---
_id: '12082'
abstract:
- lang: eng
text: Proximity-dependent protein labeling provides a powerful in vivo strategy
to characterize the interactomes of specific proteins. We previously optimized
a proximity labeling protocol for Caenorhabditis elegans using the highly active
biotin ligase TurboID. A significant constraint on the sensitivity of TurboID
is the presence of abundant endogenously biotinylated proteins that take up bandwidth
in the mass spectrometer, notably carboxylases that use biotin as a cofactor.
In C. elegans, these comprise POD-2/acetyl-CoA carboxylase alpha, PCCA-1/propionyl-CoA
carboxylase alpha, PYC-1/pyruvate carboxylase, and MCCC-1/methylcrotonyl-CoA carboxylase
alpha. Here, we developed ways to remove these carboxylases prior to streptavidin
purification and mass spectrometry by engineering their corresponding genes to
add a C-terminal His10 tag. This allows us to deplete them from C. elegans lysates
using immobilized metal affinity chromatography. To demonstrate the method's efficacy,
we use it to expand the interactome map of the presynaptic active zone protein
ELKS-1. We identify many known active zone proteins, including UNC-10/RIM, SYD-2/liprin-alpha,
SAD-1/BRSK1, CLA-1/CLArinet, C16E9.2/Sentryn, as well as previously uncharacterized
potentially synaptic proteins such as the ortholog of human angiomotin, F59C12.3
and the uncharacterized protein R148.3. Our approach provides a quick and inexpensive
solution to a common contaminant problem in biotin-dependent proximity labeling.
The approach may be applicable to other model organisms and will enable deeper
and more complete analysis of interactors for proteins of interest.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We thank de Bono laboratory members for helpful comments on the
article and the Mass Spec Facilities at IST Austria and Max Perutz Labs for invaluable
discussions and comments on how to optimize mass spec analyses of worm samples.
We are grateful to Ekaterina Lashmanova for designing the degron knock-in constructs
and preparing the injection mixes for CRISPR/Cas9-mediated genome editing. All LC–MS/MS
analyses were performed on instruments of the Vienna BioCenter Core Facilities instrument
pool.\r\nThis work was supported by a Wellcome Investigator Award (grant no.: 209504/Z/17/Z
) to M.d.B. and an ISTplus Fellowship to M.A. (Marie Sklodowska-Curie agreement
no.: 754411)."
article_number: '102343'
article_processing_charge: No
article_type: original
author:
- first_name: Murat
full_name: Artan, Murat
id: C407B586-6052-11E9-B3AE-7006E6697425
last_name: Artan
orcid: 0000-0001-8945-6992
- first_name: Markus
full_name: Hartl, Markus
last_name: Hartl
- first_name: Weiqiang
full_name: Chen, Weiqiang
last_name: Chen
- first_name: Mario
full_name: De Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: De Bono
orcid: 0000-0001-8347-0443
citation:
ama: Artan M, Hartl M, Chen W, de Bono M. Depletion of endogenously biotinylated
carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in
Caenorhabditis elegans. Journal of Biological Chemistry. 2022;298(9). doi:10.1016/j.jbc.2022.102343
apa: Artan, M., Hartl, M., Chen, W., & de Bono, M. (2022). Depletion of endogenously
biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity
labeling in Caenorhabditis elegans. Journal of Biological Chemistry. Elsevier.
https://doi.org/10.1016/j.jbc.2022.102343
chicago: Artan, Murat, Markus Hartl, Weiqiang Chen, and Mario de Bono. “Depletion
of Endogenously Biotinylated Carboxylases Enhances the Sensitivity of TurboID-Mediated
Proximity Labeling in Caenorhabditis Elegans.” Journal of Biological Chemistry.
Elsevier, 2022. https://doi.org/10.1016/j.jbc.2022.102343.
ieee: M. Artan, M. Hartl, W. Chen, and M. de Bono, “Depletion of endogenously biotinylated
carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in
Caenorhabditis elegans,” Journal of Biological Chemistry, vol. 298, no.
9. Elsevier, 2022.
ista: Artan M, Hartl M, Chen W, de Bono M. 2022. Depletion of endogenously biotinylated
carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in
Caenorhabditis elegans. Journal of Biological Chemistry. 298(9), 102343.
mla: Artan, Murat, et al. “Depletion of Endogenously Biotinylated Carboxylases Enhances
the Sensitivity of TurboID-Mediated Proximity Labeling in Caenorhabditis Elegans.”
Journal of Biological Chemistry, vol. 298, no. 9, 102343, Elsevier, 2022,
doi:10.1016/j.jbc.2022.102343.
short: M. Artan, M. Hartl, W. Chen, M. de Bono, Journal of Biological Chemistry
298 (2022).
corr_author: '1'
date_created: 2022-09-11T22:01:55Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2025-04-14T07:44:00Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1016/j.jbc.2022.102343
ec_funded: 1
external_id:
isi:
- '000884241800011'
pmid:
- '35933017'
file:
- access_level: open_access
checksum: e726c7b9315230e6710e0b1f1d1677e9
content_type: application/pdf
creator: dernst
date_created: 2022-09-12T08:14:50Z
date_updated: 2022-09-12T08:14:50Z
file_id: '12092'
file_name: 2022_JBC_Artan.pdf
file_size: 2101656
relation: main_file
success: 1
file_date_updated: 2022-09-12T08:14:50Z
has_accepted_license: '1'
intvolume: ' 298'
isi: 1
issue: '9'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
grant_number: 209504/A/17/Z
name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Biological Chemistry
publication_identifier:
eissn:
- 1083-351X
issn:
- 0021-9258
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Depletion of endogenously biotinylated carboxylases enhances the sensitivity
of TurboID-mediated proximity labeling in Caenorhabditis elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 298
year: '2022'
...
---
_id: '12083'
abstract:
- lang: eng
text: We consider the many-body time evolution of weakly interacting bosons in the
mean field regime for initial coherent states. We show that bounded k-particle
operators, corresponding to dependent random variables, satisfy both a law of
large numbers and a central limit theorem.
acknowledgement: S.R. would like to thank Robert Seiringer and Benedikt Stufler for
helpful discussions. Funding from the European Union’s Horizon 2020 Research and
Innovation Program under the ERC grant (Grant Agreement No. 694227) and under the
Marie Skłodowska-Curie grant (Agreement No. 754411) is acknowledged.
article_number: '081902'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Simone Anna Elvira
full_name: Rademacher, Simone Anna Elvira
id: 856966FE-A408-11E9-977E-802DE6697425
last_name: Rademacher
orcid: 0000-0001-5059-4466
citation:
ama: Rademacher SAE. Dependent random variables in quantum dynamics. Journal
of Mathematical Physics. 2022;63(8). doi:10.1063/5.0086712
apa: Rademacher, S. A. E. (2022). Dependent random variables in quantum dynamics.
Journal of Mathematical Physics. AIP Publishing. https://doi.org/10.1063/5.0086712
chicago: Rademacher, Simone Anna Elvira. “Dependent Random Variables in Quantum
Dynamics.” Journal of Mathematical Physics. AIP Publishing, 2022. https://doi.org/10.1063/5.0086712.
ieee: S. A. E. Rademacher, “Dependent random variables in quantum dynamics,” Journal
of Mathematical Physics, vol. 63, no. 8. AIP Publishing, 2022.
ista: Rademacher SAE. 2022. Dependent random variables in quantum dynamics. Journal
of Mathematical Physics. 63(8), 081902.
mla: Rademacher, Simone Anna Elvira. “Dependent Random Variables in Quantum Dynamics.”
Journal of Mathematical Physics, vol. 63, no. 8, 081902, AIP Publishing,
2022, doi:10.1063/5.0086712.
short: S.A.E. Rademacher, Journal of Mathematical Physics 63 (2022).
corr_author: '1'
date_created: 2022-09-11T22:01:56Z
date_published: 2022-08-25T00:00:00Z
date_updated: 2025-04-14T07:26:59Z
day: '25'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1063/5.0086712
ec_funded: 1
external_id:
arxiv:
- '2112.04817'
isi:
- '000844402500001'
file:
- access_level: open_access
checksum: e6fb0cf3f0327739c5e69a2cfc4020eb
content_type: application/pdf
creator: dernst
date_created: 2022-09-12T07:35:34Z
date_updated: 2022-09-12T07:35:34Z
file_id: '12089'
file_name: 2022_JourMathPhysics_Rademacher.pdf
file_size: 4552261
relation: main_file
success: 1
file_date_updated: 2022-09-12T07:35:34Z
has_accepted_license: '1'
intvolume: ' 63'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Mathematical Physics
publication_identifier:
issn:
- 0022-2488
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dependent random variables in quantum dynamics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 63
year: '2022'
...
---
_id: '12084'
abstract:
- lang: eng
text: Neuronal networks encode information through patterns of activity that define
the networks’ function. The neurons’ activity relies on specific connectivity
structures, yet the link between structure and function is not fully understood.
Here, we tackle this structure-function problem with a new conceptual approach.
Instead of manipulating the connectivity directly, we focus on upper triangular
matrices, which represent the network dynamics in a given orthonormal basis obtained
by the Schur decomposition. This abstraction allows us to independently manipulate
the eigenspectrum and feedforward structures of a connectivity matrix. Using this
method, we describe a diverse repertoire of non-normal transient amplification,
and to complement the analysis of the dynamical regimes, we quantify the geometry
of output trajectories through the effective rank of both the eigenvector and
the dynamics matrices. Counter-intuitively, we find that shrinking the eigenspectrum’s
imaginary distribution leads to highly amplifying regimes in linear and long-lasting
dynamics in nonlinear networks. We also find a trade-off between amplification
and dimensionality of neuronal dynamics, i.e., trajectories in neuronal state-space.
Networks that can amplify a large number of orthogonal initial conditions produce
neuronal trajectories that lie in the same subspace of the neuronal state-space.
Finally, we examine networks of excitatory and inhibitory neurons. We find that
the strength of global inhibition is directly linked with the amplitude of amplification,
such that weakening inhibitory weights also decreases amplification, and that
the eigenspectrum’s imaginary distribution grows with an increase in the ratio
between excitatory-to-inhibitory and excitatory-to-excitatory connectivity strengths.
Consequently, the strength of global inhibition reveals itself as a strong signature
for amplification and a potential control mechanism to switch dynamical regimes.
Our results shed a light on how biological networks, i.e., networks constrained
by Dale’s law, may be optimised for specific dynamical regimes.
acknowledgement: 'We thank Friedemann Zenke for his comments, especially on the effect
of the self loops on the spectrum. We also thank Ken Miller and Bill Podlaski for
helpful comments. This research was funded by a Wellcome Trust and Royal Society
Henry Dale Research Fellowship (WT100000; TPV), a Wellcome Senior Research Fellowship
(214316/Z/18/Z; GC, EJA, and TPV), and a Research Project Grant by the Leverhulme
Trust (RPG-2016-446; EJA and TPV). '
article_number: e1010365
article_processing_charge: No
article_type: original
author:
- first_name: Georgia
full_name: Christodoulou, Georgia
last_name: Christodoulou
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Everton J.
full_name: Agnes, Everton J.
last_name: Agnes
citation:
ama: Christodoulou G, Vogels TP, Agnes EJ. Regimes and mechanisms of transient amplification
in abstract and biological neural networks. PLoS Computational Biology.
2022;18(8). doi:10.1371/journal.pcbi.1010365
apa: Christodoulou, G., Vogels, T. P., & Agnes, E. J. (2022). Regimes and mechanisms
of transient amplification in abstract and biological neural networks. PLoS
Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1010365
chicago: Christodoulou, Georgia, Tim P Vogels, and Everton J. Agnes. “Regimes and
Mechanisms of Transient Amplification in Abstract and Biological Neural Networks.”
PLoS Computational Biology. Public Library of Science, 2022. https://doi.org/10.1371/journal.pcbi.1010365.
ieee: G. Christodoulou, T. P. Vogels, and E. J. Agnes, “Regimes and mechanisms of
transient amplification in abstract and biological neural networks,” PLoS Computational
Biology, vol. 18, no. 8. Public Library of Science, 2022.
ista: Christodoulou G, Vogels TP, Agnes EJ. 2022. Regimes and mechanisms of transient
amplification in abstract and biological neural networks. PLoS Computational Biology.
