[{"isi":1,"title":"Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling","date_updated":"2026-04-22T22:30:58Z","month":"02","department":[{"_id":"AnKi"},{"_id":"EdHa"},{"_id":"NanoFab"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publisher":"Elsevier","publication_identifier":{"issn":["1534-5807"]},"article_processing_charge":"Yes (via OA deal)","doi":"10.1016/j.devcel.2024.10.024","publication_status":"published","year":"2025","date_published":"2025-02-24T00:00:00Z","citation":{"ista":"Rus S, Brückner D, Minchington T, Greunz M, Merrin J, Hannezo EB, Kicheva A. 2025. Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling. Developmental Cell. 60(4), 567–580.","ieee":"S. Rus <i>et al.</i>, “Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling,” <i>Developmental Cell</i>, vol. 60, no. 4. Elsevier, pp. 567–580, 2025.","mla":"Rus, Stefanie, et al. “Self-Organized Pattern Formation in the Developing Mouse Neural Tube by a Temporal Relay of BMP Signaling.” <i>Developmental Cell</i>, vol. 60, no. 4, Elsevier, 2025, pp. 567–80, doi:<a href=\"https://doi.org/10.1016/j.devcel.2024.10.024\">10.1016/j.devcel.2024.10.024</a>.","short":"S. Rus, D. Brückner, T. Minchington, M. Greunz, J. Merrin, E.B. Hannezo, A. Kicheva, Developmental Cell 60 (2025) 567–580.","apa":"Rus, S., Brückner, D., Minchington, T., Greunz, M., Merrin, J., Hannezo, E. B., &#38; Kicheva, A. (2025). Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2024.10.024\">https://doi.org/10.1016/j.devcel.2024.10.024</a>","ama":"Rus S, Brückner D, Minchington T, et al. Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling. <i>Developmental Cell</i>. 2025;60(4):567-580. doi:<a href=\"https://doi.org/10.1016/j.devcel.2024.10.024\">10.1016/j.devcel.2024.10.024</a>","chicago":"Rus, Stefanie, David Brückner, Thomas Minchington, Martina Greunz, Jack Merrin, Edouard B Hannezo, and Anna Kicheva. “Self-Organized Pattern Formation in the Developing Mouse Neural Tube by a Temporal Relay of BMP Signaling.” <i>Developmental Cell</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.devcel.2024.10.024\">https://doi.org/10.1016/j.devcel.2024.10.024</a>."},"OA_type":"hybrid","article_type":"original","abstract":[{"lang":"eng","text":"Developing tissues interpret dynamic changes in morphogen activity to generate cell type diversity. To quantitatively study bone morphogenetic protein (BMP) signaling dynamics in the mouse neural tube, we developed an embryonic stem cell differentiation system tailored for growing tissues. Differentiating cells form striking self-organized patterns of dorsal neural tube cell types driven by sequential phases of BMP signaling that are observed both in vitro and in vivo. Data-driven biophysical modeling showed that these dynamics result from coupling fast negative feedback with slow positive regulation of signaling by the specification of an endogenous BMP source. Thus, in contrast to relays that propagate morphogen signaling in space, we identify a BMP signaling relay that operates in time. This mechanism allows for a rapid initial concentration-sensitive response that is robustly terminated, thereby regulating balanced sequential cell type generation. Our study provides an experimental and theoretical framework to understand how signaling dynamics are exploited in developing tissues."}],"quality_controlled":"1","external_id":{"isi":["001434279000001"],"pmid":["39603235"]},"project":[{"grant_number":"101044579","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa","name":"Mechanisms of tissue size regulation in spinal cord development"},{"_id":"059DF620-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P02-Morphogen control of growth and pattern in the spinal cord","grant_number":"F7802"},{"name":"The regulatory logic of pattern formation in the vertebrate dorsal neural tube","_id":"9B9B39FA-BA93-11EA-9121-9846C619BF3A","grant_number":"SC19-011"}],"volume":60,"oa_version":"Published Version","day":"24","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"We thank A. Miller and N. Papalopulu for reagents and J. Briscoe for comments on the manuscript. Work in the A.K. lab is supported by ISTA; the European Research Council under Horizon Europe, grant 101044579; and the Austrian Science Fund (FWF), grant https://doi.org/10.55776/F78. S.L. is supported by Gesellschaft für Forschungsförderung Niederösterreich m.b.H. fellowship SC19-011. D.B.B. was supported by the NOMIS foundation as a NOMIS Fellow and by an EMBO Postdoctoral Fellowship (ALTF 343-2022).","author":[{"id":"4D9EC9B6-F248-11E8-B48F-1D18A9856A87","full_name":"Rus, Stefanie","last_name":"Rus","first_name":"Stefanie","orcid":"0000-0001-8703-1093"},{"first_name":"David","orcid":"0000-0001-7205-2975","last_name":"Brückner","id":"e1e86031-6537-11eb-953a-f7ab92be508d","full_name":"Brückner, David"},{"full_name":"Minchington, Thomas","id":"7d1648cb-19e9-11eb-8e7a-f8c037fb3e3f","last_name":"Minchington","first_name":"Thomas"},{"first_name":"Martina","full_name":"Greunz, Martina","id":"48A59534-F248-11E8-B48F-1D18A9856A87","last_name":"Greunz"},{"id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack","last_name":"Merrin","first_name":"Jack","orcid":"0000-0001-5145-4609"},{"first_name":"Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B"},{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","full_name":"Kicheva, Anna","last_name":"Kicheva","orcid":"0000-0003-4509-4998","first_name":"Anna"}],"type":"journal_article","corr_author":"1","issue":"4","file_date_updated":"2025-04-16T10:54:07Z","_id":"18807","OA_place":"publisher","related_material":{"record":[{"status":"public","id":"19763","relation":"dissertation_contains"}]},"oa":1,"page":"567-580","intvolume":"        60","pmid":1,"ddc":["570"],"file":[{"checksum":"bb58db4a908a1f4aabe4004706154541","date_created":"2025-04-16T10:54:07Z","file_size":6994499,"relation":"main_file","success":1,"access_level":"open_access","content_type":"application/pdf","date_updated":"2025-04-16T10:54:07Z","file_name":"2025_DevelopmentalCell_Lehr.pdf","file_id":"19584","creator":"dernst"}],"publication":"Developmental Cell","language":[{"iso":"eng"}],"has_accepted_license":"1","scopus_import":"1","date_created":"2025-01-09T11:25:47Z","status":"public"},{"doi":"10.15479/AT-ISTA-19386","article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","publication_identifier":{"isbn":["9783990780534"],"eissn":["2663-337X"]},"degree_awarded":"PhD","publication_status":"published","citation":{"short":"M.N. Elkrewi, Evolution of Sex Chromosomes, Sex Determination and Asexuality in Artemia Brine Shrimp, Institute of Science and Technology Austria, 2025.","apa":"Elkrewi, M. N. (2025). <i>Evolution of sex chromosomes, sex determination and asexuality in Artemia brine shrimp</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19386\">https://doi.org/10.15479/AT-ISTA-19386</a>","ama":"Elkrewi MN. Evolution of sex chromosomes, sex determination and asexuality in Artemia brine shrimp. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19386\">10.15479/AT-ISTA-19386</a>","chicago":"Elkrewi, Marwan N. “Evolution of Sex Chromosomes, Sex Determination and Asexuality in Artemia Brine Shrimp.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19386\">https://doi.org/10.15479/AT-ISTA-19386</a>.","ista":"Elkrewi MN. 2025. Evolution of sex chromosomes, sex determination and asexuality in Artemia brine shrimp. Institute of Science and Technology Austria.","ieee":"M. N. Elkrewi, “Evolution of sex chromosomes, sex determination and asexuality in Artemia brine shrimp,” Institute of Science and Technology Austria, 2025.","mla":"Elkrewi, Marwan N. <i>Evolution of Sex Chromosomes, Sex Determination and Asexuality in Artemia Brine Shrimp</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19386\">10.15479/AT-ISTA-19386</a>."},"year":"2025","date_published":"2025-03-14T00:00:00Z","title":"Evolution of sex chromosomes, sex determination and asexuality in Artemia brine shrimp","month":"03","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"date_updated":"2026-04-16T12:20:41Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"alternative_title":["ISTA Thesis"],"project":[{"grant_number":"F8810","name":"The highjacking of meiosis for asexual reproduction","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396"}],"oa_version":"Published Version","day":"14","OA_embargo":"12","abstract":[{"text":"Crustaceans are a large group of arthropods with a great diversity of species and\r\ndifferent types of sex determination systems and reproductive modes (Subramoniam, 2017).\r\nThis makes them a great model for exploring the evolution of sex chromosomes and sexual\r\ndimorphism and investigating the evolutionary mechanisms driving and maintaining the\r\ndiversity of reproductive systems. Within this taxon, Brine shrimp of the genus Artemia, a\r\nbranchiopod crustacean, are well suited for such explorations, as they have both highly\r\ndimorphic traits and closely related sexual and asexual species. Although brine shrimp are\r\nknown to have ZW sex chromosomes (Bowen, 1963; Parraguez et al., 2009), the sex\r\nchromosomes are still not well characterized at the genomic level, the sex-determination gene\r\nis unknown, and it is still unclear whether the same sex chromosomes as shared by the\r\ndifferent species.\r\nThe first part of this thesis was to characterize the Z and W chromosomes in Artemia\r\nusing an array of methods, from generating multiple chromosome and contig level genome\r\nassemblies to identifying W-linked scaffolds and transcripts in multiple species using k-mer\r\nbased approaches.\r\nThe second part tackles the conservation of the cell type specific regulatory pathways\r\nin the female reproductive system between Artemia and Drosophila, and the expression of the\r\nZ-specific region throughout meiosis using single-nucleus RNA-seq data. Our results show\r\nthat germline cells lack dosage compensation, with a subset of cells showing evidence of\r\nextreme repression of the Z chromosome.\r\nWith multiple sexual species and several asexual lineages of parthenogenetic females\r\nthat produce rare males at low frequencies, Brine shrimp present the perfect opportunity to\r\nexplore the transition to asexuality and shed light on the prerequisites and repercussions of\r\nthe form of modified meiosis maintaining the asexual lineages. The last chapter is an\r\ninvestigation of the molecular pathways involved in asexual reproduction in Artemia using\r\nnewly generated single nucleus RNAseq and WGS data and previously published data. ","lang":"eng"}],"OA_place":"publisher","_id":"19386","related_material":{"record":[{"relation":"part_of_dissertation","id":"12248","status":"public"},{"id":"10167","status":"public","relation":"part_of_dissertation"},{"status":"public","id":"10767","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"15009"},{"relation":"part_of_dissertation","status":"public","id":"14613"},{"relation":"part_of_dissertation","status":"public","id":"17890"}]},"oa":1,"type":"dissertation","acknowledgement":"My PhD work was funded by the Austrian science fund (FWF), as part of the SFB Meiosis consortium (https://sfbmeiosis.org/, grant ID FWF SFB F88-10).","author":[{"last_name":"Elkrewi","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","full_name":"Elkrewi, Marwan N","orcid":"0000-0002-5328-7231","first_name":"Marwan N"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","corr_author":"1","file_date_updated":"2026-03-26T23:30:03Z","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"ScienComp"}],"has_accepted_license":"1","date_created":"2025-03-11T12:54:31Z","status":"public","supervisor":[{"orcid":"0000-0002-4579-8306","first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso"}],"page":"170","ddc":["570","576"],"file":[{"checksum":"5549a8216c07e4c39281648912d72246","date_created":"2025-03-26T07:06:56Z","relation":"source_file","file_size":25019680,"access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"Thesis_Marwan_Elkrewi.docx","date_updated":"2026-03-26T23:30:03Z","creator":"melkrewi","file_id":"19462","embargo_to":"open_access"},{"access_level":"open_access","relation":"main_file","file_size":17294844,"date_created":"2025-03-26T07:06:22Z","checksum":"aed2ba9965aa89b3414deae1ae9f4321","file_id":"19463","creator":"melkrewi","date_updated":"2026-03-26T23:30:03Z","file_name":"Thesis_Marwan_Elkrewi.pdf","embargo":"2026-03-26","content_type":"application/pdf"}]},{"related_material":{"record":[{"status":"public","id":"6609","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","status":"public","id":"8529"},{"relation":"part_of_dissertation","status":"public","id":"18953"},{"relation":"part_of_dissertation","id":"10924","status":"public"},{"id":"9114","status":"public","relation":"part_of_dissertation"},{"id":"13200","status":"public","relation":"part_of_dissertation"}]},"oa":1,"_id":"18871","OA_place":"publisher","corr_author":"1","file_date_updated":"2026-01-29T23:30:03Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by the European Research Council under grant agreement no. 758053\r\n(ERC StG QUNNECT) and the European Union’s Horizon 2020 research, innovation program\r\nunder grant agreement no. 899354 (FETopen SuperQuLAN) and the Austrian Science Fund\r\n(FWF) through BeyondC (F7105). I want to acknowledge generous support from the Austrian\r\nAcademy of Sciences from a DOC [Doctoral program of the Austrian Academy of Sciences]\r\nfellowship (no. 25129).\r\n","author":[{"full_name":"Arnold, Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87","last_name":"Arnold","first_name":"Georg M","orcid":"0000-0003-1397-7876"}],"type":"dissertation","date_created":"2025-01-24T10:28:39Z","status":"public","supervisor":[{"last_name":"Fink","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8112-028X","first_name":"Johannes M"}],"language":[{"iso":"eng"}],"has_accepted_license":"1","acknowledged_ssus":[{"_id":"SSU"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"ddc":["530"],"file":[{"checksum":"71872702e8f46c275eaea44efc4d304f","date_created":"2025-01-29T08:38:08Z","file_size":18856130,"relation":"source_file","access_level":"closed","content_type":"application/x-zip-compressed","date_updated":"2026-01-29T23:30:03Z","file_name":"tex for upload.zip","embargo_to":"open_access","creator":"cchlebak","file_id":"18946"},{"date_updated":"2026-01-29T23:30:03Z","file_name":"ISTThesisGA2022_final.pdf","content_type":"application/pdf","embargo":"2026-01-29","creator":"cchlebak","file_id":"18947","date_created":"2025-01-29T08:38:34Z","checksum":"dfaa06591970f4bff163705802fad56d","access_level":"open_access","file_size":17344760,"relation":"main_file"}],"page":"135","year":"2025","date_published":"2025-01-24T00:00:00Z","citation":{"apa":"Arnold, G. M. (2025). <i>Microwave-optic interconnects for superconducting circuits</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:18871\">https://doi.org/10.15479/at:ista:18871</a>","short":"G.M. Arnold, Microwave-Optic Interconnects for Superconducting Circuits, Institute of Science and Technology Austria, 2025.","chicago":"Arnold, Georg M. “Microwave-Optic Interconnects for Superconducting Circuits.