[{"supplementarymaterial":"no","date_created":"2026-10-12T13:57:47Z","language":[{"iso":"eng"}],"type":"journal_article","has_accepted_license":"1","file":[{"file_id":"23139","file_name":"2026_BulletinLondonMathSoc_Grebennikov.pdf","relation":"main_file","date_updated":"2026-10-14T08:37:16Z","file_size":284851,"date_created":"2026-10-14T08:37:16Z","access_level":"open_access","creator":"dernst","success":1,"checksum":"cce830e3fc66174803b91103f5b88a29","content_type":"application/pdf"}],"doi":"10.1112/blms.70510","license":"https://creativecommons.org/licenses/by/4.0/","department":[{"_id":"MaKw"},{"_id":"GradSch"}],"publication_identifier":{"eissn":["1469-2120"],"issn":["0024-6093"]},"mathsc":["05D40","52C10","52C35"],"acknowledgement":"We would like to thank Huy Pham for insightful discussions about the proof approach, and wewould like to thank the anonymous referees for their careful reading and helpful comments. Bothauthors are supported by ERC Starting Grant “RANDSTRUCT” No. 101076777.Open Access funding provided by Institute of Science and Technology Austria.","title":"No‐(k+1)‐in‐line problem for large constant k","day":"01","oa_version":"Published Version","scopus_import":"1","PlanS_conform":"1","citation":{"ama":"Grebennikov A, Kwan MA. No‐(k+1)‐in‐line problem for large constant k. <i>Bulletin of the London Mathematical Society</i>. 2026;58(10). doi:<a href=\"https://doi.org/10.1112/blms.70510\">10.1112/blms.70510</a>","chicago":"Grebennikov, Aleksandr, and Matthew Alan Kwan. “No‐(K+1)‐in‐line Problem for Large Constant K.” <i>Bulletin of the London Mathematical Society</i>. Wiley, 2026. <a href=\"https://doi.org/10.1112/blms.70510\">https://doi.org/10.1112/blms.70510</a>.","apa":"Grebennikov, A., &#38; Kwan, M. A. (2026). No‐(k+1)‐in‐line problem for large constant k. <i>Bulletin of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/blms.70510\">https://doi.org/10.1112/blms.70510</a>","ista":"Grebennikov A, Kwan MA. 2026. No‐(k+1)‐in‐line problem for large constant k. Bulletin of the London Mathematical Society. 58(10), e70510.","mla":"Grebennikov, Aleksandr, and Matthew Alan Kwan. “No‐(K+1)‐in‐line Problem for Large Constant K.” <i>Bulletin of the London Mathematical Society</i>, vol. 58, no. 10, e70510, Wiley, 2026, doi:<a href=\"https://doi.org/10.1112/blms.70510\">10.1112/blms.70510</a>.","short":"A. Grebennikov, M.A. Kwan, Bulletin of the London Mathematical Society 58 (2026).","ieee":"A. Grebennikov and M. A. Kwan, “No‐(k+1)‐in‐line problem for large constant k,” <i>Bulletin of the London Mathematical Society</i>, vol. 58, no. 10. Wiley, 2026."},"intvolume":"        58","month":"10","corr_author":"1","ddc":["510"],"issue":"10","article_number":"e70510","file_date_updated":"2026-10-14T08:37:16Z","status":"public","publisher":"Wiley","publication_status":"published","date_updated":"2026-10-14T08:41:00Z","OA_type":"hybrid","das_tickbox":"0","date_published":"2026-10-01T00:00:00Z","_id":"23123","OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","researchdata_availability":"no","article_type":"original","author":[{"id":"776468ec-50b0-11ef-861e-96ad19e894f3","first_name":"Aleksandr","last_name":"Grebennikov","full_name":"Grebennikov, Aleksandr"},{"id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","orcid":"0000-0002-4003-7567","last_name":"Kwan","full_name":"Kwan, Matthew Alan","first_name":"Matthew Alan"}],"publication":"Bulletin of the London Mathematical Society","quality_controlled":"1","abstract":[{"text":"How many points can be placed in an 𝑛 × 𝑛 grid sothat every (affine) line contains at most 𝑘 points? Weprove that for 𝑛 ⩾ 𝑘 ⩾ 1037 the maximum number ofpoints is exactly 𝑘𝑛. Our proof builds on the recent workof Kovács, Nagy and Szabó (who proved an analogousresult when 𝑘 is at least about √𝑛 log 𝑛), incorporat-ing ideas of Jain and Pham. Using the same approach,we also obtain new bounds for higher-dimensionalextensions of this problem","lang":"eng"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":58,"fulldoi":"https://doi.org/10.1112/blms.70510","oa":1,"article_processing_charge":"Yes (via OA deal)","project":[{"name":"Randomness and structure in combinatorics","grant_number":"101076777","_id":"bd95085b-d553-11ed-ba76-e55d3349be45"}]},{"tmp":{"short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"fulldoi":"https://doi.org/10.1093/gbe/evag259","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/gbe/evag259"}],"oa":1,"article_processing_charge":"Yes","DOAJ_listed":"1","_id":"23121","external_id":{"biorxivid":["10.64898/2026.02.06.704462"]},"year":"2026","OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Ruzicka, Filip","last_name":"Ruzicka","first_name":"Filip","id":"347955dd-57b0-11ee-9095-c28bdd368f4b"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","last_name":"Vicoso","first_name":"Beatriz"}],"article_type":"original","abstract":[{"lang":"eng","text":"A widespread observation in molecular evolution is that X-linked genes evolve faster—and often adapt faster—than autosomal genes. Three main ideas have been put forward to explain “faster-X” adaptation. The first is that new beneficial mutations are typically partially recessive with respect to fitness, leading to more efficient selection in hemizygous males. The second is that sex differences in recombination, or sex differences in variance in reproductive success, enhance the effective population size on the X chromosome relative to autosomes. Both ideas have limitations: the first conflicts with theories of dominance, in which beneficial mutations are proposed to be partially dominant, while the second only applies to some taxa. Here we tested a third, newly-proposed theory, in which mutations with large “scaled phenotypic effects” (i.e., large effects relative to the distance to a phenotypic optimum) experience more positive selection on the X. Specifically, we used three proxies for scaled phenotypic effects—amino-acid dissimilarity, amino-acid conservation, and gene age—and estimated X and autosomal rates of adaptation of nonsynonymous mutations across effect-size classes. We did this in three lineages with a well-documented faster-X: Drosophila melanogaster, Mus musculus, and Homo sapiens. As expected, we found that large-effect mutations were more likely to be under purifying selection and less likely to be under positive selection than small-effect mutations. However, contrary to the new theory, faster-X adaptation was not enriched among large-effect mutations. Overall, our results highlight an unresolved gap between patterns of sex chromosome evolution and theories of dominance for fitness."}],"quality_controlled":"1","publication":"Genome Biology and Evolution","publication_status":"epub_ahead","date_published":"2026-10-10T00:00:00Z","OA_type":"gold","date_updated":"2026-10-14T08:17:09Z","ddc":["570"],"status":"public","article_number":"evag259","publisher":"Oxford University Press","keyword":["evolutionary biology","population genetics","sex chromosomes","adaptation","genetic divergence","McDonald-Kreitman test","Fisher’s geometric model"],"citation":{"ista":"Ruzicka F, Vicoso B. 2026. Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory. Genome Biology and Evolution., evag259.","apa":"Ruzicka, F., &#38; Vicoso, B. (2026). Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evag259\">https://doi.org/10.1093/gbe/evag259</a>","chicago":"Ruzicka, Filip, and Beatriz Vicoso. “Is Faster-X Adaptation Due to Large-Effect Mutations? An Empirical Test of a New Theory.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/gbe/evag259\">https://doi.org/10.1093/gbe/evag259</a>.","ama":"Ruzicka F, Vicoso B. Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory. <i>Genome Biology and Evolution</i>. 2026. doi:<a href=\"https://doi.org/10.1093/gbe/evag259\">10.1093/gbe/evag259</a>","short":"F. Ruzicka, B. Vicoso, Genome Biology and Evolution (2026).","ieee":"F. Ruzicka and B. Vicoso, “Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory,” <i>Genome Biology and Evolution</i>. Oxford University Press, 2026.","mla":"Ruzicka, Filip, and Beatriz Vicoso. “Is Faster-X Adaptation Due to Large-Effect Mutations? An Empirical Test of a New Theory.” <i>Genome Biology and Evolution</i>, evag259, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/gbe/evag259\">10.1093/gbe/evag259</a>."},"scopus_import":"1","corr_author":"1","month":"10","publication_identifier":{"eissn":["1759-6653"]},"day":"10","biorxivid":1,"title":"Is faster-X adaptation due to large-effect mutations? An empirical test of a new theory","oa_version":"Published Version","date_created":"2026-10-12T13:56:46Z","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1093/gbe/evag259","license":"https://creativecommons.org/licenses/by-nc/4.0/","department":[{"_id":"BeVi"}]},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1093/qmath/haag037","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/qmath/haag037"}],"article_processing_charge":"Yes (via OA deal)","oa":1,"project":[{"name":"Rational curves via function field analytic number theory","grant_number":"P36278","_id":"bd8a4fdc-d553-11ed-ba76-80a0167441a3"}],"publication_status":"epub_ahead","date_published":"2026-10-06T00:00:00Z","das_tickbox":"0","OA_type":"hybrid","date_updated":"2026-10-14T08:49:05Z","_id":"23124","external_id":{"arxiv":["2510.26191"]},"year":"2026","researchdata_availability":"no","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","article_type":"original","author":[{"full_name":"Browning, Timothy D","last_name":"Browning","first_name":"Timothy D","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177"},{"last_name":"Sawin","full_name":"Sawin, Will","first_name":"Will"}],"abstract":[{"lang":"eng","text":"Among the set of hypersurfaces of degree d and dimension  defined by the vanishing\r\nof a homogeneous polynomial with coefficients in the set {−1, +1}, we investigate the\r\nprobability that a hypersurface contains a rational point as d and  tend to ∞."}],"quality_controlled":"1","publication":"The Quarterly Journal of Mathematics","PlanS_conform":"1","citation":{"mla":"Browning, Timothy D., and Will Sawin. “Random Diophantine Equations of Large Degree.” <i>The Quarterly Journal of Mathematics</i>, haag037, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/qmath/haag037\">10.1093/qmath/haag037</a>.","ieee":"T. D. Browning and W. Sawin, “Random diophantine equations of large degree,” <i>The Quarterly Journal of Mathematics</i>. Oxford University Press, 2026.","short":"T.D. Browning, W. Sawin, The Quarterly Journal of Mathematics (2026).","chicago":"Browning, Timothy D, and Will Sawin. “Random Diophantine Equations of Large Degree.” <i>The Quarterly Journal of Mathematics</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/qmath/haag037\">https://doi.org/10.1093/qmath/haag037</a>.","apa":"Browning, T. D., &#38; Sawin, W. (2026). Random diophantine equations of large degree. <i>The Quarterly Journal of Mathematics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/qmath/haag037\">https://doi.org/10.1093/qmath/haag037</a>","ama":"Browning TD, Sawin W. Random diophantine equations of large degree. <i>The Quarterly Journal of Mathematics</i>. 2026. doi:<a href=\"https://doi.org/10.1093/qmath/haag037\">10.1093/qmath/haag037</a>","ista":"Browning TD, Sawin W. 2026. Random diophantine equations of large degree. The Quarterly Journal of Mathematics., haag037."},"scopus_import":"1","corr_author":"1","month":"10","ddc":["500"],"status":"public","arxiv":1,"article_number":"haag037","publisher":"Oxford University Press","date_created":"2026-10-12T13:58:16Z","supplementarymaterial":"no","type":"journal_article","has_accepted_license":"1","language":[{"iso":"eng"}],"doi":"10.1093/qmath/haag037","department":[{"_id":"TiBr"}],"acknowledgement":"The authors are very grateful to Pierre Le Boudec, whose contributions would have merited coauthorship. At his request, however, he is not listed as a co-author, since he has chosen to pursue\r\na career outside academia. T.B. was supported by a grant from the IAS School of Mathematics\r\nand a FWF grant (DOI 10.55776/P36278). W.S. was supported by NSF grant DMS-2502029 and\r\na Sloan Research Fellowship.","publication_identifier":{"eissn":["1464-3847"],"issn":["0033-5606"]},"day":"06","title":"Random diophantine equations of large degree","oa_version":"Published Version"},{"file":[{"creator":"ateplova","checksum":"ae6e37780e4a8d07cfabf0a899c6c6bf","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","date_created":"2026-09-25T09:19:25Z","file_id":"22996","file_size":106736394,"date_updated":"2026-09-25T09:19:25Z","relation":"source_file","file_name":"2026-Teplova-Anastasia-Thesis-final.docx"},{"embargo_to":"open_access","creator":"ateplova","embargo":"2027-09-30","checksum":"305099d360d30bd596af946171d19c3b","content_type":"application/pdf","access_level":"closed","date_created":"2026-09-25T09:25:56Z","file_id":"22997","file_name":"2026-Teplova-Anastasia-Thesis-final-pdfA.pdf","file_size":39343452,"date_updated":"2026-09-25T09:25:56Z","relation":"main_file"}],"department":[{"_id":"GradSch"},{"_id":"JiFr"}],"doi":"10.15479/AT-ISTA-22984","language":[{"iso":"eng"}],"has_accepted_license":"1","type":"dissertation","date_created":"2026-09-23T15:29:42Z","alternative_title":["ISTA Thesis"],"oa_version":"Published Version","title":"Chasing the elusive: Investigating nucleotide cyclase activity in gibberellin and strigolactone signalling; Cellular mechanisms of gravity sensing and response in roots","page":"190","day":"23","publication_identifier":{"isbn":["978-3-99078-093-0"],"issn":["2663-337X "]},"degree_awarded":"PhD","month":"09","corr_author":"1","doi_confirm":"1","citation":{"short":"A. Teplova, Chasing the Elusive: Investigating Nucleotide Cyclase Activity in Gibberellin and Strigolactone Signalling; Cellular Mechanisms of Gravity Sensing and Response in Roots, Institute of Science and Technology Austria, 2026.","ieee":"A. Teplova, “Chasing the elusive: Investigating nucleotide cyclase activity in gibberellin and strigolactone signalling; Cellular mechanisms of gravity sensing and response in roots,” Institute of Science and Technology Austria, 2026.","mla":"Teplova, Anastasiia. <i>Chasing the Elusive: Investigating Nucleotide Cyclase Activity in Gibberellin and Strigolactone Signalling; Cellular Mechanisms of Gravity Sensing and Response in Roots</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22984\">10.15479/AT-ISTA-22984</a>.","ista":"Teplova A. 2026. Chasing the elusive: Investigating nucleotide cyclase activity in gibberellin and strigolactone signalling; Cellular mechanisms of gravity sensing and response in roots. Institute of Science and Technology Austria.","chicago":"Teplova, Anastasiia. “Chasing the Elusive: Investigating Nucleotide Cyclase Activity in Gibberellin and Strigolactone Signalling; Cellular Mechanisms of Gravity Sensing and Response in Roots.