---
_id: '11991'
abstract:
- lang: eng
  text: The study of the complexity of the constraint satisfaction problem (CSP),
    centred around the Feder-Vardi Dichotomy Conjecture, has been very prominent in
    the last two decades. After a long concerted effort and many partial results,
    the Dichotomy Conjecture has been proved in 2017 independently by Bulatov and
    Zhuk. At about the same time, a vast generalisation of CSP, called promise CSP,
    has started to gain prominence. In this survey, we explain the importance of promise
    CSP and highlight many new very interesting features that the study of promise
    CSP has brought to light. The complexity classification quest for the promise
    CSP is wide open, and we argue that, despite the promise CSP being more general,
    this quest is rather more accessible to a wide range of researchers than the dichotomy-led
    study of the CSP has been.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Andrei
  full_name: Krokhin, Andrei
  last_name: Krokhin
- first_name: Jakub
  full_name: Opršal, Jakub
  id: ec596741-c539-11ec-b829-c79322a91242
  last_name: Opršal
  orcid: 0000-0003-1245-3456
citation:
  ama: Krokhin A, Opršal J. An invitation to the promise constraint satisfaction problem.
    <i>ACM SIGLOG News</i>. 2022;9(3):30-59. doi:<a href="https://doi.org/10.1145/3559736.3559740">10.1145/3559736.3559740</a>
  apa: Krokhin, A., &#38; Opršal, J. (2022). An invitation to the promise constraint
    satisfaction problem. <i>ACM SIGLOG News</i>. Association for Computing Machinery.
    <a href="https://doi.org/10.1145/3559736.3559740">https://doi.org/10.1145/3559736.3559740</a>
  chicago: Krokhin, Andrei, and Jakub Opršal. “An Invitation to the Promise Constraint
    Satisfaction Problem.” <i>ACM SIGLOG News</i>. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3559736.3559740">https://doi.org/10.1145/3559736.3559740</a>.
  ieee: A. Krokhin and J. Opršal, “An invitation to the promise constraint satisfaction
    problem,” <i>ACM SIGLOG News</i>, vol. 9, no. 3. Association for Computing Machinery,
    pp. 30–59, 2022.
  ista: Krokhin A, Opršal J. 2022. An invitation to the promise constraint satisfaction
    problem. ACM SIGLOG News. 9(3), 30–59.
  mla: Krokhin, Andrei, and Jakub Opršal. “An Invitation to the Promise Constraint
    Satisfaction Problem.” <i>ACM SIGLOG News</i>, vol. 9, no. 3, Association for
    Computing Machinery, 2022, pp. 30–59, doi:<a href="https://doi.org/10.1145/3559736.3559740">10.1145/3559736.3559740</a>.
  short: A. Krokhin, J. Opršal, ACM SIGLOG News 9 (2022) 30–59.
date_created: 2022-08-27T11:23:37Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2022-09-05T08:19:38Z
day: '01'
department:
- _id: UlWa
doi: 10.1145/3559736.3559740
external_id:
  arxiv:
  - '2208.13538'
fulldoi: https://doi.org/10.1145/3559736.3559740
intvolume: '         9'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/2208.13538
month: '07'
oa: 1
oa_version: Preprint
page: 30-59
publication: ACM SIGLOG News
publication_identifier:
  issn:
  - 2372-3491
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: An invitation to the promise constraint satisfaction problem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2022'
...
---
_id: '11993'
abstract:
- lang: eng
  text: Moulding refers to a set of manufacturing techniques in which a mould, usually
    a cavity or a solid frame, is used to shape a liquid or pliable material into
    an object of the desired shape. The popularity of moulding comes from its effectiveness,
    scalability and versatility in terms of employed materials. Its relevance as a
    fabrication process is demonstrated by the extensive literature covering different
    aspects related to mould design, from material flow simulation to the automation
    of mould geometry design. In this state-of-the-art report, we provide an extensive
    review of the automatic methods for the design of moulds, focusing on contributions
    from a geometric perspective. We classify existing mould design methods based
    on their computational approach and the nature of their target moulding process.
    We summarize the relationships between computational approaches and moulding techniques,
    highlighting their strengths and limitations. Finally, we discuss potential future
    research directions.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
  full_name: Alderighi, Thomas
  last_name: Alderighi
- first_name: Luigi
  full_name: Malomo, Luigi
  last_name: Malomo
- first_name: Thomas
  full_name: Auzinger, Thomas
  id: 4718F954-F248-11E8-B48F-1D18A9856A87
  last_name: Auzinger
  orcid: 0000-0002-1546-3265
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Paulo
  full_name: Cignoni, Paulo
  last_name: Cignoni
- first_name: Nico
  full_name: Pietroni, Nico
  last_name: Pietroni
citation:
  ama: Alderighi T, Malomo L, Auzinger T, Bickel B, Cignoni P, Pietroni N. State of
    the art in computational mould design. <i>Computer Graphics Forum</i>. 2022;41(6):435-452.
    doi:<a href="https://doi.org/10.1111/cgf.14581">10.1111/cgf.14581</a>
  apa: Alderighi, T., Malomo, L., Auzinger, T., Bickel, B., Cignoni, P., &#38; Pietroni,
    N. (2022). State of the art in computational mould design. <i>Computer Graphics
    Forum</i>. Wiley. <a href="https://doi.org/10.1111/cgf.14581">https://doi.org/10.1111/cgf.14581</a>
  chicago: Alderighi, Thomas, Luigi Malomo, Thomas Auzinger, Bernd Bickel, Paulo Cignoni,
    and Nico Pietroni. “State of the Art in Computational Mould Design.” <i>Computer
    Graphics Forum</i>. Wiley, 2022. <a href="https://doi.org/10.1111/cgf.14581">https://doi.org/10.1111/cgf.14581</a>.
  ieee: T. Alderighi, L. Malomo, T. Auzinger, B. Bickel, P. Cignoni, and N. Pietroni,
    “State of the art in computational mould design,” <i>Computer Graphics Forum</i>,
    vol. 41, no. 6. Wiley, pp. 435–452, 2022.
  ista: Alderighi T, Malomo L, Auzinger T, Bickel B, Cignoni P, Pietroni N. 2022.
    State of the art in computational mould design. Computer Graphics Forum. 41(6),
    435–452.
  mla: Alderighi, Thomas, et al. “State of the Art in Computational Mould Design.”
    <i>Computer Graphics Forum</i>, vol. 41, no. 6, Wiley, 2022, pp. 435–52, doi:<a
    href="https://doi.org/10.1111/cgf.14581">10.1111/cgf.14581</a>.
  short: T. Alderighi, L. Malomo, T. Auzinger, B. Bickel, P. Cignoni, N. Pietroni,
    Computer Graphics Forum 41 (2022) 435–452.
corr_author: '1'
date_created: 2022-08-28T18:17:01Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2024-10-09T21:03:21Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1111/cgf.14581
external_id:
  isi:
  - '000842638900001'
file:
- access_level: open_access
  checksum: c40cc8ceb7b7f0512172b883d712198e
  content_type: application/pdf
  creator: bbickel
  date_created: 2022-08-28T18:18:08Z
  date_updated: 2022-08-28T18:18:08Z
  description: 'This is the pre-peer reviewed version of the following article: Alderighi,
    T., Malomo, L., Auzinger, T., Bickel, B., Cignoni, P. and Pietroni, N. (2022),
    State of the Art in Computational Mould Design. Computer Graphics Forum, which
    has been published in final form at https://doi.org/10.1111/cgf.14581. This article
    may be used for non-commercial purposes in accordance with Wiley Terms and Conditions
    for Use of Self-Archived Versions.'
  file_id: '11994'
  file_name: star_molding_preprint.pdf
  file_size: 32480850
  relation: main_file
  title: pre-peer reviewed version
file_date_updated: 2022-08-28T18:18:08Z
fulldoi: https://doi.org/10.1111/cgf.14581
has_accepted_license: '1'
intvolume: '        41'
isi: 1
issue: '6'
keyword:
- Computer Graphics and Computer-Aided Design
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 435-452
publication: Computer Graphics Forum
publication_identifier:
  eissn:
  - 1467-8659
  issn:
  - 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: State of the art in computational mould design
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2022'
...
---
_id: '11995'
abstract:
- lang: eng
  text: G protein-coupled receptors (GPCRs) regulate processes ranging from immune
    responses to neuronal signaling. However, ligands for many GPCRs remain unknown,
    suffer from off-target effects or have poor bioavailability. Additionally, dissecting
    cell type-specific responses is challenging when the same GPCR is expressed on
    different cells within a tissue. Here, we overcome these limitations by engineering
    DREADD-based GPCR chimeras that bind clozapine-N-oxide and mimic a GPCR-of-interest.
    We show that chimeric DREADD-β2AR triggers responses comparable to β2AR on second
    messenger and kinase activity, post-translational modifications, and protein-protein
    interactions. Moreover, we successfully recapitulate β2AR-mediated filopodia formation
    in microglia, an immune cell capable of driving central nervous system inflammation.
    When dissecting microglial inflammation, we included two additional DREADD-based
    chimeras mimicking microglia-enriched GPR65 and GPR109A. DREADD-β2AR and DREADD-GPR65
    modulate the inflammatory response with high similarity to endogenous β2AR, while
    DREADD-GPR109A shows no impact. Our DREADD-based approach allows investigation
    of cell type-dependent pathways without known endogenous ligands.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: LifeSc
acknowledgement: The authors thank the Scientific Service Units at ISTA, in particular
  the Molecular Biology Service of the Lab Support Facility, Imaging & Optics Facility,
  and the Preclinical Facility, and the Novarino group, Harald Janoviak, and Marco
  Benevento for sharing reagents and expertise. This research was supported by a DOC
  Fellowship (24979) awarded to R.S. by the Austrian Academy of Sciences.
article_number: '4728'
article_processing_charge: No
article_type: original
author:
- first_name: Rouven
  full_name: Schulz, Rouven
  id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
  last_name: Schulz
  orcid: 0000-0001-5297-733X
- first_name: Medina
  full_name: Korkut, Medina
  id: 4B51CE74-F248-11E8-B48F-1D18A9856A87
  last_name: Korkut
  orcid: 0000-0003-4309-2251
- first_name: Alessandro
  full_name: Venturino, Alessandro
  id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
  last_name: Venturino
  orcid: 0000-0003-2356-9403
- first_name: Gloria
  full_name: Colombo, Gloria
  id: 3483CF6C-F248-11E8-B48F-1D18A9856A87
  last_name: Colombo
  orcid: 0000-0001-9434-8902
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
citation:
  ama: Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. Chimeric GPCRs mimic
    distinct signaling pathways and modulate microglia responses. <i>Nature Communications</i>.
    2022;13. doi:<a href="https://doi.org/10.1038/s41467-022-32390-1">10.1038/s41467-022-32390-1</a>
  apa: Schulz, R., Korkut, M., Venturino, A., Colombo, G., &#38; Siegert, S. (2022).
    Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.
    <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-022-32390-1">https://doi.org/10.1038/s41467-022-32390-1</a>
  chicago: Schulz, Rouven, Medina Korkut, Alessandro Venturino, Gloria Colombo, and
    Sandra Siegert. “Chimeric GPCRs Mimic Distinct Signaling Pathways and Modulate
    Microglia Responses.” <i>Nature Communications</i>. Springer Nature, 2022. <a
    href="https://doi.org/10.1038/s41467-022-32390-1">https://doi.org/10.1038/s41467-022-32390-1</a>.
  ieee: R. Schulz, M. Korkut, A. Venturino, G. Colombo, and S. Siegert, “Chimeric
    GPCRs mimic distinct signaling pathways and modulate microglia responses,” <i>Nature
    Communications</i>, vol. 13. Springer Nature, 2022.
  ista: Schulz R, Korkut M, Venturino A, Colombo G, Siegert S. 2022. Chimeric GPCRs
    mimic distinct signaling pathways and modulate microglia responses. Nature Communications.