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/at:ista:18871\">https://doi.org/10.15479/at:ista:18871</a>.","ama":"Arnold GM. Microwave-optic interconnects for superconducting circuits. 2025. doi:<a href=\"https://doi.org/10.15479/at:ista:18871\">10.15479/at:ista:18871</a>","ista":"Arnold GM. 2025. Microwave-optic interconnects for superconducting circuits. Institute of Science and Technology Austria.","mla":"Arnold, Georg M. <i>Microwave-Optic Interconnects for Superconducting Circuits</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/at:ista:18871\">10.15479/at:ista:18871</a>.","ieee":"G. M. Arnold, “Microwave-optic interconnects for superconducting circuits,” Institute of Science and Technology Austria, 2025."},"publication_identifier":{"issn":["2663-337X"]},"publisher":"Institute of Science and Technology Austria","article_processing_charge":"No","doi":"10.15479/at:ista:18871","degree_awarded":"PhD","publication_status":"published","date_updated":"2026-04-16T12:20:43Z","department":[{"_id":"JoFi"},{"_id":"GradSch"}],"month":"01","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)"},"title":"Microwave-optic interconnects for superconducting circuits","ec_funded":1,"oa_version":"Published Version","day":"24","alternative_title":["ISTA Thesis"],"project":[{"_id":"26336814-B435-11E9-9278-68D0E5697425","name":"A Fiber Optic Transceiver for Superconducting Qubits","call_identifier":"H2020","grant_number":"758053"},{"grant_number":"899354","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","call_identifier":"H2020","name":"Quantum Local Area Networks with Superconducting Qubits"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"},{"grant_number":"F07105","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits"}],"abstract":[{"lang":"eng","text":"\"Can we do this with a new type of computer - a quantum computer?\". This famous\r\nquotation of the brilliant Richard Feynman within a conference talk on \"Simulating physics\r\nwith computers.” is often reverently praised as the origin of the field of quantum computing.\r\nThe idea was to use quantum mechanical systems itself to simulate \"Nature\", which is\r\ninherently quantum mechanical. Now, 43 years later, the theoretical framework of how such\r\na computer can operate has been developed. Two main important concepts for a potential\r\nquantum supremacy, superposition and entanglement, have been exploited to design quantum\r\nalgorithms to significantly speed up certain tasks. Yet, the specific hardware implementation\r\nis still far from being certain, in fact the race between the most promising platforms such as\r\nsuperconducting qubits, bosonic codes, cold atoms, trapped ions, optical computing as well\r\nas spin qubits has recently intensified. If one also includes the most mature applications of\r\nquantum communication technologies, secure quantum key distribution and quantum random\r\nnumber generators, as part of a quantum information technology ecosystem, we are confronted\r\nwith a plethora of different materials, concepts, and also operation frequencies. While\r\nsuperconducting qubits, bosonic codes and spin qubits work in the regime of approximately 5\r\nGHz and are controlled by electrical fields, trapped ions, cold atoms, and optical quantum\r\ncomputing operate with light in the infrared or visible range.\r\nConsequently, a quantum frequency converter or microwave-optic transducer is required\r\nto interface the different frequency domains or establish a long-range network connection\r\nwith suitable telecom fibers. In fact, the combination of different frequency regimes is also\r\nan essential part in our classical modern communication network, where computations are\r\nperformed in electrical circuits and the information exchange over longer distances happens\r\nvia optical fibers. However, the specific challenges specific to building a quantum computer,\r\nalso apply to the development of such a quantum frequency transducer: 1) As we deal with\r\nsingle excitations as the carrier of information, i.e. the smallest possible quantity, the signal\r\ncan easily be corrupted by other noise sources which needs to be avoided by all means. This\r\nis also the reason why microwave quantum computers operate at temperature environments\r\nclose to zero temperature (< 0.1 Kelvin) to avoid corruption by thermal noise. 2) The\r\nfrequency interface generally needs to preserve the phase of the signal as an essential part\r\nof the quantum state. And 3) Quantum signals cannot be copied which would be a typical\r\nstrategy to account for errors in classical computers. And finally, there is a challenge specific to\r\nmicrowave-optic transducers: While quantum computers are operating in one specific frequency\r\ndomain, microwave-optic transducers combine microwave and optical fields in one device.\r\nThis results in the particular challenge that high-energy optical radiation, which is usually\r\nwell-shielded from superconducting microwave quantum processors, are now an essential part\r\nof the device. The concomitant optical radiation in the operating transducer will inevitably\r\nhave a detrimental effect on the superconducting microwave components. Together with the\r\nrequirement of minimal background noise for quantum-limited operation as described above,\r\nv\r\nheating from the absorption of optical photons within the same device where single microwave\r\nexcitations are processed forms a formidable challenge.\r\nThis thesis aims to address this challenge by developing microwave-optic transducers where\r\nthe impact of optical absorption on superconducting circuits in general and superconducting\r\nqubits specifically can be mitigated. In our first approach, we developed a compact device\r\nwith optimized interaction strengths between the different frequency domains. This minimizes\r\nthe optical powers used for transducer operation and thus the optical absorption heating. This\r\nwork was - to the best of our knowledge - the first comprehensive noise study, in an integrated\r\nmicrowave-optic transducer. Unfortunately, we saw that the optical absorption heating added\r\nnoise way above a single excitation. Consequently, a potential quantum signal would have\r\nbeen buried in the noise, added by the transduction.\r\nBuilding on this insight, we utilized a three-dimensional microwave-optic transducer instead\r\nof an integrated device. The larger heat capacity of the macroscopic device with a size\r\nof a few millimeters can absorb a larger fraction of the optical heating before it increases\r\nthe temperature of the device. This allowed us to interface the transducer directly with a\r\nsuperconducting qubit to readout the qubit state in a novel all-optical manner. We showed\r\nthat the microwave-optic transducer can be operated in a regime in which optical fields don’t\r\nharm the sensitive qubit. This is an important prerequisite for the operation of microwave-optic\r\ntransducers in conjunction with microwave quantum processors and brings the integration and\r\nseamless orchestration of different frequency components in a quantum network a step closer.\r\n"}]},{"OA_type":"hybrid","abstract":[{"lang":"eng","text":"Recent advancements in superconducting circuits have enabled the experimental study of collective behavior of precisely controlled intermediate-scale ensembles of qubits. In this work, we demonstrate an atomic frequency comb formed by individual artificial atoms strongly coupled to a single resonator mode. We observe periodic microwave pulses that originate from a single coherent excitation dynamically interacting with the multiqubit ensemble. We show that this revival dynamics emerges as a consequence of the constructive and periodic rephasing of the five superconducting qubits forming the vacuum Rabi split comb. In the future, similar devices could be used as a memory with in situ tunable storage time or as an on-chip periodic pulse generator with nonclassical photon statistics."}],"article_type":"original","project":[{"name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","grant_number":"F07105"},{"_id":"26336814-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053"},{"_id":"26B354CA-B435-11E9-9278-68D0E5697425","name":"Controllable Collective States of Superconducting Qubit Ensembles"}],"external_id":{"isi":["001454696700003"],"arxiv":["2310.04200"],"pmid":["40021171"]},"quality_controlled":"1","day":"14","oa_version":"Published Version","volume":134,"ec_funded":1,"title":"Observation of collapse and revival in a superconducting atomic frequency comb","article_number":"063601","isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"JoFi"}],"month":"02","date_updated":"2026-04-22T22:31:08Z","publication_status":"published","doi":"10.1103/PhysRevLett.134.063601","publisher":"American Physical Society","publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"article_processing_charge":"Yes (via OA deal)","citation":{"short":"E. Redchenko, M. Zens, M. Zemlicka, M. Peruzzo, F. Hassani, R. Sett, P.D. Zielinski, H.S. Dhar, D.O. Krimer, S. Rotter, J.M. Fink, Physical Review Letters 134 (2025).","apa":"Redchenko, E., Zens, M., Zemlicka, M., Peruzzo, M., Hassani, F., Sett, R., … Fink, J. M. (2025). Observation of collapse and revival in a superconducting atomic frequency comb. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.134.063601\">https://doi.org/10.1103/PhysRevLett.134.063601</a>","ama":"Redchenko E, Zens M, Zemlicka M, et al. Observation of collapse and revival in a superconducting atomic frequency comb. <i>Physical Review Letters</i>. 2025;134(6). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.134.063601\">10.1103/PhysRevLett.134.063601</a>","chicago":"Redchenko, Elena, M. Zens, Martin Zemlicka, Matilda Peruzzo, Farid Hassani, Riya Sett, Przemyslaw D Zielinski, et al. “Observation of Collapse and Revival in a Superconducting Atomic Frequency Comb.” <i>Physical Review Letters</i>. American Physical Society, 2025. <a href=\"https://doi.org/10.1103/PhysRevLett.134.063601\">https://doi.org/10.1103/PhysRevLett.134.063601</a>.","ista":"Redchenko E, Zens M, Zemlicka M, Peruzzo M, Hassani F, Sett R, Zielinski PD, Dhar HS, Krimer DO, Rotter S, Fink JM. 2025. Observation of collapse and revival in a superconducting atomic frequency comb. Physical Review Letters. 134(6), 063601.","ieee":"E. Redchenko <i>et al.</i>, “Observation of collapse and revival in a superconducting atomic frequency comb,” <i>Physical Review Letters</i>, vol. 134, no. 6. American Physical Society, 2025.","mla":"Redchenko, Elena, et al. “Observation of Collapse and Revival in a Superconducting Atomic Frequency Comb.” <i>Physical Review Letters</i>, vol. 134, no. 6, 063601, American Physical Society, 2025, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.134.063601\">10.1103/PhysRevLett.134.063601</a>."},"year":"2025","date_published":"2025-02-14T00:00:00Z","intvolume":"       134","pmid":1,"file":[{"file_id":"19291","creator":"dernst","content_type":"application/pdf","date_updated":"2025-03-04T10:40:50Z","file_name":"2025_PhysReviewLetters_Redchenko.pdf","file_size":2080408,"relation":"main_file","success":1,"access_level":"open_access","checksum":"633d6c5ddd9b805da22c5839d3d48df6","date_created":"2025-03-04T10:40:50Z"}],"ddc":["530"],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"publication":"Physical Review Letters","date_created":"2025-03-02T23:01:52Z","status":"public","scopus_import":"1","type":"journal_article","author":[{"first_name":"Elena","full_name":"Redchenko, Elena","id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","last_name":"Redchenko"},{"first_name":"M.","last_name":"Zens","full_name":"Zens, M."},{"last_name":"Zemlicka","full_name":"Zemlicka, Martin","id":"2DCF8DE6-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","orcid":"0009-0005-0878-3032"},{"id":"3F920B30-F248-11E8-B48F-1D18A9856A87","full_name":"Peruzzo, Matilda","last_name":"Peruzzo","first_name":"Matilda","orcid":"0000-0002-3415-4628"},{"last_name":"Hassani","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","full_name":"Hassani, Farid","orcid":"0000-0001-6937-5773","first_name":"Farid"},{"first_name":"Riya","orcid":"0000-0001-7641-8348","full_name":"Sett, Riya","id":"2E6D040E-F248-11E8-B48F-1D18A9856A87","last_name":"Sett"},{"full_name":"Zielinski, Przemyslaw D","id":"e198fcc4-f6e0-11ea-865d-b6a256760ee8","last_name":"Zielinski","first_name":"Przemyslaw D"},{"last_name":"Dhar","full_name":"Dhar, H. S.","first_name":"H. S."},{"full_name":"Krimer, D. O.","last_name":"Krimer","first_name":"D. O."},{"first_name":"S.","last_name":"Rotter","full_name":"Rotter, S."},{"last_name":"Fink","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","first_name":"Johannes M"}],"acknowledgement":"The authors thank G. Arnold and R. Sahu for the discussions, L. Drmic for software development, the MIBA workshop and the ISTA nanofabrication facility for technical support, and VTT Technical Research Centre of Finland for providing us TWPAs for follow-up measurements. This work was supported by the Austrian Science Fund (FWF) [Grant DOI: 10.55776/F71] through BeyondC (F7105) and IST Austria. E. S. R. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J. M. F. and M. Ž. acknowledge support from the European Research Council under Grant Agreement No. 758053 (ERC StG QUNNECT) and a NOMIS foundation research grant.","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2025-03-04T10:40:50Z","issue":"6","corr_author":"1","OA_place":"publisher","_id":"19280","arxiv":1,"related_material":{"record":[{"relation":"dissertation_contains","id":"19533","status":"public"}]},"oa":1},{"abstract":[{"text":"This thesis explores advancements in quantum remote sensing and non-equilibrium phase\r\ntransitions in the microwave regime, with a focus on dissipative phase transitions and quantumenhanced sensing.\r\nIn the first project, I experimentally studied photon blockade breakdown as a dissipative phase\r\ntransition in a zero-dimensional cavity-qubit system. By defining an appropriate thermodynamic\r\nlimit, we demonstrated that the observed bistability is a genuine signature of a first-order\r\nphase transition in this system. This work provides insight into non-equilibrium quantum\r\ndynamics and phase transitions in driven-dissipative open quantum systems.