---
_id: '8253'
abstract:
- lang: eng
text: Brains process information in spiking neural networks. Their intricate connections
shape the diverse functions these networks perform. In comparison, the functional
capabilities of models of spiking networks are still rudimentary. This shortcoming
is mainly due to the lack of insight and practical algorithms to construct the
necessary connectivity. Any such algorithm typically attempts to build networks
by iteratively reducing the error compared to a desired output. But assigning
credit to hidden units in multi-layered spiking networks has remained challenging
due to the non-differentiable nonlinearity of spikes. To avoid this issue, one
can employ surrogate gradients to discover the required connectivity in spiking
network models. However, the choice of a surrogate is not unique, raising the
question of how its implementation influences the effectiveness of the method.
Here, we use numerical simulations to systematically study how essential design
parameters of surrogate gradients impact learning performance on a range of classification
problems. We show that surrogate gradient learning is robust to different shapes
of underlying surrogate derivatives, but the choice of the derivative’s scale
can substantially affect learning performance. When we combine surrogate gradients
with a suitable activity regularization technique, robust information processing
can be achieved in spiking networks even at the sparse activity limit. Our study
provides a systematic account of the remarkable robustness of surrogate gradient
learning and serves as a practical guide to model functional spiking neural networks.
acknowledgement: F.Z. was supported by the Wellcome Trust (110124/Z/15/Z) and the
Novartis Research Foundation. T.P.V. was supported by a Wellcome Trust Sir Henry
Dale Research fellowship (WT100000), a Wellcome Trust Senior Research Fellowship
(214316/Z/18/Z), and an ERC Consolidator Grant SYNAPSEEK.
article_processing_charge: No
article_type: original
author:
- first_name: Friedemann
full_name: Zenke, Friedemann
last_name: Zenke
orcid: 0000-0003-1883-644X
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Zenke F, Vogels TP. The remarkable robustness of surrogate gradient learning
for instilling complex function in spiking neural networks. Neural Computation.
2021;33(4):899-925. doi:10.1162/neco_a_01367
apa: Zenke, F., & Vogels, T. P. (2021). The remarkable robustness of surrogate
gradient learning for instilling complex function in spiking neural networks.
Neural Computation. MIT Press. https://doi.org/10.1162/neco_a_01367
chicago: Zenke, Friedemann, and Tim P Vogels. “The Remarkable Robustness of Surrogate
Gradient Learning for Instilling Complex Function in Spiking Neural Networks.”
Neural Computation. MIT Press, 2021. https://doi.org/10.1162/neco_a_01367.
ieee: F. Zenke and T. P. Vogels, “The remarkable robustness of surrogate gradient
learning for instilling complex function in spiking neural networks,” Neural
Computation, vol. 33, no. 4. MIT Press, pp. 899–925, 2021.
ista: Zenke F, Vogels TP. 2021. The remarkable robustness of surrogate gradient
learning for instilling complex function in spiking neural networks. Neural Computation.
33(4), 899–925.
mla: Zenke, Friedemann, and Tim P. Vogels. “The Remarkable Robustness of Surrogate
Gradient Learning for Instilling Complex Function in Spiking Neural Networks.”
Neural Computation, vol. 33, no. 4, MIT Press, 2021, pp. 899–925, doi:10.1162/neco_a_01367.
short: F. Zenke, T.P. Vogels, Neural Computation 33 (2021) 899–925.
corr_author: '1'
date_created: 2020-08-12T12:08:24Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2025-04-14T09:44:14Z
day: '01'
ddc:
- '000'
- '570'
department:
- _id: TiVo
doi: 10.1162/neco_a_01367
ec_funded: 1
external_id:
isi:
- '000663433900003'
pmid:
- '33513328'
file:
- access_level: open_access
checksum: eac5a51c24c8989ae7cf9ae32ec3bc95
content_type: application/pdf
creator: dernst
date_created: 2022-04-08T06:05:39Z
date_updated: 2022-04-08T06:05:39Z
file_id: '11131'
file_name: 2021_NeuralComputation_Zenke.pdf
file_size: 1611614
relation: main_file
success: 1
file_date_updated: 2022-04-08T06:05:39Z
has_accepted_license: '1'
intvolume: ' 33'
isi: 1
issue: '4'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 899-925
pmid: 1
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
call_identifier: H2020
grant_number: '819603'
name: Learning the shape of synaptic plasticity rules for neuronal architectures
and function through machine learning.
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
grant_number: 214316/Z/18/Z
name: "Whatâ\x80\x99s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
neuronal networks."
publication: Neural Computation
publication_identifier:
eissn:
- 1530-888X
issn:
- 0899-7667
publication_status: published
publisher: MIT Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The remarkable robustness of surrogate gradient learning for instilling complex
function in spiking neural networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 33
year: '2021'
...
---
_id: '8338'
abstract:
- lang: eng
text: Canonical parametrisations of classical confocal coordinate systems are introduced
and exploited to construct non-planar analogues of incircular (IC) nets on individual
quadrics and systems of confocal quadrics. Intimate connections with classical
deformations of quadrics that are isometric along asymptotic lines and circular
cross-sections of quadrics are revealed. The existence of octahedral webs of surfaces
of Blaschke type generated by asymptotic and characteristic lines that are diagonally
related to lines of curvature is proved theoretically and established constructively.
Appropriate samplings (grids) of these webs lead to three-dimensional extensions
of non-planar IC nets. Three-dimensional octahedral grids composed of planes and
spatially extending (checkerboard) IC-nets are shown to arise in connection with
systems of confocal quadrics in Minkowski space. In this context, the Laguerre
geometric notion of conical octahedral grids of planes is introduced. The latter
generalise the octahedral grids derived from systems of confocal quadrics in Minkowski
space. An explicit construction of conical octahedral grids is presented. The
results are accompanied by various illustrations which are based on the explicit
formulae provided by the theory.
acknowledgement: This research was supported by the DFG Collaborative Research Center
TRR 109 “Discretization in Geometry and Dynamics”. W.K.S. was also supported by
the Australian Research Council (DP1401000851). A.V.A. was also supported by the
European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme (Grant Agreement No. 78818 Alpha).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Arseniy
full_name: Akopyan, Arseniy
id: 430D2C90-F248-11E8-B48F-1D18A9856A87
last_name: Akopyan
orcid: 0000-0002-2548-617X
- first_name: Alexander I.
full_name: Bobenko, Alexander I.
last_name: Bobenko
- first_name: Wolfgang K.
full_name: Schief, Wolfgang K.
last_name: Schief
- first_name: Jan
full_name: Techter, Jan
last_name: Techter
citation:
ama: Akopyan A, Bobenko AI, Schief WK, Techter J. On mutually diagonal nets on (confocal)
quadrics and 3-dimensional webs. Discrete and Computational Geometry. 2021;66:938-976.
doi:10.1007/s00454-020-00240-w
apa: Akopyan, A., Bobenko, A. I., Schief, W. K., & Techter, J. (2021). On mutually
diagonal nets on (confocal) quadrics and 3-dimensional webs. Discrete and Computational
Geometry. Springer Nature. https://doi.org/10.1007/s00454-020-00240-w
chicago: Akopyan, Arseniy, Alexander I. Bobenko, Wolfgang K. Schief, and Jan Techter.