    13, 4728.
  mla: Schulz, Rouven, et al. “Chimeric GPCRs Mimic Distinct Signaling Pathways and
    Modulate Microglia Responses.” <i>Nature Communications</i>, vol. 13, 4728, Springer
    Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-32390-1">10.1038/s41467-022-32390-1</a>.
  short: R. Schulz, M. Korkut, A. Venturino, G. Colombo, S. Siegert, Nature Communications
    13 (2022).
corr_author: '1'
date_created: 2022-08-28T22:01:59Z
date_published: 2022-08-15T00:00:00Z
date_updated: 2026-04-07T14:17:58Z
day: '15'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.1038/s41467-022-32390-1
external_id:
  isi:
  - '000840984400032'
  pmid:
  - '35970889'
file:
- access_level: open_access
  checksum: 191d9db0266e14a28d3a56dc7f65da84
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-08-29T06:44:30Z
  date_updated: 2022-08-29T06:44:30Z
  file_id: '12002'
  file_name: 2022_NatComm_Schulz.pdf
  file_size: 7317396
  relation: main_file
  success: 1
file_date_updated: 2022-08-29T06:44:30Z
fulldoi: https://doi.org/10.1038/s41467-022-32390-1
has_accepted_license: '1'
intvolume: '        13'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 267F75D8-B435-11E9-9278-68D0E5697425
  name: Modulating microglia through G protein-coupled receptor (GPCR) signaling
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/dreaddful-mimicry/
  record:
  - id: '11542'
    relation: research_data
    status: public
  - id: '11945'
    relation: part_of_dissertation
    status: public
scopus_import: '1'
status: public
title: Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11996'
abstract:
- lang: eng
  text: If you mix fruit syrups with alcohol to make a schnapps, the two liquids will
    remain perfectly blended forever. But if you mix oil with vinegar to make a vinaigrette,
    the oil and vinegar will soon separate back into their previous selves. Such liquid-liquid
    phase separation is a thermodynamically driven phenomenon and plays an important
    role in many biological processes (1). Although energy injection at the macroscale
    can reverse the phase separation—a strong shake is the normal response to a separated
    vinaigrette—little is known about the effect of energy added at the microscopic
    level on phase separation. This fundamental question has deep ramifications, notably
    in biology, because active processes also make the interior of a living cell different
    from a dead one. On page 768 of this issue, Adkins et al. (2) examine how mechanical
    activity at the microscopic scale affects liquid-liquid phase separation and allows
    liquids to climb surfaces.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Jérémie A
  full_name: Palacci, Jérémie A
  id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
  last_name: Palacci
  orcid: 0000-0002-7253-9465
citation:
  ama: Palacci JA. A soft active matter that can climb walls. <i>Science</i>. 2022;377(6607):710-711.
    doi:<a href="https://doi.org/10.1126/science.adc9202">10.1126/science.adc9202</a>
  apa: Palacci, J. A. (2022). A soft active matter that can climb walls. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.adc9202">https://doi.org/10.1126/science.adc9202</a>
  chicago: Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>.
    American Association for the Advancement of Science, 2022. <a href="https://doi.org/10.1126/science.adc9202">https://doi.org/10.1126/science.adc9202</a>.
  ieee: J. A. Palacci, “A soft active matter that can climb walls,” <i>Science</i>,
    vol. 377, no. 6607. American Association for the Advancement of Science, pp. 710–711,
    2022.
  ista: Palacci JA. 2022. A soft active matter that can climb walls. Science. 377(6607),
    710–711.
  mla: Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>,
    vol. 377, no. 6607, American Association for the Advancement of Science, 2022,
    pp. 710–11, doi:<a href="https://doi.org/10.1126/science.adc9202">10.1126/science.adc9202</a>.
  short: J.A. Palacci, Science 377 (2022) 710–711.
corr_author: '1'
date_created: 2022-08-28T22:02:00Z
date_published: 2022-08-12T00:00:00Z
date_updated: 2024-10-09T21:03:21Z
day: '12'
department:
- _id: JePa
doi: 10.1126/science.adc9202
external_id:
  pmid:
  - '35951689 '
fulldoi: https://doi.org/10.1126/science.adc9202
intvolume: '       377'
issue: '6607'
language:
- iso: eng
month: '08'
oa_version: None
page: 710-711
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: A soft active matter that can climb walls
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 377
year: '2022'
...
---
_id: '11997'
abstract:
- lang: eng
  text: "We study the fate of an impurity in an ultracold heteronuclear Bose mixture,
    focusing on the experimentally relevant case of a ⁴¹K - ⁸⁷Rb mixture, with the
    impurity in a ⁴¹K hyperfine state. Our paper provides a comprehensive description
    of an impurity in a BEC mixture with contact interactions across its phase diagram.
    We present results for the miscible and immiscible regimes, as well as for the
    impurity in a self-bound quantum droplet. Here, varying the interactions, we find
    exotic states where the impurity localizes either at the center or\r\nat the surface
    of the droplet. "
acknowledgement: We thank A. Simoni for providing the calculations of the intercomponent
  scattering lengths. We gratefully acknowledge stimulating discussions with L. A.
  Peña Ardila, R. Schmidt, H. Silva, V. Zampronio, and M. Prevedelli for careful reading.
  G.B. acknowledges support from the Austrian Science Fund (FWF) under Project No.
  M2641-N27. T.M. acknowledges CNPq for support through Bolsa de produtividade em
  Pesquisa No. 311079/2015-6. This work is supported by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) under Germany's Excellence Strategy No. EXC2181/1-390900948
  (the Heidelberg STRUCTURES Excellence Cluster). This work was supported by the Serrapilheira
  Institute (Grant No. Serra-1812-27802). We thank the High-Performance Computing
  Center (NPAD) at UFRN for providing computational resources.
article_number: '023301'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: A.
  full_name: Burchianti, A.
  last_name: Burchianti
- first_name: F.
  full_name: Minardi, F.
  last_name: Minardi
- first_name: T.
  full_name: Macrì, T.
  last_name: Macrì
citation:
  ama: Bighin G, Burchianti A, Minardi F, Macrì T. Impurity in a heteronuclear two-component
    Bose mixture. <i>Physical Review A</i>. 2022;106(2). doi:<a href="https://doi.org/10.1103/PhysRevA.106.023301">10.1103/PhysRevA.106.023301</a>
  apa: Bighin, G., Burchianti, A., Minardi, F., &#38; Macrì, T. (2022). Impurity in
    a heteronuclear two-component Bose mixture. <i>Physical Review A</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevA.106.023301">https://doi.org/10.1103/PhysRevA.106.023301</a>
  chicago: Bighin, Giacomo, A. Burchianti, F. Minardi, and T. Macrì. “Impurity in
    a Heteronuclear Two-Component Bose Mixture.” <i>Physical Review A</i>. American
    Physical Society, 2022. <a href="https://doi.org/10.1103/PhysRevA.106.023301">https://doi.org/10.1103/PhysRevA.106.023301</a>.
  ieee: G. Bighin, A. Burchianti, F. Minardi, and T. Macrì, “Impurity in a heteronuclear
    two-component Bose mixture,” <i>Physical Review A</i>, vol. 106, no. 2. American
    Physical Society, 2022.
  ista: Bighin G, Burchianti A, Minardi F, Macrì T. 2022. Impurity in a heteronuclear
    two-component Bose mixture. Physical Review A. 106(2), 023301.
  mla: Bighin, Giacomo, et al. “Impurity in a Heteronuclear Two-Component Bose Mixture.”
    <i>Physical Review A</i>, vol. 106, no. 2, 023301, American Physical Society,
    2022, doi:<a href="https://doi.org/10.1103/PhysRevA.106.023301">10.1103/PhysRevA.106.023301</a>.
  short: G. Bighin, A. Burchianti, F. Minardi, T. Macrì, Physical Review A 106 (2022).
date_created: 2022-08-28T22:02:00Z
date_published: 2022-08-04T00:00:00Z
date_updated: 2025-04-14T08:57:11Z
day: '04'
department:
- _id: MiLe
doi: 10.1103/PhysRevA.106.023301
external_id:
  arxiv:
  - '2109.07451'
  isi:
  - '000837953600006'
fulldoi: https://doi.org/10.1103/PhysRevA.106.023301
intvolume: '       106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2109.07451
month: '08'
oa: 1
oa_version: Preprint
project:
- _id: 26986C82-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02641
  name: A path-integral approach to composite impurities
publication: Physical Review A
publication_identifier:
  eissn:
  - 2469-9934
  issn:
  - 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impurity in a heteronuclear two-component Bose mixture
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2022'
...
---
_id: '11998'
abstract:
- lang: eng
  text: Recently it became possible to study highly excited rotational states of molecules
    in superfluid helium through nonadiabatic alignment experiments (Cherepanov et
    al 2021 Phys. Rev. A 104 L061303). This calls for theoretical approaches that
    go beyond explaining renormalized values of molecular spectroscopic constants,
    which suffices when only the lowest few rotational states are involved. As the
    first step in this direction, here we present a basic quantum mechanical model
    describing highly excited rotational states of molecules in superfluid helium
    nanodroplets. We show that a linear molecule immersed in a superfluid can be seen
    as an effective symmetric top, similar to the rotational structure of radicals,
    such as OH or NO, but with the angular momentum of the superfluid playing the
    role of the electronic angular momentum in free molecules. The simple theory sheds
    light onto what happens when the rotational angular momentum of the molecule increases
    beyond the lowest excited states accessible by infrared spectroscopy. In addition,
    the model allows to estimate the effective rotational and centrifugal distortion
    constants for a broad range of species and to explain the crossover between light
    and heavy molecules in superfluid 4He in terms of the many-body wavefunction structure.
    Some of the above mentioned insights can be acquired by analyzing a simple 2 ×
    2 matrix.
acknowledgement: IC acknowledges the support by the European Union's Horizon 2020
  research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
  No. 665385. GB acknowledges support from the Austrian Science Fund (FWF), under
  Project No. M2461-N27 and from the Deutsche Forschungsgemeinschaft (DFG, German
  Research Foundation) under Germany's Excellence Strategy EXC2181/1-390900948 (the
  Heidelberg STRUCTURES Excellence Cluster). ML acknowledges support by the Austrian
  Science Fund (FWF), under Project No. P29902-N27, and by the European Research Council
  (ERC) starting Grant No. 801770 (ANGULON). HS acknowledges support from the Independent
  Research Fund Denmark (Project No. 8021-00232B) and from the Villum Fonden through
  a Villum Investigator Grant No. 25886.
article_number: '075004'
article_processing_charge: Yes
article_type: original
author:
- first_name: Igor
  full_name: Cherepanov, Igor
  id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
  last_name: Cherepanov
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Constant A.
  full_name: Schouder, Constant A.
  last_name: Schouder
- first_name: Adam S.
  full_name: Chatterley, Adam S.
  last_name: Chatterley
- first_name: Henrik
  full_name: Stapelfeldt, Henrik
  last_name: Stapelfeldt
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Cherepanov I, Bighin G, Schouder CA, Chatterley AS, Stapelfeldt H, Lemeshko
    M. A simple model for high rotational excitations of molecules in a superfluid.
    <i>New Journal of Physics</i>. 2022;24(7). doi:<a href="https://doi.org/10.1088/1367-2630/ac8113">10.1088/1367-2630/ac8113</a>
  apa: Cherepanov, I., Bighin, G., Schouder, C. A., Chatterley, A. S., Stapelfeldt,
    H., &#38; Lemeshko, M. (2022). A simple model for high rotational excitations
    of molecules in a superfluid. <i>New Journal of Physics</i>. IOP Publishing. <a
    href="https://doi.org/10.1088/1367-2630/ac8113">https://doi.org/10.1088/1367-2630/ac8113</a>
  chicago: Cherepanov, Igor, Giacomo Bighin, Constant A. Schouder, Adam S. Chatterley,
    Henrik Stapelfeldt, and Mikhail Lemeshko. “A Simple Model for High Rotational
    Excitations of Molecules in a Superfluid.” <i>New Journal of Physics</i>. IOP
    Publishing, 2022. <a href="https://doi.org/10.1088/1367-2630/ac8113">https://doi.org/10.1088/1367-2630/ac8113</a>.
  ieee: I. Cherepanov, G. Bighin, C. A. Schouder, A. S. Chatterley, H. Stapelfeldt,
    and M. Lemeshko, “A simple model for high rotational excitations of molecules
    in a superfluid,” <i>New Journal of Physics</i>, vol. 24, no. 7. IOP Publishing,
    2022.
  ista: Cherepanov I, Bighin G, Schouder CA, Chatterley AS, Stapelfeldt H, Lemeshko
    M. 2022. A simple model for high rotational excitations of molecules in a superfluid.
    New Journal of Physics. 24(7), 075004.
  mla: Cherepanov, Igor, et al. “A Simple Model for High Rotational Excitations of
    Molecules in a Superfluid.” <i>New Journal of Physics</i>, vol. 24, no. 7, 075004,
    IOP Publishing, 2022, doi:<a href="https://doi.org/10.1088/1367-2630/ac8113">10.1088/1367-2630/ac8113</a>.
  short: I. Cherepanov, G. Bighin, C.A. Schouder, A.S. Chatterley, H. Stapelfeldt,
    M. Lemeshko, New Journal of Physics 24 (2022).
corr_author: '1'
date_created: 2022-08-28T22:02:01Z
date_published: 2022-08-11T00:00:00Z
date_updated: 2025-05-14T11:20:18Z
day: '11'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1088/1367-2630/ac8113
ec_funded: 1
external_id:
  isi:
  - '000839216900001'
file:
- access_level: open_access
  checksum: 10116a08d3489befc13dba2cc44490f1
  content_type: application/pdf
  creator: alisjak
  date_created: 2022-08-29T09:57:40Z
  date_updated: 2022-08-29T09:57:40Z
  file_id: '12005'
  file_name: 2022_NewJournalofPhysics_Cherepanov.pdf
  file_size: 1912882
  relation: main_file
  success: 1
file_date_updated: 2022-08-29T09:57:40Z
fulldoi: https://doi.org/10.1088/1367-2630/ac8113
has_accepted_license: '1'
intvolume: '        24'
isi: 1
issue: '7'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 26986C82-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02641
  name: A path-integral approach to composite impurities
publication: New Journal of Physics
publication_identifier:
  issn:
  - 1367-2630
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: A simple model for high rotational excitations of molecules in a superfluid
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2022'
...
