---
_id: '10270'
abstract:
- lang: eng
text: Plants develop new organs to adjust their bodies to dynamic changes in the
environment. How independent organs achieve anisotropic shapes and polarities
is poorly understood. To address this question, we constructed a mechano-biochemical
model for Arabidopsis root meristem growth that integrates biologically plausible
principles. Computer model simulations demonstrate how differential growth of
neighboring tissues results in the initial symmetry-breaking leading to anisotropic
root growth. Furthermore, the root growth feeds back on a polar transport network
of the growth regulator auxin. Model, predictions are in close agreement with
in vivo patterns of anisotropic growth, auxin distribution, and cell polarity,
as well as several root phenotypes caused by chemical, mechanical, or genetic
perturbations. Our study demonstrates that the combination of tissue mechanics
and polar auxin transport organizes anisotropic root growth and cell polarities
during organ outgrowth. Therefore, a mobile auxin signal transported through immobile
cells drives polarity and growth mechanics to coordinate complex organ development.
acknowledgement: 'e are grateful Richard Smith, Anne-Lise Routier, Crisanto Gutierrez
and Juergen Kleine-Vehn for providing critical comments on the manuscript. Funding:
This work was supported by the Programa de Atraccion de Talento 2017 (Comunidad
de Madrid, 2017-T1/BIO-5654 to KW), Severo Ochoa (SO) Programme for Centres of Excellence
in R&D from the Agencia Estatal de Investigacion of Spain (grant SEV-2016–0672 (2017–2021)
to KW via the CBGP). In the frame of SEV-2016–0672 funding MM is supported with
a postdoctoral contract. KW was supported by Programa Estatal de Generacion del
Conocimiento y Fortalecimiento Cientıfico y Tecnologico del Sistema de I + D + I
2019 (PGC2018-093387-A-I00) from MICIU (to KW). MG is recipient of an IST Interdisciplinary
Project (IC1022IPC03).'
article_number: '72132'
article_processing_charge: Yes
article_type: original
author:
- first_name: Marco
full_name: Marconi, Marco
last_name: Marconi
- first_name: Marçal
full_name: Gallemi, Marçal
id: 460C6802-F248-11E8-B48F-1D18A9856A87
last_name: Gallemi
orcid: 0000-0003-4675-6893
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Krzysztof
full_name: Wabnik, Krzysztof
last_name: Wabnik
citation:
ama: Marconi M, Gallemi M, Benková E, Wabnik K. A coupled mechano-biochemical model
for cell polarity guided anisotropic root growth. eLife. 2021;10. doi:10.7554/elife.72132
apa: Marconi, M., Gallemi, M., Benková, E., & Wabnik, K. (2021). A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth. ELife. eLife Sciences
Publications. https://doi.org/10.7554/elife.72132
chicago: Marconi, Marco, Marçal Gallemi, Eva Benková, and Krzysztof Wabnik. “A Coupled
Mechano-Biochemical Model for Cell Polarity Guided Anisotropic Root Growth.” ELife.
eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.72132.
ieee: M. Marconi, M. Gallemi, E. Benková, and K. Wabnik, “A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth,” eLife, vol. 10.
eLife Sciences Publications, 2021.
ista: Marconi M, Gallemi M, Benková E, Wabnik K. 2021. A coupled mechano-biochemical
model for cell polarity guided anisotropic root growth. eLife. 10, 72132.
mla: Marconi, Marco, et al. “A Coupled Mechano-Biochemical Model for Cell Polarity
Guided Anisotropic Root Growth.” ELife, vol. 10, 72132, eLife Sciences
Publications, 2021, doi:10.7554/elife.72132.
short: M. Marconi, M. Gallemi, E. Benková, K. Wabnik, ELife 10 (2021).
date_created: 2021-11-11T10:05:18Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:49:23Z
day: '01'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.7554/elife.72132
external_id:
isi:
- '000734671200001'
pmid:
- '34723798'
file:
- access_level: open_access
checksum: fad13c509b53bb7a2bef9c946a7ca60a
content_type: application/pdf
creator: dernst
date_created: 2022-05-13T09:00:29Z
date_updated: 2022-05-13T09:00:29Z
file_id: '11372'
file_name: 2021_eLife_Marconi.pdf
file_size: 14137503
relation: main_file
success: 1
file_date_updated: 2022-05-13T09:00:29Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: A coupled mechano-biochemical model for cell polarity guided anisotropic root
growth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10280'
abstract:
- lang: eng
text: 'Machines enabled the Industrial Revolution and are central to modern technological
progress: A machine’s parts transmit forces, motion, and energy to one another
in a predetermined manner. Today’s engineering frontier, building artificial micromachines
that emulate the biological machinery of living organisms, requires faithful assembly
and energy consumption at the microscale. Here, we demonstrate the programmable
assembly of active particles into autonomous metamachines using optical templates.
Metamachines, or machines made of machines, are stable, mobile and autonomous
architectures, whose dynamics stems from the geometry. We use the interplay between
anisotropic force generation of the active colloids with the control of their
orientation by local geometry. This allows autonomous reprogramming of active
particles of the metamachines to achieve multiple functions. It permits the modular
assembly of metamachines by fusion, reconfiguration of metamachines and, we anticipate,
a shift in focus of self-assembly towards active matter and reprogrammable materials.'
acknowledgement: The authors thank R. Jazzar for useful advice regarding the synthesis
of heterodimers. We thank S. Sacanna for critical reading. This material is based
upon work supported by the National Science Foundation under Grant No. DMR-1554724
and Department of Army Research under grant W911NF-20-1-0112.
article_number: '6398'
article_processing_charge: Yes
article_type: original
author:
- first_name: Antoine
full_name: Aubret, Antoine
last_name: Aubret
- first_name: Quentin
full_name: Martinet, Quentin
id: b37485a8-d343-11eb-a0e9-df8c484ef8ab
last_name: Martinet
orcid: 0000-0002-2916-6632
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
citation:
ama: Aubret A, Martinet Q, Palacci JA. Metamachines of pluripotent colloids. Nature
Communications. 2021;12(1). doi:10.1038/s41467-021-26699-6
apa: Aubret, A., Martinet, Q., & Palacci, J. A. (2021). Metamachines of pluripotent
colloids. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-021-26699-6
chicago: Aubret, Antoine, Quentin Martinet, and Jérémie A Palacci. “Metamachines
of Pluripotent Colloids.” Nature Communications. Springer Nature, 2021.
https://doi.org/10.1038/s41467-021-26699-6.
ieee: A. Aubret, Q. Martinet, and J. A. Palacci, “Metamachines of pluripotent colloids,”
Nature Communications, vol. 12, no. 1. Springer Nature, 2021.
ista: Aubret A, Martinet Q, Palacci JA. 2021. Metamachines of pluripotent colloids.
Nature Communications. 12(1), 6398.
mla: Aubret, Antoine, et al. “Metamachines of Pluripotent Colloids.” Nature Communications,
vol. 12, no. 1, 6398, Springer Nature, 2021, doi:10.1038/s41467-021-26699-6.
short: A. Aubret, Q. Martinet, J.A. Palacci, Nature Communications 12 (2021).
date_created: 2021-11-14T23:01:23Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T11:48:37Z
day: '04'
ddc:
- '530'
department:
- _id: JePa
doi: 10.1038/s41467-021-26699-6
external_id:
isi:
- '000714754400010'
pmid:
- '34737315'
file:
- access_level: open_access
checksum: 1c392b12b9b7b615d422d9fabe19cdb9
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-15T13:25:52Z
date_updated: 2021-11-15T13:25:52Z
file_id: '10292'
file_name: 2021_NatComm_Aubret.pdf
file_size: 6282703
relation: main_file
success: 1
file_date_updated: 2021-11-15T13:25:52Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metamachines of pluripotent colloids
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '10283'
abstract:
- lang: eng
text: 'During the past decade, the scientific community and outside observers have
noted a concerning lack of rigor and transparency in preclinical research that
led to talk of a “reproducibility crisis” in the life sciences (Baker, 2016; Bespalov
& Steckler, 2018; Heddleston et al, 2021). Various measures have been proposed
to address the problem: from better training of scientists to more oversight to
expanded publishing practices such as preregistration of studies. The recently
published EQIPD (Enhancing Quality in Preclinical Data) System is, to date, the
largest initiative that aims to establish a systematic approach for increasing
the robustness and reliability of biomedical research (Bespalov et al, 2021).
However, promoting a cultural change in research practices warrants a broad adoption
of the Quality System and its underlying philosophy. It is here that academic
Core Facilities (CF), research service providers at universities and research
institutions, can make a difference. It is fair to assume that a significant fraction
of published data originated from experiments that were designed, run, or analyzed
in CFs. These academic services play an important role in the research ecosystem
by offering access to cutting-edge equipment and by developing and testing novel
techniques and methods that impact research in the academic and private sectors
alike (Bikovski et al, 2020). Equipment and infrastructure are not the only value:
CFs employ competent personnel with profound knowledge and practical experience
of the specific field of interest: animal behavior, imaging, crystallography,
genomics, and so on. Thus, CFs are optimally positioned to address concerns about
the quality and robustness of preclinical research.'
acknowledgement: This EQIPD project has received funding from the Innovative Medicines
Initiative 2 Joint Undertaking under grant agreement no. 777364. This Joint Undertaking
receives support from the European Union’s Horizon 2020 research and innovation
program and EFPIA. LR was supported by the Faculty of Biology and Medicine, University
of Lausanne. VV was supported by Biocenter Finland and the Jane and Aatos Erkko
Foundation. CP and IKB received funding from the Federal Ministry of Education and
Research (BMBF, grant 01PW18001). SB from the Vienna BioCenter Core Facilities (VBCF)
Preclinical Phenotyping Facility acknowledges funding from the Austrian Federal
Ministry of Education, Science & Research; and the City of Vienna. MT is an incumbent
of the Carolito Stiftung Research Fellow Chair in Neurodegenerative Diseases. We
thank Dr. Katja Kivinen (Helsinki Institute of Life Science) for discussions and
feedback.
article_number: e53824
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Leonardo
full_name: Restivo, Leonardo
last_name: Restivo
- first_name: Björn
full_name: Gerlach, Björn
last_name: Gerlach
- first_name: Michael
full_name: Tsoory, Michael
last_name: Tsoory
- first_name: Lior
full_name: Bikovski, Lior
last_name: Bikovski
- first_name: Sylvia
full_name: Badurek, Sylvia
last_name: Badurek
- first_name: Claudia
full_name: Pitzer, Claudia
last_name: Pitzer
- first_name: Isabelle C.
full_name: Kos-Braun, Isabelle C.
last_name: Kos-Braun
- first_name: Anne Laure Mj
full_name: Mausset-Bonnefont, Anne Laure Mj
last_name: Mausset-Bonnefont
- first_name: Jonathan
full_name: Ward, Jonathan
last_name: Ward
- first_name: Michael
full_name: Schunn, Michael
id: 4272DB4A-F248-11E8-B48F-1D18A9856A87
last_name: Schunn
orcid: 0000-0003-4326-5300
- first_name: Lucas P.J.J.
full_name: Noldus, Lucas P.J.J.
last_name: Noldus
- first_name: Anton
full_name: Bespalov, Anton
last_name: Bespalov
- first_name: Vootele
full_name: Voikar, Vootele
last_name: Voikar
citation:
ama: 'Restivo L, Gerlach B, Tsoory M, et al. Towards best practices in research:
Role of academic core facilities. EMBO Reports. 2021;22. doi:10.15252/embr.202153824'
apa: 'Restivo, L., Gerlach, B., Tsoory, M., Bikovski, L., Badurek, S., Pitzer, C.,
… Voikar, V. (2021). Towards best practices in research: Role of academic core
facilities. EMBO Reports. EMBO Press. https://doi.org/10.15252/embr.202153824'
chicago: 'Restivo, Leonardo, Björn Gerlach, Michael Tsoory, Lior Bikovski, Sylvia
Badurek, Claudia Pitzer, Isabelle C. Kos-Braun, et al. “Towards Best Practices
in Research: Role of Academic Core Facilities.” EMBO Reports. EMBO Press,
2021. https://doi.org/10.15252/embr.202153824.'
ieee: 'L. Restivo et al., “Towards best practices in research: Role of academic
core facilities,” EMBO Reports, vol. 22. EMBO Press, 2021.'
ista: 'Restivo L, Gerlach B, Tsoory M, Bikovski L, Badurek S, Pitzer C, Kos-Braun
IC, Mausset-Bonnefont ALM, Ward J, Schunn M, Noldus LPJJ, Bespalov A, Voikar V.
2021. Towards best practices in research: Role of academic core facilities. EMBO
Reports. 22, e53824.'
mla: 'Restivo, Leonardo, et al. “Towards Best Practices in Research: Role of Academic
Core Facilities.” EMBO Reports, vol. 22, e53824, EMBO Press, 2021, doi:10.15252/embr.202153824.'
short: L. Restivo, B. Gerlach, M. Tsoory, L. Bikovski, S. Badurek, C. Pitzer, I.C.