“On Mutually Diagonal Nets on (Confocal) Quadrics and 3-Dimensional Webs.” Discrete
and Computational Geometry. Springer Nature, 2021. https://doi.org/10.1007/s00454-020-00240-w.
ieee: A. Akopyan, A. I. Bobenko, W. K. Schief, and J. Techter, “On mutually diagonal
nets on (confocal) quadrics and 3-dimensional webs,” Discrete and Computational
Geometry, vol. 66. Springer Nature, pp. 938–976, 2021.
ista: Akopyan A, Bobenko AI, Schief WK, Techter J. 2021. On mutually diagonal nets
on (confocal) quadrics and 3-dimensional webs. Discrete and Computational Geometry.
66, 938–976.
mla: Akopyan, Arseniy, et al. “On Mutually Diagonal Nets on (Confocal) Quadrics
and 3-Dimensional Webs.” Discrete and Computational Geometry, vol. 66,
Springer Nature, 2021, pp. 938–76, doi:10.1007/s00454-020-00240-w.
short: A. Akopyan, A.I. Bobenko, W.K. Schief, J. Techter, Discrete and Computational
Geometry 66 (2021) 938–976.
date_created: 2020-09-06T22:01:13Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2025-04-14T07:48:36Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/s00454-020-00240-w
ec_funded: 1
external_id:
arxiv:
- '1908.00856'
isi:
- '000564488500002'
intvolume: ' 66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1908.00856
month: '10'
oa: 1
oa_version: Preprint
page: 938-976
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On mutually diagonal nets on (confocal) quadrics and 3-dimensional webs
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2021'
...
---
_id: '8373'
abstract:
- lang: eng
text: It is well known that special Kubo-Ando operator means admit divergence center
interpretations, moreover, they are also mean squared error estimators for certain
metrics on positive definite operators. In this paper we give a divergence center
interpretation for every symmetric Kubo-Ando mean. This characterization of the
symmetric means naturally leads to a definition of weighted and multivariate versions
of a large class of symmetric Kubo-Ando means. We study elementary properties
of these weighted multivariate means, and note in particular that in the special
case of the geometric mean we recover the weighted A#H-mean introduced by Kim,
Lawson, and Lim.
acknowledgement: "The authors are grateful to Milán Mosonyi for fruitful discussions
on the topic, and to the anonymous referee for his/her comments and suggestions.\r\nJ.
Pitrik was supported by the Hungarian Academy of Sciences Lendület-Momentum Grant
for Quantum Information Theory, No. 96 141, and by Hungarian National Research,
Development and Innovation Office (NKFIH) via grants no. K119442, no. K124152, and
no. KH129601. D. Virosztek was supported by the ISTFELLOW program of the Institute
of Science and Technology Austria (project code IC1027FELL01), by the European Union's
Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant
Agreement No. 846294, and partially supported by the Hungarian National Research,
Development and Innovation Office (NKFIH) via grants no. K124152, and no. KH129601."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: József
full_name: Pitrik, József
last_name: Pitrik
- first_name: Daniel
full_name: Virosztek, Daniel
id: 48DB45DA-F248-11E8-B48F-1D18A9856A87
last_name: Virosztek
orcid: 0000-0003-1109-5511
citation:
ama: Pitrik J, Virosztek D. A divergence center interpretation of general symmetric
Kubo-Ando means, and related weighted multivariate operator means. Linear Algebra
and its Applications. 2021;609:203-217. doi:10.1016/j.laa.2020.09.007
apa: Pitrik, J., & Virosztek, D. (2021). A divergence center interpretation
of general symmetric Kubo-Ando means, and related weighted multivariate operator
means. Linear Algebra and Its Applications. Elsevier. https://doi.org/10.1016/j.laa.2020.09.007
chicago: Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation
of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator
Means.” Linear Algebra and Its Applications. Elsevier, 2021. https://doi.org/10.1016/j.laa.2020.09.007.
ieee: J. Pitrik and D. Virosztek, “A divergence center interpretation of general
symmetric Kubo-Ando means, and related weighted multivariate operator means,”
Linear Algebra and its Applications, vol. 609. Elsevier, pp. 203–217, 2021.
ista: Pitrik J, Virosztek D. 2021. A divergence center interpretation of general
symmetric Kubo-Ando means, and related weighted multivariate operator means. Linear
Algebra and its Applications. 609, 203–217.
mla: Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of
General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator
Means.” Linear Algebra and Its Applications, vol. 609, Elsevier, 2021,
pp. 203–17, doi:10.1016/j.laa.2020.09.007.
short: J. Pitrik, D. Virosztek, Linear Algebra and Its Applications 609 (2021) 203–217.
date_created: 2020-09-11T08:35:50Z
date_published: 2021-01-15T00:00:00Z
date_updated: 2025-04-14T07:50:40Z
day: '15'
department:
- _id: LaEr
doi: 10.1016/j.laa.2020.09.007
ec_funded: 1
external_id:
arxiv:
- '2002.11678'
isi:
- '000581730500011'
intvolume: ' 609'
isi: 1
keyword:
- Kubo-Ando mean
- weighted multivariate mean
- barycenter
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.11678
month: '01'
oa: 1
oa_version: Preprint
page: 203-217
project:
- _id: 26A455A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '846294'
name: Geometric study of Wasserstein spaces and free probability
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Linear Algebra and its Applications
publication_identifier:
issn:
- 0024-3795
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A divergence center interpretation of general symmetric Kubo-Ando means, and
related weighted multivariate operator means
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2021'
...
---
_id: '8429'
abstract:
- lang: eng
text: We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability
estimation, an alternative to marker discovery, and accurate genomic prediction,
taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability
parameters in the UK Biobank. We find that only ≤10% of the genetic variation
captured for height, body mass index, cardiovascular disease, and type 2 diabetes
is attributable to proximal regulatory regions within 10kb upstream of genes,
while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to
distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each
chromosome are associated with each trait, with over 3,100 independent exonic
and intronic regions and over 5,400 independent regulatory regions having ≥95%
probability of contributing ≥0.001% to the genetic variance of these four traits.
Our open-source software (GMRM) provides a scalable alternative to current approaches
for biobank data.
acknowledgement: This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181),
and by core funding from the Institute of Science and Technology Austria. We would
like to thank the participants of the cohort studies, and the Ecole Polytechnique
Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity
with their time and the kindness of their support. P.M.V. acknowledges funding from
the Australian National Health and Medical Research Council (1113400) and the Australian
Research Council (FL180100072). L.R. acknowledges funding from the Kjell & Märta
Beijer Foundation (Stockholm, Sweden). We also would like to acknowledge Simone
Rubinacci, Oliver Delanau, Alexander Terenin, Eleonora Porcu, and Mike Goddard for
their useful comments and suggestions.
article_number: '6972'
article_processing_charge: No
article_type: original
author:
- first_name: Marion
full_name: Patxot, Marion
last_name: Patxot
- first_name: Daniel
full_name: Trejo Banos, Daniel
last_name: Trejo Banos
- first_name: Athanasios
full_name: Kousathanas, Athanasios
last_name: Kousathanas
- first_name: Etienne J
full_name: Orliac, Etienne J
last_name: Orliac
- first_name: Sven E
full_name: Ojavee, Sven E
last_name: Ojavee
- first_name: Gerhard
full_name: Moser, Gerhard
last_name: Moser
- first_name: Julia
full_name: Sidorenko, Julia
last_name: Sidorenko
- first_name: Zoltan
full_name: Kutalik, Zoltan
last_name: Kutalik
- first_name: Reedik
full_name: Magi, Reedik
last_name: Magi
- first_name: Peter M
full_name: Visscher, Peter M
last_name: Visscher
- first_name: Lars
full_name: Ronnegard, Lars
last_name: Ronnegard
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: Patxot M, Trejo Banos D, Kousathanas A, et al. Probabilistic inference of the
genetic architecture underlying functional enrichment of complex traits. Nature
Communications. 2021;12(1). doi:10.1038/s41467-021-27258-9
apa: Patxot, M., Trejo Banos, D., Kousathanas, A., Orliac, E. J., Ojavee, S. E.,
Moser, G., … Robinson, M. R. (2021). Probabilistic inference of the genetic architecture
underlying functional enrichment of complex traits. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-021-27258-9
chicago: Patxot, Marion, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J Orliac,
Sven E Ojavee, Gerhard Moser, Julia Sidorenko, et al. “Probabilistic Inference
of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.”
