[{"license":"https://creativecommons.org/licenses/by/4.0/","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":21,"type":"journal_article","abstract":[{"lang":"eng","text":"We show that matrix elements of functions of N × N Wigner matrices fluctuate on a scale of order N−1/2 and we identify the limiting fluctuation. Our result holds for any function f of the matrix that has bounded variation thus considerably relaxing the regularity requirement imposed in [7, 11]."}],"author":[{"orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös"},{"first_name":"Dominik J","last_name":"Schröder","id":"408ED176-F248-11E8-B48F-1D18A9856A87","full_name":"Schröder, Dominik J","orcid":"0000-0002-2904-1856"}],"_id":"1144","pubrep_id":"747","acknowledgement":"Partially supported by the IST Austria Excellence Scholarship.","month":"01","day":"02","publist_id":"6214","has_accepted_license":"1","department":[{"_id":"LaEr"}],"publication_status":"published","file":[{"file_size":440770,"date_updated":"2018-12-12T10:18:10Z","content_type":"application/pdf","access_level":"open_access","date_created":"2018-12-12T10:18:10Z","creator":"system","file_id":"5329","relation":"main_file","file_name":"IST-2017-747-v1+1_euclid.ecp.1483347665.pdf"}],"file_date_updated":"2018-12-12T10:18:10Z","oa":1,"article_number":"86","scopus_import":"1","fulldoi":"https://doi.org/10.1214/16-ECP38","article_processing_charge":"No","publication":"Electronic Communications in Probability","isi":1,"external_id":{"isi":["000396604900037"]},"title":"Fluctuations of functions of Wigner matrices","doi":"10.1214/16-ECP38","date_published":"2017-01-02T00:00:00Z","oa_version":"Published Version","date_created":"2018-12-11T11:50:23Z","project":[{"grant_number":"338804","call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems"}],"date_updated":"2026-07-29T13:46:19Z","ddc":["510"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publisher":"Institute of Mathematical Statistics","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","id":"6179","relation":"dissertation_contains"}]},"year":"2017","ec_funded":1,"quality_controlled":"1","status":"public","citation":{"short":"L. Erdös, D.J. Schröder, Electronic Communications in Probability 21 (2017).","chicago":"Erdös, László, and Dominik J Schröder. “Fluctuations of Functions of Wigner Matrices.” <i>Electronic Communications in Probability</i>. Institute of Mathematical Statistics, 2017. <a href=\"https://doi.org/10.1214/16-ECP38\">https://doi.org/10.1214/16-ECP38</a>.","mla":"Erdös, László, and Dominik J. Schröder. “Fluctuations of Functions of Wigner Matrices.” <i>Electronic Communications in Probability</i>, vol. 21, 86, Institute of Mathematical Statistics, 2017, doi:<a href=\"https://doi.org/10.1214/16-ECP38\">10.1214/16-ECP38</a>.","ieee":"L. Erdös and D. J. Schröder, “Fluctuations of functions of Wigner matrices,” <i>Electronic Communications in Probability</i>, vol. 21. Institute of Mathematical Statistics, 2017.","ama":"Erdös L, Schröder DJ. Fluctuations of functions of Wigner matrices. <i>Electronic Communications in Probability</i>. 2017;21. doi:<a href=\"https://doi.org/10.1214/16-ECP38\">10.1214/16-ECP38</a>","apa":"Erdös, L., &#38; Schröder, D. J. (2017). Fluctuations of functions of Wigner matrices. <i>Electronic Communications in Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/16-ECP38\">https://doi.org/10.1214/16-ECP38</a>","ista":"Erdös L, Schröder DJ. 2017. Fluctuations of functions of Wigner matrices. Electronic Communications in Probability. 21, 86."},"intvolume":"        21"},{"title":"Unified Hanani Tutte theorem","corr_author":"1","date_published":"2017-07-28T00:00:00Z","doi":"10.37236/6663","project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734"}],"date_created":"2018-12-11T11:48:32Z","oa_version":"Published Version","ddc":["000"],"date_updated":"2026-08-04T09:30:34Z","language":[{"iso":"eng"}],"publisher":"Electronic Journal of Combinatorics","year":"2017","status":"public","quality_controlled":"1","ec_funded":1,"citation":{"ista":"Fulek R, Kynčl J, Pálvölgyi D. 2017. Unified Hanani Tutte theorem. The Electronic Journal of Combinatorics. 24(3), P3.18.","mla":"Fulek, Radoslav, et al. “Unified Hanani Tutte Theorem.” <i>The Electronic Journal of Combinatorics</i>, vol. 24, no. 3, P3.18, Electronic Journal of Combinatorics, 2017, doi:<a href=\"https://doi.org/10.37236/6663\">10.37236/6663</a>.","ieee":"R. Fulek, J. Kynčl, and D. Pálvölgyi, “Unified Hanani Tutte theorem,” <i>The Electronic Journal of Combinatorics</i>, vol. 24, no. 3. Electronic Journal of Combinatorics, 2017.","chicago":"Fulek, Radoslav, Jan Kynčl, and Dömötör Pálvölgyi. “Unified Hanani Tutte Theorem.” <i>The Electronic Journal of Combinatorics</i>. Electronic Journal of Combinatorics, 2017. <a href=\"https://doi.org/10.37236/6663\">https://doi.org/10.37236/6663</a>.","short":"R. Fulek, J. Kynčl, D. Pálvölgyi, The Electronic Journal of Combinatorics 24 (2017).","apa":"Fulek, R., Kynčl, J., &#38; Pálvölgyi, D. (2017). Unified Hanani Tutte theorem. <i>The Electronic Journal of Combinatorics</i>. Electronic Journal of Combinatorics. <a href=\"https://doi.org/10.37236/6663\">https://doi.org/10.37236/6663</a>","ama":"Fulek R, Kynčl J, Pálvölgyi D. Unified Hanani Tutte theorem. <i>The Electronic Journal of Combinatorics</i>. 2017;24(3). doi:<a href=\"https://doi.org/10.37236/6663\">10.37236/6663</a>"},"intvolume":"        24","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":24,"publication_identifier":{"issn":["1077-8926"]},"type":"journal_article","abstract":[{"text":"We introduce a common generalization of the strong Hanani–Tutte theorem and the weak Hanani–Tutte theorem: if a graph G has a drawing D in the plane where every pair of independent edges crosses an even number of times, then G has a planar drawing preserving the rotation of each vertex whose incident edges cross each other evenly in D. The theorem is implicit in the proof of the strong Hanani–Tutte theorem by Pelsmajer, Schaefer and Štefankovič. We give a new, somewhat simpler proof.","lang":"eng"}],"author":[{"first_name":"Radoslav","last_name":"Fulek","orcid":"0000-0001-8485-1774","id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","full_name":"Fulek, Radoslav"},{"last_name":"Kynčl","first_name":"Jan","full_name":"Kynčl, Jan"},{"first_name":"Dömötör","last_name":"Pálvölgyi","full_name":"Pálvölgyi, Dömötör"}],"_id":"795","has_accepted_license":"1","publist_id":"6859","day":"28","month":"07","issue":"3","department":[{"_id":"UlWa"}],"publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:48:06Z","file":[{"file_id":"5853","relation":"main_file","file_name":"2017_ElectrCombi_Fulek.pdf","file_size":236944,"date_updated":"2020-07-14T12:48:06Z","access_level":"open_access","content_type":"application/pdf","date_created":"2019-01-18T14:04:08Z","creator":"dernst","checksum":"ef320cff0f062051e858f929be6a3581"}],"article_number":"P3.18","article_type":"original","fulldoi":"https://doi.org/10.37236/6663","scopus_import":"1","publication":"The Electronic Journal of Combinatorics","article_processing_charge":"No"},{"status":"public","quality_controlled":"1","year":"2017","intvolume":"         4","citation":{"ama":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. Ant queens increase their reproductive efforts after pathogen infection. <i>Royal Society Open Science</i>. 2017;4(7). doi:<a href=\"https://doi.org/10.1098/rsos.170547\">10.1098/rsos.170547</a>","apa":"Giehr, J., Grasse, A. V., Cremer, S., Heinze, J., &#38; Schrempf, A. (2017). Ant queens increase their reproductive efforts after pathogen infection. <i>Royal Society Open Science</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsos.170547\">https://doi.org/10.1098/rsos.170547</a>","short":"J. Giehr, A.V. Grasse, S. Cremer, J. Heinze, A. Schrempf, Royal Society Open Science 4 (2017).","chicago":"Giehr, Julia, Anna V Grasse, Sylvia Cremer, Jürgen Heinze, and Alexandra Schrempf. “Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” <i>Royal Society Open Science</i>. Royal Society, 2017. <a href=\"https://doi.org/10.1098/rsos.170547\">https://doi.org/10.1098/rsos.170547</a>.","ieee":"J. Giehr, A. V. Grasse, S. Cremer, J. Heinze, and A. Schrempf, “Ant queens increase their reproductive efforts after pathogen infection,” <i>Royal Society Open Science</i>, vol. 4, no. 7. Royal Society, 2017.","mla":"Giehr, Julia, et al. “Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” <i>Royal Society Open Science</i>, vol. 4, no. 7, 170547, Royal Society, 2017, doi:<a href=\"https://doi.org/10.1098/rsos.170547\">10.1098/rsos.170547</a>.","ista":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. 2017. Ant queens increase their reproductive efforts after pathogen infection. Royal Society Open Science. 4(7), 170547."},"ddc":["576","592"],"date_updated":"2026-08-12T06:25:39Z","date_created":"2018-12-11T11:49:10Z","oa_version":"Published Version","date_published":"2017-07-05T00:00:00Z","doi":"10.1098/rsos.170547","title":"Ant queens increase their reproductive efforts after pathogen infection","external_id":{"isi":["000406670000025"]},"related_material":{"record":[{"relation":"research_data","id":"9853","status":"public"}]},"language":[{"iso":"eng"}],"publisher":"Royal Society","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"issue":"7","publication_status":"published","department":[{"_id":"SyCr"}],"publist_id":"6527","has_accepted_license":"1","month":"07","day":"05","isi":1,"publication":"Royal Society Open Science","article_processing_charge":"No","fulldoi":"https://doi.org/10.1098/rsos.170547","scopus_import":"1","article_number":"170547","oa":1,"file":[{"relation":"main_file","file_name":"IST-2017-849-v1+1_2017_Grasse_Cremer_AntQueens.pdf","file_id":"4684","creator":"system","checksum":"351ae5e7a37e6e7d9295cd41146c4190","date_updated":"2020-07-14T12:48:15Z","file_size":530412,"access_level":"open_access","content_type":"application/pdf","date_created":"2018-12-12T10:08:24Z"}],"file_date_updated":"2020-07-14T12:48:15Z","volume":4,"publication_identifier":{"issn":["2054-5703"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"914","pubrep_id":"849","author":[{"full_name":"Giehr, Julia","first_name":"Julia","last_name":"Giehr"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","last_name":"Grasse","first_name":"Anna V"},{"orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","first_name":"Sylvia","last_name":"Cremer"},{"first_name":"Jürgen","last_name":"Heinze","full_name":"Heinze, Jürgen"},{"full_name":"Schrempf, Alexandra","last_name":"Schrempf","first_name":"Alexandra"}],"acknowledgement":"We thank two anonymous reviewers for helpful suggestions on the manuscript.","abstract":[{"text":"Infections with potentially lethal pathogens may