Kos-Braun, A.L.M. Mausset-Bonnefont, J. Ward, M. Schunn, L.P.J.J. Noldus, A. Bespalov,
V. Voikar, EMBO Reports 22 (2021).
date_created: 2021-11-14T23:01:24Z
date_published: 2021-11-04T00:00:00Z
date_updated: 2023-08-14T11:47:35Z
day: '04'
ddc:
- '570'
department:
- _id: PreCl
doi: 10.15252/embr.202153824
external_id:
isi:
- '000714350000001'
file:
- access_level: open_access
checksum: 74743baa6ef431ef60c3de3bc4da045a
content_type: application/pdf
creator: dernst
date_created: 2022-05-16T07:07:41Z
date_updated: 2022-05-16T07:07:41Z
file_id: '11381'
file_name: 2021_EmboReports_Restivo.pdf
file_size: 488583
relation: main_file
success: 1
file_date_updated: 2022-05-16T07:07:41Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '11'
oa: 1
oa_version: Published Version
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
issn:
- 1469-221X
publication_status: published
publisher: EMBO Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards best practices in research: Role of academic core facilities'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2021'
...
---
_id: '10285'
abstract:
- lang: eng
text: We study the overlaps between right and left eigenvectors for random matrices
of the spherical ensemble, as well as truncated unitary ensembles in the regime
where half of the matrix at least is truncated. These two integrable models exhibit
a form of duality, and the essential steps of our investigation can therefore
be performed in parallel. In every case, conditionally on all eigenvalues, diagonal
overlaps are shown to be distributed as a product of independent random variables
with explicit distributions. This enables us to prove that the scaled diagonal
overlaps, conditionally on one eigenvalue, converge in distribution to a heavy-tail
limit, namely, the inverse of a γ2 distribution. We also provide formulae for
the conditional expectation of diagonal and off-diagonal overlaps, either with
respect to one eigenvalue, or with respect to the whole spectrum. These results,
analogous to what is known for the complex Ginibre ensemble, can be obtained in
these cases thanks to integration techniques inspired from a previous work by
Forrester & Krishnapur.
acknowledgement: We acknowledge partial support from the grants NSF DMS-1812114 of
P. Bourgade (PI) and NSF CAREER DMS-1653602 of L.-P. Arguin (PI). This project has
also received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie Grant Agreement No. 754411. We would
like to thank Paul Bourgade and László Erdős for many helpful comments.
article_number: '124'
article_processing_charge: No
article_type: original
author:
- first_name: Guillaume
full_name: Dubach, Guillaume
id: D5C6A458-10C4-11EA-ABF4-A4B43DDC885E
last_name: Dubach
orcid: 0000-0001-6892-8137
citation:
ama: Dubach G. On eigenvector statistics in the spherical and truncated unitary
ensembles. Electronic Journal of Probability. 2021;26. doi:10.1214/21-EJP686
apa: Dubach, G. (2021). On eigenvector statistics in the spherical and truncated
unitary ensembles. Electronic Journal of Probability. Institute of Mathematical
Statistics. https://doi.org/10.1214/21-EJP686
chicago: Dubach, Guillaume. “On Eigenvector Statistics in the Spherical and Truncated
Unitary Ensembles.” Electronic Journal of Probability. Institute of Mathematical
Statistics, 2021. https://doi.org/10.1214/21-EJP686.
ieee: G. Dubach, “On eigenvector statistics in the spherical and truncated unitary
ensembles,” Electronic Journal of Probability, vol. 26. Institute of Mathematical
Statistics, 2021.
ista: Dubach G. 2021. On eigenvector statistics in the spherical and truncated unitary
ensembles. Electronic Journal of Probability. 26, 124.
mla: Dubach, Guillaume. “On Eigenvector Statistics in the Spherical and Truncated
Unitary Ensembles.” Electronic Journal of Probability, vol. 26, 124, Institute
of Mathematical Statistics, 2021, doi:10.1214/21-EJP686.
short: G. Dubach, Electronic Journal of Probability 26 (2021).
date_created: 2021-11-14T23:01:25Z
date_published: 2021-09-28T00:00:00Z
date_updated: 2025-04-14T07:43:47Z
day: '28'
ddc:
- '519'
department:
- _id: LaEr
doi: 10.1214/21-EJP686
ec_funded: 1
file:
- access_level: open_access
checksum: 1c975afb31460277ce4d22b93538e5f9
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-15T10:10:17Z
date_updated: 2021-11-15T10:10:17Z
file_id: '10288'
file_name: 2021_ElecJournalProb_Dubach.pdf
file_size: 735940
relation: main_file
success: 1
file_date_updated: 2021-11-15T10:10:17Z
has_accepted_license: '1'
intvolume: ' 26'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Electronic Journal of Probability
publication_identifier:
eissn:
- 1083-6489
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: On eigenvector statistics in the spherical and truncated unitary ensembles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 26
year: '2021'
...
---
_id: '10290'
abstract:
- lang: eng
text: A precise quantitative description of the ultrastructural characteristics
underlying biological mechanisms is often key to their understanding. This is
particularly true for dynamic extra- and intracellular filamentous assemblies,
playing a role in cell motility, cell integrity, cytokinesis, tissue formation
and maintenance. For example, genetic manipulation or modulation of actin regulatory
proteins frequently manifests in changes of the morphology, dynamics, and ultrastructural
architecture of actin filament-rich cell peripheral structures, such as lamellipodia
or filopodia. However, the observed ultrastructural effects often remain subtle
and require sufficiently large datasets for appropriate quantitative analysis.
The acquisition of such large datasets has been enabled by recent advances in
high-throughput cryo-electron tomography (cryo-ET) methods. This also necessitates
the development of complementary approaches to maximize the extraction of relevant
biological information. We have developed a computational toolbox for the semi-automatic
quantification of segmented and vectorized filamentous networks from pre-processed
cryo-electron tomograms, facilitating the analysis and cross-comparison of multiple
experimental conditions. GUI-based components simplify the processing of data
and allow users to obtain a large number of ultrastructural parameters describing
filamentous assemblies. We demonstrate the feasibility of this workflow by analyzing
cryo-ET data of untreated and chemically perturbed branched actin filament networks
and that of parallel actin filament arrays. In principle, the computational toolbox
presented here is applicable for data analysis comprising any type of filaments
in regular (i.e. parallel) or random arrangement. We show that it can ease the
identification of key differences between experimental groups and facilitate the
in-depth analysis of ultrastructural data in a time-efficient manner.
acknowledged_ssus:
- _id: ScienComp
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: 'This research was supported by the Scientific Service Units (SSUs)
of IST Austria through resources provided by Scientific Computing (SciComp), the
Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy
Facility (EMF). We also thank Victor-Valentin Hodirnau for help with cryo-ET data
acquisition. The authors acknowledge support from IST Austria and from the Austrian
Science Fund (FWF): M02495 to G.D. and Austrian Science Fund (FWF): P33367 to F.K.M.S.'
article_number: '107808'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Georgi A
full_name: Dimchev, Georgi A
id: 38C393BE-F248-11E8-B48F-1D18A9856A87
last_name: Dimchev
orcid: 0000-0001-8370-6161
- first_name: Behnam
full_name: Amiri, Behnam
last_name: Amiri
- first_name: Florian
full_name: Fäßler, Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- first_name: Martin
full_name: Falcke, Martin
last_name: Falcke
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. Computational toolbox for
ultrastructural quantitative analysis of filament networks in cryo-ET data. Journal
of Structural Biology. 2021;213(4). doi:10.1016/j.jsb.2021.107808
apa: Dimchev, G. A., Amiri, B., Fäßler, F., Falcke, M., & Schur, F. K. (2021).
Computational toolbox for ultrastructural quantitative analysis of filament networks
in cryo-ET data. Journal of Structural Biology. Elsevier . https://doi.org/10.1016/j.jsb.2021.107808
chicago: Dimchev, Georgi A, Behnam Amiri, Florian Fäßler, Martin Falcke, and Florian
KM Schur. “Computational Toolbox for Ultrastructural Quantitative Analysis of
Filament Networks in Cryo-ET Data.” Journal of Structural Biology. Elsevier
, 2021. https://doi.org/10.1016/j.jsb.2021.107808.
ieee: G. A. Dimchev, B. Amiri, F. Fäßler, M. Falcke, and F. K. Schur, “Computational
toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET
data,” Journal of Structural Biology, vol. 213, no. 4. Elsevier , 2021.
ista: Dimchev GA, Amiri B, Fäßler F, Falcke M, Schur FK. 2021. Computational toolbox
for ultrastructural quantitative analysis of filament networks in cryo-ET data.
Journal of Structural Biology. 213(4), 107808.
mla: Dimchev, Georgi A., et al. “Computational Toolbox for Ultrastructural Quantitative
Analysis of Filament Networks in Cryo-ET Data.” Journal of Structural Biology,
vol. 213, no. 4, 107808, Elsevier , 2021, doi:10.1016/j.jsb.2021.107808.
short: G.A. Dimchev, B. Amiri, F. Fäßler, M. Falcke, F.K. Schur, Journal of Structural
Biology 213 (2021).
corr_author: '1'
date_created: 2021-11-15T12:21:42Z
date_published: 2021-11-03T00:00:00Z
date_updated: 2025-04-15T08:25:41Z
day: '03'
ddc:
- '572'
department:
- _id: FlSc
doi: 10.1016/j.jsb.2021.107808
external_id:
isi:
- '000720259500002'
file:
- access_level: open_access
checksum: 6b209e4d44775d4e02b50f78982c15fa
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-15T13:11:27Z
date_updated: 2021-11-15T13:11:27Z
file_id: '10291'
file_name: 2021_JournalStructBiol_Dimchev.pdf
file_size: 16818304
relation: main_file
success: 1
file_date_updated: 2021-11-15T13:11:27Z
has_accepted_license: '1'
intvolume: ' 213'
isi: 1
issue: '4'
keyword:
- Structural Biology
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
- _id: 2674F658-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02495
name: Protein structure and function in filopodia across scales
publication: Journal of Structural Biology
publication_identifier:
issn:
- 1047-8477
publication_status: published
publisher: 'Elsevier '
quality_controlled: '1'
related_material:
record:
- id: '14502'
relation: software
status: public
scopus_import: '1'
status: public
title: Computational toolbox for ultrastructural quantitative analysis of filament
networks in cryo-ET data
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 213
year: '2021'
...
---
_id: '10301'
abstract:
- lang: eng
text: De novo protein synthesis is required for synapse modifications underlying
stable memory encoding. Yet neurons are highly compartmentalized cells and how
protein synthesis can be regulated at the synapse level is unknown. Here, we characterize
neuronal signaling complexes formed by the postsynaptic scaffold GIT1, the mechanistic
target of rapamycin (mTOR) kinase, and Raptor that couple synaptic stimuli to
mTOR-dependent protein synthesis; and identify NMDA receptors containing GluN3A
subunits as key negative regulators of GIT1 binding to mTOR. Disruption of GIT1/mTOR
complexes by enhancing GluN3A expression or silencing GIT1 inhibits synaptic mTOR
activation and restricts the mTOR-dependent translation of specific activity-regulated
mRNAs. Conversely, GluN3A removal enables complex formation, potentiates mTOR-dependent
protein synthesis, and facilitates the consolidation of associative and spatial
memories in mice. The memory enhancement becomes evident with light or spaced
training, can be achieved by selectively deleting GluN3A from excitatory neurons
during adulthood, and does not compromise other aspects of cognition such as memory
flexibility or extinction. Our findings provide mechanistic insight into synaptic
translational control and reveal a potentially selective target for cognitive
enhancement.
acknowledgement: We thank Stuart Lipton and Nobuki Nakanishi for providing the Grin3a
knockout mice, Beverly Davidson for the AAV-caRheb, Jose Esteban for help with behavioral
and biochemical experiments, and Noelia Campillo, Rebeca Martínez-Turrillas, and
Ana Navarro for expert technical help. Work was funded by the UTE project CIMA;
fellowships from the Fundación Tatiana Pérez de Guzmán el Bueno, FEBS, and IBRO
(to M.J.C.D.), Generalitat Valenciana (to O.E.-Z.), Juan de la Cierva (to L.G.R.),
FPI-MINECO (to E.R.V., to S.N.) and Intertalentum postdoctoral program (to V.B.);
ANR (GluBrain3A) and ERC Advanced Grants (#693021) (to P.P.); Ramón y Cajal program
RYC2014-15784, RETOS-MINECO SAF2016-76565-R, ERANET-Neuron JTC 2019 ISCIII AC19/00077
FEDER funds (to R.A.); RETOS-MINECO SAF2017-87928-R (to A.B.); an NIH grant (NS76637)
and UTHSC College of Medicine funds (to S.J.T.); and NARSAD Independent Investigator
Award and grants from the MINECO (CSD2008-00005, SAF2013-48983R, SAF2016-80895-R),
Generalitat Valenciana (PROMETEO 2019/020)(to I.P.O.) and Severo-Ochoa Excellence
Awards (SEV-2013-0317, SEV-2017-0723).