Nature Communications. Springer Nature, 2021. https://doi.org/10.1038/s41467-021-27258-9.
ieee: M. Patxot et al., “Probabilistic inference of the genetic architecture
underlying functional enrichment of complex traits,” Nature Communications,
vol. 12, no. 1. Springer Nature, 2021.
ista: Patxot M, Trejo Banos D, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Sidorenko
J, Kutalik Z, Magi R, Visscher PM, Ronnegard L, Robinson MR. 2021. Probabilistic
inference of the genetic architecture underlying functional enrichment of complex
traits. Nature Communications. 12(1), 6972.
mla: Patxot, Marion, et al. “Probabilistic Inference of the Genetic Architecture
Underlying Functional Enrichment of Complex Traits.” Nature Communications,
vol. 12, no. 1, 6972, Springer Nature, 2021, doi:10.1038/s41467-021-27258-9.
short: M. Patxot, D. Trejo Banos, A. Kousathanas, E.J. Orliac, S.E. Ojavee, G. Moser,
J. Sidorenko, Z. Kutalik, R. Magi, P.M. Visscher, L. Ronnegard, M.R. Robinson,
Nature Communications 12 (2021).
date_created: 2020-09-17T10:52:38Z
date_published: 2021-11-30T00:00:00Z
date_updated: 2025-06-12T06:54:52Z
day: '30'
ddc:
- '610'
department:
- _id: MaRo
doi: 10.1038/s41467-021-27258-9
external_id:
isi:
- '000724450600023'
pmid:
- '34848700'
file:
- access_level: open_access
checksum: 384681be17aff902c149a48f52d13d4f
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-06T07:47:11Z
date_updated: 2021-12-06T07:47:11Z
file_id: '10419'
file_name: 2021_NatComm_Paxtot.pdf
file_size: 6519771
relation: main_file
success: 1
file_date_updated: 2021-12-06T07:47:11Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13063'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Probabilistic inference of the genetic architecture underlying functional enrichment
of complex traits
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2021'
...
---
_id: '8544'
abstract:
- lang: eng
text: The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic
branches, yet this hypothesis has not been causally tested in vivo in the mammalian
brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2
mediate synaptogenesis between granule cells and Purkinje cells in the molecular
layer of the cerebellar cortex. Here we show that sparse but not global knockout
of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular
layer and overelaboration in the superficial molecular layer. Developmental, overexpression,
structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis
defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner.
A generative model of dendritic growth based on competitive synaptogenesis largely
recapitulates GluD2 sparse and global knockout phenotypes. Our results support
the synaptotrophic hypothesis at initial stages of dendrite development, suggest
a second mode in which cumulative synapse formation inhibits further dendrite
growth, and highlight the importance of competition in dendrite morphogenesis.
acknowledgement: We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I.
Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W.
Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members
of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin,
D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript,
and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T.
was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs
Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538)
to L.L.; the European Research Council (ERC) under the European Union's Horizon
2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons
and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI
investigator.
article_processing_charge: No
article_type: original
author:
- first_name: Yukari H.
full_name: Takeo, Yukari H.
last_name: Takeo
- first_name: S. Andrew
full_name: Shuster, S. Andrew
last_name: Shuster
- first_name: Linnie
full_name: Jiang, Linnie
last_name: Jiang
- first_name: Miley
full_name: Hu, Miley
last_name: Hu
- first_name: David J.
full_name: Luginbuhl, David J.
last_name: Luginbuhl
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Mark J.
full_name: Wagner, Mark J.
last_name: Wagner
- first_name: Surya
full_name: Ganguli, Surya
last_name: Ganguli
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
2021;109(4):P629-644.E8. doi:10.1016/j.neuron.2020.11.028
apa: Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke,
T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes
the dendritic arbors of cerebellar Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.11.028
chicago: Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl,
Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive
Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron.
Elsevier, 2021. https://doi.org/10.1016/j.neuron.2020.11.028.
ieee: Y. H. Takeo et al., “GluD2- and Cbln1-mediated competitive synaptogenesis
shapes the dendritic arbors of cerebellar Purkinje cells,” Neuron, vol.
109, no. 4. Elsevier, p. P629–644.E8, 2021.
ista: Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X,
Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
109(4), P629–644.E8.
mla: Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis
Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron, vol.
109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:10.1016/j.neuron.2020.11.028.
short: Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X.
Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021)
P629–644.E8.
date_created: 2020-09-21T11:59:47Z
date_published: 2021-02-17T00:00:00Z
date_updated: 2025-09-10T09:58:28Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2020.11.028
ec_funded: 1
external_id:
isi:
- '000632657400006'
pmid:
- '33352118'
intvolume: ' 109'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.06.14.151258
month: '02'
oa: 1
oa_version: Preprint
page: P629-644.E8
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors
of cerebellar Purkinje cells
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 109
year: '2021'
...
---
_id: '8582'
abstract:
- lang: eng
text: "Cell and tissue polarization is fundamental for plant growth and morphogenesis.
The polar, cellular localization of Arabidopsis PIN‐FORMED (PIN) proteins is crucial
for their function in directional auxin transport. The clustering of PIN polar
cargoes within the plasma membrane has been proposed to be important for the maintenance
of their polar distribution. However, the more detailed features of PIN clusters
and the cellular requirements of cargo clustering remain unclear.\r\nHere, we
characterized PIN clusters in detail by means of multiple advanced microscopy
and quantification methods, such as 3D quantitative imaging or freeze‐fracture
replica labeling. The size and aggregation types of PIN clusters were determined
by electron microscopy at the nanometer level at different polar domains and at
different developmental stages, revealing a strong preference for clustering at
the polar domains.\r\nPharmacological and genetic studies revealed that PIN clusters
depend on phosphoinositol pathways, cytoskeletal structures and specific cell‐wall
components as well as connections between the cell wall and the plasma membrane.\r\nThis
study identifies the role of different cellular processes and structures in polar
cargo clustering and provides initial mechanistic insight into the maintenance
of polarity in plants and other systems."
