981cc513352a78dcf9b0660ae9","date_updated":"2020-07-14T12:47:41Z","file_name":"IST-2017-896-v1+1_LIPIcs-SoCG-2017-49.pdf","file_id":"5265","access_level":"open_access","creator":"system"}],"language":[{"iso":"eng"}],"oa":1,"year":"2017","has_accepted_license":"1","related_material":{"record":[{"relation":"later_version","status":"public","id":"5986"}]},"conference":{"start_date":"2017-07-04","end_date":"2017-07-07","location":"Brisbane, Australia","name":"SoCG: Symposium on Computational Geometry"},"doi":"10.4230/LIPIcs.SoCG.2017.49","ddc":["514","516"],"citation":{"chicago":"Lubiw, Anna, Zuzana Masárová, and Uli Wagner. “A Proof of the Orbit Conjecture for Flipping Edge Labelled Triangulations,” Vol. 77. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.49\">https://doi.org/10.4230/LIPIcs.SoCG.2017.49</a>.","apa":"Lubiw, A., Masárová, Z., &#38; Wagner, U. (2017). A proof of the orbit conjecture for flipping edge labelled triangulations (Vol. 77). Presented at the SoCG: Symposium on Computational Geometry, Brisbane, Australia: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.49\">https://doi.org/10.4230/LIPIcs.SoCG.2017.49</a>","ama":"Lubiw A, Masárová Z, Wagner U. A proof of the orbit conjecture for flipping edge labelled triangulations. In: Vol 77. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2017. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.49\">10.4230/LIPIcs.SoCG.2017.49</a>","ieee":"A. Lubiw, Z. Masárová, and U. Wagner, “A proof of the orbit conjecture for flipping edge labelled triangulations,” presented at the SoCG: Symposium on Computational Geometry, Brisbane, Australia, 2017, vol. 77.","mla":"Lubiw, Anna, et al. <i>A Proof of the Orbit Conjecture for Flipping Edge Labelled Triangulations</i>. Vol. 77, 49, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.49\">10.4230/LIPIcs.SoCG.2017.49</a>.","short":"A. Lubiw, Z. Masárová, U. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017.","ista":"Lubiw A, Masárová Z, Wagner U. 2017. A proof of the orbit conjecture for flipping edge labelled triangulations. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 77, 49."},"quality_controlled":"1","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","publist_id":"7033","department":[{"_id":"UlWa"}],"alternative_title":["LIPIcs"],"intvolume":"        77","scopus_import":1,"oa_version":"Published Version","_id":"683","day":"01","author":[{"last_name":"Lubiw","first_name":"Anna","full_name":"Lubiw, Anna"},{"full_name":"Masárová, Zuzana","id":"45CFE238-F248-11E8-B48F-1D18A9856A87","last_name":"Masárová","first_name":"Zuzana","orcid":"0000-0002-6660-1322"},{"orcid":"0000-0002-1494-0568","last_name":"Wagner","first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Uli"}],"title":"A proof of the orbit conjecture for flipping edge labelled triangulations","date_created":"2018-12-11T11:47:54Z","abstract":[{"text":"Given a triangulation of a point set in the plane, a flip deletes an edge e whose removal leaves a convex quadrilateral, and replaces e by the opposite diagonal of the quadrilateral. It is well known that any triangulation of a point set can be reconfigured to any other triangulation by some sequence of flips. We explore this question in the setting where each edge of a triangulation has a label, and a flip transfers the label of the removed edge to the new edge. It is not true that every labelled triangulation of a point set can be reconfigured to every other labelled triangulation via a sequence of flips, but we characterize when this is possible. There is an obvious necessary condition: for each label l, if edge e has label l in the first triangulation and edge f has label l in the second triangulation, then there must be some sequence of flips that moves label l from e to f, ignoring all other labels. Bose, Lubiw, Pathak and Verdonschot formulated the Orbit Conjecture, which states that this necessary condition is also sufficient, i.e. that all labels can be simultaneously mapped to their