article_number: e71575
article_processing_charge: No
article_type: original
author:
- first_name: María J
full_name: Conde-Dusman, María J
last_name: Conde-Dusman
- first_name: Partha N
full_name: Dey, Partha N
last_name: Dey
- first_name: Óscar
full_name: Elía-Zudaire, Óscar
last_name: Elía-Zudaire
- first_name: Luis E
full_name: Garcia Rabaneda, Luis E
id: 33D1B084-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Rabaneda
- first_name: Carmen
full_name: García-Lira, Carmen
last_name: García-Lira
- first_name: Teddy
full_name: Grand, Teddy
last_name: Grand
- first_name: Victor
full_name: Briz, Victor
last_name: Briz
- first_name: Eric R
full_name: Velasco, Eric R
last_name: Velasco
- first_name: Raül
full_name: Andero Galí, Raül
last_name: Andero Galí
- first_name: Sergio
full_name: Niñerola, Sergio
last_name: Niñerola
- first_name: Angel
full_name: Barco, Angel
last_name: Barco
- first_name: Pierre
full_name: Paoletti, Pierre
last_name: Paoletti
- first_name: John F
full_name: Wesseling, John F
last_name: Wesseling
- first_name: Fabrizio
full_name: Gardoni, Fabrizio
last_name: Gardoni
- first_name: Steven J
full_name: Tavalin, Steven J
last_name: Tavalin
- first_name: Isabel
full_name: Perez-Otaño, Isabel
last_name: Perez-Otaño
citation:
ama: Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, et al. Control of protein synthesis
and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
eLife. 2021;10. doi:10.7554/elife.71575
apa: Conde-Dusman, M. J., Dey, P. N., Elía-Zudaire, Ó., Garcia Rabaneda, L. E.,
García-Lira, C., Grand, T., … Perez-Otaño, I. (2021). Control of protein synthesis
and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.71575
chicago: Conde-Dusman, María J, Partha N Dey, Óscar Elía-Zudaire, Luis E Garcia
Rabaneda, Carmen García-Lira, Teddy Grand, Victor Briz, et al. “Control of Protein
Synthesis and Memory by GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1
Assembly.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.71575.
ieee: M. J. Conde-Dusman et al., “Control of protein synthesis and memory
by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly,” eLife,
vol. 10. eLife Sciences Publications, 2021.
ista: Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Garcia Rabaneda LE, García-Lira C,
Grand T, Briz V, Velasco ER, Andero Galí R, Niñerola S, Barco A, Paoletti P, Wesseling
JF, Gardoni F, Tavalin SJ, Perez-Otaño I. 2021. Control of protein synthesis and
memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly. eLife.
10, e71575.
mla: Conde-Dusman, María J., et al. “Control of Protein Synthesis and Memory by
GluN3A-NMDA Receptors through Inhibition of GIT1/MTORC1 Assembly.” ELife,
vol. 10, e71575, eLife Sciences Publications, 2021, doi:10.7554/elife.71575.
short: M.J. Conde-Dusman, P.N. Dey, Ó. Elía-Zudaire, L.E. Garcia Rabaneda, C. García-Lira,
T. Grand, V. Briz, E.R. Velasco, R. Andero Galí, S. Niñerola, A. Barco, P. Paoletti,
J.F. Wesseling, F. Gardoni, S.J. Tavalin, I. Perez-Otaño, ELife 10 (2021).
date_created: 2021-11-18T06:59:45Z
date_published: 2021-11-17T00:00:00Z
date_updated: 2024-10-21T06:02:05Z
day: '17'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.7554/elife.71575
external_id:
isi:
- '000720945900001'
file:
- access_level: open_access
checksum: 59318e9e41507cec83c2f4070e6ad540
content_type: application/pdf
creator: lgarciar
date_created: 2021-11-18T07:02:02Z
date_updated: 2021-11-18T07:02:02Z
file_id: '10302'
file_name: elife-71575-v1.pdf
file_size: 2477302
relation: main_file
success: 1
file_date_updated: 2021-11-18T07:02:02Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- general immunology and microbiology
- general biochemistry
- genetics and molecular biology
- general medicine
- general neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition
of GIT1/mTORC1 assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '10310'
abstract:
- lang: eng
text: A high-resolution structure of trimeric cyanobacterial Photosystem I (PSI)
from Thermosynechococcus elongatus was reported as the first atomic model of PSI
almost 20 years ago. However, the monomeric PSI structure has not yet been reported
despite long-standing interest in its structure and extensive spectroscopic characterization
of the loss of red chlorophylls upon monomerization. Here, we describe the structure
of monomeric PSI from Thermosynechococcus elongatus BP-1. Comparison with the
trimer structure gave detailed insights into monomerization-induced changes in
both the central trimerization domain and the peripheral regions of the complex.
Monomerization-induced loss of red chlorophylls is assigned to a cluster of chlorophylls
adjacent to PsaX. Based on our findings, we propose a role of PsaX in the stabilization
of red chlorophylls and that lipids of the surrounding membrane present a major
source of thermal energy for uphill excitation energy transfer from red chlorophylls
to P700.
acknowledgement: We are grateful for additional support and valuable scientific input
for this project by Yuko Misumi, Jiannan Li, Hisako Kubota-Kawai, Takeshi Kawabata,
Mian Wu, Eiki Yamashita, Atsushi Nakagawa, Volker Hartmann, Melanie Völkel and Matthias
Rögner. Parts of this research were funded by the German Research Council (DFG)
within the framework of GRK 2341 (Microbial Substrate Conversion) to M.M.N., the
Platform Project for Supporting Drug Discovery and Life Science Research [Basis
for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from
AMED under grant number JP20am0101117 (K.N.), JP16K07266 to Atsunori Oshima and
C.G., a Grants-in-Aid for Scientific Research under grant number JP 25000013 (K.N.),
17H03647 (C.G.) and 16H06560 (G.K.) from MEXT-KAKENHI, the International Joint Research
Promotion Program from Osaka University to M.M.N., C.G. and G.K., and the Cyclic
Innovation for Clinical Empowerment (CiCLE) Grant Number JP17pc0101020 from AMED
to K.N. and G.K.
article_number: '304'
article_processing_charge: No
article_type: original
author:
- first_name: Mehmet Orkun
full_name: Çoruh, Mehmet Orkun
id: d25163e5-8d53-11eb-a251-e6dd8ea1b8ef
last_name: Çoruh
orcid: 0000-0002-3219-2022
- first_name: Anna
full_name: Frank, Anna
last_name: Frank
- first_name: Hideaki
full_name: Tanaka, Hideaki
last_name: Tanaka
- first_name: Akihiro
full_name: Kawamoto, Akihiro
last_name: Kawamoto
- first_name: Eithar
full_name: El-Mohsnawy, Eithar
last_name: El-Mohsnawy
- first_name: Takayuki
full_name: Kato, Takayuki
last_name: Kato
- first_name: Keiichi
full_name: Namba, Keiichi
last_name: Namba
- first_name: Christoph
full_name: Gerle, Christoph
last_name: Gerle
- first_name: Marc M.
full_name: Nowaczyk, Marc M.
last_name: Nowaczyk
- first_name: Genji
full_name: Kurisu, Genji
last_name: Kurisu
citation:
ama: Çoruh MO, Frank A, Tanaka H, et al. Cryo-EM structure of a functional monomeric
Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster.
Communications Biology. 2021;4(1). doi:10.1038/s42003-021-01808-9
apa: Çoruh, M. O., Frank, A., Tanaka, H., Kawamoto, A., El-Mohsnawy, E., Kato, T.,
… Kurisu, G. (2021). Cryo-EM structure of a functional monomeric Photosystem I
from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications
Biology. Springer . https://doi.org/10.1038/s42003-021-01808-9
chicago: Çoruh, Mehmet Orkun, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar
El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M. Nowaczyk,
and Genji Kurisu. “Cryo-EM Structure of a Functional Monomeric Photosystem I from
Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” Communications
Biology. Springer , 2021. https://doi.org/10.1038/s42003-021-01808-9.
ieee: M. O. Çoruh et al., “Cryo-EM structure of a functional monomeric Photosystem
I from Thermosynechococcus elongatus reveals red chlorophyll cluster,” Communications
Biology, vol. 4, no. 1. Springer , 2021.
ista: Çoruh MO, Frank A, Tanaka H, Kawamoto A, El-Mohsnawy E, Kato T, Namba K, Gerle
C, Nowaczyk MM, Kurisu G. 2021. Cryo-EM structure of a functional monomeric Photosystem
I from Thermosynechococcus elongatus reveals red chlorophyll cluster. Communications
Biology. 4(1), 304.
mla: Çoruh, Mehmet Orkun, et al. “Cryo-EM Structure of a Functional Monomeric Photosystem
I from Thermosynechococcus Elongatus Reveals Red Chlorophyll Cluster.” Communications
Biology, vol. 4, no. 1, 304, Springer , 2021, doi:10.1038/s42003-021-01808-9.
short: M.O. Çoruh, A. Frank, H. Tanaka, A. Kawamoto, E. El-Mohsnawy, T. Kato, K.
Namba, C. Gerle, M.M. Nowaczyk, G. Kurisu, Communications Biology 4 (2021).
date_created: 2021-11-19T11:37:29Z
date_published: 2021-03-08T00:00:00Z
date_updated: 2023-08-14T11:51:19Z
day: '08'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1038/s42003-021-01808-9
external_id:
isi:
- '000627440700001'
pmid:
- '33686186'
file:
- access_level: open_access
checksum: 8ffd39f2bba7152a2441802ff313bf0b
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-19T15:09:18Z
date_updated: 2021-11-19T15:09:18Z
file_id: '10318'
file_name: 2021_CommBio_Çoruh.pdf
file_size: 6030261
relation: main_file
success: 1
file_date_updated: 2021-11-19T15:09:18Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '1'
keyword:
- general agricultural and biological Sciences
- general biochemistry
- genetics and molecular biology
- medicine (miscellaneous)
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Communications Biology
publication_identifier:
issn:
- 2399-3642
publication_status: published
publisher: 'Springer '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus
elongatus reveals red chlorophyll cluster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 4
year: '2021'
...
---
_id: '10322'
abstract:
- lang: eng
text: To survive elevated temperatures, ectotherms adjust the fluidity of membranes
by fine-tuning lipid desaturation levels in a process previously described to
be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal
heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock
response (HSR), causes extensive fat remodeling in peripheral tissues. These changes
include a decrease in fat desaturase and acid lipase expression in the intestine
and a global shift in the saturation levels of plasma membrane’s phospholipids.
The observed remodeling of plasma membrane is in line with ectothermic adaptive
responses and gives worms a cumulative advantage to warm temperatures. We have
determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated
channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone
morphogenetic protein (BMP) are required for signaling across tissues to modulate
fat desaturation. We also find neuronal hsf-1 is not only sufficient but also
partially necessary to control the fat remodeling response and for survival at
warm temperatures. This is the first study to show that a thermostat-based mechanism
can cell nonautonomously coordinate membrane saturation and composition across
tissues in a multicellular animal.
acknowledgement: We dedicate this work to the memory of Michael J.O. Wakelam. We would
like to acknowledge Michael Fasseas (Invermis, Magnitude Biosciences) for plasmid
injections and Sunny Biotech for transgenics; Catalina Vallejos and John Marioni
for statistical advice at the beginning of the work; Simon Walker, Imaging, Bioinformatics
and Lipidomics Facilities at Babraham Institute for technical support; and Cindy
Voisine, Michael Witting, Jon Houseley, Len Stephens, Carmen Nussbaum Krammer, Rebeca
Aldunate, Patricija van Oosten-Hawle, Jean-Louis Bessereau, and Jane Alfred for
feedback on the manuscript. We thank Andy Dillin, Atsushi Kuhara, Amy Walker, Andrew
Leifer, Yun Zhang, and Michalis Barkoulas for reagents and Julie Ahringer, Anne
Ferguson-Smith, and Anne Corcoran for support and helpful discussions. We also acknowledge
Babraham Institute Facilities.
article_number: e3001431
article_processing_charge: No
article_type: original
author:
- first_name: Laetitia
full_name: Chauve, Laetitia
last_name: Chauve
- first_name: Francesca
full_name: Hodge, Francesca
last_name: Hodge
- first_name: Sharlene
full_name: Murdoch, Sharlene
last_name: Murdoch
- first_name: Fatemah
full_name: Masoudzadeh, Fatemah
last_name: Masoudzadeh
- first_name: Harry Jack
full_name: Mann, Harry Jack
last_name: Mann
- first_name: Andrea
full_name: Lopez-Clavijo, Andrea
last_name: Lopez-Clavijo
- first_name: Hanneke
full_name: Okkenhaug, Hanneke
last_name: Okkenhaug
- first_name: Greg
full_name: West, Greg
last_name: West
- first_name: Bebiana C.
full_name: Sousa, Bebiana C.
last_name: Sousa
- first_name: Anne
full_name: Segonds-Pichon, Anne
last_name: Segonds-Pichon
- first_name: Cheryl
full_name: Li, Cheryl
last_name: Li
- first_name: Steven
full_name: Wingett, Steven
last_name: Wingett
- first_name: Hermine
full_name: Kienberger, Hermine
last_name: Kienberger
- first_name: Karin
full_name: Kleigrewe, Karin
last_name: Kleigrewe
- first_name: Mario
full_name: De Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: De Bono
orcid: 0000-0001-8347-0443
- first_name: Michael
full_name: Wakelam, Michael
last_name: Wakelam
- first_name: Olivia
full_name: Casanueva, Olivia
last_name: Casanueva
citation:
ama: Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans. PLoS Biology. 2021;19(11). doi:10.1371/journal.pbio.3001431
apa: Chauve, L., Hodge, F., Murdoch, S., Masoudzadeh, F., Mann, H. J., Lopez-Clavijo,
A., … Casanueva, O. (2021). Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans.
PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.3001431
chicago: Chauve, Laetitia, Francesca Hodge, Sharlene Murdoch, Fatemah Masoudzadeh,
Harry Jack Mann, Andrea Lopez-Clavijo, Hanneke Okkenhaug, et al. “Neuronal HSF-1
Coordinates the Propagation of Fat Desaturation across Tissues to Enable Adaptation
to High Temperatures in C. Elegans.” PLoS Biology. Public Library of Science,
2021. https://doi.org/10.1371/journal.pbio.3001431.
ieee: L. Chauve et al., “Neuronal HSF-1 coordinates the propagation of fat
desaturation across tissues to enable adaptation to high temperatures in C. elegans,”
PLoS Biology, vol. 19, no. 11. Public Library of Science, 2021.
ista: Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann HJ, Lopez-Clavijo A, Okkenhaug
H, West G, Sousa BC, Segonds-Pichon A, Li C, Wingett S, Kienberger H, Kleigrewe
K, de Bono M, Wakelam M, Casanueva O. 2021. Neuronal HSF-1 coordinates the propagation
of fat desaturation across tissues to enable adaptation to high temperatures in
C. elegans. PLoS Biology. 19(11), e3001431.
mla: Chauve, Laetitia, et al. “Neuronal HSF-1 Coordinates the Propagation of Fat
Desaturation across Tissues to Enable Adaptation to High Temperatures in C. Elegans.”
PLoS Biology, vol. 19, no. 11, e3001431, Public Library of Science, 2021,
doi:10.1371/journal.pbio.3001431.
short: L. Chauve, F. Hodge, S. Murdoch, F. Masoudzadeh, H.J. Mann, A. Lopez-Clavijo,
H. Okkenhaug, G. West, B.C. Sousa, A. Segonds-Pichon, C. Li, S. Wingett, H. Kienberger,
K. Kleigrewe, M. de Bono, M. Wakelam, O. Casanueva, PLoS Biology 19 (2021).
date_created: 2021-11-21T23:01:28Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T11:53:27Z
day: '01'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1371/journal.pbio.3001431
external_id:
isi:
- '000715818400001'
pmid:
- '34723964'
file:
- access_level: open_access
checksum: 0c61b667f814fd9435b3ac42036fc36d
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-22T09:34:03Z
date_updated: 2021-11-22T09:34:03Z
file_id: '10330'
file_name: 2021_PLoSBio_Chauve.pdf
file_size: 4069215
relation: main_file
success: 1
file_date_updated: 2021-11-22T09:34:03Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Biology
publication_identifier:
eissn:
- 1545-7885
issn:
- 1544-9173
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '13069'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues
to enable adaptation to high temperatures in C. elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2021'
...
---
_id: '10323'
abstract:
- lang: eng
text: Molecular chaperones are central to cellular protein homeostasis. Dynamic
disorder is a key feature of the complexes of molecular chaperones and their client
proteins, and it facilitates the client release towards a folded state or the
handover to downstream components. The dynamic nature also implies that a given
chaperone can interact with many different client proteins, based on physico-chemical
sequence properties rather than on structural complementarity of their (folded)
3D structure. Yet, the balance between this promiscuity and some degree of client
specificity is poorly understood. Here, we review recent atomic-level descriptions
of chaperones with client proteins, including chaperones in complex with intrinsically
disordered proteins, with membrane-protein precursors, or partially folded client
proteins. We focus hereby on chaperone-client interactions that are independent
of ATP. The picture emerging from these studies highlights the importance of dynamics
in these complexes, whereby several interaction types, not only hydrophobic ones,
contribute to the complex formation. We discuss these features of chaperone-client
complexes and possible factors that may contribute to this balance of promiscuity
and specificity.
acknowledgement: We thank Juan C. Fontecilla-Camps for insightful discussions related
to ATP-driven machineries, and Elif Karagöz for providing the structural model of
the Hsp90-Tau complex. This study was supported by the European Research Council
(StG-2012-311318-ProtDyn2Function) and the Agence Nationale de la Recherche (ANR-18-CE92-0032-MitoMemProtImp).
article_number: '762005'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Iva
full_name: Sučec, Iva
last_name: Sučec
- first_name: Beate
full_name: Bersch, Beate
last_name: Bersch
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Sučec I, Bersch B, Schanda P. How do chaperones bind (partly) unfolded client
proteins? Frontiers in Molecular Biosciences. 2021;8. doi:10.3389/fmolb.2021.762005
apa: Sučec, I., Bersch, B., & Schanda, P. (2021). How do chaperones bind (partly)
unfolded client proteins? Frontiers in Molecular Biosciences. Frontiers.
https://doi.org/10.3389/fmolb.2021.762005
chicago: Sučec, Iva, Beate Bersch, and Paul Schanda. “How Do Chaperones Bind (Partly)
Unfolded Client Proteins?” Frontiers in Molecular Biosciences. Frontiers,
2021. https://doi.org/10.3389/fmolb.2021.762005.
ieee: I. Sučec, B. Bersch, and P. Schanda, “How do chaperones bind (partly) unfolded
client proteins?,” Frontiers in Molecular Biosciences, vol. 8. Frontiers,
2021.
ista: Sučec I, Bersch B, Schanda P. 2021. How do chaperones bind (partly) unfolded
client proteins? Frontiers in Molecular Biosciences. 8, 762005.
mla: Sučec, Iva, et al. “How Do Chaperones Bind (Partly) Unfolded Client Proteins?”
Frontiers in Molecular Biosciences, vol. 8, 762005, Frontiers, 2021, doi:10.3389/fmolb.2021.762005.
short: I. Sučec, B. Bersch, P. Schanda, Frontiers in Molecular Biosciences 8 (2021).
corr_author: '1'
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-25T00:00:00Z
date_updated: 2024-10-09T21:01:12Z
day: '25'
ddc:
- '547'
department:
- _id: PaSc
doi: 10.3389/fmolb.2021.762005
external_id:
isi:
- '000717241700001'
pmid:
- '34760928'
file:
- access_level: open_access
checksum: a5c9dbf80dc2c5aaa737f456c941d964
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-23T15:06:58Z
date_updated: 2021-11-23T15:06:58Z
file_id: '10333'
file_name: 2021_FrontiersMolBioSc_Sučec.pdf
file_size: 4700798
relation: main_file
success: 1
file_date_updated: 2021-11-23T15:06:58Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Molecular Biosciences
publication_identifier:
eissn:
- 2296-889X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: How do chaperones bind (partly) unfolded client proteins?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2021'
...
---
_id: '10324'
abstract:
- lang: eng
text: Off-chain protocols (channels) are a promising solution to the scalability
and privacy challenges of blockchain payments. Current proposals, however, require
synchrony assumptions to preserve the safety of a channel, leaking to an adversary
the exact amount of time needed to control the network for a successful attack.
In this paper, we introduce Brick, the first payment channel that remains secure
under network asynchrony and concurrently provides correct incentives. The core
idea is to incorporate the conflict resolution process within the channel by introducing
a rational committee of external parties, called wardens. Hence, if a party wants
to close a channel unilaterally, it can only get the committee’s approval for
the last valid state. Additionally, Brick provides sub-second latency because
it does not employ heavy-weight consensus. Instead, Brick uses consistent broadcast
to announce updates and close the channel, a light-weight abstraction that is
powerful enough to preserve safety and liveness to any rational parties. We formally
define and prove for Brick the properties a payment channel construction should
fulfill. We also design incentives for Brick such that honest and rational behavior
aligns. Finally, we provide a reference implementation of the smart contracts
in Solidity.
acknowledgement: We would like to thank Kaoutar Elkhiyaoui for her valuable feedback
as well as Jakub Sliwinski for his impactful contribution to this work.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Zeta
full_name: Avarikioti, Zeta
last_name: Avarikioti
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Roger
full_name: Wattenhofer, Roger
last_name: Wattenhofer
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
citation:
ama: 'Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. Brick: Asynchronous
incentive-compatible payment channels. In: 25th International Conference on
Financial Cryptography and Data Security. Vol 12675. Springer Nature; 2021:209-230.
doi:10.1007/978-3-662-64331-0_11'
apa: 'Avarikioti, Z., Kokoris Kogias, E., Wattenhofer, R., & Zindros, D. (2021).
Brick: Asynchronous incentive-compatible payment channels. In 25th International
Conference on Financial Cryptography and Data Security (Vol. 12675, pp. 209–230).
Virtual: Springer Nature. https://doi.org/10.1007/978-3-662-64331-0_11'
chicago: 'Avarikioti, Zeta, Eleftherios Kokoris Kogias, Roger Wattenhofer, and Dionysis
Zindros. “Brick: Asynchronous Incentive-Compatible Payment Channels.” In 25th
International Conference on Financial Cryptography and Data Security, 12675:209–30.
Springer Nature, 2021. https://doi.org/10.1007/978-3-662-64331-0_11.'
ieee: 'Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, and D. Zindros, “Brick:
Asynchronous incentive-compatible payment channels,” in 25th International
Conference on Financial Cryptography and Data Security, Virtual, 2021, vol.
12675, pp. 209–230.'
ista: 'Avarikioti Z, Kokoris Kogias E, Wattenhofer R, Zindros D. 2021. Brick: Asynchronous
incentive-compatible payment channels. 25th International Conference on Financial
Cryptography and Data Security. FC: Financial Cryptography, LNCS, vol. 12675,
209–230.'
mla: 'Avarikioti, Zeta, et al. “Brick: Asynchronous Incentive-Compatible Payment
Channels.” 25th International Conference on Financial Cryptography and Data
Security, vol. 12675, Springer Nature, 2021, pp. 209–30, doi:10.1007/978-3-662-64331-0_11.'
short: Z. Avarikioti, E. Kokoris Kogias, R. Wattenhofer, D. Zindros, in:, 25th International
Conference on Financial Cryptography and Data Security, Springer Nature, 2021,
pp. 209–230.
conference:
end_date: 2021-03-05
location: Virtual
name: 'FC: Financial Cryptography'
start_date: 2021-03-01
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-23T00:00:00Z
date_updated: 2023-08-14T12:59:58Z
day: '23'
department:
- _id: ElKo
doi: 10.1007/978-3-662-64331-0_11
external_id:
arxiv:
- '1905.11360'
isi:
- '000712016200011'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.11360
month: '10'
oa: 1
oa_version: Preprint
page: 209-230
publication: 25th International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- 978-3-662-64331-0
eissn:
- 1611-3349
isbn:
- 9-783-6626-4330-3
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Brick: Asynchronous incentive-compatible payment channels'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: '12675 '
year: '2021'
...
---
_id: '10325'
abstract:
- lang: eng
text: Since the inception of Bitcoin, a plethora of distributed ledgers differing
in design and purpose has been created. While by design, blockchains provide no
means to securely communicate with external systems, numerous attempts towards
trustless cross-chain communication have been proposed over the years. Today,
cross-chain communication (CCC) plays a fundamental role in cryptocurrency exchanges,
scalability efforts via sharding, extension of existing systems through sidechains,
and bootstrapping of new blockchains. Unfortunately, existing proposals are designed
ad-hoc for specific use-cases, making it hard to gain confidence in their correctness
and composability. We provide the first systematic exposition of cross-chain communication
protocols. We formalize the underlying research problem and show that CCC is impossible
without a trusted third party, contrary to common beliefs in the blockchain community.