acknowledged_ssus:
- _id: Bio
acknowledgement: We thank Dr Ingo Heilmann (Martin‐Luther‐University Halle‐Wittenberg)
for the XVE>>PIP5K1‐YFP line, Dr Brad Day (Michigan State University) for the ndr1‐1
mutant and the complementation lines, and Dr Patricia C. Zambryski (University of
California, Berkeley) for the 35S::P30‐GFP line, the Bioimaging team (IST Austria)
for assistance with imaging, group members for discussions, Martine De Cock for
help in preparing the manuscript and Nataliia Gnyliukh for critical reading and
revision of the manuscript. This project received funding from the European Research
Council (ERC) under the European Union's Horizon 2020 research and innovation program
(grant agreement No. 742985) and Comisión Nacional de Investigación Científica y
Tecnológica (Project CONICYT‐PAI 82130047). DvW received funding from the People
Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme
(FP7/2007‐2013) under REA grant agreement no. 291734.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Hongjiang
full_name: Li, Hongjiang
id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0001-5039-9660
- first_name: Daniel
full_name: von Wangenheim, Daniel
id: 49E91952-F248-11E8-B48F-1D18A9856A87
last_name: von Wangenheim
orcid: 0000-0002-6862-1247
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Nasser
full_name: Darwish-Miranda, Nasser
id: 39CD9926-F248-11E8-B48F-1D18A9856A87
last_name: Darwish-Miranda
orcid: 0000-0002-8821-8236
- first_name: Satoshi
full_name: Naramoto, Satoshi
last_name: Naramoto
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Riet
full_name: de Rycke, Riet
last_name: de Rycke
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Daniel J
full_name: Gütl, Daniel J
id: 381929CE-F248-11E8-B48F-1D18A9856A87
last_name: Gütl
- first_name: Ricardo
full_name: Tejos, Ricardo
last_name: Tejos
- first_name: Peter
full_name: Grones, Peter
id: 399876EC-F248-11E8-B48F-1D18A9856A87
last_name: Grones
- first_name: Meiyu
full_name: Ke, Meiyu
last_name: Ke
- first_name: Xu
full_name: Chen, Xu
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Jan
full_name: Dettmer, Jan
last_name: Dettmer
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li H, von Wangenheim D, Zhang X, et al. Cellular requirements for PIN polar
cargo clustering in Arabidopsis thaliana. New Phytologist. 2021;229(1):351-369.
doi:10.1111/nph.16887
apa: Li, H., von Wangenheim, D., Zhang, X., Tan, S., Darwish-Miranda, N., Naramoto,
S., … Friml, J. (2021). Cellular requirements for PIN polar cargo clustering in
Arabidopsis thaliana. New Phytologist. Wiley. https://doi.org/10.1111/nph.16887
chicago: Li, Hongjiang, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda,
Satoshi Naramoto, Krzysztof T Wabnik, et al. “Cellular Requirements for PIN Polar
Cargo Clustering in Arabidopsis Thaliana.” New Phytologist. Wiley, 2021.
https://doi.org/10.1111/nph.16887.
ieee: H. Li et al., “Cellular requirements for PIN polar cargo clustering
in Arabidopsis thaliana,” New Phytologist, vol. 229, no. 1. Wiley, pp.
351–369, 2021.
ista: Li H, von Wangenheim D, Zhang X, Tan S, Darwish-Miranda N, Naramoto S, Wabnik
KT, de Rycke R, Kaufmann W, Gütl DJ, Tejos R, Grones P, Ke M, Chen X, Dettmer
J, Friml J. 2021. Cellular requirements for PIN polar cargo clustering in Arabidopsis
thaliana. New Phytologist. 229(1), 351–369.
mla: Li, Hongjiang, et al. “Cellular Requirements for PIN Polar Cargo Clustering
in Arabidopsis Thaliana.” New Phytologist, vol. 229, no. 1, Wiley, 2021,
pp. 351–69, doi:10.1111/nph.16887.
short: H. Li, D. von Wangenheim, X. Zhang, S. Tan, N. Darwish-Miranda, S. Naramoto,
K.T. Wabnik, R. de Rycke, W. Kaufmann, D.J. Gütl, R. Tejos, P. Grones, M. Ke,
X. Chen, J. Dettmer, J. Friml, New Phytologist 229 (2021) 351–369.
date_created: 2020-09-28T08:59:28Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-06-12T06:32:24Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: EM-Fac
- _id: Bio
- _id: EvBe
doi: 10.1111/nph.16887
ec_funded: 1
external_id:
isi:
- '000570187900001'
pmid:
- '32810889'
file:
- access_level: open_access
checksum: b45621607b4cab97eeb1605ab58e896e
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T09:44:17Z
date_updated: 2021-02-04T09:44:17Z
file_id: '9084'
file_name: 2021_NewPhytologist_Li.pdf
file_size: 4061962
relation: main_file
success: 1
file_date_updated: 2021-02-04T09:44:17Z
has_accepted_license: '1'
intvolume: ' 229'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 351-369
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 229
year: '2021'
...
---
_id: '8603'
abstract:
- lang: eng
text: We consider the Fröhlich polaron model in the strong coupling limit. It is
well‐known that to leading order the ground state energy is given by the (classical)
Pekar energy. In this work, we establish the subleading correction, describing
quantum fluctuation about the classical limit. Our proof applies to a model of
a confined polaron, where both the electron and the polarization field are restricted
to a set of finite volume, with linear size determined by the natural length scale
of the Pekar problem.
acknowledgement: Partial support through National Science Foundation GrantDMS-1363432
(R.L.F.) and the European Research Council (ERC) under the Euro-pean Union’s Horizon
2020 research and innovation programme (grant agreementNo 694227; R.S.), is acknowledged.
Open access funding enabled and organizedby Projekt DEAL.
article_processing_charge: No
article_type: original
author:
- first_name: Rupert
full_name: Frank, Rupert
last_name: Frank
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Frank R, Seiringer R. Quantum corrections to the Pekar asymptotics of a strongly
coupled polaron. Communications on Pure and Applied Mathematics. 2021;74(3):544-588.
doi:10.1002/cpa.21944
apa: Frank, R., & Seiringer, R. (2021). Quantum corrections to the Pekar asymptotics
of a strongly coupled polaron. Communications on Pure and Applied Mathematics.
Wiley. https://doi.org/10.1002/cpa.21944
chicago: Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar
Asymptotics of a Strongly Coupled Polaron.” Communications on Pure and Applied
Mathematics. Wiley, 2021. https://doi.org/10.1002/cpa.21944.
ieee: R. Frank and R. Seiringer, “Quantum corrections to the Pekar asymptotics of
a strongly coupled polaron,” Communications on Pure and Applied Mathematics,
vol. 74, no. 3. Wiley, pp. 544–588, 2021.
ista: Frank R, Seiringer R. 2021. Quantum corrections to the Pekar asymptotics of
a strongly coupled polaron. Communications on Pure and Applied Mathematics. 74(3),
544–588.
mla: Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics
of a Strongly Coupled Polaron.” Communications on Pure and Applied Mathematics,
vol. 74, no. 3, Wiley, 2021, pp. 544–88, doi:10.1002/cpa.21944.
short: R. Frank, R. Seiringer, Communications on Pure and Applied Mathematics 74
(2021) 544–588.
date_created: 2020-10-04T22:01:37Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2025-07-10T11:57:12Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1002/cpa.21944
ec_funded: 1
external_id:
isi:
- '000572991500001'
file:
- access_level: open_access
checksum: 5f665ffa6e6dd958aec5c3040cbcfa84
content_type: application/pdf
creator: dernst
date_created: 2021-03-11T10:03:30Z
date_updated: 2021-03-11T10:03:30Z
file_id: '9236'
file_name: 2021_CommPureApplMath_Frank.pdf
file_size: 334987
relation: main_file
success: 1
file_date_updated: 2021-03-11T10:03:30Z
has_accepted_license: '1'
intvolume: ' 74'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 544-588
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Communications on Pure and Applied Mathematics
publication_identifier:
eissn:
- 1097-0312
issn:
- 0010-3640
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum corrections to the Pekar asymptotics of a strongly coupled polaron
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 74
year: '2021'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '8606'
abstract:
- lang: eng
text: The leaf is a crucial organ evolved with remarkable morphological diversity
to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis,
flowering rates, disease resistance, and yield. Although many genes regulating
leaf development have been identified in the past years, the precise regulatory
architecture underlying the generation of diverse leaf shapes remains to be elucidated.