\r\nThe second project focuses on the experimental realization of a phase-conjugate receiver for\r\nquantum illumination (QI), a quantum sensing protocol that enhances target detection in noisy\r\nenvironments using entangled light. While an ideal spontaneous parametric down-conversion\r\n(SPDC) source and receiver could, in theory, provide up to a 6 dB advantage over classical\r\nillumination, no such ideal receiver exists. Instead, we explore an experimental realization of a\r\nphase-conjugate receiver for QI in the microwave regime at millikelvin temperatures using a\r\nJosephson parametric converter (JPC) as a source of continuous-variable Gaussian entangled\r\nsignal-idler pairs, where a maximum 3 dB advantage is theoretically achievable. We investigate\r\nkey experimental limitations that constrain practical QI performance, contributing to the\r\ndevelopment of quantum-enhanced sensing.\r\nAdditionally, this thesis presents efficient digital signal processing (DSP) techniques implemented in C++ and Python in collaboration with Przemysław Zieliński and Luka Drmić. These\r\nmethods, optimized using the Intel Integrated Performance Primitives (IPP) library, have been\r\nessential in data acquisition, noise filtering, and correlation analysis across multiple research\r\nprojects. Although not real-time, these DSP techniques significantly enhance the accuracy of\r\nquantum measurements.\r\nOverall, this thesis advances quantum-enhanced sensing by establishing the thermodynamic\r\nlimit in a single transmon-cavity system and experimentally exploring a phase-conjugate receiver\r\nfor QI. These findings contribute to quantum metrology, particularly for weak signal detection\r\nand remote sensing in noisy environments.\r\n","lang":"eng"}],"project":[{"_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020","name":"Quantum readout techniques and technologies","grant_number":"862644"},{"grant_number":"F07105","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f"}],"alternative_title":["ISTA Thesis"],"oa_version":"Published Version","day":"1","ec_funded":1,"title":" Quantum remote sensing and non-equilibrium phase transitions in the microwave regime","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_updated":"2026-04-16T12:20:42Z","month":"04","department":[{"_id":"GradSch"},{"_id":"JoFi"}],"degree_awarded":"PhD","publication_status":"published","publisher":"Institute of Science and Technology Austria","publication_identifier":{"issn":["2663-337X"]},"article_processing_charge":"No","doi":"10.15479/AT-ISTA-19533","date_published":"2025-04-01T00:00:00Z","year":"2025","citation":{"mla":"Sett, Riya. <i> Quantum Remote Sensing and Non-Equilibrium Phase Transitions in the Microwave Regime</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19533\">10.15479/AT-ISTA-19533</a>.","ieee":"R. Sett, “ Quantum remote sensing and non-equilibrium phase transitions in the microwave regime,” Institute of Science and Technology Austria, 2025.","ista":"Sett R. 2025.  Quantum remote sensing and non-equilibrium phase transitions in the microwave regime. Institute of Science and Technology Austria.","chicago":"Sett, Riya. “ Quantum Remote Sensing and Non-Equilibrium Phase Transitions in the Microwave Regime.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19533\">https://doi.org/10.15479/AT-ISTA-19533</a>.","ama":"Sett R.  Quantum remote sensing and non-equilibrium phase transitions in the microwave regime. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19533\">10.15479/AT-ISTA-19533</a>","apa":"Sett, R. (2025). <i> Quantum remote sensing and non-equilibrium phase transitions in the microwave regime</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19533\">https://doi.org/10.15479/AT-ISTA-19533</a>","short":"R. Sett,  Quantum Remote Sensing and Non-Equilibrium Phase Transitions in the Microwave Regime, Institute of Science and Technology Austria, 2025."},"page":"109","file":[{"content_type":"application/pdf","embargo":"2025-10-11","file_name":"PhD_Thesis_Riya_Sett_pdfa.pdf","date_updated":"2025-10-11T22:30:02Z","creator":"rsett","file_id":"19538","checksum":"ba6cd2289d0141a160a14fc97df1632f","date_created":"2025-04-10T11:33:22Z","file_size":4129208,"relation":"main_file","access_level":"open_access"},{"relation":"source_file","file_size":6646110,"access_level":"closed","checksum":"ee63a94cb8f7adf5e766903028b81ed6","date_created":"2025-04-10T11:34:08Z","creator":"rsett","embargo_to":"open_access","file_id":"19539","content_type":"application/x-zip-compressed","date_updated":"2025-10-11T22:30:02Z","file_name":"PhD Thesis Riya Sett.zip"}],"ddc":["530"],"has_accepted_license":"1","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"LifeSc"},{"_id":"SSU"}],"language":[{"iso":"eng"}],"supervisor":[{"last_name":"Fink","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","orcid":"0000-0001-8112-028X"}],"date_created":"2025-04-09T16:44:26Z","status":"public","keyword":["phase transition","open quantum system","phase diagram","cavity quantum electrodynamics","superconducting qubits","semiclassical physics","quantum optics","josephson junction","parametric converter","phase conjugation","quantum radar","quantum entanglement","correlation","quantum sensing"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"I acknowledge the generous financial support of the Austrian Science Fund (FWF) via BeyondC\r\n(F7105) and the European Union’s Horizon 2020 research and innovation program (FETopen\r\nQUARTET, Grant Agreement No. 862644), which made this research possible. I also extend\r\nmy sincere appreciation to the MIBA workshop and the Institute of Science and Technology\r\nAustria nanofabrication facility for their technical assistance, which was instrumental in realizing\r\nthis work.","author":[{"first_name":"Riya","orcid":"0000-0001-7641-8348","last_name":"Sett","full_name":"Sett, Riya","id":"2E6D040E-F248-11E8-B48F-1D18A9856A87"}],"type":"dissertation","file_date_updated":"2025-10-11T22:30:02Z","corr_author":"1","_id":"19533","OA_place":"publisher","oa":1,"related_material":{"record":[{"relation":"research_data","id":"18978","status":"public"},{"status":"public","id":"19280","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"13117","status":"public"},{"relation":"part_of_dissertation","status":"public","id":"17183"}]}},{"day":"24","oa_version":"Published Version","volume":16,"project":[{"grant_number":"101069515","_id":"34c0acea-11ca-11ed-8bc3-8775e10fd452","name":"Integrated Germanium Quantum Technology"},{"grant_number":"F8606","_id":"34a66131-11ca-11ed-8bc3-a31681c6b03e","name":"Center for Correlated Quantum Materials and Solid State Quantum Systems: Conventional  and unconventional topological superconductors"},{"name":"High impedance circuit quantum electrodynamics with hole spins","_id":"c0977eea-5a5b-11eb-8a69-a862db0cf4d1","grant_number":"I05060"},{"_id":"262116AA-B435-11E9-9278-68D0E5697425","name":"Hybrid Semiconductor - Superconductor Quantum Devices"}],"quality_controlled":"1","external_id":{"pmid":["40274808"],"arxiv":["2408.03224"],"isi":["001475587400022"]},"abstract":[{"text":"Hole spin qubits are rapidly emerging as the workhorse of semiconducting quantum processors because of their large spin-orbit interaction, enabling fast all-electric operations at low power. However, spin-orbit interaction also causes non-uniformities in devices, resulting in locally varying qubit energies and site-dependent anisotropies. While these anisotropies can be used to drive single-spins, if not properly harnessed, they can hinder the path toward large-scale quantum processors. Here, we report on microwave-driven singlet-triplet qubits in planar germanium and use them to investigate the anisotropy of two spins in a double quantum dot. We show two distinct operating regimes depending on the magnetic field direction. For in-plane fields, the two spins are largely anisotropic, and electrically tunable, which enables to measure all the available transitions; coherence times exceeding 3 $\\mu$s are extracted. For out-of-plane fields, they have an isotropic response but preserve the substantial energy difference required to address the singlet-triplet qubit. Even in this field direction, where the qubit lifetime\r\nis strongly affected by nuclear spins, we find 400 ns coherence times. Our work adds a valuable tool to investigate and harness the anisotropy of spin qubits and can be implemented in any large-scale NxN device, facilitating the path towards scalable quantum processors.","lang":"eng"}],"article_type":"original","OA_type":"gold","citation":{"mla":"Saez Mollejo, Jaime, et al. “Exchange Anisotropies in Microwave-Driven Singlet-Triplet Qubits.” <i>Nature Communications</i>, vol. 16, 3862, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-58969-y\">10.1038/s41467-025-58969-y</a>.","ieee":"J. Saez Mollejo <i>et al.</i>, “Exchange anisotropies in microwave-driven singlet-triplet qubits,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ista":"Saez Mollejo J, Jirovec D, Schell YA, Kukucka J, Calcaterra S, Chrastina D, Isella G, Rimbach-Russ M, Bosco S, Katsaros G. 2025. Exchange anisotropies in microwave-driven singlet-triplet qubits. Nature Communications. 16, 3862.","chicago":"Saez Mollejo, Jaime, Daniel Jirovec, Yona A Schell, Josip Kukucka, Stefano Calcaterra, Daniel Chrastina, Giovanni Isella, Maximilian Rimbach-Russ, Stefano Bosco, and Georgios Katsaros. “Exchange Anisotropies in Microwave-Driven Singlet-Triplet Qubits.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-58969-y\">https://doi.org/10.1038/s41467-025-58969-y</a>.","ama":"Saez Mollejo J, Jirovec D, Schell YA, et al. Exchange anisotropies in microwave-driven singlet-triplet qubits. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-58969-y\">10.1038/s41467-025-58969-y</a>","apa":"Saez Mollejo, J., Jirovec, D., Schell, Y. A., Kukucka, J., Calcaterra, S., Chrastina, D., … Katsaros, G. (2025). Exchange anisotropies in microwave-driven singlet-triplet qubits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-58969-y\">https://doi.org/10.1038/s41467-025-58969-y</a>","short":"J. Saez Mollejo, D. Jirovec, Y.A. Schell, J. Kukucka, S. Calcaterra, D. Chrastina, G. Isella, M. Rimbach-Russ, S. Bosco, G. Katsaros, Nature Communications 16 (2025)."},"year":"2025","date_published":"2025-04-24T00:00:00Z","publication_status":"published","doi":"10.1038/s41467-025-58969-y","publication_identifier":{"eissn":["2041-1723"]},"publisher":"Springer Nature","article_processing_charge":"Yes","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"GeKa"}],"month":"04","date_updated":"2026-04-22T22:31:09Z","title":"Exchange anisotropies in microwave-driven singlet-triplet qubits","isi":1,"article_number":"3862","status":"public","scopus_import":"1","date_created":"2025-03-19T13:28:12Z","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"publication":"Nature Communications","file":[{"date_updated":"2025-05-05T07:08:23Z","file_name":"2025_NatureComm_SaezMollejo.pdf","content_type":"application/pdf","file_id":"19645","creator":"dernst","date_created":"2025-05-05T07:08:23Z","checksum":"13fe84cddc9d4e47213bf17acdac70d7","success":1,"access_level":"open_access","file_size":1548756,"relation":"main_file"}],"ddc":["530"],"intvolume":"        16","pmid":1,"oa":1,"related_material":{"record":[{"relation":"research_data","id":"19409","status":"public"},{"status":"public","id":"19836","relation":"dissertation_contains"}]},"OA_place":"publisher","_id":"19424","DOAJ_listed":"1","arxiv":1,"file_date_updated":"2025-05-05T07:08:23Z","corr_author":"1","type":"journal_article","acknowledgement":"We thank A. Crippa for helpful discussions. This research was supported by the Scientific Service Units of ISTA through resources provided by the MIBA Machine Shop and the Nanofabrication facility. This research and related results were made possible with the support of the NOMIS Foundation, the HORIZON-RIA 101069515 project and the FWF Projects with DOI:10.55776/F86 and DOI:10.55776/I5060. M.R.-R. acknowledges support from the Netherlands Organization of Scientific Research (NWO) under Veni grant VI.Veni.212.223. The\r\nResearch of S.B. and M.R.-R. was sponsored in part by the Army Research Office and was accomplished under Award Number: W911NF-23-1-0110. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Office or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein.","author":[{"first_name":"Jaime","last_name":"Saez Mollejo","id":"e0390f72-f6e0-11ea-865d-862393336714","full_name":"Saez Mollejo, Jaime"},{"first_name":"Daniel","orcid":"0000-0002-7197-4801","full_name":"Jirovec, Daniel","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","last_name":"Jirovec"},{"first_name":"Yona A","last_name":"Schell","full_name":"Schell, Yona A","id":"fe39122d-06bb-11ec-a33b-9e22b40e40a5"},{"first_name":"Josip","last_name":"Kukucka","id":"3F5D8856-F248-11E8-B48F-1D18A9856A87","full_name":"Kukucka, Josip"},{"first_name":"Stefano","last_name":"Calcaterra","full_name":"Calcaterra, Stefano"},{"full_name":"Chrastina, Daniel","last_name":"Chrastina","first_name":"Daniel"},{"first_name":"Giovanni","full_name":"Isella, Giovanni","last_name":"Isella"},{"full_name":"Rimbach-Russ, Maximilian","last_name":"Rimbach-Russ","first_name":"Maximilian"},{"last_name":"Bosco","full_name":"Bosco, Stefano","first_name":"Stefano"},{"id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios","last_name":"Katsaros","orcid":"0000-0001-8342-202X","first_name":"Georgios"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"author":[{"last_name":"Saez Mollejo","full_name":"Saez Mollejo, Jaime","id":"e0390f72-f6e0-11ea-865d-862393336714","first_name":"Jaime"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"This research was supported by the Scientific Service Units of ISTA through resources provided\r\nby the MIBA Machine Shop and the Nanofabrication facility. We acknowledge the support from\r\nthe European Commission with the project Integrated Germanium Quantum Technology (with\r\nDOI:10.3030/101069515), the NOMIS Foundation, the HORIZON-RIA 101069515 project and\r\nthe FWF Projects Center for Correlated Quantum Materials and Solid State Quantum Systems:\r\nConventional and unconventional topological superconductors (with DOI:10.55776/F86) and\r\nHigh impedance circuit quantum electrodynamics with hole spins (with DOI:10.55776/I5060).