negatively affect an individual’s lifespan and decrease its reproductive value. The terminal investment hypothesis predicts that individuals faced with a reduced survival should invest more into reproduction instead of maintenance and growth. Several studies suggest that individuals are indeed able to estimate their body condition and to increase their reproductive effort with approaching death, while other studies gave ambiguous results. We investigate whether queens of a perennial social insect (ant) are able to boost their reproduction following infection with an obligate killing pathogen. Social insect queens are special with regard to reproduction and aging, as they outlive conspecific non-reproductive workers. Moreover, in the ant Cardiocondyla obscurior, fecundity increases with queen age. However, it remained unclear whether this reflects negative reproductive senescence or terminal investment in response to approaching death. Here, we test whether queens of C. obscurior react to infection with the entomopathogenic fungus Metarhizium brunneum by an increased egg-laying rate. We show that a fungal infection triggers a reinforced investment in reproduction in queens. This adjustment of the reproductive rate by ant queens is consistent with predictions of the terminal investment hypothesis and is reported for the first time in a social insect.","lang":"eng"}],"type":"journal_article"},{"abstract":[{"lang":"eng","text":"Egg laying rates and infection loads of C. obscurior queens"}],"publisher":"The Royal Society","type":"research_data_reference","_id":"9853","author":[{"full_name":"Giehr, Julia","first_name":"Julia","last_name":"Giehr"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","last_name":"Grasse","first_name":"Anna V"},{"last_name":"Cremer","first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"},{"full_name":"Heinze, Jürgen","first_name":"Jürgen","last_name":"Heinze"},{"last_name":"Schrempf","first_name":"Alexandra","full_name":"Schrempf, Alexandra"}],"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"914"}]},"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_published":"2017-06-19T00:00:00Z","doi":"10.6084/m9.figshare.5117788.v1","title":"Raw data from ant queens increase their reproductive efforts after pathogen infection","date_updated":"2026-08-12T06:25:39Z","oa_version":"Published Version","date_created":"2021-08-10T06:57:57Z","citation":{"ista":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. 2017. Raw data from ant queens increase their reproductive efforts after pathogen infection, The Royal Society, <a href=\"https://doi.org/10.6084/m9.figshare.5117788.v1\">10.6084/m9.figshare.5117788.v1</a>.","short":"J. Giehr, A.V. Grasse, S. Cremer, J. Heinze, A. Schrempf, (2017).","chicago":"Giehr, Julia, Anna V Grasse, Sylvia Cremer, Jürgen Heinze, and Alexandra Schrempf. “Raw Data from Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” The Royal Society, 2017. <a href=\"https://doi.org/10.6084/m9.figshare.5117788.v1\">https://doi.org/10.6084/m9.figshare.5117788.v1</a>.","mla":"Giehr, Julia, et al. <i>Raw Data from Ant Queens Increase Their Reproductive Efforts after Pathogen Infection</i>. The Royal Society, 2017, doi:<a href=\"https://doi.org/10.6084/m9.figshare.5117788.v1\">10.6084/m9.figshare.5117788.v1</a>.","ieee":"J. Giehr, A. V. Grasse, S. Cremer, J. Heinze, and A. Schrempf, “Raw data from ant queens increase their reproductive efforts after pathogen infection.” The Royal Society, 2017.","ama":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. Raw data from ant queens increase their reproductive efforts after pathogen infection. 2017. doi:<a href=\"https://doi.org/10.6084/m9.figshare.5117788.v1\">10.6084/m9.figshare.5117788.v1</a>","apa":"Giehr, J., Grasse, A. V., Cremer, S., Heinze, J., &#38; Schrempf, A. (2017). Raw data from ant queens increase their reproductive efforts after pathogen infection. The Royal Society. <a href=\"https://doi.org/10.6084/m9.figshare.5117788.v1\">https://doi.org/10.6084/m9.figshare.5117788.v1</a>"},"oa":1,"article_processing_charge":"No","fulldoi":"https://doi.org/10.6084/m9.figshare.5117788.v1","main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.5117788.v1","open_access":"1"}],"year":"2017","day":"19","month":"06","status":"public","department":[{"_id":"SyCr"}]},{"abstract":[{"lang":"eng","text":"The role of natural selection in the evolution of adaptive phenotypes has undergone constant probing by evolutionary biologists, employing both theoretical and empirical approaches. As Darwin noted, natural selection can act together with other processes, including random changes in the frequencies of phenotypic differences that are not under strong selection, and changes in the environment, which may reflect evolutionary changes in the organisms themselves. As understanding of genetics developed after 1900, the new genetic discoveries were incorporated into evolutionary biology. The resulting general principles were summarized by Julian Huxley in his 1942 book Evolution: the modern synthesis. Here, we examine how recent advances in genetics, developmental biology and molecular biology, including epigenetics, relate to today's understanding of the evolution of adaptations. We illustrate how careful genetic studies have repeatedly shown that apparently puzzling results in a wide diversity of organisms involve processes that are consistent with neo-Darwinism. They do not support important roles in adaptation for processes such as directed mutation or the inheritance of acquired characters, and therefore no radical revision of our understanding of the mechanism of adaptive evolution is needed."}],"type":"journal_article","_id":"953","author":[{"full_name":"Charlesworth, Deborah","first_name":"Deborah","last_name":"Charlesworth"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"},{"full_name":"Charlesworth, Brian","first_name":"Brian","last_name":"Charlesworth"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":284,"article_number":"20162864","oa":1,"publication":"Proceedings of the Royal Society of London Series B Biological Sciences","isi":1,"article_processing_charge":"No","fulldoi":"https://doi.org/10.1098/rspb.2016.2864","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454256/","open_access":"1"}],"scopus_import":"1","publist_id":"6462","month":"05","day":"31","issue":"1855","department":[{"_id":"NiBa"}],"publication_status":"published","publisher":"Royal Society","language":[{"iso":"eng"}],"date_published":"2017-05-31T00:00:00Z","doi":"10.1098/rspb.2016.2864","title":"The sources of adaptive evolution","external_id":{"pmid":["28566483"],"isi":["000405148800021"]},"date_updated":"2026-08-12T06:26:59Z","pmid":1,"date_created":"2018-12-11T11:49:23Z","oa_version":"Submitted Version","citation":{"ista":"Charlesworth D, Barton NH, Charlesworth B. 2017. The sources of adaptive evolution. Proceedings of the Royal Society of London Series B Biological Sciences. 284(1855), 20162864.","apa":"Charlesworth, D., Barton, N. H., &#38; Charlesworth, B. (2017). The sources of adaptive evolution. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society. <a href=\"https://doi.org/10.1098/rspb.2016.2864\">https://doi.org/10.1098/rspb.2016.2864</a>","ama":"Charlesworth D, Barton NH, Charlesworth B. The sources of adaptive evolution. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2017;284(1855). doi:<a href=\"https://doi.org/10.1098/rspb.2016.2864\">10.1098/rspb.2016.2864</a>","ieee":"D. Charlesworth, N. H. Barton, and B. Charlesworth, “The sources of adaptive evolution,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 284, no. 1855. Royal Society, 2017.","mla":"Charlesworth, Deborah, et al. “The Sources of Adaptive Evolution.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 284, no. 1855, 20162864, Royal Society, 2017, doi:<a href=\"https://doi.org/10.1098/rspb.2016.2864\">10.1098/rspb.2016.2864</a>.","short":"D. Charlesworth, N.H. Barton, B. Charlesworth, Proceedings of the Royal Society of London Series B Biological Sciences 284 (2017).","chicago":"Charlesworth, Deborah, Nicholas H Barton, and Brian Charlesworth. “The Sources of Adaptive Evolution.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, 2017. <a href=\"https://doi.org/10.1098/rspb.2016.2864\">https://doi.org/10.1098/rspb.2016.2864</a>."},"intvolume":"       284","year":"2017","status":"public","quality_controlled":"1"},{"year":"2017","status":"public","quality_controlled":"1","citation":{"ista":"Nickells R, Schmitt H, Maes ME, Schlamp C. 2017. AAV2 mediated transduction of the mouse retina after optic nerve injury. Investigative Ophthalmology and Visual Science. 58(14), 6091–6104.","chicago":"Nickells, Robert, Heather Schmitt, Margaret E Maes, and Cassandra Schlamp. “AAV2 Mediated Transduction of the Mouse Retina after Optic Nerve Injury.” <i>Investigative Ophthalmology and Visual Science</i>. Association for Research in Vision &#38; Ophthalmology, 2017. <a href=\"https://doi.org/10.1167/iovs.17-22634\">https://doi.org/10.1167/iovs.17-22634</a>.","short":"R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology and Visual Science 58 (2017) 6091–6104.","ieee":"R. Nickells, H. Schmitt, M. E. Maes, and C. Schlamp, “AAV2 mediated transduction of the mouse retina after optic nerve injury,” <i>Investigative Ophthalmology and Visual Science</i>, vol. 58, no. 14. Association for Research in Vision &#38; Ophthalmology, pp. 6091–6104, 2017.","mla":"Nickells, Robert, et al. “AAV2 Mediated Transduction of the Mouse Retina after Optic Nerve Injury.” <i>Investigative Ophthalmology and Visual Science</i>, vol. 58, no. 14, Association for Research in Vision &#38; Ophthalmology, 2017, pp. 6091–104, doi:<a href=\"https://doi.org/10.1167/iovs.17-22634\">10.1167/iovs.17-22634</a>.","ama":"Nickells R, Schmitt H, Maes ME, Schlamp C. AAV2 mediated transduction of the mouse retina after optic nerve injury. <i>Investigative Ophthalmology and Visual Science</i>. 