We used cotton as a reference model to probe the genetic framework underlying
divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16‐1
and GhKNOX2‐1 genes might be potential regulators of leaf shape. We functionally
characterized the auxin‐responsive factor ARF16‐1 acting upstream of GhKNOX2‐1
to determine leaf morphology in cotton. The transcription of GhARF16‐1 was significantly
higher in lobed‐leaved cotton than in smooth‐leaved cotton. Furthermore, the overexpression
of GhARF16‐1 led to the upregulation of GhKNOX2‐1 and resulted in more and deeper
serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing
GhKNOX2‐1. We found that GhARF16‐1 specifically bound to the promoter of GhKNOX2‐1
to induce its expression. The heterologous expression of GhARF16‐1 and GhKNOX2‐1
in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed
that GhKNOX2‐1 is epistatic to GhARF16‐1 in Arabidopsis, suggesting that the GhARF16‐1
and GhKNOX2‐1 interaction paradigm also functions to regulate leaf shape in Arabidopsis.
To our knowledge, our results uncover a novel mechanism by which auxin, through
the key component ARF16‐1 and its downstream‐activated gene KNOX2‐1, determines
leaf morphology in eudicots.
acknowledgement: We are thankful to Professor Yuxian Zhu from Wuhan University for
his extremely valuable remarks and helpful comments on the manuscript. This work
was supported by the Shaanxi Natural Science Foundation (2019JQ‐062 and 2020JQ‐410),
Shaanxi Youth Entrusted Talents Program (20190205), China Postdoctoral Science Foundation
(2018M640947, 2020T130394), Shaanxi Postdoctoral Project (2018BSHYDZZ76), Natural
Science Basic Research Plan in Shaanxi Province of China (2018JZ3006), Fundamental
Research Funds for the Central Universities (GK201903064, GK201901004, GK202002005
and GK202001004), and State Key Laboratory of Cotton Biology Open Fund (CB2020A12).
article_processing_charge: No
article_type: original
author:
- first_name: P
full_name: He, P
last_name: He
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: H
full_name: Li, H
last_name: Li
- first_name: X
full_name: Fu, X
last_name: Fu
- first_name: H
full_name: Shang, H
last_name: Shang
- first_name: C
full_name: Zou, C
last_name: Zou
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: G
full_name: Xiao, G
last_name: Xiao
citation:
ama: He P, Zhang Y, Li H, et al. GhARF16-1 modulates leaf development by transcriptionally
regulating the GhKNOX2-1 gene in cotton. Plant Biotechnology Journal. 2021;19(3):548-562.
doi:10.1111/pbi.13484
apa: He, P., Zhang, Y., Li, H., Fu, X., Shang, H., Zou, C., … Xiao, G. (2021). GhARF16-1
modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene
in cotton. Plant Biotechnology Journal. Wiley. https://doi.org/10.1111/pbi.13484
chicago: He, P, Yuzhou Zhang, H Li, X Fu, H Shang, C Zou, Jiří Friml, and G Xiao.
“GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1
Gene in Cotton.” Plant Biotechnology Journal. Wiley, 2021. https://doi.org/10.1111/pbi.13484.
ieee: P. He et al., “GhARF16-1 modulates leaf development by transcriptionally
regulating the GhKNOX2-1 gene in cotton,” Plant Biotechnology Journal,
vol. 19, no. 3. Wiley, pp. 548–562, 2021.
ista: He P, Zhang Y, Li H, Fu X, Shang H, Zou C, Friml J, Xiao G. 2021. GhARF16-1
modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene
in cotton. Plant Biotechnology Journal. 19(3), 548–562.
mla: He, P., et al. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating
the GhKNOX2-1 Gene in Cotton.” Plant Biotechnology Journal, vol. 19, no.
3, Wiley, 2021, pp. 548–62, doi:10.1111/pbi.13484.
short: P. He, Y. Zhang, H. Li, X. Fu, H. Shang, C. Zou, J. Friml, G. Xiao, Plant
Biotechnology Journal 19 (2021) 548–562.
date_created: 2020-10-05T12:44:33Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2025-07-10T11:57:13Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/pbi.13484
external_id:
isi:
- '000577682300001'
pmid:
- '32981232'
file:
- access_level: open_access
checksum: 63845be37fb962586e0c7773f2355970
content_type: application/pdf
creator: dernst
date_created: 2021-04-12T12:29:07Z
date_updated: 2021-04-12T12:29:07Z
file_id: '9321'
file_name: 2021_PlantBiotechJournal_He.pdf
file_size: 15691871
relation: main_file
success: 1
file_date_updated: 2021-04-12T12:29:07Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 548-562
pmid: 1
publication: Plant Biotechnology Journal
publication_identifier:
eissn:
- 1467-7652
issn:
- 1467-7644
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1
gene in cotton
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2021'
...
---
_id: '8608'
abstract:
- lang: eng
text: To adapt to the diverse array of biotic and abiotic cues, plants have evolved
sophisticated mechanisms to sense changes in environmental conditions and modulate
their growth. Growth-promoting hormones and defence signalling fine tune plant
development antagonistically. During host-pathogen interactions, this defence-growth
trade-off is mediated by the counteractive effects of the defence hormone salicylic
acid (SA) and the growth hormone auxin. Here we revealed an underlying mechanism
of SA regulating auxin signalling by constraining the plasma membrane dynamics
of PIN2 auxin efflux transporter in Arabidopsis thaliana roots. The lateral diffusion
of PIN2 proteins is constrained by SA signalling, during which PIN2 proteins are
condensed into hyperclusters depending on REM1.2-mediated nanodomain compartmentalisation.
Furthermore, membrane nanodomain compartmentalisation by SA or Remorin (REM) assembly
significantly suppressed clathrin-mediated endocytosis. Consequently, SA-induced
heterogeneous surface condensation disrupted asymmetric auxin distribution and
the resultant gravitropic response. Our results demonstrated a defence-growth
trade-off mechanism by which SA signalling crosstalked with auxin transport by
concentrating membrane-resident PIN2 into heterogeneous compartments.
acknowledgement: This work was supported by the National Key Research andDevelopment
Programme of China (2017YFA0506100), theNational Natural Science Foundation of China
(31870170 and31701168), and the Fok Ying Tung Education Foundation(161027) to XC;
NTU startup grant (M4081533) and NIM/01/2016 (NTU, Singapore) to YM. We thank Lei
Shi andZhongquan Lin for microscopy assistance.
article_processing_charge: No
article_type: original
author:
- first_name: M
full_name: Ke, M
last_name: Ke
- first_name: Z
full_name: Ma, Z
last_name: Ma
- first_name: D
full_name: Wang, D
last_name: Wang
- first_name: Y
full_name: Sun, Y
last_name: Sun
- first_name: C
full_name: Wen, C
last_name: Wen
- first_name: D
full_name: Huang, D
last_name: Huang
- first_name: Z
full_name: Chen, Z
last_name: Chen
- first_name: L
full_name: Yang, L
last_name: Yang
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: R
full_name: Li, R
last_name: Li
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Y
full_name: Miao, Y
last_name: Miao
- first_name: X
full_name: Chen, X
last_name: Chen
citation:
ama: Ke M, Ma Z, Wang D, et al. Salicylic acid regulates PIN2 auxin transporter
hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain
organization in Arabidopsis thaliana. New Phytologist. 2021;229(2):963-978.
doi:10.1111/nph.16915
apa: Ke, M., Ma, Z., Wang, D., Sun, Y., Wen, C., Huang, D., … Chen, X. (2021). Salicylic
acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth
via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. New
Phytologist. Wiley. https://doi.org/10.1111/nph.16915
chicago: Ke, M, Z Ma, D Wang, Y Sun, C Wen, D Huang, Z Chen, et al. “Salicylic Acid
Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth
via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.”