---
_id: '12000'
abstract:
- lang: eng
  text: "We consider the quantitative problem of obtaining lower-bounds on the probability
    of termination of a given non-deterministic probabilistic program. Specifically,
    given a non-termination threshold p∈[0,1], we aim for certificates proving that
    the program terminates with probability at least 1−p. The basic idea of our approach
    is to find a terminating stochastic invariant, i.e. a subset SI of program states
    such that (i) the probability of the program ever leaving SI is no more than p,
    and (ii) almost-surely, the program either leaves SI or terminates.\r\n\r\nWhile
    stochastic invariants are already well-known, we provide the first proof that
    the idea above is not only sound, but also complete for quantitative termination
    analysis. We then introduce a novel sound and complete characterization of stochastic
    invariants that enables template-based approaches for easy synthesis of quantitative
    termination certificates, especially in affine or polynomial forms. Finally, by
    combining this idea with the existing martingale-based methods that are relatively
    complete for qualitative termination analysis, we obtain the first automated,
    sound, and relatively complete algorithm for quantitative termination analysis.
    Notably, our completeness guarantees for quantitative termination analysis are
    as strong as the best-known methods for the qualitative variant.\r\n\r\nOur prototype
    implementation demonstrates the effectiveness of our approach on various probabilistic
    programs. We also demonstrate that our algorithm certifies lower bounds on termination
    probability for probabilistic programs that are beyond the reach of previous methods."
acknowledgement: This research was partially supported by the ERC CoG 863818 (ForM-SMArt),
  the HKUST-Kaisa Joint Research Institute Project Grant HKJRI3A-055, the HKUST Startup
  Grant R9272 and the European Union’s Horizon 2020 research and innovation programme
  under the Marie Skłodowska-Curie Grant Agreement No. 665385.
alternative_title:
- LNCS
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Amir Kafshdar
  full_name: Goharshady, Amir Kafshdar
  id: 391365CE-F248-11E8-B48F-1D18A9856A87
  last_name: Goharshady
  orcid: 0000-0003-1702-6584
- first_name: Tobias
  full_name: Meggendorfer, Tobias
  id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
  last_name: Meggendorfer
  orcid: 0000-0002-1712-2165
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: 'Chatterjee K, Goharshady AK, Meggendorfer T, Zikelic D. Sound and complete
    certificates for auantitative termination analysis of probabilistic programs.
    In: <i>Proceedings of the 34th International Conference on Computer Aided Verification</i>.
    Vol 13371. Springer; 2022:55-78. doi:<a href="https://doi.org/10.1007/978-3-031-13185-1_4">10.1007/978-3-031-13185-1_4</a>'
  apa: 'Chatterjee, K., Goharshady, A. K., Meggendorfer, T., &#38; Zikelic, D. (2022).
    Sound and complete certificates for auantitative termination analysis of probabilistic
    programs. In <i>Proceedings of the 34th International Conference on Computer Aided
    Verification</i> (Vol. 13371, pp. 55–78). Haifa, Israel: Springer. <a href="https://doi.org/10.1007/978-3-031-13185-1_4">https://doi.org/10.1007/978-3-031-13185-1_4</a>'
  chicago: Chatterjee, Krishnendu, Amir Kafshdar Goharshady, Tobias Meggendorfer,
    and Dorde Zikelic. “Sound and Complete Certificates for Auantitative Termination
    Analysis of Probabilistic Programs.” In <i>Proceedings of the 34th International
    Conference on Computer Aided Verification</i>, 13371:55–78. Springer, 2022. <a
    href="https://doi.org/10.1007/978-3-031-13185-1_4">https://doi.org/10.1007/978-3-031-13185-1_4</a>.
  ieee: K. Chatterjee, A. K. Goharshady, T. Meggendorfer, and D. Zikelic, “Sound and complete
    certificates for auantitative termination analysis of probabilistic programs,”
    in <i>Proceedings of the 34th International Conference on Computer Aided Verification</i>,
    Haifa, Israel, 2022, vol. 13371, pp. 55–78.
  ista: 'Chatterjee K, Goharshady AK, Meggendorfer T, Zikelic D. 2022. Sound and complete
    certificates for auantitative termination analysis of probabilistic programs.
    Proceedings of the 34th International Conference on Computer Aided Verification.
    CAV: Computer Aided Verification, LNCS, vol. 13371, 55–78.'
  mla: Chatterjee, Krishnendu, et al. “Sound and Complete Certificates for Auantitative
    Termination Analysis of Probabilistic Programs.” <i>Proceedings of the 34th International
    Conference on Computer Aided Verification</i>, vol. 13371, Springer, 2022, pp.
    55–78, doi:<a href="https://doi.org/10.1007/978-3-031-13185-1_4">10.1007/978-3-031-13185-1_4</a>.
  short: K. Chatterjee, A.K. Goharshady, T. Meggendorfer, D. Zikelic, in:, Proceedings
    of the 34th International Conference on Computer Aided Verification, Springer,
    2022, pp. 55–78.
conference:
  end_date: 2022-08-10
  location: Haifa, Israel
  name: 'CAV: Computer Aided Verification'
  start_date: 2022-08-07
date_created: 2022-08-28T22:02:02Z
date_published: 2022-08-07T00:00:00Z
date_updated: 2026-04-07T13:27:55Z
day: '07'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/978-3-031-13185-1_4
ec_funded: 1
external_id:
  isi:
  - '000870304500004'
file:
- access_level: open_access
  checksum: 24e0f810ec52735a90ade95198bc641d
  content_type: application/pdf
  creator: alisjak
  date_created: 2022-08-29T09:17:01Z
  date_updated: 2022-08-29T09:17:01Z
  file_id: '12003'
  file_name: 2022_LNCS_Chatterjee.pdf
  file_size: 505094
  relation: main_file
  success: 1
file_date_updated: 2022-08-29T09:17:01Z
fulldoi: https://doi.org/10.1007/978-3-031-13185-1_4
has_accepted_license: '1'
intvolume: '     13371'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 55-78
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Proceedings of the 34th International Conference on Computer Aided Verification
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783031131844'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer
quality_controlled: '1'
related_material:
  record:
  - id: '14539'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Sound and complete certificates for auantitative termination analysis of probabilistic
  programs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13371
year: '2022'
...
---
_id: '12001'
abstract:
- lang: eng
  text: 'Sexual antagonism is a common hypothesis for driving the evolution of sex
    chromosomes, whereby recombination suppression is favored between sexually antagonistic
    loci and the sex-determining locus to maintain beneficial combinations of alleles.
    This results in the formation of a sex-determining region. Chromosomal inversions
    may contribute to recombination suppression but their precise role in sex chromosome
    evolution remains unclear. Because local adaptation is frequently facilitated
    through the suppression of recombination between adaptive loci by chromosomal
    inversions, there is potential for inversions that cover sex-determining regions
    to be involved in local adaptation as well, particularly if habitat variation
    creates environment-dependent sexual antagonism. With these processes in mind,
    we investigated sex determination in a well-studied example of local adaptation
    within a species: the intertidal snail, Littorina saxatilis. Using SNP data from
    a Swedish hybrid zone, we find novel evidence for a female-heterogametic sex determination
    system that is restricted to one ecotype. Our results suggest that four putative
    chromosomal inversions, two previously described and two newly discovered, span
    the putative sex chromosome pair. We determine their differing associations with
    sex, which suggest distinct strata of differing ages. The same inversions are
    found in the second ecotype but do not show any sex association. The striking
    disparity in inversion-sex associations between ecotypes that are connected by
    gene flow across a habitat transition that is just a few meters wide indicates
    a difference in selective regime that has produced a distinct barrier to the spread
    of the newly discovered sex-determining region between ecotypes. Such sex chromosome-environment
    interactions have not previously been uncovered in L. saxatilis and are known
    in few other organisms. A combination of both sex-specific selection and divergent
    natural selection is required to explain these highly unusual patterns.'
acknowledgement: We thank A. Wright and four anonymous reviewers for valuable comments
  on an earlier draft of this manuscript and all members of the Littorina group for
  helpful discussions. This work was supported by a European Research Council grant
  to RKB and by a Natural Environment Research Council studentship to KEH through
  the ACCE doctoral training program. KJ acknowledges support from the Swedish Science
  Research Council VR (Vetenskaprådet) (2017-03798). RF was supported by an FCT CEEC
  (Fundação para a Ciênca e a Tecnologia, Concurso Estímulo ao Emprego Científico)
  contract (2020.00275.CEECIND).
article_processing_charge: Yes
article_type: original
author:
- first_name: Katherine E.
  full_name: Hearn, Katherine E.
  last_name: Hearn
- first_name: Eva L.
  full_name: Koch, Eva L.
  last_name: Koch
- first_name: Sean
  full_name: Stankowski, Sean
  id: 43161670-5719-11EA-8025-FABC3DDC885E
  last_name: Stankowski
- first_name: Roger K.
  full_name: Butlin, Roger K.
  last_name: Butlin
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
citation:
  ama: Hearn KE, Koch EL, Stankowski S, et al. Differing associations between sex
    determination and sex-linked inversions in two ecotypes of Littorina saxatilis.
    <i>Evolution Letters</i>. 2022;6(5):358-374. doi:<a href="https://doi.org/10.1002/evl3.295">10.1002/evl3.295</a>
  apa: Hearn, K. E., Koch, E. L., Stankowski, S., Butlin, R. K., Faria, R., Johannesson,
    K., &#38; Westram, A. M. (2022). Differing associations between sex determination
    and sex-linked inversions in two ecotypes of Littorina saxatilis. <i>Evolution
    Letters</i>. Oxford University Press. <a href="https://doi.org/10.1002/evl3.295">https://doi.org/10.1002/evl3.295</a>
  chicago: Hearn, Katherine E., Eva L. Koch, Sean Stankowski, Roger K. Butlin, Rui
    Faria, Kerstin Johannesson, and Anja M Westram. “Differing Associations between
    Sex Determination and Sex-Linked Inversions in Two Ecotypes of Littorina Saxatilis.”