2017;58(14):6091-6104. doi:<a href=\"https://doi.org/10.1167/iovs.17-22634\">10.1167/iovs.17-22634</a>","apa":"Nickells, R., Schmitt, H., Maes, M. E., &#38; Schlamp, C. (2017). AAV2 mediated transduction of the mouse retina after optic nerve injury. <i>Investigative Ophthalmology and Visual Science</i>. Association for Research in Vision &#38; Ophthalmology. <a href=\"https://doi.org/10.1167/iovs.17-22634\">https://doi.org/10.1167/iovs.17-22634</a>"},"intvolume":"        58","date_published":"2017-12-14T00:00:00Z","doi":"10.1167/iovs.17-22634","title":"AAV2 mediated transduction of the mouse retina after optic nerve injury","external_id":{"isi":["000426781300012"]},"ddc":["576"],"date_updated":"2026-08-12T11:16:45Z","oa_version":"Published Version","date_created":"2018-12-11T11:47:10Z","publisher":"Association for Research in Vision & Ophthalmology","language":[{"iso":"eng"}],"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"has_accepted_license":"1","publist_id":"7254","month":"12","day":"14","issue":"14","department":[{"_id":"SaSi"}],"publication_status":"published","oa":1,"file_date_updated":"2020-07-14T12:47:04Z","file":[{"date_created":"2018-12-12T10:17:53Z","date_updated":"2020-07-14T12:47:04Z","file_size":2955559,"content_type":"application/pdf","access_level":"open_access","checksum":"d7a7b6f1fa9211a04e5e65634a0265d9","creator":"system","file_id":"5311","relation":"main_file","file_name":"IST-2018-920-v1+1_i1552-5783-58-14-6091.pdf"}],"publication":"Investigative Ophthalmology and Visual Science","isi":1,"article_processing_charge":"No","fulldoi":"https://doi.org/10.1167/iovs.17-22634","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","volume":58,"page":"6091 - 6104","publication_identifier":{"issn":["0146-0404"]},"abstract":[{"lang":"eng","text":"PURPOSE. Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful therapeutic for the rescue and regeneration of these cells after optic nerve damage. However, early after damage, RGCs undergo atrophic changes, including gene silencing. It is not known if these changes will deleteriously affect transduction and transgene expression, or if the therapeutic protein can influence reactivation of the endogenous genome. METHODS. Double-transgenic mice carrying a Rosa26-(LoxP)-tdTomato reporter, and a mutant allele for the proapoptotic Bax gene were reared. The Bax mutant blocks apoptosis, but RGCs still exhibit nuclear atrophy and gene silencing. At times ranging from 1 hour to 4 weeks after optic nerve crush (ONC), eyes received an intravitreal injection of AAV2 virus carrying the Cre recombinase. Successful transduction was monitored by expression of the tdTomato reporter. Immunostaining was used to localize tdTomato expression in select cell types. RESULTS. Successful transduction of RGCs was achieved at all time points after ONC using AAV2 expressing Cre from the phosphoglycerate kinase (Pgk) promoter, but not the CMV promoter. ONC promoted an increase in the transduction of cell types in the inner nuclear layer, including Müller cells and rod bipolar neurons. There was minimal evidence of transduction of amacrine cells and astrocytes in the inner retina or optic nerve. CONCLUSIONS. Damaged RGCs can be transduced and at least some endogenous genes can be subsequently activated. Optic nerve damage may change retinal architecture to allow greater penetration of an AAV2 virus to transduce several additional cell types in the inner nuclear layer."}],"type":"journal_article","pubrep_id":"920","_id":"557","author":[{"full_name":"Nickells, Robert","first_name":"Robert","last_name":"Nickells"},{"full_name":"Schmitt, Heather","last_name":"Schmitt","first_name":"Heather"},{"id":"3838F452-F248-11E8-B48F-1D18A9856A87","full_name":"Maes, Margaret E","orcid":"0000-0001-9642-1085","first_name":"Margaret E","last_name":"Maes"},{"first_name":"Cassandra","last_name":"Schlamp","full_name":"Schlamp, Cassandra"}]},{"volume":2017,"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"Bio"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1078","pubrep_id":"808","author":[{"orcid":"0000-0002-6862-1247","full_name":"Von Wangenheim, Daniel","id":"49E91952-F248-11E8-B48F-1D18A9856A87","last_name":"Von Wangenheim","first_name":"Daniel"},{"last_name":"Hauschild","first_name":"Robert","full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9843-3522"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jirí"}],"abstract":[{"lang":"eng","text":"One of the key questions in understanding plant development is how single cells behave in a larger context of the tissue. Therefore, it requires the observation of the whole organ with a high spatial- as well as temporal resolution over prolonged periods of time, which may cause photo-toxic effects. This protocol shows a plant sample preparation method for light-sheet microscopy, which is characterized by mounting the plant vertically on the surface of a gel. The plant is mounted in such a way that the roots are submerged in a liquid medium while the leaves remain in the air. In order to ensure photosynthetic activity of the plant, a custom-made lighting system illuminates the leaves. To keep the roots in darkness the water surface is covered with sheets of black plastic foil. This method allows long-term imaging of plant organ development in standardized conditions. "}],"type":"journal_article","department":[{"_id":"JiFr"},{"_id":"Bio"}],"publication_status":"published","issue":"119","day":"18","month":"01","has_accepted_license":"1","publist_id":"6302","article_processing_charge":"No","isi":1,"publication":"Journal of Visualized Experiments","fulldoi":"https://doi.org/10.3791/55044","scopus_import":"1","article_number":"e55044","file_date_updated":"2018-12-12T10:16:32Z","file":[{"date_created":"2018-12-12T10:16:31Z","file_size":57678,"date_updated":"2018-12-12T10:16:31Z","access_level":"open_access","content_type":"application/pdf","creator":"system","file_id":"5219","relation":"main_file","file_name":"IST-2017-808-v1+1_2017_VWangenheim_list.pdf"},{"date_updated":"2018-12-12T10:16:32Z","file_size":1317820,"access_level":"open_access","content_type":"application/pdf","date_created":"2018-12-12T10:16:32Z","creator":"system","file_id":"5220","relation":"main_file","file_name":"IST-2017-808-v1+2_2017_VWangenheim_article.pdf"}],"oa":1,"date_updated":"2026-08-12T14:11:08Z","ddc":["580"],"oa_version":"Published Version","date_created":"2018-12-11T11:50:01Z","project":[{"grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"grant_number":"282300","call_identifier":"FP7","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants"}],"doi":"10.3791/55044","date_published":"2017-01-18T00:00:00Z","external_id":{"isi":["000397847200041"]},"title":"Light sheet fluorescence microscopy of plant roots growing on the surface of a gel","related_material":{"record":[{"relation":"popular_science","id":"5565","status":"public"}]},"language":[{"iso":"eng"}],"publisher":"MyJove Corporation","ec_funded":1,"status":"public","year":"2017","intvolume":"      2017","citation":{"ista":"von Wangenheim D, Hauschild R, Friml J. 2017. Light sheet fluorescence microscopy of plant roots growing on the surface of a gel. Journal of Visualized Experiments. 2017(119), e55044.","ama":"von Wangenheim D, Hauschild R, Friml J. Light sheet fluorescence microscopy of plant roots growing on the surface of a gel. <i>Journal of Visualized Experiments</i>. 2017;2017(119). doi:<a href=\"https://doi.org/10.3791/55044\">10.3791/55044</a>","apa":"von Wangenheim, D., Hauschild, R., &#38; Friml, J. (2017). Light sheet fluorescence microscopy of plant roots growing on the surface of a gel. <i>Journal of Visualized Experiments</i>. MyJove Corporation. <a href=\"https://doi.org/10.3791/55044\">https://doi.org/10.3791/55044</a>","chicago":"Wangenheim, Daniel von, Robert Hauschild, and Jiří Friml. “Light Sheet Fluorescence Microscopy of Plant Roots Growing on the Surface of a Gel.” <i>Journal of Visualized Experiments</i>. MyJove Corporation, 2017. <a href=\"https://doi.org/10.3791/55044\">https://doi.org/10.3791/55044</a>.","short":"D. von Wangenheim, R. Hauschild, J. Friml, Journal of Visualized Experiments 2017 (2017).","ieee":"D. von Wangenheim, R. Hauschild, and J. Friml, “Light sheet fluorescence microscopy of plant roots growing on the surface of a gel,” <i>Journal of Visualized Experiments</i>, vol. 2017, no. 119. MyJove Corporation, 2017.","mla":"von Wangenheim, Daniel, et al. “Light Sheet Fluorescence Microscopy of Plant Roots Growing on the Surface of a Gel.” <i>Journal of Visualized Experiments</i>, vol. 2017, no. 119, e55044, MyJove Corporation, 2017, doi:<a href=\"https://doi.org/10.3791/55044\">10.3791/55044</a>."}},{"day":"10","month":"04","has_accepted_license":"1","publist_id":"6302","department":[{"_id":"JiFr"},{"_id":"Bio"}],"file":[{"relation":"main_file","file_name":"IST-2017-66-v1+1_WangenheimHighResolution55044-NEW_1.mp4","file_id":"5599","creator":"system","checksum":"b7552fc23540a85dc5a22fd4484eae71","date_created":"2018-12-12T13:02:33Z","date_updated":"2020-07-14T12:47:03Z","file_size":101497758,"content_type":"video/mp4","access_level":"open_access"}],"file_date_updated":"2020-07-14T12:47:03Z","oa":1,"fulldoi":"https://doi.org/10.15479/AT:ISTA:66","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"research_data","abstract":[{"text":"One of the key questions in understanding plant development is how single cells behave in a larger context of the tissue. Therefore, it requires the observation of the whole organ with a high spatial- as well as temporal resolution over prolonged periods of time, which may cause photo-toxic effects. This protocol shows a plant sample preparation method for light-sheet microscopy, which is characterized by mounting the plant vertically on the surface of a gel. The plant is mounted in such a way that the roots are submerged in a liquid medium while the leaves remain in the air. In order to ensure photosynthetic activity of the plant, a custom-made lighting system illuminates the leaves. To keep the roots in darkness the water surface is covered with sheets of black plastic foil. This method allows long-term imaging of plant organ development in standardized conditions. \r\nThe Video is licensed under a CC BY NC ND license. ","lang":"eng"}],"_id":"5565","acknowledgement":"fund: FP7-ERC 0101109","author":[{"first_name":"Daniel","last_name":"Von Wangenheim","id":"49E91952-F248-11E8-B48F-1D18A9856A87","full_name":"Von Wangenheim, Daniel","orcid":"0000-0002-6862-1247"},{"last_name":"Hauschild","first_name":"Robert","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert"},{"first_name":"Jirí","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596"}],"year":"2017","ec_funded":1,"status":"public","citation":{"apa":"von Wangenheim, D., Hauschild, R., &#38; Friml, J. (2017). Light Sheet Fluorescence microscopy of plant roots growing on the surface of a gel. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:66\">https://doi.org/10.15479/AT:ISTA:66</a>","ama":"von Wangenheim D, Hauschild R, Friml J. Light Sheet Fluorescence microscopy of plant roots growing on the surface of a gel. 2017. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:66\">10.15479/AT:ISTA:66</a>","ieee":"D. von Wangenheim, R. Hauschild, and J. Friml, “Light Sheet Fluorescence microscopy of plant roots growing on the surface of a gel.” Institute of Science and Technology Austria, 2017.","mla":"von Wangenheim, Daniel, et al. <i>Light Sheet Fluorescence Microscopy of Plant Roots Growing on the Surface of a Gel</i>. Institute of Science and Technology Austria, 2017, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:66\">10.15479/AT:ISTA:66</a>.","chicago":"Wangenheim, Daniel von, Robert Hauschild, and Jiří Friml. “Light Sheet Fluorescence Microscopy of Plant Roots Growing on the Surface of a Gel.” Institute of Science and Technology Austria, 2017. <a href=\"https://doi.org/10.15479/AT:ISTA:66\">https://doi.org/10.15479/AT:ISTA:66</a>.","short":"D. von Wangenheim, R. Hauschild, J. Friml, (2017).","ista":"von Wangenheim D, Hauschild R, Friml J. 2017. Light Sheet Fluorescence microscopy of plant roots growing on the surface of a gel, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:66\">10.15479/AT:ISTA:66</a>."},"datarep_id":"66","title":"Light Sheet Fluorescence microscopy of plant roots growing on the surface of a gel","doi":"10.15479/AT:ISTA:66","date_published":"2017-04-10T00:00:00Z","date_created":"2018-12-12T12:31:34Z","oa_version":"Published Version","project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734"}],"date_updated":"2026-08-12T14:11:07Z","ddc":["580"],"publisher":"Institute of Science and Technology Austria","related_material":{"record":[{"id":"1078","relation":"research_paper","status":"public"}]}},{"date_created":"2018-12-11T11:48:42Z","oa_version":"Published Version","ddc":["020"],"date_updated":"2026-08-12T14:14:50Z","title":"Metadata for research data in practice","corr_author":"1","date_published":"2017-08-01T00:00:00Z","doi":"10.31263/voebm.v70i2.1678","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"das_tickbox":"1","publisher":"Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare","language":[{"iso":"eng"}],"status":"public","year":"2017","intvolume":"        70","citation":{"chicago":"Petritsch, Barbara. “Metadata for Research Data in Practice.” <i>Mitteilungen Der Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2017. <a href=\"https://doi.org/10.31263/voebm.v70i2.1678\">https://doi.org/10.31263/voebm.v70i2.1678</a>.","short":"B. Petritsch, Mitteilungen Der Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare 70 (2017) 200–207.","mla":"Petritsch, Barbara. “Metadata for Research Data in Practice.” <i>Mitteilungen Der Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>, vol. 70, no. 2, Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2017, pp. 200–07, doi:<a href=\"https://doi.org/10.31263/voebm.v70i2.1678\">10.31263/voebm.v70i2.1678</a>.","ieee":"B. Petritsch, “Metadata for research data in practice,” <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>, vol. 70, no. 2. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, pp. 200–207, 2017.","ama":"Petritsch B. Metadata for research data in practice. <i>Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare</i>. 2017;70(2):200-207. doi:<a href=\"https://doi.org/10.31263/voebm.v70i2.1678\">10.31263/voebm.v70i2.1678</a>","apa":"Petritsch, B. (2017). Metadata for research data in practice. <i>Mitteilungen Der Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. <a href=\"https://doi.org/10.31263/voebm.v70i2.1678\">https://doi.org/10.31263/voebm.v70i2.1678</a>","ista":"Petritsch B. 2017. Metadata for research data in practice. Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. 70(2), 200–207."},"volume":70,"page":"200 - 207","publication_identifier":{"issn":["1022-2588"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"825","author":[{"id":"406048EC-F248-11E8-B48F-1D18A9856A87","full_name":"Petritsch, Barbara","orcid":"0000-0003-2724-4614","first_name":"Barbara","last_name":"Petritsch"}],"type":"journal_article","abstract":[{"text":"What data is needed about data? Describing the process to answer this question for the institutional data repository IST DataRep.","lang":"eng"}],"issue":"2","department":[{"_id":"E-Lib"}],"publication_status":"published","publist_id":"6823","has_accepted_license":"1","day":"01","month":"08","fulldoi":"https://doi.org/10.31263/voebm.v70i2.1678","scopus_import":"1","publication":"Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare","article_processing_charge":"No","oa":1,"file":[{"file_id":"5850","file_name":"2017_VOEB_Petritsch.pdf","relation":"main_file","date_created":"2019-01-18T13:32:17Z","access_level":"open_access","content_type":"application/pdf","file_size":7843975,"date_updated":"2020-07-14T12:48:11Z","creator":"dernst","checksum":"7c4544d07efa2c2add8612b489abb4e2"}],"file_date_updated":"2020-07-14T12:48:11Z"},{"date_updated":"2026-08-12T14:23:50Z","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"date_created":"2018-12-11T11:50:29Z","oa_version":"Submitted Version","date_published":"2017-01-13T00:00:00Z","doi":"10.1103/PhysRevB.95.024506","external_id":{"isi":["000391852800006"],"arxiv":["1606.03247"]},"title":"Universal properties of high temperature superconductors from real space pairing t-J-U model and its quantitative comparison with experiment","publisher":"American Physical Society","language":[{"iso":"eng"}],"quality_controlled":"1","status":"public","ec_funded":1,"year":"2017","intvolume":"        95","citation":{"ista":"Spałek J, Zegrodnik M, Kaczmarczyk J. 2017. Universal properties of high temperature superconductors from real space pairing t-J-U model and its quantitative comparison with experiment. Physical Review B. 95(2), 024506.","mla":"Spałek, Jozef, et al. “Universal Properties of High Temperature Superconductors from Real Space Pairing T-J-U Model and Its Quantitative Comparison with Experiment.” <i>Physical Review B</i>, vol. 95, no. 2, 024506, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevB.95.024506\">10.1103/PhysRevB.95.024506</a>.","ieee":"J. Spałek, M. Zegrodnik, and J. Kaczmarczyk, “Universal properties of high temperature superconductors from real space pairing t-J-U model and its quantitative comparison with experiment,” <i>Physical Review B</i>, vol. 95, no. 2. American Physical Society, 2017.","short":"J. Spałek, M. Zegrodnik, J. Kaczmarczyk, Physical Review B 95 (2017).","chicago":"Spałek, Jozef, Michał Zegrodnik, and Jan Kaczmarczyk. “Universal Properties of High Temperature Superconductors from Real Space Pairing T-J-U Model and Its Quantitative Comparison with Experiment.” <i>Physical Review B</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevB.95.024506\">https://doi.org/10.1103/PhysRevB.95.024506</a>.","apa":"Spałek, J., Zegrodnik, M., &#38; Kaczmarczyk, J. (2017). Universal properties of high temperature superconductors from real space pairing t-J-U model and its quantitative comparison with experiment. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.95.024506\">https://doi.org/10.1103/PhysRevB.95.024506</a>","ama":"Spałek J, Zegrodnik M, Kaczmarczyk J. Universal properties of high temperature superconductors from real space pairing t-J-U model and its quantitative comparison with experiment. <i>Physical Review B</i>. 2017;95(2). doi:<a href=\"https://doi.org/10.1103/PhysRevB.95.024506\">10.1103/PhysRevB.95.024506</a>"},"volume":95,"publication_identifier":{"issn":["2469-9950"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1162","author":[{"first_name":"Jozef","last_name":"Spałek","full_name":"Spałek, Jozef"},{"last_name":"Zegrodnik","first_name":"Michał","full_name":"Zegrodnik, Michał"},{"orcid":"0000-0002-1629-3675","full_name":"Kaczmarczyk, Jan","id":"46C405DE-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","last_name":"Kaczmarczyk"}],"arxiv":1,"abstract":[{"text":"Selected universal experimental properties of high-temperature superconducting (HTS) cuprates have been singled out in the last decade. One of the pivotal challenges in this field is the designation of a consistent interpretation framework within which we can describe quantitatively the universal features of those systems. Here we analyze in a detailed manner the principal experimental data and compare them quantitatively with the approach based on a single-band model of strongly correlated electrons supplemented with strong antiferromagnetic (super)exchange interaction (the so-called t−J−U model). The model rationale is provided by estimating its microscopic parameters on the basis of the three-band approach for the Cu-O plane. We use our original full Gutzwiller wave-function solution by going beyond the renormalized mean-field theory (RMFT) in a systematic manner. Our approach reproduces very well the observed hole doping (δ) dependence of the kinetic-energy gain in the superconducting phase, one of the principal non-Bardeen-Cooper-Schrieffer features of the cuprates. The calculated Fermi velocity in the nodal direction is practically δ-independent and its universal value agrees very well with that determined experimentally. Also, a weak doping dependence of the Fermi wave vector leads to an almost constant value of the effective mass in a pure superconducting phase which is both observed in experiment and reproduced within our approach. An assessment of the currently used models (t−J, Hubbard) is carried out and the results of the canonical RMFT as a zeroth-order solution are provided for comparison to illustrate the necessity of the introduced higher-order contributions.","lang":"eng"}],"type":"journal_article","issue":"2","department":[{"_id":"MiLe"}],"publication_status":"published","publist_id":"6195","month":"01","day":"13","publication":"Physical Review B","isi":1,"article_processing_charge":"No","fulldoi":"https://doi.org/10.1103/PhysRevB.95.024506","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/1606.03247","open_access":"1"}],"article_number":"024506","oa":1},{"status":"public","quality_controlled":"1","year":"2017","intvolume":"        96","citation":{"ista":"Bighin G, Lemeshko M. 2017. Diagrammatic approach to orbital quantum impurities interacting with a many-particle environment. Physical Review B. 96(8), 085410.","ama":"Bighin G, Lemeshko M. Diagrammatic approach to orbital quantum impurities interacting with a many-particle environment. <i>Physical Review B</i>. 2017;96(8). doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.085410\">10.1103/PhysRevB.96.085410</a>","apa":"Bighin, G., &#38; Lemeshko, M. (2017). Diagrammatic approach to orbital quantum impurities interacting with a many-particle environment. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.96.085410\">https://doi.org/10.1103/PhysRevB.96.085410</a>","short":"G. Bighin, M. Lemeshko, Physical Review B 96 (2017).","chicago":"Bighin, Giacomo, and Mikhail Lemeshko. “Diagrammatic Approach to Orbital Quantum Impurities Interacting with a Many-Particle Environment.” <i>Physical Review B</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevB.96.085410\">https://doi.org/10.1103/PhysRevB.96.085410</a>.","mla":"Bighin, Giacomo, and Mikhail Lemeshko. “Diagrammatic Approach to Orbital Quantum Impurities Interacting with a Many-Particle Environment.” <i>Physical Review B</i>, vol. 96, no. 8, 085410, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.085410\">10.1103/PhysRevB.96.085410</a>.","ieee":"G. Bighin and M. Lemeshko, “Diagrammatic approach to orbital quantum impurities interacting with a many-particle environment,” <i>Physical Review B</i>, vol. 96, no. 8. American Physical Society, 2017."