New Phytologist. Wiley, 2021. https://doi.org/10.1111/nph.16915.
ieee: M. Ke et al., “Salicylic acid regulates PIN2 auxin transporter hyper-clustering
and root gravitropic growth via Remorin-dependent lipid nanodomain organization
in Arabidopsis thaliana,” New Phytologist, vol. 229, no. 2. Wiley, pp.
963–978, 2021.
ista: Ke M, Ma Z, Wang D, Sun Y, Wen C, Huang D, Chen Z, Yang L, Tan S, Li R, Friml
J, Miao Y, Chen X. 2021. Salicylic acid regulates PIN2 auxin transporter hyper-clustering
and root gravitropic growth via Remorin-dependent lipid nanodomain organization
in Arabidopsis thaliana. New Phytologist. 229(2), 963–978.
mla: Ke, M., et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering
and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization
in Arabidopsis Thaliana.” New Phytologist, vol. 229, no. 2, Wiley, 2021,
pp. 963–78, doi:10.1111/nph.16915.
short: M. Ke, Z. Ma, D. Wang, Y. Sun, C. Wen, D. Huang, Z. Chen, L. Yang, S. Tan,
R. Li, J. Friml, Y. Miao, X. Chen, New Phytologist 229 (2021) 963–978.
date_created: 2020-10-05T12:45:36Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-09-05T16:06:24Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.16915
external_id:
isi:
- '000573568000001'
pmid:
- '32901934'
file:
- access_level: open_access
checksum: d36b6a8c6fafab66264e0d27114dae63
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T09:53:16Z
date_updated: 2021-02-04T09:53:16Z
file_id: '9085'
file_name: 2021_NewPhytologist_Ke.pdf
file_size: 3674502
relation: main_file
success: 1
file_date_updated: 2021-02-04T09:53:16Z
has_accepted_license: '1'
intvolume: ' 229'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 963-978
pmid: 1
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646x
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic
growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 229
year: '2021'
...
---
_id: '8673'
abstract:
- lang: eng
text: In RuCl3, inelastic neutron scattering and Raman spectroscopy reveal a continuum
of non-spin-wave excitations that persists to high temperature, suggesting the
presence of a spin liquid state on a honeycomb lattice. In the context of the
Kitaev model, finite magnetic fields introduce interactions between the elementary
excitations, and thus the effects of high magnetic fields that are comparable
to the spin-exchange energy scale must be explored. Here, we report measurements
of the magnetotropic coefficient—the thermodynamic coefficient associated with
magnetic anisotropy—over a wide range of magnetic fields and temperatures. We
find that magnetic field and temperature compete to determine the magnetic response
in a way that is independent of the large intrinsic exchange-interaction energy.
This emergent scale-invariant magnetic anisotropy provides evidence for a high
degree of exchange frustration that favours the formation of a spin liquid state
in RuCl3.
acknowledgement: We thank M. Baenitz, A. Bangura, R. Coldea, G. Jackeli, S. Kivelson,
S. Nagler, R. Valenti, C. Varma, S. Winter and J. Zaanen for insightful discussions.
Samples were grown at the Max Planck Institute for Chemical Physics of Solids. The
d.c.-field measurements were made at the National High Magnetic Field Laboratory
(NHMFL) in Tallahassee, FL. The pulsed-field measurements were made in the Pulsed
Field Facility of the NHMFL in Los Alamos, NM. All work at the NHMFL is supported
through the National Science Foundation Cooperative Agreement nos. DMR-1157490 and
DMR-1644779, the US Department of Energy and the State of Florida. R.D.M. acknowledges
support from LANL LDRD-DR 20160085 Topology and Strong Correlations. M.C. acknowledges
support from the Department of Energy ‘Science of 100 tesla’ BES programme for high-field
experiments. X-ray data acquisition and analysis was performed at Cornell University.
Research conducted at the Cornell High Energy Synchrotron Source (CHESS) is supported
by the National Science Foundation under award no. DMR-1332208. B.J.R. acknowledges
support from the Institute for Quantum Matter, an Energy Frontier Research Center
funded by the US Department of Energy, Office of Science, Office of Basic Energy
Sciences under award no. DE-SC0019331. Y.L. acknowledges support from the US Department
of Energy through the LANL/LDRD programme and the G.T. Seaborg institute. J.C.P.
is supported by a Gabilan Stanford Graduate Fellowship and an NSF Graduate Research
Fellowship (grant no. DGE-114747). P.J.W.M. acknowledges funding from the Swiss
National Science Foundation through project no. PP00P2-176789.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Ross D.
full_name: McDonald, Ross D.
last_name: McDonald
- first_name: J.P.C.
full_name: Ruff, J.P.C.
last_name: Ruff
- first_name: Maja D.
full_name: Bachmann, Maja D.
last_name: Bachmann
- first_name: You
full_name: Lai, You
last_name: Lai
- first_name: Johanna C.
full_name: Palmstrom, Johanna C.
last_name: Palmstrom
- first_name: David
full_name: Graf, David
last_name: Graf
- first_name: Mun K.
full_name: Chan, Mun K.
last_name: Chan
- first_name: F.F.
full_name: Balakirev, F.F.
last_name: Balakirev
- first_name: J.B.
full_name: Betts, J.B.
last_name: Betts
- first_name: G.S.
full_name: Boebinger, G.S.
last_name: Boebinger
- first_name: Marcus
full_name: Schmidt, Marcus
last_name: Schmidt
- first_name: Michael J.
full_name: Lawler, Michael J.
last_name: Lawler
- first_name: D.A.
full_name: Sokolov, D.A.
last_name: Sokolov
- first_name: Philip J.W.
full_name: Moll, Philip J.W.
last_name: Moll
- first_name: B.J.
full_name: Ramshaw, B.J.
last_name: Ramshaw
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
citation:
ama: Modic KA, McDonald RD, Ruff JPC, et al. Scale-invariant magnetic anisotropy
in RuCl3 at high magnetic fields. Nature Physics. 2021;17:240-244. doi:10.1038/s41567-020-1028-0
apa: Modic, K. A., McDonald, R. D., Ruff, J. P. C., Bachmann, M. D., Lai, Y., Palmstrom,
J. C., … Shekhter, A. (2021). Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-1028-0
chicago: Modic, Kimberly A, Ross D. McDonald, J.P.C. Ruff, Maja D. Bachmann, You
Lai, Johanna C. Palmstrom, David Graf, et al. “Scale-Invariant Magnetic Anisotropy
in RuCl3 at High Magnetic Fields.” Nature Physics. Springer Nature, 2021.
https://doi.org/10.1038/s41567-020-1028-0.
ieee: K. A. Modic et al., “Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields,” Nature Physics, vol. 17. Springer Nature, pp. 240–244,
2021.
ista: Modic KA, McDonald RD, Ruff JPC, Bachmann MD, Lai Y, Palmstrom JC, Graf D,
Chan MK, Balakirev FF, Betts JB, Boebinger GS, Schmidt M, Lawler MJ, Sokolov DA,
Moll PJW, Ramshaw BJ, Shekhter A. 2021. Scale-invariant magnetic anisotropy in
RuCl3 at high magnetic fields. Nature Physics. 17, 240–244.