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22984\">https://doi.org/10.15479/AT-ISTA-22984</a>.","ama":"Teplova A. Chasing the elusive: Investigating nucleotide cyclase activity in gibberellin and strigolactone signalling; Cellular mechanisms of gravity sensing and response in roots. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22984\">10.15479/AT-ISTA-22984</a>","apa":"Teplova, A. (2026). <i>Chasing the elusive: Investigating nucleotide cyclase activity in gibberellin and strigolactone signalling; Cellular mechanisms of gravity sensing and response in roots</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22984\">https://doi.org/10.15479/AT-ISTA-22984</a>"},"publisher":"Institute of Science and Technology Austria","file_date_updated":"2026-09-25T09:25:56Z","status":"public","ddc":["570"],"date_updated":"2026-10-15T08:30:03Z","date_published":"2026-09-23T00:00:00Z","publication_status":"published","related_material":{"record":[{"relation":"part_of_dissertation","id":"15257","status":"public"}]},"author":[{"full_name":"Teplova, Anastasiia","last_name":"Teplova","first_name":"Anastasiia","id":"e3736151-106c-11ec-b916-c2558e2762c6"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_place":"publisher","year":"2026","_id":"22984","article_processing_charge":"No","supervisor":[{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","full_name":"Friml, Jiří","last_name":"Friml"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22984","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"MassSpec"}]},{"related_material":{"record":[{"relation":"part_of_dissertation","id":"21281","status":"public"},{"status":"public","id":"17099","relation":"part_of_dissertation"}]},"author":[{"last_name":"Asadi","full_name":"Asadi, Ali","first_name":"Ali","id":"02d96aae-000e-11ec-b801-cadd0a5eefbb"}],"abstract":[{"text":"We study the computational aspects of the two central solution concepts of stochastic games\r\nplayed on finite graphs for an infinite number of steps: the value in two-player zero-sum\r\ngames, and Nash equilibria in multi-player games. In both settings, exact solutions are in\r\ntractable. Fortwo-playerzero-sumconcurrentstochasticgames,valuescanbeirrational,and\r\nthe associated decision problem is SQRT-SUM hard. For multi-player turn-based stochastic\r\ngames,theequilibriumprobabilitiescanbeirrational,anddecidingtheconstrainedexistence\r\nof a Nash equilibrium is undecidable in the presence of memory, and ∃R-complete when the\r\nplayers are restricted to stationary strategies. Hence, in both settings, the natural computational problem is the approximation of the solution within an arbitrary additive error. In\r\nthis thesis, we present improved complexity results and algorithms for such approximation\r\nproblems.\r\nThe first part of the thesis considers two-player zero-sum concurrent stochastic games\r\nwith two classic objectives: (a) stateful-discounted objectives, which are similar to the classic\r\ndiscounted-sum objectives, but states are associated with different discount factors rather\r\nthan a single discount factor; and (b) parity objectives, which are a canonical representation\r\nfor ω-regular objectives. For stateful-discounted objectives, given an ordering of the discount\r\nfactors, the limit value is the limit of the value of the stateful-discounted objectives, as\r\nthe discount factors approach zero according to the given order. The value-approximation\r\nproblem is known to be in EXPSPACE for the limit value of stateful-discounted objectives and\r\nin PSPACEforparityobjectives,andthebest-knownalgorithmsforbothproblemsareatleast\r\nexponential time, with an exponential dependence on the number of states and actions. Our\r\nmain results for the value-approximation problem for the limit value of stateful-discounted\r\nobjectives and parity objectives areas follows: (a)we establish TFNPNP complexity; and (b)we\r\npresent algorithms that improve the dependency on the number of actions in the exponent\r\nfrom linear to logarithmic. In particular, if the number of states is constant, our algorithms\r\nrun in polynomial time.\r\nThe second part of the thesis considers multi-player turn-based stochastic games with\r\nterminal payoffs, where the players are restricted to stationary strategies. We study the\r\napproximate constrained existence problem of Nash equilibria: given a game that has a Nash\r\nequilibrium in which the payoff of every player lies in a given interval, compute a strategy\r\nprofile that is an ε-Nash equilibrium and that satisfies the same constraints up to an additive\r\nerror ε. Our main results are as follows: (a) we present an FNPNP algorithm for the problem;\r\nand(b)we establish that its decision version is NP-hard, already with two players. For the\r\nupperbound,weshowthatifaconstrainedNashequilibriumexists,thenthereexists one\r\nin which the non-zero probabilities are at least an inverse of a double-exponential in the\r\ni\r\ninput size, and that such a strategy profile can be represented, up to an additive error ε, with\r\nfloating-point numbers of polynomial size. We complement the upper bound with a lower\r\nbound on this approach: we present a game with only five players in which every constrained\r\nNash equilibrium requires double-exponentially small probabilities.\r\nThe two parts share a common technical toolkit: bounds on solutions of systems of\r\npolynomial inequalities that arise from real algebraic geometry, the floating-point representation of doubly-exponentially small numbers, and guess-and-verify procedures that resolve\r\nsingle-player games with an NP oracle.","lang":"eng"}],"_id":"23079","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_place":"publisher","year":"2026","date_updated":"2026-10-16T08:00:45Z","ec_funded":1,"date_published":"2026-10-09T00:00:00Z","publication_status":"published","project":[{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","call_identifier":"H2020","grant_number":"863818","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E"},{"_id":"4029cfc7-b034-11f1-9e55-88ab2ff3b6ee","grant_number":"COE12","name":"Bilateral Artificial Intelligence (Chatterjee)"},{"grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software"}],"article_processing_charge":"No","oa":1,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.15479/AT-ISTA-23079","supervisor":[{"orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu"}],"oa_version":"Published Version","publication_identifier":{"issn":["2791-4585"]},"acknowledgement":"The research reported in Part I was partially supported by the European Research\r\nCouncil (ERC) Consolidator Grant 863818 (ForM-SMArt), by the Austrian Science Fund\r\n(FWF) 10.55776/COE12, and by the French Agence Nationale de la Recherche (ANR) grant\r\nANR-21-CE40-0020 (CONVERGENCE project). The research reported in Part II is a part of\r\nproject VAMOS, which has received funding from the European Research Council (ERC) under\r\ngrant agreement No.101020093.","page":"83","title":"Approximation of values and equilibria in stochastic games: Complexity and algorithms","day":"09","file":[{"checksum":"c6b368f342409de884eafdd3af7867c5","content_type":"application/pdf","creator":"aasadi","date_updated":"2026-10-12T13:13:51Z","relation":"main_file","file_size":694682,"file_name":"2026_Asadi_Ali_Thesis.pdf","file_id":"23081","date_created":"2026-10-09T11:12:08Z","access_level":"open_access"},{"creator":"aasadi","content_type":"application/zip","checksum":"71ecb0b666438f395a92b395e315f904","file_id":"23082","relation":"source_file","date_updated":"2026-10-09T11:47:47Z","file_size":1538723,"file_name":"2026_Asadi_Ali_Thesis.zip","date_created":"2026-10-09T11:12:56Z","access_level":"closed"}],"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"doi":"10.15479/AT-ISTA-23079","date_created":"2026-10-08T09:07:53Z","alternative_title":["ISTA Master’s Thesis"],"language":[{"iso":"eng"}],"type":"dissertation","has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","ddc":["000"],"file_date_updated":"2026-10-12T13:13:51Z","status":"public","month":"10","corr_author":"1","degree_awarded":"MS","citation":{"chicago":"Asadi, Ali. “Approximation of Values and Equilibria in Stochastic Games: Complexity and Algorithms.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-23079\">https://doi.org/10.15479/AT-ISTA-23079</a>.","apa":"Asadi, A. (2026). <i>Approximation of values and equilibria in stochastic games: Complexity and algorithms</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-23079\">https://doi.org/10.15479/AT-ISTA-23079</a>","ama":"Asadi A. Approximation of values and equilibria in stochastic games: Complexity and algorithms. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-23079\">10.15479/AT-ISTA-23079</a>","ista":"Asadi A. 2026. Approximation of values and equilibria in stochastic games: Complexity and algorithms. Institute of Science and Technology Austria.","mla":"Asadi, Ali. <i>Approximation of Values and Equilibria in Stochastic Games: Complexity and Algorithms</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-23079\">10.15479/AT-ISTA-23079</a>.","short":"A. Asadi, Approximation of Values and Equilibria in Stochastic Games: Complexity and Algorithms, Institute of Science and Technology Austria, 2026.","ieee":"A. Asadi, “Approximation of values and equilibria in stochastic games: Complexity and algorithms,” Institute of Science and Technology Austria, 2026."},"doi_confirm":"1"},{"publisher":"Institute of Science and Technology Austria","status":"public","file_date_updated":"2026-08-07T10:16:07Z","ddc":["540","546","530"],"degree_awarded":"PhD","corr_author":"1","month":"08","doi_confirm":"1","citation":{"ista":"Fiedler C. 2026. Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs. Institute of Science and Technology Austria.","chicago":"Fiedler, Christine. “Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22626\">https://doi.org/10.15479/AT-ISTA-22626</a>.","apa":"Fiedler, C. (2026). <i>Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22626\">https://doi.org/10.15479/AT-ISTA-22626</a>","ama":"Fiedler C. Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22626\">10.15479/AT-ISTA-22626</a>","ieee":"C. Fiedler, “Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs,” Institute of Science and Technology Austria, 2026.","short":"C. Fiedler, Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs, Institute of Science and Technology Austria, 2026.","mla":"Fiedler, Christine. <i>Mechanistic Insight into Solution-Processed p-Type Tin Chalcogenides as a Basis for Designing Their n-Type Analogs</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22626\">10.15479/AT-ISTA-22626</a>."},"oa_version":"Published Version","day":"05","page":"141","title":"Mechanistic insight into solution-processed p-type tin chalcogenides as a basis for designing their n-type analogs","acknowledgement":"This thesis and the publications within, were financially supported by the Institute of Science and Technology Austria and the Werner Siemens Foundation under the project “High Thermoelectric Materials: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery”.","publication_identifier":{"isbn":["978-3-99078-086-2"],"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-22626","department":[{"_id":"GradSch"},{"_id":"MaIb"}],"file":[{"creator":"cfiedler","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","checksum":"4f357f3c0f5ee3d679dd0395dbafc4bb","file_id":"22659","file_name":"2026_Fiedler_Christine_Thesis.docx","file_size":625541367,"date_updated":"2026-08-07T10:02:41Z","relation":"source_file","date_created":"2026-08-07T09:10:56Z","access_level":"closed"},{"embargo":"2027-02-07","creator":"cfiedler","checksum":"69784d2e7b9ef3d3a0fbe134f3bba089","content_type":"application/pdf","embargo_to":"open_access","file_id":"22660","file_size":16646551,"date_updated":"2026-08-07T10:16:07Z","relation":"main_file","file_name":"2026_Fiedler_Christine_Thesis.pdf","date_created":"2026-08-07T09:10:45Z","access_level":"closed"}],"type":"dissertation","has_accepted_license":"1","language":[{"iso":"eng"}],"date_created":"2026-08-03T07:55:16Z","alternative_title":["ISTA Thesis"],"project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"article_processing_charge":"No","supervisor":[{"first_name":"Maria","last_name":"Ibáñez","full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22626","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"author":[{"full_name":"Fiedler, Christine","last_name":"Fiedler","first_name":"Christine","id":"bd3fceba-dc74-11ea-a0a7-c17f71817366"}],"related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"12237"},{"status":"public","id":"17124","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"17052","status":"public"}]},"year":"2026","OA_place":"publisher","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"22626","date_published":"2026-08-05T00:00:00Z","date_updated":"2026-10-16T09:30:26Z","publication_status":"published"},{"publisher":"Institute of Science and Technology Austria","status":"public","file_date_updated":"2026-07-01T07:35:17Z","ddc":["546","530"],"degree_awarded":"PhD","corr_author":"1","month":"06","doi_confirm":"1","citation":{"short":"T. Kleinhanns, Unraveling the Origin and Evolution of Defects to Enable Advanced Thermoelectric Performance, Institute of Science and Technology Austria, 2026.","ieee":"T. Kleinhanns, “Unraveling the origin and evolution of defects to enable advanced thermoelectric performance,” Institute of Science and Technology Austria, 2026.","mla":"Kleinhanns, Tobias. <i>Unraveling the Origin and Evolution of Defects to Enable Advanced Thermoelectric Performance</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22017\">10.15479/AT-ISTA-22017</a>.","ista":"Kleinhanns T. 2026. Unraveling the origin and evolution of defects to enable advanced thermoelectric performance. Institute of Science and Technology Austria.","ama":"Kleinhanns T. Unraveling the origin and evolution of defects to enable advanced thermoelectric performance. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22017\">10.15479/AT-ISTA-22017</a>","apa":"Kleinhanns, T. (2026). <i>Unraveling the origin and evolution of defects to enable advanced thermoelectric performance</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22017\">https://doi.org/10.15479/AT-ISTA-22017</a>","chicago":"Kleinhanns, Tobias. “Unraveling the Origin and Evolution of Defects to Enable Advanced Thermoelectric Performance.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22017\">https://doi.org/10.15479/AT-ISTA-22017</a>."},"oa_version":"Published Version","day":"18","title":"Unraveling the origin and evolution of defects to enable advanced thermoelectric performance","page":"59","publication_identifier":{"issn":["2663-337X"],"isbn":["978-3-99078-081-7"]},"department":[{"_id":"GradSch"},{"_id":"MaIb"}],"doi":"10.15479/AT-ISTA-22017","file":[{"creator":"tkleinha","checksum":"3df7e865a7d1da8972ccd8acb8b4c16c","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"22226","file_name":"2026_Kleinhanns_Tobias_Thesis_Source_File.docx","relation":"source_file","file_size":15658266,"date_updated":"2026-06-30T09:17:15Z","date_created":"2026-06-30T09:17:15Z","access_level":"closed"},{"file_id":"22232","file_size":9909375,"date_updated":"2026-07-01T07:35:17Z","relation":"main_file","file_name":"2026_Kleinhanns_Tobias_Thesis_Main_File_A4.pdf","access_level":"closed","date_created":"2026-07-01T07:35:17Z","embargo":"2026-12-18","creator":"tkleinha","checksum":"40ec279272a963636ff29c964032dcba","content_type":"application/pdf","embargo_to":"open_access"}],"type":"dissertation","has_accepted_license":"1","language":[{"iso":"eng"}],"alternative_title":["ISTA Thesis"],"date_created":"2026-06-18T08:00:03Z","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"article_processing_charge":"No","supervisor":[{"first_name":"Maria","full_name":"Ibáñez, Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22017","author":[{"id":"8BD9DE16-AB3C-11E9-9C8C-2A03E6697425","orcid":"0000-0003-1537-7436","last_name":"Kleinhanns","full_name":"Kleinhanns, Tobias","first_name":"Tobias"}],"related_material":{"record":[{"relation":"part_of_dissertation","id":"12237","status":"public"},{"id":"20326","status":"public","relation":"part_of_dissertation"},{"id":"15182","status":"public","relation":"part_of_dissertation"}]},"year":"2026","OA_place":"publisher","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"22017","date_published":"2026-06-18T00:00:00Z","das_tickbox":"1","date_updated":"2026-10-16T10:07:25Z","publication_status":"published"},{"oa_version":"Published Version","publication_identifier":{"isbn":[" 978-3-99078-087-9"],"issn":["2663-337X"]},"title":"Towards efficient secure group messaging","page":"187","day":"10","file":[{"access_level":"open_access","date_created":"2026-08-13T09:39:00Z","file_name":"2026_CuetoNoval_Miguel_Thesis.pdf","file_size":1390255,"relation":"main_file","date_updated":"2026-08-19T11:36:46Z","file_id":"22702","checksum":"d61beeb9a250a04396c2c61bbd0783aa","content_type":"application/pdf","creator":"mcuetono"},{"access_level":"closed","date_created":"2026-08-13T09:39:01Z","file_name":"2026_CuetoNoval_Miguel_Thesis.zip","date_updated":"2026-08-14T10:26:06Z","relation":"source_file","file_size":9923509,"file_id":"22703","checksum":"4d6def422cc93a108faf5e5defc0f807","content_type":"application/zip","creator":"mcuetono"}],"department":[{"_id":"GradSch"},{"_id":"KrPi"}],"doi":"10.15479/AT-ISTA-22664","date_created":"2026-08-10T10:18:35Z","alternative_title":["ISTA Thesis"],"language":[{"iso":"eng"}],"has_accepted_license":"1","type":"dissertation","publisher":"Institute of Science and Technology Austria","ddc":["000"],"file_date_updated":"2026-08-19T11:36:46Z","status":"public","month":"08","corr_author":"1","degree_awarded":"PhD","citation":{"mla":"Cueto Noval, Miguel. <i>Towards Efficient Secure Group Messaging</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22664\">10.15479/AT-ISTA-22664</a>.","ieee":"M. Cueto Noval, “Towards efficient secure group messaging,” Institute of Science and Technology Austria, 2026.","short":"M. Cueto Noval, Towards Efficient Secure Group Messaging, Institute of Science and Technology Austria, 2026.","apa":"Cueto Noval, M. (2026). <i>Towards efficient secure group messaging</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22664\">https://doi.org/10.15479/AT-ISTA-22664</a>","chicago":"Cueto Noval, Miguel. “Towards Efficient Secure Group Messaging.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22664\">https://doi.org/10.15479/AT-ISTA-22664</a>.","ama":"Cueto Noval M. Towards efficient secure group messaging. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22664\">10.15479/AT-ISTA-22664</a>","ista":"Cueto Noval M. 2026. Towards efficient secure group messaging. Institute of Science and Technology Austria."},"doi_confirm":"1","related_material":{"record":[{"status":"public","id":"21262","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"14691","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"18702"}]},"author":[{"id":"ffc563a3-f6e0-11ea-865d-e3cce03d17cc","orcid":"0000-0002-2505-4246","full_name":"Cueto Noval, Miguel","last_name":"Cueto Noval","first_name":"Miguel"}],"abstract":[{"lang":"eng","text":"The widespread adoption of apps like Whatsapp and Signal has translated into billions of people all around the world communicating on a regular basis by making use of services that offer end-to-end encryption and even provide security guarantees when a user's device is compromised.\r\n\r\nThis was made possible by the introduction of the Double Ratchet Algorithm~\\cite{double_ratchet}, which was designed for a setting where communication takes place between two parties.\r\nHowever, in practice, many apps offer the possibility of creating groups.\r\nThe protocols they use to secure communication are inefficient for large group which has the undesireable consequence that the aforementioned apps have established limits on the group size of roughly 1000 users.\r\nThis has motivated the introduction of the Messaging Layer Security (MLS) standard~\\cite{rfc9420} by the IETF which is based on a primitive called Continuous Group Key Agreement (CGKA)~\\cite{C:ACDT20}.\r\n\r\nThis primitive allows a group of users to maintain a shared secret key that is frequently rotated by the group members in order to change group membership, achieve forward secrecy (FS) and post compromise security (PCS).\r\nMost protocols are based on binary trees where the nodes are associated to a pair formed by public key and a secret key.\r\nEach leaf corresponds to one of the group members and a user knows the secret keys associated to nodes along the path from their leaf to the root.\r\nWhen a user wants to update their key material they have to change $ \\log(N) $ many keys.\r\nThis requires uploading $ \\log(N) $ many ciphertexts to communicate the new keys to the rest of the group members in a way that respects the tree structure.\r\n\r\nIn this thesis we study how much communication between group members is required in order to add and remove users from a group as well as in order to provide PCS when we consider CGKAs built using standard cryptographic primitives like pseudo-random functions and public-key encryption. Furthermore, we also consider the case of MLS and provide the first lower bound showing that its communication complexity is much worse than previously believed, i.e., it is very far from $ \\log(N) $.\r\nFinally, we also propose a variant of MLS which provably achieves the same security properties with a much lower communication cost."}],"_id":"22664","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_place":"publisher","year":"2026","date_updated":"2026-10-16T10:14:40Z","date_published":"2026-08-10T00:00:00Z","publication_status":"published","article_processing_charge":"No","oa":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"supervisor":[{"orcid":"0000-0002-9139-1654","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z","full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-22664"},{"oa_version":"Published Version","day":"08","title":"Trustworthy machine learning in high dimensions","page":"446","acknowledgement":"This project was partially supported by the 2019 Lopez-Loreta prize,\r\nthe European Union (ERC, INF2\r\n, project number 101161364), the Austrian Science Fund\r\n(FWF) 10.55776/COE12, and a Google PhD fellowship in machine intelligence. Furthermore,\r\nthe candidate acknowledges the support from the Scientific Service Units of the Institute of\r\nScience and Technology Austria through resources provided by Scientific Computing.","publication_identifier":{"isbn":["978-3-99078-091-6"],"issn":["2663-337X"]},"doi":"10.15479/AT-ISTA-22857","department":[{"_id":"GradSch"},{"_id":"MaMo"}],"file":[{"access_level":"closed","date_created":"2026-09-08T13:28:38Z","file_id":"22859","file_name":"Thesis copy.zip","date_updated":"2026-09-08T13:28:38Z","relation":"source_file","file_size":99154325,"creator":"sbombari","content_type":"application/zip","checksum":"8eab99d6dc6e4476826bdfc7c00fdebb"},{"date_created":"2026-09-10T10:03:48Z","access_level":"open_access","file_id":"22898","date_updated":"2026-09-10T10:03:48Z","relation":"main_file","file_size":12856211,"file_name":"2026_Bombari_Simone_Thesis.pdf","success":1,"creator":"sbombari","checksum":"007033bafe4622ff4c2e758301354df1","content_type":"application/pdf"}],"type":"dissertation","has_accepted_license":"1","language":[{"iso":"eng"}],"date_created":"2026-09-08T13:40:08Z","alternative_title":["ISTA Thesis"],"supplementarymaterial":"no","publisher":"Institute of Science and Technology Austria","keyword":["machine learning","high-dimensional statistics","deep learning theory","privacy","memorization","robustness"],"status":"public","file_date_updated":"2026-09-10T10:03:48Z","ddc":["519"],"degree_awarded":"PhD","corr_author":"1","month":"09","doi_confirm":"1","citation":{"ama":"Bombari S. Trustworthy machine learning in high dimensions. 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22857\">10.15479/AT-ISTA-22857</a>","apa":"Bombari, S. (2026). <i>Trustworthy machine learning in high dimensions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-22857\">https://doi.org/10.15479/AT-ISTA-22857</a>","chicago":"Bombari, Simone. “Trustworthy Machine Learning in High Dimensions.” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-22857\">https://doi.org/10.15479/AT-ISTA-22857</a>.","ista":"Bombari S. 2026. Trustworthy machine learning in high dimensions. Institute of Science and Technology Austria.","mla":"Bombari, Simone. <i>Trustworthy Machine Learning in High Dimensions</i>. Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-22857\">10.15479/AT-ISTA-22857</a>.","short":"S. Bombari, Trustworthy Machine Learning in High Dimensions, Institute of Science and Technology Austria, 2026.","ieee":"S. Bombari, “Trustworthy machine learning in high dimensions,” Institute of Science and Technology Austria, 2026."},"abstract":[{"lang":"eng","text":"Artificial intelligence and machine learning have undergone an unprecedented evolution in the past decade, motivating a research effort toward a theory able to capture the qualitative behavior of large-scale neural systems. A central puzzle has been the clear benefit of scaling architecture size and overfitting the training set in supervised learning tasks. This evidence, in apparent contradiction with classical statistical learning theory, pushed researchers to develop a new theory capturing the interplay between the algorithmic and architectural bias of training and the specific target function, differently from previous methods rooted in uniform stability.\r\nThis approach has enabled a grounded understanding of novel learning regimes, typically through formal limits where the number of training samples $n$, data dimensions $d$, and model parameters $p$ grow to infinity at different rates. \\\\\r\nIn this thesis, we follow this approach, focusing on the trustworthiness of high-dimensional models: properties that are difficult to control during training or deployment and often emerge under unpredictable or adversarial conditions. In such settings, it is crucial to formally ensure a priori the reliability of machine learning systems.\r\nFirst, we study data memorization, both as label fitting and as the storage of private information about training samples in trained parameters. We prove that $p = \\Omega(n)$ parameters are sufficient for a deep neural network to memorize a generic set of labels, and for a model to memorize spurious features across training data. We then give evidence that $p = \\Omega(dn)$ parameters are instead necessary for an adversary to reconstruct the full training set from the trained parameters.\r\nSecond, we study robustness, both to adversarial perturbations and to distribution shift. We first prove that $p = \\Omega(dn)$ parameters can be sufficient for a class of neural networks to overfit the training data while guaranteeing robustness to adversarial perturbations. Then, we focus on spurious correlations learning in high-dimensional regression, studying the effect of the ridge regularization parameter in the proportional regime $n = \\Theta(d)$, and connecting it via an equivalence argument to the role of over-parameterization $p = \\Omega(n)$ in neural networks. We also investigate the architectural bias of attention-based networks, showing that they are sensitive to the replacement of individual words in an embedded sentence, allowing them to generalize on sentences where the contextual meaning depends on one or few words.\r\nFinally, we study differentially private optimization in high-dimensional regimes. We prove that standard private gradient methods do not suffer in the over-parameterized regime $p = \\Omega(n)$, challenging the current wisdom based on stability-derived generalization bounds. We then consider linear regression in the proportional regime $n = \\Theta(d)$, showing that standard private gradient descent can achieve optimal rates under appropriate hyper-parameter scaling, such as sufficiently small gradient clipping constants, whose role is still debated in practice."