\r\n","type":"dissertation","file_date_updated":"2026-04-01T22:30:07Z","corr_author":"1","_id":"19836","OA_place":"publisher","oa":1,"related_material":{"record":[{"status":"public","id":"19424","relation":"part_of_dissertation"}]},"page":"175","file":[{"content_type":"application/x-zip-compressed","file_name":"istaustriathesis-master - Copy.zip","date_updated":"2026-04-01T22:30:07Z","creator":"jsaezmol","file_id":"19849","embargo_to":"open_access","checksum":"643bfddead59857536cce4d57c775b32","date_created":"2025-06-16T09:38:49Z","relation":"source_file","file_size":59892829,"access_level":"closed"},{"checksum":"e3dcb767fcc2b1787a455fdda991cefb","date_created":"2025-06-18T08:50:16Z","relation":"main_file","file_size":22382376,"access_level":"open_access","embargo":"2026-04-01","content_type":"application/pdf","file_name":"SaezMollejo_PhDFinal_pdfa-1b.pdf","date_updated":"2026-04-01T22:30:07Z","file_id":"19851","creator":"jsaezmol"}],"ddc":["530","539"],"acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"M-Shop"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"supervisor":[{"orcid":"0000-0001-8342-202X","first_name":"Georgios","last_name":"Katsaros","full_name":"Katsaros, Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87"}],"date_created":"2025-06-13T09:01:50Z","status":"public","title":"Singlet-triplet qubits in planar Germanium : From exchange anisotropies to autonomous tuning ","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_updated":"2026-04-17T07:50:20Z","month":"06","department":[{"_id":"GradSch"},{"_id":"GeKa"}],"degree_awarded":"PhD","publication_status":"published","publication_identifier":{"issn":["2663-337X"]},"article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","doi":"10.15479/AT-ISTA-19836","year":"2025","date_published":"2025-06-13T00:00:00Z","citation":{"apa":"Saez Mollejo, J. (2025). <i>Singlet-triplet qubits in planar Germanium : From exchange anisotropies to autonomous tuning </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-19836\">https://doi.org/10.15479/AT-ISTA-19836</a>","short":"J. Saez Mollejo, Singlet-Triplet Qubits in Planar Germanium : From Exchange Anisotropies to Autonomous Tuning , Institute of Science and Technology Austria, 2025.","chicago":"Saez Mollejo, Jaime. “Singlet-Triplet Qubits in Planar Germanium : From Exchange Anisotropies to Autonomous Tuning .” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-19836\">https://doi.org/10.15479/AT-ISTA-19836</a>.","ama":"Saez Mollejo J. Singlet-triplet qubits in planar Germanium : From exchange anisotropies to autonomous tuning . 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19836\">10.15479/AT-ISTA-19836</a>","ista":"Saez Mollejo J. 2025. Singlet-triplet qubits in planar Germanium : From exchange anisotropies to autonomous tuning . Institute of Science and Technology Austria.","mla":"Saez Mollejo, Jaime. <i>Singlet-Triplet Qubits in Planar Germanium : From Exchange Anisotropies to Autonomous Tuning </i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-19836\">10.15479/AT-ISTA-19836</a>.","ieee":"J. Saez Mollejo, “Singlet-triplet qubits in planar Germanium : From exchange anisotropies to autonomous tuning ,” Institute of Science and Technology Austria, 2025."},"abstract":[{"text":"Over the past century, researchers have been fascinated by the quantum nature of the\r\nphysical world, initially striving to understand its fundamental principles and consequences, and\r\neventually progressing toward engineering systems that can control and manipulate quantum\r\nproperties. Today, we stand at the dawn of the quantum technology era. While some quantum\r\ntechnologies follow well-defined roadmaps, others are still in the exciting and uncertain early\r\nstages of development. In the fields of quantum computing and quantum simulation, research\r\nis being conducted across a wide variety of platforms. Each of these demonstrates control over\r\nquantum properties but also faces challenges in scaling up to the level of a mature technology.\r\nThis thesis explores some of the fundamental properties of hole spin qubits in planar germanium.\r\nSemiconductor spin qubits are considered strong candidates for the realization of quantum\r\nprocessors, owing to their long relaxation and coherence times, as well as their compatibility\r\nwith existing semiconductor industry infrastructure. Among these, hole spin qubits in planar\r\ngermanium are particularly promising. Their advantages include a large effective mass, which\r\neases fabrication constraints; inherent protection from hyperfine noise; and strong spin-orbit\r\ninteraction, which enables fast and purely electrical control. However, spin-orbit coupling also\r\nintroduces site-dependent variability across qubits, particularly in the g-tensors and spin-flip\r\ntunneling, which might cause that the quantization axes are not aligned. In this thesis, we\r\ninvestigate the tilt between the quantization axes of two hole spins hosted in a double quantum\r\ndot as a function of both the magnetic field direction and various electrostatic configurations,\r\ndemonstrating that both parameters influence this tilt. We conclude by introducing a machine-learning-assisted routine to automatically tune baseband spin qubits. This approach may prove\r\nto be a powerful tool for characterizing spin-orbit effects and gaining deeper insight into the\r\nphysics governing spin qubit behavior.\r\n","lang":"eng"}],"project":[{"grant_number":"101069515","_id":"34c0acea-11ca-11ed-8bc3-8775e10fd452","name":"Integrated Germanium Quantum Technology"},{"grant_number":"F8606","name":"Center for Correlated Quantum Materials and Solid State Quantum Systems: Conventional  and unconventional topological superconductors","_id":"34a66131-11ca-11ed-8bc3-a31681c6b03e"},{"name":"High impedance circuit quantum electrodynamics with hole spins","_id":"c0977eea-5a5b-11eb-8a69-a862db0cf4d1","grant_number":"I05060"}],"alternative_title":["ISTA Thesis"],"oa_version":"Published Version","day":"13"},{"keyword":["Applied Mathematics","Modeling and Simulation","Statistics and Probability"],"status":"public","scopus_import":"1","date_created":"2023-01-12T12:12:29Z","has_accepted_license":"1","publication":"Stochastics and Partial Differential Equations: Analysis and Computations","language":[{"iso":"eng"}],"file":[{"success":1,"access_level":"open_access","file_size":1206413,"relation":"main_file","date_created":"2024-07-22T09:29:48Z","checksum":"59c9000761134d681bdf9d482664044c","creator":"dernst","file_id":"17297","date_updated":"2024-07-22T09:29:48Z","file_name":"2024_StochasticsEquations_Agresti.pdf","content_type":"application/pdf"}],"ddc":["510"],"intvolume":"        12","page":"53-133","oa":1,"_id":"12178","arxiv":1,"file_date_updated":"2024-07-22T09:29:48Z","acknowledgement":"The authors thank the anonymous referees for their helpful comments and suggestions. Open Access funding enabled and organized by Projekt DEAL.","author":[{"last_name":"Agresti","full_name":"Agresti, Antonio","id":"673cd0cc-9b9a-11eb-b144-88f30e1fbb72","orcid":"0000-0002-9573-2962","first_name":"Antonio"},{"full_name":"Hieber, Matthias","last_name":"Hieber","first_name":"Matthias"},{"last_name":"Hussein","full_name":"Hussein, Amru","first_name":"Amru"},{"full_name":"Saal, Martin","last_name":"Saal","first_name":"Martin"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","volume":12,"day":"01","oa_version":"Published Version","external_id":{"isi":["000874389000001"],"arxiv":["2109.09561"]},"quality_controlled":"1","abstract":[{"lang":"eng","text":"In this paper we consider the stochastic primitive equation for geophysical flows subject to transport noise and turbulent pressure. Admitting very rough noise terms, the global existence and uniqueness of solutions to this stochastic partial differential equation are proven using stochastic maximal L² regularity, the theory of critical spaces for stochastic evolution equations, and global a priori bounds. Compared to other results in this direction, we do not need any smallness assumption on the transport noise which acts directly on the velocity field and we also allow rougher noise terms. The adaptation to Stratonovich type noise and, more generally, to variable viscosity and/or conductivity are discussed as well."}],"article_type":"original","date_published":"2024-03-01T00:00:00Z","year":"2024","citation":{"ista":"Agresti A, Hieber M, Hussein A, Saal M. 2024. The stochastic primitive equations with transport noise and turbulent pressure. Stochastics and Partial Differential Equations: Analysis and Computations. 12, 53–133.","mla":"Agresti, Antonio, et al. “The Stochastic Primitive Equations with Transport Noise and Turbulent Pressure.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 12, Springer Nature, 2024, pp. 53–133, doi:<a href=\"https://doi.org/10.1007/s40072-022-00277-3\">10.1007/s40072-022-00277-3</a>.","ieee":"A. Agresti, M. Hieber, A. Hussein, and M. Saal, “The stochastic primitive equations with transport noise and turbulent pressure,” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 12. Springer Nature, pp. 53–133, 2024.","apa":"Agresti, A., Hieber, M., Hussein, A., &#38; Saal, M. (2024). The stochastic primitive equations with transport noise and turbulent pressure. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40072-022-00277-3\">https://doi.org/10.1007/s40072-022-00277-3</a>","short":"A. Agresti, M. Hieber, A. Hussein, M. Saal, Stochastics and Partial Differential Equations: Analysis and Computations 12 (2024) 53–133.","chicago":"Agresti, Antonio, Matthias Hieber, Amru Hussein, and Martin Saal. “The Stochastic Primitive Equations with Transport Noise and Turbulent Pressure.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s40072-022-00277-3\">https://doi.org/10.1007/s40072-022-00277-3</a>.","ama":"Agresti A, Hieber M, Hussein A, Saal M. The stochastic primitive equations with transport noise and turbulent pressure. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. 2024;12:53-133. doi:<a href=\"https://doi.org/10.1007/s40072-022-00277-3\">10.1007/s40072-022-00277-3</a>"},"publication_status":"published","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"eissn":["2194-041X"],"issn":["2194-0401"]},"publisher":"Springer Nature","doi":"10.1007/s40072-022-00277-3","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_updated":"2024-07-22T09:30:40Z","month":"03","department":[{"_id":"JuFi"}],"title":"The stochastic primitive equations with transport noise and turbulent pressure","isi":1},{"article_processing_charge":"No","publisher":"Springer Nature","publication_identifier":{"issn":["0179-5376"],"eissn":["1432-0444"]},"doi":"10.1007/s00454-023-00532-x","publication_status":"published","date_published":"2024-09-01T00:00:00Z","year":"2024","citation":{"apa":"Fulek, R., Gärtner, B., Kupavskii, A., Valtr, P., &#38; Wagner, U. (2024). The crossing Tverberg theorem. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-023-00532-x\">https://doi.org/10.1007/s00454-023-00532-x</a>","short":"R. Fulek, B. Gärtner, A. Kupavskii, P. Valtr, U. Wagner, Discrete and Computational Geometry 72 (2024) 831–848.","chicago":"Fulek, Radoslav, Bernd Gärtner, Andrey Kupavskii, Pavel Valtr, and Uli Wagner. “The Crossing Tverberg Theorem.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00454-023-00532-x\">https://doi.org/10.1007/s00454-023-00532-x</a>.","ama":"Fulek R, Gärtner B, Kupavskii A, Valtr P, Wagner U. The crossing Tverberg theorem. <i>Discrete and Computational Geometry</i>. 2024;72:831-848. doi:<a href=\"https://doi.org/10.1007/s00454-023-00532-x\">10.1007/s00454-023-00532-x</a>","ista":"Fulek R, Gärtner B, Kupavskii A, Valtr P, Wagner U. 2024. The crossing Tverberg theorem. Discrete and Computational Geometry. 72, 831–848.","mla":"Fulek, Radoslav, et al. “The Crossing Tverberg Theorem.” <i>Discrete and Computational Geometry</i>, vol. 72, Springer Nature, 2024, pp. 831–48, doi:<a href=\"https://doi.org/10.1007/s00454-023-00532-x\">10.1007/s00454-023-00532-x</a>.","ieee":"R. Fulek, B. Gärtner, A. Kupavskii, P. Valtr, and U. Wagner, “The crossing Tverberg theorem,” <i>Discrete and Computational Geometry</i>, vol. 72. Springer Nature, pp. 831–848, 2024."},"isi":1,"title":"The crossing Tverberg theorem","date_updated":"2025-04-14T13:52:36Z","department":[{"_id":"UlWa"}],"month":"09","external_id":{"arxiv":["1812.04911"],"isi":["001038546500001"]},"quality_controlled":"1","project":[{"call_identifier":"FWF","name":"Eliminating intersections in drawings of graphs","_id":"261FA626-B435-11E9-9278-68D0E5697425","grant_number":"M02281"}],"volume":72,"oa_version":"Preprint","day":"01","OA_type":"green","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.1812.04911"}],"abstract":[{"lang":"eng","text":"The Tverberg theorem is one of the cornerstones of discrete geometry. It states that, given a set X of at least (d+1)(r−1)+1 points in Rd, one can find a partition X=X1∪⋯∪Xr of X, such that the convex hulls of the Xi, i=1,…,r, all share a common point. In this paper, we prove a trengthening of this theorem that guarantees a partition which, in addition to the above, has the property that the boundaries of full-dimensional convex hulls have pairwise nonempty intersections. Possible generalizations and algorithmic aspects are also discussed. As a concrete application, we show that any n points in the plane in general position span ⌊n/3⌋ vertex-disjoint triangles that are pairwise crossing, meaning that their boundaries have pairwise nonempty intersections; this number is clearly best possible. A previous result of Álvarez-Rebollar et al. guarantees ⌊n/6⌋pairwise crossing triangles. Our result generalizes to a result about simplices in Rd, d≥2."}],"arxiv":1,"_id":"13974","OA_place":"repository","oa":1,"related_material":{"record":[{"relation":"earlier_version","status":"public","id":"6647"}]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"id":"39F3FFE4-F248-11E8-B48F-1D18A9856A87","full_name":"Fulek, Radoslav","last_name":"Fulek","first_name":"Radoslav","orcid":"0000-0001-8485-1774"},{"first_name":"Bernd","last_name":"Gärtner","full_name":"Gärtner, Bernd"},{"first_name":"Andrey","last_name":"Kupavskii","full_name":"Kupavskii, Andrey"},{"first_name":"Pavel","last_name":"Valtr","full_name":"Valtr, Pavel"},{"last_name":"Wagner","full_name":"Wagner, Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1494-0568","first_name":"Uli"}],"acknowledgement":"Part of the research leading to this paper was done during the 16th Gremo Workshop on Open Problems (GWOP), Waltensburg, Switzerland, June 12–16, 2018. We thank Patrick Schnider for suggesting the problem, and Stefan Felsner, Malte Milatz, and Emo Welzl for fruitful discussions during the workshop. We also thank Stefan Felsner and Manfred Scheucher for finding, communicating the example from Sect. 3.3, and the kind permission to include their visualization of the point set. We thank Dömötör Pálvölgyi, the SoCG reviewers, and DCG reviewers for various helpful comments.