With this result in mind, we develop a framework to design new and evaluate existing
CCC protocols, focusing on the inherent trust assumptions thereof, and derive
a classification covering the field of cross-chain communication to date. We conclude
by discussing open challenges for CCC research and the implications of interoperability
on the security and privacy of blockchains.
acknowledgement: 'We would like express our gratitude to Georgia Avarikioti, Daniel
Perez and Dominik Harz for helpful comments and feedback on earlier versions of
this manuscript. We also thank Nicholas Stifter, Aljosha Judmayer, Philipp Schindler,
Edgar Weippl, and Alistair Stewart for insightful discussions during the early stages
of this research. We also wish to thank the anonymous reviewers for their valuable
comments that helped improve the presentation of our results. This research was
funded by Bridge 1 858561 SESC; Bridge 1 864738 PR4DLT (all FFG); the Christian
Doppler Laboratory for Security and Quality Improvement in the Production System
Lifecycle (CDL-SQI); the competence center SBA-K1 funded by COMET; Chaincode Labs
through the project SLN: Scalability for the Lightning Network; and by the Austrian
Science Fund (FWF) through the Meitner program (project M-2608). Mustafa Al-Bassam
is funded by a scholarship from the Alan Turing Institute. Alexei Zamyatin conducted
the early stages of this work during his time at SBA Research, and was supported
by a Binance Research Fellowship.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Alexei
full_name: Zamyatin, Alexei
last_name: Zamyatin
- first_name: Mustafa
full_name: Al-Bassam, Mustafa
last_name: Al-Bassam
- first_name: Dionysis
full_name: Zindros, Dionysis
last_name: Zindros
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
- first_name: Pedro
full_name: Moreno-Sanchez, Pedro
last_name: Moreno-Sanchez
- first_name: Aggelos
full_name: Kiayias, Aggelos
last_name: Kiayias
- first_name: William J.
full_name: Knottenbelt, William J.
last_name: Knottenbelt
citation:
ama: 'Zamyatin A, Al-Bassam M, Zindros D, et al. SoK: Communication across distributed
ledgers. In: 25th International Conference on Financial Cryptography and Data
Security. Vol 12675. Springer Nature; 2021:3-36. doi:10.1007/978-3-662-64331-0_1'
apa: 'Zamyatin, A., Al-Bassam, M., Zindros, D., Kokoris Kogias, E., Moreno-Sanchez,
P., Kiayias, A., & Knottenbelt, W. J. (2021). SoK: Communication across distributed
ledgers. In 25th International Conference on Financial Cryptography and Data
Security (Vol. 12675, pp. 3–36). Virtual: Springer Nature. https://doi.org/10.1007/978-3-662-64331-0_1'
chicago: 'Zamyatin, Alexei, Mustafa Al-Bassam, Dionysis Zindros, Eleftherios Kokoris
Kogias, Pedro Moreno-Sanchez, Aggelos Kiayias, and William J. Knottenbelt. “SoK:
Communication across Distributed Ledgers.” In 25th International Conference
on Financial Cryptography and Data Security, 12675:3–36. Springer Nature,
2021. https://doi.org/10.1007/978-3-662-64331-0_1.'
ieee: 'A. Zamyatin et al., “SoK: Communication across distributed ledgers,”
in 25th International Conference on Financial Cryptography and Data Security,
Virtual, 2021, vol. 12675, pp. 3–36.'
ista: 'Zamyatin A, Al-Bassam M, Zindros D, Kokoris Kogias E, Moreno-Sanchez P, Kiayias
A, Knottenbelt WJ. 2021. SoK: Communication across distributed ledgers. 25th International
Conference on Financial Cryptography and Data Security. FC: Financial Cryptography,
LNCS, vol. 12675, 3–36.'
mla: 'Zamyatin, Alexei, et al. “SoK: Communication across Distributed Ledgers.”
25th International Conference on Financial Cryptography and Data Security,
vol. 12675, Springer Nature, 2021, pp. 3–36, doi:10.1007/978-3-662-64331-0_1.'
short: A. Zamyatin, M. Al-Bassam, D. Zindros, E. Kokoris Kogias, P. Moreno-Sanchez,
A. Kiayias, W.J. Knottenbelt, in:, 25th International Conference on Financial
Cryptography and Data Security, Springer Nature, 2021, pp. 3–36.
conference:
end_date: 2021-03-05
location: Virtual
name: 'FC: Financial Cryptography'
start_date: 2021-03-01
date_created: 2021-11-21T23:01:29Z
date_published: 2021-10-23T00:00:00Z
date_updated: 2023-08-14T12:59:26Z
day: '23'
department:
- _id: ElKo
doi: 10.1007/978-3-662-64331-0_1
external_id:
isi:
- '000712016200001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2019/1128
month: '10'
oa: 1
oa_version: Preprint
page: 3-36
publication: 25th International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- 978-3-662-64331-0
eissn:
- 1611-3349
isbn:
- 9-783-6626-4330-3
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'SoK: Communication across distributed ledgers'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: '12675 '
year: '2021'
...
---
OA_place: repository
OA_type: green
_id: '10326'
abstract:
- lang: eng
text: Strigolactones (SLs) are carotenoid-derived plant hormones that control shoot
branching and communications between host plants and symbiotic fungi or root parasitic
plants. Extensive studies have identified the key components participating in
SL biosynthesis and signalling, whereas the catabolism or deactivation of endogenous
SLs in planta remains largely unknown. Here, we report that the Arabidopsis carboxylesterase
15 (AtCXE15) and its orthologues function as efficient hydrolases of SLs. We show
that overexpression of AtCXE15 promotes shoot branching by dampening SL-inhibited
axillary bud outgrowth. We further demonstrate that AtCXE15 could bind and efficiently
hydrolyse SLs both in vitro and in planta. We also provide evidence that AtCXE15
is capable of catalysing hydrolysis of diverse SL analogues and that such CXE15-dependent
catabolism of SLs is evolutionarily conserved in seed plants. These results disclose
a catalytic mechanism underlying homoeostatic regulation of SLs in plants, which
also provides a rational approach to spatial-temporally manipulate the endogenous
SLs and thus architecture of crops and ornamental plants.
acknowledgement: We thank J. Li (Institute of Genetics and Developmental Biology,
China) for providing the at14-1, atmax2-1, atmax3-9, atmax4-1, atmax1-1, kai2-2
(Col-0 background) mutants and B. Xu for providing the complementary DNA of P. patens.
We are grateful to L. Wang for assistance with MST, B. Han for assistance with UPLC–MS,
J. Li for assistance with confocal microscopy and B. Mikael and J. Zhang for their
comments on the manuscript. This work was supported by grants from Strategic Priority
Research Program of Chinese Academy of Sciences (Y.H., XDB27030102) and the National
Natural Science Foundation of China (E.X., 31700253; Y.H., 31830055).
article_processing_charge: No
article_type: original
author:
- first_name: Enjun
full_name: Xu, Enjun
last_name: Xu
- first_name: Liang
full_name: Chai, Liang
last_name: Chai
- first_name: Shiqi
full_name: Zhang, Shiqi
last_name: Zhang
- first_name: Ruixue
full_name: Yu, Ruixue
last_name: Yu
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Chongyi
full_name: Xu, Chongyi
last_name: Xu
- first_name: Yuxin
full_name: Hu, Yuxin
last_name: Hu
citation:
ama: Xu E, Chai L, Zhang S, et al. Catabolism of strigolactones by a carboxylesterase.
Nature Plants. 2021;7:1495–1504. doi:10.1038/s41477-021-01011-y
apa: Xu, E., Chai, L., Zhang, S., Yu, R., Zhang, X., Xu, C., & Hu, Y. (2021).
Catabolism of strigolactones by a carboxylesterase. Nature Plants. Springer
Nature. https://doi.org/10.1038/s41477-021-01011-y
chicago: Xu, Enjun, Liang Chai, Shiqi Zhang, Ruixue Yu, Xixi Zhang, Chongyi Xu,
and Yuxin Hu. “Catabolism of Strigolactones by a Carboxylesterase.” Nature
Plants. Springer Nature, 2021. https://doi.org/10.1038/s41477-021-01011-y.
ieee: E. Xu et al., “Catabolism of strigolactones by a carboxylesterase,”
Nature Plants, vol. 7. Springer Nature, pp. 1495–1504, 2021.
ista: Xu E, Chai L, Zhang S, Yu R, Zhang X, Xu C, Hu Y. 2021. Catabolism of strigolactones
by a carboxylesterase. Nature Plants. 7, 1495–1504.
mla: Xu, Enjun, et al. “Catabolism of Strigolactones by a Carboxylesterase.” Nature
Plants, vol. 7, Springer Nature, 2021, pp. 1495–1504, doi:10.1038/s41477-021-01011-y.
short: E. Xu, L. Chai, S. Zhang, R. Yu, X. Zhang, C. Xu, Y. Hu, Nature Plants 7
(2021) 1495–1504.
date_created: 2021-11-21T23:01:30Z
date_published: 2021-11-11T00:00:00Z
date_updated: 2025-01-21T12:42:52Z
day: '11'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41477-021-01011-y
external_id:
isi:
- '000717408000002'
pmid:
- '34764442'
file:
- access_level: open_access
checksum: d20231806bea67f0fd19e96a94a048f4
content_type: application/pdf
creator: dernst
date_created: 2025-01-21T12:41:43Z
date_updated: 2025-01-21T12:41:43Z
file_id: '18864'
file_name: Accepted version_Xu et al.,2021 Catabolism of strigolactones by a carboxylesterase.pdf
file_size: 41109943
relation: main_file
success: 1
file_date_updated: 2025-01-21T12:41:43Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: '1495–1504 '
pmid: 1
publication: Nature Plants
publication_identifier:
eissn:
- 2055-0278
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Catabolism of strigolactones by a carboxylesterase
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2021'
...
---
_id: '10327'
abstract:
- lang: eng
text: Composite materials offer numerous advantages in a wide range of applications,
including thermoelectrics. Here, semiconductor–metal composites are produced by
just blending nanoparticles of a sulfide semiconductor obtained in aqueous solution
and at room temperature with a metallic Cu powder. The obtained blend is annealed
in a reducing atmosphere and afterward consolidated into dense polycrystalline
pellets through spark plasma sintering (SPS). We observe that, during the annealing
process, the presence of metallic copper activates a partial reduction of the
PbS, resulting in the formation of PbS–Pb–CuxS composites. The presence of metallic
lead during the SPS process habilitates the liquid-phase sintering of the composite.
Besides, by comparing the transport properties of PbS, the PbS–Pb–CuxS composites,
and PbS–CuxS composites obtained by blending PbS and CuxS nanoparticles, we demonstrate
that the presence of metallic lead decisively contributes to a strong increase
of the charge carrier concentration through spillover of charge carriers enabled
by the low work function of lead. The increase in charge carrier concentration
translates into much higher electrical conductivities and moderately lower Seebeck
coefficients. These properties translate into power factors up to 2.1 mW m–1 K–2
at ambient temperature, well above those of PbS and PbS + CuxS. Additionally,
the presence of multiple phases in the final composite results in a notable decrease
in the lattice thermal conductivity. Overall, the introduction of metallic copper
in the initial blend results in a significant improvement of the thermoelectric
performance of PbS, reaching a dimensionless thermoelectric figure of merit ZT
= 1.1 at 750 K, which represents about a 400% increase over bare PbS. Besides,
an average ZTave = 0.72 in the temperature range 320–773 K is demonstrated.
acknowledgement: This work was supported by the European Regional Development Funds.
M.L., Y.Z., X.H., and K.X. thank the China Scholarship Council for scholarship support.
M. I. has been financially supported by IST Austria and the Werner Siemens Foundation.
Y.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation
program under the Marie Sklodowska-Curie grant agreement No. 754411. J.L. is a Serra
Húnter fellow and is grateful to ICREA Academia program and projects MICINN/FEDER
RTI2018-093996-B-C31 and GC 2017 SGR 128. ICN2 acknowledges funding from Generalitat
de Catalunya 2017 SGR 327 and the Spanish MINECO project NANOGEN (PID2020-116093RB-C43).
ICN2 was supported by the Severo Ochoa program from Spanish MINECO (grant no. SEV-2017-0706)
and was funded by the CERCA Programme/Generalitat de Catalunya. X.H. thanks China
Scholarship Council for scholarship support (201804910551). Part of the present
work was performed in the framework of Universitat Autònoma de Barcelona Materials
Science Ph.D. program.
article_processing_charge: No
article_type: original
author:
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Xu
full_name: Han, Xu
last_name: Han
- first_name: Ke
full_name: Xiao, Ke
last_name: Xiao
- first_name: Mehran
full_name: Nabahat, Mehran
last_name: Nabahat
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Jordi
full_name: Llorca, Jordi
last_name: Llorca
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Li M, Liu Y, Zhang Y, et al. PbS–Pb–CuxS composites for thermoelectric application.
ACS Applied Materials and Interfaces. 2021;13(43):51373–51382. doi:10.1021/acsami.1c15609
apa: Li, M., Liu, Y., Zhang, Y., Han, X., Xiao, K., Nabahat, M., … Cabot, A. (2021).