}],"author":[{"first_name":"Simone","full_name":"Bombari, Simone","last_name":"Bombari","id":"ca726dda-de17-11ea-bc14-f9da834f63aa"}],"related_material":{"record":[{"id":"12537","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"21324","status":"public"},{"status":"public","id":"22894","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"19627"},{"relation":"part_of_dissertation","id":"12859","status":"public"},{"status":"public","id":"18973","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"18972"}]},"researchdata_availability":"no","year":"2026","OA_place":"publisher","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"22857","date_published":"2026-09-08T00:00:00Z","das_tickbox":"0","date_updated":"2026-10-16T10:42:36Z","publication_status":"published","acknowledged_ssus":[{"_id":"ScienComp"}],"project":[{"name":"Trustworthy Deep Learning Theory: Private Over-Parameterized Models and Robust LLMs","_id":"92099302-16d5-11f0-9cad-f9a785f54fbd"},{"grant_number":"101161364","_id":"911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf","name":"Inference in High Dimensions: Light-speed Algorithms and Information Limits"},{"name":"Bilateral Artificial Intelligence (Mondelli)","grant_number":"COE12","_id":"74caaef7-b034-11f1-8f2d-e0e993bb422e"}],"article_processing_charge":"No","oa":1,"fulldoi":"https://doi.org/10.15479/AT-ISTA-22857","supervisor":[{"first_name":"Marco","last_name":"Mondelli","full_name":"Mondelli, Marco","orcid":"0000-0002-3242-7020","id":"27EB676C-8706-11E9-9510-7717E6697425"}]},{"file":[{"content_type":"application/pdf","checksum":"05517674168a275c70f18e964ce33d8b","creator":"dernst","success":1,"file_name":"2026_NatureComm_Machnik.pdf","file_size":2345578,"date_updated":"2026-10-07T09:50:18Z","relation":"main_file","file_id":"23070","date_created":"2026-10-07T09:50:18Z","access_level":"open_access"}],"department":[{"_id":"MaRo"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","doi":"10.1038/s41467-026-76877-7","language":[{"iso":"eng"}],"has_accepted_license":"1","type":"journal_article","supplementarymaterial":"no","date_created":"2026-10-04T22:01:53Z","oa_version":"Published Version","title":"Causal inference for multiple risk factors and diseases from genomics data","day":"25","publication_identifier":{"eissn":["2041-1723"]},"acknowledgement":"We thank Zoltan Kutalik andmembers of the Robinson group at ISTA for\r\ntheir comments, which improved this manuscript. We would like to\r\nacknowledge the participants and investigators of the UK Biobank study.\r\nHigh-performance computing was supported by the Scientific Service\r\nUnits (SSU) of IST Austria through resources provided by Scientific\r\nComputing (SciComp). This work was funded by a research collaboration agreement between\r\nBoehringer Ingelheim and the research group of MRR at the Institute of\r\nScience and Technology Austria. Additional funding was also provided\r\nby an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core\r\nfunding from the Institute of Science and Technology Austria. MB was\r\nfunded by the National Science Center Poland grant SONATINA UMO-\r\n2021/40/C/NZ2/00218.","month":"08","corr_author":"1","intvolume":"        17","scopus_import":"1","citation":{"ama":"Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. Causal inference for multiple risk factors and diseases from genomics data. <i>Nature Communications</i>. 2026;17. doi:<a href=\"https://doi.org/10.1038/s41467-026-76877-7\">10.1038/s41467-026-76877-7</a>","apa":"Machnik, N. N., Mahmoudi, S. M., Borczyk, M., Krätschmer, I., Bauer, M. J., &#38; Robinson, M. R. (2026). Causal inference for multiple risk factors and diseases from genomics data. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-026-76877-7\">https://doi.org/10.1038/s41467-026-76877-7</a>","chicago":"Machnik, Nick N, Seyed Mahdi Mahmoudi, Malgorzata Borczyk, Ilse Krätschmer, Markus J. Bauer, and Matthew Richard Robinson. “Causal Inference for Multiple Risk Factors and Diseases from Genomics Data.” <i>Nature Communications</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s41467-026-76877-7\">https://doi.org/10.1038/s41467-026-76877-7</a>.","ista":"Machnik NN, Mahmoudi SM, Borczyk M, Krätschmer I, Bauer MJ, Robinson MR. 2026. Causal inference for multiple risk factors and diseases from genomics data. Nature Communications. 17, 10153.","mla":"Machnik, Nick N., et al. “Causal Inference for Multiple Risk Factors and Diseases from Genomics Data.” <i>Nature Communications</i>, vol. 17, 10153, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s41467-026-76877-7\">10.1038/s41467-026-76877-7</a>.","short":"N.N. Machnik, S.M. Mahmoudi, M. Borczyk, I. Krätschmer, M.J. Bauer, M.R. Robinson, Nature Communications 17 (2026).","ieee":"N. N. Machnik, S. M. Mahmoudi, M. Borczyk, I. Krätschmer, M. J. Bauer, and M. R. Robinson, “Causal inference for multiple risk factors and diseases from genomics data,” <i>Nature Communications</i>, vol. 17. Springer Nature, 2026."},"publisher":"Springer Nature","article_number":"10153 ","file_date_updated":"2026-10-07T09:50:18Z","status":"public","ddc":["570"],"dataavailabilitystatement":"This project uses the UK Biobank data under project number 35520.\r\nUK Biobank genotypic and phenotypic data is available through a\r\nformal request at (http://www.ukbiobank.ac.uk). All of the data generated\r\nin this study are provided in the Source Data file. Source data\r\nare provided with this paper. The CI-GWAS code is fully open source and available at https://github.\r\ncom/medical-genomics-group/ci-gwasand has been archived on\r\nZenodo52. The scripts used to execute the model are available at\r\nhttps://github.com/medical-genomics-group/ci-gwas. R version 4.2.1 is\r\navailable at https://www.r-project.org/. Plink version 1.9 is available at\r\nhttps://www.cog-genomics.org/plink/1.9/.","date_updated":"2026-10-16T11:01:16Z","OA_type":"gold","das_tickbox":"1","date_published":"2026-08-25T00:00:00Z","publication_status":"published","publication":"Nature Communications","quality_controlled":"1","abstract":[{"text":"Mendelian randomization, the standard instrument variable causal-inference approach for genomics, can be severely biased by inadequate selection of appropriate instrument variables and horizontal pleiotropy. We introduce Causal Inference GWAS, a graphical approach that selects genetic instruments from summary statistics controlling for linkage and pleiotropy, accommodates rare variants and binary outcomes, distinguishes direct from indirect risk factors in high dimensions, and flags latent confounding. Applied to 9 risk factors, 4 metabolic disease outcomes, and 8.4M variants across 458,747 UK Biobank individuals, our method runs in 20 minutes, identifying only 696 genome-wide valid instruments. We replicate nearly all previously reported risk factor-outcome paths, but find that most are indistinguishable from unmeasured confounding. This suggests robust biobank causal inference will require longitudinal and family data to resolve temporal precedence from reverse causation. Our approach offers a principled first step toward screening genuine causal signal from phenotypic correlation in biobank data.","lang":"eng"}],"related_material":{"record":[{"id":"18648","status":"public","relation":"earlier_version"}]},"author":[{"id":"3591A0AA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6617-9742","full_name":"Machnik, Nick N","last_name":"Machnik","first_name":"Nick N"},{"id":"b9f6d5ef-7774-11eb-a47f-df2c75c02ee7","first_name":"Seyed Mahdi","full_name":"Mahmoudi, Seyed Mahdi","last_name":"Mahmoudi"},{"full_name":"Borczyk, Malgorzata","last_name":"Borczyk","first_name":"Malgorzata"},{"id":"30d4014e-7753-11eb-b44b-db6d61112e73","orcid":"0000-0002-5636-9259","full_name":"Krätschmer, Ilse","last_name":"Krätschmer","first_name":"Ilse"},{"full_name":"Bauer, Markus J.","last_name":"Bauer","first_name":"Markus J."},{"first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"}],"article_type":"original","OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","researchdata_availability":"yes","DOAJ_listed":"1","_id":"23043","article_processing_charge":"Yes","oa":1,"volume":17,"fulldoi":"https://doi.org/10.1038/s41467-026-76877-7","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"acknowledged_ssus":[{"_id":"ScienComp"}]},{"publication_status":"published","dataavailabilitystatement":"The reduced 1D NIRSpec/G395M spectra, the MIRI LRS 1D extraction, and the MIRI MRS 1D extraction used in this work are publicly available on Zenodo at DOI: 10.5281/zenodo.21539999.\r\nFacilities: JWST - James Webb Space Telescope, IRAM:NOEMA. -\r\nSoftware: GalfitS (R. Li et al. 2026), LMFIT (M. Newville et al. 2014), grizli (G. Brammer & J. Matharu 2021), msaexp (G. Brammer 2023)","OA_type":"gold","date_updated":"2026-10-19T06:48:25Z","das_tickbox":"1","date_published":"2026-10-10T00:00:00Z","external_id":{"arxiv":["2602.12325"]},"_id":"23152","DOAJ_listed":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","researchdata_availability":"yes","year":"2026","author":[{"last_name":"Fei","full_name":"Fei, Qinyue","first_name":"Qinyue"},{"full_name":"Fujimoto, Seiji","last_name":"Fujimoto","first_name":"Seiji"},{"last_name":"Brammer","full_name":"Brammer, Gabriel","first_name":"Gabriel"},{"first_name":"Ruancun","full_name":"Li, Ruancun","last_name":"Li"},{"first_name":"Luis C.","full_name":"Ho, Luis C.","last_name":"Ho"},{"first_name":"Volker","full_name":"Bromm, Volker","last_name":"Bromm"},{"last_name":"Álvarez-Márquez","full_name":"Álvarez-Márquez, Javier","first_name":"Javier"},{"first_name":"Yoshihisa","last_name":"Asada","full_name":"Asada, Yoshihisa"},{"full_name":"Barro, Guillermo","last_name":"Barro","first_name":"Guillermo"},{"full_name":"Colina, Luis","last_name":"Colina","first_name":"Luis"},{"first_name":"Pratika","last_name":"Dayal","full_name":"Dayal, Pratika"},{"first_name":"Steven L.","full_name":"Finkelstein, Steven L.","last_name":"Finkelstein"},{"first_name":"Johan P.U.","full_name":"Fynbo, Johan P.U.","last_name":"Fynbo"},{"full_name":"Ginolfi, Michele","last_name":"Ginolfi","first_name":"Michele"},{"last_name":"Inayoshi","full_name":"Inayoshi, Kohei","first_name":"Kohei"},{"full_name":"Kokorev, Vasily","last_name":"Kokorev","first_name":"Vasily"},{"last_name":"Leung","full_name":"Leung, Gene C.K.","first_name":"Gene C.K."},{"orcid":"0000-0003-2871-127X","id":"7439a258-f3c0-11ec-9501-9df22fe06720","first_name":"Jorryt J","full_name":"Matthee, Jorryt J","last_name":"Matthee"},{"first_name":"Romain A.","last_name":"Meyer","full_name":"Meyer, Romain A."},{"last_name":"Naidu","full_name":"Naidu, Rohan P.","first_name":"Rohan P."},{"last_name":"Onoue","full_name":"Onoue, Masafusa","first_name":"Masafusa"},{"last_name":"Pérez-González","full_name":"Pérez-González, Pablo G.","first_name":"Pablo G."},{"full_name":"Steinhardt, Charles L.","last_name":"Steinhardt","first_name":"Charles L."},{"first_name":"Francesco","last_name":"Valentino","full_name":"Valentino, Francesco"},{"first_name":"Fabian","last_name":"Walter","full_name":"Walter, Fabian"},{"last_name":"Xiao","full_name":"Xiao, Mengyuan","first_name":"Mengyuan"},{"last_name":"Zhang","full_name":"Zhang, Haowen","first_name":"Haowen"}],"article_type":"original","quality_controlled":"1","publication":"The Astrophysical Journal","abstract":[{"lang":"eng","text":"We present a panchromatic optical-millimeter characterization of GNz7q, a recently identified X-ray-weak,\r\nrapidly growing red quasar embedded within a dusty starburst galaxy at z = 7.1899, using the full suite of JWST/\r\nNIRCam, NIRSpec, Mid-Infrared Instrument (MIRI), and archival NOEMA observations. Our deep NIRSpec/\r\nG395M spectroscopy reveals unambiguous broad Balmer emission (FWHM = 2221 ± 20 km s\r\n−1\r\n), confirming a\r\nsuper-Eddington accreting black hole (BH) (λEdd = 2.7 ± 0.4) with a mass of\r\nlog(MBH/M ) = 7.55 ± 0.34,\r\nusing accretion-rate-corrected BH mass estimators. After subtracting the point source, we robustly detect stellar\r\nemission from the host galaxy across multiple NIRCam and MIRI filters. Our joint morphological-spectral\r\nanalysis yields a stellar mass of = ± * log(M /M ) 10.5 0.4\r\nand an intense star formation rate of\r\nSFR = 330 ± 97 M⊙ yr−1\r\n, confirming the host as a massive, dusty starburst galaxy. We find that GNz7q lies\r\non the local MBH–M* relation (MBH/M* ≃ 0.001) and is well positioned to evolve into the locus of massive Sloan\r\nDigital Sky Survey (SDSS) quasars with\r\nlog(MBH/M ) 9\r\nand M* ≈ 1011 M⊙ at z ∼ 6, owing to its remarkably\r\nrapid growth in both the BH and its host galaxy. This stands in stark contrast to many recently reported JWST\r\nactive galactic nucleus populations at similar redshifts, including the little red dots, whose weak or undetected star\r\nformation makes it difficult for them to grow into the massive galaxies hosting SDSS-like quasars. These results\r\nsuggest that GNz7q marks a rare, pivotal phase of early BH–galaxy coevolution, plausibly providing a crucial\r\ndirect pathway to the supermassive BH systems within the first billion years of the Universe."}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.3847/1538-4357/aea07b","volume":1010,"oa":1,"article_processing_charge":"Yes","supplementarymaterial":"yes","date_created":"2026-10-18T22:01:51Z","language":[{"iso":"eng"}],"has_accepted_license":"1","type":"journal_article","file":[{"creator":"dernst","success":1,"content_type":"application/pdf","checksum":"b319631e496b3f50fd32202bb19a5b99","access_level":"open_access","date_created":"2026-10-19T06:36:24Z","file_id":"23162","file_name":"2026_AstrophysicalJour_FeiQinyue.pdf","file_size":3985652,"date_updated":"2026-10-19T06:36:24Z","relation":"main_file"}],"department":[{"_id":"JoMa"}],"doi":"10.3847/1538-4357/aea07b","publication_identifier":{"eissn":["1538-4357"],"issn":["0004-637X"]},"acknowledgement":"We are grateful to Jinyi Yang and Feige Wang for their insightful discussions about the broad-line fitting. We are grateful to Zhiwei Pan and Yuming Fu for their discussions about the BH mass estimator.\r\n\r\nK.I. acknowledges support from the National Natural Science Foundation of China (12573015, W2532003), the Beijing Natural Science Foundation (IS25003), and the China Manned Space Program (CMS-CSST-2025-A09). LCH was supported by the National Science Foundation of China (12233001) and the China Manned Space Program (CMS-CSST-2025-A09). P.G.P.-G. acknowledges support from grant PID2022-139567NB-I00 funded by the Spanish Ministerio de Ciencia, Innovación y Universidades MCIU/AEI/10.13039/501100011033, FEDER Una manera de hacer Europa. J.A.-M. acknowledges support by grants PID2024-158856NA-I00 & PIB2021-127718NB-I00 from the Spanish Ministry of Science and Innovation/State Agency of Research MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe.”