    <i>Evolution Letters</i>. Oxford University Press, 2022. <a href="https://doi.org/10.1002/evl3.295">https://doi.org/10.1002/evl3.295</a>.
  ieee: K. E. Hearn <i>et al.</i>, “Differing associations between sex determination
    and sex-linked inversions in two ecotypes of Littorina saxatilis,” <i>Evolution
    Letters</i>, vol. 6, no. 5. Oxford University Press, pp. 358–374, 2022.
  ista: Hearn KE, Koch EL, Stankowski S, Butlin RK, Faria R, Johannesson K, Westram
    AM. 2022. Differing associations between sex determination and sex-linked inversions
    in two ecotypes of Littorina saxatilis. Evolution Letters. 6(5), 358–374.
  mla: Hearn, Katherine E., et al. “Differing Associations between Sex Determination
    and Sex-Linked Inversions in Two Ecotypes of Littorina Saxatilis.” <i>Evolution
    Letters</i>, vol. 6, no. 5, Oxford University Press, 2022, pp. 358–74, doi:<a
    href="https://doi.org/10.1002/evl3.295">10.1002/evl3.295</a>.
  short: K.E. Hearn, E.L. Koch, S. Stankowski, R.K. Butlin, R. Faria, K. Johannesson,
    A.M. Westram, Evolution Letters 6 (2022) 358–374.
date_created: 2022-08-28T22:02:02Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2025-06-12T06:22:56Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/evl3.295
external_id:
  isi:
  - '000839621100001'
  pmid:
  - '36254259'
file:
- access_level: open_access
  checksum: 2dcd06186a11b7d1be4cddc6b189f8fb
  content_type: application/pdf
  creator: dernst
  date_created: 2023-02-27T07:17:42Z
  date_updated: 2023-02-27T07:17:42Z
  file_id: '12686'
  file_name: 2022_EvolutionLetters_Hearn.pdf
  file_size: 2368965
  relation: main_file
  success: 1
file_date_updated: 2023-02-27T07:17:42Z
fulldoi: https://doi.org/10.1002/evl3.295
has_accepted_license: '1'
intvolume: '         6'
isi: 1
issue: '5'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 358-374
pmid: 1
publication: Evolution Letters
publication_identifier:
  eissn:
  - 2056-3744
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differing associations between sex determination and sex-linked inversions
  in two ecotypes of Littorina saxatilis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2022'
...
---
_id: '12009'
abstract:
- lang: eng
  text: Changes in the short-term dynamics of excitatory synapses over development
    have been observed throughout cortex, but their purpose and consequences remain
    unclear. Here, we propose that developmental changes in synaptic dynamics buffer
    the effect of slow inhibitory long-term plasticity, allowing for continuously
    stable neural activity. Using computational modeling we demonstrate that early
    in development excitatory short-term depression quickly stabilises neural activity,
    even in the face of strong, unbalanced excitation. We introduce a model of the
    commonly observed developmental shift from depression to facilitation and show
    that neural activity remains stable throughout development, while inhibitory synaptic
    plasticity slowly balances excitation, consistent with experimental observations.
    Our model predicts changes in the input responses from phasic to phasic-and-tonic
    and more precise spike timings. We also observe a gradual emergence of short-lasting
    memory traces governed by short-term plasticity development. We conclude that
    the developmental depression-to-facilitation shift may control excitation-inhibition
    balance throughout development with important functional consequences.
acknowledgement: We would like to thank the Vogels Lab for feedback on an earlier
  version of this manuscript. D.W.J. was supported by a Marshall Scholarship and a
  Clarendon Scholarship. R.P.C. and T.P.V. were supported by a Wellcome Trust and
  Royal Society Sir Henry Dale Fellowship (WT 100000), a Wellcome Trust Senior Research
  Fellowship (214316/Z/18/Z), and an ERC Consolidator Grant (SYNAPSEEK).
article_number: '873'
article_processing_charge: No
article_type: original
author:
- first_name: David W.
  full_name: Jia, David W.
  last_name: Jia
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Rui Ponte
  full_name: Costa, Rui Ponte
  last_name: Costa
citation:
  ama: Jia DW, Vogels TP, Costa RP. Developmental depression-to-facilitation shift
    controls excitation-inhibition balance. <i>Communications biology</i>. 2022;5.
    doi:<a href="https://doi.org/10.1038/s42003-022-03801-2">10.1038/s42003-022-03801-2</a>
  apa: Jia, D. W., Vogels, T. P., &#38; Costa, R. P. (2022). Developmental depression-to-facilitation
    shift controls excitation-inhibition balance. <i>Communications Biology</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s42003-022-03801-2">https://doi.org/10.1038/s42003-022-03801-2</a>
  chicago: Jia, David W., Tim P Vogels, and Rui Ponte Costa. “Developmental Depression-to-Facilitation
    Shift Controls Excitation-Inhibition Balance.” <i>Communications Biology</i>.
    Springer Nature, 2022. <a href="https://doi.org/10.1038/s42003-022-03801-2">https://doi.org/10.1038/s42003-022-03801-2</a>.
  ieee: D. W. Jia, T. P. Vogels, and R. P. Costa, “Developmental depression-to-facilitation
    shift controls excitation-inhibition balance,” <i>Communications biology</i>,
    vol. 5. Springer Nature, 2022.
  ista: Jia DW, Vogels TP, Costa RP. 2022. Developmental depression-to-facilitation
    shift controls excitation-inhibition balance. Communications biology. 5, 873.
  mla: Jia, David W., et al. “Developmental Depression-to-Facilitation Shift Controls
    Excitation-Inhibition Balance.” <i>Communications Biology</i>, vol. 5, 873, Springer
    Nature, 2022, doi:<a href="https://doi.org/10.1038/s42003-022-03801-2">10.1038/s42003-022-03801-2</a>.
  short: D.W. Jia, T.P. Vogels, R.P. Costa, Communications Biology 5 (2022).
date_created: 2022-09-04T22:02:02Z
date_published: 2022-08-25T00:00:00Z
date_updated: 2025-04-14T09:44:14Z
day: '25'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s42003-022-03801-2
ec_funded: 1
external_id:
  isi:
  - '000844814800007'
file:
- access_level: open_access
  checksum: 3ec724c4f6d3440028c217305e32915f
  content_type: application/pdf
  creator: dernst
  date_created: 2022-09-05T08:55:11Z
  date_updated: 2022-09-05T08:55:11Z
  file_id: '12022'
  file_name: 2022_CommBiology_Jia.pdf
  file_size: 2491191
  relation: main_file
  success: 1
file_date_updated: 2022-09-05T08:55:11Z
fulldoi: https://doi.org/10.1038/s42003-022-03801-2
has_accepted_license: '1'
intvolume: '         5'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
  grant_number: 214316/Z/18/Z
  name: "Whatâ\x80\x99s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
    neuronal networks."
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
  call_identifier: H2020
  grant_number: '819603'
  name: Learning the shape of synaptic plasticity rules for neuronal architectures
    and function through machine learning.
publication: Communications biology
publication_identifier:
  eissn:
  - 2399-3642
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental depression-to-facilitation shift controls excitation-inhibition
  balance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2022'
...
---
_id: '12010'
abstract:
- lang: eng
  text: World models learn behaviors in a latent imagination space to enhance the
    sample-efficiency of deep reinforcement learning (RL) algorithms. While learning
    world models for high-dimensional observations (e.g., pixel inputs) has become
    practicable on standard RL benchmarks and some games, their effectiveness in real-world
    robotics applications has not been explored. In this paper, we investigate how
    such agents generalize to real-world autonomous vehicle control tasks, where advanced
    model-free deep RL algorithms fail. In particular, we set up a series of time-lap
    tasks for an F1TENTH racing robot, equipped with a high-dimensional LiDAR sensor,
    on a set of test tracks with a gradual increase in their complexity. In this continuous-control
    setting, we show that model-based agents capable of learning in imagination substantially
    outperform model-free agents with respect to performance, sample efficiency, successful
    task completion, and generalization. Moreover, we show that the generalization
    ability of model-based agents strongly depends on the choice of their observation
    model. We provide extensive empirical evidence for the effectiveness of world
    models provided with long enough memory horizons in sim2real tasks.
acknowledgement: L.B. was supported by the Doctoral College Resilient Embedded Systems.
  M.L. was supported in part by the ERC2020-AdG 101020093 and the Austrian Science
  Fund (FWF) under grant Z211-N23 (Wittgenstein Award). R.H. and D.R. were supported
  by The Boeing Company and the Office of Naval Research (ONR) Grant N00014-18-1-2830.
  R.G. was partially supported by the Horizon-2020 ECSEL Project grant No. 783163
  (iDev40) and A.B. by FFG Project ADEX.
article_processing_charge: No
arxiv: 1
author:
- first_name: Axel
  full_name: Brunnbauer, Axel
  last_name: Brunnbauer
- first_name: Luigi
  full_name: Berducci, Luigi
  last_name: Berducci
- first_name: Andreas
  full_name: Brandstatter, Andreas
  last_name: Brandstatter
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Ramin
  full_name: Hasani, Ramin
  last_name: Hasani
- first_name: Daniela
  full_name: Rus, Daniela
  last_name: Rus
- first_name: Radu
  full_name: Grosu, Radu
  last_name: Grosu
citation:
  ama: 'Brunnbauer A, Berducci L, Brandstatter A, et al. Latent imagination facilitates
    zero-shot transfer in autonomous racing. In: <i>2022 International Conference
    on Robotics and Automation</i>. IEEE; 2022:7513-7520. doi:<a href="https://doi.org/10.1109/ICRA46639.2022.9811650">10.1109/ICRA46639.2022.9811650</a>'
  apa: 'Brunnbauer, A., Berducci, L., Brandstatter, A., Lechner, M., Hasani, R., Rus,
    D., &#38; Grosu, R. (2022). Latent imagination facilitates zero-shot transfer
    in autonomous racing. In <i>2022 International Conference on Robotics and Automation</i>
    (pp. 7513–7520). Philadelphia, PA, United States: IEEE. <a href="https://doi.org/10.1109/ICRA46639.2022.9811650">https://doi.org/10.1109/ICRA46639.2022.9811650</a>'
  chicago: Brunnbauer, Axel, Luigi Berducci, Andreas Brandstatter, Mathias Lechner,
    Ramin Hasani, Daniela Rus, and Radu Grosu. “Latent Imagination Facilitates Zero-Shot
    Transfer in Autonomous Racing.” In <i>2022 International Conference on Robotics
    and Automation</i>, 7513–20. IEEE, 2022. <a href="https://doi.org/10.1109/ICRA46639.2022.9811650">https://doi.org/10.1109/ICRA46639.2022.9811650</a>.
  ieee: A. Brunnbauer <i>et al.</i>, “Latent imagination facilitates zero-shot transfer
    in autonomous racing,” in <i>2022 International Conference on Robotics and Automation</i>,
    Philadelphia, PA, United States, 2022, pp. 7513–7520.
  ista: 'Brunnbauer A, Berducci L, Brandstatter A, Lechner M, Hasani R, Rus D, Grosu
    R. 2022. Latent imagination facilitates zero-shot transfer in autonomous racing.
    2022 International Conference on Robotics and Automation. ICRA: International
    Conference on Robotics and Automation, 7513–7520.'
  mla: Brunnbauer, Axel, et al. “Latent Imagination Facilitates Zero-Shot Transfer
    in Autonomous Racing.” <i>2022 International Conference on Robotics and Automation</i>,
    IEEE, 2022, pp. 7513–20, doi:<a href="https://doi.org/10.1109/ICRA46639.2022.9811650">10.1109/ICRA46639.2022.9811650</a>.
  short: A. Brunnbauer, L. Berducci, A. Brandstatter, M. Lechner, R. Hasani, D. Rus,
    R. Grosu, in:, 2022 International Conference on Robotics and Automation, IEEE,
    2022, pp. 7513–7520.
conference:
  end_date: 2022-05-27
  location: Philadelphia, PA, United States
  name: 'ICRA: International Conference on Robotics and Automation'
  start_date: 2022-05-23
date_created: 2022-09-04T22:02:02Z
date_published: 2022-07-12T00:00:00Z
date_updated: 2025-09-10T09:39:53Z
day: '12'
department:
- _id: ToHe
doi: 10.1109/ICRA46639.2022.9811650
ec_funded: 1
external_id:
  arxiv:
  - '2103.04909'
  isi:
  - '000941277600124'
fulldoi: https://doi.org/10.1109/ICRA46639.2022.9811650
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2103.04909
month: '07'
oa: 1
oa_version: Preprint
page: 7513-7520
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
  call_identifier: H2020
  grant_number: '101020093'
  name: Vigilant Algorithmic Monitoring of Software
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
publication: 2022 International Conference on Robotics and Automation
publication_identifier:
  isbn:
  - '9781728196817'
  issn:
  - 1050-4729
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Latent imagination facilitates zero-shot transfer in autonomous racing
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2022'
...