\r\nR. Fulek gratefully acknowledges support from Austrian Science Fund (FWF), Project  M2281-N35. A. Kupavskii was supported by the Advanced Postdoc.Mobility Grant no. P300P2_177839 of the Swiss National Science Foundation. Research by P. Valtr was supported by the Grant no. 18-19158 S of the Czech Science Foundation (GAČR).","type":"journal_article","publication":"Discrete and Computational Geometry","language":[{"iso":"eng"}],"status":"public","scopus_import":"1","date_created":"2023-08-06T22:01:12Z","page":"831-848","intvolume":"        72"},{"file":[{"file_name":"2024_JourTheorProbab_Campbell.pdf","date_updated":"2024-07-22T09:41:21Z","content_type":"application/pdf","creator":"dernst","file_id":"17300","date_created":"2024-07-22T09:41:21Z","checksum":"f7793d313104c70422140c5e6494c779","success":1,"access_level":"open_access","relation":"main_file","file_size":555070}],"ddc":["510"],"page":"933-973","intvolume":"        37","status":"public","date_created":"2023-08-06T22:01:13Z","scopus_import":"1","has_accepted_license":"1","language":[{"iso":"eng"}],"publication":"Journal of Theoretical Probability","file_date_updated":"2024-07-22T09:41:21Z","corr_author":"1","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"The first author thanks Yizhe Zhu for pointing out reference [30]. We thank David Renfrew for comments on an earlier draft. We thank the anonymous referee for a careful reading and helpful comments.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria).","author":[{"first_name":"Andrew J","last_name":"Campbell","full_name":"Campbell, Andrew J","id":"582b06a9-1f1c-11ee-b076-82ffce00dde4"},{"last_name":"O’Rourke","full_name":"O’Rourke, Sean","first_name":"Sean"}],"oa":1,"_id":"13975","arxiv":1,"abstract":[{"text":"We consider the spectrum of random Laplacian matrices of the form Ln=An−Dn where An\r\n is a real symmetric random matrix and Dn is a diagonal matrix whose entries are equal to the corresponding row sums of An. If An is a Wigner matrix with entries in the domain of attraction of a Gaussian distribution, the empirical spectral measure of Ln is known to converge to the free convolution of a semicircle distribution and a standard real Gaussian distribution. We consider real symmetric random matrices An with independent entries (up to symmetry) whose row sums converge to a purely non-Gaussian infinitely divisible distribution, which fall into the class of Lévy–Khintchine random matrices first introduced by Jung [Trans Am Math Soc, 370, (2018)]. Our main result shows that the empirical spectral measure of Ln  converges almost surely to a deterministic limit. A key step in the proof is to use the purely non-Gaussian nature of the row sums to build a random operator to which Ln converges in an appropriate sense. This operator leads to a recursive distributional equation uniquely describing the Stieltjes transform of the limiting empirical spectral measure.","lang":"eng"}],"article_type":"original","volume":37,"oa_version":"Published Version","day":"01","external_id":{"arxiv":["2210.07927"],"isi":["001038341000001"]},"quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"LaEr"}],"month":"03","date_updated":"2024-07-22T09:41:42Z","title":"Spectrum of Lévy–Khintchine random laplacian matrices","isi":1,"citation":{"mla":"Campbell, Andrew J., and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” <i>Journal of Theoretical Probability</i>, vol. 37, Springer Nature, 2024, pp. 933–73, doi:<a href=\"https://doi.org/10.1007/s10959-023-01275-4\">10.1007/s10959-023-01275-4</a>.","ieee":"A. J. Campbell and S. O’Rourke, “Spectrum of Lévy–Khintchine random laplacian matrices,” <i>Journal of Theoretical Probability</i>, vol. 37. Springer Nature, pp. 933–973, 2024.","ista":"Campbell AJ, O’Rourke S. 2024. Spectrum of Lévy–Khintchine random laplacian matrices. Journal of Theoretical Probability. 37, 933–973.","chicago":"Campbell, Andrew J, and Sean O’Rourke. “Spectrum of Lévy–Khintchine Random Laplacian Matrices.” <i>Journal of Theoretical Probability</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10959-023-01275-4\">https://doi.org/10.1007/s10959-023-01275-4</a>.","ama":"Campbell AJ, O’Rourke S. Spectrum of Lévy–Khintchine random laplacian matrices. <i>Journal of Theoretical Probability</i>. 2024;37:933-973. doi:<a href=\"https://doi.org/10.1007/s10959-023-01275-4\">10.1007/s10959-023-01275-4</a>","apa":"Campbell, A. J., &#38; O’Rourke, S. (2024). Spectrum of Lévy–Khintchine random laplacian matrices. <i>Journal of Theoretical Probability</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10959-023-01275-4\">https://doi.org/10.1007/s10959-023-01275-4</a>","short":"A.J. Campbell, S. O’Rourke, Journal of Theoretical Probability 37 (2024) 933–973."},"date_published":"2024-03-01T00:00:00Z","year":"2024","publication_status":"published","doi":"10.1007/s10959-023-01275-4","publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0894-9840"],"eissn":["1572-9230"]}},{"date_published":"2024-01-03T00:00:00Z","oa":1,"year":"2024","citation":{"ama":"Lao D, Hu Z, Locatello F, Yang Y, Soatto S. Divided attention: Unsupervised multi-object discovery with contextually separated slots. In: <i>1st Conference on Parsimony and Learning</i>. ; 2024.","chicago":"Lao, Dong, Zhengyang Hu, Francesco Locatello, Yanchao Yang, and Stefano Soatto. “Divided Attention: Unsupervised Multi-Object Discovery with Contextually Separated Slots.” In <i>1st Conference on Parsimony and Learning</i>, 2024.","short":"D. Lao, Z. Hu, F. Locatello, Y. Yang, S. Soatto, in:, 1st Conference on Parsimony and Learning, 2024.","apa":"Lao, D., Hu, Z., Locatello, F., Yang, Y., &#38; Soatto, S. (2024). Divided attention: Unsupervised multi-object discovery with contextually separated slots. In <i>1st Conference on Parsimony and Learning</i>. Hong Kong, China.","ieee":"D. Lao, Z. Hu, F. Locatello, Y. Yang, and S. Soatto, “Divided attention: Unsupervised multi-object discovery with contextually separated slots,” in <i>1st Conference on Parsimony and Learning</i>, Hong Kong, China, 2024.","mla":"Lao, Dong, et al. “Divided Attention: Unsupervised Multi-Object Discovery with Contextually Separated Slots.” <i>1st Conference on Parsimony and Learning</i>, 2024.","ista":"Lao D, Hu Z, Locatello F, Yang Y, Soatto S. 2024. Divided attention: Unsupervised multi-object discovery with contextually separated slots. 1st Conference on Parsimony and Learning. CPAL: Conference on Parsimony and Learning."},"_id":"14213","publication_status":"published","article_processing_charge":"No","arxiv":1,"file_date_updated":"2024-02-12T08:40:36Z","date_updated":"2024-02-12T08:56:23Z","month":"01","department":[{"_id":"FrLo"}],"title":"Divided attention: Unsupervised multi-object discovery with contextually separated slots","author":[{"first_name":"Dong","full_name":"Lao, Dong","last_name":"Lao"},{"full_name":"Hu, Zhengyang","last_name":"Hu","first_name":"Zhengyang"},{"id":"26cfd52f-2483-11ee-8040-88983bcc06d4","full_name":"Locatello, Francesco","last_name":"Locatello","first_name":"Francesco","orcid":"0000-0002-4850-0683"},{"full_name":"Yang, Yanchao","last_name":"Yang","first_name":"Yanchao"},{"full_name":"Soatto, Stefano","last_name":"Soatto","first_name":"Stefano"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference","day":"03","oa_version":"Published Version","status":"public","date_created":"2023-08-22T14:19:59Z","quality_controlled":"1","external_id":{"arxiv":["2304.01430"]},"has_accepted_license":"1","publication":"1st Conference on Parsimony and Learning","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","date_updated":"2024-02-12T08:40:36Z","file_name":"2024_CPAL_Lao.pdf","file_id":"14978","creator":"dernst","checksum":"8fad894c34f1b3d5a14fb8ffb12f7277","date_created":"2024-02-12T08:40:36Z","file_size":8038511,"relation":"main_file","access_level":"open_access","success":1}],"abstract":[{"lang":"eng","text":"We introduce a method to segment the visual field into independently moving regions, trained with no ground truth or supervision. It consists of an adversarial conditional encoder-decoder architecture based on Slot Attention, modified to use the image as context to decode optical flow without attempting to reconstruct the image itself. In the resulting multi-modal representation, one modality (flow) feeds the encoder to produce separate latent codes (slots), whereas the other modality (image) conditions the decoder to generate the first (flow) from the slots. This design frees the representation from having to encode complex nuisance variability in the image due to, for instance, illumination and reflectance properties of the scene. Since customary autoencoding based on minimizing the reconstruction error does not preclude the entire flow from being encoded into a single slot, we modify the loss to an adversarial criterion based on Contextual Information Separation. The resulting min-max optimization fosters the separation of objects and their assignment to different attention slots, leading to Divided Attention, or DivA. DivA outperforms recent unsupervised multi-object motion segmentation methods while tripling run-time speed up to 104FPS and reducing the performance gap from supervised methods to 12% or less. DivA can handle different numbers of objects and different image sizes at training and test time, is invariant to permutation of object labels, and does not require explicit regularization."}],"ddc":["000"],"conference":{"location":"Hong Kong, China","start_date":"2024-01-03","name":"CPAL: Conference on Parsimony and Learning","end_date":"2024-01-03"}},{"ec_funded":1,"volume":5,"oa_version":"Published Version","day":"08","quality_controlled":"1","external_id":{"isi":["001158054500001"],"pmid":["37528584"]},"project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985"}],"article_type":"original","abstract":[{"text":"The phytohormone auxin and its directional transport through tissues play a fundamental role in development of higher plants. This polar auxin transport predominantly relies on PIN-FORMED (PIN) auxin exporters. Hence, PIN polarization is crucial for development, but its evolution during the rise of morphological complexity in land plants remains unclear. Here, we performed a cross-species investigation by observing the trafficking and localization of endogenous and exogenous PINs in two bryophytes, Physcomitrium patens and Marchantia polymorpha, and in the flowering plant Arabidopsis thaliana. We confirmed that the GFP fusion did not compromise the auxin export function of all examined PINs by using radioactive auxin export assay and by observing the phenotypic changes in transgenic bryophytes. Endogenous PINs polarize to filamentous apices, while exogenous Arabidopsis PINs distribute symmetrically on the membrane in both bryophytes. In Arabidopsis root epidermis, bryophytic PINs show no defined polarity. Pharmacological interference revealed a strong cytoskeleton dependence of bryophytic but not Arabidopsis PIN polarization. The divergence of PIN polarization and trafficking is also observed within the bryophyte clade and between tissues of individual species. These results collectively reveal a divergence of PIN trafficking and polarity mechanisms throughout land plant evolution and a co-evolution of PIN sequence-based and cell-based polarity mechanisms.","lang":"eng"}],"OA_type":"gold","year":"2024","date_published":"2024-01-08T00:00:00Z","citation":{"ista":"Tang H, Lu K, Zhang Y, Cheng Y, Tu S, Friml J. 2024. Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. Plant Communications. 5(1), 100669.","mla":"Tang, Han, et al. “Divergence of Trafficking and Polarization Mechanisms for PIN Auxin Transporters during Land Plant Evolution.” <i>Plant Communications</i>, vol. 5, no. 1, 100669, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xplc.2023.100669\">10.1016/j.xplc.2023.100669</a>.","ieee":"H. Tang, K. Lu, Y. Zhang, Y. Cheng, S. Tu, and J. Friml, “Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution,” <i>Plant Communications</i>, vol. 5, no. 1. Elsevier, 2024.","apa":"Tang, H., Lu, K., Zhang, Y., Cheng, Y., Tu, S., &#38; Friml, J. (2024). Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. <i>Plant Communications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xplc.2023.100669\">https://doi.org/10.1016/j.xplc.2023.100669</a>","short":"H. Tang, K. Lu, Y. Zhang, Y. Cheng, S. Tu, J. Friml, Plant Communications 5 (2024).","chicago":"Tang, Han, KJ Lu, Y Zhang, YL Cheng, SL Tu, and Jiří Friml. “Divergence of Trafficking and Polarization Mechanisms for PIN Auxin Transporters during Land Plant Evolution.” <i>Plant Communications</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xplc.2023.100669\">https://doi.org/10.1016/j.xplc.2023.100669</a>.","ama":"Tang H, Lu K, Zhang Y, Cheng Y, Tu S, Friml J. Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution. <i>Plant Communications</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xplc.2023.100669\">10.1016/j.xplc.2023.100669</a>"},"article_processing_charge":"Yes","publisher":"Elsevier","publication_identifier":{"issn":["2590-3462"]},"doi":"10.1016/j.xplc.2023.100669","publication_status":"published","date_updated":"2025-08-05T13:27:26Z","month":"01","department":[{"_id":"JiFr"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"isi":1,"article_number":"100669","title":"Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution","date_created":"2023-09-01T11:32:02Z","scopus_import":"1","status":"public","publication":"Plant Communications","language":[{"iso":"eng"}],"has_accepted_license":"1","ddc":["580"],"file":[{"file_id":"14911","creator":"dernst","date_updated":"2024-01-30T12:59:57Z","file_name":"2023_PlantCommunications_Tang.pdf","content_type":"application/pdf","success":1,"access_level":"open_access","relation":"main_file","file_size":2825565,"date_created":"2024-01-30T12:59:57Z","checksum":"edbc44c6d4a394d2bf70f92fdbb08f0a"}],"intvolume":"         5","pmid":1,"oa":1,"DOAJ_listed":"1","_id":"14251","OA_place":"publisher","corr_author":"1","issue":"1","file_date_updated":"2024-01-30T12:59:57Z","acknowledgement":"This work was supported by the ERC grant (PR1023ERC02) to H. T. and J. F., and by the ministry of science and technology (grant number 110-2636-B-005-001) to K. J. L.","author":[{"first_name":"Han","orcid":"0000-0001-6152-6637","full_name":"Tang, Han","id":"19BDF720-25A0-11EA-AC6E-928F3DDC885E","last_name":"Tang"},{"last_name":"Lu","full_name":"Lu, KJ","first_name":"KJ"},{"first_name":"Y","last_name":"Zhang","full_name":"Zhang, Y"},{"last_name":"Cheng","full_name":"Cheng, YL","first_name":"YL"},{"first_name":"SL","last_name":"Tu","full_name":"Tu, SL"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","orcid":"0000-0002-8302-7596"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article"},{"article_type":"original","abstract":[{"text":"For a locally finite set in R2, the order-k Brillouin tessellations form an infinite sequence of convex face-to-face tilings of the plane. If the set is coarsely dense and generic, then the corresponding infinite sequences of minimum and maximum angles are both monotonic in k. As an example, a stationary Poisson point process in R2  is locally finite, coarsely dense, and generic with probability one. For such a set, the distributions of angles in the Voronoi tessellations, Delaunay mosaics, and Brillouin tessellations are independent of the order and can be derived from the formula for angles in order-1 Delaunay mosaics given by Miles (Math. Biosci. 