\r\n\r\nThis work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. The specific observations analyzed can be accessed via DOI: 10.17909/q19z-a348for the GNz7q observations and DOI: 10.17909/0akt-xx69for the MIRI images from the MEOW survey. These observations are associated with programs # 4762 and # 5407.","title":"Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2","day":"10","oa_version":"Published Version","scopus_import":"1","citation":{"mla":"Fei, Qinyue, et al. “Direct Pathway to the Early Supermassive Black Holes: A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.” <i>The Astrophysical Journal</i>, vol. 1010, no. 1, 86, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/aea07b\">10.3847/1538-4357/aea07b</a>.","short":"Q. Fei, S. Fujimoto, G. Brammer, R. Li, L.C. Ho, V. Bromm, J. Álvarez-Márquez, Y. Asada, G. Barro, L. Colina, P. Dayal, S.L. Finkelstein, J.P.U. Fynbo, M. Ginolfi, K. Inayoshi, V. Kokorev, G.C.K. Leung, J.J. Matthee, R.A. Meyer, R.P. Naidu, M. Onoue, P.G. Pérez-González, C.L. Steinhardt, F. Valentino, F. Walter, M. Xiao, H. Zhang, The Astrophysical Journal 1010 (2026).","ieee":"Q. Fei <i>et al.</i>, “Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2,” <i>The Astrophysical Journal</i>, vol. 1010, no. 1. IOP Publishing, 2026.","ama":"Fei Q, Fujimoto S, Brammer G, et al. Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. <i>The Astrophysical Journal</i>. 2026;1010(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/aea07b\">10.3847/1538-4357/aea07b</a>","chicago":"Fei, Qinyue, Seiji Fujimoto, Gabriel Brammer, Ruancun Li, Luis C. Ho, Volker Bromm, Javier Álvarez-Márquez, et al. “Direct Pathway to the Early Supermassive Black Holes: A Red Super-Eddington Quasar in a Massive Starburst Host at z = 7.2.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/aea07b\">https://doi.org/10.3847/1538-4357/aea07b</a>.","apa":"Fei, Q., Fujimoto, S., Brammer, G., Li, R., Ho, L. C., Bromm, V., … Zhang, H. (2026). Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/aea07b\">https://doi.org/10.3847/1538-4357/aea07b</a>","ista":"Fei Q, Fujimoto S, Brammer G, Li R, Ho LC, Bromm V, Álvarez-Márquez J, Asada Y, Barro G, Colina L, Dayal P, Finkelstein SL, Fynbo JPU, Ginolfi M, Inayoshi K, Kokorev V, Leung GCK, Matthee JJ, Meyer RA, Naidu RP, Onoue M, Pérez-González PG, Steinhardt CL, Valentino F, Walter F, Xiao M, Zhang H. 2026. Direct pathway to the early supermassive Black Holes: A red super-Eddington quasar in a massive starburst host at z = 7.2. The Astrophysical Journal. 1010(1), 86."},"PlanS_conform":"1","intvolume":"      1010","month":"10","ddc":["520"],"issue":"1","file_date_updated":"2026-10-19T06:36:24Z","article_number":"86","arxiv":1,"status":"public","publisher":"IOP Publishing"},{"file":[{"access_level":"open_access","date_created":"2026-10-19T06:19:39Z","file_id":"23161","file_name":"2026_CommunicationsBiology_Koshenov.pdf","relation":"main_file","file_size":1819866,"date_updated":"2026-10-19T06:19:39Z","creator":"dernst","success":1,"content_type":"application/pdf","checksum":"b90e60a625fcac8ef5d9ff968792d675"}],"doi":"10.1038/s42003-026-10581-6","department":[{"_id":"FISS"}],"language":[{"iso":"eng"}],"type":"journal_article","has_accepted_license":"1","supplementarymaterial":"yes","date_created":"2026-10-18T22:01:50Z","oa_version":"Published Version","title":"Presenilin-1 controls glycolysis and identity of pancreatic beta cells","day":"08","publication_identifier":{"eissn":["2399-3642"]},"acknowledgement":"We appreciate the technical assistance from Anna Schreilechner. We are grateful for support by all members of the animal facility team at IMB, University of Graz, as well as K. Zierler for assistance with animal licenses.  F.M, T.E., T.M., T.P., and W.F.G. are grateful to the Austrian Science Fund (FWF) for the excellence cluster 10.55776/COE14 (MetAGE), which was additionally supported by Land Styria, Stadt Graz, University of Graz and Medical University of Graz. This research was further supported by the FWF via the DKplus program 10.55776/W1226 (DK-MCD) to F.M., T.M., R.B.G., and W.F.G., 10.55776/P28529, 10.55776/I3716 (to R.M.), 10.55776/P28854, 10.55776/I3792, 10.55776/DOC130 (to T.M.), and 10.55776/I4319 (to. M.S.R.); the Austrian Research Promotion Agency (FFG) grants 864690 and 870454; the Integrative Metabolism Research Center Graz; the Austrian Infrastructure Program 2016/2017 (to T.M.), and 10.55776/COE7, 10.55776/COE17, 10.55776/FG12 and 10.55776/F73 (to R.B.G.); the Styrian Government; the City of Graz; and BioTechMed-Graz (flagship project) (to T.M.); the MEFO Graz (to W.F.G.). F.E.O., J.G. and Z.K. were doctoral fellows in the doctoral program Metabolic and Cardiovascular Disease (MCD) (FWF, 10.55776/W 1226) at the Medical University of Graz. S.v.A. and A.S. are thesis students in the excellence cluster 10.55776/COE14 (MetAGE, W.F.G.). M.H. was a fellow of the Molecular Medicine (MolMed) doctoral program at the Medical University of Graz supported by MEFO Graz. The SIM equipment is part of the Nikon Center of Excellence, Graz, and is supported by the Austrian infrastructure program 2013/ 2014, Nikon Austria Inc., and BioTechMed (to W.F.G.). Our thanks go to Shimadzu Austria for supporting this research through instrument access given in the Metabolomics and Bioprocess Analytics laboratory (TU Wien) (R.B.G.). For open access purposes, the authors have applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.” We thank the Medical University of Graz for financial support.","month":"10","intvolume":"         9","scopus_import":"1","citation":{"mla":"Koshenov, Zhanat, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” <i>Communications Biology</i>, vol. 9, 1315, Springer Nature, 2026, doi:<a href=\"https://doi.org/10.1038/s42003-026-10581-6\">10.1038/s42003-026-10581-6</a>.","short":"Z. Koshenov, S. Postic, G. Schoiswohl, S. Van Amsterdam, V. Hois-Zelinka, F.E. Oflaz, R. Rost, O. Tiapko, B. Gottschalk, M. Hirtl, O.G. Bachkoenig, A. Koshenova, Y.C. Erdogan, A. Sagintayev, A. Krnjic, J.U. Pfabe, S. Sarikas, B. Hochreiter, J. Gindlhuber, M. Schittmayer, J. Tadic, B. Ehall, F. Madeo, T. Madl, R. Malli, R. Birner-Gruenberger, T. Pieber, T. Eisenberg, M. Slak Rupnik, W.F. Graier, Communications Biology 9 (2026).","ieee":"Z. Koshenov <i>et al.</i>, “Presenilin-1 controls glycolysis and identity of pancreatic beta cells,” <i>Communications Biology</i>, vol. 9. Springer Nature, 2026.","apa":"Koshenov, Z., Postic, S., Schoiswohl, G., Van Amsterdam, S., Hois-Zelinka, V., Oflaz, F. E., … Graier, W. F. (2026). Presenilin-1 controls glycolysis and identity of pancreatic beta cells. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-026-10581-6\">https://doi.org/10.1038/s42003-026-10581-6</a>","ama":"Koshenov Z, Postic S, Schoiswohl G, et al. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. <i>Communications Biology</i>. 2026;9. doi:<a href=\"https://doi.org/10.1038/s42003-026-10581-6\">10.1038/s42003-026-10581-6</a>","chicago":"Koshenov, Zhanat, Sandra Postic, Gabriela Schoiswohl, Savina Van Amsterdam, Victoria Hois-Zelinka, Furkan E. Oflaz, Rene Rost, et al. “Presenilin-1 Controls Glycolysis and Identity of Pancreatic Beta Cells.” <i>Communications Biology</i>. Springer Nature, 2026. <a href=\"https://doi.org/10.1038/s42003-026-10581-6\">https://doi.org/10.1038/s42003-026-10581-6</a>.","ista":"Koshenov Z, Postic S, Schoiswohl G, Van Amsterdam S, Hois-Zelinka V, Oflaz FE, Rost R, Tiapko O, Gottschalk B, Hirtl M, Bachkoenig OG, Koshenova A, Erdogan YC, Sagintayev A, Krnjic A, Pfabe JU, Sarikas S, Hochreiter B, Gindlhuber J, Schittmayer M, Tadic J, Ehall B, Madeo F, Madl T, Malli R, Birner-Gruenberger R, Pieber T, Eisenberg T, Slak Rupnik M, Graier WF. 2026. Presenilin-1 controls glycolysis and identity of pancreatic beta cells. Communications Biology. 9, 1315."},"PlanS_conform":"1","publisher":"Springer Nature","file_date_updated":"2026-10-19T06:19:39Z","article_number":"1315","status":"public","ddc":["570"],"dataavailabilitystatement":"The data supporting the findings of this research can be obtained from the authors upon a reasonable request; please refer to the author’s contributions for details regarding specific datasets. Numerical source data underlying graphs in this article can be found in Supplementary data file. Supplementary Figs. and figure legends are included in the Supplementary file. The code used in this study is available from the authors on reasonable request.","OA_type":"gold","date_updated":"2026-10-19T06:23:26Z","das_tickbox":"1","date_published":"2026-10-08T00:00:00Z","publication_status":"published","pmid":1,"publication":"Communications Biology","quality_controlled":"1","abstract":[{"lang":"eng","text":"Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its role in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic beta cells, where it has been shown to be fundamental for the initial phase of glucose-induced insulin secretion. To gain mechanistic insight into beta cell autonomous function of PS1, we have examined various beta cell models and found that PS1 controls glycolytic flux of pancreatic beta cells by regulating sub-mitochondrial Ca2+ homeostasis. Transient knock down of PS1 yielded a glycolytic bottleneck at the step catalyzed by glyceraldehyde-3-phosphate dehydrogenase, resulting in defective glucose responsiveness. Moreover, we show that PS1 is needed for the preservation of beta cell identity, likely due to its role in glycolysis. Finally, we show that mouse islets from an in vivo model of AD mimic the defective glucose responsiveness seen in beta cells with transient PS1 knock down, while the identity loss and whole-body glucose homeostasis are not severely impacted, suggesting an adaptive response. Thus, the current work highlights beta cell autonomous role of PS1 and adds a layer of complexity in its impact on whole body metabolism."}],"article_type":"original","author":[{"last_name":"Koshenov","full_name":"Koshenov, Zhanat","first_name":"Zhanat"},{"full_name":"Postic, Sandra","last_name":"Postic","first_name":"Sandra"},{"first_name":"Gabriela","full_name":"Schoiswohl, Gabriela","last_name":"Schoiswohl"},{"first_name":"Savina","last_name":"Van Amsterdam","full_name":"Van Amsterdam, Savina"},{"full_name":"Hois-Zelinka, Victoria","last_name":"Hois-Zelinka","first_name":"Victoria"},{"last_name":"Oflaz","full_name":"Oflaz, Furkan E.","first_name":"Furkan E."},{"first_name":"Rene","full_name":"Rost, Rene","last_name":"Rost"},{"first_name":"Oleksandra","last_name":"Tiapko","full_name":"Tiapko, Oleksandra"},{"last_name":"Gottschalk","full_name":"Gottschalk, Benjamin","first_name":"Benjamin"},{"first_name":"Martin","last_name":"Hirtl","full_name":"Hirtl, Martin"},{"first_name":"Olaf G.","last_name":"Bachkoenig","full_name":"Bachkoenig, Olaf G."},{"first_name":"Aigerim","full_name":"Koshenova, Aigerim","last_name":"Koshenova"},{"full_name":"Erdogan, Yusuf C.","last_name":"Erdogan","first_name":"Yusuf C."},{"first_name":"Adlet","last_name":"Sagintayev","full_name":"Sagintayev, Adlet"},{"last_name":"Krnjic","full_name":"Krnjic, Anita","first_name":"Anita"},{"full_name":"Pfabe, Johannes U.","last_name":"Pfabe","first_name":"Johannes U."},{"id":"35F0286E-F248-11E8-B48F-1D18A9856A87","first_name":"Srdjan","last_name":"Sarikas","full_name":"Sarikas, Srdjan"},{"first_name":"Bernhard","full_name":"Hochreiter, Bernhard","last_name":"Hochreiter","id":"e6cab3de-17f6-11ed-9210-c1e42e045e9d"},{"first_name":"Juergen","full_name":"Gindlhuber, Juergen","last_name":"Gindlhuber"},{"full_name":"Schittmayer, Matthias","last_name":"Schittmayer","first_name":"Matthias"},{"last_name":"Tadic","full_name":"Tadic, Jelena","first_name":"Jelena"},{"first_name":"Barbara","last_name":"Ehall","full_name":"Ehall, Barbara"},{"first_name":"Frank","last_name":"Madeo","full_name":"Madeo, Frank"},{"first_name":"Tobias","last_name":"Madl","full_name":"Madl, Tobias"},{"last_name":"Malli","full_name":"Malli, Roland","first_name":"Roland"},{"first_name":"Ruth","last_name":"Birner-Gruenberger","full_name":"Birner-Gruenberger, Ruth"},{"first_name":"Thomas","last_name":"Pieber","full_name":"Pieber, Thomas"},{"last_name":"Eisenberg","full_name":"Eisenberg, Tobias","first_name":"Tobias"},{"last_name":"Slak Rupnik","full_name":"Slak Rupnik, Marjan","first_name":"Marjan"},{"first_name":"Wolfgang F.","full_name":"Graier, Wolfgang F.","last_name":"Graier"}],"OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","researchdata_availability":"upon request","year":"2026","external_id":{"pmid":["42387039"]},"DOAJ_listed":"1","_id":"23148","oa":1,"article_processing_charge":"Yes","volume":9,"fulldoi":"https://doi.org/10.1038/s42003-026-10581-6","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"}},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1093/mnras/stag1839","volume":552,"oa":1,"article_processing_charge":"Yes","_id":"23150","DOAJ_listed":"1","external_id":{"arxiv":["2511.04736"]},"researchdata_availability":"yes","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","article_type":"original","author":[{"first_name":"Matthew T.","full_name":"Scoggins, Matthew T.","last_name":"Scoggins"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","orcid":"0000-0003-3633-5403","full_name":"Haiman, Zoltán","last_name":"Haiman","first_name":"Zoltán"},{"last_name":"Pacucci","full_name":"Pacucci, Fabio","first_name":"Fabio"}],"abstract":[{"lang":"eng","text":"High-redshift supermassive black holes (SMBHs) have challenged our understanding of black hole formation and growth. The ‘heavy-seed’ pathway eases the problem with the progenitors of these SMBHs having birth masses up to∼105 M\u0003. Here, we investigate the possibility that a local dwarf galaxy, Leo I, harbours a heavy-seed descendant. Using Monte Carlo merger trees to generate the merger histories of 1000 dark matter haloes similar to the Milky Way (MW), we search for Leo- like satellite haloes and investigate the probability that the progenitors of these satellites formed a heavy seed. We derive the likelihood of such ‘heavy-seed survivors’ (HSSs) across various formation and survival criteria as well as Leo-similarity criteria. We find that the virial temperature for the onset of atomic cooling and rapid gas infall that yields heavy seeds, Tact , has the largest impact on HSS frequency. We find HSSs in a fraction 0.7 per cent, 18.1 per cent, and 96.5 per cent of MW-like haloes when Tact is set to 9000, 7000, and 5000 K, respectively. For the canonical atomic-cooling threshold ( Tact \u0002 8000 K), the HSS fraction is\u0003 1per cent , indicating that Leo I hosting a heavy-seed descendant is unlikely under well-motivated physical assumptions. Higher HSS fractions occur only under optimistic and currently unsubstantiated assumptions on Tact . Nevertheless, these results motivate future work that clarifies the possibility of heavy-seed BH formation in pristine haloes with nominal virial temperatures below 8000 K. This may motivate Leo I as a target for disentangling heavy seeds from other SMBH formation mechanisms."