},"date_updated":"2026-08-12T14:24:11Z","oa_version":"Submitted Version","date_created":"2018-12-11T11:49:36Z","project":[{"call_identifier":"FWF","_id":"26031614-B435-11E9-9278-68D0E5697425","name":"Quantum rotations in the presence of a many-body environment","grant_number":"P29902"}],"doi":"10.1103/PhysRevB.96.085410","date_published":"2017-08-07T00:00:00Z","corr_author":"1","title":"Diagrammatic approach to orbital quantum impurities interacting with a many-particle environment","external_id":{"isi":["000407017100009"],"arxiv":["1704.02616"]},"language":[{"iso":"eng"}],"publisher":"American Physical Society","publication_status":"published","department":[{"_id":"MiLe"}],"issue":"8","month":"08","day":"07","publist_id":"6404","article_processing_charge":"No","isi":1,"publication":"Physical Review B","fulldoi":"https://doi.org/10.1103/PhysRevB.96.085410","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/1704.02616","open_access":"1"}],"article_number":"085410","oa":1,"publication_identifier":{"issn":["2469-9950"]},"volume":96,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"_id":"995","author":[{"orcid":"0000-0001-8823-9777","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","full_name":"Bighin, Giacomo","last_name":"Bighin","first_name":"Giacomo"},{"first_name":"Mikhail","last_name":"Lemeshko","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802"}],"abstract":[{"text":"Recently it was shown that an impurity exchanging orbital angular momentum with a surrounding bath can be described in terms of the angulon quasiparticle [Phys. Rev. Lett. 118, 095301 (2017)]. The angulon consists of a quantum rotor dressed by a many-particle field of boson excitations, and can be formed out of, for example, a molecule or a nonspherical atom in superfluid helium, or out of an electron coupled to lattice phonons or a Bose condensate. Here we develop an approach to the angulon based on the path-integral formalism, which sets the ground for a systematic, perturbative treatment of the angulon problem. The resulting perturbation series can be interpreted in terms of Feynman diagrams, from which, in turn, one can derive a set of diagrammatic rules. These rules extend the machinery of the graphical theory of angular momentum - well known from theoretical atomic spectroscopy - to the case where an environment with an infinite number of degrees of freedom is present. In particular, we show that each diagram can be interpreted as a 'skeleton', which enforces angular momentum conservation, dressed by an additional many-body contribution. This connection between the angulon theory and the graphical theory of angular momentum is particularly important as it allows to systematically and substantially simplify the analytical representation of each diagram. In order to exemplify the technique, we calculate the 1- and 2-loop contributions to the angulon self-energy, the spectral function, and the quasiparticle weight. The diagrammatic theory we develop paves the way to investigate next-to-leading order quantities in a more compact way compared to the variational approaches.","lang":"eng"}],"type":"journal_article"},{"language":[{"iso":"eng"}],"publisher":"American Physical Society","date_updated":"2026-08-12T14:24:27Z","oa_version":"Submitted Version","date_created":"2018-12-11T11:48:45Z","doi":"10.1103/PhysRevB.96.104201","date_published":"2017-09-06T00:00:00Z","external_id":{"arxiv":["1610.02389"],"isi":["000409429300004"]},"title":"Thouless energy and multifractality across the many-body localization transition","intvolume":"        96","citation":{"ista":"Serbyn M, Zlatko P, Abanin D. 2017. Thouless energy and multifractality across the many-body localization transition. Physical Review B. 96(10), 104201.","chicago":"Serbyn, Maksym, Papic Zlatko, and Dmitry Abanin. “Thouless Energy and Multifractality across the Many-Body Localization Transition.” <i>Physical Review B</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevB.96.104201\">https://doi.org/10.1103/PhysRevB.96.104201</a>.","short":"M. Serbyn, P. Zlatko, D. Abanin, Physical Review B 96 (2017).","mla":"Serbyn, Maksym, et al. “Thouless Energy and Multifractality across the Many-Body Localization Transition.” <i>Physical Review B</i>, vol. 96, no. 10, 104201, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.104201\">10.1103/PhysRevB.96.104201</a>.","ieee":"M. Serbyn, P. Zlatko, and D. Abanin, “Thouless energy and multifractality across the many-body localization transition,” <i>Physical Review B</i>, vol. 96, no. 10. American Physical Society, 2017.","ama":"Serbyn M, Zlatko P, Abanin D. Thouless energy and multifractality across the many-body localization transition. <i>Physical Review B</i>. 2017;96(10). doi:<a href=\"https://doi.org/10.1103/PhysRevB.96.104201\">10.1103/PhysRevB.96.104201</a>","apa":"Serbyn, M., Zlatko, P., &#38; Abanin, D. (2017). Thouless energy and multifractality across the many-body localization transition. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.96.104201\">https://doi.org/10.1103/PhysRevB.96.104201</a>"},"status":"public","quality_controlled":"1","year":"2017","arxiv":1,"_id":"834","author":[{"last_name":"Serbyn","first_name":"Maksym","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","full_name":"Serbyn, Maksym"},{"first_name":"Papic","last_name":"Zlatko","full_name":"Zlatko, Papic"},{"full_name":"Abanin, Dmitry","last_name":"Abanin","first_name":"Dmitry"}],"acknowledgement":"We   acknowledge   useful   discussions with V. Kravtsov, T. Grover, and R. Vasseur.  M.S. was supported by Gordon and Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4307.  M.S. and D.A.  acknowledge  hospitality  of  KITP,  where  parts  of this work were completed (supported in part by the National Science Foundation under Grant No. NSF PHY11-25915)","abstract":[{"text":"Thermal and many-body localized phases are separated by a dynamical phase transition of a new kind. We analyze the distribution of off-diagonal matrix elements of local operators across this transition in two different models of disordered spin chains. We show that the behavior of matrix elements can be used to characterize the breakdown of thermalization and to extract the many-body Thouless energy. We find that upon increasing the disorder strength the system enters a critical region around the many-body localization transition. The properties of the system in this region are: (i) the Thouless energy becomes smaller than the level spacing, (ii) the matrix elements show critical dependence on the energy difference, and (iii) the matrix elements, viewed as amplitudes of a fictitious wave function, exhibit strong multifractality. This critical region decreases with the system size, which we interpret as evidence for a diverging correlation length at the many-body localization transition. Our findings show that the correlation length becomes larger than the accessible system sizes in a broad range of disorder strength values and shed light on the critical behavior near the many-body localization transition.","lang":"eng"}],"type":"journal_article","publication_identifier":{"issn":["2469-9950"]},"volume":96,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","isi":1,"publication":"Physical Review B","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1610.02389"}],"fulldoi":"https://doi.org/10.1103/PhysRevB.96.104201","scopus_import":"1","article_number":"104201","oa":1,"department":[{"_id":"MaSe"}],"publication_status":"published","issue":"10","month":"09","day":"06","publist_id":"6814"},{"intvolume":"        96","citation":{"apa":"De Martino, D., Capuani, F., &#38; De Martino, A. (2017). Quantifying the entropic cost of cellular growth control. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.96.010401\">https://doi.org/10.1103/PhysRevE.96.010401</a>","ama":"De Martino D, Capuani F, De Martino A. Quantifying the entropic cost of cellular growth control. <i>Physical Review E</i>. 2017;96(1). doi:<a href=\"https://doi.org/10.1103/PhysRevE.96.010401\">10.1103/PhysRevE.96.010401</a>","ieee":"D. De Martino, F. Capuani, and A. De Martino, “Quantifying the entropic cost of cellular growth control,” <i>Physical Review E</i>, vol. 96, no. 1. American Physical Society, 2017.","mla":"De Martino, Daniele, et al. “Quantifying the Entropic Cost of Cellular Growth Control.” <i>Physical Review E</i>, vol. 96, no. 1, 010401, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevE.96.010401\">10.1103/PhysRevE.96.010401</a>.","chicago":"De Martino, Daniele, Fabrizio Capuani, and Andrea De Martino. “Quantifying the Entropic Cost of Cellular Growth Control.” <i>Physical Review E</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevE.96.010401\">https://doi.org/10.1103/PhysRevE.96.010401</a>.","short":"D. De Martino, F. Capuani, A. De Martino, Physical Review E 96 (2017).","ista":"De Martino D, Capuani F, De Martino A. 2017. Quantifying the entropic cost of cellular growth control. Physical Review E. 96(1), 010401."