---
_id: '12011'
abstract:
- lang: eng
  text: We characterize the capacity for the discrete-time arbitrarily varying channel
    with discrete inputs, outputs, and states when (a) the encoder and decoder do
    not share common randomness, (b) the input and state are subject to cost constraints,
    (c) the transition matrix of the channel is deterministic given the state, and
    (d) at each time step the adversary can only observe the current and past channel
    inputs when choosing the state at that time. The achievable strategy involves
    stochastic encoding together with list decoding and a disambiguation step. The
    converse uses a two-phase "babble-and-push" strategy where the adversary chooses
    the state randomly in the first phase, list decodes the output, and then chooses
    state inputs to symmetrize the channel in the second phase. These results generalize
    prior work on specific channels models (additive, erasure) to general discrete
    alphabets and models.
acknowledgement: The work of ADS and ML was supported in part by the US National Science
  Foundation under awards CCF-1909468 and CCF-1909451.
article_processing_charge: No
arxiv: 1
author:
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
- first_name: Sidharth
  full_name: Jaggi, Sidharth
  last_name: Jaggi
- first_name: Michael
  full_name: Langberg, Michael
  last_name: Langberg
- first_name: Anand D.
  full_name: Sarwate, Anand D.
  last_name: Sarwate
citation:
  ama: 'Zhang Y, Jaggi S, Langberg M, Sarwate AD. The capacity of causal adversarial
    channels. In: <i>2022 IEEE International Symposium on Information Theory</i>.
    Vol 2022. IEEE; 2022:2523-2528. doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834709">10.1109/ISIT50566.2022.9834709</a>'
  apa: 'Zhang, Y., Jaggi, S., Langberg, M., &#38; Sarwate, A. D. (2022). The capacity
    of causal adversarial channels. In <i>2022 IEEE International Symposium on Information
    Theory</i> (Vol. 2022, pp. 2523–2528). Espoo, Finland: IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834709">https://doi.org/10.1109/ISIT50566.2022.9834709</a>'
  chicago: Zhang, Yihan, Sidharth Jaggi, Michael Langberg, and Anand D. Sarwate. “The
    Capacity of Causal Adversarial Channels.” In <i>2022 IEEE International Symposium
    on Information Theory</i>, 2022:2523–28. IEEE, 2022. <a href="https://doi.org/10.1109/ISIT50566.2022.9834709">https://doi.org/10.1109/ISIT50566.2022.9834709</a>.
  ieee: Y. Zhang, S. Jaggi, M. Langberg, and A. D. Sarwate, “The capacity of causal
    adversarial channels,” in <i>2022 IEEE International Symposium on Information
    Theory</i>, Espoo, Finland, 2022, vol. 2022, pp. 2523–2528.
  ista: 'Zhang Y, Jaggi S, Langberg M, Sarwate AD. 2022. The capacity of causal adversarial
    channels. 2022 IEEE International Symposium on Information Theory. ISIT: International
    Symposium on Information Theory vol. 2022, 2523–2528.'
  mla: Zhang, Yihan, et al. “The Capacity of Causal Adversarial Channels.” <i>2022
    IEEE International Symposium on Information Theory</i>, vol. 2022, IEEE, 2022,
    pp. 2523–28, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834709">10.1109/ISIT50566.2022.9834709</a>.
  short: Y. Zhang, S. Jaggi, M. Langberg, A.D. Sarwate, in:, 2022 IEEE International
    Symposium on Information Theory, IEEE, 2022, pp. 2523–2528.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:03Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:40:42Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834709
external_id:
  arxiv:
  - '2205.06708'
  isi:
  - '001254261902114'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834709
intvolume: '      2022'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2205.06708'
month: '08'
oa: 1
oa_version: Preprint
page: 2523-2528
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: The capacity of causal adversarial channels
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12012'
abstract:
- lang: eng
  text: This paper is eligible for the Jack Keil Wolf ISIT Student Paper Award. We
    generalize a previous framework for designing utility-optimal differentially private
    (DP) mechanisms via graphs, where datasets are vertices in the graph and edges
    represent dataset neighborhood. The boundary set contains datasets where an individual’s
    response changes the binary-valued query compared to its neighbors. Previous work
    was limited to the homogeneous case where the privacy parameter ε across all datasets
    was the same and the mechanism at boundary datasets was identical. In our work,
    the mechanism can take different distributions at the boundary and the privacy
    parameter ε is a function of neighboring datasets, which recovers an earlier definition
    of personalized DP as special case. The problem is how to extend the mechanism,
    which is only defined at the boundary set, to other datasets in the graph in a
    computationally efficient and utility optimal manner. Using the concept of strongest
    induced DP condition we solve this problem efficiently in polynomial time (in
    the size of the graph).
article_processing_charge: No
arxiv: 1
author:
- first_name: Sahel
  full_name: Torkamani, Sahel
  id: 0503e7f8-2d05-11ed-aa17-db0640c720fc
  last_name: Torkamani
- first_name: Javad B.
  full_name: Ebrahimi, Javad B.
  last_name: Ebrahimi
- first_name: Parastoo
  full_name: Sadeghi, Parastoo
  last_name: Sadeghi
- first_name: Rafael G.L.
  full_name: D'Oliveira, Rafael G.L.
  last_name: D'Oliveira
- first_name: Muriel
  full_name: Médard, Muriel
  last_name: Médard
citation:
  ama: 'Torkamani S, Ebrahimi JB, Sadeghi P, D’Oliveira RGL, Médard M. Heterogeneous
    differential privacy via graphs. In: <i>2022 IEEE International Symposium on Information
    Theory</i>. Vol 2022. IEEE; 2022:1623-1628. doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834711">10.1109/ISIT50566.2022.9834711</a>'
  apa: 'Torkamani, S., Ebrahimi, J. B., Sadeghi, P., D’Oliveira, R. G. L., &#38; Médard,
    M. (2022). Heterogeneous differential privacy via graphs. In <i>2022 IEEE International
    Symposium on Information Theory</i> (Vol. 2022, pp. 1623–1628). Espoo, Finland:
    IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834711">https://doi.org/10.1109/ISIT50566.2022.9834711</a>'
  chicago: Torkamani, Sahel, Javad B. Ebrahimi, Parastoo Sadeghi, Rafael G.L. D’Oliveira,
    and Muriel Médard. “Heterogeneous Differential Privacy via Graphs.” In <i>2022
    IEEE International Symposium on Information Theory</i>, 2022:1623–28. IEEE, 2022.
    <a href="https://doi.org/10.1109/ISIT50566.2022.9834711">https://doi.org/10.1109/ISIT50566.2022.9834711</a>.
  ieee: S. Torkamani, J. B. Ebrahimi, P. Sadeghi, R. G. L. D’Oliveira, and M. Médard,
    “Heterogeneous differential privacy via graphs,” in <i>2022 IEEE International
    Symposium on Information Theory</i>, Espoo, Finland, 2022, vol. 2022, pp. 1623–1628.
  ista: 'Torkamani S, Ebrahimi JB, Sadeghi P, D’Oliveira RGL, Médard M. 2022. Heterogeneous
    differential privacy via graphs. 2022 IEEE International Symposium on Information
    Theory. ISIT: International Symposium on Information Theory vol. 2022, 1623–1628.'
  mla: Torkamani, Sahel, et al. “Heterogeneous Differential Privacy via Graphs.” <i>2022
    IEEE International Symposium on Information Theory</i>, vol. 2022, IEEE, 2022,
    pp. 1623–28, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834711">10.1109/ISIT50566.2022.9834711</a>.
  short: S. Torkamani, J.B. Ebrahimi, P. Sadeghi, R.G.L. D’Oliveira, M. Médard, in:,
    2022 IEEE International Symposium on Information Theory, IEEE, 2022, pp. 1623–1628.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:04Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:42:41Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834711
external_id:
  arxiv:
  - '2203.15429'
  isi:
  - '001254261901131'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834711
intvolume: '      2022'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2203.15429
month: '08'
oa: 1
oa_version: Preprint
page: 1623-1628
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Heterogeneous differential privacy via graphs
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12013'
abstract:
- lang: eng
  text: We consider the problem of communication over adversarial channels with feedback.
    Two parties comprising sender Alice and receiver Bob seek to communicate reliably.
    An adversary James observes Alice's channel transmission entirely and chooses,
    maliciously, its additive channel input or jamming state thereby corrupting Bob's
    observation. Bob can communicate over a one-way reverse link with Alice; we assume
    that transmissions over this feedback link cannot be corrupted by James. Our goal
    in this work is to study the optimum throughput or capacity over such channels
    with feedback. We first present results for the quadratically-constrained additive
    channel where communication is known to be impossible when the noise-to-signal
    (power) ratio (NSR) is at least 1. We present a novel achievability scheme to
    establish that positive rate communication is possible even when the NSR is as
    high as 8/9. We also present new converse upper bounds on the capacity of this
    channel under potentially stochastic encoders and decoders. We also study feedback
    communication over the more widely studied q-ary alphabet channel under additive
    noise. For the q -ary channel, where q > 2, it is well known that capacity is
    positive under full feedback if and only if the adversary can corrupt strictly
    less than half the transmitted symbols. We generalize this result and show that
    the same threshold holds for positive rate communication when the noiseless feedback
    may only be partial; our scheme employs a stochastic decoder. We extend this characterization,
    albeit partially, to fully deterministic schemes under partial noiseless feedback.
    We also present new converse upper bounds for q-ary channels under full feedback,
    where the encoder and/or decoder may privately randomize. Our converse results
    bring to the fore an interesting alternate expression for the well known converse
    bound for the q—ary channel under full feedback which, when specialized to the
    binary channel, also equals its known capacity.
article_processing_charge: No
author:
- first_name: Pranav
  full_name: Joshi, Pranav
  last_name: Joshi
- first_name: Amritakshya
  full_name: Purkayastha, Amritakshya
  last_name: Purkayastha
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
- first_name: Amitalok J.
  full_name: Budkuley, Amitalok J.
  last_name: Budkuley
- first_name: Sidharth
  full_name: Jaggi, Sidharth
  last_name: Jaggi
citation:
  ama: 'Joshi P, Purkayastha A, Zhang Y, Budkuley AJ, Jaggi S. On the capacity of
    additive AVCs with feedback. In: <i>2022 IEEE International Symposium on Information
    Theory</i>. Vol 2022. IEEE; 2022:504-509. doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834850">10.1109/ISIT50566.2022.9834850</a>'
  apa: 'Joshi, P., Purkayastha, A., Zhang, Y., Budkuley, A. J., &#38; Jaggi, S. (2022).
    On the capacity of additive AVCs with feedback. In <i>2022 IEEE International
    Symposium on Information Theory</i> (Vol. 2022, pp. 504–509). Espoo, Finland:
    IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834850">https://doi.org/10.1109/ISIT50566.2022.9834850</a>'
  chicago: Joshi, Pranav, Amritakshya Purkayastha, Yihan Zhang, Amitalok J. Budkuley,
    and Sidharth Jaggi. “On the Capacity of Additive AVCs with Feedback.” In <i>2022
    IEEE International Symposium on Information Theory</i>, 2022:504–9. IEEE, 2022.
    <a href="https://doi.org/10.1109/ISIT50566.2022.9834850">https://doi.org/10.1109/ISIT50566.2022.9834850</a>.
  ieee: P. Joshi, A. Purkayastha, Y. Zhang, A. J. Budkuley, and S. Jaggi, “On the
    capacity of additive AVCs with feedback,” in <i>2022 IEEE International Symposium
    on Information Theory</i>, Espoo, Finland, 2022, vol. 2022, pp. 504–509.
  ista: 'Joshi P, Purkayastha A, Zhang Y, Budkuley AJ, Jaggi S. 2022. On the capacity
    of additive AVCs with feedback. 2022 IEEE International Symposium on Information
    Theory. ISIT: International Symposium on Information Theory vol. 2022, 504–509.'
  mla: Joshi, Pranav, et al. “On the Capacity of Additive AVCs with Feedback.” <i>2022
    IEEE International Symposium on Information Theory</i>, vol. 2022, IEEE, 2022,
    pp. 504–09, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834850">10.1109/ISIT50566.2022.9834850</a>.
  short: P. Joshi, A. Purkayastha, Y. Zhang, A.J. Budkuley, S. Jaggi, in:, 2022 IEEE
    International Symposium on Information Theory, IEEE, 2022, pp. 504–509.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:04Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:42:04Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834850
external_id:
  isi:
  - '001254261900085'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834850
intvolume: '      2022'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 504-509
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the capacity of additive AVCs with feedback
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12014'
abstract:
- lang: eng
  text: We study the problem of high-dimensional multiple packing in Euclidean space.