}],"quality_controlled":"1","publication":"Monthly Notices of the Royal Astronomical Society","publication_status":"published","das_tickbox":"1","date_published":"2026-11-01T00:00:00Z","dataavailabilitystatement":"The code used to analyse the merger trees and generate figures for this manuscript is available at this GitHub repository. All other data will be shared upon reasonable request to the corresponding author.","date_updated":"2026-10-19T07:05:55Z","OA_type":"gold","issue":"3","ddc":["520"],"status":"public","article_number":"stag1839","arxiv":1,"file_date_updated":"2026-10-19T07:05:43Z","publisher":"Oxford University Press","citation":{"ista":"Scoggins MT, Haiman Z, Pacucci F. 2026. Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. Monthly Notices of the Royal Astronomical Society. 552(3), stag1839.","apa":"Scoggins, M. T., Haiman, Z., &#38; Pacucci, F. (2026). Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stag1839\">https://doi.org/10.1093/mnras/stag1839</a>","chicago":"Scoggins, Matthew T., Zoltán Haiman, and Fabio Pacucci. “Heavy Black Hole Seed Survivors in Dwarf Galaxies: A Case Study of Leo I.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2026. <a href=\"https://doi.org/10.1093/mnras/stag1839\">https://doi.org/10.1093/mnras/stag1839</a>.","ama":"Scoggins MT, Haiman Z, Pacucci F. Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I. <i>Monthly Notices of the Royal Astronomical Society</i>. 2026;552(3). doi:<a href=\"https://doi.org/10.1093/mnras/stag1839\">10.1093/mnras/stag1839</a>","ieee":"M. T. Scoggins, Z. Haiman, and F. Pacucci, “Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 552, no. 3. Oxford University Press, 2026.","short":"M.T. Scoggins, Z. Haiman, F. Pacucci, Monthly Notices of the Royal Astronomical Society 552 (2026).","mla":"Scoggins, Matthew T., et al. “Heavy Black Hole Seed Survivors in Dwarf Galaxies: A Case Study of Leo I.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 552, no. 3, stag1839, Oxford University Press, 2026, doi:<a href=\"https://doi.org/10.1093/mnras/stag1839\">10.1093/mnras/stag1839</a>."},"scopus_import":"1","intvolume":"       552","month":"11","acknowledgement":"We thank the anonymous reviewer for feedback that helped clarify this manuscript. ZH acknowledges support from NSF grant AST-2006176. FP acknowledges support from the Black Hole Initiative at Harvard University, which is funded by grants from the John Templeton Foundation and the Gordon and Betty Moore Foundation. Merger tree generation and analysis were performed with NSF’s ACCESS allocations AST-120046 and AST-140041 on the Stampede3 resource. The freely available plotting library matplotlib (J. D. Hunter 2007) was used to construct the plots in this paper.","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]},"day":"01","title":"Heavy black hole seed survivors in dwarf galaxies: A case study of Leo I","oa_version":"Published Version","date_created":"2026-10-18T22:01:51Z","supplementarymaterial":"no","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"ZoHa"}],"doi":"10.1093/mnras/stag1839","file":[{"creator":"dernst","success":1,"checksum":"99a35f1305b7f1ed3813bcd51ba16724","content_type":"application/pdf","file_id":"23164","file_name":"2026_MonthNoticesRAS_Scoggins.pdf","date_updated":"2026-10-19T07:05:43Z","relation":"main_file","file_size":1450204,"access_level":"open_access","date_created":"2026-10-19T07:05:43Z"}]},{"department":[{"_id":"IlCa"}],"doi":"10.3847/1538-4357/ae9cb2","file":[{"relation":"main_file","date_updated":"2026-10-19T06:57:17Z","file_size":34494943,"file_name":"2026_AstrophysicalJour_Cunningham.pdf","file_id":"23163","access_level":"open_access","date_created":"2026-10-19T06:57:17Z","checksum":"a31da77f9197b832da52caf1417a87de","content_type":"application/pdf","success":1,"creator":"dernst"}],"date_created":"2026-10-18T22:01:51Z","supplementarymaterial":"yes","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"oa_version":"Published Version","acknowledgement":"We thank Jim Fuller, SR Kulkarni, David Charbonneau, Paul Duffell, Abigail Polin, Miranda Pikus, Tony Piro, Lars Bildsten, Eliot Quartert, and Rob Fesen for helpful discussions. This work was supported by NASA through the NASA Hubble Fellowship grant HST-HF2-51527.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.\r\n\r\nFacility: Gemini:Gillett (GMOS-N) - .\r\n\r\nSoftware: astropy (Astropy Collaboration et al. 2013, 2018), scipy (P. Virtanen et al. 2020), emcee (D. Foreman-Mackey et al. 2013), DRAGONS (K. Labrie et al. 2023), DS9 (W. A. Joye & E. Mandel 2003).","publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"day":"10","title":"Detection of knots in the type Iax supernova remnant Pa 30","corr_author":"1","month":"10","PlanS_conform":"1","citation":{"short":"T. Cunningham, I. Caiazzo, J.C. Raymond, S.J. Kenyon, The Astrophysical Journal 1010 (2026).","ieee":"T. Cunningham, I. Caiazzo, J. C. Raymond, and S. J. Kenyon, “Detection of knots in the type Iax supernova remnant Pa 30,” <i>The Astrophysical Journal</i>, vol. 1010, no. 1. IOP Publishing, 2026.","mla":"Cunningham, Tim, et al. “Detection of Knots in the Type Iax Supernova Remnant Pa 30.” <i>The Astrophysical Journal</i>, vol. 1010, no. 1, 28, IOP Publishing, 2026, doi:<a href=\"https://doi.org/10.3847/1538-4357/ae9cb2\">10.3847/1538-4357/ae9cb2</a>.","ista":"Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. 2026. Detection of knots in the type Iax supernova remnant Pa 30. The Astrophysical Journal. 1010(1), 28.","chicago":"Cunningham, Tim, Ilaria Caiazzo, John C. Raymond, and Scott J. Kenyon. “Detection of Knots in the Type Iax Supernova Remnant Pa 30.” <i>The Astrophysical Journal</i>. IOP Publishing, 2026. <a href=\"https://doi.org/10.3847/1538-4357/ae9cb2\">https://doi.org/10.3847/1538-4357/ae9cb2</a>.","apa":"Cunningham, T., Caiazzo, I., Raymond, J. C., &#38; Kenyon, S. J. (2026). Detection of knots in the type Iax supernova remnant Pa 30. <i>The Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ae9cb2\">https://doi.org/10.3847/1538-4357/ae9cb2</a>","ama":"Cunningham T, Caiazzo I, Raymond JC, Kenyon SJ. Detection of knots in the type Iax supernova remnant Pa 30. <i>The Astrophysical Journal</i>. 2026;1010(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ae9cb2\">10.3847/1538-4357/ae9cb2</a>"},"scopus_import":"1","intvolume":"      1010","publisher":"IOP Publishing","issue":"1","ddc":["520"],"status":"public","file_date_updated":"2026-10-19T06:57:17Z","article_number":"28","arxiv":1,"date_published":"2026-10-10T00:00:00Z","das_tickbox":"0","OA_type":"gold","date_updated":"2026-10-19T06:59:28Z","publication_status":"published","article_type":"original","author":[{"first_name":"Tim","last_name":"Cunningham","full_name":"Cunningham, Tim"},{"last_name":"Caiazzo","full_name":"Caiazzo, Ilaria","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","orcid":"0000-0002-4770-5388"},{"first_name":"John C.","full_name":"Raymond, John C.","last_name":"Raymond"},{"last_name":"Kenyon","full_name":"Kenyon, Scott J.","first_name":"Scott J."}],"abstract":[{"text":"We present deep, narrowband Gemini North/GMOS images of the Pa 30 nebula that reveal rich small-scale\r\nstructure in the ejecta filaments. In [S II], the number of detected filaments increases by about an order of\r\nmagnitude compared to previous studies. The imaging further reveals that the filaments are not smooth radial\r\nstreaks, but instead are composed of cascades of knots or clumps. The images in [O III] yield the first confirmation\r\nthat previously detected diffuse [O III] emission in fact originates from the same [S II] filaments. We measure a\r\nnebula center consistent with the position of the central star, indicating that the remnant has not received a large\r\ntransverse kick. The 3σ upper limit on the velocity of the stellar kick is ≲100 km s\r\n−1\r\n. Cross-sectional profiles of\r\nthe filaments in [S II] and [O III] show a central peak on top of a nebula background, the latter being likely due to\r\ndiffuse emission or unresolved filaments. The median [S II] width of 0.7 is slightly broader than the 0.50 seeing,\r\nproviding some evidence of partially resolved filaments and implying a characteristic knot diameter of ∼1016 cm.\r\nThe ≈1″ widths measured in [O III] are consistent with the poorer seeing of the oxygen images. The discovery of\r\nthis clumpy substructure provides a new observational constraint on models for the origin and evolution of the\r\nremarkable filamentary ejecta of Pa 30.","lang":"eng"}],"quality_controlled":"1","publication":"The Astrophysical Journal","DOAJ_listed":"1","_id":"23151","external_id":{"arxiv":["2610.06424"]},"researchdata_availability":"no","year":"2026","OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"article_processing_charge":"Yes","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.3847/1538-4357/ae9cb2","volume":1010},{"intvolume":"       314","citation":{"ista":"Bernert C, Derenthal U, Ortmann J, Wilsch FA. 2026. Integral points over number fields: a Clemens complex jigsaw puzzle. Mathematische Zeitschrift. 314(3), 37.","apa":"Bernert, C., Derenthal, U., Ortmann, J., &#38; Wilsch, F. A. (2026). Integral points over number fields: a Clemens complex jigsaw puzzle. <i>Mathematische Zeitschrift</i>. Springer. <a href=\"https://doi.org/10.1007/s00209-026-04140-2\">https://doi.org/10.1007/s00209-026-04140-2</a>","ama":"Bernert C, Derenthal U, Ortmann J, Wilsch FA. Integral points over number fields: a Clemens complex jigsaw puzzle. <i>Mathematische Zeitschrift</i>. 2026;314(3). doi:<a href=\"https://doi.org/10.1007/s00209-026-04140-2\">10.1007/s00209-026-04140-2</a>","chicago":"Bernert, Christian, Ulrich Derenthal, Judith Ortmann, and Florian Alexander Wilsch. “Integral Points over Number Fields: A Clemens Complex Jigsaw Puzzle.” <i>Mathematische Zeitschrift</i>. Springer, 2026. <a href=\"https://doi.org/10.1007/s00209-026-04140-2\">https://doi.org/10.1007/s00209-026-04140-2</a>.","ieee":"C. Bernert, U. Derenthal, J. Ortmann, and F. A. Wilsch, “Integral points over number fields: a Clemens complex jigsaw puzzle,” <i>Mathematische Zeitschrift</i>, vol. 314, no. 3. Springer, 2026.","short":"C. Bernert, U. Derenthal, J. Ortmann, F.A. Wilsch, Mathematische Zeitschrift 314 (2026).","mla":"Bernert, Christian, et al. “Integral Points over Number Fields: A Clemens Complex Jigsaw Puzzle.” <i>Mathematische Zeitschrift</i>, vol. 314, no. 3, 37, Springer, 2026, doi:<a href=\"https://doi.org/10.1007/s00209-026-04140-2\">10.1007/s00209-026-04140-2</a>."},"PlanS_conform":"1","scopus_import":"1","month":"11","status":"public","arxiv":1,"article_number":"37","file_date_updated":"2026-10-19T06:11:23Z","issue":"3","ddc":["510"],"publisher":"Springer","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"date_created":"2026-10-18T22:01:50Z","supplementarymaterial":"no","department":[{"_id":"TiBr"}],"doi":"10.1007/s00209-026-04140-2","file":[{"creator":"dernst","success":1,"checksum":"c2157633b4832a760336cd5d3f77b022","content_type":"application/pdf","file_id":"23160","file_name":"2026_MathemZeitschrift_Bernert.pdf","date_updated":"2026-10-19T06:11:23Z","file_size":593086,"relation":"main_file","date_created":"2026-10-19T06:11:23Z","access_level":"open_access"}],"day":"01","title":"Integral points over number fields: a Clemens complex jigsaw puzzle","acknowledgement":"Open Access funding enabled and organized by Projekt DEAL. We would like to thank the referee for their careful reading and helpful remarks that helped to improve this article. The first two authors were supported by the Deutsche Forschungsgemeinschaft (DFG) – 512730679 (RTG2965). The third author was partially supported by the Caroline Herschel Programme of Leibniz University Hannover. The fourth author was supported by the Deutsche Forschungsgemeinschaft (DFG) – 398436923 (RTG2491).","publication_identifier":{"issn":["0025-5874"],"eissn":["1432-1823"]},"oa_version":"Published Version","volume":314,"fulldoi":"https://doi.org/10.1007/s00209-026-04140-2","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"article_processing_charge":"Yes (via OA deal)","publication_status":"published","das_tickbox":"1","date_published":"2026-11-01T00:00:00Z","OA_type":"hybrid","date_updated":"2026-10-19T06:13:10Z","dataavailabilitystatement":"Our manuscript has no associated data.","researchdata_availability":"no","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","_id":"23149","external_id":{"arxiv":["2601.08774"]},"abstract":[{"text":"We prove an asymptotic formula for the number of integral points of bounded log anticanonical height on a singular quartic del Pezzo surface over arbitrary number fields, with respect to the largest admissible boundary divisor. The resulting Clemens complex is more complicated than usual, and leads to particularly interesting effective cone constants, associated with exponentially many polytopes whose volumes appear in the expected formula. Like a jigsaw puzzle, these polytopes fit together to one large polytope. The volume of this polytope appears in the asymptotic formula that we obtain using the universal torsor method via o-minimal structures.","lang":"eng"}],"quality_controlled":"1","publication":"Mathematische Zeitschrift","article_type":"original","author":[{"id":"aefba9fc-4694-11f0-b73e-8bd408e8f734","last_name":"Bernert","full_name":"Bernert, Christian","first_name":"Christian"},{"first_name":"Ulrich","last_name":"Derenthal","full_name":"Derenthal, Ulrich"},{"first_name":"Judith","last_name":"Ortmann","full_name":"Ortmann, Judith"},{"orcid":"0000-0001-7302-8256","id":"560601DA-8D36-11E9-A136-7AC1E5697425","first_name":"Florian Alexander","full_name":"Wilsch, Florian Alexander","last_name":"Wilsch"}]},{"arxiv":1,"article_number":"044017","status":"public","issue":"4","publisher":"American Physical Society","intvolume":"        26","scopus_import":"1","citation":{"mla":"Tjøtta, Maxim, et al. “Fast-Driving Spectroscopy of Current-Phase Relationships of Individual Josephson Elements.” <i>Physical Review Applied</i>, vol. 26, no. 4, 044017, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/d3gl-qntm\">10.1103/d3gl-qntm</a>.","ieee":"M. Tjøtta <i>et al.