18(8), e1010365.
mla: Christodoulou, Georgia, et al. “Regimes and Mechanisms of Transient Amplification
in Abstract and Biological Neural Networks.” PLoS Computational Biology,
vol. 18, no. 8, e1010365, Public Library of Science, 2022, doi:10.1371/journal.pcbi.1010365.
short: G. Christodoulou, T.P. Vogels, E.J. Agnes, PLoS Computational Biology 18
(2022).
corr_author: '1'
date_created: 2022-09-11T22:01:56Z
date_published: 2022-08-15T00:00:00Z
date_updated: 2025-06-11T13:51:21Z
day: '15'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1371/journal.pcbi.1010365
external_id:
isi:
- '000937227700001'
pmid:
- '35969604'
file:
- access_level: open_access
checksum: 8a81ab29f837991ee0ea770817c4a50e
content_type: application/pdf
creator: dernst
date_created: 2022-09-12T07:47:55Z
date_updated: 2022-09-12T07:47:55Z
file_id: '12090'
file_name: 2022_PLoSCompBio_Christodoulou.pdf
file_size: 2867337
relation: main_file
success: 1
file_date_updated: 2022-09-12T07:47:55Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
grant_number: 214316/Z/18/Z
name: "Whatâ\x80\x99s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
neuronal networks."
publication: PLoS Computational Biology
publication_identifier:
eissn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regimes and mechanisms of transient amplification in abstract and biological
neural networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2022'
...
---
_id: '12085'
abstract:
- lang: eng
text: Molecular catch bonds are ubiquitous in biology and essential for processes
like leucocyte extravasion1 and cellular mechanosensing2. Unlike normal (slip)
bonds, catch bonds strengthen under tension. The current paradigm is that this
feature provides ‘strength on demand3’, thus enabling cells to increase rigidity
under stress1,4,5,6. However, catch bonds are often weaker than slip bonds because
they have cryptic binding sites that are usually buried7,8. Here we show that
catch bonds render reconstituted cytoskeletal actin networks stronger than slip
bonds, even though the individual bonds are weaker. Simulations show that slip
bonds remain trapped in stress-free areas, whereas weak binding allows catch bonds
to mitigate crack initiation by moving to high-tension areas. This ‘dissociation
on demand’ explains how cells combine mechanical strength with the adaptability
required for shape change, and is relevant to diseases where catch bonding is
compromised7,9, including focal segmental glomerulosclerosis10 caused by the α-actinin-4
mutant studied here. We surmise that catch bonds are the key to create life-like
materials.
acknowledgement: 'We thank M. van Hecke and C. Alkemade for critical reading of the
manuscript. We thank P. R. ten Wolde, K. Storm, W. Ellenbroek, C. Broedersz, D.
Brueckner and M. Berger for fruitful discussions. We thank W. Brieher and V. Tang
from the University of Illinois for the kind gift of purified α-actinin-4 (WT and
the K255E point mutant) and their plasmids; M. Kuit-Vinkenoog and J. den Haan for
actin and further purification of α-actinin-4; A. Goutou and I. Isturiz-Petitjean
for co-sedimentation measurements and V. Sunderlíková for the design, mutagenesis,
cloning and purifying of the α-actinin-4 constructs used in the single-molecule
experiments. We gratefully acknowledge financial support from the following sources:
research program of the Netherlands Organization for Scientific Research (NWO) (S.J.T.,
A.R. and M.J.A.); ERC Starting Grant (335672-MINICELL) (G.H.K. and Y.M.). ‘BaSyC—Building
a Synthetic Cell’ Gravitation grant (024.003.019) of the Netherlands Ministry of
Education, Culture and Science (OCW) and the Netherlands Organisation for Scientific
Research (G.H.K. and L.B.); and support from the National Institutes of Health (1R01GM126256)
(T.K. and W.J.).'
article_processing_charge: No
article_type: original
author:
- first_name: Yuval
full_name: Mulla, Yuval
last_name: Mulla
- first_name: Mario
full_name: Avellaneda Sarrió, Mario
id: DC4BA84C-56E6-11EA-AD5D-348C3DDC885E
last_name: Avellaneda Sarrió
orcid: 0000-0001-6406-524X
- first_name: Antoine
full_name: Roland, Antoine
last_name: Roland
- first_name: Lucia
full_name: Baldauf, Lucia
last_name: Baldauf
- first_name: Wonyeong
full_name: Jung, Wonyeong
last_name: Jung
- first_name: Taeyoon
full_name: Kim, Taeyoon
last_name: Kim
- first_name: Sander J.
full_name: Tans, Sander J.
last_name: Tans
- first_name: Gijsje H.
full_name: Koenderink, Gijsje H.
last_name: Koenderink
citation:
ama: Mulla Y, Avellaneda Sarrió M, Roland A, et al. Weak catch bonds make strong
networks. Nature Materials. 2022;21(9):1019-1023. doi:10.1038/s41563-022-01288-0
apa: Mulla, Y., Avellaneda Sarrió, M., Roland, A., Baldauf, L., Jung, W., Kim, T.,
… Koenderink, G. H. (2022). Weak catch bonds make strong networks. Nature Materials.
Springer Nature. https://doi.org/10.1038/s41563-022-01288-0
chicago: Mulla, Yuval, Mario Avellaneda Sarrió, Antoine Roland, Lucia Baldauf, Wonyeong
Jung, Taeyoon Kim, Sander J. Tans, and Gijsje H. Koenderink. “Weak Catch Bonds
Make Strong Networks.” Nature Materials. Springer Nature, 2022. https://doi.org/10.1038/s41563-022-01288-0.
ieee: Y. Mulla et al., “Weak catch bonds make strong networks,” Nature
Materials, vol. 21, no. 9. Springer Nature, pp. 1019–1023, 2022.
ista: Mulla Y, Avellaneda Sarrió M, Roland A, Baldauf L, Jung W, Kim T, Tans SJ,
Koenderink GH. 2022. Weak catch bonds make strong networks. Nature Materials.
21(9), 1019–1023.
mla: Mulla, Yuval, et al. “Weak Catch Bonds Make Strong Networks.” Nature Materials,
vol. 21, no. 9, Springer Nature, 2022, pp. 1019–23, doi:10.1038/s41563-022-01288-0.
short: Y. Mulla, M. Avellaneda Sarrió, A. Roland, L. Baldauf, W. Jung, T. Kim, S.J.
Tans, G.H. Koenderink, Nature Materials 21 (2022) 1019–1023.
date_created: 2022-09-11T22:01:57Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2023-08-03T14:08:47Z
day: '01'
department:
- _id: MiSi
doi: 10.1038/s41563-022-01288-0
external_id:
isi:
- '000844592000002'
pmid:
- '36008604'
intvolume: ' 21'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.07.27.219618
month: '09'
oa: 1
oa_version: Preprint
page: 1019-1023
pmid: 1
publication: Nature Materials
publication_identifier:
eissn:
- 1476-4660
issn:
- 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Weak catch bonds make strong networks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 21
year: '2022'
...
---
_id: '12088'
abstract:
- lang: eng
text: We present a quantum-enabled microwave-telecom interface with bidirectional
conversion efficiencies up to 15% and added input noise quanta as low as 0.16.
Moreover, we observe evidence for electro-optic laser cooling and vacuum amplification.
article_number: FW4D.4
article_processing_charge: No
author:
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
- first_name: William J
full_name: Hease, William J
id: 29705398-F248-11E8-B48F-1D18A9856A87
last_name: Hease
orcid: 0000-0001-9868-2166
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Georg M
full_name: Arnold, Georg M
id: 3770C838-F248-11E8-B48F-1D18A9856A87
last_name: Arnold
orcid: 0000-0003-1397-7876
- first_name: Liu
full_name: Qiu, Liu
id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
last_name: Qiu
orcid: 0000-0003-4345-4267
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: 'Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. Realizing a
quantum-enabled interconnect between microwave and telecom light. In: Conference
on Lasers and Electro-Optics. Optica Publishing Group; 2022. doi:10.1364/CLEO_QELS.2022.FW4D.4'
apa: 'Sahu, R., Hease, W. J., Rueda Sanchez, A. R., Arnold, G. M., Qiu, L., &
Fink, J. M. (2022). Realizing a quantum-enabled interconnect between microwave
and telecom light. In Conference on Lasers and Electro-Optics. San Jose,
CA, United States: Optica Publishing Group. https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4'
chicago: Sahu, Rishabh, William J Hease, Alfredo R Rueda Sanchez, Georg M Arnold,
Liu Qiu, and Johannes M Fink. “Realizing a Quantum-Enabled Interconnect between
Microwave and Telecom Light.” In Conference on Lasers and Electro-Optics.
Optica Publishing Group, 2022. https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4.
ieee: R. Sahu, W. J. Hease, A. R. Rueda Sanchez, G. M. Arnold, L. Qiu, and J. M.
Fink, “Realizing a quantum-enabled interconnect between microwave and telecom
light,” in Conference on Lasers and Electro-Optics, San Jose, CA, United
States, 2022.
ista: 'Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. 2022. Realizing
a quantum-enabled interconnect between microwave and telecom light. Conference
on Lasers and Electro-Optics. CLEO: QELS Fundamental Science, FW4D.4.'
mla: Sahu, Rishabh, et al. “Realizing a Quantum-Enabled Interconnect between Microwave
and Telecom Light.” Conference on Lasers and Electro-Optics, FW4D.4, Optica
Publishing Group, 2022, doi:10.1364/CLEO_QELS.2022.FW4D.4.
short: R. Sahu, W.J. Hease, A.R. Rueda Sanchez, G.M. Arnold, L. Qiu, J.M. Fink,
in:, Conference on Lasers and Electro-Optics, Optica Publishing Group, 2022.
conference:
end_date: 2022-05-20
location: San Jose, CA, United States
name: 'CLEO: QELS Fundamental Science'
start_date: 2022-05-15
corr_author: '1'
date_created: 2022-09-11T22:01:58Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2024-10-09T21:03:27Z
day: '01'
department:
- _id: JoFi
doi: 10.1364/CLEO_QELS.2022.FW4D.4
language:
- iso: eng
month: '05'
oa_version: None
publication: Conference on Lasers and Electro-Optics
publication_identifier:
isbn:
- '9781557528209'
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Realizing a quantum-enabled interconnect between microwave and telecom light
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '12102'
abstract:
- lang: eng
text: 'Given a Markov chain M = (V, v_0, δ), with state space V and a starting state
v_0, and a probability threshold ε, an ε-core is a subset C of states that is
left with probability at most ε. More formally, C ⊆ V is an ε-core, iff ℙ[reach
(V\C)] ≤ ε. Cores have been applied in a wide variety of verification problems
over Markov chains, Markov decision processes, and probabilistic programs, as
a means of discarding uninteresting and low-probability parts of a probabilistic
system and instead being able to focus on the states that are likely to be encountered
in a real-world run. In this work, we focus on the problem of computing a minimal
ε-core in a Markov chain. Our contributions include both negative and positive
results: (i) We show that the decision problem on the existence of an ε-core of
a given size is NP-complete. This solves an open problem posed in [Jan Kretínský
and Tobias Meggendorfer, 2020]. We additionally show that the problem remains
NP-complete even when limited to acyclic Markov chains with bounded maximal vertex
degree; (ii) We provide a polynomial time algorithm for computing a minimal ε-core
on Markov chains over control-flow graphs of structured programs. A straightforward
combination of our algorithm with standard branch prediction techniques allows
one to apply the idea of cores to find a subset of program lines that are left
with low probability and then focus any desired static analysis on this core subset.'
acknowledgement: "The research was partially supported by the Hong Kong Research Grants
Council ECS\r\nProject No. 26208122, ERC CoG 863818 (FoRM-SMArt), the European Union’s
Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
Grant Agreement No. 665385, HKUST– Kaisa Joint Research Institute Project Grant
HKJRI3A-055 and HKUST Startup Grant R9272. Ali Ahmadi and Roodabeh Safavi were interns
at HKUST."