PbS–Pb–CuxS composites for thermoelectric application. ACS Applied Materials
and Interfaces. American Chemical Society . https://doi.org/10.1021/acsami.1c15609
chicago: Li, Mengyao, Yu Liu, Yu Zhang, Xu Han, Ke Xiao, Mehran Nabahat, Jordi Arbiol,
Jordi Llorca, Maria Ibáñez, and Andreu Cabot. “PbS–Pb–CuxS Composites for Thermoelectric
Application.” ACS Applied Materials and Interfaces. American Chemical Society
, 2021. https://doi.org/10.1021/acsami.1c15609.
ieee: M. Li et al., “PbS–Pb–CuxS composites for thermoelectric application,”
ACS Applied Materials and Interfaces, vol. 13, no. 43. American Chemical
Society , pp. 51373–51382, 2021.
ista: Li M, Liu Y, Zhang Y, Han X, Xiao K, Nabahat M, Arbiol J, Llorca J, Ibáñez
M, Cabot A. 2021. PbS–Pb–CuxS composites for thermoelectric application. ACS Applied
Materials and Interfaces. 13(43), 51373–51382.
mla: Li, Mengyao, et al. “PbS–Pb–CuxS Composites for Thermoelectric Application.”
ACS Applied Materials and Interfaces, vol. 13, no. 43, American Chemical
Society , 2021, pp. 51373–51382, doi:10.1021/acsami.1c15609.
short: M. Li, Y. Liu, Y. Zhang, X. Han, K. Xiao, M. Nabahat, J. Arbiol, J. Llorca,
M. Ibáñez, A. Cabot, ACS Applied Materials and Interfaces 13 (2021) 51373–51382.
corr_author: '1'
date_created: 2021-11-21T23:01:30Z
date_published: 2021-10-19T00:00:00Z
date_updated: 2025-04-14T07:43:47Z
day: '19'
department:
- _id: MaIb
doi: 10.1021/acsami.1c15609
ec_funded: 1
external_id:
isi:
- '000715852100070'
pmid:
- '34665616'
intvolume: ' 13'
isi: 1
issue: '43'
keyword:
- CuxS
- PbS
- energy conversion
- nanocomposite
- nanoparticle
- solution synthesis
- thermoelectric
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://upcommons.upc.edu/bitstream/2117/363528/1/Pb%20mengyao.pdf
month: '10'
oa: 1
oa_version: Submitted Version
page: 51373–51382
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: ACS Applied Materials and Interfaces
publication_identifier:
eissn:
- 1944-8252
issn:
- 1944-8244
publication_status: published
publisher: 'American Chemical Society '
quality_controlled: '1'
scopus_import: '1'
status: public
title: PbS–Pb–CuxS composites for thermoelectric application
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2021'
...
---
_id: '10363'
abstract:
- lang: eng
text: Erythropoietin enhances oxygen delivery and reduces hypoxia-induced cell death,
but its pro-thrombotic activity is problematic for use of erythropoietin in treating
hypoxia. We constructed a fusion protein that stimulates red blood cell production
and neuroprotection without triggering platelet production, a marker for thrombosis.
The protein consists of an anti-glycophorin A nanobody and an erythropoietin mutant
(L108A). The mutation reduces activation of erythropoietin receptor homodimers
that induce erythropoiesis and thrombosis, but maintains the tissue-protective
signaling. The binding of the nanobody element to glycophorin A rescues homodimeric
erythropoietin receptor activation on red blood cell precursors. In a cell proliferation
assay, the fusion protein is active at 10−14 M, allowing an estimate of the number
of receptor–ligand complexes needed for signaling. This fusion protein stimulates
erythroid cell proliferation in vitro and in mice, and shows neuroprotective activity
in vitro. Our erythropoietin fusion protein presents a novel molecule for treating
hypoxia.
acknowledgement: This work was supported by funds from the Wyss Institute for Biologically
Inspired Engineering and the Boston Biomedical Innovation Center (Pilot Award 112475;
Drive Award U54HL119145). J.L., K.M.K., D.R.B., J.C.W. and P.A.S. were supported
by the Harvard Medical School Department of Systems Biology. J.C.W. was further
supported by the Harvard Medical School Laboratory of Systems Pharmacology. A.V.,
D.R.B. and P.A.S. were further supported by the Wyss Institute for Biologically
Inspired Engineering. N.G.G. was sponsored by the Army Research Office under Grant
Number W911NF-17-2-0092. The views and conclusions contained in this document are
those of the authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Office or the U.S. Government.
The U.S. Government is authorized to reproduce and distribute reprints for Government
purposes notwithstanding any copyright notation herein. We sincerely thank Amanda
Graveline and the Wyss Institute at Harvard for their scientific support.
article_number: gzab025
article_processing_charge: No
article_type: original
author:
- first_name: Jungmin
full_name: Lee, Jungmin
last_name: Lee
- first_name: Andyna
full_name: Vernet, Andyna
last_name: Vernet
- first_name: Nathalie
full_name: Gruber, Nathalie
id: 2C9C8316-AA17-11E9-B5C2-8BC2E5697425
last_name: Gruber
- first_name: Kasia M.
full_name: Kready, Kasia M.
last_name: Kready
- first_name: Devin R.
full_name: Burrill, Devin R.
last_name: Burrill
- first_name: Jeffrey C.
full_name: Way, Jeffrey C.
last_name: Way
- first_name: Pamela A.
full_name: Silver, Pamela A.
last_name: Silver
citation:
ama: Lee J, Vernet A, Gruber N, et al. Rational engineering of an erythropoietin
fusion protein to treat hypoxia. Protein Engineering, Design and Selection.
2021;34. doi:10.1093/protein/gzab025
apa: Lee, J., Vernet, A., Gruber, N., Kready, K. M., Burrill, D. R., Way, J. C.,
& Silver, P. A. (2021). Rational engineering of an erythropoietin fusion protein
to treat hypoxia. Protein Engineering, Design and Selection. Oxford University
Press. https://doi.org/10.1093/protein/gzab025
chicago: Lee, Jungmin, Andyna Vernet, Nathalie Gruber, Kasia M. Kready, Devin R.
Burrill, Jeffrey C. Way, and Pamela A. Silver. “Rational Engineering of an Erythropoietin
Fusion Protein to Treat Hypoxia.” Protein Engineering, Design and Selection.
Oxford University Press, 2021. https://doi.org/10.1093/protein/gzab025.
ieee: J. Lee et al., “Rational engineering of an erythropoietin fusion protein
to treat hypoxia,” Protein Engineering, Design and Selection, vol. 34.
Oxford University Press, 2021.
ista: Lee J, Vernet A, Gruber N, Kready KM, Burrill DR, Way JC, Silver PA. 2021.
Rational engineering of an erythropoietin fusion protein to treat hypoxia. Protein
Engineering, Design and Selection. 34, gzab025.
mla: Lee, Jungmin, et al. “Rational Engineering of an Erythropoietin Fusion Protein
to Treat Hypoxia.” Protein Engineering, Design and Selection, vol. 34,
gzab025, Oxford University Press, 2021, doi:10.1093/protein/gzab025.
short: J. Lee, A. Vernet, N. Gruber, K.M. Kready, D.R. Burrill, J.C. Way, P.A. Silver,
Protein Engineering, Design and Selection 34 (2021).
date_created: 2021-11-28T23:01:28Z
date_published: 2021-11-01T00:00:00Z
date_updated: 2023-08-14T13:01:38Z
day: '01'
department:
- _id: CaGu
doi: 10.1093/protein/gzab025
external_id:
isi:
- '000746596900001'
pmid:
- '34725710'
intvolume: ' 34'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/protein/gzab025
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Protein Engineering, Design and Selection
publication_identifier:
eissn:
- 1741-0134
issn:
- 1741-0126
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rational engineering of an erythropoietin fusion protein to treat hypoxia
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 34
year: '2021'
...
---
_id: '10365'
abstract:
- lang: eng
text: The early development of many organisms involves the folding of cell monolayers,
but this behaviour is difficult to reproduce in vitro; therefore, both mechanistic
causes and effects of local curvature remain unclear. Here we study epithelial
cell monolayers on corrugated hydrogels engineered into wavy patterns, examining
how concave and convex curvatures affect cellular and nuclear shape. We find that
substrate curvature affects monolayer thickness, which is larger in valleys than
crests. We show that this feature generically arises in a vertex model, leading
to the hypothesis that cells may sense curvature by modifying the thickness of
the tissue. We find that local curvature also affects nuclear morphology and positioning,
which we explain by extending the vertex model to take into account membrane–nucleus
interactions, encoding thickness modulation in changes to nuclear deformation
and position. We propose that curvature governs the spatial distribution of yes-associated
proteins via nuclear shape and density changes. We show that curvature also induces
significant variations in lamins, chromatin condensation and cell proliferation
rate in folded epithelial tissues. Together, this work identifies active cell
mechanics and nuclear mechanoadaptation as the key players of the mechanistic
regulation of epithelia to substrate curvature.
acknowledgement: S.G. acknowledges funding from FEDER Prostem Research Project no.
1510614 (Wallonia DG06), F.R.S.-FNRS Epiforce Research Project no. T.0092.21 and
Interreg MAT(T)ISSE project, which is financially supported by Interreg France-Wallonie-Vlaanderen
(Fonds Européen de Développement Régional, FEDER-ERDF). This project was supported
by the European Research Council under the European Union’s Horizon 2020 Research
and Innovation Programme grant agreement 851288 (to E.H.), and by the Austrian Science
Fund (FWF) (P 31639; to E.H.). L.R.M. acknowledges funding from the Agence National
de la Recherche (ANR), as part of the ‘Investments d’Avenir’ Programme (I-SITE ULNE/ANR-16-IDEX-0004
ULNE). This work benefited from ANR-10-EQPX-04-01 and FEDER 12001407 grants to F.L.
W.D.V. is supported by the Research Foundation Flanders (FWO 1516619N, FWO GOO5819N,
FWO I003420N, FWO IRI I000321N) and is member of the Research Excellence Consortium
µNEURO at the University of Antwerp. M.L. is financially supported by FRIA (F.R.S.-FNRS).
M.S. is a Senior Research Associate of the Fund for Scientific Research (F.R.S.-FNRS)
and acknowledges EOS grant no. 30650939 (PRECISION). Sketches in Figs. 1a and 5e
and Extended Data Fig. 9 were drawn by C. Levicek.
article_processing_charge: No
article_type: original
author:
- first_name: Marine
full_name: Luciano, Marine
last_name: Luciano
- first_name: Shi-lei
full_name: Xue, Shi-lei
id: 31D2C804-F248-11E8-B48F-1D18A9856A87
last_name: Xue
- first_name: Winnok H.
full_name: De Vos, Winnok H.
last_name: De Vos
- first_name: Lorena
full_name: Redondo-Morata, Lorena
last_name: Redondo-Morata
- first_name: Mathieu
full_name: Surin, Mathieu
last_name: Surin
- first_name: Frank
full_name: Lafont, Frank
last_name: Lafont
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Sylvain
full_name: Gabriele, Sylvain
last_name: Gabriele
citation:
ama: Luciano M, Xue S, De Vos WH, et al. Cell monolayers sense curvature by exploiting
active mechanics and nuclear mechanoadaptation. Nature Physics. 2021;17(12):1382–1390.
doi:10.1038/s41567-021-01374-1
apa: Luciano, M., Xue, S., De Vos, W. H., Redondo-Morata, L., Surin, M., Lafont,
F., … Gabriele, S. (2021). Cell monolayers sense curvature by exploiting active
mechanics and nuclear mechanoadaptation. Nature Physics. Springer Nature.
https://doi.org/10.1038/s41567-021-01374-1
chicago: Luciano, Marine, Shi-lei Xue, Winnok H. De Vos, Lorena Redondo-Morata,
Mathieu Surin, Frank Lafont, Edouard B Hannezo, and Sylvain Gabriele. “Cell Monolayers
Sense Curvature by Exploiting Active Mechanics and Nuclear Mechanoadaptation.”
Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-021-01374-1.
ieee: M. Luciano et al., “Cell monolayers sense curvature by exploiting active
mechanics and nuclear mechanoadaptation,” Nature Physics, vol. 17, no.
12. Springer Nature, pp. 1382–1390, 2021.
ista: Luciano M, Xue S, De Vos WH, Redondo-Morata L, Surin M, Lafont F, Hannezo
EB, Gabriele S. 2021. Cell monolayers sense curvature by exploiting active mechanics
and nuclear mechanoadaptation. Nature Physics. 17(12), 1382–1390.
mla: Luciano, Marine, et al. “Cell Monolayers Sense Curvature by Exploiting Active
Mechanics and Nuclear Mechanoadaptation.” Nature Physics, vol. 17, no.