},"ec_funded":1,"status":"public","quality_controlled":"1","year":"2017","publisher":"American Physical Society","language":[{"iso":"eng"}],"das_tickbox":"1","date_updated":"2026-08-12T14:29:46Z","oa_version":"Submitted Version","date_created":"2018-12-11T11:49:21Z","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"}],"doi":"10.1103/PhysRevE.96.010401","date_published":"2017-07-10T00:00:00Z","external_id":{"isi":["000405194200002"],"arxiv":["1703.00219"]},"title":"Quantifying the entropic cost of cellular growth control","article_processing_charge":"No","isi":1,"publication":"Physical Review E","main_file_link":[{"url":"https://arxiv.org/abs/1703.00219","open_access":"1"}],"fulldoi":"https://doi.org/10.1103/PhysRevE.96.010401","scopus_import":"1","article_number":"010401","oa":1,"department":[{"_id":"GaTk"}],"publication_status":"published","issue":"1","day":"10","month":"07","publist_id":"6470","arxiv":1,"author":[{"last_name":"De Martino","first_name":"Daniele","orcid":"0000-0002-5214-4706","full_name":"De Martino, Daniele","id":"3FF5848A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Fabrizio","last_name":"Capuani","full_name":"Capuani, Fabrizio"},{"full_name":"De Martino, Andrea","first_name":"Andrea","last_name":"De Martino"}],"_id":"947","abstract":[{"text":"Viewing the ways a living cell can organize its metabolism as the phase space of a physical system, regulation can be seen as the ability to reduce the entropy of that space by selecting specific cellular configurations that are, in some sense, optimal. Here we quantify the amount of regulation required to control a cell's growth rate by a maximum-entropy approach to the space of underlying metabolic phenotypes, where a configuration corresponds to a metabolic flux pattern as described by genome-scale models. We link the mean growth rate achieved by a population of cells to the minimal amount of metabolic regulation needed to achieve it through a phase diagram that highlights how growth suppression can be as costly (in regulatory terms) as growth enhancement. Moreover, we provide an interpretation of the inverse temperature β controlling maximum-entropy distributions based on the underlying growth dynamics. Specifically, we show that the asymptotic value of β for a cell population can be expected to depend on (i) the carrying capacity of the environment, (ii) the initial size of the colony, and (iii) the probability distribution from which the inoculum was sampled. Results obtained for E. coli and human cells are found to be remarkably consistent with empirical evidence.","lang":"eng"}],"type":"journal_article","publication_identifier":{"issn":["2470-0045"]},"volume":96,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_updated":"2026-08-12T14:29:59Z","oa_version":"Submitted Version","date_created":"2018-12-11T11:48:00Z","project":[{"name":"Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination with cavity Optomechanics","_id":"258047B6-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"707438"}],"doi":"10.1103/PhysRevE.96.012404","date_published":"2017-07-12T00:00:00Z","title":"Optomechanical proposal for monitoring microtubule mechanical vibrations","external_id":{"arxiv":["1612.07061"],"isi":["000405367200012"]},"language":[{"iso":"eng"}],"publisher":"American Physical Society","das_tickbox":"1","ec_funded":1,"status":"public","quality_controlled":"1","year":"2017","intvolume":"        96","citation":{"mla":"Barzanjeh, Shabir, et al. “Optomechanical Proposal for Monitoring Microtubule Mechanical Vibrations.” <i>Physical Review E</i>, vol. 96, no. 1, 012404, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1103/PhysRevE.96.012404\">10.1103/PhysRevE.96.012404</a>.","ieee":"S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, and C. Simon, “Optomechanical proposal for monitoring microtubule mechanical vibrations,” <i>Physical Review E</i>, vol. 96, no. 1. American Physical Society, 2017.","chicago":"Barzanjeh, Shabir, Vahid Salari, Jack Tuszynski, Michal Cifra, and Christoph Simon. “Optomechanical Proposal for Monitoring Microtubule Mechanical Vibrations.” <i>Physical Review E</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevE.96.012404\">https://doi.org/10.1103/PhysRevE.96.012404</a>.","short":"S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, C. Simon, Physical Review E 96 (2017).","apa":"Barzanjeh, S., Salari, V., Tuszynski, J., Cifra, M., &#38; Simon, C. (2017). Optomechanical proposal for monitoring microtubule mechanical vibrations. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.96.012404\">https://doi.org/10.1103/PhysRevE.96.012404</a>","ama":"Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. Optomechanical proposal for monitoring microtubule mechanical vibrations. <i>Physical Review E</i>. 2017;96(1). doi:<a href=\"https://doi.org/10.1103/PhysRevE.96.012404\">10.1103/PhysRevE.96.012404</a>","ista":"Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. 2017. Optomechanical proposal for monitoring microtubule mechanical vibrations. Physical Review E. 96(1), 012404."},"publication_identifier":{"issn":["2470-0045"]},"volume":96,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","arxiv":1,"author":[{"first_name":"Shabir","last_name":"Barzanjeh","orcid":"0000-0003-0415-1423","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","full_name":"Barzanjeh, Shabir"},{"first_name":"Vahid","last_name":"Salari","full_name":"Salari, Vahid"},{"last_name":"Tuszynski","first_name":"Jack","full_name":"Tuszynski, Jack"},{"full_name":"Cifra, Michal","last_name":"Cifra","first_name":"Michal"},{"first_name":"Christoph","last_name":"Simon","full_name":"Simon, Christoph"}],"_id":"700","abstract":[{"text":"Microtubules provide the mechanical force required for chromosome separation during mitosis. However, little is known about the dynamic (high-frequency) mechanical properties of microtubules. Here, we theoretically propose to control the vibrations of a doubly clamped microtubule by tip electrodes and to detect its motion via the optomechanical coupling between the vibrational modes of the microtubule and an optical cavity. In the presence of a red-detuned strong pump laser, this coupling leads to optomechanical-induced transparency of an optical probe field, which can be detected with state-of-the art technology. The center frequency and line width of the transparency peak give the resonance frequency and damping rate of the microtubule, respectively, while the height of the peak reveals information about the microtubule-cavity field coupling. Our method opens the new possibilities to gain information about the physical properties of microtubules, which will enhance our capability to design physical cancer treatment protocols as alternatives to chemotherapeutic drugs.","lang":"eng"}],"type":"journal_article","publication_status":"published","department":[{"_id":"JoFi"}],"issue":"1","month":"07","day":"12","publist_id":"6997","article_processing_charge":"No","isi":1,"publication":"Physical Review E","scopus_import":"1","fulldoi":"https://doi.org/10.1103/PhysRevE.96.012404","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1612.07061"}],"article_number":"012404","oa":1},{"date_published":"2017-06-28T00:00:00Z","doi":"10.1103/PhysRevE.95.062419","external_id":{"isi":["000404546400004"],"arxiv":["1703.00853"]},"title":"Scales and multimodal flux distributions in stationary metabolic network models via thermodynamics","date_updated":"2026-08-12T14:29:35Z","project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"oa_version":"Submitted Version","date_created":"2018-12-11T11:49:25Z","das_tickbox":"1","language":[{"iso":"eng"}],"publisher":"American Physical Society","year":"2017","status":"public","quality_controlled":"1","ec_funded":1,"citation":{"short":"D. De Martino, Physical Review E 95 (2017) 062419.","chicago":"De Martino, Daniele. “Scales and Multimodal Flux Distributions in Stationary Metabolic Network Models via Thermodynamics.” <i>Physical Review E</i>. American Physical Society, 2017. <a href=\"https://doi.org/10.1103/PhysRevE.95.062419\">https://doi.org/10.1103/PhysRevE.95.062419</a>.","mla":"De Martino, Daniele. “Scales and Multimodal Flux Distributions in Stationary Metabolic Network Models via Thermodynamics.” <i>Physical Review E</i>, vol. 95, no. 6, American Physical Society, 2017, p. 062419, doi:<a href=\"https://doi.org/10.1103/PhysRevE.95.062419\">10.1103/PhysRevE.95.062419</a>.","ieee":"D. De Martino, “Scales and multimodal flux distributions in stationary metabolic network models via thermodynamics,” <i>Physical Review E</i>, vol. 95, no. 6. American Physical Society, p. 062419, 2017.","ama":"De Martino D. Scales and multimodal flux distributions in stationary metabolic network models via thermodynamics. <i>Physical Review E</i>. 2017;95(6):062419. doi:<a href=\"https://doi.org/10.1103/PhysRevE.95.062419\">10.1103/PhysRevE.95.062419</a>","apa":"De Martino, D. (2017). Scales and multimodal flux distributions in stationary metabolic network models via thermodynamics. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.95.062419\">https://doi.org/10.1103/PhysRevE.95.062419</a>","ista":"De Martino D. 2017. Scales and multimodal flux distributions in stationary metabolic network models via thermodynamics. Physical Review E. 95(6), 062419."},"intvolume":"        95","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":95,"page":"062419","publication_identifier":{"issn":["2470-0045"]},"abstract":[{"lang":"eng","text":"In this work it is shown that scale-free tails in metabolic flux distributions inferred in stationary models are an artifact due to reactions involved in thermodynamically unfeasible cycles, unbounded by physical constraints and in principle able to perform work without expenditure of free energy. After implementing thermodynamic constraints by removing such loops, metabolic flux distributions scale meaningfully with the physical limiting factors, acquiring in turn a richer multimodal structure potentially leading to symmetry breaking while optimizing for objective functions."}],"type":"journal_article","author":[{"first_name":"Daniele","last_name":"De Martino","full_name":"De Martino, Daniele","id":"3FF5848A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5214-4706"}],"_id":"959","arxiv":1,"publist_id":"6446","day":"28","month":"06","issue":"6","publication_status":"published","department":[{"_id":"GaTk"}],"oa":1,"isi":1,"publication":"Physical Review E","article_processing_charge":"No","fulldoi":"https://doi.org/10.1103/PhysRevE.95.062419","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1703.00853"}],"scopus_import":"1"},{"author":[{"orcid":"0000-0002-5837-2793","id":"409D5C96-F248-11E8-B48F-1D18A9856A87","full_name":"Fernandes Redondo, Rodrigo A","last_name":"Fernandes Redondo","first_name":"Rodrigo A"},{"id":"2A181218-F248-11E8-B48F-1D18A9856A87","full_name":"Vladar, Harold","orcid":"0000-0002-5985-7653","first_name":"Harold","last_name":"Vladar"},{"last_name":"Włodarski","first_name":"Tomasz","full_name":"Włodarski, Tomasz"},{"last_name":"Bollback","first_name":"Jonathan P","orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","full_name":"Bollback, Jonathan P"}],"_id":"1077","type":"journal_article","abstract":[{"lang":"eng","text":"Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the rates of substitution. To study the evolution of epistasis, we focused on the major structural protein of the fX174 phage family by first reconstructing the ancestral protein sequences of 18 species using a Bayesian statistical framework. The inferred ancestral reconstruction differed at eight AAs, for a total of 256 possible ancestral haplotypes. For each ancestral haplotype and the extant species, we estimated, in silico, the distribution of free energies and epistasis of the capsid structure. We found that free energy has not significantly increased but epistasis has. We decomposed epistasis up to fifth order and found that higher-order epistasis sometimes compensates pairwise interactions making the free energy seem additive. The dN/dS ratio is low, suggesting strong purifying selection, and that structure is under stabilizing selection. We synthesized phages carrying ancestral haplotypes of the coat protein gene and measured their fitness experimentally. Our findings indicate that stabilizing mutations can have higher fitness, and that fitness optima do not necessarily coincide with energy minima."