    Multiple packing is a natural generalization of sphere packing and is defined
    as follows. Let N > 0 and L∈Z≥2. A multiple packing is a set C of points in Rn
    such that any point in Rn lies in the intersection of at most L – 1 balls of radius
    nN−−−√ around points in C. Given a well-known connection with coding theory, multiple
    packings can be viewed as the Euclidean analog of list-decodable codes, which
    are well-studied for finite fields. In this paper, we exactly pin down the asymptotic
    density of (expurgated) Poisson Point Processes under a stronger notion called
    average-radius multiple packing. To this end, we apply tools from high-dimensional
    geometry and large deviation theory. This gives rise to the best known lower bound
    on the largest multiple packing density. Our result corrects a mistake in a previous
    paper by Blinovsky [Bli05].
article_processing_charge: No
author:
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
- first_name: Shashank
  full_name: Vatedka, Shashank
  last_name: Vatedka
citation:
  ama: 'Zhang Y, Vatedka S. List-decodability of Poisson Point Processes. In: <i>2022
    IEEE International Symposium on Information Theory</i>. Vol 2022. IEEE; 2022:2559-2564.
    doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834512">10.1109/ISIT50566.2022.9834512</a>'
  apa: 'Zhang, Y., &#38; Vatedka, S. (2022). List-decodability of Poisson Point Processes.
    In <i>2022 IEEE International Symposium on Information Theory</i> (Vol. 2022,
    pp. 2559–2564). Espoo, Finland: IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834512">https://doi.org/10.1109/ISIT50566.2022.9834512</a>'
  chicago: Zhang, Yihan, and Shashank Vatedka. “List-Decodability of Poisson Point
    Processes.” In <i>2022 IEEE International Symposium on Information Theory</i>,
    2022:2559–64. IEEE, 2022. <a href="https://doi.org/10.1109/ISIT50566.2022.9834512">https://doi.org/10.1109/ISIT50566.2022.9834512</a>.
  ieee: Y. Zhang and S. Vatedka, “List-decodability of Poisson Point Processes,” in
    <i>2022 IEEE International Symposium on Information Theory</i>, Espoo, Finland,
    2022, vol. 2022, pp. 2559–2564.
  ista: 'Zhang Y, Vatedka S. 2022. List-decodability of Poisson Point Processes. 2022
    IEEE International Symposium on Information Theory. ISIT: International Symposium
    on Information Theory vol. 2022, 2559–2564.'
  mla: Zhang, Yihan, and Shashank Vatedka. “List-Decodability of Poisson Point Processes.”
    <i>2022 IEEE International Symposium on Information Theory</i>, vol. 2022, IEEE,
    2022, pp. 2559–64, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834512">10.1109/ISIT50566.2022.9834512</a>.
  short: Y. Zhang, S. Vatedka, in:, 2022 IEEE International Symposium on Information
    Theory, IEEE, 2022, pp. 2559–2564.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:04Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:41:24Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834512
external_id:
  isi:
  - '001254261902120'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834512
intvolume: '      2022'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 2559-2564
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: List-decodability of Poisson Point Processes
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12015'
abstract:
- lang: eng
  text: We study the problem of high-dimensional multiple packing in Euclidean space.
    Multiple packing is a natural generalization of sphere packing and is defined
    as follows. Let P, N > 0 and L∈Z≥2. A multiple packing is a set C of points in
    Bn(0–,nP−−−√) such that any point in ℝ n lies in the intersection of at most L
    – 1 balls of radius nN−−−√ around points in C. 1 In this paper, we derive two
    lower bounds on the largest possible density of a multiple packing. These bounds
    are obtained through a stronger notion called average-radius multiple packing.
    Specifically, we exactly pin down the asymptotics of (expurgated) Gaussian codes
    and (expurgated) spherical codes under average-radius multiple packing. To this
    end, we apply tools from high-dimensional geometry and large deviation theory.
    The bound for spherical codes matches the previous best known bound which was
    obtained for the standard (weaker) notion of multiple packing through a curious
    connection with error exponents [Bli99], [ZV21]. The bound for Gaussian codes
    suggests that they are strictly inferior to spherical codes.
article_processing_charge: No
author:
- first_name: Yihan
  full_name: Zhang, Yihan
  id: 2ce5da42-b2ea-11eb-bba5-9f264e9d002c
  last_name: Zhang
  orcid: 0000-0002-6465-6258
- first_name: Shashank
  full_name: Vatedka, Shashank
  last_name: Vatedka
citation:
  ama: 'Zhang Y, Vatedka S. Lower bounds for multiple packing. In: <i>2022 IEEE International
    Symposium on Information Theory</i>. Vol 2022. IEEE; 2022:3085-3090. doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834443">10.1109/ISIT50566.2022.9834443</a>'
  apa: 'Zhang, Y., &#38; Vatedka, S. (2022). Lower bounds for multiple packing. In
    <i>2022 IEEE International Symposium on Information Theory</i> (Vol. 2022, pp.
    3085–3090). Espoo, Finland: IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834443">https://doi.org/10.1109/ISIT50566.2022.9834443</a>'
  chicago: Zhang, Yihan, and Shashank Vatedka. “Lower Bounds for Multiple Packing.”
    In <i>2022 IEEE International Symposium on Information Theory</i>, 2022:3085–90.
    IEEE, 2022. <a href="https://doi.org/10.1109/ISIT50566.2022.9834443">https://doi.org/10.1109/ISIT50566.2022.9834443</a>.
  ieee: Y. Zhang and S. Vatedka, “Lower bounds for multiple packing,” in <i>2022 IEEE
    International Symposium on Information Theory</i>, Espoo, Finland, 2022, vol.
    2022, pp. 3085–3090.
  ista: 'Zhang Y, Vatedka S. 2022. Lower bounds for multiple packing. 2022 IEEE International
    Symposium on Information Theory. ISIT: International Symposium on Information
    Theory vol. 2022, 3085–3090.'
  mla: Zhang, Yihan, and Shashank Vatedka. “Lower Bounds for Multiple Packing.” <i>2022
    IEEE International Symposium on Information Theory</i>, vol. 2022, IEEE, 2022,
    pp. 3085–90, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834443">10.1109/ISIT50566.2022.9834443</a>.
  short: Y. Zhang, S. Vatedka, in:, 2022 IEEE International Symposium on Information
    Theory, IEEE, 2022, pp. 3085–3090.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:05Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:44:24Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834443
external_id:
  isi:
  - '001254261903042'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834443
intvolume: '      2022'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 3085-3090
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lower bounds for multiple packing
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12016'
abstract:
- lang: eng
  text: We consider the problem of coded distributed computing using polar codes.
    The average execution time of a coded computing system is related to the error
    probability for transmission over the binary erasure channel in recent work by
    Soleymani, Jamali and Mahdavifar, where the performance of binary linear codes
    is investigated. In this paper, we focus on polar codes and unveil a connection
    between the average execution time and the scaling exponent μ of the family of
    codes. In the finite-length characterization of polar codes, the scaling exponent
    is a key object capturing the speed of convergence to capacity. In particular,
    we show that (i) the gap between the normalized average execution time of polar
    codes and that of optimal MDS codes is O(n –1/μ ), and (ii) this upper bound can
    be improved to roughly O(n –1/2 ) by considering polar codes with large kernels.
    We conjecture that these bounds could be improved to O(n –2/μ ) and O(n –1 ),
    respectively, and provide a heuristic argument as well as numerical evidence supporting
    this view.
acknowledgement: D. Fathollahi and M. Mondelli were partially supported by the 2019
  Lopez-Loreta Prize. The authors thank Hamed Hassani and Hessam Mahdavifar for helpful
  discussions.
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorsa
  full_name: Fathollahi, Dorsa
  last_name: Fathollahi
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
citation:
  ama: 'Fathollahi D, Mondelli M. Polar coded computing: The role of the scaling exponent.
    In: <i>2022 IEEE International Symposium on Information Theory</i>. Vol 2022.
    IEEE; 2022:2154-2159. doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834712">10.1109/ISIT50566.2022.9834712</a>'
  apa: 'Fathollahi, D., &#38; Mondelli, M. (2022). Polar coded computing: The role
    of the scaling exponent. In <i>2022 IEEE International Symposium on Information
    Theory</i> (Vol. 2022, pp. 2154–2159). Espoo, Finland: IEEE. <a href="https://doi.org/10.1109/ISIT50566.2022.9834712">https://doi.org/10.1109/ISIT50566.2022.9834712</a>'
  chicago: 'Fathollahi, Dorsa, and Marco Mondelli. “Polar Coded Computing: The Role
    of the Scaling Exponent.” In <i>2022 IEEE International Symposium on Information
    Theory</i>, 2022:2154–59. IEEE, 2022. <a href="https://doi.org/10.1109/ISIT50566.2022.9834712">https://doi.org/10.1109/ISIT50566.2022.9834712</a>.'
  ieee: 'D. Fathollahi and M. Mondelli, “Polar coded computing: The role of the scaling
    exponent,” in <i>2022 IEEE International Symposium on Information Theory</i>,
    Espoo, Finland, 2022, vol. 2022, pp. 2154–2159.'
  ista: 'Fathollahi D, Mondelli M. 2022. Polar coded computing: The role of the scaling
    exponent. 2022 IEEE International Symposium on Information Theory. ISIT: International
    Symposium on Information Theory vol. 2022, 2154–2159.'
  mla: 'Fathollahi, Dorsa, and Marco Mondelli. “Polar Coded Computing: The Role of
    the Scaling Exponent.” <i>2022 IEEE International Symposium on Information Theory</i>,
    vol. 2022, IEEE, 2022, pp. 2154–59, doi:<a href="https://doi.org/10.1109/ISIT50566.2022.9834712">10.1109/ISIT50566.2022.9834712</a>.'
  short: D. Fathollahi, M. Mondelli, in:, 2022 IEEE International Symposium on Information
    Theory, IEEE, 2022, pp. 2154–2159.
conference:
  end_date: 2022-07-01
  location: Espoo, Finland
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2022-06-26
date_created: 2022-09-04T22:02:05Z
date_published: 2022-08-03T00:00:00Z
date_updated: 2025-09-10T09:43:32Z
day: '03'
department:
- _id: MaMo
doi: 10.1109/ISIT50566.2022.9834712
external_id:
  arxiv:
  - '2201.10082'
  isi:
  - '001254261902052'
fulldoi: https://doi.org/10.1109/ISIT50566.2022.9834712
intvolume: '      2022'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2201.10082
month: '08'
oa: 1
oa_version: Preprint
page: 2154-2159
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: 2022 IEEE International Symposium on Information Theory
publication_identifier:
  isbn:
  - '9781665421591'
  issn:
  - 2157-8095
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Polar coded computing: The role of the scaling exponent'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2022
year: '2022'
...
---
_id: '12051'
abstract:
- lang: eng
  text: Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is
    a major determinant of cellular growth, and dysregulation is observed in many
    cancer types. Here, we present the purification of human Pol I from cells carrying
    a genomic GFP fusion on the largest subunit allowing the structural and functional
    analysis of the enzyme across species. In contrast to yeast, human Pol I carries
    a single-subunit stalk, and in vitro transcription indicates a reduced proofreading
    activity. Determination of the human Pol I cryo-EM reconstruction in a close-to-native
    state rationalizes the effects of disease-associated mutations and uncovers an
    additional domain that is built into the sequence of Pol I subunit RPA1. This
    “dock II” domain resembles a truncated HMG box incapable of DNA binding which
    may serve as a downstream transcription factor–binding platform in metazoans.
    Biochemical analysis, in situ modelling, and ChIP data indicate that Topoisomerase
    2a can be recruited to Pol I via the domain and cooperates with the HMG box domain–containing
    factor UBF. These adaptations of the metazoan Pol I transcription system may allow
    efficient release of positive DNA supercoils accumulating downstream of the transcription
    bubble.
acknowledgement: "The authors especially thank Philip Gunkel for his contribution.