destination if and only if each label individually can be mapped to its destination. We prove this conjecture. Furthermore, we give a polynomial-time algorithm to find a sequence of flips to reconfigure one labelled triangulation to another, if such a sequence exists, and we prove an upper bound of O(n7) on the length of the flip sequence. Our proof uses the topological result that the sets of pairwise non-crossing edges on a planar point set form a simplicial complex that is homeomorphic to a high-dimensional ball (this follows from a result of Orden and Santos; we give a different proof based on a shelling argument). The dual cell complex of this simplicial ball, called the flip complex, has the usual flip graph as its 1-skeleton. We use properties of the 2-skeleton of the flip complex to prove the Orbit Conjecture.","lang":"eng"}],"date_updated":"2025-04-15T06:53:14Z","file_date_updated":"2020-07-14T12:47:41Z","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","corr_author":"1","article_number":"49","date_published":"2017-06-01T00:00:00Z"},{"status":"public","publication_identifier":{"issn":["0022-4812"],"eissn":["1943-5886"]},"volume":82,"type":"journal_article","isi":1,"arxiv":1,"month":"06","doi":"10.1017/jsl.2016.71","issue":"2","page":"420 - 452","language":[{"iso":"eng"}],"year":"2017","oa":1,"publisher":"Cambridge University Press","publist_id":"7026","citation":{"ista":"Chatterjee K, Piterman N. 2017. Obligation blackwell games and p-automata. Journal of Symbolic Logic. 82(2), 420–452.","ieee":"K. Chatterjee and N. Piterman, “Obligation blackwell games and p-automata,” <i>Journal of Symbolic Logic</i>, vol. 82, no. 2. Cambridge University Press, pp. 420–452, 2017.","short":"K. Chatterjee, N. Piterman, Journal of Symbolic Logic 82 (2017) 420–452.","mla":"Chatterjee, Krishnendu, and Nir Piterman. “Obligation Blackwell Games and P-Automata.” <i>Journal of Symbolic Logic</i>, vol. 82, no. 2, Cambridge University Press, 2017, pp. 420–52, doi:<a href=\"https://doi.org/10.1017/jsl.2016.71\">10.1017/jsl.2016.71</a>.","apa":"Chatterjee, K., &#38; Piterman, N. (2017). Obligation blackwell games and p-automata. <i>Journal of Symbolic Logic</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jsl.2016.71\">https://doi.org/10.1017/jsl.2016.71</a>","ama":"Chatterjee K, Piterman N. Obligation blackwell games and p-automata. <i>Journal of Symbolic Logic</i>. 2017;82(2):420-452. doi:<a href=\"https://doi.org/10.1017/jsl.2016.71\">10.1017/jsl.2016.71</a>","chicago":"Chatterjee, Krishnendu, and Nir Piterman. “Obligation Blackwell Games and P-Automata.” <i>Journal of Symbolic Logic</i>. Cambridge University Press, 2017. <a href=\"https://doi.org/10.1017/jsl.2016.71\">https://doi.org/10.1017/jsl.2016.71</a>."},"quality_controlled":"1","_id":"684","article_processing_charge":"No","oa_version":"Submitted Version","day":"01","intvolume":"        82","department":[{"_id":"KrCh"}],"scopus_import":"1","abstract":[{"text":"We generalize winning conditions in two-player games by adding a structural acceptance condition called obligations. Obligations are orthogonal to the linear winning conditions that define whether a play is winning. Obligations are a declaration that player 0 can achieve a certain value from a configuration. If the obligation is met, the value of that configuration for player 0 is 1. We define the value in such games and show that obligation games are determined. For Markov chains with Borel objectives and obligations, and finite turn-based stochastic parity games with obligations we give an alternative and simpler characterization of the value function. Based on this simpler definition we show that the decision problem of winning finite turn-based stochastic parity games with obligations is in NP∩co-NP. We also show that obligation games provide a game framework for reasoning about p-automata. © 2017 The Association for Symbolic