article_number: '29'
article_processing_charge: No
author:
- first_name: Ali
full_name: Ahmadi, Ali
last_name: Ahmadi
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Amir Kafshdar
full_name: Goharshady, Amir Kafshdar
id: 391365CE-F248-11E8-B48F-1D18A9856A87
last_name: Goharshady
orcid: 0000-0003-1702-6584
- first_name: Tobias
full_name: Meggendorfer, Tobias
id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
last_name: Meggendorfer
orcid: 0000-0002-1712-2165
- first_name: Roodabeh
full_name: Safavi Hemami, Roodabeh
id: 72ed2640-8972-11ed-ae7b-f9c81ec75154
last_name: Safavi Hemami
- first_name: Dorde
full_name: Zikelic, Dorde
id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
last_name: Zikelic
orcid: 0000-0002-4681-1699
citation:
ama: 'Ahmadi A, Chatterjee K, Goharshady AK, Meggendorfer T, Safavi Hemami R, Zikelic
D. Algorithms and hardness results for computing cores of Markov chains. In: 42nd
IARCS Annual Conference on Foundations of Software Technology and Theoretical
Computer Science. Vol 250. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
2022. doi:10.4230/LIPIcs.FSTTCS.2022.29'
apa: 'Ahmadi, A., Chatterjee, K., Goharshady, A. K., Meggendorfer, T., Safavi Hemami,
R., & Zikelic, D. (2022). Algorithms and hardness results for computing cores
of Markov chains. In 42nd IARCS Annual Conference on Foundations of Software
Technology and Theoretical Computer Science (Vol. 250). Madras, India: Schloss
Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29'
chicago: Ahmadi, Ali, Krishnendu Chatterjee, Amir Kafshdar Goharshady, Tobias Meggendorfer,
Roodabeh Safavi Hemami, and Dorde Zikelic. “Algorithms and Hardness Results for
Computing Cores of Markov Chains.” In 42nd IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science, Vol. 250. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2022. https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29.
ieee: A. Ahmadi, K. Chatterjee, A. K. Goharshady, T. Meggendorfer, R. Safavi Hemami,
and D. Zikelic, “Algorithms and hardness results for computing cores of Markov
chains,” in 42nd IARCS Annual Conference on Foundations of Software Technology
and Theoretical Computer Science, Madras, India, 2022, vol. 250.
ista: 'Ahmadi A, Chatterjee K, Goharshady AK, Meggendorfer T, Safavi Hemami R, Zikelic
D. 2022. Algorithms and hardness results for computing cores of Markov chains.
42nd IARCS Annual Conference on Foundations of Software Technology and Theoretical
Computer Science. FSTTCS: Foundations of Software Technology and Theoretical Computer
Science vol. 250, 29.'
mla: Ahmadi, Ali, et al. “Algorithms and Hardness Results for Computing Cores of
Markov Chains.” 42nd IARCS Annual Conference on Foundations of Software Technology
and Theoretical Computer Science, vol. 250, 29, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2022, doi:10.4230/LIPIcs.FSTTCS.2022.29.
short: A. Ahmadi, K. Chatterjee, A.K. Goharshady, T. Meggendorfer, R. Safavi Hemami,
D. Zikelic, in:, 42nd IARCS Annual Conference on Foundations of Software Technology
and Theoretical Computer Science, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2022.
conference:
end_date: 2022-12-20
location: Madras, India
name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
start_date: 2022-12-18
corr_author: '1'
date_created: 2023-01-01T23:00:50Z
date_published: 2022-12-14T00:00:00Z
date_updated: 2025-07-10T11:50:23Z
day: '14'
ddc:
- '000'
department:
- _id: KrCh
- _id: GradSch
doi: 10.4230/LIPIcs.FSTTCS.2022.29
ec_funded: 1
file:
- access_level: open_access
checksum: 6660c802489013f034c9e8bd57f4d46e
content_type: application/pdf
creator: dernst
date_created: 2023-01-20T10:39:44Z
date_updated: 2023-01-20T10:39:44Z
file_id: '12324'
file_name: 2022_LIPICs_Ahmadi.pdf
file_size: 872534
relation: main_file
success: 1
file_date_updated: 2023-01-20T10:39:44Z
has_accepted_license: '1'
intvolume: ' 250'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: 42nd IARCS Annual Conference on Foundations of Software Technology and
Theoretical Computer Science
publication_identifier:
isbn:
- '9783959772617'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithms and hardness results for computing cores of Markov chains
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 250
year: '2022'
...
---
_id: '12107'
abstract:
- lang: eng
text: The sensitivity of coarse-grained daily extreme precipitation to sea surface
temperature is analyzed using satellite precipitation estimates over the 300–302.5
K range. A theoretical scaling is proposed, linking changes in coarse-grained
precipitation to changes in fine-scale hourly precipitation area fraction and
changes in conditional fine-scale precipitation rates. The analysis reveals that
the extreme coarse-grained precipitation scaling with temperature (∼7%/K) is dominated
by the fine-scale precipitating fraction scaling (∼6.5%/K) when using a 3 mm/h
fine-scale threshold to delineate the precipitating fraction. These results are
shown to be robust to the selection of the precipitation product and to the percentile
used to characterize the extreme. This new coarse-grained scaling is further related
to the well-known scaling for fine-scale precipitation extremes, and suggests
a compensation between thermodynamic and dynamic contributions or that both contributions
are small with respect to that of fractional coverage. These results suggest that
processes responsible for the changes in fractional coverage are to be accounted
for to assess the sensitivity of coarse-grained extreme daily precipitation to
surface temperature.
acknowledgement: "We thank S. Cloché for her support with the handling of these various
data sets. This study benefited from the IPSL mesocenter ESPRI facility which is
supported by CNRS, UPMC, Labex L-IPSL, CNES and Ecole Polytechnique. We thank Rômulo
A. Jucá Oliveira and Thomas\r\nFiolleau for helpful discussions on satellite data
and precipitation. The authors acknowledge the CNES and CNRS support under the Megha-Tropiques
program. C.M. gratefully acknowledges\r\nfunding from the European Research Council
(ERC) under the European Union's Horizon 2020 research and innovation programme
(Project CLUSTER, Grant agreement 805041). We further\r\nthank the reviewers for
their insightful comments that improved the paper."
article_number: e2022GL100624
article_processing_charge: No
article_type: letter_note
author:
- first_name: Rémy
full_name: Roca, Rémy
last_name: Roca
- first_name: Victorien
full_name: De Meyer, Victorien
last_name: De Meyer
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
citation:
ama: Roca R, De Meyer V, Muller CJ. Precipitating fraction, not intensity, explains
extreme coarse-grained precipitation Clausius-Clapeyron scaling with sea surface
temperature over tropical oceans. Geophysical Research Letters. 2022;49(24).
doi:10.1029/2022GL100624
apa: Roca, R., De Meyer, V., & Muller, C. J. (2022). Precipitating fraction,
not intensity, explains extreme coarse-grained precipitation Clausius-Clapeyron
scaling with sea surface temperature over tropical oceans. Geophysical Research
Letters. Wiley. https://doi.org/10.1029/2022GL100624
chicago: Roca, Rémy, Victorien De Meyer, and Caroline J Muller. “Precipitating Fraction,
Not Intensity, Explains Extreme Coarse-Grained Precipitation Clausius-Clapeyron
Scaling with Sea Surface Temperature over Tropical Oceans.” Geophysical Research
Letters. Wiley, 2022. https://doi.org/10.1029/2022GL100624.
ieee: R. Roca, V. De Meyer, and C. J. Muller, “Precipitating fraction, not intensity,
explains extreme coarse-grained precipitation Clausius-Clapeyron scaling with
sea surface temperature over tropical oceans,” Geophysical Research Letters,
vol. 49, no. 24. Wiley, 2022.
ista: Roca R, De Meyer V, Muller CJ. 2022. Precipitating fraction, not intensity,
explains extreme coarse-grained precipitation Clausius-Clapeyron scaling with
sea surface temperature over tropical oceans. Geophysical Research Letters. 49(24),
e2022GL100624.
mla: Roca, Rémy, et al. “Precipitating Fraction, Not Intensity, Explains Extreme
Coarse-Grained Precipitation Clausius-Clapeyron Scaling with Sea Surface Temperature
over Tropical Oceans.” Geophysical Research Letters, vol. 49, no. 24, e2022GL100624,
Wiley, 2022, doi:10.1029/2022GL100624.
short: R. Roca, V. De Meyer, C.J. Muller, Geophysical Research Letters 49 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-28T00:00:00Z
date_updated: 2023-08-03T14:10:27Z
day: '28'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2022GL100624
external_id:
isi:
- '000924587900001'
file:
- access_level: open_access
checksum: 2c6325cea8938adeea7e3a6f5c2ab64e
content_type: application/pdf
creator: dernst
date_created: 2023-01-20T10:52:31Z
date_updated: 2023-01-20T10:52:31Z
file_id: '12326'
file_name: 2022_GeophysicalResearchLetters_Roca.pdf
file_size: 875379
relation: main_file
success: 1
file_date_updated: 2023-01-20T10:52:31Z
has_accepted_license: '1'
intvolume: ' 49'
isi: 1
issue: '24'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
publication: Geophysical Research Letters
publication_identifier:
eissn:
- 1944-8007
issn:
- 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Precipitating fraction, not intensity, explains extreme coarse-grained precipitation
Clausius-Clapeyron scaling with sea surface temperature over tropical oceans
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 49
year: '2022'
...
---
_id: '12108'
abstract:
- lang: eng
text: The sequential exchange of filament composition to increase filament curvature
was proposed as a mechanism for how some biological polymers deform and cut membranes.
The relationship between the filament composition and its mechanical effect is
lacking. We develop a kinetic model for the assembly of composite filaments that
includes protein–membrane adhesion, filament mechanics and membrane mechanics.
We identify the physical conditions for such a membrane remodeling and show this
mechanism of sequential polymer assembly lowers the energetic barrier for membrane
deformation.
acknowledgement: "We thank T. C. T. Michaels and J. Palacci for useful discussions.
We thank Claudia Flandoli for the illustrations in Fig. 1(b) and Fig. 2. We acknowledge
funding by the European Union’s Horizon 2020 Research and Innovation Programme under
the Marie Skłodowska-Curie Grant\r\nAgreement No. 101034413 (I. P.), the Royal Society
Grant No. UF160266 (A. Š.), the European Research Council under the European Union’s
Horizon 2020 Research and Innovation Programme (Grant No. 802960; B. M., I. P.,
and A. Š.), and the Volkswagen Foundation\r\nLife Grant (B. B. and A. Š). "
article_number: '268101'
article_processing_charge: No
article_type: original
author:
- first_name: Billie
full_name: Meadowcroft, Billie
id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
last_name: Meadowcroft
orcid: 0000-0003-3441-1337
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Anna Katharina
full_name: Pfitzner, Anna Katharina
last_name: Pfitzner
- first_name: Aurélien
full_name: Roux, Aurélien
last_name: Roux
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical
rules for shape-shifting filaments that remodel membranes. Physical Review
Letters. 2022;129(26). doi:10.1103/PhysRevLett.129.268101
apa: Meadowcroft, B., Palaia, I., Pfitzner, A. K., Roux, A., Baum, B., & Šarić,
A. (2022). Mechanochemical rules for shape-shifting filaments that remodel membranes.
Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.129.268101
chicago: Meadowcroft, Billie, Ivan Palaia, Anna Katharina Pfitzner, Aurélien Roux,
Buzz Baum, and Anđela Šarić. “Mechanochemical Rules for Shape-Shifting Filaments
That Remodel Membranes.” Physical Review Letters. American Physical Society,
2022. https://doi.org/10.1103/PhysRevLett.129.268101.
ieee: B. Meadowcroft, I. Palaia, A. K. Pfitzner, A. Roux, B. Baum, and A. Šarić,
“Mechanochemical rules for shape-shifting filaments that remodel membranes,” Physical
Review Letters, vol. 129, no. 26. American Physical Society, 2022.
ista: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. 2022. Mechanochemical
rules for shape-shifting filaments that remodel membranes. Physical Review Letters.
129(26), 268101.
mla: Meadowcroft, Billie, et al. “Mechanochemical Rules for Shape-Shifting Filaments
That Remodel Membranes.” Physical Review Letters, vol. 129, no. 26, 268101,
American Physical Society, 2022, doi:10.1103/PhysRevLett.129.268101.
short: B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical
Review Letters 129 (2022).
corr_author: '1'
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-23T00:00:00Z
date_updated: 2025-04-14T07:54:53Z
day: '23'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.129.268101
ec_funded: 1
external_id:
isi:
- '000906721500001'
pmid:
- '36608212'
intvolume: ' 129'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://doi.org/10.1101/2022.05.10.490642 '
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: eba0f67c-77a9-11ec-83b8-cc8501b3e222
grant_number: '96752'
name: 'The evolution of trafficking: from archaea to eukaryotes'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical rules for shape-shifting filaments that remodel membranes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 129
year: '2022'
...