  We thank all\r\npast and present members of the Engel lab, Achim Griesenbeck, Colyn
  Crane-\r\nRobinson, Christophe Lotz, Marlene Vayssieres, Klaus Grasser, Herbert
  Tschochner, and Philipp Milkereit for help and discussion; Gerhard Lehmann and Nobert
  Eichner for IT support; Joost Zomerdijk for UBF-constructs, Volker Cordes for the
  Hela P2 cell line; Remco Sprangers for shared cell culture; Dina Grohmann and the
  Archaea Center for fermentation; and Thomas\r\nDresselhaus for access to fluorescence
  microscopes. This work was in part supported by the Emmy-Noether Programm (DFG grant
  no. EN 1204/1-1 to C Engel) of the German Research Council and Collaborative Research
  Center 960 (TP-A8 to C Engel)."
article_number: e202201568
article_processing_charge: No
article_type: original
author:
- first_name: Julia L
  full_name: Daiß, Julia L
  last_name: Daiß
- first_name: Michael
  full_name: Pilsl, Michael
  last_name: Pilsl
- first_name: Kristina
  full_name: Straub, Kristina
  last_name: Straub
- first_name: Andrea
  full_name: Bleckmann, Andrea
  last_name: Bleckmann
- first_name: Mona
  full_name: Höcherl, Mona
  last_name: Höcherl
- first_name: Florian B
  full_name: Heiss, Florian B
  last_name: Heiss
- first_name: Guillermo
  full_name: Abascal-Palacios, Guillermo
  last_name: Abascal-Palacios
- first_name: Ewan P
  full_name: Ramsay, Ewan P
  last_name: Ramsay
- first_name: Katarina
  full_name: Tluckova, Katarina
  id: 4AC7D980-F248-11E8-B48F-1D18A9856A87
  last_name: Tluckova
- first_name: Jean-Clement
  full_name: Mars, Jean-Clement
  last_name: Mars
- first_name: Torben
  full_name: Fürtges, Torben
  last_name: Fürtges
- first_name: Astrid
  full_name: Bruckmann, Astrid
  last_name: Bruckmann
- first_name: Till
  full_name: Rudack, Till
  last_name: Rudack
- first_name: Carrie A
  full_name: Bernecky, Carrie A
  id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
  last_name: Bernecky
  orcid: 0000-0003-0893-7036
- first_name: Valérie
  full_name: Lamour, Valérie
  last_name: Lamour
- first_name: Konstantin
  full_name: Panov, Konstantin
  last_name: Panov
- first_name: Alessandro
  full_name: Vannini, Alessandro
  last_name: Vannini
- first_name: Tom
  full_name: Moss, Tom
  last_name: Moss
- first_name: Christoph
  full_name: Engel, Christoph
  last_name: Engel
citation:
  ama: Daiß JL, Pilsl M, Straub K, et al. The human RNA polymerase I structure reveals
    an HMG-like docking domain specific to metazoans. <i>Life Science Alliance</i>.
    2022;5(11). doi:<a href="https://doi.org/10.26508/lsa.202201568">10.26508/lsa.202201568</a>
  apa: Daiß, J. L., Pilsl, M., Straub, K., Bleckmann, A., Höcherl, M., Heiss, F. B.,
    … Engel, C. (2022). The human RNA polymerase I structure reveals an HMG-like docking
    domain specific to metazoans. <i>Life Science Alliance</i>. Life Science Alliance.
    <a href="https://doi.org/10.26508/lsa.202201568">https://doi.org/10.26508/lsa.202201568</a>
  chicago: Daiß, Julia L, Michael Pilsl, Kristina Straub, Andrea Bleckmann, Mona Höcherl,
    Florian B Heiss, Guillermo Abascal-Palacios, et al. “The Human RNA Polymerase
    I Structure Reveals an HMG-like Docking Domain Specific to Metazoans.” <i>Life
    Science Alliance</i>. Life Science Alliance, 2022. <a href="https://doi.org/10.26508/lsa.202201568">https://doi.org/10.26508/lsa.202201568</a>.
  ieee: J. L. Daiß <i>et al.</i>, “The human RNA polymerase I structure reveals an
    HMG-like docking domain specific to metazoans,” <i>Life Science Alliance</i>,
    vol. 5, no. 11. Life Science Alliance, 2022.
  ista: Daiß JL, Pilsl M, Straub K, Bleckmann A, Höcherl M, Heiss FB, Abascal-Palacios
    G, Ramsay EP, Tluckova K, Mars J-C, Fürtges T, Bruckmann A, Rudack T, Bernecky
    C, Lamour V, Panov K, Vannini A, Moss T, Engel C. 2022. The human RNA polymerase
    I structure reveals an HMG-like docking domain specific to metazoans. Life Science
    Alliance. 5(11), e202201568.
  mla: Daiß, Julia L., et al. “The Human RNA Polymerase I Structure Reveals an HMG-like
    Docking Domain Specific to Metazoans.” <i>Life Science Alliance</i>, vol. 5, no.
    11, e202201568, Life Science Alliance, 2022, doi:<a href="https://doi.org/10.26508/lsa.202201568">10.26508/lsa.202201568</a>.
  short: J.L. Daiß, M. Pilsl, K. Straub, A. Bleckmann, M. Höcherl, F.B. Heiss, G.
    Abascal-Palacios, E.P. Ramsay, K. Tluckova, J.-C. Mars, T. Fürtges, A. Bruckmann,
    T. Rudack, C. Bernecky, V. Lamour, K. Panov, A. Vannini, T. Moss, C. Engel, Life
    Science Alliance 5 (2022).
date_created: 2022-09-06T18:45:23Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2024-10-21T06:01:48Z
day: '01'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.26508/lsa.202201568
external_id:
  isi:
  - '000972702600001'
file:
- access_level: open_access
  checksum: 4201d876a3e5e8b65e319d03300014ad
  content_type: application/pdf
  creator: dernst
  date_created: 2022-09-08T06:41:14Z
  date_updated: 2022-09-08T06:41:14Z
  file_id: '12062'
  file_name: 2022_LifeScienceAlliance_Daiss.pdf
  file_size: 3183129
  relation: main_file
  success: 1
file_date_updated: 2022-09-08T06:41:14Z
fulldoi: https://doi.org/10.26508/lsa.202201568
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '11'
keyword:
- Health
- Toxicology and Mutagenesis
- Plant Science
- Biochemistry
- Genetics and Molecular Biology (miscellaneous)
- Ecology
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Life Science Alliance
publication_identifier:
  issn:
  - 2575-1077
publication_status: published
publisher: Life Science Alliance
quality_controlled: '1'
scopus_import: '1'
status: public
title: The human RNA polymerase I structure reveals an HMG-like docking domain specific
  to metazoans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2022'
...
---
_id: '12052'
abstract:
- lang: eng
  text: Directionality in the intercellular transport of the plant hormone auxin is
    determined by polar plasma membrane localization of PIN-FORMED (PIN) auxin transport
    proteins. However, apart from PIN phosphorylation at conserved motifs, no further
    determinants explicitly controlling polar PIN sorting decisions have been identified.
    Here we present Arabidopsis WAVY GROWTH 3 (WAV3) and closely related RING-finger
    E3 ubiquitin ligases, whose loss-of-function mutants show a striking apical-to-basal
    polarity switch in PIN2 localization in root meristem cells. WAV3 E3 ligases function
    as essential determinants for PIN polarity, acting independently from PINOID/WAG-dependent
    PIN phosphorylation. They antagonize ectopic deposition of de novo synthesized
    PIN proteins already immediately following completion of cell division, presumably
    via preventing PIN sorting into basal, ARF GEF-mediated trafficking. Our findings
    reveal an involvement of E3 ligases in the selective targeting of apically localized
    PINs in higher plants.
acknowledgement: We would like to thank Tatsuo Sakai, Marcus Heisler, Toru Fujiwara,
  Lucia Strader, Christian Hardtke, Malcolm Bennett, Claus Schwechheimer, Gerd Jürgens
  and Remko Offringa for sharing published materials and Alba Grau Gimeno for support.
  We are greatly indebted to Bert de Rybel for supporting N.K. and M.G. to work on
  the final stages of manuscript preparation as postdocs in his laboratory. A full-length
  SOR1 cDNA clone (J090099M14) was obtained from the National Agriculture and Food
  Research Organization (NARO, Japan). Support by the Multiscale Imaging Core Facility
  at the BOKU is greatly acknowledged. This work has been supported by grants from
  the Austrian Science Fund (FWF P25931-B16; P31493-B25 to Christian Luschnig; I3630-B25
  to Jiří Friml; P30850-B32 to Barbara Korbei) and from the Swiss National Funds (31003A-165877/1
  to Markus Geisler) and the European Union’s Horizon 2020 research and innovation
  program (Marie Skłodowska-Curie grant agreement No 885979 to Matouš Glanc).
article_number: '5147'
article_processing_charge: No
article_type: original
author:
- first_name: N
  full_name: Konstantinova, N
  last_name: Konstantinova
- first_name: Lukas
  full_name: Hörmayer, Lukas
  id: 2EEE7A2A-F248-11E8-B48F-1D18A9856A87
  last_name: Hörmayer
  orcid: 0000-0001-8295-2926
- first_name: Matous
  full_name: Glanc, Matous
  id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
  last_name: Glanc
  orcid: 0000-0003-0619-7783
- first_name: R
  full_name: Keshkeih, R
  last_name: Keshkeih
- first_name: Shutang
  full_name: Tan, Shutang
  id: 2DE75584-F248-11E8-B48F-1D18A9856A87
  last_name: Tan
  orcid: 0000-0002-0471-8285
- first_name: M
  full_name: Di Donato, M
  last_name: Di Donato
- first_name: K
  full_name: Retzer, K
  last_name: Retzer
- first_name: J
  full_name: Moulinier-Anzola, J
  last_name: Moulinier-Anzola
- first_name: M
  full_name: Schwihla, M
  last_name: Schwihla
- first_name: B
  full_name: Korbei, B
  last_name: Korbei
- first_name: M
  full_name: Geisler, M
  last_name: Geisler
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: C
  full_name: Luschnig, C
  last_name: Luschnig
citation:
  ama: Konstantinova N, Hörmayer L, Glanc M, et al. WAVY GROWTH Arabidopsis E3 ubiquitin
    ligases affect apical PIN sorting decisions. <i>Nature Communications</i>. 2022;13.
    doi:<a href="https://doi.org/10.1038/s41467-022-32888-8">10.1038/s41467-022-32888-8</a>
  apa: Konstantinova, N., Hörmayer, L., Glanc, M., Keshkeih, R., Tan, S., Di Donato,
    M., … Luschnig, C. (2022). WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect
    apical PIN sorting decisions. <i>Nature Communications</i>. Springer Nature. <a
    href="https://doi.org/10.1038/s41467-022-32888-8">https://doi.org/10.1038/s41467-022-32888-8</a>
  chicago: Konstantinova, N, Lukas Hörmayer, Matous Glanc, R Keshkeih, Shutang Tan,
    M Di Donato, K Retzer, et al. “WAVY GROWTH Arabidopsis E3 Ubiquitin Ligases Affect
    Apical PIN Sorting Decisions.” <i>Nature Communications</i>. Springer Nature,
    2022. <a href="https://doi.org/10.1038/s41467-022-32888-8">https://doi.org/10.1038/s41467-022-32888-8</a>.
  ieee: N. Konstantinova <i>et al.</i>, “WAVY GROWTH Arabidopsis E3 ubiquitin ligases
    affect apical PIN sorting decisions,” <i>Nature Communications</i>, vol. 13. Springer
    Nature, 2022.
  ista: Konstantinova N, Hörmayer L, Glanc M, Keshkeih R, Tan S, Di Donato M, Retzer
    K, Moulinier-Anzola J, Schwihla M, Korbei B, Geisler M, Friml J, Luschnig C. 2022.
    WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions.
    Nature Communications. 13, 5147.
  mla: Konstantinova, N., et al. “WAVY GROWTH Arabidopsis E3 Ubiquitin Ligases Affect
    Apical PIN Sorting Decisions.” <i>Nature Communications</i>, vol. 13, 5147, Springer
    Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-32888-8">10.1038/s41467-022-32888-8</a>.
  short: N. Konstantinova, L. Hörmayer, M. Glanc, R. Keshkeih, S. Tan, M. Di Donato,
    K. Retzer, J. Moulinier-Anzola, M. Schwihla, B. Korbei, M. Geisler, J. Friml,
    C. Luschnig, Nature Communications 13 (2022).
date_created: 2022-09-07T14:19:26Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2025-04-15T07:32:09Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41467-022-32888-8
external_id:
  isi:
  - '000848744900004'
  pmid:
  - '36050482'
file:
- access_level: open_access
  checksum: 43336758c89cd6c045839089af070afe
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  creator: dernst
  date_created: 2022-09-08T07:46:16Z
  date_updated: 2022-09-08T07:46:16Z
  file_id: '12063'
  file_name: 2022_NatureCommunications_Konstantinova.pdf
  file_size: 6678579
  relation: main_file
  success: 1
file_date_updated: 2022-09-08T07:46:16Z
fulldoi: https://doi.org/10.1038/s41467-022-32888-8
has_accepted_license: '1'
intvolume: '        13'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03630
  name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/s41467-022-33198-9
scopus_import: '1'
status: public
title: WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '12053'
abstract:
- lang: eng
  text: Strigolactones (SLs) are a class of phytohormones that regulate plant shoot
    branching and adventitious root development. However, little is known regarding
    the role of SLs in controlling the behavior of the smallest unit of the organism,
    the single cell. Here, taking advantage of a classic single-cell model offered
    by the cotton (Gossypium hirsutum) fiber cell, we show that SLs, whose biosynthesis
    is fine-tuned by gibberellins (GAs), positively regulate cell elongation and cell
    wall thickness by promoting the biosynthesis of very-long-chain fatty acids (VLCFAs)
    and cellulose, respectively. Furthermore, we identified two layers of transcription
    factors (TFs) involved in the hierarchical regulation of this GA-SL crosstalk.