Logic.","lang":"eng"}],"date_updated":"2025-09-10T14:18:30Z","main_file_link":[{"url":"https://arxiv.org/abs/1206.5174","open_access":"1"}],"date_created":"2018-12-11T11:47:54Z","external_id":{"arxiv":["1206.5174"],"isi":["000403796700002"]},"title":"Obligation blackwell games and p-automata","author":[{"orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Piterman","first_name":"Nir","full_name":"Piterman, Nir"}],"corr_author":"1","date_published":"2017-06-01T00:00:00Z","publication":"Journal of Symbolic Logic","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published"},{"status":"public","ec_funded":1,"publisher":"International Conference on Learning Representations","citation":{"ista":"Martius GS, Lampert C. 2017. Extrapolation and learning equations. 5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings. ICLR: International Conference on Learning Representations.","mla":"Martius, Georg S., and Christoph Lampert. “Extrapolation and Learning Equations.” <i>5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings</i>, International Conference on Learning Representations, 2017.","short":"G.S. Martius, C. Lampert, in:, 5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings, International Conference on Learning Representations, 2017.","ieee":"G. S. Martius and C. Lampert, “Extrapolation and learning equations,” in <i>5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings</i>, Toulon, France, 2017.","apa":"Martius, G. S., &#38; Lampert, C. (2017). Extrapolation and learning equations. In <i>5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings</i>. Toulon, France: International Conference on Learning Representations.","ama":"Martius GS, Lampert C. Extrapolation and learning equations. In: <i>5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings</i>. International Conference on Learning Representations; 2017.","chicago":"Martius, Georg S, and Christoph Lampert. “Extrapolation and Learning Equations.” In <i>5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings</i>. International Conference on Learning Representations, 2017."},"quality_controlled":"1","day":"21","_id":"6841","type":"conference","oa_version":"Preprint","scopus_import":1,"department":[{"_id":"ChLa"}],"date_updated":"2021-01-12T08:09:17Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1610.02995"}],"arxiv":1,"abstract":[{"text":"In classical machine learning, regression is treated as a black box process of identifying a suitable function from a hypothesis set without attempting to gain insight into the mechanism connecting inputs and outputs. In the natural sciences, however, finding an interpretable function for a phenomenon is the prime goal as it allows to understand and generalize results. This paper proposes a novel type of function learning network, called equation learner (EQL), that can learn analytical expressions and is able to extrapolate to unseen domains. It is implemented as an end-to-end differentiable feed-forward network and allows for efficient gradient based training. Due to sparsity regularization concise interpretable expressions can be obtained. Often the true underlying source expression is identified.","lang":"eng"}],"month":"02","project":[{"call_identifier":"FP7","name":"Lifelong Learning of Visual Scene Understanding","grant_number":"308036","_id":"2532554C-B435-11E9-9278-68D0E5697425"}],"external_id":{"arxiv":["1610.02995"]},"date_created":"2019-09-01T22:01:00Z","author":[{"full_name":"Martius, Georg S","id":"3A276B68-F248-11E8-B48F-1D18A9856A87","last_name":"Martius","first_name":"Georg S"},{"last_name":"Lampert","first_name":"Christoph","orcid":"0000-0001-8622-7887","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","full_name":"Lampert, Christoph"}],"title":"Extrapolation and learning equations","date_published":"2017-02-21T00:00:00Z","conference":{"location":"Toulon, France","end_date":"2017-04-26","name":"ICLR: International Conference on Learning Representations","start_date":"2017-04-24"},"year":"2017","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1,"publication_status":"published","language":[{"iso":"eng"}],"publication":"5th International Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings"},{"project":[{"call_identifier":"FP7","name":"Arithmetic and physics of Higgs moduli spaces","grant_number":"320593","_id":"25E549F4-B435-11E9-9278-68D0E5697425"}],"author":[{"full_name":"Davison, Ben","id":"4634AB1E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8944-4390","last_name":"Davison","first_name":"Ben"}],"title":"The critical CoHA of a quiver with potential","external_id":{"arxiv":["1311.7172"],"isi":["000404545300015"]},"date_created":"2018-12-11T11:47:55Z","main_file_link":[{"url":"https://arxiv.org/abs/1311.7172","open_access":"1"}],"date_updated":"2025-09-10T14:15:30Z","abstract":[{"text":"Pursuing the similarity between the Kontsevich-Soibelman construction of the cohomological Hall algebra (CoHA) of BPS states and Lusztig's construction of canonical bases for quantum enveloping algebras, and the similarity between the integrality conjecture for motivic Donaldson-Thomas invariants and the PBW theorem for quantum enveloping algebras, we build a coproduct on the CoHA associated to a quiver with potential. We also prove a cohomological dimensional reduction theorem, further linking a special class of CoHAs with Yangians, and explaining how to connect the study of character varieties with the study of CoHAs.","lang":"eng"}],"publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Quarterly Journal of Mathematics","date_published":"2017-06-01T00:00:00Z","corr_author":"1","citation":{"chicago":"Davison, Ben. “The Critical CoHA of a Quiver with Potential.” <i>Quarterly Journal of Mathematics</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/qmath/haw053\">https://doi.org/10.1093/qmath/haw053</a>.","apa":"Davison, B. (2017). The critical CoHA of a quiver with potential. <i>Quarterly Journal of Mathematics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/qmath/haw053\">https://doi.org/10.1093/qmath/haw053</a>","ama":"Davison B. The critical CoHA of a quiver with potential. <i>Quarterly Journal of Mathematics</i>. 2017;68(2):635-703. doi:<a href=\"https://doi.org/10.1093/qmath/haw053\">10.1093/qmath/haw053</a>","mla":"Davison, Ben. “The Critical CoHA of a Quiver with Potential.” <i>Quarterly Journal of Mathematics</i>, vol. 68, no. 2, Oxford University Press, 2017, pp. 635–703, doi:<a href=\"https://doi.org/10.1093/qmath/haw053\">10.1093/qmath/haw053</a>.","short":"B. Davison, Quarterly Journal of Mathematics 68 (2017) 635–703.","ieee":"B. Davison, “The critical CoHA of a quiver with potential,” <i>Quarterly Journal of Mathematics</i>, vol. 68, no. 2. Oxford University Press, pp. 635–703, 2017.","ista":"Davison B. 2017. The critical CoHA of a quiver with potential. Quarterly Journal of Mathematics. 68(2), 635–703."},"quality_controlled":"1","publist_id":"7022","publisher":"Oxford University Press","scopus_import":"1","department":[{"_id":"TaHa"}],"intvolume":"        68","day":"01","oa_version":"Submitted Version","article_processing_charge":"No","_id":"687","month":"06","arxiv":1,"isi":1,"oa":1,"year":"2017","language":[{"iso":"eng"}],"page":"635 - 703","doi":"10.1093/qmath/haw053","issue":"2","volume":68,"publication_identifier":{"issn":["0033-5606"]},"ec_funded":1,"status":"public","type":"journal_article"},{"month":"06","doi":"10.4230/LIPIcs.SoCG.2017.39","has_accepted_license":"1","conference":{"start_date":"2017-07-04","name":"Symposium on Computational Geometry, SoCG","end_date":"2017-07-07","location":"Brisbane, Australia"},"page":"391-3916","year":"2017","oa":1,"language":[{"iso":"eng"}],"file":[{"date_updated":"2020-07-14T12:47:42Z","file_name":"IST-2017-895-v1+1_LIPIcs-SoCG-2017-39.pdf","content_type":"application/pdf","file_size":990546,"checksum":"067ab0cb3f962bae6c3af6bf0094e0f3","relation":"main_file","date_created":"2018-12-12T10:11:03Z","creator":"system","access_level":"open_access","file_id":"4856"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["1868-8969"]},"pubrep_id":"895","status":"public","volume":77,"type":"conference","date_updated":"2025-07-10T11:53:56Z","abstract":[{"text":"We