---
_id: '12110'
abstract:
- lang: eng
text: A recently proposed approach for avoiding the ultraviolet divergence of Hamiltonians
with particle creation is based on interior-boundary conditions (IBCs). The approach
works well in the non-relativistic case, i.e., for the Laplacian operator. Here,
we study how the approach can be applied to Dirac operators. While this has successfully
been done already in one space dimension, and more generally for codimension-1
boundaries, the situation of point sources in three dimensions corresponds to
a codimension-3 boundary. One would expect that, for such a boundary, Dirac operators
do not allow for boundary conditions because they are known not to allow for point
interactions in 3D, which also correspond to a boundary condition. Indeed, we
confirm this expectation here by proving that there is no self-adjoint operator
on a (truncated) Fock space that would correspond to a Dirac operator with an
IBC at configurations with a particle at the origin. However, we also present
a positive result showing that there are self-adjoint operators with an IBC (on
the boundary consisting of configurations with a particle at the origin) that
are away from those configurations, given by a Dirac operator plus a sufficiently
strong Coulomb potential.
acknowledgement: "J.H. gratefully acknowledges the partial financial support by the
ERC Advanced Grant “RMTBeyond” under Grant No. 101020331.\r\n"
article_number: '122302'
article_processing_charge: No
article_type: original
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Roderich
full_name: Tumulka, Roderich
last_name: Tumulka
citation:
ama: Henheik SJ, Tumulka R. Interior-boundary conditions for the Dirac equation
at point sources in three dimensions. Journal of Mathematical Physics.
2022;63(12). doi:10.1063/5.0104675
apa: Henheik, S. J., & Tumulka, R. (2022). Interior-boundary conditions for
the Dirac equation at point sources in three dimensions. Journal of Mathematical
Physics. AIP Publishing. https://doi.org/10.1063/5.0104675
chicago: Henheik, Sven Joscha, and Roderich Tumulka. “Interior-Boundary Conditions
for the Dirac Equation at Point Sources in Three Dimensions.” Journal of Mathematical
Physics. AIP Publishing, 2022. https://doi.org/10.1063/5.0104675.
ieee: S. J. Henheik and R. Tumulka, “Interior-boundary conditions for the Dirac
equation at point sources in three dimensions,” Journal of Mathematical Physics,
vol. 63, no. 12. AIP Publishing, 2022.
ista: Henheik SJ, Tumulka R. 2022. Interior-boundary conditions for the Dirac equation
at point sources in three dimensions. Journal of Mathematical Physics. 63(12),
122302.
mla: Henheik, Sven Joscha, and Roderich Tumulka. “Interior-Boundary Conditions for
the Dirac Equation at Point Sources in Three Dimensions.” Journal of Mathematical
Physics, vol. 63, no. 12, 122302, AIP Publishing, 2022, doi:10.1063/5.0104675.
short: S.J. Henheik, R. Tumulka, Journal of Mathematical Physics 63 (2022).
corr_author: '1'
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2025-04-14T07:57:18Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1063/5.0104675
ec_funded: 1
external_id:
isi:
- '000900748900002'
file:
- access_level: open_access
checksum: 5150287295e0ce4f12462c990744d65d
content_type: application/pdf
creator: dernst
date_created: 2023-01-20T11:58:59Z
date_updated: 2023-01-20T11:58:59Z
file_id: '12327'
file_name: 2022_JourMathPhysics_Henheik.pdf
file_size: 5436804
relation: main_file
success: 1
file_date_updated: 2023-01-20T11:58:59Z
has_accepted_license: '1'
intvolume: ' 63'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Journal of Mathematical Physics
publication_identifier:
issn:
- 0022-2488
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interior-boundary conditions for the Dirac equation at point sources in three
dimensions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 63
year: '2022'
...
---
_id: '12111'
abstract:
- lang: eng
text: Quantum impurities exhibit fascinating many-body phenomena when the small
interacting impurity changes the physics of a large noninteracting environment.
The characterisation of such strongly correlated nonperturbative effects is particularly
challenging due to the infinite size of the environment, and the inability of
local correlators to capture the buildup of long-ranged entanglement in the system.
Here, we harness an entanglement-based observable—the purity of the impurity—as
a witness for the formation of strong correlations. We showcase the utility of
our scheme by exactly solving the open Kondo box model in the small box limit,
and thus describe all-electronic dot-cavity devices. Specifically, we conclusively
characterize the metal-to-insulator phase transition in the system and identify
how the (conducting) dot-lead Kondo singlet is quenched by an (insulating) intraimpurity
singlet formation. Furthermore, we propose an experimentally feasible tomography
protocol for the measurement of the purity, which motivates the observation of
impurity physics through their entanglement build up.
acknowledgement: We thank G. Blatter, T. Ihn, K. Ensslin, M. Goldstein, C. Carisch,
and J. del Pino for illuminating discussions and acknowledge financial support from
the Swiss National Science Foundation (SNSF) through Project No. 190078, and from
the Deutsche Forschungsgemeinschaft (DFG) - Project No. 449653034. Our numerical
implementations are based on the ITensors JULIA library [64].
article_number: '043177'
article_processing_charge: No
article_type: original
author:
- first_name: Lidia
full_name: Stocker, Lidia
last_name: Stocker
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
- first_name: Michael S.
full_name: Ferguson, Michael S.
last_name: Ferguson
- first_name: Oded
full_name: Zilberberg, Oded
last_name: Zilberberg
citation:
ama: Stocker L, Sack S, Ferguson MS, Zilberberg O. Entanglement-based observables
for quantum impurities. Physical Review Research. 2022;4(4). doi:10.1103/PhysRevResearch.4.043177
apa: Stocker, L., Sack, S., Ferguson, M. S., & Zilberberg, O. (2022). Entanglement-based
observables for quantum impurities. Physical Review Research. American
Physical Society. https://doi.org/10.1103/PhysRevResearch.4.043177
chicago: Stocker, Lidia, Stefan Sack, Michael S. Ferguson, and Oded Zilberberg.
“Entanglement-Based Observables for Quantum Impurities.” Physical Review Research.
American Physical Society, 2022. https://doi.org/10.1103/PhysRevResearch.4.043177.
ieee: L. Stocker, S. Sack, M. S. Ferguson, and O. Zilberberg, “Entanglement-based
observables for quantum impurities,” Physical Review Research, vol. 4,
no. 4. American Physical Society, 2022.
ista: Stocker L, Sack S, Ferguson MS, Zilberberg O. 2022. Entanglement-based observables
for quantum impurities. Physical Review Research. 4(4), 043177.
mla: Stocker, Lidia, et al. “Entanglement-Based Observables for Quantum Impurities.”
Physical Review Research, vol. 4, no. 4, 043177, American Physical Society,
2022, doi:10.1103/PhysRevResearch.4.043177.
short: L. Stocker, S. Sack, M.S. Ferguson, O. Zilberberg, Physical Review Research
4 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-02-13T09:08:28Z
day: '01'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/PhysRevResearch.4.043177
file:
- access_level: open_access
checksum: 556820cf6e4af77c8476e5b8f4114d1a
content_type: application/pdf
creator: dernst
date_created: 2023-01-20T12:03:31Z
date_updated: 2023-01-20T12:03:31Z
file_id: '12328'
file_name: 2022_PhysicalReviewResearch_Stocker.pdf
file_size: 2941167
relation: main_file
success: 1
file_date_updated: 2023-01-20T12:03:31Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Entanglement-based observables for quantum impurities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '12116'
abstract:
- lang: eng
text: Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure,
including universities, research centers, and other academic infrastructure (1).
Many Ukrainian scholars and researchers remain in Ukraine, and their work has
suffered from major setbacks (2–4). We call on international scientists and institutions
to support them.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Karishma
full_name: Chhugani, Karishma
last_name: Chhugani
- first_name: Alina
full_name: Frolova, Alina
last_name: Frolova
- first_name: Yuriy
full_name: Salyha, Yuriy
last_name: Salyha
- first_name: Andrada
full_name: Fiscutean, Andrada
last_name: Fiscutean
- first_name: Oksana
full_name: Zlenko, Oksana
last_name: Zlenko
- first_name: Sanita
full_name: Reinsone, Sanita
last_name: Reinsone
- first_name: Walter W.
full_name: Wolfsberger, Walter W.
last_name: Wolfsberger
- first_name: Oleksandra V.
full_name: Ivashchenko, Oleksandra V.
last_name: Ivashchenko
- first_name: Megi
full_name: Maci, Megi
last_name: Maci
- first_name: Dmytro
full_name: Dziuba, Dmytro
last_name: Dziuba
- first_name: Andrii
full_name: Parkhomenko, Andrii
last_name: Parkhomenko
- first_name: Eric
full_name: Bortz, Eric
last_name: Bortz
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Paweł P.
full_name: Łabaj, Paweł P.
last_name: Łabaj
- first_name: Veronika
full_name: Romero, Veronika
last_name: Romero
- first_name: Jakub
full_name: Hlávka, Jakub
last_name: Hlávka
- first_name: Taras K.
full_name: Oleksyk, Taras K.
last_name: Oleksyk
- first_name: Serghei
full_name: Mangul, Serghei
last_name: Mangul
citation:
ama: Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in
Ukraine. Science. 2022;378(6626):1285-1286. doi:10.1126/science.adg0797
apa: Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone,
S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.adg0797
chicago: Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana
Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for
Scholars in Ukraine.” Science. American Association for the Advancement
of Science, 2022. https://doi.org/10.1126/science.adg0797.
ieee: K. Chhugani et al., “Remote opportunities for scholars in Ukraine,”
Science, vol. 378, no. 6626. American Association for the Advancement of
Science, pp. 1285–1286, 2022.
ista: Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger
WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj
PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars
in Ukraine. Science. 378(6626), 1285–1286.
mla: Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.”
Science, vol. 378, no. 6626, American Association for the Advancement of
Science, 2022, pp. 1285–86, doi:10.1126/science.adg0797.
short: K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone,
W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz,
F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science
378 (2022) 1285–1286.
date_created: 2023-01-12T11:56:30Z
date_published: 2022-12-22T00:00:00Z
date_updated: 2025-06-11T13:39:17Z
day: '22'
department:
- _id: FyKo
doi: 10.1126/science.adg0797
external_id:
isi:
- '000963463700023'
pmid:
- '36548425'
intvolume: ' 378'
isi: 1
issue: '6626'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1126/science.adg0797
month: '12'
oa: 1
oa_version: Published Version
page: 1285-1286
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Remote opportunities for scholars in Ukraine
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 378
year: '2022'
...
---
_id: '12117'
abstract:
- lang: eng
text: "To understand how potential gene manipulations affect in vitro microglia,
we provide a set of short protocols to evaluate microglia identity and function.
We detail steps for immunostaining to determine microglia identity. We describe
three functional assays for microglia: phagocytosis, calcium response following
ATP stimulation, and cytokine expression upon inflammatory stimuli. We apply these
protocols to human induced-pluripotent-stem-cell (hiPSC)-derived microglia, but
they can be also applied to other in vitro microglial models including primary
mouse microglia.\r\nFor complete details on the use and execution of this protocol,
please refer to Bartalska et al. (2022).1"
acknowledged_ssus:
- _id: Bio
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation program (grant
No. 715571 to S.S.) and from the Gesellschaft für Forschungsförderung Niederösterreich
(grant No. Sc19-017 to V.H.). We thank Rouven Schulz and Alessandro Venturino for
their insights into functional assays and data analysis, Verena Seiboth for insights
into necessary institutional permission, and ISTA imaging & optics facility (IOF)
especially Bernhard Hochreiter for their support.
article_number: '101866'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Verena
full_name: Hübschmann, Verena
id: 32B7C918-F248-11E8-B48F-1D18A9856A87
last_name: Hübschmann
- first_name: Medina
full_name: Korkut, Medina
id: 4B51CE74-F248-11E8-B48F-1D18A9856A87
last_name: Korkut
orcid: 0000-0003-4309-2251
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: Hübschmann V, Korkut M, Siegert S. Assessing human iPSC-derived microglia identity
and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay. STAR Protocols. 2022;3(4). doi:10.1016/j.xpro.2022.101866
apa: Hübschmann, V., Korkut, M., & Siegert, S. (2022). Assessing human iPSC-derived
microglia identity and function by immunostaining, phagocytosis, calcium activity,
and inflammation assay. STAR Protocols. Elsevier. https://doi.org/10.1016/j.xpro.2022.101866
chicago: Hübschmann, Verena, Medina Korkut, and Sandra Siegert. “Assessing Human
IPSC-Derived Microglia Identity and Function by Immunostaining, Phagocytosis,
Calcium Activity, and Inflammation Assay.” STAR Protocols. Elsevier, 2022.
https://doi.org/10.1016/j.xpro.2022.101866.