6, 85–127 (1970)).","lang":"eng"}],"quality_controlled":"1","external_id":{"isi":["001060727600004"],"arxiv":["2204.01076"],"pmid":["39610762"]},"project":[{"_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020","grant_number":"788183"},{"grant_number":"Z00342","_id":"268116B8-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Mathematics, Computer Science"},{"call_identifier":"FWF","name":"Persistence and stability of geometric complexes","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","grant_number":"I02979-N35"}],"ec_funded":1,"volume":72,"oa_version":"Published Version","day":"01","isi":1,"title":"On angles in higher order Brillouin tessellations and related tilings in the plane","date_updated":"2025-04-23T08:41:59Z","month":"07","department":[{"_id":"HeEd"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","doi":"10.1007/s00454-023-00566-1","publication_status":"published","date_published":"2024-07-01T00:00:00Z","year":"2024","citation":{"ama":"Edelsbrunner H, Garber A, Ghafari M, Heiss T, Saghafian M. On angles in higher order Brillouin tessellations and related tilings in the plane. <i>Discrete and Computational Geometry</i>. 2024;72:29-48. doi:<a href=\"https://doi.org/10.1007/s00454-023-00566-1\">10.1007/s00454-023-00566-1</a>","chicago":"Edelsbrunner, Herbert, Alexey Garber, Mohadese Ghafari, Teresa Heiss, and Morteza Saghafian. “On Angles in Higher Order Brillouin Tessellations and Related Tilings in the Plane.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00454-023-00566-1\">https://doi.org/10.1007/s00454-023-00566-1</a>.","short":"H. Edelsbrunner, A. Garber, M. Ghafari, T. Heiss, M. Saghafian, Discrete and Computational Geometry 72 (2024) 29–48.","apa":"Edelsbrunner, H., Garber, A., Ghafari, M., Heiss, T., &#38; Saghafian, M. (2024). On angles in higher order Brillouin tessellations and related tilings in the plane. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-023-00566-1\">https://doi.org/10.1007/s00454-023-00566-1</a>","ieee":"H. Edelsbrunner, A. Garber, M. Ghafari, T. Heiss, and M. Saghafian, “On angles in higher order Brillouin tessellations and related tilings in the plane,” <i>Discrete and Computational Geometry</i>, vol. 72. Springer Nature, pp. 29–48, 2024.","mla":"Edelsbrunner, Herbert, et al. “On Angles in Higher Order Brillouin Tessellations and Related Tilings in the Plane.” <i>Discrete and Computational Geometry</i>, vol. 72, Springer Nature, 2024, pp. 29–48, doi:<a href=\"https://doi.org/10.1007/s00454-023-00566-1\">10.1007/s00454-023-00566-1</a>.","ista":"Edelsbrunner H, Garber A, Ghafari M, Heiss T, Saghafian M. 2024. On angles in higher order Brillouin tessellations and related tilings in the plane. Discrete and Computational Geometry. 72, 29–48."},"page":"29-48","intvolume":"        72","pmid":1,"ddc":["510"],"file":[{"file_id":"17301","creator":"dernst","content_type":"application/pdf","file_name":"2024_DiscreteComputGeom_Edelsbrunner.pdf","date_updated":"2024-07-22T09:43:19Z","file_size":892019,"relation":"main_file","success":1,"access_level":"open_access","checksum":"b207b4e00f904e8ea8a30e24f0251f79","date_created":"2024-07-22T09:43:19Z"}],"publication":"Discrete and Computational Geometry","language":[{"iso":"eng"}],"has_accepted_license":"1","scopus_import":"1","date_created":"2023-09-17T22:01:10Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"first_name":"Alexey","last_name":"Garber","full_name":"Garber, Alexey"},{"first_name":"Mohadese","full_name":"Ghafari, Mohadese","last_name":"Ghafari"},{"full_name":"Heiss, Teresa","id":"4879BB4E-F248-11E8-B48F-1D18A9856A87","last_name":"Heiss","first_name":"Teresa","orcid":"0000-0002-1780-2689"},{"id":"f86f7148-b140-11ec-9577-95435b8df824","full_name":"Saghafian, Morteza","last_name":"Saghafian","first_name":"Morteza"}],"acknowledgement":"Work by all authors but A. Garber is supported by the European Research Council (ERC), Grant No. 788183, by the Wittgenstein Prize, Austrian Science Fund (FWF), Grant No. Z 342-N31, and by the DFG Collaborative Research Center TRR 109, Austrian Science Fund (FWF), Grant No. I 02979-N35. Work by A. Garber is partially supported by the Alexander von Humboldt Foundation.","type":"journal_article","corr_author":"1","file_date_updated":"2024-07-22T09:43:19Z","arxiv":1,"_id":"14345","oa":1},{"publication_status":"published","doi":"10.1016/j.nahs.2023.101430","article_processing_charge":"Yes (in subscription journal)","publisher":"Elsevier","publication_identifier":{"issn":["1751-570X"]},"citation":{"short":"R. Majumdar, K. Mallik, A.K. Schmuck, S. Soudjani, Nonlinear Analysis: Hybrid Systems 51 (2024).","apa":"Majumdar, R., Mallik, K., Schmuck, A. K., &#38; Soudjani, S. (2024). Symbolic control for stochastic systems via finite parity games. <i>Nonlinear Analysis: Hybrid Systems</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.nahs.2023.101430\">https://doi.org/10.1016/j.nahs.2023.101430</a>","ama":"Majumdar R, Mallik K, Schmuck AK, Soudjani S. Symbolic control for stochastic systems via finite parity games. <i>Nonlinear Analysis: Hybrid Systems</i>. 2024;51(2). doi:<a href=\"https://doi.org/10.1016/j.nahs.2023.101430\">10.1016/j.nahs.2023.101430</a>","chicago":"Majumdar, Rupak, Kaushik Mallik, Anne Kathrin Schmuck, and Sadegh Soudjani. “Symbolic Control for Stochastic Systems via Finite Parity Games.” <i>Nonlinear Analysis: Hybrid Systems</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.nahs.2023.101430\">https://doi.org/10.1016/j.nahs.2023.101430</a>.","ista":"Majumdar R, Mallik K, Schmuck AK, Soudjani S. 2024. Symbolic control for stochastic systems via finite parity games. Nonlinear Analysis: Hybrid Systems. 51(2), 101430.","ieee":"R. Majumdar, K. Mallik, A. K. Schmuck, and S. Soudjani, “Symbolic control for stochastic systems via finite parity games,” <i>Nonlinear Analysis: Hybrid Systems</i>, vol. 51, no. 2. Elsevier, 2024.","mla":"Majumdar, Rupak, et al. “Symbolic Control for Stochastic Systems via Finite Parity Games.” <i>Nonlinear Analysis: Hybrid Systems</i>, vol. 51, no. 2, 101430, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.nahs.2023.101430\">10.1016/j.nahs.2023.101430</a>."},"date_published":"2024-02-01T00:00:00Z","year":"2024","title":"Symbolic control for stochastic systems via finite parity games","isi":1,"article_number":"101430","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"month":"02","department":[{"_id":"ToHe"}],"date_updated":"2025-04-14T07:55:55Z","project":[{"_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020","grant_number":"101020093"}],"quality_controlled":"1","external_id":{"isi":["001093188100001"],"arxiv":["2101.00834"]},"day":"01","oa_version":"Published Version","volume":51,"ec_funded":1,"abstract":[{"text":"We consider the problem of computing the maximal probability of satisfying an \r\n-regular specification for stochastic, continuous-state, nonlinear systems evolving in discrete time. The problem reduces, after automata-theoretic constructions, to finding the maximal probability of satisfying a parity condition on a (possibly hybrid) state space. While characterizing the exact satisfaction probability is open, we show that a lower bound on this probability can be obtained by (I) computing an under-approximation of the qualitative winning region, i.e., states from which the parity condition can be enforced almost surely, and (II) computing the maximal probability of reaching this qualitative winning region.\r\nThe heart of our approach is a technique to symbolically compute the under-approximation of the qualitative winning region in step (I) via a finite-state abstraction of the original system as a \r\n-player parity game. Our abstraction procedure uses only the support of the probabilistic evolution; it does not use precise numerical transition probabilities. We prove that the winning set in the abstract -player game induces an under-approximation of the qualitative winning region in the original synthesis problem, along with a policy to solve it. By combining these contributions with (a) a symbolic fixpoint algorithm to solve \r\n-player games and (b) existing techniques for reachability policy synthesis in stochastic nonlinear systems, we get an abstraction-based algorithm for finding a lower bound on the maximal satisfaction probability.\r\nWe have implemented the abstraction-based algorithm in Mascot-SDS, where we combined the outlined abstraction step with our tool Genie (Majumdar et al., 2023) that solves \r\n-player parity games (through a reduction to Rabin games) more efficiently than existing algorithms. We evaluated our implementation on the nonlinear model of a perturbed bistable switch from the literature. We show empirically that the lower bound on the winning region computed by our approach is precise, by comparing against an over-approximation of the qualitative winning region. Moreover, our implementation outperforms a recently proposed tool for solving this problem by a large margin.","lang":"eng"}],"article_type":"original","_id":"14400","arxiv":1,"oa":1,"type":"journal_article","acknowledgement":"We thank Daniel Hausmann and Nir Piterman for their valuable comments on an earlier version of the manuscript of our other paper [22] where we present, among other things, the parity fixpoint for 2 1/2-player games (for a slightly more general class of games) with a different and indirect proof of correctness. Based on their comments we observed that, unlike the other fixpoints that we present in [22], the parity fixpoint does not follow the exact same structure as its counterpart for 2-player games, which we also use int his paper.\r\nWe also thank Thejaswini Raghavan for observing that our symbolic parity fixpoint algorithm can be solved in quasi-polynomial time using recent improved algorithms for solving \r\n-calculus expressions. This significantly improved the complexity bounds of our algorithm in this paper.\r\nThe work of R. Majumdar and A.-K. Schmuck are partially supported by DFG, Germany project 389792660 TRR 248–CPEC. A.-K. Schmuck is additionally funded through DFG, Germany project (SCHM 3541/1-1). K. Mallik is supported by the ERC project ERC-2020-AdG 101020093. S. Soudjani is supported by the following projects: EPSRC EP/V043676/1, EIC 101070802, and ERC 101089047.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Rupak","full_name":"Majumdar, Rupak","last_name":"Majumdar"},{"last_name":"Mallik","id":"0834ff3c-6d72-11ec-94e0-b5b0a4fb8598","full_name":"Mallik, Kaushik","first_name":"Kaushik","orcid":"0000-0001-9864-7475"},{"first_name":"Anne Kathrin","full_name":"Schmuck, Anne Kathrin","last_name":"Schmuck"},{"first_name":"Sadegh","full_name":"Soudjani, Sadegh","last_name":"Soudjani"}],"file_date_updated":"2024-07-16T10:26:41Z","issue":"2","corr_author":"1","has_accepted_license":"1","language":[{"iso":"eng"}],"publication":"Nonlinear Analysis: Hybrid Systems","date_created":"2023-10-08T22:01:15Z","status":"public","scopus_import":"1","intvolume":"        51","file":[{"creator":"dernst","file_id":"17258","date_updated":"2024-07-16T10:26:41Z","file_name":"2024_NonlinearAnalysis_Majumdar.pdf","content_type":"application/pdf","success":1,"access_level":"open_access","relation":"main_file","file_size":1787569,"date_created":"2024-07-16T10:26:41Z","checksum":"4eab70274d1004ea411f7f0e74c033ac"}],"ddc":["000"]},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2210.12060"}],"abstract":[{"text":"We prove that the mesoscopic linear statistics ∑if(na(σi−z0)) of the eigenvalues {σi}i of large n×n non-Hermitian random matrices with complex centred i.i.d. entries are asymptotically Gaussian for any H20-functions f around any point z0 in the bulk of the spectrum on any mesoscopic scale 0<a<1/2. This extends our previous result (Cipolloni et al. in Commun Pure Appl Math, 2019. arXiv:1912.04100), that was valid on the macroscopic scale, a=0\r\n, to cover the entire mesoscopic regime. The main novelty is a local law for the product of resolvents for the Hermitization of X at spectral parameters z1,z2 with an improved error term in the entire mesoscopic regime |z1−z2|≫n−1/2. The proof is dynamical; it relies on a recursive tandem of the characteristic flow method and the Green function comparison idea combined with a separation of the unstable mode of the underlying stability operator.","lang":"eng"}],"article_type":"original","volume":188,"oa_version":"Preprint","day":"01","ec_funded":1,"quality_controlled":"1","external_id":{"arxiv":["2210.12060"],"isi":["001118972500001"]},"project":[{"grant_number":"101020331","name":"Random matrices beyond Wigner-Dyson-Mehta","call_identifier":"H2020","_id":"62796744-2b32-11ec-9570-940b20777f1d"}],"date_updated":"2025-08-05T13:28:15Z","department":[{"_id":"LaEr"}],"month":"04","title":"Mesoscopic central limit theorem for non-Hermitian random matrices","isi":1,"date_published":"2024-04-01T00:00:00Z","year":"2024","citation":{"ama":"Cipolloni G, Erdös L, Schröder DJ. Mesoscopic central limit theorem for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. 2024;188:1131-1182. doi:<a href=\"https://doi.org/10.1007/s00440-023-01229-1\">10.1007/s00440-023-01229-1</a>","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00440-023-01229-1\">https://doi.org/10.1007/s00440-023-01229-1</a>.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields 188 (2024) 1131–1182.","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2024). Mesoscopic central limit theorem for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00440-023-01229-1\">https://doi.org/10.1007/s00440-023-01229-1</a>","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Mesoscopic central limit theorem for non-Hermitian random matrices,” <i>Probability Theory and Related Fields</i>, vol. 188. Springer Nature, pp. 1131–1182, 2024.","mla":"Cipolloni, Giorgio, et al. “Mesoscopic Central Limit Theorem for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>, vol. 188, Springer Nature, 2024, pp. 1131–82, doi:<a href=\"https://doi.org/10.1007/s00440-023-01229-1\">10.1007/s00440-023-01229-1</a>.","ista":"Cipolloni G, Erdös L, Schröder DJ. 2024. Mesoscopic central limit theorem for non-Hermitian random matrices. Probability Theory and Related Fields. 188, 1131–1182."},"publication_status":"published","publisher":"Springer Nature","article_processing_charge":"No","publication_identifier":{"eissn":["1432-2064"],"issn":["0178-8051"]},"doi":"10.1007/s00440-023-01229-1","page":"1131-1182","intvolume":"       188","scopus_import":"1","status":"public","date_created":"2023-10-08T22:01:17Z","publication":"Probability Theory and Related Fields","language":[{"iso":"eng"}],"acknowledgement":"The authors are grateful to Joscha Henheik for his help with the formulas in Appendix B.