show that the framework of topological data analysis can be extended from metrics to general Bregman divergences, widening the scope of possible applications. Examples are the Kullback - Leibler divergence, which is commonly used for comparing text and images, and the Itakura - Saito divergence, popular for speech and sound. In particular, we prove that appropriately generalized čech and Delaunay (alpha) complexes capture the correct homotopy type, namely that of the corresponding union of Bregman balls. Consequently, their filtrations give the correct persistence diagram, namely the one generated by the uniformly growing Bregman balls. Moreover, we show that unlike the metric setting, the filtration of Vietoris-Rips complexes may fail to approximate the persistence diagram. We propose algorithms to compute the thus generalized čech, Vietoris-Rips and Delaunay complexes and experimentally test their efficiency. Lastly, we explain their surprisingly good performance by making a connection with discrete Morse theory. ","lang":"eng"}],"date_created":"2018-12-11T11:47:56Z","title":"Topological data analysis with Bregman divergences","author":[{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","first_name":"Herbert","last_name":"Edelsbrunner"},{"id":"379CA8B8-F248-11E8-B48F-1D18A9856A87","full_name":"Wagner, Hubert","last_name":"Wagner","first_name":"Hubert"}],"date_published":"2017-06-01T00:00:00Z","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","file_date_updated":"2020-07-14T12:47:42Z","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","publist_id":"7021","citation":{"ieee":"H. Edelsbrunner and H. Wagner, “Topological data analysis with Bregman divergences,” presented at the Symposium on Computational Geometry, SoCG, Brisbane, Australia, 2017, vol. 77, pp. 391–3916.","mla":"Edelsbrunner, Herbert, and Hubert Wagner. <i>Topological Data Analysis with Bregman Divergences</i>. Vol. 77, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017, pp. 391–3916, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.39\">10.4230/LIPIcs.SoCG.2017.39</a>.","short":"H. Edelsbrunner, H. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017, pp. 391–3916.","ista":"Edelsbrunner H, Wagner H. 2017. Topological data analysis with Bregman divergences. Symposium on Computational Geometry, SoCG, LIPIcs, vol. 77, 391–3916.","chicago":"Edelsbrunner, Herbert, and Hubert Wagner. “Topological Data Analysis with Bregman Divergences,” 77:391–3916. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.39\">https://doi.org/10.4230/LIPIcs.SoCG.2017.39</a>.","ama":"Edelsbrunner H, Wagner H. Topological data analysis with Bregman divergences. In: Vol 77. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2017:391-3916. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.39\">10.4230/LIPIcs.SoCG.2017.39</a>","apa":"Edelsbrunner, H., &#38; Wagner, H. (2017). Topological data analysis with Bregman divergences (Vol. 77, pp. 391–3916). Presented at the Symposium on Computational Geometry, SoCG, Brisbane, Australia: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2017.39\">https://doi.org/10.4230/LIPIcs.SoCG.2017.39</a>"},"quality_controlled":"1","ddc":["514","516"],"day":"01","_id":"688","oa_version":"Published Version","article_processing_charge":"No","scopus_import":"1","intvolume":"        77","department":[{"_id":"HeEd"},{"_id":"UlWa"}],"alternative_title":["LIPIcs"]},{"type":"journal_article","volume":9,"publication_identifier":{"issn":["1946-6234"]},"status":"public","year":"2017","language":[{"iso":"eng"}],"issue":"393","doi":"10.1126/scitranslmed.aan8196","month":"06","scopus_import":"1","department":[{"_id":"GaNo"}],"intvolume":"         9","day":"07","article_processing_charge":"No","oa_version":"None","_id":"689","quality_controlled":"1","citation":{"apa":"Novarino, G. (2017). Rett syndrome modeling goes simian. <i>Science Translational Medicine</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/scitranslmed.aan8196\">https://doi.org/10.1126/scitranslmed.aan8196</a>","ama":"Novarino G. Rett syndrome modeling goes simian. <i>Science Translational Medicine</i>. 