</i>, “Fast-driving spectroscopy of current-phase relationships of individual Josephson elements,” <i>Physical Review Applied</i>, vol. 26, no. 4. American Physical Society, 2026.","short":"M. Tjøtta, D.C. Shah, K. Modi, M. Valentini, R. Seoane Souto, G. Katsaros, J. Danon, Physical Review Applied 26 (2026).","ama":"Tjøtta M, Shah DC, Modi K, et al. Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. <i>Physical Review Applied</i>. 2026;26(4). doi:<a href=\"https://doi.org/10.1103/d3gl-qntm\">10.1103/d3gl-qntm</a>","chicago":"Tjøtta, Maxim, Devashish C Shah, Kanishk Modi, Marco Valentini, Rubén Seoane Souto, Georgios Katsaros, and Jeroen Danon. “Fast-Driving Spectroscopy of Current-Phase Relationships of Individual Josephson Elements.” <i>Physical Review Applied</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/d3gl-qntm\">https://doi.org/10.1103/d3gl-qntm</a>.","apa":"Tjøtta, M., Shah, D. C., Modi, K., Valentini, M., Seoane Souto, R., Katsaros, G., &#38; Danon, J. (2026). Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. <i>Physical Review Applied</i>. American Physical Society. <a href=\"https://doi.org/10.1103/d3gl-qntm\">https://doi.org/10.1103/d3gl-qntm</a>","ista":"Tjøtta M, Shah DC, Modi K, Valentini M, Seoane Souto R, Katsaros G, Danon J. 2026. Fast-driving spectroscopy of current-phase relationships of individual Josephson elements. Physical Review Applied. 26(4), 044017."},"month":"10","title":"Fast-driving spectroscopy of current-phase relationships of individual Josephson elements","day":"01","publication_identifier":{"eissn":["2331-7019"]},"acknowledgement":"The authors thank Afonso Oliveira, Stefano Calcaterra, Daniel Chrastina, and Giovanni Isella for providing the Ge/SiGe heterostructure. This work was supported by the Research Council of Norway through its Centers of Excellence funding scheme, Project No. 262633, “QuSpin,” the FWF Project with DOI:10.55776/PAT7682124, OeAD “ISTA Austria: ISTernship Summer Programme, Non-EU countries” (Ref. No.: MPC-2025-00945), the Spanish Comunidad de Madrid (CM) “Talento Program” (Project No. 2022-T1/IND-24070), and the Spanish Ministry of Science, Innovation, and Universities through Grants No. CEX2024-001445-S (Severo Ochoa Centres of Excellence program) and No. PID2022-140552NA-I00, funded by MCIN/AEI/10.13039/501100011033.","oa_version":"Preprint","language":[{"iso":"eng"}],"type":"journal_article","supplementarymaterial":"yes","date_created":"2026-10-18T22:01:52Z","doi":"10.1103/d3gl-qntm","department":[{"_id":"GeKa"},{"_id":"GradSch"}],"project":[{"_id":"5b9e579c-ab3d-11f0-914f-88754c5b5a3f","grant_number":"PAT 7682124","name":"Superconducting spin qubits in planar Ge"}],"fulldoi":"https://doi.org/10.1103/d3gl-qntm","volume":26,"oa":1,"article_processing_charge":"No","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2511.14313"}],"OA_place":"repository","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","researchdata_availability":"yes","external_id":{"arxiv":["2511.14313"]},"_id":"23156","publication":"Physical Review Applied","quality_controlled":"1","abstract":[{"lang":"eng","text":"Extracting the current-phase relationship (CPR) of a single superconducting junction is challenging in practice and traditionally involves embedding the junction in a larger superconducting circuit containing SQUIDs and/or resonators. Applying ac driving to the junction has proven to be a viable and less invasive way to extract information about the few lowest harmonics of the CPR, by locating the integer and fractional Shapiro steps in the 𝐼⁢𝑉-curve of the driven junction. Here, we present an alternative driving-based method that allows to extract the full harmonic content of a CPR in a relatively noninvasive way, by fitting the measured critical currents of the driven junction as a function of driving power. We test our method, both using numerical simulations and in experiments, and we show that it works accurately."}],"article_type":"original","author":[{"first_name":"Maxim","full_name":"Tjøtta, Maxim","last_name":"Tjøtta"},{"id":"de191434-4e7e-11ef-bf4b-9a056fc19fc3","orcid":"0009-0007-5829-7707","full_name":"Shah, Devashish C","last_name":"Shah","first_name":"Devashish C"},{"id":"f05345fd-900f-11f1-bfd8-8c0b6eadcc7f","first_name":"Kanishk","full_name":"Modi, Kanishk","last_name":"Modi"},{"last_name":"Valentini","full_name":"Valentini, Marco","first_name":"Marco","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425"},{"first_name":"Rubén","full_name":"Seoane Souto, Rubén","last_name":"Seoane Souto"},{"orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","first_name":"Georgios","full_name":"Katsaros, Georgios","last_name":"Katsaros"},{"last_name":"Danon","full_name":"Danon, Jeroen","first_name":"Jeroen"}],"publication_status":"published","dataavailabilitystatement":"The data that support the findings of this article are openly available at [10.5281/zenodo.22646275].","OA_type":"green","date_updated":"2026-10-19T07:25:01Z","das_tickbox":"1","date_published":"2026-10-01T00:00:00Z"},{"date_created":"2026-10-18T22:01:53Z","supplementarymaterial":"yes","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1103/p328-62sl","department":[{"_id":"GradSch"},{"_id":"ZoHa"}],"file":[{"date_updated":"2026-10-19T08:06:17Z","file_size":3535182,"relation":"main_file","file_name":"2026_PhysicalReviewD_Park.pdf","file_id":"23167","date_created":"2026-10-19T08:06:17Z","access_level":"open_access","content_type":"application/pdf","checksum":"764bd6512975216dd63655da64ceeb95","success":1,"creator":"dernst"}],"acknowledgement":"We acknowledge support by NASA Grants No. 80NSSC22K0822 and No. 80NSSC24K0440 (Z. H). V. A. V. acknowledges support through the David and Lucile Packard Foundation, National Science Foundation under No. PHY-2019786 (The NSF AI Institute for Artificial Intelligence and Fundamental Interactions, [63]), No. AST-2433718, No. AST-2407922 and No. AST-2406110, as well as an Aramont Fellowship for Emerging Science Research. J. D. acknowledges support by a joint Columbia/Flatiron Postdoctoral Fellowship. Research at the Flatiron Institute is supported by the Simons Foundation. This research was supported in part by the National Science Foundation under Grant No. NSF PHY-1748958 to the Kavli Institute for Theoretical Physics (KITP). This research has made use of NASA’s Astrophysics Data System. The authors acknowledge the Texas Advanced Computing Center (TACC) at The University of Texas at Austin for providing computational resources. V. A. V. acknowledges support through the David and Lucile Packard Foundation, National Science Foundation under No. AST-2433718, No. AST-2407922 and No. AST-2406110, as well as an Aramont Fellowship for Emerging Science Research. This work is supported by the National Science Foundation under Cooperative Agreement No. PHY-2019786 (The NSF AI Institute for Artificial Intelligence and Fundamental Interactions, [63]).","publication_identifier":{"eissn":["2470-0029"],"issn":["2470-0010"]},"day":"25","title":"Self-lensing flares from black hole binaries. V. Systematic searches in LSST","oa_version":"Published Version","citation":{"mla":"Park, Kevin S., et al. “Self-Lensing Flares from Black Hole Binaries. V. Systematic Searches in LSST.” <i>Physical Review D</i>, vol. 113, no. 4, 043055, American Physical Society, 2026, doi:<a href=\"https://doi.org/10.1103/p328-62sl\">10.1103/p328-62sl</a>.","ieee":"K. S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, and J. Davelaar, “Self-lensing flares from black hole binaries. V. Systematic searches in LSST,” <i>Physical Review D</i>, vol. 113, no. 4. American Physical Society, 2026.","short":"K.S. Park, Z. Haiman, C. Xin, T. Shen, A. Villar, J. Davelaar, Physical Review D 113 (2026).","ama":"Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. Self-lensing flares from black hole binaries. V. Systematic searches in LSST. <i>Physical Review D</i>. 2026;113(4). doi:<a href=\"https://doi.org/10.1103/p328-62sl\">10.1103/p328-62sl</a>","chicago":"Park, Kevin S, Zoltán Haiman, Chengcheng Xin, Tzuken Shen, Ashley Villar, and Jordy Davelaar. “Self-Lensing Flares from Black Hole Binaries. V. Systematic Searches in LSST.” <i>Physical Review D</i>. American Physical Society, 2026. <a href=\"https://doi.org/10.1103/p328-62sl\">https://doi.org/10.1103/p328-62sl</a>.","apa":"Park, K. S., Haiman, Z., Xin, C., Shen, T., Villar, A., &#38; Davelaar, J. (2026). Self-lensing flares from black hole binaries. V. Systematic searches in LSST. <i>Physical Review D</i>. American Physical Society. <a href=\"https://doi.org/10.1103/p328-62sl\">https://doi.org/10.1103/p328-62sl</a>","ista":"Park KS, Haiman Z, Xin C, Shen T, Villar A, Davelaar J. 2026. Self-lensing flares from black hole binaries. V. Systematic searches in LSST. Physical Review D. 113(4), 043055."},"PlanS_conform":"1","scopus_import":"1","intvolume":"       113","month":"02","issue":"4","ddc":["520"],"status":"public","file_date_updated":"2026-10-19T08:06:17Z","article_number":"043055","arxiv":1,"publisher":"American Physical Society","publication_status":"published","das_tickbox":"1","date_published":"2026-02-25T00:00:00Z","date_updated":"2026-10-19T08:08:21Z","OA_type":"hybrid","dataavailabilitystatement":"The data are not publicly available. The data are available from the authors upon reasonable request.","_id":"23159","external_id":{"arxiv":["2512.08427"]},"researchdata_availability":"no","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","author":[{"id":"c0a7603b-66e5-11f0-aaf9-b02edf8b2969","last_name":"Park","full_name":"Park, Kevin S","first_name":"Kevin S"},{"id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","orcid":"0000-0003-3633-5403","full_name":"Haiman, Zoltán","last_name":"Haiman","first_name":"Zoltán"},{"full_name":"Xin, Chengcheng","last_name":"Xin","first_name":"Chengcheng"},{"first_name":"Tzuken","full_name":"Shen, Tzuken","last_name":"Shen"},{"first_name":"Ashley","last_name":"Villar","full_name":"Villar, Ashley"},{"full_name":"Davelaar, Jordy","last_name":"Davelaar","first_name":"Jordy"}],"article_type":"original","abstract":[{"text":"The Vera C. Rubin Observatory has now seen first light, and over a 10 year duration, Legacy Survey of Space and Time (LSST) is projected to catalog tens of millions of quasars, many of which are expected to be associated with subparsec supermassive black hole binaries (SMBHBs). Out of these SMBHBs, up to thousands of relatively massive binary-quasars are expected to exhibit gravitational self-lensing flares (SLFs) that last for at least 20–30 days. We assess the effectiveness of the Lomb-Scargle (LS) periodogram and matched filters (MFs) as methods for systematic searches for these binaries, using toy-models of hydrodynamical, Doppler, and self-lensing variability from equal-mass, eccentric SMBHBs. We inject SLFs into random realizations of damped random walk (DRW) lightcurves, representing stochastic quasar variability, and compute the LS periodogram with and without the SLF. We find that periodograms of SLF+DRW light-curves do not have maximum peak heights that could not arise from DRW-only periodograms. On the other hand, the matched filter signal-to-noise ratio (SNR) can distinguish SLFs from noise even with LSST-like cadences and DRW noise. Furthermore, we develop a three-step procedure with matched filters, which can also recover injected binary parameters from these light-curves. We expect this method to be computationally efficient enough to be applicable to millions of quasar light-curves in LSST.","lang":"eng"}],"quality_controlled":"1","publication":"Physical Review D","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1103/p328-62sl","volume":113,"article_processing_charge":"Yes (in subscription journal)","oa":1},{"author":[{"last_name":"Hollom","full_name":"Hollom, Lawrence","first_name":"Lawrence"},{"first_name":"Lyuben","last_name":"Lichev","full_name":"Lichev, Lyuben","id":"9aa8388e-d003-11ee-8458-c4c1d7447977"},{"last_name":"Mond","full_name":"Mond, Adva","first_name":"Adva"},{"first_name":"Julien","last_name":"Portier","full_name":"Portier, Julien"},{"id":"1917d194-076e-11ed-97cd-837255f88785","first_name":"Yiting","last_name":"Wang","full_name":"Wang, Yiting"}],"article_type":"original","abstract":[{"lang":"eng","text":"In this work we establish several monotonicity and decomposition results in the framework of random regular graphs. Among other results, we\r\nshow that, for a wide range of parameters d1 ≤ d2, there exists a coupling of\r\nG(n,d1) and G(n,d2) satisfying that G(n,d1) ⊆ G(n,d2) with high probability, confirming a conjecture of Gao, Isaev and McKay in a new regime.\r\nOur contributions include new tools for analysing contiguity and total variation distance between random regular graph models, a novel procedure for\r\ngenerating unions of random edge-disjoint perfect matchings, and refined estimates of Gao’s bounds on the number of perfect matchings in random regular graphs. In addition, we make progress towards another conjecture of Isaev,\r\nMcKay, Southwell and Zhukovskii."}],"quality_controlled":"1","publication":"Annals of Applied Probability","_id":"23155","external_id":{"arxiv":["2505.22875"]},"researchdata_availability":"no","year":"2026","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","date_published":"2026-10-01T00:00:00Z","das_tickbox":"0","date_updated":"2026-10-19T07:39:17Z","OA_type":"hybrid","publication_status":"published","project":[{"grant_number":"101076777","_id":"bd95085b-d553-11ed-ba76-e55d3349be45","name":"Randomness and structure in combinatorics"},{"name":"THRESHOLDS IN SEMI-RANDOM PROCESSES AND GRAPH EMBEDDINGS","_id":"e19fef4c-1f3d-11f0-ac04-b8b1af6886d8","grant_number":"E624"}],"oa":1,"article_processing_charge":"Yes (in subscription journal)","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1214/26-AAP2345","volume":36,"oa_version":"Published Version","acknowledgement":"We are grateful to Béla Bollobás, to Matthew Kwan and to Fabio\r\nToninelli for their helpful comments and suggestions, and to Nicholas Wormald for useful\r\nremarks on a preliminary version of this work and pointing us towards the reference [29].\r\nThe authors would also like to thank several anonymous referees for many useful suggestions,\r\nincluding pointing out that Lemma 2.10 already appeared in [11].\r\nPart of this research was done during a visit of the fourth author to IST Austria. We thank\r\nIST Austria for its hospitality.