\r\nLászló Erdős supported by ERC Advanced Grant “RMTBeyond” No. 101020331. Dominik Schröder supported by the SNSF Ambizione Grant PZ00P2 209089.","author":[{"first_name":"Giorgio","orcid":"0000-0002-4901-7992","last_name":"Cipolloni","full_name":"Cipolloni, Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Erdös","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László"},{"first_name":"Dominik J","orcid":"0000-0002-2904-1856","full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","last_name":"Schröder"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","oa":1,"_id":"14408","arxiv":1},{"article_number":"2305128","isi":1,"title":"A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries","department":[{"_id":"MaIb"}],"month":"01","date_updated":"2025-04-15T06:36:40Z","doi":"10.1002/adma.202305128","article_processing_charge":"No","publication_identifier":{"eissn":["1521-4095"],"issn":["0935-9648"]},"publisher":"Wiley","publication_status":"published","citation":{"ama":"Zeng G, Sun Q, Horta S, et al. A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. <i>Advanced Materials</i>. 2024;36(1). doi:<a href=\"https://doi.org/10.1002/adma.202305128\">10.1002/adma.202305128</a>","chicago":"Zeng, Guifang, Qing Sun, Sharona Horta, Shang Wang, Xuan Lu, Chaoyue Zhang, Jing Li, et al. “A Layered Bi2Te3@PPy Cathode for Aqueous Zinc Ion Batteries: Mechanism and Application in Printed Flexible Batteries.” <i>Advanced Materials</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/adma.202305128\">https://doi.org/10.1002/adma.202305128</a>.","short":"G. Zeng, Q. Sun, S. Horta, S. Wang, X. Lu, C. Zhang, J. Li, J. Li, L. Ci, Y. Tian, M. Ibáñez, A. Cabot, Advanced Materials 36 (2024).","apa":"Zeng, G., Sun, Q., Horta, S., Wang, S., Lu, X., Zhang, C., … Cabot, A. (2024). A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. <i>Advanced Materials</i>. Wiley. <a href=\"https://doi.org/10.1002/adma.202305128\">https://doi.org/10.1002/adma.202305128</a>","ieee":"G. Zeng <i>et al.</i>, “A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries,” <i>Advanced Materials</i>, vol. 36, no. 1. Wiley, 2024.","mla":"Zeng, Guifang, et al. “A Layered Bi2Te3@PPy Cathode for Aqueous Zinc Ion Batteries: Mechanism and Application in Printed Flexible Batteries.” <i>Advanced Materials</i>, vol. 36, no. 1, 2305128, Wiley, 2024, doi:<a href=\"https://doi.org/10.1002/adma.202305128\">10.1002/adma.202305128</a>.","ista":"Zeng G, Sun Q, Horta S, Wang S, Lu X, Zhang C, Li J, Li J, Ci L, Tian Y, Ibáñez M, Cabot A. 2024. A layered Bi2Te3@PPy cathode for aqueous zinc ion batteries: Mechanism and application in printed flexible batteries. Advanced Materials. 36(1), 2305128."},"year":"2024","date_published":"2024-01-04T00:00:00Z","article_type":"original","abstract":[{"text":"Low‐cost, safe, and environmental‐friendly rechargeable aqueous zinc‐ion batteries (ZIBs) are promising as next‐generation energy storage devices for wearable electronics among other applications. However, sluggish ionic transport kinetics and the unstable electrode structure during ionic insertion/extraction hampers their deployment. Herein,  we propose a new cathode material based on a layered metal chalcogenide (LMC), bismuth telluride (Bi<jats:sub>2</jats:sub>Te<jats:sub>3</jats:sub>), coated with polypyrrole (PPy). Taking advantage of the PPy coating, the Bi<jats:sub>2</jats:sub>Te<jats:sub>3</jats:sub>@PPy composite presents strong ionic absorption affinity, high oxidation resistance, and high structural stability. The ZIBs based on Bi<jats:sub>2</jats:sub>Te<jats:sub>3</jats:sub>@PPy cathodes exhibit high capacities and ultra‐long lifespans of over 5000 cycles. They also present outstanding stability even under bending. In addition,  we analyze here the reaction mechanism using in situ X‐ray diffraction, X‐ray photoelectron spectroscopy, and computational tools and demonstrate that, in the aqueous system, Zn<jats:sup>2+</jats:sup> is not inserted into the cathode as previously assumed. In contrast, proton charge storage dominates the process. Overall, this work not only shows the great potential of LMCs as ZIBs cathode materials and the advantages of PPy coating, but also clarifies the charge/discharge mechanism in rechargeable ZIBs based on LMCs.","lang":"eng"}],"project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"quality_controlled":"1","external_id":{"pmid":["37555532"],"isi":["001085681000001"]},"oa_version":"None","volume":36,"day":"04","type":"journal_article","acknowledgement":"G.Z. and Q.S. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (52105329, 52175300) and the Heilongjiang Provincial Natural Science Foundation of China (LH2022E059). G.Z., X.L., and C.Z. thank the China Scholarship Council (CSC) for the scholarship support. This research was supported by the Scientific Service Units of ISTA through resources provided by the Electron Microscopy Facility. S.H. and M.I. acknowledge funding by ISTA and Werner Siemens.","author":[{"first_name":"Guifang","full_name":"Zeng, Guifang","last_name":"Zeng"},{"first_name":"Qing","last_name":"Sun","full_name":"Sun, Qing"},{"full_name":"Horta, Sharona","id":"03a7e858-01b1-11ec-8b71-99ae6c4a05bc","last_name":"Horta","first_name":"Sharona"},{"full_name":"Wang, Shang","last_name":"Wang","first_name":"Shang"},{"first_name":"Xuan","last_name":"Lu","full_name":"Lu, Xuan"},{"last_name":"Zhang","full_name":"Zhang, Chaoyue","first_name":"Chaoyue"},{"last_name":"Li","full_name":"Li, Jing","first_name":"Jing"},{"last_name":"Li","full_name":"Li, Junshan","first_name":"Junshan"},{"first_name":"Lijie","last_name":"Ci","full_name":"Ci, Lijie"},{"first_name":"Yanhong","last_name":"Tian","full_name":"Tian, Yanhong"},{"last_name":"Ibáñez","full_name":"Ibáñez, Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","orcid":"0000-0001-5013-2843"},{"first_name":"Andreu","full_name":"Cabot, Andreu","last_name":"Cabot"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"1","_id":"14435","intvolume":"        36","pmid":1,"language":[{"iso":"eng"}],"publication":"Advanced Materials","acknowledged_ssus":[{"_id":"EM-Fac"}],"status":"public","scopus_import":"1","date_created":"2023-10-17T10:53:56Z","keyword":["Mechanical Engineering","Mechanics of Materials","General Materials Science"]},{"abstract":[{"lang":"eng","text":"Auxin belongs among major phytohormones and governs multiple aspects of plant growth and development. The establishment of auxin concentration gradients, determines, among other processes, plant organ positioning and growth responses to environmental stimuli.\r\nHerein we report the synthesis of new NBD- or DNS-labelled IAA derivatives and the elucidation of their biological activity, fluorescence properties and subcellular accumulation patterns in planta. These novel compounds did not show auxin-like activity, but instead antagonized physiological auxin effects. The DNS-labelled derivatives FL5 and FL6 showed strong anti-auxin activity in roots and hypocotyls, which also occurred at the level of gene transcription as confirmed by quantitative PCR analysis. The auxin antagonism of our derivatives was further demonstrated in vitro using an SPR-based binding assay. The NBD-labelled compound FL4 with the best fluorescence properties proved to be unsuitable to study auxin accumulation patterns in planta. On the other hand, the strongest anti-auxin activity possessing compounds FL5 and FL6 could be useful to study binding mechanisms to auxin receptors and for manipulations of auxin-regulated processes."}],"article_type":"original","day":"01","oa_version":"Published Version","volume":102,"external_id":{"isi":["001084334300001"]},"quality_controlled":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_updated":"2024-07-16T08:13:39Z","month":"04","department":[{"_id":"JiFr"}],"title":"New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana","isi":1,"date_published":"2024-04-01T00:00:00Z","year":"2024","citation":{"ista":"Bieleszová K, Hladík P, Kubala M, Napier R, Brunoni F, Gelová Z, Fiedler L, Kulich I, Strnad M, Doležal K, Novák O, Friml J, Žukauskaitė A. 2024. New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. Plant Growth Regulation. 102, 589–602.","ieee":"K. Bieleszová <i>et al.</i>, “New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana,” <i>Plant Growth Regulation</i>, vol. 102. Springer Nature, pp. 589–602, 2024.","mla":"Bieleszová, Kristýna, et al. “New Fluorescent Auxin Derivatives: Anti-Auxin Activity and Accumulation Patterns in Arabidopsis Thaliana.” <i>Plant Growth Regulation</i>, vol. 102, Springer Nature, 2024, pp. 589–602, doi:<a href=\"https://doi.org/10.1007/s10725-023-01083-0\">10.1007/s10725-023-01083-0</a>.","short":"K. Bieleszová, P. Hladík, M. Kubala, R. Napier, F. Brunoni, Z. Gelová, L. Fiedler, I. Kulich, M. Strnad, K. Doležal, O. Novák, J. Friml, A. Žukauskaitė, Plant Growth Regulation 102 (2024) 589–602.","apa":"Bieleszová, K., Hladík, P., Kubala, M., Napier, R., Brunoni, F., Gelová, Z., … Žukauskaitė, A. (2024). New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. <i>Plant Growth Regulation</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10725-023-01083-0\">https://doi.org/10.1007/s10725-023-01083-0</a>","ama":"Bieleszová K, Hladík P, Kubala M, et al. New fluorescent auxin derivatives: Anti-auxin activity and accumulation patterns in Arabidopsis thaliana. <i>Plant Growth Regulation</i>. 2024;102:589-602. doi:<a href=\"https://doi.org/10.1007/s10725-023-01083-0\">10.1007/s10725-023-01083-0</a>","chicago":"Bieleszová, Kristýna, Pavel Hladík, Martin Kubala, Richard Napier, Federica Brunoni, Zuzana Gelová, Lukas Fiedler, et al. “New Fluorescent Auxin Derivatives: Anti-Auxin Activity and Accumulation Patterns in Arabidopsis Thaliana.” <i>Plant Growth Regulation</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10725-023-01083-0\">https://doi.org/10.1007/s10725-023-01083-0</a>."},"publication_status":"published","article_processing_charge":"Yes (via OA deal)","publisher":"Springer Nature","publication_identifier":{"issn":["0167-6903"],"eissn":["1573-5087"]},"doi":"10.1007/s10725-023-01083-0","file":[{"checksum":"e63271b1d57c1f03c1d993fd62cba59c","date_created":"2024-07-16T08:13:24Z","file_size":2847929,"relation":"main_file","success":1,"access_level":"open_access","content_type":"application/pdf","date_updated":"2024-07-16T08:13:24Z","file_name":"2024_PlantGrowthReg_Bieleszova.pdf","creator":"dernst","file_id":"17252"}],"ddc":["580"],"page":"589-602","intvolume":"       102","date_created":"2023-10-22T22:01:15Z","status":"public","scopus_import":"1","has_accepted_license":"1","publication":"Plant Growth Regulation","language":[{"iso":"eng"}],"file_date_updated":"2024-07-16T08:13:24Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Kristýna","full_name":"Bieleszová, Kristýna","last_name":"Bieleszová"},{"first_name":"Pavel","last_name":"Hladík","full_name":"Hladík, Pavel"},{"first_name":"Martin","full_name":"Kubala, Martin","last_name":"Kubala"},{"full_name":"Napier, Richard","last_name":"Napier","first_name":"Richard"},{"first_name":"Federica","last_name":"Brunoni","full_name":"Brunoni, Federica"},{"first_name":"Zuzana","orcid":"0000-0003-4783-1752","last_name":"Gelová","full_name":"Gelová, Zuzana","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425"},{"id":"7c417475-8972-11ed-ae7b-8b674ca26986","full_name":"Fiedler, Lukas","last_name":"Fiedler","first_name":"Lukas"},{"first_name":"Ivan","last_name":"Kulich","id":"57a1567c-8314-11eb-9063-c9ddc3451a54","full_name":"Kulich, Ivan"},{"last_name":"Strnad","full_name":"Strnad, Miroslav","first_name":"Miroslav"},{"first_name":"Karel","last_name":"Doležal","full_name":"Doležal, Karel"},{"last_name":"Novák","full_name":"Novák, Ondřej","first_name":"Ondřej"},{"first_name":"Jiří","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml"},{"first_name":"Asta","full_name":"Žukauskaitė, Asta","last_name":"Žukauskaitė"}],"acknowledgement":"The authors would like to thank Karolína Kubiasová and Iñigo Saiz-Fernández for valuable scientific discussions. Open access publishing supported by the National Technical Library in Prague. This work was supported by the Palacký University Olomouc Young Researcher Grant Competition (JG_2020_002), by the Internal Grant Agency of Palacký University Olomouc (IGA_PrF_2023_016, IGA_PrF_2023_031), by the Ministry of Education, Youth and Sports of the Czech Republic through the European Regional Development Fund-Project Plants as a tool for sustainable global development (CZ.02.1.01/0.0/0.0/16_019/0000827) and the project Support of mobility at Palacký University Olomouc II. (CZ.02.2.69/0.0/0.0/18_053/0016919). The Biacore T200 SPR instrument was provided by the WISB Research Technology Facility within the School of Life Sciences, University of Warwick.","type":"journal_article","oa":1,"_id":"14447"},{"oa":1,"arxiv":1,"_id":"14451","corr_author":"1","issue":"2","file_date_updated":"2024-07-16T08:08:54Z","author":[{"id":"2CEB641C-A400-11E9-A717-D712E6697425","full_name":"Cornalba, Federico","last_name":"Cornalba","first_name":"Federico","orcid":"0000-0002-6269-5149"},{"first_name":"Constantin","last_name":"Disselkamp","full_name":"Disselkamp, Constantin"},{"last_name":"Scassola","full_name":"Scassola, Davide","first_name":"Davide"},{"last_name":"Helf","full_name":"Helf, Christopher","first_name":"Christopher"}],"acknowledgement":"Open access funding provided by Università degli Studi di Trieste within the CRUI-CARE Agreement. Funding was provided by Austrian Science Fund (Grant No. F65), Horizon 2020 (Grant No. 754411) and Österreichische Forschungsförderungsgesellschaft.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_created":"2023-10-22T22:01:16Z","scopus_import":"1","status":"public","publication":"Neural Computing and Applications","language":[{"iso":"eng"}],"has_accepted_license":"1","ddc":["000"],"file":[{"content_type":"application/pdf","date_updated":"2024-07-16T08:08:54Z","file_name":"2024_NeuralCompApplications_Cornalba.pdf","creator":"dernst","file_id":"17251","checksum":"04573d8e74c6119b97c2ca0a984e19a1","date_created":"2024-07-16T08:08:54Z","relation":"main_file","file_size":4412285,"success":1,"access_level":"open_access"}],"page":"617-637","pmid":1,"intvolume":"        36","year":"2024","date_published":"2024-01-01T00:00:00Z","citation":{"ista":"Cornalba F, Disselkamp C, Scassola D, Helf C. 2024. Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. Neural Computing and Applications. 36(2), 617–637.","mla":"Cornalba, Federico, et al. “Multi-Objective Reward Generalization: Improving Performance of Deep Reinforcement Learning for Applications in Single-Asset Trading.” <i>Neural Computing and Applications</i>, vol. 36, no. 2, Springer Nature, 2024, pp. 617–37, doi:<a href=\"https://doi.org/10.1007/s00521-023-09033-7\">10.1007/s00521-023-09033-7</a>.","ieee":"F. Cornalba, C. Disselkamp, D. Scassola, and C. Helf, “Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading,” <i>Neural Computing and Applications</i>, vol. 36, no. 2. Springer Nature, pp. 617–637, 2024.","apa":"Cornalba, F., Disselkamp, C., Scassola, D., &#38; Helf, C. (2024). Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. <i>Neural Computing and Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00521-023-09033-7\">https://doi.org/10.1007/s00521-023-09033-7</a>","short":"F. Cornalba, C. Disselkamp, D. Scassola, C. Helf, Neural Computing and Applications 36 (2024) 617–637.","chicago":"Cornalba, Federico, Constantin Disselkamp, Davide Scassola, and Christopher Helf. “Multi-Objective Reward Generalization: Improving Performance of Deep Reinforcement Learning for Applications in Single-Asset Trading.” <i>Neural Computing and Applications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00521-023-09033-7\">https://doi.org/10.1007/s00521-023-09033-7</a>.","ama":"Cornalba F, Disselkamp C, Scassola D, Helf C. Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading. <i>Neural Computing and Applications</i>. 2024;36(2):617-637. doi:<a href=\"https://doi.org/10.1007/s00521-023-09033-7\">10.1007/s00521-023-09033-7</a>"},"publication_identifier":{"eissn":["1433-3058"],"issn":["0941-0643"]},"publisher":"Springer Nature","article_processing_charge":"Yes (via OA deal)","doi":"10.1007/s00521-023-09033-7","publication_status":"published","date_updated":"2025-04-23T07:39:14Z","department":[{"_id":"JuFi"}],"month":"01","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"title":"Multi-objective reward generalization: Improving performance of Deep Reinforcement Learning for applications in single-asset trading","ec_funded":1,"oa_version":"Published Version","day":"01","volume":36,"external_id":{"arxiv":["2203.04579"],"pmid":["38187995"]},"quality_controlled":"1","project":[{"grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems"},{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"}],"article_type":"original","abstract":[{"lang":"eng","text":"We investigate the potential of Multi-Objective, Deep Reinforcement Learning for stock and cryptocurrency single-asset trading: in particular, we consider a Multi-Objective algorithm which generalizes the reward functions and discount factor (i.e., these components are not specified a priori, but incorporated in the learning process). Firstly, using several important assets (BTCUSD, ETHUSDT, XRPUSDT, AAPL, SPY, NIFTY50), we verify the reward generalization property of the proposed Multi-Objective algorithm, and provide preliminary statistical evidence showing increased predictive stability over the corresponding Single-Objective strategy. Secondly, we show that the Multi-Objective algorithm has a clear edge over the corresponding Single-Objective strategy when the reward mechanism is sparse (i.e., when non-null feedback is infrequent over time). Finally, we discuss the generalization properties with respect to the discount factor. The entirety of our code is provided in open-source format."}]},{"oa_version":"Published Version","day":"01","volume":33,"external_id":{"pmid":["37843465"],"isi":["001085119000001"]},"quality_controlled":"1","abstract":[{"lang":"eng","text":"Inversions are thought to play a key role in adaptation and speciation, suppressing recombination between diverging populations. Genes influencing adaptive traits cluster in inversions, and changes in inversion frequencies are associated with environmental differences. However, in many organisms, it is unclear if inversions are geographically and taxonomically widespread. The intertidal snail, Littorina saxatilis, is one such example. Strong associations between putative polymorphic inversions and phenotypic differences have been demonstrated between two ecotypes of L. saxatilis in Sweden and inferred elsewhere, but no direct evidence for inversion polymorphism currently exists across the species range. Using whole genome data from 107 snails, most inversion polymorphisms were found to be widespread across the species range. The frequencies of some inversion arrangements were significantly different among ecotypes, suggesting a parallel adaptive role. Many inversions were also polymorphic in the sister species, L. arcana, hinting at an ancient origin."}],"article_type":"original","OA_type":"hybrid","citation":{"ista":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. 2024. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology. 33(24), e17160.","ieee":"J. Reeve, R. K. Butlin, E. L. Koch, S. Stankowski, and R. Faria, “Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana),” <i>Molecular Ecology</i>, vol. 33, no. 24. Wiley, 2024.","mla":"Reeve, James, et al. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” <i>Molecular Ecology</i>, vol. 33, no. 24, e17160, Wiley, 2024, doi:<a href=\"https://doi.org/10.1111/mec.17160\">10.1111/mec.17160</a>.","short":"J. Reeve, R.K. Butlin, E.L. Koch, S. Stankowski, R. Faria, Molecular Ecology 33 (2024).","apa":"Reeve, J., Butlin, R. K., Koch, E. L., Stankowski, S., &#38; Faria, R. (2024). Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.17160\">https://doi.org/10.1111/mec.17160</a>","ama":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). <i>Molecular Ecology</i>. 2024;33(24). doi:<a href=\"https://doi.org/10.1111/mec.17160\">10.1111/mec.17160</a>","chicago":"Reeve, James, Roger K. Butlin, Eva L. Koch, Sean Stankowski, and Rui Faria. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” <i>Molecular Ecology</i>. Wiley, 2024. <a href=\"https://doi.org/10.1111/mec.17160\">https://doi.org/10.1111/mec.17160</a>."},"year":"2024","date_published":"2024-12-01T00:00:00Z","publication_status":"published","doi":"10.1111/mec.17160","publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"article_processing_charge":"Yes (in subscription journal)","publisher":"Wiley","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"NiBa"}],"month":"12","date_updated":"2025-01-09T07:53:18Z","title":"Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana)","isi":1,"article_number":"e17160","status":"public","scopus_import":"1","date_created":"2023-10-29T23:01:17Z","has_accepted_license":"1","language":[{"iso":"eng"}],"publication":"Molecular Ecology","file":[{"file_id":"18785","creator":"dernst","content_type":"application/pdf","file_name":"2024_MolecularEcology_Reeve.pdf","date_updated":"2025-01-09T07:52:12Z","relation":"main_file","file_size":6228700,"success":1,"access_level":"open_access","checksum":"686576036663f489c2d079df3079d126","date_created":"2025-01-09T07:52:12Z"}],"ddc":["570"],"pmid":1,"intvolume":"        33","oa":1,"OA_place":"publisher","_id":"14463","file_date_updated":"2025-01-09T07:52:12Z","issue":"24","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Reeve","full_name":"Reeve, James","first_name":"James"},{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."},{"full_name":"Koch, Eva L.","last_name":"Koch","first_name":"Eva L."},{"full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","last_name":"Stankowski","first_name":"Sean"},{"first_name":"Rui","last_name":"Faria","full_name":"Faria, Rui"}],"acknowledgement":"We would like to thank members of the Littorina team for their advice and feedback during this project. In particular, we thank Alan Le Moan, who inspired us to look at heterozygosity differences to identify inversions, and Katherine Hearn for helping with the PCA scripts. We thank Edinburgh Genomics for library preparation and sequencing. Sample collections, sequencing and data preparation were supported by the European Research Council (ERC-2015-AdG-693030- BARRIERS) and the Natural Environment Research Council (NE/P001610/1). The analysis was supported by the Swedish Research Council (vetenskaprådet; 2018-03695_VR) and the Portuguese Foundation for Science and Technology (Fundación para a Ciência e Tecnologia) through a research project (PTDC/BIA-EVL/1614/2021) and CEEC contract (2020.00275.CEECIND)."},{"intvolume":"       121","pmid":1,"file":[{"creator":"dernst","file_id":"15124","content_type":"application/pdf","file_name":"2024_PNAS_Habig.pdf","date_updated":"2024-03-19T09:02:57Z","relation":"main_file","file_size":5750361,"success":1,"access_level":"open_access","checksum":"f5e871db617b682edc71fcd08670dc81","date_created":"2024-03-19T09:02:57Z"}],"ddc":["570"],"has_accepted_license":"1","publication":"Proceedings of the National Academy of Sciences of the United States of America","language":[{"iso":"eng"}],"scopus_import":"1","date_created":"2023-10-31T13:30:00Z","status":"public","APC_amount":"3040,36 EUR","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Michael","full_name":"Habig, Michael","last_name":"Habig"},{"first_name":"Anna V","last_name":"Grasse","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Müller","full_name":"Müller, Judith","first_name":"Judith"},{"full_name":"Stukenbrock, Eva H.","last_name":"Stukenbrock","first_name":"Eva H."},{"first_name":"Hanna","last_name":"Leitner","full_name":"Leitner, Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"acknowledgement":"We thank Bernhardt Steinwender, Jorgen Eilenberg, and Nicolai V. Meyling for the fungal strains. We further thank Chengshu Wang for providing the short sequencing reads for M. guizhouense ARESF977 he used for his published genome assembly, and Kristian Ullrich for help in the bioinformatics analysis for methylation pattern in Nanopore reads, and the VBC and the Max Planck Society for the use of their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg for discussion, and Tal Dagan and Jens Rolff for comments on a previous version of the manuscript. Fig. 1A was created with BioRender.com. This study received funding by the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German Research Foundation (DFG grant HA9263/1-1) to M.H.","type":"journal_article","file_date_updated":"2024-03-19T09:02:57Z","corr_author":"1","issue":"11","_id":"14478","OA_place":"publisher","oa":1,"OA_type":"hybrid","abstract":[{"lang":"eng","text":"Entire chromosomes are typically only transmitted vertically from one generation to the next. The horizontal transfer of such chromosomes has long been considered improbable, yet gained recent support in several pathogenic fungi where it may affect the fitness or host specificity. To date, it is unknown how these transfers occur, how common they are and whether they can occur between different species. In this study, we show multiple independent instances of horizontal transfers of the same accessory chromosome between two distinct strains of the asexual entomopathogenic fungus<jats:italic>Metarhizium robertsii</jats:italic>during experimental co-infection of its insect host, the Argentine ant. Notably, only the one chromosome – but no other – was transferred from the donor to the recipient strain. The recipient strain, now harboring the accessory chromosome, exhibited a competitive advantage under certain host conditions. By phylogenetic analysis we further demonstrate that the same accessory chromosome was horizontally transferred in a natural environment between<jats:italic>M. robertsii</jats:italic>and another congeneric insect pathogen,<jats:italic>M. guizhouense</jats:italic>. Hence horizontal chromosome transfer is not limited to the observed frequent events within species during experimental infections but also occurs naturally across species. The transferred accessory chromosome contains genes that might be involved in its preferential horizontal transfer, encoding putative histones and histone-modifying enzymes, but also putative virulence factors that may support its establishment. Our study reveals that both intra- and interspecies horizontal transfer of entire chromosomes is more frequent than previously assumed, likely representing a not uncommon mechanism for gene exchange.</jats:p><jats:sec><jats:title>Significance Statement</jats:title><jats:p>The enormous success of bacterial pathogens has been attributed to their ability to exchange genetic material between one another. Similarly, in eukaryotes, horizontal transfer of genetic material allowed the spread of virulence factors across species. The horizontal transfer of whole chromosomes could be an important pathway for such exchange of genetic material, but little is known about the origin of transferable chromosomes and how frequently they are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes that are non-essential but may provide fitness benefits - is common during fungal co-infections and is even possible between distant pathogenic species, highlighting the importance of horizontal gene transfer via chromosome transfer also for the evolution and function of eukaryotic pathogens."}],"article_type":"original","quality_controlled":"1","external_id":{"pmid":["38442176"],"isi":["001207630200005"]},"project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","name":"Epidemics in ant societies on a chip","call_identifier":"H2020","grant_number":"771402"}],"oa_version":"Published Version","volume":121,"day":"12","ec_funded":1,"title":"Frequent horizontal chromosome transfer between asexual fungal insect pathogens","article_number":"e2316284121","isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"date_updated":"2025-08-05T13:30:51Z","month":"03","department":[{"_id":"SyCr"}],"publication_status":"published","article_processing_charge":"Yes (in subscription journal)","publisher":"National Academy of Sciences","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"doi":"10.1073/pnas.2316284121","date_published":"2024-03-12T00:00:00Z","year":"2024","citation":{"ista":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. 2024. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. Proceedings of the National Academy of Sciences of the United States of America. 121(11), e2316284121.","mla":"Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 11, e2316284121, National Academy of Sciences, 2024, doi:<a href=\"https://doi.org/10.1073/pnas.2316284121\">10.1073/pnas.2316284121</a>.","ieee":"M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer, “Frequent horizontal chromosome transfer between asexual fungal insect pathogens,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 11. National Academy of Sciences, 2024.","apa":"Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., &#38; Cremer, S. (2024). Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2316284121\">https://doi.org/10.1073/pnas.2316284121</a>","short":"M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","chicago":"Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2024. <a href=\"https://doi.org/10.1073/pnas.2316284121\">https://doi.org/10.1073/pnas.2316284121</a>.","ama":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2024;121(11). doi:<a href=\"https://doi.org/10.1073/pnas.2316284121\">10.1073/pnas.2316284121</a>"}}]