2017;9(393). doi:<a href=\"https://doi.org/10.1126/scitranslmed.aan8196\">10.1126/scitranslmed.aan8196</a>","chicago":"Novarino, Gaia. “Rett Syndrome Modeling Goes Simian.” <i>Science Translational Medicine</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/scitranslmed.aan8196\">https://doi.org/10.1126/scitranslmed.aan8196</a>.","ista":"Novarino G. 2017. Rett syndrome modeling goes simian. Science Translational Medicine. 9(393), eaan8196.","ieee":"G. Novarino, “Rett syndrome modeling goes simian,” <i>Science Translational Medicine</i>, vol. 9, no. 393. American Association for the Advancement of Science, 2017.","mla":"Novarino, Gaia. “Rett Syndrome Modeling Goes Simian.” <i>Science Translational Medicine</i>, vol. 9, no. 393, eaan8196, American Association for the Advancement of Science, 2017, doi:<a href=\"https://doi.org/10.1126/scitranslmed.aan8196\">10.1126/scitranslmed.aan8196</a>.","short":"G. Novarino, Science Translational Medicine 9 (2017)."},"publist_id":"7019","publisher":"American Association for the Advancement of Science","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Science Translational Medicine","date_published":"2017-06-07T00:00:00Z","corr_author":"1","article_number":"eaan8196","author":[{"orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino","full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"}],"title":"Rett syndrome modeling goes simian","date_created":"2018-12-11T11:47:56Z","date_updated":"2025-07-10T11:54:00Z","abstract":[{"text":"Rett syndrome modeling in monkey mirrors the human disorder.","lang":"eng"}]},{"file_date_updated":"2020-07-14T12:47:44Z","publication":"PNAS","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","pmid":1,"corr_author":"1","date_published":"2017-06-27T00:00:00Z","external_id":{"pmid":["28607047"],"isi":["000404108400028"]},"date_created":"2018-12-11T11:47:57Z","title":"Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses","author":[{"full_name":"Miki, Takafumi","first_name":"Takafumi","last_name":"Miki"},{"first_name":"Walter","last_name":"Kaufmann","orcid":"0000-0001-9735-5315","full_name":"Kaufmann, Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Malagon","first_name":"Gerardo","full_name":"Malagon, Gerardo"},{"full_name":"Gomez, Laura","last_name":"Gomez","first_name":"Laura"},{"last_name":"Tabuchi","first_name":"Katsuhiko","full_name":"Tabuchi, Katsuhiko"},{"full_name":"Watanabe, Masahiko","first_name":"Masahiko","last_name":"Watanabe"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"full_name":"Marty, Alain","first_name":"Alain","last_name":"Marty"}],"abstract":[{"text":"Many central synapses contain a single presynaptic active zone and a single postsynaptic density. Vesicular release statistics at such “simple synapses” indicate that they contain a small complement of docking sites where vesicles repetitively dock and fuse. In this work, we investigate functional and morphological aspects of docking sites at simple synapses made between cerebellar parallel fibers and molecular layer interneurons. Using immunogold labeling of SDS-treated freeze-fracture replicas, we find that Cav2.1 channels form several clusters per active zone with about nine channels per cluster. The mean value and range of intersynaptic variation are similar for Cav2.1 cluster numbers and for functional estimates of docking-site numbers obtained from the maximum numbers of released vesicles per action potential. Both numbers grow in relation with synaptic size and decrease by a similar extent with age between 2 wk and 4 wk postnatal. Thus, the mean docking-site numbers were 3.15 at 2 wk (range: 1–10) and 2.03 at 4 wk (range: 1–4), whereas the mean numbers of Cav2.1 clusters were 2.84 at 2 wk (range: 1–8) and 2.37 