}],"volume":14,"publication_identifier":{"issn":["1742-5689"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","fulldoi":"https://doi.org/10.1098/rsif.2016.0139","scopus_import":"1","publication":"Journal of the Royal Society Interface","isi":1,"article_processing_charge":"Yes (in subscription journal)","oa":1,"file":[{"creator":"dernst","date_created":"2019-01-18T09:14:02Z","access_level":"open_access","content_type":"application/pdf","file_size":1092015,"date_updated":"2019-01-18T09:14:02Z","file_name":"2017_JRSI_Redondo.pdf","relation":"main_file","file_id":"5843","success":1}],"file_date_updated":"2019-01-18T09:14:02Z","article_number":"20160139","issue":"126","department":[{"_id":"NiBa"},{"_id":"JoBo"}],"publication_status":"published","publist_id":"6303","has_accepted_license":"1","month":"01","day":"04","related_material":{"record":[{"relation":"research_data","id":"9864","status":"public"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"publisher":"Royal Society","project":[{"name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152"},{"grant_number":"648440","name":"Selective Barriers to Horizontal Gene Transfer","_id":"2578D616-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"oa_version":"Published Version","date_created":"2018-12-11T11:50:01Z","ddc":["570"],"date_updated":"2026-08-27T12:09:33Z","external_id":{"isi":["000393380400001"]},"title":"Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family","date_published":"2017-01-04T00:00:00Z","doi":"10.1098/rsif.2016.0139","intvolume":"        14","citation":{"ista":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. 2017. Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. Journal of the Royal Society Interface. 14(126), 20160139.","apa":"Fernandes Redondo, R. A., de Vladar, H., Włodarski, T., &#38; Bollback, J. P. (2017). Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2016.0139\">https://doi.org/10.1098/rsif.2016.0139</a>","ama":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. <i>Journal of the Royal Society Interface</i>. 2017;14(126). doi:<a href=\"https://doi.org/10.1098/rsif.2016.0139\">10.1098/rsif.2016.0139</a>","mla":"Fernandes Redondo, Rodrigo A., et al. “Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family.” <i>Journal of the Royal Society Interface</i>, vol. 14, no. 126, 20160139, Royal Society, 2017, doi:<a href=\"https://doi.org/10.1098/rsif.2016.0139\">10.1098/rsif.2016.0139</a>.","ieee":"R. A. Fernandes Redondo, H. de Vladar, T. Włodarski, and J. P. Bollback, “Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family,” <i>Journal of the Royal Society Interface</i>, vol. 14, no. 126. Royal Society, 2017.","short":"R.A. Fernandes Redondo, H. de Vladar, T. Włodarski, J.P. Bollback, Journal of the Royal Society Interface 14 (2017).","chicago":"Fernandes Redondo, Rodrigo A, Harold de Vladar, Tomasz Włodarski, and Jonathan P Bollback. “Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2017. <a href=\"https://doi.org/10.1098/rsif.2016.0139\">https://doi.org/10.1098/rsif.2016.0139</a>."},"quality_controlled":"1","status":"public","ec_funded":1,"year":"2017"},{"main_file_link":[{"open_access":"1","url":"https://asc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc17/BOOKLET_AHPC17.pdf"}],"publication":"AHPC17 – Austrian HPC Meeting 2017","article_processing_charge":"No","citation":{"ista":"Schlögl A, Kiss J. 2017. Scientific Computing at IST Austria. AHPC17 – Austrian HPC Meeting 2017. AHPC: Austrian HPC Meeting, 28.","short":"A. Schlögl, J. Kiss, in:, AHPC17 – Austrian HPC Meeting 2017, FSP Scientific Computing, 2017, p. 28.","chicago":"Schlögl, Alois, and Janos Kiss. “Scientific Computing at IST Austria.” In <i>AHPC17 – Austrian HPC Meeting 2017</i>, 28. FSP Scientific Computing, 2017.","mla":"Schlögl, Alois, and Janos Kiss. “Scientific Computing at IST Austria.” <i>AHPC17 – Austrian HPC Meeting 2017</i>, FSP Scientific Computing, 2017, p. 28.","ieee":"A. Schlögl and J. Kiss, “Scientific Computing at IST Austria,” in <i>AHPC17 – Austrian HPC Meeting 2017</i>, Grundlsee, Austria, 2017, p. 28.","ama":"Schlögl A, Kiss J. Scientific Computing at IST Austria. In: <i>AHPC17 – Austrian HPC Meeting 2017</i>. FSP Scientific Computing; 2017:28.","apa":"Schlögl, A., &#38; Kiss, J. (2017). Scientific Computing at IST Austria. In <i>AHPC17 – Austrian HPC Meeting 2017</i> (p. 28). Grundlsee, Austria: FSP Scientific Computing."},"oa":1,"file_date_updated":"2023-05-16T07:20:50Z","file":[{"success":1,"file_id":"12969","relation":"main_file","file_name":"2017_AHPC_Schloegl.pdf","date_updated":"2023-05-16T07:20:50Z","file_size":1005486,"access_level":"open_access","content_type":"application/pdf","date_created":"2023-05-16T07:20:50Z","creator":"dernst","checksum":"7bcc499479d4f4c5ce6c0071c24ca6c6"}],"publication_status":"published","department":[{"_id":"ScienComp"}],"status":"public","year":"2017","has_accepted_license":"1","month":"03","day":"03","author":[{"first_name":"Alois","last_name":"Schlögl","orcid":"0000-0002-5621-8100","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","full_name":"Schlögl, Alois"},{"first_name":"Janos","last_name":"Kiss","id":"3D3A06F8-F248-11E8-B48F-1D18A9856A87","full_name":"Kiss, Janos"}],"_id":"12905","conference":{"name":"AHPC: Austrian HPC Meeting","end_date":"2017-03-03","start_date":"2017-03-01","location":"Grundlsee, Austria"},"type":"conference_abstract","language":[{"iso":"eng"}],"publisher":"FSP Scientific Computing","date_created":"2023-05-05T12:58:53Z","oa_version":"Published Version","ddc":["000"],"date_updated":"2026-10-14T09:39:37Z","page":"28","title":"Scientific Computing at IST Austria","corr_author":"1","date_published":"2017-03-03T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publisher":"American Society for Clinical Investigation","language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"dissertation_contains","id":"12401","status":"public"}]},"external_id":{"pmid":["28504646"],"isi":["000402620800008"]},"title":"The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection","doi":"10.1172/JCI80631","date_published":"2017-06-01T00:00:00Z","oa_version":"Submitted Version","date_created":"2018-12-11T11:47:53Z","project":[{"name":"The biochemical basis of PAR polarization","call_identifier":"FWF","_id":"25985A36-B435-11E9-9278-68D0E5697425","grant_number":"T00817-B21"},{"grant_number":"P27201-B22","_id":"25E9AF9E-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Revealing the mechanisms underlying drug interactions"}],"date_updated":"2026-11-04T23:30:14Z","pmid":1,"citation":{"ista":"Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt MK, Kovarik P. 2017. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of Clinical Investigation. 127(6), 2051–2065.","ieee":"F. Ebner <i>et al.</i>, “The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection,” <i>The Journal of Clinical Investigation</i>, vol. 127, no. 6. American Society for Clinical Investigation, pp. 2051–2065, 2017.","mla":"Ebner, Florian, et al. “The RNA-Binding Protein Tristetraprolin Schedules Apoptosis of Pathogen-Engaged Neutrophils during Bacterial Infection.” <i>The Journal of Clinical Investigation</i>, vol. 127, no. 6, American Society for Clinical Investigation, 2017, pp. 2051–65, doi:<a href=\"https://doi.org/10.1172/JCI80631\">10.1172/JCI80631</a>.","short":"F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.","chicago":"Ebner, Florian, Vitaly Sedlyarov, Saren Tasciyan, Masa Ivin, Franz Kratochvill, Nina Gratz, Lukas Kenner, Andreas Villunger, Michael K Sixt, and Pavel Kovarik. “The RNA-Binding Protein Tristetraprolin Schedules Apoptosis of Pathogen-Engaged Neutrophils during Bacterial Infection.” <i>The Journal of Clinical Investigation</i>. American Society for Clinical Investigation, 2017. <a href=\"https://doi.org/10.1172/JCI80631\">https://doi.org/10.1172/JCI80631</a>.","apa":"Ebner, F., Sedlyarov, V., Tasciyan, S., Ivin, M., Kratochvill, F., Gratz, N., … Kovarik, P. (2017). The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. <i>The Journal of Clinical Investigation</i>. American Society for Clinical Investigation. <a href=\"https://doi.org/10.1172/JCI80631\">https://doi.org/10.1172/JCI80631</a>","ama":"Ebner F, Sedlyarov V, Tasciyan S, et al. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. <i>The Journal of Clinical Investigation</i>. 2017;127(6):2051-2065. doi:<a href=\"https://doi.org/10.1172/JCI80631\">10.1172/JCI80631</a>"},"intvolume":"       127","year":"2017","quality_controlled":"1","status":"public","type":"journal_article","abstract":[{"lang":"eng","text":"Protective responses against pathogens require a rapid mobilization of resting neutrophils and the timely removal of activated ones. Neutrophils are exceptionally short-lived leukocytes, yet it remains unclear whether the lifespan of pathogen-engaged neutrophils is regulated differently from that in the circulating steady-state pool. Here, we have found that under homeostatic conditions, the mRNA-destabilizing protein tristetraprolin (TTP) regulates apoptosis and the numbers of activated infiltrating murine neutrophils but not neutrophil cellularity. Activated TTP-deficient neutrophils exhibited decreased apoptosis and enhanced accumulation at the infection site. In the context of myeloid-specific deletion of Ttp, the potentiation of neutrophil deployment protected mice against lethal soft tissue infection with Streptococcus pyogenes and prevented bacterial dissemination. Neutrophil transcriptome analysis revealed that decreased apoptosis of TTP-deficient neutrophils was specifically associated with elevated expression of myeloid cell leukemia 1 (Mcl1) but not other antiapoptotic B cell leukemia/ lymphoma 2 (Bcl2) family members. Higher Mcl1 expression resulted from stabilization of Mcl1 mRNA in the absence of TTP. The low apoptosis rate of infiltrating TTP-deficient neutrophils was comparable to that of transgenic Mcl1-overexpressing neutrophils. Our study demonstrates that posttranscriptional gene regulation by TTP schedules the termination of the antimicrobial engagement of neutrophils. The balancing role of TTP comes at the cost of an increased risk of bacterial infections."