ieee: V. Hübschmann, M. Korkut, and S. Siegert, “Assessing human iPSC-derived microglia
identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay,” STAR Protocols, vol. 3, no. 4. Elsevier, 2022.
ista: Hübschmann V, Korkut M, Siegert S. 2022. Assessing human iPSC-derived microglia
identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay. STAR Protocols. 3(4), 101866.
mla: Hübschmann, Verena, et al. “Assessing Human IPSC-Derived Microglia Identity
and Function by Immunostaining, Phagocytosis, Calcium Activity, and Inflammation
Assay.” STAR Protocols, vol. 3, no. 4, 101866, Elsevier, 2022, doi:10.1016/j.xpro.2022.101866.
short: V. Hübschmann, M. Korkut, S. Siegert, STAR Protocols 3 (2022).
corr_author: '1'
date_created: 2023-01-12T11:56:38Z
date_published: 2022-12-16T00:00:00Z
date_updated: 2025-06-11T13:58:47Z
day: '16'
ddc:
- '570'
department:
- _id: SaSi
- _id: GradSch
doi: 10.1016/j.xpro.2022.101866
ec_funded: 1
external_id:
pmid:
- '36595902'
file:
- access_level: open_access
checksum: 3c71b8a60633d42c2f77c49025d5559b
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T09:50:51Z
date_updated: 2023-01-23T09:50:51Z
file_id: '12340'
file_name: 2022_STARProtocols_Huebschmann.pdf
file_size: 6251945
relation: main_file
success: 1
file_date_updated: 2023-01-23T09:50:51Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '4'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Neuroscience
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715571'
name: Microglia action towards neuronal circuit formation and function in health
and disease
- _id: 9B99D380-BA93-11EA-9121-9846C619BF3A
grant_number: SC19-017
name: How human microglia shape developing neurons during health and inflammation
publication: STAR Protocols
publication_identifier:
issn:
- 2666-1667
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '11478'
relation: other
status: public
scopus_import: '1'
status: public
title: Assessing human iPSC-derived microglia identity and function by immunostaining,
phagocytosis, calcium activity, and inflammation assay
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
_id: '12119'
abstract:
- lang: eng
text: Intravascular neutrophils and platelets collaborate in maintaining host integrity,
but their interaction can also trigger thrombotic complications. We report here
that cooperation between neutrophil and platelet lineages extends to the earliest
stages of platelet formation by megakaryocytes in the bone marrow. Using intravital
microscopy, we show that neutrophils “plucked” intravascular megakaryocyte extensions,
termed proplatelets, to control platelet production. Following CXCR4-CXCL12-dependent
migration towards perisinusoidal megakaryocytes, plucking neutrophils actively
pulled on proplatelets and triggered myosin light chain and extracellular-signal-regulated
kinase activation through reactive oxygen species. By these mechanisms, neutrophils
accelerate proplatelet growth and facilitate continuous release of platelets in
steady state. Following myocardial infarction, plucking neutrophils drove excessive
release of young, reticulated platelets and boosted the risk of recurrent ischemia.
Ablation of neutrophil plucking normalized thrombopoiesis and reduced recurrent
thrombosis after myocardial infarction and thrombus burden in venous thrombosis.
We establish neutrophil plucking as a target to reduce thromboischemic events.
acknowledgement: "We thank Coung Kieu and Dominik van den Heuvel for excellent technical
assistance. This work was supported by the German Research Foundation (PE2704/2-1,
PE2704/3-1 to T.P., SFB 1123-project B06 to S.M., SFB1525 project A07 to D.S, TRR
332 project A7 to C.S., PO 2247/2-1 to A.P., SFB1116-project B11 to A.P. and B12
to M.K.), LMU Munich’s Institutional\r\nStrategy LMUexcellent within the framework
of the German Excellence Initiative (No. 806 32 006 to T.P.), and by the German
Centre for Cardiovascular Research (DZHK) to T.P. (Postdoc Start-up grant No. 100378833).
This project has received funding from the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation program (grant agreement
No. 833440 to S.M.). F.G. received funding from the European Union’s\r\nHorizon
2020 research and innovation program under the Marie Sk1odowska-Curie grant agreement
no. 747687. A.H. was funded by RTI2018-095497-B-I00 from Ministerio de Ciencia e
Innovacio´ n (MICINN), HR17_00527 from Fundacion La Caixa, and Transatlantic Network
of Excellence (TNE-18CVD04) from the Leducq Foundation. The CNIC is supported by
the MICINN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence
(CEX2020-001041-S). A.P. was supported by the Forschungskommission of the Medical
Faculty of the Heinrich-Heine-Universität Düsseldorf (No. 18-2019 to A.P.). C.G.
was supported by the Helmholtz Alliance ‘Aging and Metabolic Programming, AMPro,’
by the German Federal\r\nMinistry of Education and Research to the German Center
for Diabetes Research (DZD), and by the Bavarian State Ministry of Health and Care
through the research project DigiMed Bayern."
article_processing_charge: No
article_type: original
author:
- first_name: Tobias
full_name: Petzold, Tobias
last_name: Petzold
- first_name: Zhe
full_name: Zhang, Zhe
last_name: Zhang
- first_name: Iván
full_name: Ballesteros, Iván
last_name: Ballesteros
- first_name: Inas
full_name: Saleh, Inas
last_name: Saleh
- first_name: Amin
full_name: Polzin, Amin
last_name: Polzin
- first_name: Manuela
full_name: Thienel, Manuela
last_name: Thienel
- first_name: Lulu
full_name: Liu, Lulu
last_name: Liu
- first_name: Qurrat
full_name: Ul Ain, Qurrat
last_name: Ul Ain
- first_name: Vincent
full_name: Ehreiser, Vincent
last_name: Ehreiser
- first_name: Christian
full_name: Weber, Christian
last_name: Weber
- first_name: Badr
full_name: Kilani, Badr
last_name: Kilani
- first_name: Pontus
full_name: Mertsch, Pontus
last_name: Mertsch
- first_name: Jeremias
full_name: Götschke, Jeremias
last_name: Götschke
- first_name: Sophie
full_name: Cremer, Sophie
last_name: Cremer
- first_name: Wenwen
full_name: Fu, Wenwen
last_name: Fu
- first_name: Michael
full_name: Lorenz, Michael
last_name: Lorenz
- first_name: Hellen
full_name: Ishikawa-Ankerhold, Hellen
last_name: Ishikawa-Ankerhold
- first_name: Elisabeth
full_name: Raatz, Elisabeth
last_name: Raatz
- first_name: Shaza
full_name: El-Nemr, Shaza
last_name: El-Nemr
- first_name: Agnes
full_name: Görlach, Agnes
last_name: Görlach
- first_name: Esther
full_name: Marhuenda, Esther
last_name: Marhuenda
- first_name: Konstantin
full_name: Stark, Konstantin
last_name: Stark
- first_name: Joachim
full_name: Pircher, Joachim
last_name: Pircher
- first_name: David
full_name: Stegner, David
last_name: Stegner
- first_name: Christian
full_name: Gieger, Christian
last_name: Gieger
- first_name: Marc
full_name: Schmidt-Supprian, Marc
last_name: Schmidt-Supprian
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Isaac
full_name: Almendros, Isaac
last_name: Almendros
- first_name: Malte
full_name: Kelm, Malte
last_name: Kelm
- first_name: Christian
full_name: Schulz, Christian
last_name: Schulz
- first_name: Andrés
full_name: Hidalgo, Andrés
last_name: Hidalgo
- first_name: Steffen
full_name: Massberg, Steffen
last_name: Massberg
citation:
ama: Petzold T, Zhang Z, Ballesteros I, et al. Neutrophil “plucking” on megakaryocytes
drives platelet production and boosts cardiovascular disease. Immunity.
2022;55(12):2285-2299.e7. doi:10.1016/j.immuni.2022.10.001
apa: Petzold, T., Zhang, Z., Ballesteros, I., Saleh, I., Polzin, A., Thienel, M.,
… Massberg, S. (2022). Neutrophil “plucking” on megakaryocytes drives platelet
production and boosts cardiovascular disease. Immunity. Elsevier. https://doi.org/10.1016/j.immuni.2022.10.001
chicago: Petzold, Tobias, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin,
Manuela Thienel, Lulu Liu, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives
Platelet Production and Boosts Cardiovascular Disease.” Immunity. Elsevier,
2022. https://doi.org/10.1016/j.immuni.2022.10.001.
ieee: T. Petzold et al., “Neutrophil ‘plucking’ on megakaryocytes drives
platelet production and boosts cardiovascular disease,” Immunity, vol.
55, no. 12. Elsevier, p. 2285–2299.e7, 2022.
ista: Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul
Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz
M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K,
Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gärtner FR, Almendros I, Kelm
M, Schulz C, Hidalgo A, Massberg S. 2022. Neutrophil “plucking” on megakaryocytes
drives platelet production and boosts cardiovascular disease. Immunity. 55(12),
2285–2299.e7.
mla: Petzold, Tobias, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives Platelet
Production and Boosts Cardiovascular Disease.” Immunity, vol. 55, no. 12,
Elsevier, 2022, p. 2285–2299.e7, doi:10.1016/j.immuni.2022.10.001.
short: T. Petzold, Z. Zhang, I. Ballesteros, I. Saleh, A. Polzin, M. Thienel, L.
Liu, Q. Ul Ain, V. Ehreiser, C. Weber, B. Kilani, P. Mertsch, J. Götschke, S.
Cremer, W. Fu, M. Lorenz, H. Ishikawa-Ankerhold, E. Raatz, S. El-Nemr, A. Görlach,
E. Marhuenda, K. Stark, J. Pircher, D. Stegner, C. Gieger, M. Schmidt-Supprian,
F.R. Gärtner, I. Almendros, M. Kelm, C. Schulz, A. Hidalgo, S. Massberg, Immunity
55 (2022) 2285–2299.e7.
date_created: 2023-01-12T11:56:54Z
date_published: 2022-12-13T00:00:00Z
date_updated: 2025-04-14T07:43:16Z
day: '13'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1016/j.immuni.2022.10.001
ec_funded: 1
external_id:
isi:
- '000922019600003'
pmid:
- '36272416'
file:
- access_level: open_access
checksum: 073267a9c0ad9f85a650053bc7b23777
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:18:48Z
date_updated: 2023-01-23T10:18:48Z
file_id: '12341'
file_name: 2022_Immunity_Petzold.pdf
file_size: 5299475
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:18:48Z
has_accepted_license: '1'
intvolume: ' 55'
isi: 1
issue: '12'
keyword:
- Infectious Diseases
- Immunology
- Immunology and Allergy
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 2285-2299.e7
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Immunity
publication_identifier:
issn:
- 1074-7613
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neutrophil “plucking” on megakaryocytes drives platelet production and boosts
cardiovascular disease
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2022'
...
---
OA_place: publisher
OA_type: free access
_id: '12120'
abstract:
- lang: eng
text: Plant root architecture flexibly adapts to changing nitrate (NO3−) availability
in the soil; however, the underlying molecular mechanism of this adaptive development
remains under-studied. To explore the regulation of NO3−-mediated root growth,
we screened for low-nitrate-resistant mutant (lonr) and identified mutants that
were defective in the NAC transcription factor NAC075 (lonr1) as being less sensitive
to low NO3− in terms of primary root growth. We show that NAC075 is a mobile transcription
factor relocating from the root stele tissues to the endodermis based on NO3−
availability. Under low-NO3− availability, the kinase CBL-interacting protein
kinase 1 (CIPK1) is activated, and it phosphorylates NAC075, restricting its movement
from the stele, which leads to the transcriptional regulation of downstream target
WRKY53, consequently leading to adapted root architecture. Our work thus identifies
an adaptive mechanism involving translocation of transcription factor based on
nutrient availability and leading to cell-specific reprogramming of plant root
growth.
acknowledgement: The authors are grateful to Jörg Kudla, Ying Miao, Yu Zheng, Gang
Li, and Jun Zheng for providing published materials and to Wenkun Zhou and Caifu
Jiang for helpful discussions. This work was supported by grants from the National
Key Research and Development Program of China (2021YFF1000500), the National Natural
Science Foundation of China (32170265 and 32022007), the Beijing Municipal Natural
Science Foundation (5192011), and the Chinese Universities Scientific Fund (2022TC153).
article_processing_charge: No
article_type: original
author:
- first_name: Huixin
full_name: Xiao, Huixin
last_name: Xiao
- first_name: Yumei
full_name: Hu, Yumei
last_name: Hu
- first_name: Yaping
full_name: Wang, Yaping
last_name: Wang
- first_name: Jinkui
full_name: Cheng, Jinkui
last_name: Cheng
- first_name: Jinyi
full_name: Wang, Jinyi
last_name: Wang
- first_name: Guojingwei
full_name: Chen, Guojingwei
last_name: Chen
- first_name: Qian
full_name: Li, Qian
last_name: Li
- first_name: Shuwei
full_name: Wang, Shuwei
last_name: Wang
- first_name: Yalu
full_name: Wang, Yalu
last_name: Wang
- first_name: Shao-Shuai
full_name: Wang, Shao-Shuai
last_name: Wang
- first_name: Yi
full_name: Wang, Yi
last_name: Wang
- first_name: Wei
full_name: Xuan, Wei
last_name: Xuan
- first_name: Zhen
full_name: Li, Zhen
last_name: Li
- first_name: Yan
full_name: Guo, Yan
last_name: Guo
- first_name: Zhizhong
full_name: Gong, Zhizhong
last_name: Gong
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jing
full_name: Zhang, Jing
last_name: Zhang
citation:
ama: Xiao H, Hu Y, Wang Y, et al. Nitrate availability controls translocation of
the transcription factor NAC075 for cell-type-specific reprogramming of root growth.