at 4 wk (range: 1–5). These changes were accompanied by decreases of miniature current amplitude (from 93 pA to 56 pA), active-zone surface area (from 0.0427 μm2 to 0.0234 μm2), and initial success rate (from 0.609 to 0.353), indicating a tightening of synaptic transmission with development. Altogether, these results suggest a close correspondence between the number of functionally defined vesicular docking sites and that of clusters of voltage-gated calcium channels. ","lang":"eng"}],"date_updated":"2025-09-10T14:00:03Z","intvolume":"       114","department":[{"_id":"EM-Fac"},{"_id":"RySh"}],"scopus_import":"1","_id":"693","article_processing_charge":"Yes (in subscription journal)","oa_version":"Published Version","day":"27","ddc":["570"],"quality_controlled":"1","citation":{"mla":"Miki, Takafumi, et al. “Numbers of Presynaptic Ca2+ Channel Clusters Match Those of Functionally Defined Vesicular Docking Sites in Single Central Synapses.” <i>PNAS</i>, vol. 114, no. 26, National Academy of Sciences, 2017, pp. E5246–55, doi:<a href=\"https://doi.org/10.1073/pnas.1704470114\">10.1073/pnas.1704470114</a>.","short":"T. Miki, W. Kaufmann, G. Malagon, L. Gomez, K. Tabuchi, M. Watanabe, R. Shigemoto, A. Marty, PNAS 114 (2017) E5246–E5255.","ieee":"T. Miki <i>et al.</i>, “Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses,” <i>PNAS</i>, vol. 114, no. 26. National Academy of Sciences, pp. E5246–E5255, 2017.","ista":"Miki T, Kaufmann W, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R, Marty A. 2017. Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. PNAS. 114(26), E5246–E5255.","chicago":"Miki, Takafumi, Walter Kaufmann, Gerardo Malagon, Laura Gomez, Katsuhiko Tabuchi, Masahiko Watanabe, Ryuichi Shigemoto, and Alain Marty. “Numbers of Presynaptic Ca2+ Channel Clusters Match Those of Functionally Defined Vesicular Docking Sites in Single Central Synapses.” <i>PNAS</i>. National Academy of Sciences, 2017. <a href=\"https://doi.org/10.1073/pnas.1704470114\">https://doi.org/10.1073/pnas.1704470114</a>.","ama":"Miki T, Kaufmann W, Malagon G, et al. Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. <i>PNAS</i>. 2017;114(26):E5246-E5255. doi:<a href=\"https://doi.org/10.1073/pnas.1704470114\">10.1073/pnas.1704470114</a>","apa":"Miki, T., Kaufmann, W., Malagon, G., Gomez, L., Tabuchi, K., Watanabe, M., … Marty, A. (2017). Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1704470114\">https://doi.org/10.1073/pnas.1704470114</a>"},"publist_id":"7013","publisher":"National Academy of Sciences","language":[{"iso":"eng"}],"file":[{"relation":"main_file","date_created":"2020-01-03T13:27:29Z","file_name":"2017_PNAS_Miki.pdf","date_updated":"2020-07-14T12:47:44Z","checksum":"2ab75d554f3df4a34d20fa8040589b7e","content_type":"application/pdf","file_size":2721544,"file_id":"7223","creator":"kschuh","access_level":"open_access"}],"year":"2017","oa":1,"doi":"10.1073/pnas.1704470114","issue":"26","page":"E5246 - E5255","has_accepted_license":"1","month":"06","isi":1,"type":"journal_article","volume":114,"status":"public","publication_identifier":{"issn":["0027-8424"]}},{"title":"A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity","author":[{"full_name":"Veß, Astrid","first_name":"Astrid","last_name":"Veß"},{"first_name":"Ulrich","last_name":"Blache","full_name":"Blache, Ulrich"},{"full_name":"Leitner, Laura","last_name":"Leitner","first_name":"Laura"},{"full_name":"Kurz, Angela","last_name":"Kurz","first_name":"Angela"},{"last_name":"Ehrenpfordt","first_name":"Anja","full_name":"Ehrenpfordt, Anja"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179"},{"last_name":"Posern","first_name":"Guido","full_name":"Posern, Guido"}],"date_created":"2018-12-11T11:47:58Z","external_id":{"pmid":["28515231"],"isi":["000405612200009"]},"date_updated":"2025-09-10T11:13:35Z","abstract":[{"text":"A change regarding the extent of adhesion - hereafter referred to as adhesion plasticity - between adhesive and less-adhesive states of mammalian cells is