}],"_id":"679","acknowledgement":"This work was supported by grants from the Austrian Science Fund (FWF) (P27538-B21, I1621-B22, and SFB 43, to PK); by funding from the European Union Seventh Framework Programme Marie Curie Initial Training Networks (FP7-PEOPLE-2012-ITN) for the project INBIONET (INfection BIOlogy Training NETwork under grant agreement PITN-GA-2012-316682; and by a joint research cluster initiative of the University of Vienna and the Medical University of Vienna.","author":[{"full_name":"Ebner, Florian","last_name":"Ebner","first_name":"Florian"},{"full_name":"Sedlyarov, Vitaly","last_name":"Sedlyarov","first_name":"Vitaly"},{"first_name":"Saren","last_name":"Tasciyan","orcid":"0000-0003-1671-393X","full_name":"Tasciyan, Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Ivin","first_name":"Masa","full_name":"Ivin, Masa"},{"last_name":"Kratochvill","first_name":"Franz","full_name":"Kratochvill, Franz"},{"first_name":"Nina","last_name":"Gratz","full_name":"Gratz, Nina"},{"full_name":"Kenner, Lukas","first_name":"Lukas","last_name":"Kenner"},{"last_name":"Villunger","first_name":"Andreas","full_name":"Villunger, Andreas"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt"},{"last_name":"Kovarik","first_name":"Pavel","full_name":"Kovarik, Pavel"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"2051 - 2065","publication_identifier":{"issn":["0021-9738"]},"volume":127,"oa":1,"fulldoi":"https://doi.org/10.1172/JCI80631","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451238/","open_access":"1"}],"article_processing_charge":"No","isi":1,"publication":"The Journal of Clinical Investigation","month":"06","day":"01","publist_id":"7038","publication_status":"published","department":[{"_id":"MiSi"}],"issue":"6"},{"_id":"704","pubrep_id":"890","author":[{"orcid":"0000-0003-1229-9719","full_name":"Steinrück, Magdalena","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","last_name":"Steinrück","first_name":"Magdalena"},{"first_name":"Calin C","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","full_name":"Guet, Calin C","orcid":"0000-0001-6220-2052"}],"type":"journal_article","abstract":[{"text":"How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resistance gene inserted at different positions of the Escherichia coli chromosome. Using a dual-fluorescence reporter that allows us to distinguish gene amplifications from other up-mutations, we track in real-time adaptive changes in expression of the drug-resistance gene. We find that the relative contribution of several mutation types differs systematically between loci due to properties of neighboring genes: essentiality, expression, orientation, termination, and presence of duplicates. These properties determine rate and fitness effects of gene amplification, deletions, and mutations compromising transcriptional termination. Thus, the adaptive potential of a gene under selection is a system-property with a complex genetic basis that is specific for each chromosomal locus, and it can be inferred from detailed functional and genomic data.","lang":"eng"}],"volume":6,"publication_identifier":{"issn":["2050-084X"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","fulldoi":"https://doi.org/10.7554/eLife.25100","isi":1,"publication":"eLife","article_processing_charge":"No","oa":1,"file_date_updated":"2020-07-14T12:47:48Z","file":[{"creator":"system","checksum":"6b908b5db9f61f6820ebd7f8fa815571","content_type":"application/pdf","access_level":"open_access","date_updated":"2020-07-14T12:47:48Z","file_size":2092088,"date_created":"2018-12-12T10:12:54Z","file_name":"IST-2017-890-v1+1_elife-25100-v1.pdf","relation":"main_file","file_id":"4975"},{"checksum":"ca21530389b720243552678125fdba35","creator":"system","content_type":"application/pdf","access_level":"open_access","file_size":3428681,"date_updated":"2020-07-14T12:47:48Z","date_created":"2018-12-12T10:12:55Z","file_name":"IST-2017-890-v1+2_elife-25100-figures-v1.pdf","relation":"main_file","file_id":"4976"}],"article_number":"e25100","publication_status":"published","department":[{"_id":"CaGu"}],"publist_id":"6990","has_accepted_license":"1","month":"07","day":"25","related_material":{"record":[{"id":"5564","relation":"popular_science","status":"public"},{"id":"26","relation":"dissertation_contains","status":"public"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"language":[{"iso":"eng"}],"publisher":"eLife Sciences Publications","date_created":"2018-12-11T11:48:01Z","oa_version":"Published Version","ddc":["576"],"date_updated":"2026-11-04T23:30:18Z","external_id":{"isi":["000406183700001"]},"title":"Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection","corr_author":"1","date_published":"2017-07-25T00:00:00Z","doi":"10.7554/eLife.25100","intvolume":"         6","citation":{"apa":"Steinrück, M., &#38; Guet, C. C. (2017). Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.25100\">https://doi.org/10.7554/eLife.25100</a>","ama":"Steinrück M, Guet CC. Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. <i>eLife</i>. 2017;6. doi:<a href=\"https://doi.org/10.7554/eLife.25100\">10.7554/eLife.25100</a>","mla":"Steinrück, Magdalena, and Calin C. Guet. “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.” <i>ELife</i>, vol. 6, e25100, eLife Sciences Publications, 2017, doi:<a href=\"https://doi.org/10.7554/eLife.25100\">10.7554/eLife.25100</a>.","ieee":"M. Steinrück and C. C. Guet, “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection,” <i>eLife</i>, vol. 6. eLife Sciences Publications, 2017.","short":"M. Steinrück, C.C. Guet, ELife 6 (2017).","chicago":"Steinrück, Magdalena, and Calin C Guet. “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.” <i>ELife</i>. eLife Sciences Publications, 2017. <a href=\"https://doi.org/10.7554/eLife.25100\">https://doi.org/10.7554/eLife.25100</a>.","ista":"Steinrück M, Guet CC. 2017. Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. eLife. 6, e25100."},"quality_controlled":"1","status":"public","year":"2017"},{"doi":"10.1016/j.devcel.2017.09.014","date_published":"2017-10-23T00:00:00Z","corr_author":"1","title":"An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate","external_id":{"isi":["000413443700011"]},"date_updated":"2026-11-04T23:30:21Z","oa_version":"None","date_created":"2018-12-11T11:48:13Z","project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"_id":"252DD2A6-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Cell segregation in gastrulation: the role of cell fate specification","grant_number":"I2058"}],"publisher":"Cell Press","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"961","relation":"dissertation_contains","status":"public"},{"id":"8350","relation":"dissertation_contains","status":"public"}]},"year":"2017","ec_funded":1,"status":"public","quality_controlled":"1","citation":{"short":"V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.","chicago":"Barone, Vanessa, Moritz Lang, Gabriel Krens, Saurabh Pradhan, Shayan Shamipour, Keisuke Sako, Mateusz K Sikora, Calin C Guet, and Carl-Philipp J Heisenberg. “An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.” <i>Developmental Cell</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">https://doi.org/10.1016/j.devcel.2017.09.014</a>.","ieee":"V. Barone <i>et al.</i>, “An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate,” <i>Developmental Cell</i>, vol. 43, no. 2. Cell Press, pp. 198–211, 2017.","mla":"Barone, Vanessa, et al. “An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.” <i>Developmental Cell</i>, vol. 43, no. 2, Cell Press, 2017, pp. 198–211, doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">10.1016/j.devcel.2017.09.014</a>.","ama":"Barone V, Lang M, Krens G, et al. An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. <i>Developmental Cell</i>. 2017;43(2):198-211. doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">10.1016/j.devcel.2017.09.014</a>","apa":"Barone, V., Lang, M., Krens, G., Pradhan, S., Shamipour, S., Sako, K., … Heisenberg, C.-P. J. (2017). An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">https://doi.org/10.1016/j.devcel.2017.09.014</a>","ista":"Barone V, Lang M, Krens G, Pradhan S, Shamipour S, Sako K, Sikora MK, Guet CC, Heisenberg C-PJ. 2017. An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. Developmental Cell. 43(2), 198–211."},"intvolume":"        43","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["1534-5807"]},"page":"198 - 211","volume":43,"abstract":[{"lang":"eng","text":"Cell-cell contact formation constitutes an essential step in evolution, leading to the differentiation of specialized cell types. However, remarkably little is known about whether and how the interplay between contact formation and fate specification affects development. Here, we identify a positive feedback loop between cell-cell contact duration, morphogen signaling, and mesendoderm cell-fate specification during zebrafish gastrulation. We show that long-lasting cell-cell contacts enhance the competence of prechordal plate (ppl) progenitor cells to respond to Nodal signaling, required for ppl cell-fate specification. We further show that Nodal signaling promotes ppl cell-cell contact duration, generating a positive feedback loop between ppl cell-cell contact duration and cell-fate specification. Finally, by combining mathematical modeling and experimentation, we show that this feedback determines whether anterior axial mesendoderm cells become ppl or, instead, turn into endoderm. Thus, the interdependent activities of cell-cell signaling and contact formation control fate diversification within the developing embryo."}],"type":"journal_article","author":[{"last_name":"Barone","first_name":"Vanessa","id":"419EECCC-F248-11E8-B48F-1D18A9856A87","full_name":"Barone, Vanessa","orcid":"0000-0003-2676-3367"},{"full_name":"Lang, Moritz","id":"29E0800A-F248-11E8-B48F-1D18A9856A87","last_name":"Lang","first_name":"Moritz"},{"first_name":"Gabriel","last_name":"Krens","orcid":"0000-0003-4761-5996","id":"2B819732-F248-11E8-B48F-1D18A9856A87","full_name":"Krens, Gabriel"},{"first_name":"Saurabh","last_name":"Pradhan","full_name":"Pradhan, Saurabh"},{"last_name":"Shamipour","first_name":"Shayan","full_name":"Shamipour, Shayan","id":"40B34FE2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sako, Keisuke","id":"3BED66BE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6453-8075","first_name":"Keisuke","last_name":"Sako"},{"last_name":"Sikora","first_name":"Mateusz K","id":"2F74BCDE-F248-11E8-B48F-1D18A9856A87","full_name":"Sikora, Mateusz K"},{"full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","first_name":"Calin C","last_name":"Guet"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"_id":"735","month":"10","day":"23","publist_id":"6934","publication_status":"published","department":[{"_id":"CaHe"},{"_id":"CaGu"},{"_id":"GaTk"}],"issue":"2","article_processing_charge":"No","isi":1,"publication":"Developmental Cell","fulldoi":"https://doi.org/10.1016/j.devcel.2017.09.014","scopus_import":"1"}]