12, Springer Nature, 2021, pp. 1382–1390, doi:10.1038/s41567-021-01374-1.
short: M. Luciano, S. Xue, W.H. De Vos, L. Redondo-Morata, M. Surin, F. Lafont,
E.B. Hannezo, S. Gabriele, Nature Physics 17 (2021) 1382–1390.
corr_author: '1'
date_created: 2021-11-28T23:01:29Z
date_published: 2021-11-18T00:00:00Z
date_updated: 2025-04-14T07:52:26Z
day: '18'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1038/s41567-021-01374-1
ec_funded: 1
external_id:
isi:
- '000720204300004'
file:
- access_level: open_access
checksum: 5d6d76750a71d7cb632bb15417c38ef7
content_type: application/pdf
creator: channezo
date_created: 2023-10-11T09:31:43Z
date_updated: 2023-10-11T09:31:43Z
file_id: '14420'
file_name: 50145_4_merged_1630498627.pdf
file_size: 40285498
relation: main_file
success: 1
file_date_updated: 2023-10-11T09:31:43Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '12'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 1382–1390
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/how-cells-feel-curvature/
scopus_import: '1'
status: public
title: Cell monolayers sense curvature by exploiting active mechanics and nuclear
mechanoadaptation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '10366'
article_number: '203758'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Ana Maria
full_name: Lennon, Ana Maria
last_name: Lennon
- first_name: Roberto
full_name: Mayor, Roberto
last_name: Mayor
- first_name: Guillaume
full_name: Salbreux, Guillaume
last_name: Salbreux
citation:
ama: 'Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. Special rebranding issue:
“Quantitative cell and developmental biology.” Cells and Development. 2021;168(12).
doi:10.1016/j.cdev.2021.203758'
apa: 'Heisenberg, C.-P. J., Lennon, A. M., Mayor, R., & Salbreux, G. (2021).
Special rebranding issue: “Quantitative cell and developmental biology.” Cells
and Development. Elsevier. https://doi.org/10.1016/j.cdev.2021.203758'
chicago: 'Heisenberg, Carl-Philipp J, Ana Maria Lennon, Roberto Mayor, and Guillaume
Salbreux. “Special Rebranding Issue: ‘Quantitative Cell and Developmental Biology.’”
Cells and Development. Elsevier, 2021. https://doi.org/10.1016/j.cdev.2021.203758.'
ieee: 'C.-P. J. Heisenberg, A. M. Lennon, R. Mayor, and G. Salbreux, “Special rebranding
issue: ‘Quantitative cell and developmental biology,’” Cells and Development,
vol. 168, no. 12. Elsevier, 2021.'
ista: 'Heisenberg C-PJ, Lennon AM, Mayor R, Salbreux G. 2021. Special rebranding
issue: “Quantitative cell and developmental biology”. Cells and Development. 168(12),
203758.'
mla: 'Heisenberg, Carl-Philipp J., et al. “Special Rebranding Issue: ‘Quantitative
Cell and Developmental Biology.’” Cells and Development, vol. 168, no.
12, 203758, Elsevier, 2021, doi:10.1016/j.cdev.2021.203758.'
short: C.-P.J. Heisenberg, A.M. Lennon, R. Mayor, G. Salbreux, Cells and Development
168 (2021).
corr_author: '1'
date_created: 2021-11-28T23:01:30Z
date_published: 2021-11-17T00:00:00Z
date_updated: 2024-10-09T21:01:13Z
day: '17'
department:
- _id: CaHe
doi: 10.1016/j.cdev.2021.203758
external_id:
isi:
- '000974771600028'
pmid:
- '34800748'
intvolume: ' 168'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cdev.2021.203758
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cells and Development
publication_identifier:
issn:
- 2667-2901
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Special rebranding issue: “Quantitative cell and developmental biology”'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 168
year: '2021'
...
---
_id: '10367'
abstract:
- lang: eng
text: How information is created, shared and consumed has changed rapidly in recent
decades, in part thanks to new social platforms and technologies on the web. With
ever-larger amounts of unstructured and limited labels, organizing and reconciling
information from different sources and modalities is a central challenge in machine
learning. This cutting-edge tutorial aims to introduce the multimodal entailment
task, which can be useful for detecting semantic alignments when a single modality
alone does not suffice for a whole content understanding. Starting with a brief
overview of natural language processing, computer vision, structured data and
neural graph learning, we lay the foundations for the multimodal sections to follow.
We then discuss recent multimodal learning literature covering visual, audio and
language streams, and explore case studies focusing on tasks which require fine-grained
understanding of visual and linguistic semantics question answering, veracity
and hatred classification. Finally, we introduce a new dataset for recognizing
multimodal entailment, exploring it in a hands-on collaborative section. Overall,
this tutorial gives an overview of multimodal learning, introduces a multimodal
entailment dataset, and encourages future research in the topic.
acknowledgement: "We would like to thank Abby Schantz, Abe Ittycheriah, Aliaksei Severyn,
Allan Heydon, Aly\r\nGrealish, Andrey Vlasov, Arkaitz Zubiaga, Ashwin Kakarla, Chen
Sun, Clayton Williams, Cong\r\nYu, Cordelia Schmid, Da-Cheng Juan, Dan Finnie, Dani
Valevski, Daniel Rocha, David Price, David Sklar, Devi Krishna, Elena Kochkina,
Enrique Alfonseca, Franc¸oise Beaufays, Isabelle Augenstein, Jialu Liu, John Cantwell,
John Palowitch, Jordan Boyd-Graber, Lei Shi, Luis Valente, Maria Voitovich, Mehmet
Aktuna, Mogan Brown, Mor Naaman, Natalia P, Nidhi Hebbar, Pete Aykroyd, Rahul Sukthankar,
Richa Dixit, Steve Pucci, Tania Bedrax-Weiss, Tobias Kaufmann, Tom Boulos, Tu Tsao,
Vladimir Chtchetkine, Yair Kurzion, Yifan Xu and Zach Hynes."
article_processing_charge: No
author:
- first_name: Cesar
full_name: Ilharco, Cesar
last_name: Ilharco
- first_name: Afsaneh
full_name: Shirazi, Afsaneh
last_name: Shirazi
- first_name: Arjun
full_name: Gopalan, Arjun
last_name: Gopalan
- first_name: Arsha
full_name: Nagrani, Arsha
last_name: Nagrani
- first_name: Blaž
full_name: Bratanič, Blaž
last_name: Bratanič
- first_name: Chris
full_name: Bregler, Chris
last_name: Bregler
- first_name: Christina
full_name: Liu, Christina
last_name: Liu
- first_name: Felipe
full_name: Ferreira, Felipe
last_name: Ferreira
- first_name: Gabriek
full_name: Barcik, Gabriek
last_name: Barcik
- first_name: Gabriel
full_name: Ilharco, Gabriel
last_name: Ilharco
- first_name: Georg F
full_name: Osang, Georg F
id: 464B40D6-F248-11E8-B48F-1D18A9856A87
last_name: Osang
- first_name: Jannis
full_name: Bulian, Jannis
last_name: Bulian
- first_name: Jared
full_name: Frank, Jared
last_name: Frank
- first_name: Lucas
full_name: Smaira, Lucas
last_name: Smaira
- first_name: Qin
full_name: Cao, Qin
last_name: Cao
- first_name: Ricardo
full_name: Marino, Ricardo
last_name: Marino
- first_name: Roma
full_name: Patel, Roma
last_name: Patel
- first_name: Thomas
full_name: Leung, Thomas
last_name: Leung
- first_name: Vaiva
full_name: Imbrasaite, Vaiva
last_name: Imbrasaite
citation:
ama: 'Ilharco C, Shirazi A, Gopalan A, et al. Recognizing multimodal entailment.
In: 59th Annual Meeting of the Association for Computational Linguistics and
the 11th International Joint Conference on Natural Language Processing, Tutorial
Abstracts. Association for Computational Linguistics; 2021:29-30. doi:10.18653/v1/2021.acl-tutorials.6'
apa: 'Ilharco, C., Shirazi, A., Gopalan, A., Nagrani, A., Bratanič, B., Bregler,
C., … Imbrasaite, V. (2021). Recognizing multimodal entailment. In 59th Annual
Meeting of the Association for Computational Linguistics and the 11th International
Joint Conference on Natural Language Processing, Tutorial Abstracts (pp. 29–30).
Bangkok, Thailand: Association for Computational Linguistics. https://doi.org/10.18653/v1/2021.acl-tutorials.6'
chicago: Ilharco, Cesar, Afsaneh Shirazi, Arjun Gopalan, Arsha Nagrani, Blaž Bratanič,
Chris Bregler, Christina Liu, et al. “Recognizing Multimodal Entailment.” In 59th
Annual Meeting of the Association for Computational Linguistics and the 11th International
Joint Conference on Natural Language Processing, Tutorial Abstracts, 29–30.
Association for Computational Linguistics, 2021. https://doi.org/10.18653/v1/2021.acl-tutorials.6.
ieee: C. Ilharco et al., “Recognizing multimodal entailment,” in 59th
Annual Meeting of the Association for Computational Linguistics and the 11th International
Joint Conference on Natural Language Processing, Tutorial Abstracts, Bangkok,
Thailand, 2021, pp. 29–30.
ista: 'Ilharco C, Shirazi A, Gopalan A, Nagrani A, Bratanič B, Bregler C, Liu C,
Ferreira F, Barcik G, Ilharco G, Osang GF, Bulian J, Frank J, Smaira L, Cao Q,
Marino R, Patel R, Leung T, Imbrasaite V. 2021. Recognizing multimodal entailment.
59th Annual Meeting of the Association for Computational Linguistics and the 11th
International Joint Conference on Natural Language Processing, Tutorial Abstracts.
ACL: Association for Computational Linguistics ; IJCNLP: International Joint Conference
on Natural Language Processing, 29–30.'
mla: Ilharco, Cesar, et al. “Recognizing Multimodal Entailment.” 59th Annual
Meeting of the Association for Computational Linguistics and the 11th International
Joint Conference on Natural Language Processing, Tutorial Abstracts, Association
for Computational Linguistics, 2021, pp. 29–30, doi:10.18653/v1/2021.acl-tutorials.6.
short: C. Ilharco, A. Shirazi, A. Gopalan, A. Nagrani, B. Bratanič, C. Bregler,
C. Liu, F. Ferreira, G. Barcik, G. Ilharco, G.F. Osang, J. Bulian, J. Frank, L.
Smaira, Q. Cao, R. Marino, R. Patel, T. Leung, V. Imbrasaite, in:, 59th Annual
Meeting of the Association for Computational Linguistics and the 11th International
Joint Conference on Natural Language Processing, Tutorial Abstracts, Association
for Computational Linguistics, 2021, pp. 29–30.
conference:
end_date: 2021-08-06
location: Bangkok, Thailand
name: 'ACL: Association for Computational Linguistics ; IJCNLP: International Joint
Conference on Natural Language Processing'
start_date: 2021-08-01
date_created: 2021-11-28T23:01:30Z
date_published: 2021-08-01T00:00:00Z
date_updated: 2022-01-26T14:26:36Z
day: '01'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.18653/v1/2021.acl-tutorials.6
file:
- access_level: open_access
checksum: b14052a025a6ecf675bdfe51db98c0d7
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date_created: 2021-11-29T08:41:00Z
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url: https://aclanthology.org/2021.acl-tutorials.6/
month: '08'
oa: 1
oa_version: Published Version
page: 29-30
publication: 59th Annual Meeting of the Association for Computational Linguistics
and the 11th International Joint Conference on Natural Language Processing, Tutorial
Abstracts
publication_identifier:
isbn:
- 9-781-9540-8557-2
publication_status: published
publisher: Association for Computational Linguistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Recognizing multimodal entailment
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10402'
abstract:
- lang: eng
text: Branching morphogenesis governs the formation of many organs such as lung,
kidney, and the neurovascular system. Many studies have explored system-specific
molecular and cellular regulatory mechanisms, as well as self-organizing rules
underlying branching morphogenesis. However, in addition to local cues, branched
tissue growth can also be influenced by global guidance. Here, we develop a theoretical
framework for a stochastic self-organized branching process in the presence of
external cues. Combining analytical theory with numerical simulations, we predict
differential signatures of global vs. local regulatory mechanisms on the branching
pattern, such as angle distributions, domain size, and space-filling efficiency.