Developmental Cell. 2022;57(23):2638-2651.e6. doi:10.1016/j.devcel.2022.11.006
apa: Xiao, H., Hu, Y., Wang, Y., Cheng, J., Wang, J., Chen, G., … Zhang, J. (2022).
Nitrate availability controls translocation of the transcription factor NAC075
for cell-type-specific reprogramming of root growth. Developmental Cell.
Elsevier. https://doi.org/10.1016/j.devcel.2022.11.006
chicago: Xiao, Huixin, Yumei Hu, Yaping Wang, Jinkui Cheng, Jinyi Wang, Guojingwei
Chen, Qian Li, et al. “Nitrate Availability Controls Translocation of the Transcription
Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” Developmental
Cell. Elsevier, 2022. https://doi.org/10.1016/j.devcel.2022.11.006.
ieee: H. Xiao et al., “Nitrate availability controls translocation of the
transcription factor NAC075 for cell-type-specific reprogramming of root growth,”
Developmental Cell, vol. 57, no. 23. Elsevier, p. 2638–2651.e6, 2022.
ista: Xiao H, Hu Y, Wang Y, Cheng J, Wang J, Chen G, Li Q, Wang S, Wang Y, Wang
S-S, Wang Y, Xuan W, Li Z, Guo Y, Gong Z, Friml J, Zhang J. 2022. Nitrate availability
controls translocation of the transcription factor NAC075 for cell-type-specific
reprogramming of root growth. Developmental Cell. 57(23), 2638–2651.e6.
mla: Xiao, Huixin, et al. “Nitrate Availability Controls Translocation of the Transcription
Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” Developmental
Cell, vol. 57, no. 23, Elsevier, 2022, p. 2638–2651.e6, doi:10.1016/j.devcel.2022.11.006.
short: H. Xiao, Y. Hu, Y. Wang, J. Cheng, J. Wang, G. Chen, Q. Li, S. Wang, Y. Wang,
S.-S. Wang, Y. Wang, W. Xuan, Z. Li, Y. Guo, Z. Gong, J. Friml, J. Zhang, Developmental
Cell 57 (2022) 2638–2651.e6.
date_created: 2023-01-12T11:57:00Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2025-06-25T07:29:52Z
day: '05'
department:
- _id: JiFr
doi: 10.1016/j.devcel.2022.11.006
external_id:
isi:
- '000919603800005'
pmid:
- '36473460'
intvolume: ' 57'
isi: 1
issue: '23'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.devcel.2022.11.006
month: '12'
oa: 1
oa_version: Published Version
page: 2638-2651.e6
pmid: 1
publication: Developmental Cell
publication_identifier:
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nitrate availability controls translocation of the transcription factor NAC075
for cell-type-specific reprogramming of root growth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2022'
...
---
_id: '12121'
abstract:
- lang: eng
text: Autophagosomes are double-membraned vesicles that traffic harmful or unwanted
cellular macromolecules to the vacuole for recycling. Although autophagosome biogenesis
has been extensively studied, autophagosome maturation, i.e., delivery and fusion
with the vacuole, remains largely unknown in plants. Here, we have identified
an autophagy adaptor, CFS1, that directly interacts with the autophagosome marker
ATG8 and localizes on both membranes of the autophagosome. Autophagosomes form
normally in Arabidopsis thaliana cfs1 mutants, but their delivery to the vacuole
is disrupted. CFS1’s function is evolutionarily conserved in plants, as it also
localizes to the autophagosomes and plays a role in autophagic flux in the liverwort
Marchantia polymorpha. CFS1 regulates autophagic flux by bridging autophagosomes
with the multivesicular body-localized ESCRT-I component VPS23A, leading to the
formation of amphisomes. Similar to CFS1-ATG8 interaction, disrupting the CFS1-VPS23A
interaction blocks autophagic flux and renders plants sensitive to nitrogen starvation.
Altogether, our results reveal a conserved vacuolar sorting hub that regulates
autophagic flux in plants.
acknowledgement: "We thank Suayip Ustün, Karin Schumacher, Erika Isono, Gerd Juergens,
Takashi Ueda, Daniel Hofius, and Liwen Jiang for sharing published materials.\r\nWe
acknowledge funding from Austrian Academy of Sciences, Austrian Science Fund (FWF,
P 32355, P 34944), Austrian Science Fund (FWF-SFB F79), Vienna Science and Technology\r\nFund
(WWTF, LS17-047) to Y. Dagdas; Austrian Academy of Sciences DOC Fellowship to J.
Zhao, Marie Curie VIP2 Fellowship to J.C. De La Concepcion and M. Clavel; Hong Kong
Research Grant Council (GRF14121019, 14113921, AoE/M-05/12, C4002-17G) to B.-H.
Kang. We thank Vienna Biocenter Core Facilities (VBCF) Protein Chemistry, Biooptics,
Plant Sciences, Molecular Biology, and Protein Technologies. We thank J. Matthew
Watson\r\nand members of the Dagdas lab for the critical reading and editing of
the manuscript."
article_number: e202203139
article_processing_charge: No
article_type: original
author:
- first_name: Jierui
full_name: Zhao, Jierui
last_name: Zhao
- first_name: Mai Thu
full_name: Bui, Mai Thu
last_name: Bui
- first_name: Juncai
full_name: Ma, Juncai
last_name: Ma
- first_name: Fabian
full_name: Künzl, Fabian
last_name: Künzl
- first_name: Lorenzo
full_name: Picchianti, Lorenzo
last_name: Picchianti
- first_name: Juan Carlos
full_name: De La Concepcion, Juan Carlos
last_name: De La Concepcion
- first_name: Yixuan
full_name: Chen, Yixuan
last_name: Chen
- first_name: Sofia
full_name: Petsangouraki, Sofia
last_name: Petsangouraki
- first_name: Azadeh
full_name: Mohseni, Azadeh
last_name: Mohseni
- first_name: Marta
full_name: García-Leon, Marta
last_name: García-Leon
- first_name: Marta Salas
full_name: Gomez, Marta Salas
last_name: Gomez
- first_name: Caterina
full_name: Giannini, Caterina
id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
last_name: Giannini
- first_name: Dubois
full_name: Gwennogan, Dubois
last_name: Gwennogan
- first_name: Roksolana
full_name: Kobylinska, Roksolana
last_name: Kobylinska
- first_name: Marion
full_name: Clavel, Marion
last_name: Clavel
- first_name: Swen
full_name: Schellmann, Swen
last_name: Schellmann
- first_name: Yvon
full_name: Jaillais, Yvon
last_name: Jaillais
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Byung-Ho
full_name: Kang, Byung-Ho
last_name: Kang
- first_name: Yasin
full_name: Dagdas, Yasin
last_name: Dagdas
citation:
ama: Zhao J, Bui MT, Ma J, et al. Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole. Journal of Cell Biology. 2022;221(12).
doi:10.1083/jcb.202203139
apa: Zhao, J., Bui, M. T., Ma, J., Künzl, F., Picchianti, L., De La Concepcion,
J. C., … Dagdas, Y. (2022). Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole. Journal of Cell Biology. Rockefeller
University Press. https://doi.org/10.1083/jcb.202203139
chicago: Zhao, Jierui, Mai Thu Bui, Juncai Ma, Fabian Künzl, Lorenzo Picchianti,
Juan Carlos De La Concepcion, Yixuan Chen, et al. “Plant Autophagosomes Mature
into Amphisomes Prior to Their Delivery to the Central Vacuole.” Journal of
Cell Biology. Rockefeller University Press, 2022. https://doi.org/10.1083/jcb.202203139.
ieee: J. Zhao et al., “Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole,” Journal of Cell Biology, vol.
221, no. 12. Rockefeller University Press, 2022.
ista: Zhao J, Bui MT, Ma J, Künzl F, Picchianti L, De La Concepcion JC, Chen Y,
Petsangouraki S, Mohseni A, García-Leon M, Gomez MS, Giannini C, Gwennogan D,
Kobylinska R, Clavel M, Schellmann S, Jaillais Y, Friml J, Kang B-H, Dagdas Y.
2022. Plant autophagosomes mature into amphisomes prior to their delivery to the
central vacuole. Journal of Cell Biology. 221(12), e202203139.
mla: Zhao, Jierui, et al. “Plant Autophagosomes Mature into Amphisomes Prior to
Their Delivery to the Central Vacuole.” Journal of Cell Biology, vol. 221,
no. 12, e202203139, Rockefeller University Press, 2022, doi:10.1083/jcb.202203139.
short: J. Zhao, M.T. Bui, J. Ma, F. Künzl, L. Picchianti, J.C. De La Concepcion,
Y. Chen, S. Petsangouraki, A. Mohseni, M. García-Leon, M.S. Gomez, C. Giannini,
D. Gwennogan, R. Kobylinska, M. Clavel, S. Schellmann, Y. Jaillais, J. Friml,
B.-H. Kang, Y. Dagdas, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T11:57:10Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-03T14:20:15Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1083/jcb.202203139
external_id:
isi:
- '000932958800001'
pmid:
- '36260289'
file:
- access_level: open_access
checksum: 050b5cc4b25e6b94fe3e3cbfe0f5c06b
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:30:11Z
date_updated: 2023-01-23T10:30:11Z
file_id: '12342'
file_name: 2022_JCB_Zhao.pdf
file_size: 10365777
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:30:11Z
has_accepted_license: '1'
intvolume: ' 221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Plant autophagosomes mature into amphisomes prior to their delivery to the
central vacuole
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 221
year: '2022'
...
---
_id: '12122'
abstract:
- lang: eng
text: Centrosomes play a crucial role during immune cell interactions and initiation
of the immune response. In proliferating cells, centrosome numbers are tightly
controlled and generally limited to one in G1 and two prior to mitosis. Defects
in regulating centrosome numbers have been associated with cell transformation
and tumorigenesis. Here, we report the emergence of extra centrosomes in leukocytes
during immune activation. Upon antigen encounter, dendritic cells pass through
incomplete mitosis and arrest in the subsequent G1 phase leading to tetraploid
cells with accumulated centrosomes. In addition, cell stimulation increases expression
of polo-like kinase 2, resulting in diploid cells with two centrosomes in G1-arrested
cells. During cell migration, centrosomes tightly cluster and act as functional
microtubule-organizing centers allowing for increased persistent locomotion along
gradients of chemotactic cues. Moreover, dendritic cells with extra centrosomes
display enhanced secretion of inflammatory cytokines and optimized T cell responses.
Together, these results demonstrate a previously unappreciated role of extra centrosomes
for regular cell and tissue homeostasis.
acknowledgement: "We thank Markéta Dalecká and Irena Krejzová for their support with
FIB-SEM imaging, the Imaging Methods Core Facility at BIOCEV supported by the Ministry
of Education, Youth and Sports Czech Republic (Large RI Project LM2018129 Czech-BioImaging),
and European Regional Development Fund (project No. CZ.02.1.01/0.0/0.0/18_046/0016045)
for their support with obtaining imaging data presented in this paper. The authors
further thank Andreas Villunger, Florian Gärtner, Frank Bradke, and Sarah Förster
for helpful discussions; Andy Zielinski for help with statistics; and Björn Weiershausen
for assisting with figure illustration.\r\n\r\nThis work was funded by a fellowship
of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ:
421-8.03.03.02-137069) to E. Kiermaier and the Deutsche Forschungsgemeinschaft (German
Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048.