important for their behavior. To investigate adhesion plasticity, we have selected a stable isogenic subpopulation of human MDA-MB-468 breast carcinoma cells growing in suspension. These suspension cells are unable to re-adhere to various matrices or to contract three-dimensional collagen lattices. By using transcriptome analysis, we identified the focal adhesion protein tensin3 (Tns3) as a determinant of adhesion plasticity. Tns3 is strongly reduced at mRNA and protein levels in suspension cells. Furthermore, by transiently challenging breast cancer cells to grow under non-adherent conditions markedly reduces Tns3 protein expression, which is regained upon re-adhesion. Stable knockdown of Tns3 in parental MDA-MB-468 cells results in defective adhesion, spreading and migration. Tns3-knockdown cells display impaired structure and dynamics of focal adhesion complexes as determined by immunostaining. Restoration of Tns3 protein expression in suspension cells partially rescues adhesion and focal contact composition. Our work identifies Tns3 as a crucial focal adhesion component regulated by, and functionally contributing to, the switch between adhesive and non-adhesive states in MDA-MB-468 cancer cells.","lang":"eng"}],"pmid":1,"publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication":"Journal of Cell Science","file_date_updated":"2020-07-14T12:47:45Z","date_published":"2017-07-01T00:00:00Z","citation":{"chicago":"Veß, Astrid, Ulrich Blache, Laura Leitner, Angela Kurz, Anja Ehrenpfordt, Michael K Sixt, and Guido Posern. “A Dual Phenotype of MDA MB 468 Cancer Cells Reveals Mutual Regulation of Tensin3 and Adhesion Plasticity.” <i>Journal of Cell Science</i>. Company of Biologists, 2017. <a href=\"https://doi.org/10.1242/jcs.200899\">https://doi.org/10.1242/jcs.200899</a>.","ama":"Veß A, Blache U, Leitner L, et al. A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. <i>Journal of Cell Science</i>. 2017;130(13):2172-2184. doi:<a href=\"https://doi.org/10.1242/jcs.200899\">10.1242/jcs.200899</a>","apa":"Veß, A., Blache, U., Leitner, L., Kurz, A., Ehrenpfordt, A., Sixt, M. K., &#38; Posern, G. (2017). A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. <i>Journal of Cell Science</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.200899\">https://doi.org/10.1242/jcs.200899</a>","ieee":"A. Veß <i>et al.</i>, “A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity,” <i>Journal of Cell Science</i>, vol. 130, no. 13. Company of Biologists, pp. 2172–2184, 2017.","mla":"Veß, Astrid, et al. “A Dual Phenotype of MDA MB 468 Cancer Cells Reveals Mutual Regulation of Tensin3 and Adhesion Plasticity.” <i>Journal of Cell Science</i>, vol. 130, no. 13, Company of Biologists, 2017, pp. 2172–84, doi:<a href=\"https://doi.org/10.1242/jcs.200899\">10.1242/jcs.200899</a>.","short":"A. Veß, U. Blache, L. Leitner, A. Kurz, A. Ehrenpfordt, M.K. Sixt, G. Posern, Journal of Cell Science 130 (2017) 2172–2184.","ista":"Veß A, Blache U, Leitner L, Kurz A, Ehrenpfordt A, Sixt MK, Posern G. 2017. A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. Journal of Cell Science. 130(13), 2172–2184."},"quality_controlled":"1","ddc":["570"],"publist_id":"7008","publisher":"Company of Biologists","article_type":"original","scopus_import":"1","department":[{"_id":"MiSi"}],"intvolume":"       130","day":"01","oa_version":"Published Version","article_processing_charge":"No","_id":"694","month":"07","isi":1,"oa":1,"year":"2017","language":[{"iso":"eng"}],"file":[{"file_id":"6966","creator":"dernst","access_level":"open_access","relation":"main_file","date_created":"2019-10-24T09:43:56Z","date_updated":"2020-07-14T12:47:45Z","file_name":"2017_CellScience_Vess.pdf","file_size":10847596,"content_type":"application/pdf","checksum":"42c81a0a4fc3128883b391c3af3f74bc"}],"page":"2172 - 2184","has_accepted_license":"1","doi":"10.1242/jcs.200899","issue":"13","volume":130,"publication_identifier":{"issn":["0021-9533"]},"status":"public","type":"journal_article"}]