We find that branch alignment follows a generic scaling law determined by the
strength of global guidance, while local interactions influence the tissue density
but not its overall territory. Finally, using zebrafish innervation as a model
system, we test these key features of the model experimentally. Our work thus
provides quantitative predictions to disentangle the role of different types of
cues in shaping branched structures across scales.
acknowledgement: We thank all members of our respective groups for helpful discussion
on the paper. The authors are also grateful to Prof. Abdel El. Manira for support
and sharing Tg(HUC:Gal4;UAS:Synaptohysin-GFP), to Haohao Wu for discussion, and
thank Elena Zabalueva for the zebrafish schematic. The authors also acknowledge
Zebrafish core facility, Genome Engineering Zebrafish and Biomedicum Imaging Core
from the Karolinska Institutet for technical support. This work received funding
from the ERC under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No. 851288 to E.H.) and under the Marie Skłodowska-Curie grant
agreement No. 754411 (to M.C.U.); Swedish Research Council (to F.L., I.A. and S.H.);
Knut and Alice Wallenberg Foundation (F.L. and I.A.); Swedish Brain Foundation (F.L.
and S.H.); Ming Wai Lau Foundation (to F.L.); StratRegen (to F.L.); ERC Consolidator
grant STEMMING-FROM-NERVE and ERC Synergy Grant KILL-OR-DIFFERENTIATE (to I.A.);
Bertil Hallsten Research Foundation (to I.A.); Cancerfonden (to I.A.); the Paradifference
Foundation (to I.A.); Austrian Science Fund (to I.A.); and StratNeuro (to S.H.).
article_number: '6830'
article_processing_charge: No
article_type: original
author:
- first_name: Mehmet C
full_name: Ucar, Mehmet C
id: 50B2A802-6007-11E9-A42B-EB23E6697425
last_name: Ucar
orcid: 0000-0003-0506-4217
- first_name: Dmitrii
full_name: Kamenev, Dmitrii
last_name: Kamenev
- first_name: Kazunori
full_name: Sunadome, Kazunori
last_name: Sunadome
- first_name: Dominik C
full_name: Fachet, Dominik C
id: 14FDD550-AA41-11E9-A0E5-1ACCE5697425
last_name: Fachet
- first_name: Francois
full_name: Lallemend, Francois
last_name: Lallemend
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
- first_name: Saida
full_name: Hadjab, Saida
last_name: Hadjab
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Ucar MC, Kamenev D, Sunadome K, et al. Theory of branching morphogenesis by
local interactions and global guidance. Nature Communications. 2021;12.
doi:10.1038/s41467-021-27135-5
apa: Ucar, M. C., Kamenev, D., Sunadome, K., Fachet, D. C., Lallemend, F., Adameyko,
I., … Hannezo, E. B. (2021). Theory of branching morphogenesis by local interactions
and global guidance. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-021-27135-5
chicago: Ucar, Mehmet C, Dmitrii Kamenev, Kazunori Sunadome, Dominik C Fachet, Francois
Lallemend, Igor Adameyko, Saida Hadjab, and Edouard B Hannezo. “Theory of Branching
Morphogenesis by Local Interactions and Global Guidance.” Nature Communications.
Springer Nature, 2021. https://doi.org/10.1038/s41467-021-27135-5.
ieee: M. C. Ucar et al., “Theory of branching morphogenesis by local interactions
and global guidance,” Nature Communications, vol. 12. Springer Nature,
2021.
ista: Ucar MC, Kamenev D, Sunadome K, Fachet DC, Lallemend F, Adameyko I, Hadjab
S, Hannezo EB. 2021. Theory of branching morphogenesis by local interactions and
global guidance. Nature Communications. 12, 6830.
mla: Ucar, Mehmet C., et al. “Theory of Branching Morphogenesis by Local Interactions
and Global Guidance.” Nature Communications, vol. 12, 6830, Springer Nature,
2021, doi:10.1038/s41467-021-27135-5.
short: M.C. Ucar, D. Kamenev, K. Sunadome, D.C. Fachet, F. Lallemend, I. Adameyko,
S. Hadjab, E.B. Hannezo, Nature Communications 12 (2021).
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-24T00:00:00Z
date_updated: 2025-04-14T07:43:47Z
day: '24'
ddc:
- '573'
department:
- _id: EdHa
doi: 10.1038/s41467-021-27135-5
ec_funded: 1
external_id:
isi:
- '000722322900020'
pmid:
- '34819507'
file:
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checksum: 63c56ec75314a71e63e7dd2920b3c5b5
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-10T08:54:09Z
date_updated: 2021-12-10T08:54:09Z
file_id: '10529'
file_name: 2021_NatComm_Ucar.pdf
file_size: 2303405
relation: main_file
success: 1
file_date_updated: 2021-12-10T08:54:09Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13058'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Theory of branching morphogenesis by local interactions and global guidance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '10403'
abstract:
- lang: eng
text: Synaptic transmission, connectivity, and dendritic morphology mature in parallel
during brain development and are often disrupted in neurodevelopmental disorders.
Yet how these changes influence the neuronal computations necessary for normal
brain function are not well understood. To identify cellular mechanisms underlying
the maturation of synaptic integration in interneurons, we combined patch-clamp
recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional
reconstruction of SC morphology with excitatory synapse location, and biophysical
modeling. We found that postnatal maturation of postsynaptic strength was homogeneously
reduced along the somatodendritic axis, but dendritic integration was always sublinear.
However, dendritic branching increased without changes in synapse density, leading
to a substantial gain in distal inputs. Thus, changes in synapse distribution,
rather than dendrite cable properties, are the dominant mechanism underlying the
maturation of neuronal computation. These mechanisms favor the emergence of a
spatially compartmentalized two-stage integration model promoting location-dependent
integration within dendritic subunits.
acknowledgement: This study was supported by the Centre National de la Recherche Scientifique
and the Agence Nationale de la Recherche (ANR-13-BSV4-00166, to LC and DAD). TA
was supported by fellowships from the Fondation pour la Recherche Medicale and the
Swedish Research Council. We thank Dmitry Ershov from the Image Analysis Hub of
the Institut Pasteur, Elodie Le Monnier, Elena Hollergschwandtner, Vanessa Zheden,
and Corinne Nantet for technical support and Haining Zhong for providing the Venus-tagged
PSD95 mouse line. We would like to thank Alberto Bacci, Ann Lohof, and Nelson Rebola
for comments on the manuscript.
article_number: e65954
article_processing_charge: No
article_type: original
author:
- first_name: Celia
full_name: Biane, Celia
last_name: Biane
- first_name: Florian
full_name: Rückerl, Florian
last_name: Rückerl
- first_name: Therese
full_name: Abrahamsson, Therese
last_name: Abrahamsson
- first_name: Cécile
full_name: Saint-Cloment, Cécile
last_name: Saint-Cloment
- first_name: Jean
full_name: Mariani, Jean
last_name: Mariani
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: David A.
full_name: Digregorio, David A.
last_name: Digregorio
- first_name: Rachel M.
full_name: Sherrard, Rachel M.
last_name: Sherrard
- first_name: Laurence
full_name: Cathala, Laurence
last_name: Cathala
citation:
ama: Biane C, Rückerl F, Abrahamsson T, et al. Developmental emergence of two-stage
nonlinear synaptic integration in cerebellar interneurons. eLife. 2021;10.
doi:10.7554/eLife.65954
apa: Biane, C., Rückerl, F., Abrahamsson, T., Saint-Cloment, C., Mariani, J., Shigemoto,
R., … Cathala, L. (2021). Developmental emergence of two-stage nonlinear synaptic
integration in cerebellar interneurons. ELife. eLife Sciences Publications.
https://doi.org/10.7554/eLife.65954
chicago: Biane, Celia, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment,
Jean Mariani, Ryuichi Shigemoto, David A. Digregorio, Rachel M. Sherrard, and
Laurence Cathala. “Developmental Emergence of Two-Stage Nonlinear Synaptic Integration
in Cerebellar Interneurons.” ELife. eLife Sciences Publications, 2021.
https://doi.org/10.7554/eLife.65954.
ieee: C. Biane et al., “Developmental emergence of two-stage nonlinear synaptic
integration in cerebellar interneurons,” eLife, vol. 10. eLife Sciences
Publications, 2021.
ista: Biane C, Rückerl F, Abrahamsson T, Saint-Cloment C, Mariani J, Shigemoto R,
Digregorio DA, Sherrard RM, Cathala L. 2021. Developmental emergence of two-stage
nonlinear synaptic integration in cerebellar interneurons. eLife. 10, e65954.
mla: Biane, Celia, et al. “Developmental Emergence of Two-Stage Nonlinear Synaptic
Integration in Cerebellar Interneurons.” ELife, vol. 10, e65954, eLife
Sciences Publications, 2021, doi:10.7554/eLife.65954.
short: C. Biane, F. Rückerl, T. Abrahamsson, C. Saint-Cloment, J. Mariani, R. Shigemoto,
D.A. Digregorio, R.M. Sherrard, L. Cathala, ELife 10 (2021).
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-03T00:00:00Z
date_updated: 2025-03-07T08:12:39Z
day: '03'
ddc:
- '570'
department:
- _id: RySh
doi: 10.7554/eLife.65954
external_id:
isi:
- '000715789500001'
pmid:
- '34730085'
file:
- access_level: open_access
checksum: c7c33c3319428d56e332e22349c50ed3
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-10T08:31:41Z
date_updated: 2021-12-10T08:31:41Z
file_id: '10528'
file_name: 2021_eLife_Biane.pdf
file_size: 13131322
relation: main_file
success: 1
file_date_updated: 2021-12-10T08:31:41Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental emergence of two-stage nonlinear synaptic integration in cerebellar
interneurons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2021'
...
---
_id: '10404'
abstract:
- lang: eng
text: While convolutional neural networks (CNNs) have found wide adoption as state-of-the-art
models for image-related tasks, their predictions are often highly sensitive to
small input perturbations, which the human vision is robust against. This paper
presents Perturber, a web-based application that allows users to instantaneously
explore how CNN activations and predictions evolve when a 3D input scene is interactively
perturbed. Perturber offers a large variety of scene modifications, such as camera
controls, lighting and shading effects, background modifications, object morphing,
as well as adversarial attacks, to facilitate the discovery of potential vulnerabilities.
Fine-tuned model versions can be directly compared for qualitative evaluation
of their robustness. Case studies with machine learning experts have shown that
Perturber helps users to quickly generate hypotheses about model vulnerabilities
and to qualitatively compare model behavior. Using quantitative analyses, we could
replicate users’ insights with other CNN architectures and input images, yielding
new insights about the vulnerability of adversarially trained models.
acknowledgement: "We thank Robert Geirhos and Roland Zimmermann for their participation
in the case study and valuable feedback, Chris Olah and Nick Cammarata for valuable
discussions in the early phase of the project, as well as the Distill Slack workspace
as a platform for discussions. M.L. is supported in part by the Austrian Science
Fund (FWF) under grant Z211-N23 (Wittgenstein Award). J.B. is supported by the German
Federal Ministry of Education and Research\r\n(BMBF) through the Competence Center
for Machine Learning (TUE.AI, FKZ 01IS18039A) and the International Max Planck Research
School for Intelligent Systems (IMPRS-IS). R.H. is partially supported by Boeing
and Horizon-2020 ECSEL (grant 783163, iDev40).\r\n"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Stefan
full_name: Sietzen, Stefan
last_name: Sietzen
- first_name: Mathias
full_name: Lechner, Mathias
id: 3DC22916-F248-11E8-B48F-1D18A9856A87
last_name: Lechner
- first_name: Judy
full_name: Borowski, Judy
last_name: Borowski
- first_name: Ramin
full_name: Hasani, Ramin
last_name: Hasani
- first_name: Manuela
full_name: Waldner, Manuela
last_name: Waldner
citation:
ama: Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. Interactive analysis
of CNN robustness. Computer Graphics Forum. 2021;40(7):253-264. doi:10.1111/cgf.14418
apa: Sietzen, S., Lechner, M., Borowski, J., Hasani, R., & Waldner, M. (2021).
Interactive analysis of CNN robustness. Computer Graphics Forum. Wiley.
https://doi.org/10.1111/cgf.14418
chicago: Sietzen, Stefan, Mathias Lechner, Judy Borowski, Ramin Hasani, and Manuela
Waldner. “Interactive Analysis of CNN Robustness.” Computer Graphics Forum.
Wiley, 2021. https://doi.org/10.1111/cgf.14418.
ieee: S. Sietzen, M. Lechner, J. Borowski, R. Hasani, and M. Waldner, “Interactive
analysis of CNN robustness,” Computer Graphics Forum, vol. 40, no. 7. Wiley,
pp. 253–264, 2021.
ista: Sietzen S, Lechner M, Borowski J, Hasani R, Waldner M. 2021. Interactive analysis
of CNN robustness. Computer Graphics Forum. 40(7), 253–264.
mla: Sietzen, Stefan, et al. “Interactive Analysis of CNN Robustness.” Computer
Graphics Forum, vol. 40, no. 7, Wiley, 2021, pp. 253–64, doi:10.1111/cgf.14418.
short: S. Sietzen, M. Lechner, J. Borowski, R. Hasani, M. Waldner, Computer Graphics
Forum 40 (2021) 253–264.
date_created: 2021-12-05T23:01:40Z
date_published: 2021-11-27T00:00:00Z
date_updated: 2025-04-15T06:25:55Z
day: '27'
department:
- _id: ToHe
doi: 10.1111/cgf.14418
external_id:
arxiv:
- '2110.07667'
isi:
- '000722952000024'
intvolume: ' 40'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2110.07667
month: '11'
oa: 1
oa_version: Preprint
page: 253-264
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactive analysis of CNN robustness
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 40
year: '2021'
...