R. Hauschild was funded by grant number 2020-225401 from the Chan Zuckerberg Initiative
Donor-Advised Fund, an advised fund of Silicon Valley Community Foundation. M. Hons
is supported by Czech Science Foundation GACR 20-24603Y and Charles University PRIMUS/20/MED/013."
article_number: e202107134
article_processing_charge: No
article_type: original
author:
- first_name: Ann-Kathrin
full_name: Weier, Ann-Kathrin
last_name: Weier
- first_name: Mirka
full_name: Homrich, Mirka
last_name: Homrich
- first_name: Stephanie
full_name: Ebbinghaus, Stephanie
last_name: Ebbinghaus
- first_name: Pavel
full_name: Juda, Pavel
last_name: Juda
- first_name: Eliška
full_name: Miková, Eliška
last_name: Miková
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Lili
full_name: Zhang, Lili
last_name: Zhang
- first_name: Thomas
full_name: Quast, Thomas
last_name: Quast
- first_name: Elvira
full_name: Mass, Elvira
last_name: Mass
- first_name: Andreas
full_name: Schlitzer, Andreas
last_name: Schlitzer
- first_name: Waldemar
full_name: Kolanus, Waldemar
last_name: Kolanus
- first_name: Sven
full_name: Burgdorf, Sven
last_name: Burgdorf
- first_name: Oliver J.
full_name: Gruß, Oliver J.
last_name: Gruß
- first_name: Miroslav
full_name: Hons, Miroslav
last_name: Hons
- first_name: Stefan
full_name: Wieser, Stefan
last_name: Wieser
- first_name: Eva
full_name: Kiermaier, Eva
last_name: Kiermaier
citation:
ama: Weier A-K, Homrich M, Ebbinghaus S, et al. Multiple centrosomes enhance migration
and immune cell effector functions of mature dendritic cells. Journal of Cell
Biology. 2022;221(12). doi:10.1083/jcb.202107134
apa: Weier, A.-K., Homrich, M., Ebbinghaus, S., Juda, P., Miková, E., Hauschild,
R., … Kiermaier, E. (2022). Multiple centrosomes enhance migration and immune
cell effector functions of mature dendritic cells. Journal of Cell Biology.
Rockefeller University Press. https://doi.org/10.1083/jcb.202107134
chicago: Weier, Ann-Kathrin, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliška
Miková, Robert Hauschild, Lili Zhang, et al. “Multiple Centrosomes Enhance Migration
and Immune Cell Effector Functions of Mature Dendritic Cells.” Journal of Cell
Biology. Rockefeller University Press, 2022. https://doi.org/10.1083/jcb.202107134.
ieee: A.-K. Weier et al., “Multiple centrosomes enhance migration and immune
cell effector functions of mature dendritic cells,” Journal of Cell Biology,
vol. 221, no. 12. Rockefeller University Press, 2022.
ista: Weier A-K, Homrich M, Ebbinghaus S, Juda P, Miková E, Hauschild R, Zhang L,
Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruß OJ, Hons M, Wieser S,
Kiermaier E. 2022. Multiple centrosomes enhance migration and immune cell effector
functions of mature dendritic cells. Journal of Cell Biology. 221(12), e202107134.
mla: Weier, Ann-Kathrin, et al. “Multiple Centrosomes Enhance Migration and Immune
Cell Effector Functions of Mature Dendritic Cells.” Journal of Cell Biology,
vol. 221, no. 12, e202107134, Rockefeller University Press, 2022, doi:10.1083/jcb.202107134.
short: A.-K. Weier, M. Homrich, S. Ebbinghaus, P. Juda, E. Miková, R. Hauschild,
L. Zhang, T. Quast, E. Mass, A. Schlitzer, W. Kolanus, S. Burgdorf, O.J. Gruß,
M. Hons, S. Wieser, E. Kiermaier, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T12:01:09Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2025-04-15T08:37:41Z
day: '05'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1083/jcb.202107134
external_id:
isi:
- '000932941400001'
pmid:
- '36214847 '
file:
- access_level: open_access
checksum: 0c9af38f82af30c6ce528f2caece4246
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T11:24:53Z
date_updated: 2023-08-16T11:24:53Z
file_id: '14065'
file_name: 2023_JCB_Weier.pdf
file_size: 11090179
relation: main_file
success: 1
file_date_updated: 2023-08-16T11:24:53Z
has_accepted_license: '1'
intvolume: ' 221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiple centrosomes enhance migration and immune cell effector functions of
mature dendritic cells
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 221
year: '2022'
...
---
_id: '12128'
abstract:
- lang: eng
text: We introduce a machine-learning (ML) framework for high-throughput benchmarking
of diverse representations of chemical systems against datasets of materials and
molecules. The guiding principle underlying the benchmarking approach is to evaluate
raw descriptor performance by limiting model complexity to simple regression schemes
while enforcing best ML practices, allowing for unbiased hyperparameter optimization,
and assessing learning progress through learning curves along series of synchronized
train-test splits. The resulting models are intended as baselines that can inform
future method development, in addition to indicating how easily a given dataset
can be learnt. Through a comparative analysis of the training outcome across a
diverse set of physicochemical, topological and geometric representations, we
glean insight into the relative merits of these representations as well as their
interrelatedness.
acknowledgement: 'C P acknowledges funding from Astex through the Sustaining Innovation
Program under the Milner Consortium. B C acknowledges resources provided by the
Cambridge Tier-2 system operated by the University of Cambridge Research Computing
Service funded by EPSRC Tier-2 capital Grant EP/P020259/1. F A F acknowledges funding
from the Swiss National Science Foundation (Grant No. P2BSP2_191736). '
article_number: '040501'
article_processing_charge: No
article_type: original
author:
- first_name: Carl
full_name: Poelking, Carl
last_name: Poelking
- first_name: Felix A
full_name: Faber, Felix A
last_name: Faber
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: 'Poelking C, Faber FA, Cheng B. BenchML: An extensible pipelining framework
for benchmarking representations of materials and molecules at scale. Machine
Learning: Science and Technology. 2022;3(4). doi:10.1088/2632-2153/ac4d11'
apa: 'Poelking, C., Faber, F. A., & Cheng, B. (2022). BenchML: An extensible
pipelining framework for benchmarking representations of materials and molecules
at scale. Machine Learning: Science and Technology. IOP Publishing. https://doi.org/10.1088/2632-2153/ac4d11'
chicago: 'Poelking, Carl, Felix A Faber, and Bingqing Cheng. “BenchML: An Extensible
Pipelining Framework for Benchmarking Representations of Materials and Molecules
at Scale.” Machine Learning: Science and Technology. IOP Publishing, 2022.
https://doi.org/10.1088/2632-2153/ac4d11.'
ieee: 'C. Poelking, F. A. Faber, and B. Cheng, “BenchML: An extensible pipelining
framework for benchmarking representations of materials and molecules at scale,”
Machine Learning: Science and Technology, vol. 3, no. 4. IOP Publishing,
2022.'
ista: 'Poelking C, Faber FA, Cheng B. 2022. BenchML: An extensible pipelining framework
for benchmarking representations of materials and molecules at scale. Machine
Learning: Science and Technology. 3(4), 040501.'
mla: 'Poelking, Carl, et al. “BenchML: An Extensible Pipelining Framework for Benchmarking
Representations of Materials and Molecules at Scale.” Machine Learning: Science
and Technology, vol. 3, no. 4, 040501, IOP Publishing, 2022, doi:10.1088/2632-2153/ac4d11.'
short: 'C. Poelking, F.A. Faber, B. Cheng, Machine Learning: Science and Technology
3 (2022).'
corr_author: '1'
date_created: 2023-01-12T12:02:21Z
date_published: 2022-11-17T00:00:00Z
date_updated: 2024-10-09T21:03:32Z
day: '17'
ddc:
- '000'
department:
- _id: BiCh
doi: 10.1088/2632-2153/ac4d11
external_id:
isi:
- '000886534000001'
file:
- access_level: open_access
checksum: 8930d4ad6ed9b47358c6f1a68666adb6
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:42:04Z
date_updated: 2023-01-23T10:42:04Z
file_id: '12343'
file_name: 2022_MachLearning_Poelking.pdf
file_size: 13814559
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:42:04Z
has_accepted_license: '1'
intvolume: ' 3'
isi: 1
issue: '4'
keyword:
- Artificial Intelligence
- Human-Computer Interaction
- Software
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: 'Machine Learning: Science and Technology'
publication_identifier:
issn:
- 2632-2153
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/capoe/benchml
scopus_import: '1'
status: public
title: 'BenchML: An extensible pipelining framework for benchmarking representations
of materials and molecules at scale'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2022'
...
---
_id: '12129'
abstract:
- lang: eng
text: 'Given a finite point set P in general position in the plane, a full triangulation
of P is a maximal straight-line embedded plane graph on P. A partial triangulation
of P is a full triangulation of some subset P′ of P containing all extreme points
in P. A bistellar flip on a partial triangulation either flips an edge (called
edge flip), removes a non-extreme point of degree 3, or adds a point in P∖P′ as
vertex of degree 3. The bistellar flip graph has all partial triangulations as
vertices, and a pair of partial triangulations is adjacent if they can be obtained
from one another by a bistellar flip. The edge flip graph is defined with full
triangulations as vertices, and edge flips determining the adjacencies. Lawson
showed in the early seventies that these graphs are connected. The goal of this
paper is to investigate the structure of these graphs, with emphasis on their
vertex connectivity. For sets P of n points in the plane in general position,
we show that the edge flip graph is ⌈n/2−2⌉-vertex connected, and the bistellar
flip graph is (n−3)-vertex connected; both results are tight. The latter bound
matches the situation for the subfamily of regular triangulations (i.e., partial
triangulations obtained by lifting the points to 3-space and projecting back the
lower convex hull), where (n−3)-vertex connectivity has been known since the late
eighties through the secondary polytope due to Gelfand, Kapranov, & Zelevinsky
and Balinski’s Theorem. For the edge flip-graph, we additionally show that the
vertex connectivity is at least as large as (and hence equal to) the minimum degree
(i.e., the minimum number of flippable edges in any full triangulation), provided
that n is large enough. Our methods also yield several other results: (i) The
edge flip graph can be covered by graphs of polytopes of dimension ⌈n/2−2⌉ (products
of associahedra) and the bistellar flip graph can be covered by graphs of polytopes
of dimension n−3 (products of secondary polytopes). (ii) A partial triangulation
is regular, if it has distance n−3 in the Hasse diagram of the partial order of
partial subdivisions from the trivial subdivision. (iii) All partial triangulations
of a point set are regular iff the partial order of partial subdivisions has height
n−3. (iv) There are arbitrarily large sets P with non-regular partial triangulations
and such that every proper subset has only regular triangulations, i.e., there
are no small certificates for the existence of non-regular triangulations.'
acknowledgement: "This is a full and revised version of [38] (on partial triangulations)
in Proceedings of the 36th Annual International Symposium on Computational Geometry
(SoCG‘20) and of some of the results in [37] (on full triangulations) in Proceedings
of the 31st Annual ACM-SIAM Symposium on Discrete Algorithms (SODA‘20).\r\nThis
research started at the 11th Gremo’s Workshop on Open Problems (GWOP), Alp Sellamatt,
Switzerland, June 24–28, 2013, motivated by a question posed by Filip Mori´c on
full triangulations. Research was supported by the Swiss National Science Foundation
within the collaborative DACH project Arrangements and Drawings as SNSF Project
200021E-171681, and by IST Austria and Berlin Free University during a sabbatical
stay of the second author. We thank Michael Joswig, Jesús De Loera, and Francisco
Santos for helpful discussions on the topics of this paper, and Daniel Bertschinger
and Valentin Stoppiello for carefully reading earlier versions and for many helpful
comments.\r\nOpen access funding provided by the Swiss Federal Institute of Technology
Zürich"
article_processing_charge: No
article_type: original
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Wagner U, Welzl E. Connectivity of triangulation flip graphs in the plane.