    The top-layer TF GROWTH-REGULATING FACTOR 4 (GhGRF4) directly activates expression
    of the SL biosynthetic gene DWARF27 (D27) to increase SL accumulation in fiber
    cells and GAs induce GhGRF4 expression. SLs induce the expression of four second-layer
    TF genes (GhNAC100-2, GhBLH51, GhGT2, and GhB9SHZ1), which transmit SL signals
    downstream to two ketoacyl-CoA synthase genes (KCS) and three cellulose synthase
    (CesA) genes by directly activating their transcription. Finally, the KCS and
    CesA enzymes catalyze the biosynthesis of very long chain fatty acids and cellulose,
    respectively, to regulate development of high-grade cotton fibers. In addition
    to providing a theoretical basis for cotton fiber improvement, our results shed
    light on SL signaling in plant development at the single-cell level.
acknowledgement: This work was supported by the National Natural Science Foundation
  of China (32070549), Shaanxi Youth Entrusted Talent Program (20190205), Fundamental
  Research Funds for the Central Universities (GK202002005 and GK202201017), Young
  Elite Scientists Sponsorship Program by China Association for Science and Technology
  (CAST) (2019-2021QNRC001), State Key Laboratory of Cotton Biology Open Fund (CB2020A12
  and CB2021A21) and FWF Stand-alone Project (P29988).
article_processing_charge: No
article_type: original
author:
- first_name: Z
  full_name: Tian, Z
  last_name: Tian
- first_name: Yuzhou
  full_name: Zhang, Yuzhou
  id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
  last_name: Zhang
  orcid: 0000-0003-2627-6956
- first_name: L
  full_name: Zhu, L
  last_name: Zhu
- first_name: B
  full_name: Jiang, B
  last_name: Jiang
- first_name: H
  full_name: Wang, H
  last_name: Wang
- first_name: R
  full_name: Gao, R
  last_name: Gao
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: G
  full_name: Xiao, G
  last_name: Xiao
citation:
  ama: Tian Z, Zhang Y, Zhu L, et al. Strigolactones act downstream of gibberellins
    to regulate fiber cell elongation and cell wall thickness in cotton (Gossypium
    hirsutum). <i>The Plant Cell</i>. 2022;34(12):4816-4839. doi:<a href="https://doi.org/10.1093/plcell/koac270">10.1093/plcell/koac270</a>
  apa: Tian, Z., Zhang, Y., Zhu, L., Jiang, B., Wang, H., Gao, R., … Xiao, G. (2022).
    Strigolactones act downstream of gibberellins to regulate fiber cell elongation
    and cell wall thickness in cotton (Gossypium hirsutum). <i>The Plant Cell</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/plcell/koac270">https://doi.org/10.1093/plcell/koac270</a>
  chicago: Tian, Z, Yuzhou Zhang, L Zhu, B Jiang, H Wang, R Gao, Jiří Friml, and G
    Xiao. “Strigolactones Act Downstream of Gibberellins to Regulate Fiber Cell Elongation
    and Cell Wall Thickness in Cotton (Gossypium Hirsutum).” <i>The Plant Cell</i>.
    Oxford University Press, 2022. <a href="https://doi.org/10.1093/plcell/koac270">https://doi.org/10.1093/plcell/koac270</a>.
  ieee: Z. Tian <i>et al.</i>, “Strigolactones act downstream of gibberellins to regulate
    fiber cell elongation and cell wall thickness in cotton (Gossypium hirsutum),”
    <i>The Plant Cell</i>, vol. 34, no. 12. Oxford University Press, pp. 4816–4839,
    2022.
  ista: Tian Z, Zhang Y, Zhu L, Jiang B, Wang H, Gao R, Friml J, Xiao G. 2022. Strigolactones
    act downstream of gibberellins to regulate fiber cell elongation and cell wall
    thickness in cotton (Gossypium hirsutum). The Plant Cell. 34(12), 4816–4839.
  mla: Tian, Z., et al. “Strigolactones Act Downstream of Gibberellins to Regulate
    Fiber Cell Elongation and Cell Wall Thickness in Cotton (Gossypium Hirsutum).”
    <i>The Plant Cell</i>, vol. 34, no. 12, Oxford University Press, 2022, pp. 4816–39,
    doi:<a href="https://doi.org/10.1093/plcell/koac270">10.1093/plcell/koac270</a>.
  short: Z. Tian, Y. Zhang, L. Zhu, B. Jiang, H. Wang, R. Gao, J. Friml, G. Xiao,
    The Plant Cell 34 (2022) 4816–4839.
date_created: 2022-09-07T14:19:39Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2025-04-15T08:12:07Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1093/plcell/koac270
external_id:
  isi:
  - '000852753000001'
  pmid:
  - '36040191'
file:
- access_level: open_access
  checksum: 1c606d9545f29dfca15235f69ad27b58
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T08:29:12Z
  date_updated: 2023-01-20T08:29:12Z
  file_id: '12318'
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  relation: main_file
  success: 1
file_date_updated: 2023-01-20T08:29:12Z
fulldoi: https://doi.org/10.1093/plcell/koac270
has_accepted_license: '1'
intvolume: '        34'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 4816-4839
pmid: 1
project:
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29988
  name: RNA-directed DNA methylation in plant development
publication: The Plant Cell
publication_identifier:
  eissn:
  - 1532-298X
  issn:
  - 1040-4651
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1093/plcell/koac342
scopus_import: '1'
status: public
title: Strigolactones act downstream of gibberellins to regulate fiber cell elongation
  and cell wall thickness in cotton (Gossypium hirsutum)
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 34
year: '2022'
...
---
_id: '12054'
abstract:
- lang: eng
  text: 'Polar auxin transport is unique to plants and coordinates their growth and
    development1,2. The PIN-FORMED (PIN) auxin transporters exhibit highly asymmetrical
    localizations at the plasma membrane and drive polar auxin transport3,4; however,
    their structures and transport mechanisms remain largely unknown. Here, we report
    three inward-facing conformation structures of Arabidopsis thaliana PIN1: the
    apo state, bound to the natural auxin indole-3-acetic acid (IAA), and in complex
    with the polar auxin transport inhibitor N-1-naphthylphthalamic acid (NPA). The
    transmembrane domain of PIN1 shares a conserved NhaA fold5. In the substrate-bound
    structure, IAA is coordinated by both hydrophobic stacking and hydrogen bonding.
    NPA competes with IAA for the same site at the intracellular pocket, but with
    a much higher affinity. These findings inform our understanding of the substrate
    recognition and transport mechanisms of PINs and set up a framework for future
    research on directional auxin transport, one of the most crucial processes underlying
    plant development.'
acknowledgement: We thank the Cryo-EM Center of the University of Science and Technology
  of China (USTC) and the Center for Biological Imaging (CBI), Institute of Biophysics,
  Chinese Academy of Science, for the EM facility support; we thank B. Zhu, X. Huang
  and all the other staff members for their technical support on cryo-EM data collection.
  We thank J. Ren for his technical support with the transport assays and M. Seeger
  for providing the sybody libraries. This work was supported by the Strategic Priority
  Research Program of Chinese Academy of Sciences (XDB 37020204 to D.L. and XDB37020103
  to Linfeng Sun), National Natural Science Foundation of China (82151215 and 31870726
  to D.L., 31900885 to X.L., and 31870732 to Linfeng Sun), Natural Science Foundation
  of Anhui Province (2008085MC90 to X.L. and 2008085J15 to Linfeng Sun), the Fundamental
  Research Funds for the Central Universities (WK9100000031 to Linfeng Sun), and the
  USTC Research Funds of the Double First-Class Initiative (YD9100002004 to Linfeng
  Sun). Linfeng Sun is supported by an Outstanding Young Scholar Award from the Qiu
  Shi Science and Technologies Foundation, and a Young Scholar Award from the Cyrus
  Tang Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Z
  full_name: Yang, Z
  last_name: Yang
- first_name: J
  full_name: Xia, J
  last_name: Xia
- first_name: J
  full_name: Hong, J
  last_name: Hong
- first_name: C
  full_name: Zhang, C
  last_name: Zhang
- first_name: H
  full_name: Wei, H
  last_name: Wei
- first_name: W
  full_name: Ying, W
  last_name: Ying
- first_name: C
  full_name: Sun, C
  last_name: Sun
- first_name: L
  full_name: Sun, L
  last_name: Sun
- first_name: Y
  full_name: Mao, Y
  last_name: Mao
- first_name: Y
  full_name: Gao, Y
  last_name: Gao
- first_name: S
  full_name: Tan, S
  last_name: Tan
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: D
  full_name: Li, D
  last_name: Li
- first_name: X
  full_name: Liu, X
  last_name: Liu
- first_name: L
  full_name: Sun, L
  last_name: Sun
citation:
  ama: Yang Z, Xia J, Hong J, et al. Structural insights into auxin recognition and
    efflux by Arabidopsis PIN1. <i>Nature</i>. 2022;609(7927):611-615. doi:<a href="https://doi.org/10.1038/s41586-022-05143-9">10.1038/s41586-022-05143-9</a>
  apa: Yang, Z., Xia, J., Hong, J., Zhang, C., Wei, H., Ying, W., … Sun, L. (2022).
    Structural insights into auxin recognition and efflux by Arabidopsis PIN1. <i>Nature</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41586-022-05143-9">https://doi.org/10.1038/s41586-022-05143-9</a>
  chicago: Yang, Z, J Xia, J Hong, C Zhang, H Wei, W Ying, C Sun, et al. “Structural
    Insights into Auxin Recognition and Efflux by Arabidopsis PIN1.” <i>Nature</i>.
    Springer Nature, 2022. <a href="https://doi.org/10.1038/s41586-022-05143-9">https://doi.org/10.1038/s41586-022-05143-9</a>.
  ieee: Z. Yang <i>et al.</i>, “Structural insights into auxin recognition and efflux
    by Arabidopsis PIN1,” <i>Nature</i>, vol. 609, no. 7927. Springer Nature, pp.
    611–615, 2022.
  ista: Yang Z, Xia J, Hong J, Zhang C, Wei H, Ying W, Sun C, Sun L, Mao Y, Gao Y,
    Tan S, Friml J, Li D, Liu X, Sun L. 2022. Structural insights into auxin recognition
    and efflux by Arabidopsis PIN1. Nature. 609(7927), 611–615.
  mla: Yang, Z., et al. “Structural Insights into Auxin Recognition and Efflux by
    Arabidopsis PIN1.” <i>Nature</i>, vol. 609, no. 7927, Springer Nature, 2022, pp.
    611–15, doi:<a href="https://doi.org/10.1038/s41586-022-05143-9">10.1038/s41586-022-05143-9</a>.
  short: Z. Yang, J. Xia, J. Hong, C. Zhang, H. Wei, W. Ying, C. Sun, L. Sun, Y. Mao,
    Y. Gao, S. Tan, J. Friml, D. Li, X. Liu, L. Sun, Nature 609 (2022) 611–615.
date_created: 2022-09-07T14:19:52Z
date_published: 2022-08-02T00:00:00Z
date_updated: 2023-08-03T13:41:44Z
day: '02'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41586-022-05143-9
external_id:
  isi:
  - '000848082900002'
  pmid:
  - '35917925'
file:
- access_level: open_access
  checksum: 3136a585f8e1c7e73b5e1418b3d01898
  content_type: application/pdf
  creator: dernst
  date_created: 2022-09-08T08:02:54Z
  date_updated: 2022-09-08T08:02:54Z
  file_id: '12064'
  file_name: 2022_Nature_Yang.pdf
  file_size: 32344580
  relation: main_file
  success: 1
file_date_updated: 2022-09-08T08:02:54Z
fulldoi: https://doi.org/10.1038/s41586-022-05143-9
has_accepted_license: '1'
intvolume: '       609'
isi: 1
issue: '7927'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 611-615
pmid: 1
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural insights into auxin recognition and efflux by Arabidopsis PIN1
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2022'
...