\r\nFor open access purposes, the authors have applied a CC BY public copyright license to\r\nany author accepted manuscript version arising from this submission. L. Hollom was supported by the Internal Graduate Studentship of Trinity College, Cambridge.\r\nL. Lichev was supported by the Austrian Science Fund (FWF) grant No. 10.55776/ESP624.\r\nA. Mond was supported by UK Research and Innovation grant MR/W007320/2. Wang was\r\nsupported by the ERC Starting Grant “RANDSTRUCT” No. 101076777.","mathsc":["05C80"],"publication_identifier":{"eissn":["2168-8737"],"issn":["1050-5164"]},"day":"01","title":"Monotonicity and decompositions of random regular graphs","page":"4716-4738","doi":"10.1214/26-AAP2345","department":[{"_id":"MaKw"},{"_id":"GradSch"}],"file":[{"file_id":"23165","relation":"main_file","date_updated":"2026-10-19T07:33:58Z","file_size":320593,"file_name":"2026_AnnalsAppliedProbability_Hollom.pdf","date_created":"2026-10-19T07:33:58Z","access_level":"open_access","success":1,"creator":"dernst","content_type":"application/pdf","checksum":"46101e61d29cf40f0a204801d15a848f"}],"date_created":"2026-10-18T22:01:52Z","supplementarymaterial":"no","type":"journal_article","has_accepted_license":"1","language":[{"iso":"eng"}],"publisher":"Institute of Mathematical Statistics","keyword":["Random regular graphs","coupling","contiguity","total variation distance","decomposition"],"issue":"5","ddc":["500"],"status":"public","arxiv":1,"file_date_updated":"2026-10-19T07:33:58Z","month":"10","citation":{"short":"L. Hollom, L. Lichev, A. Mond, J. Portier, Y. Wang, Annals of Applied Probability 36 (2026) 4716–4738.","ieee":"L. Hollom, L. Lichev, A. Mond, J. Portier, and Y. Wang, “Monotonicity and decompositions of random regular graphs,” <i>Annals of Applied Probability</i>, vol. 36, no. 5. Institute of Mathematical Statistics, pp. 4716–4738, 2026.","mla":"Hollom, Lawrence, et al. “Monotonicity and Decompositions of Random Regular Graphs.” <i>Annals of Applied Probability</i>, vol. 36, no. 5, Institute of Mathematical Statistics, 2026, pp. 4716–38, doi:<a href=\"https://doi.org/10.1214/26-AAP2345\">10.1214/26-AAP2345</a>.","ista":"Hollom L, Lichev L, Mond A, Portier J, Wang Y. 2026. Monotonicity and decompositions of random regular graphs. Annals of Applied Probability. 36(5), 4716–4738.","chicago":"Hollom, Lawrence, Lyuben Lichev, Adva Mond, Julien Portier, and Yiting Wang. “Monotonicity and Decompositions of Random Regular Graphs.” <i>Annals of Applied Probability</i>. Institute of Mathematical Statistics, 2026. <a href=\"https://doi.org/10.1214/26-AAP2345\">https://doi.org/10.1214/26-AAP2345</a>.","apa":"Hollom, L., Lichev, L., Mond, A., Portier, J., &#38; Wang, Y. (2026). Monotonicity and decompositions of random regular graphs. <i>Annals of Applied Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/26-AAP2345\">https://doi.org/10.1214/26-AAP2345</a>","ama":"Hollom L, Lichev L, Mond A, Portier J, Wang Y. Monotonicity and decompositions of random regular graphs. <i>Annals of Applied Probability</i>. 2026;36(5):4716-4738. doi:<a href=\"https://doi.org/10.1214/26-AAP2345\">10.1214/26-AAP2345</a>"},"PlanS_conform":"1","scopus_import":"1","intvolume":"        36"},{"author":[{"first_name":"Jiaojiao","full_name":"Wu, Jiaojiao","last_name":"Wu"},{"first_name":"Valentina","last_name":"Corvaglia","full_name":"Corvaglia, Valentina"},{"full_name":"Chakrabortty, Tulika","last_name":"Chakrabortty","first_name":"Tulika"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","orcid":"0000-0001-5996-956X","last_name":"Mandal","full_name":"Mandal, Pradeep K","first_name":"Pradeep K"},{"first_name":"Ivan","last_name":"Huc","full_name":"Huc, Ivan"}],"article_type":"original","abstract":[{"text":"Single stranded helically folded aromatic oligoamides bearing anionic phosphonate side chains have been shown to bind to some DNA-binding proteins better than DNA itself. However, these DNA mimic foldamers have until now mainly consisted of a single repeat motif, like a poly(dA:dT) DNA duplex, and contained limited sequence information. Here, we introduce new monomers designed to display different chemical functionalities in the major groove of the DNA mimics. Four new Fmoc-protected amino acid monomers have been synthesized and incorporated into oligomers. Sixteen foldamer sequences were prepared on solid phase. Their conformation in solution and in the solid state and their conformational dynamics were investigated using NMR, circular dichroism, molecular modeling, and X-ray crystallography. The results show that three of four new monomers behaved as designed, and that their introduction enhances the conformational dynamics of the DNA mimic foldamers. In a fourth case, conformational behavior proved to be more complex than expected. The modified sequences retained an ability to bind to bacterial histone-like protein HU. These results showcase design strategies to manipulate large molecular biomimetics where not only side chains but also main chain components are varied. The new monomers pave the way to complex DNA mimic foldamer sequences targeting proteins that recognize sequence-selective DNA-binding proteins such as transcription factors or restriction enzymes.","lang":"eng"}],"publication":"Chemical Science","quality_controlled":"1","_id":"22012","DOAJ_listed":"1","external_id":{"pmid":["42388815"]},"year":"2026","researchdata_availability":"yes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","das_tickbox":"1","date_published":"2026-08-19T00:00:00Z","date_updated":"2026-10-19T08:35:08Z","dataavailabilitystatement":"CCDC 2514117, 2514118, 2286782 and 2478322 (compound 1, compound 1d, oligomer 5, and oligomer 6, respectively) contain the supplementary crystallographic data for this paper.54a–d \r\n\r\nThe supporting data have been provided as part of the supplementary information (SI). Supplementary information: SI figures, detailed experimental protocols, crystallographic studies, and characterisation of new compounds. See DOI: https://doi.org/10.1039/d6sc00798h.","OA_type":"gold","pmid":1,"publication_status":"published","oa":1,"article_processing_charge":"Yes","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"fulldoi":"https://doi.org/10.1039/d6sc00798h","volume":17,"oa_version":"Published Version","acknowledgement":"We acknowledge financial support from the European Research Council (ERC) under the European Union's Horizon Europe Framework Programme (grant agreement no. ERC-2021-ADG-320892) and from the China Scholarship Council (CSC, predoctoral fellowship to J. W.). We thank L. Allmendinger for assistance with NMR measurements, P. Mayer for his assistance in solving the crystal structures of 1 and 1d, L. Bodero for assistance with automated solid-phase synthesis, M. Rogovoi for providing monomer precursors, and M. Loos for the purification and analysis of compounds 15a–19a. We thank M. Soler-Lopez (ID23-1, ESRF, Grenoble) and I. Bento (EMBL P13, Petra III, DESY, Hamburg) for assistance during data collection at the synchrotron beamlines.","publication_identifier":{"issn":["2041-6520"],"eissn":["2041-6539"]},"day":"19","page":"15479–15489","title":"Tailoring the major groove of DNA mimic foldamers","doi":"10.1039/d6sc00798h","department":[{"_id":"LifeSc"}],"file":[{"checksum":"fee032060eb71cba73afa8e301b9ee94","content_type":"application/pdf","creator":"dernst","success":1,"file_name":"2026_ChemicalScience_Wu.pdf","date_updated":"2026-10-19T08:32:00Z","file_size":1361818,"relation":"main_file","file_id":"23169","access_level":"open_access","date_created":"2026-10-19T08:32:00Z"}],"date_created":"2026-06-16T08:04:15Z","supplementarymaterial":"yes","has_accepted_license":"1","type":"journal_article","language":[{"iso":"eng"}],"publisher":"Royal Society of Chemistry","issue":"32","ddc":["540"],"status":"public","file_date_updated":"2026-10-19T08:32:00Z","month":"08","citation":{"short":"J. Wu, V. Corvaglia, T. Chakrabortty, P.K. Mandal, I. Huc, Chemical Science 17 (2026) 15479–15489.","ieee":"J. Wu, V. Corvaglia, T. Chakrabortty, P. K. Mandal, and I. Huc, “Tailoring the major groove of DNA mimic foldamers,” <i>Chemical Science</i>, vol. 17, no. 32. Royal Society of Chemistry, pp. 15479–15489, 2026.","mla":"Wu, Jiaojiao, et al. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>, vol. 17, no. 32, Royal Society of Chemistry, 2026, pp. 15479–15489, doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>.","ista":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. 2026. Tailoring the major groove of DNA mimic foldamers. Chemical Science. 17(32), 15479–15489.","ama":"Wu J, Corvaglia V, Chakrabortty T, Mandal PK, Huc I. Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. 2026;17(32):15479–15489. doi:<a href=\"https://doi.org/10.1039/d6sc00798h\">10.1039/d6sc00798h</a>","apa":"Wu, J., Corvaglia, V., Chakrabortty, T., Mandal, P. K., &#38; Huc, I. (2026). Tailoring the major groove of DNA mimic foldamers. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>","chicago":"Wu, Jiaojiao, Valentina Corvaglia, Tulika Chakrabortty, Pradeep K Mandal, and Ivan Huc. “Tailoring the Major Groove of DNA Mimic Foldamers.” <i>Chemical Science</i>. Royal Society of Chemistry, 2026. <a href=\"https://doi.org/10.1039/d6sc00798h\">https://doi.org/10.1039/d6sc00798h</a>."},"PlanS_conform":"1","scopus_import":"1","intvolume":"        17"},{"oa":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"volume":65,"fulldoi":"https://doi.org/10.1007/s00526-026-03436-9","author":[{"first_name":"Morris","last_name":"Brooks","full_name":"Brooks, Morris","orcid":"0000-0002-6249-0928","id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425"},{"first_name":"David Johannes","full_name":"Mitrouskas, David Johannes","last_name":"Mitrouskas","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d"}],"article_type":"original","publication":"Calculus of Variations and Partial Differential Equations","quality_controlled":"1","abstract":[{"text":"We study the renormalized Nelson model in a semiclassical regime where the field becomes\r\nclassical while the particle remains quantum. The degree of classicality is measured by a\r\nsmall parameter ε << 1. In this scaling the particle evolves on microscopic times, whereas\r\nthe field exhibits nontrivial dynamics only on the macroscopic scale t = O(ε^−2). The natural\r\nsemiclassical model is the coupled Schrödinger–Klein–Gordon (SKG) system, which\r\nencodes the time-scale separation through an explicit ε-dependence. Based on this scale separation\r\nin SKG, we apply the adiabatic principle to derive a new PDE for the classical field,\r\nthe ε-free adiabatic Klein–Gordon (aKG) equation, where the field is driven by the instantaneous\r\nground state of the particle. Our main result is a norm approximation of the Nelson\r\ndynamics by the aKGsolution corrected by a quasi-free fluctuation dynamics around the classical\r\nfield, generated by a renormalized Bogoliubov–Nelson Hamiltonian. As a corollary, we\r\nobtain convergence of the reduced one-body densities for both subsystems, where the fluctuation\r\ncorrection vanishes, thereby justifying aKG as a semiclassical Born–Oppenheimer\r\ntype approximation of the renormalized Nelson model.","lang":"eng"}],"external_id":{"pmid":["42865432"],"arxiv":["2509.14226"]},"_id":"23153","OA_place":"publisher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","researchdata_availability":"no","OA_type":"hybrid","date_updated":"2026-10-19T07:55:13Z","dataavailabilitystatement":"No data are associated with this article.","date_published":"2026-10-01T00:00:00Z","das_tickbox":"1","publication_status":"published","pmid":1,"publisher":"Springer","ddc":["500"],"issue":"10","article_number":"270","file_date_updated":"2026-10-19T07:53:14Z","arxiv":1,"status":"public","month":"10","scopus_import":"1","PlanS_conform":"1","citation":{"chicago":"Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon Dynamics for the Renormalized Nelson Model.” <i>Calculus of Variations and Partial Differential Equations</i>. Springer, 2026. <a href=\"https://doi.org/10.1007/s00526-026-03436-9\">https://doi.org/10.1007/s00526-026-03436-9</a>.","ama":"Brooks M, Mitrouskas DJ. Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. <i>Calculus of Variations and Partial Differential Equations</i>. 2026;65(10). doi:<a href=\"https://doi.org/10.1007/s00526-026-03436-9\">10.1007/s00526-026-03436-9</a>","apa":"Brooks, M., &#38; Mitrouskas, D. J. (2026). Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. <i>Calculus of Variations and Partial Differential Equations</i>. Springer. <a href=\"https://doi.org/10.1007/s00526-026-03436-9\">https://doi.org/10.1007/s00526-026-03436-9</a>","ista":"Brooks M, Mitrouskas DJ. 2026. Adiabatic Klein–Gordon dynamics for the renormalized Nelson model. Calculus of Variations and Partial Differential Equations. 65(10), 270.","mla":"Brooks, Morris, and David Johannes Mitrouskas. “Adiabatic Klein–Gordon Dynamics for the Renormalized Nelson Model.” <i>Calculus of Variations and Partial Differential Equations</i>, vol. 65, no. 10, 270, Springer, 2026, doi:<a href=\"https://doi.org/10.1007/s00526-026-03436-9\">10.1007/s00526-026-03436-9</a>.","short":"M. Brooks, D.J. Mitrouskas, Calculus of Variations and Partial Differential Equations 65 (2026).","ieee":"M. Brooks and D. J. Mitrouskas, “Adiabatic Klein–Gordon dynamics for the renormalized Nelson model,” <i>Calculus of Variations and Partial Differential Equations</i>, vol. 65, no. 10. Springer, 2026."},"intvolume":"        65","oa_version":"Published Version","publication_identifier":{"issn":["0944-2669"],"eissn":["1432-0835"]},"acknowledgement":"Morris Brooks gratefully acknowledges support from the ERC Advanced Grant CLaQS, grant agreement No. 834782. Open access funding provided by University of Zurich.","mathsc":["81Q05"],"title":"Adiabatic Klein–Gordon dynamics for the renormalized Nelson model","day":"01","file":[{"checksum":"406bc9d144c35c9485d277c842d38c36","content_type":"application/pdf","creator":"dernst","success":1,"file_name":"2026_CalculusVariations_Brooks.pdf","file_size":905142,"relation":"main_file","date_updated":"2026-10-19T07:53:14Z","file_id":"23166","date_created":"2026-10-19T07:53:14Z","access_level":"open_access"}],"doi":"10.1007/s00526-026-03436-9","department":[{"_id":"RoSe"}],"supplementarymaterial":"yes","date_created":"2026-10-18T22:01:52Z","language":[{"iso":"eng"}],"has_accepted_license":"1","type":"journal_article"}]