Discrete & Computational Geometry. 2022;68(4):1227-1284. doi:10.1007/s00454-022-00436-2
apa: Wagner, U., & Welzl, E. (2022). Connectivity of triangulation flip graphs
in the plane. Discrete & Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-022-00436-2
chicago: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs
in the Plane.” Discrete & Computational Geometry. Springer Nature,
2022. https://doi.org/10.1007/s00454-022-00436-2.
ieee: U. Wagner and E. Welzl, “Connectivity of triangulation flip graphs in the
plane,” Discrete & Computational Geometry, vol. 68, no. 4. Springer
Nature, pp. 1227–1284, 2022.
ista: Wagner U, Welzl E. 2022. Connectivity of triangulation flip graphs in the
plane. Discrete & Computational Geometry. 68(4), 1227–1284.
mla: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs in the
Plane.” Discrete & Computational Geometry, vol. 68, no. 4, Springer
Nature, 2022, pp. 1227–84, doi:10.1007/s00454-022-00436-2.
short: U. Wagner, E. Welzl, Discrete & Computational Geometry 68 (2022) 1227–1284.
corr_author: '1'
date_created: 2023-01-12T12:02:28Z
date_published: 2022-11-14T00:00:00Z
date_updated: 2025-07-10T11:54:56Z
day: '14'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1007/s00454-022-00436-2
external_id:
isi:
- '000883222200003'
file:
- access_level: open_access
checksum: 307e879d09e52eddf5b225d0aaa9213a
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:10:03Z
date_updated: 2023-01-23T11:10:03Z
file_id: '12345'
file_name: 2022_DiscreteCompGeometry_Wagner.pdf
file_size: 1747581
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:10:03Z
has_accepted_license: '1'
intvolume: ' 68'
isi: 1
issue: '4'
keyword:
- Computational Theory and Mathematics
- Discrete Mathematics and Combinatorics
- Geometry and Topology
- Theoretical Computer Science
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1227-1284
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '7807'
relation: earlier_version
status: public
- id: '7990'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Connectivity of triangulation flip graphs in the plane
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 68
year: '2022'
...
---
_id: '12130'
abstract:
- lang: eng
text: Germline determination is essential for species survival and evolution in
multicellular organisms. In most flowering plants, formation of the female germline
is initiated with specification of one megaspore mother cell (MMC) in each ovule;
however, the molecular mechanism underlying this key event remains unclear. Here
we report that spatially restricted auxin signaling promotes MMC fate in Arabidopsis.
Our results show that the microRNA160 (miR160) targeted gene ARF17 (AUXIN RESPONSE
FACTOR17) is required for promoting MMC specification by genetically interacting
with the SPL/NZZ (SPOROCYTELESS/NOZZLE) gene. Alterations of auxin signaling cause
formation of supernumerary MMCs in an ARF17- and SPL/NZZ-dependent manner. Furthermore,
miR160 and ARF17 are indispensable for attaining a normal auxin maximum at the
ovule apex via modulating the expression domain of PIN1 (PIN-FORMED1) auxin transporter.
Our findings elucidate the mechanism by which auxin signaling promotes the acquisition
of female germline cell fate in plants.
acknowledgement: "We thank A. Cheung,W. Lukowitz, V.Walbot, D.Weijers, and R. Yadegari
for critically reading the manuscript; E. Xiong and G. Zhang for preparing some
experiments, T. Schuck, J. Gonnering, and P. Engevold for plant care, the Arabidopsis
Biological Resource Center (ABRC) for ARF10,ARF16, ARF17, EMS1,MIR160a BAC clones
and cDNAs, the SALK_090804 seed, T. Nakagawa for pGBW vectors, Y. Zhao for the YUC1
cDNA, Q. Chen for the pHEE401E vector, R. Yadegari for pAT5G01860::n1GFP, pAT5G45980:n1GFP,
pAT5G50490::n1GFP, pAT5G56200:n1GFP vectors, and D.Weijers for the pGreenII KAN
SV40-3×GFP and R2D2 vectors, W. Yang for the splmutant, Y. Qin for the pKNU::KNU-VENUS
vector and seed, G. Tang for the STTM160/160-48 vector, and L. Colombo for pPIN1::PIN1-GFP
spl and pin1-5 seeds. This work was supported by the US National Science Foundation
(NSF)-Israel Binational Science Foundation (BSF) research grant to D.Z. (IOS-1322796)
and T.A. (2012756). D.Z. also\r\ngratefully acknowledges supports of the Shaw Scientist
Award from the Greater Milwaukee Foundation, USDA National Institute of Food and
Agriculture (NIFA, 2022-67013-36294), the UWM Discovery and Innovation Grant, the
Bradley Catalyst Award from the UWM Research\r\nFoundation, and WiSys and UW System
Applied Research Funding Programs."
article_number: '6960'
article_processing_charge: No
article_type: original
author:
- first_name: Jian
full_name: Huang, Jian
last_name: Huang
- first_name: Lei
full_name: Zhao, Lei
last_name: Zhao
- first_name: Shikha
full_name: Malik, Shikha
last_name: Malik
- first_name: Benjamin R.
full_name: Gentile, Benjamin R.
last_name: Gentile
- first_name: Va
full_name: Xiong, Va
last_name: Xiong
- first_name: Tzahi
full_name: Arazi, Tzahi
last_name: Arazi
- first_name: Heather A.
full_name: Owen, Heather A.
last_name: Owen
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Dazhong
full_name: Zhao, Dazhong
last_name: Zhao
citation:
ama: Huang J, Zhao L, Malik S, et al. Specification of female germline by microRNA
orchestrated auxin signaling in Arabidopsis. Nature Communications. 2022;13.
doi:10.1038/s41467-022-34723-6
apa: Huang, J., Zhao, L., Malik, S., Gentile, B. R., Xiong, V., Arazi, T., … Zhao,
D. (2022). Specification of female germline by microRNA orchestrated auxin signaling
in Arabidopsis. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-34723-6
chicago: Huang, Jian, Lei Zhao, Shikha Malik, Benjamin R. Gentile, Va Xiong, Tzahi
Arazi, Heather A. Owen, Jiří Friml, and Dazhong Zhao. “Specification of Female
Germline by MicroRNA Orchestrated Auxin Signaling in Arabidopsis.” Nature Communications.
Springer Nature, 2022. https://doi.org/10.1038/s41467-022-34723-6.
ieee: J. Huang et al., “Specification of female germline by microRNA orchestrated
auxin signaling in Arabidopsis,” Nature Communications, vol. 13. Springer
Nature, 2022.
ista: Huang J, Zhao L, Malik S, Gentile BR, Xiong V, Arazi T, Owen HA, Friml J,
Zhao D. 2022. Specification of female germline by microRNA orchestrated auxin
signaling in Arabidopsis. Nature Communications. 13, 6960.
mla: Huang, Jian, et al. “Specification of Female Germline by MicroRNA Orchestrated
Auxin Signaling in Arabidopsis.” Nature Communications, vol. 13, 6960,
Springer Nature, 2022, doi:10.1038/s41467-022-34723-6.
short: J. Huang, L. Zhao, S. Malik, B.R. Gentile, V. Xiong, T. Arazi, H.A. Owen,
J. Friml, D. Zhao, Nature Communications 13 (2022).
date_created: 2023-01-12T12:02:41Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2025-07-08T09:01:02Z
day: '15'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41467-022-34723-6
external_id:
isi:
- '000884426700001'
pmid:
- '36379956'
file:
- access_level: open_access
checksum: 233922a7b9507d9d48591e6799e4526e
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:17:33Z
date_updated: 2023-01-23T11:17:33Z
file_id: '12346'
file_name: 2022_NatureCommunications_Huang.pdf
file_size: 3375249
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:17:33Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
- Multidisciplinary
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Specification of female germline by microRNA orchestrated auxin signaling in
Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2022'
...
---
_id: '12131'
abstract:
- lang: eng
text: Replication-incompetent adenoviral vectors have been extensively used as a
platform for vaccine design, with at least four anti-COVID-19 vaccines authorized
to date. These vaccines elicit neutralizing antibody responses directed against
SARS-CoV-2 Spike protein and confer significant level of protection against SARS-CoV-2
infection. Immunization with adenovirus-vectored vaccines is known to be accompanied
by the production of anti-vector antibodies, which may translate into reduced
efficacy of booster or repeated rounds of revaccination. Here, we used blood samples
from patients who received an adenovirus-based Gam-COVID-Vac vaccine to address
the question of whether anti-vector antibodies may influence the magnitude of
SARS-CoV-2-specific humoral response after booster vaccination. We observed that
rAd26-based prime vaccination with Gam-COVID-Vac induced the development of Ad26-neutralizing
antibodies, which persisted in circulation for at least 9 months. Our analysis
further indicates that high pre-boost Ad26 neutralizing antibody titers do not
appear to affect the humoral immunogenicity of the Gam-COVID-Vac boost. The titers
of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type
and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron,
were independent of the pre-boost levels of Ad26-neutralizing antibodies. Thus,
our results support the development of repeated immunization schedule with adenovirus-based
COVID-19 vaccines.
acknowledgement: We thank Sergey Kulemzin, Grigory Efimov, Yuri Lebedin, Alexander
Taranin and Rudolf Valenta for providing reagents. Figures were created with the
help of BioRender.com. This work was supported by the Russian Science Foundation
(Project 21-15-00286). Byazrova M.G. was supported by the RUDN University Strategic
Academic Leadership Program.
article_number: '145'
article_processing_charge: No
article_type: original
author:
- first_name: Maria G.
full_name: Byazrova, Maria G.
last_name: Byazrova
- first_name: Ekaterina A.
full_name: Astakhova, Ekaterina A.
last_name: Astakhova
- first_name: Aygul
full_name: Minnegalieva, Aygul
id: 87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
last_name: Minnegalieva
- first_name: Maria M.
full_name: Sukhova, Maria M.
last_name: Sukhova
- first_name: Artem A.
full_name: Mikhailov, Artem A.
last_name: Mikhailov
- first_name: Alexey G.
full_name: Prilipov, Alexey G.
last_name: Prilipov
- first_name: Andrey A.
full_name: Gorchakov, Andrey A.
last_name: Gorchakov
- first_name: Alexander V.
full_name: Filatov, Alexander V.
last_name: Filatov
citation:
ama: Byazrova MG, Astakhova EA, Minnegalieva A, et al. Anti-Ad26 humoral immunity
does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
booster vaccination. npj Vaccines. 2022;7. doi:10.1038/s41541-022-00566-x
apa: Byazrova, M. G., Astakhova, E. A., Minnegalieva, A., Sukhova, M. M., Mikhailov,
A. A., Prilipov, A. G., … Filatov, A. V. (2022). Anti-Ad26 humoral immunity does
not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
booster vaccination. Npj Vaccines. Springer Nature. https://doi.org/10.1038/s41541-022-00566-x
chicago: Byazrova, Maria G., Ekaterina A. Astakhova, Aygul Minnegalieva, Maria M.
Sukhova, Artem A. Mikhailov, Alexey G. Prilipov, Andrey A. Gorchakov, and Alexander
V. Filatov. “Anti-Ad26 Humoral Immunity Does Not Compromise SARS-COV-2 Neutralizing
Antibody Responses Following Gam-COVID-Vac Booster Vaccination.” Npj Vaccines.
Springer Nature, 2022. https://doi.org/10.1038/s41541-022-00566-x.
ieee: M. G. Byazrova et al., “Anti-Ad26 humoral immunity does not compromise
SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination,”
npj Vaccines, vol. 7. Springer Nature, 2022.
ista: Byazrova MG, Astakhova EA, Minnegalieva A, Sukhova MM, Mikhailov AA, Prilipov
AG, Gorchakov AA, Filatov AV. 2022. Anti-Ad26 humoral immunity does not compromise
SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination.
npj Vaccines. 7, 145.
mla: Byazrova, Maria G., et al. “Anti-Ad26 Humoral Immunity Does Not Compromise
SARS-COV-2 Neutralizing Antibody Responses Following Gam-COVID-Vac Booster Vaccination.”
Npj Vaccines, vol. 7, 145, Springer Nature, 2022, doi:10.1038/s41541-022-00566-x.
short: M.G. Byazrova, E.A. Astakhova, A. Minnegalieva, M.M. Sukhova, A.A. Mikhailov,
A.G. Prilipov, A.A. Gorchakov, A.V. Filatov, Npj Vaccines 7 (2022).
date_created: 2023-01-12T12:02:54Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2023-08-04T08:52:40Z
day: '15'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1038/s41541-022-00566-x
external_id:
isi:
- '000884278600004'
pmid:
- '36379998'
file:
- access_level: open_access
checksum: ddaac096381565b2b4b7dcc34cdbc4ee
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:22:09Z
date_updated: 2023-01-23T11:22:09Z
file_id: '12347'
file_name: 2022_njpVaccines_Byazrova.pdf
file_size: 1856046
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:22:09Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
keyword:
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Immunology
- SARS-COV-2
- COVID
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Vaccines
publication_identifier:
issn:
- 2059-0105
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody
responses following Gam-COVID-Vac booster vaccination
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2022'
...