mla: Modic, Kimberly A., et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at
High Magnetic Fields.” Nature Physics, vol. 17, Springer Nature, 2021,
pp. 240–44, doi:10.1038/s41567-020-1028-0.
short: K.A. Modic, R.D. McDonald, J.P.C. Ruff, M.D. Bachmann, Y. Lai, J.C. Palmstrom,
D. Graf, M.K. Chan, F.F. Balakirev, J.B. Betts, G.S. Boebinger, M. Schmidt, M.J.
Lawler, D.A. Sokolov, P.J.W. Moll, B.J. Ramshaw, A. Shekhter, Nature Physics 17
(2021) 240–244.
corr_author: '1'
date_created: 2020-10-18T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2025-07-10T11:57:16Z
day: '01'
department:
- _id: KiMo
doi: 10.1038/s41567-020-1028-0
external_id:
arxiv:
- '2005.04228'
isi:
- '000575344700003'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.04228
month: '02'
oa: 1
oa_version: Preprint
page: 240-244
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2021'
...
---
_id: '8689'
abstract:
- lang: eng
text: 'This paper continues the discussion started in [CK19] concerning Arnold''s
legacy on classical KAM theory and (some of) its modern developments. We prove
a detailed and explicit `global'' Arnold''s KAM Theorem, which yields, in particular,
the Whitney conjugacy of a non{degenerate, real{analytic, nearly-integrable Hamiltonian
system to an integrable system on a closed, nowhere dense, positive measure subset
of the phase space. Detailed measure estimates on the Kolmogorov''s set are provided
in the case the phase space is: (A) a uniform neighbourhood of an arbitrary (bounded)
set times the d-torus and (B) a domain with C2 boundary times the d-torus. All
constants are explicitly given.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Luigi
full_name: Chierchia, Luigi
last_name: Chierchia
- first_name: Edmond
full_name: Koudjinan, Edmond
id: 52DF3E68-AEFA-11EA-95A4-124A3DDC885E
last_name: Koudjinan
orcid: 0000-0003-2640-4049
citation:
ama: Chierchia L, Koudjinan E. V.I. Arnold’s “‘Global’” KAM theorem and geometric
measure estimates. Regular and Chaotic Dynamics. 2021;26(1):61-88. doi:10.1134/S1560354721010044
apa: Chierchia, L., & Koudjinan, E. (2021). V.I. Arnold’s “‘Global’” KAM theorem
and geometric measure estimates. Regular and Chaotic Dynamics. Springer
Nature. https://doi.org/10.1134/S1560354721010044
chicago: Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem
and Geometric Measure Estimates.” Regular and Chaotic Dynamics. Springer
Nature, 2021. https://doi.org/10.1134/S1560354721010044.
ieee: L. Chierchia and E. Koudjinan, “V.I. Arnold’s ‘“Global”’ KAM theorem and geometric
measure estimates,” Regular and Chaotic Dynamics, vol. 26, no. 1. Springer
Nature, pp. 61–88, 2021.
ista: Chierchia L, Koudjinan E. 2021. V.I. Arnold’s ‘“Global”’ KAM theorem and geometric
measure estimates. Regular and Chaotic Dynamics. 26(1), 61–88.
mla: Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem
and Geometric Measure Estimates.” Regular and Chaotic Dynamics, vol. 26,
no. 1, Springer Nature, 2021, pp. 61–88, doi:10.1134/S1560354721010044.
short: L. Chierchia, E. Koudjinan, Regular and Chaotic Dynamics 26 (2021) 61–88.
date_created: 2020-10-21T14:56:47Z
date_published: 2021-02-03T00:00:00Z
date_updated: 2023-08-07T13:37:27Z
day: '03'
ddc:
- '515'
department:
- _id: VaKa
doi: 10.1134/S1560354721010044
external_id:
arxiv:
- '2010.13243'
isi:
- '000614454700004'
intvolume: ' 26'
isi: 1
issue: '1'
keyword:
- Nearly{integrable Hamiltonian systems
- perturbation theory
- KAM Theory
- Arnold's scheme
- Kolmogorov's set
- primary invariant tori
- Lagrangian tori
- measure estimates
- small divisors
- integrability on nowhere dense sets
- Diophantine frequencies.
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2010.13243
month: '02'
oa: 1
oa_version: Preprint
page: 61-88
publication: Regular and Chaotic Dynamics
publication_identifier:
issn:
- 1560-3547
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: V.I. Arnold's ''Global'' KAM theorem and geometric measure estimates
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 26
year: '2021'
...
---
_id: '8708'
abstract:
- lang: eng
text: The Mytilus complex of marine mussel species forms a mosaic of hybrid zones,
found across temperate regions of the globe. This allows us to study ‘replicated’
instances of secondary contact between closely related species. Previous work
on this complex has shown that local introgression is both widespread and highly
heterogeneous, and has identified SNPs that are outliers of differentiation between
lineages. Here, we developed an ancestry‐informative panel of such SNPs. We then
compared their frequencies in newly sampled populations, including samples from
within the hybrid zones, and parental populations at different distances from
the contact. Results show that close to the hybrid zones, some outlier loci are
near to fixation for the heterospecific allele, suggesting enhanced local introgression,
or the local sweep of a shared ancestral allele. Conversely, genomic cline analyses,
treating local parental populations as the reference, reveal a globally high concordance
among loci, albeit with a few signals of asymmetric introgression. Enhanced local
introgression at specific loci is consistent with the early transfer of adaptive
variants after contact, possibly including asymmetric bi‐stable variants (Dobzhansky‐Muller
incompatibilities), or haplotypes loaded with fewer deleterious mutations. Having
escaped one barrier, however, these variants can be trapped or delayed at the
next barrier, confining the introgression locally. These results shed light on
the decay of species barriers during phases of contact.
acknowledgement: Data used in this work were partly produced through the genotyping
and sequencing facilities of ISEM and LabEx CeMEB, an ANR ‘Investissements d'avenir’
program (ANR‐10‐LABX‐04‐01) This project benefited from the Montpellier Bioinformatics
Biodiversity platform supported by the LabEx CeMEB. We thank Norah Saarman, Grant
Pogson, Célia Gosset and Pierre‐Alexandre Gagnaire for providing samples. This work
was funded by a Languedoc‐Roussillon ‘Chercheur(se)s d'Avenir’ grant (Connect7 project).
P. Strelkov was supported by the Russian Science Foundation project 19‐74‐20024.
This is article 2020‐240 of Institut des Sciences de l'Evolution de Montpellier.
article_processing_charge: No
article_type: original
author:
- first_name: Alexis
full_name: Simon, Alexis
last_name: Simon
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Tahani
full_name: El Ayari, Tahani
last_name: El Ayari
- first_name: Cathy
full_name: Liautard‐Haag, Cathy
last_name: Liautard‐Haag
- first_name: Petr
full_name: Strelkov, Petr
last_name: Strelkov
- first_name: John J
full_name: Welch, John J
last_name: Welch
- first_name: Nicolas
full_name: Bierne, Nicolas
last_name: Bierne
citation:
ama: Simon A, Fraisse C, El Ayari T, et al. How do species barriers decay? Concordance
and local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary
Biology. 2021;34(1):208-223. doi:10.1111/jeb.13709
apa: Simon, A., Fraisse, C., El Ayari, T., Liautard‐Haag, C., Strelkov, P., Welch,
J. J., & Bierne, N. (2021). How do species barriers decay? Concordance and
local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary
Biology. Wiley. https://doi.org/10.1111/jeb.13709
chicago: Simon, Alexis, Christelle Fraisse, Tahani El Ayari, Cathy Liautard‐Haag,
Petr Strelkov, John J Welch, and Nicolas Bierne. “How Do Species Barriers Decay?
Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” Journal
of Evolutionary Biology. Wiley, 2021. https://doi.org/10.1111/jeb.13709.
ieee: A. Simon et al., “How do species barriers decay? Concordance and local
introgression in mosaic hybrid zones of mussels,” Journal of Evolutionary Biology,
vol. 34, no. 1. Wiley, pp. 208–223, 2021.
ista: Simon A, Fraisse C, El Ayari T, Liautard‐Haag C, Strelkov P, Welch JJ, Bierne
N. 2021. How do species barriers decay? Concordance and local introgression in
mosaic hybrid zones of mussels. Journal of Evolutionary Biology. 34(1), 208–223.
mla: Simon, Alexis, et al. “How Do Species Barriers Decay? Concordance and Local
Introgression in Mosaic Hybrid Zones of Mussels.” Journal of Evolutionary Biology,
vol. 34, no. 1, Wiley, 2021, pp. 208–23, doi:10.1111/jeb.13709.
short: A. Simon, C. Fraisse, T. El Ayari, C. Liautard‐Haag, P. Strelkov, J.J. Welch,
N. Bierne, Journal of Evolutionary Biology 34 (2021) 208–223.
date_created: 2020-10-25T23:01:20Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-07-10T12:01:23Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1111/jeb.13709
external_id:
isi:
- '000579599700001'
pmid:
- '33045123'
intvolume: ' 34'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/818559
month: '01'
oa: 1
oa_version: Preprint
page: 208-223
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '13073'
relation: research_data
status: public
scopus_import: '1'
status: public
title: How do species barriers decay? Concordance and local introgression in mosaic
hybrid zones of mussels
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2021'
...
---
_id: '8723'
abstract:
- lang: eng
text: Deep learning at scale is dominated by communication time. Distributing samples
across nodes usually yields the best performance, but poses scaling challenges
due to global information dissemination and load imbalance across uneven sample
lengths. State-of-the-art decentralized optimizers mitigate the problem, but require
more iterations to achieve the same accuracy as their globally-communicating counterparts.
We present Wait-Avoiding Group Model Averaging (WAGMA) SGD, a wait-avoiding stochastic
optimizer that reduces global communication via subgroup weight exchange. The
key insight is a combination of algorithmic changes to the averaging scheme and
the use of a group allreduce operation. We prove the convergence of WAGMA-SGD,
and empirically show that it retains convergence rates similar to Allreduce-SGD.
For evaluation, we train ResNet-50 on ImageNet; Transformer for machine translation;
and deep reinforcement learning for navigation at scale. Compared with state-of-the-art
decentralized SGD variants, WAGMA-SGD significantly improves training throughput
(e.g., 2.1× on 1,024 GPUs for reinforcement learning), and achieves the fastest
time-to-solution (e.g., the highest score using the shortest training time for
Transformer).
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Hori-\r\nzon 2020 programme under Grant DAPP, Grant
678880; EPi-GRAM-HS, Grant 801039; and ERC Starting Grant ScaleML, Grant 805223.
The work of Tal Ben-Nun is supported by the Swiss National Science Foundation (Ambizione
Project No. 185778). The work of Nikoli Dryden is supported by the ETH Postdoctoral
Fellowship. The authors would like to thank the Swiss National Supercomputing Center
for providing the computing resources and technical support."
article_number: '9271898'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Shigang
full_name: Li, Shigang
last_name: Li
- first_name: Tal Ben-Nun
full_name: Tal Ben-Nun, Tal Ben-Nun
last_name: Tal Ben-Nun
- first_name: Giorgi
full_name: Nadiradze, Giorgi
id: 3279A00C-F248-11E8-B48F-1D18A9856A87
last_name: Nadiradze
orcid: 0000-0001-5634-0731
- first_name: Salvatore Di
full_name: Girolamo, Salvatore Di
last_name: Girolamo
- first_name: Nikoli
full_name: Dryden, Nikoli
last_name: Dryden
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Torsten
full_name: Hoefler, Torsten
last_name: Hoefler
citation:
ama: Li S, Tal Ben-Nun TB-N, Nadiradze G, et al. Breaking (global) barriers in parallel
stochastic optimization with wait-avoiding group averaging. IEEE Transactions
on Parallel and Distributed Systems. 2021;32(7). doi:10.1109/TPDS.2020.3040606
apa: Li, S., Tal Ben-Nun, T. B.-N., Nadiradze, G., Girolamo, S. D., Dryden, N.,
Alistarh, D.-A., & Hoefler, T. (2021). Breaking (global) barriers in parallel
stochastic optimization with wait-avoiding group averaging. IEEE Transactions
on Parallel and Distributed Systems. IEEE. https://doi.org/10.1109/TPDS.2020.3040606
chicago: Li, Shigang, Tal Ben-Nun Tal Ben-Nun, Giorgi Nadiradze, Salvatore Di Girolamo,
Nikoli Dryden, Dan-Adrian Alistarh, and Torsten Hoefler. “Breaking (Global) Barriers
in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” IEEE
Transactions on Parallel and Distributed Systems. IEEE, 2021. https://doi.org/10.1109/TPDS.2020.3040606.
ieee: S. Li et al., “Breaking (global) barriers in parallel stochastic optimization
with wait-avoiding group averaging,” IEEE Transactions on Parallel and Distributed
Systems, vol. 32, no. 7. IEEE, 2021.
ista: Li S, Tal Ben-Nun TB-N, Nadiradze G, Girolamo SD, Dryden N, Alistarh D-A,
Hoefler T. 2021. Breaking (global) barriers in parallel stochastic optimization
with wait-avoiding group averaging. IEEE Transactions on Parallel and Distributed
Systems. 32(7), 9271898.
mla: Li, Shigang, et al. “Breaking (Global) Barriers in Parallel Stochastic Optimization
with Wait-Avoiding Group Averaging.” IEEE Transactions on Parallel and Distributed
Systems, vol. 32, no. 7, 9271898, IEEE, 2021, doi:10.1109/TPDS.2020.3040606.
short: S. Li, T.B.-N. Tal Ben-Nun, G. Nadiradze, S.D. Girolamo, N. Dryden, D.-A.
Alistarh, T. Hoefler, IEEE Transactions on Parallel and Distributed Systems 32
(2021).
date_created: 2020-11-05T15:25:43Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2025-07-10T12:01:23Z
day: '01'
department:
- _id: DaAl
doi: 10.1109/TPDS.2020.3040606
ec_funded: 1
external_id:
arxiv:
- '2005.00124'
isi:
- '000621405200019'
intvolume: ' 32'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.00124
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: IEEE Transactions on Parallel and Distributed Systems
publication_identifier:
issn:
- 1045-9219
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaking (global) barriers in parallel stochastic optimization with wait-avoiding
group averaging
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2021'
...
---
_id: '8730'
abstract:
- lang: eng
text: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict
at the blood–brain barrier (BBB) the brain distribution of the majority of currently
known molecularly targeted anticancer drugs. To improve brain delivery of dual
ABCB1/ABCG2 substrates, both ABCB1 and ABCG2 need to be inhibited simultaneously
at the BBB. We examined the feasibility of simultaneous ABCB1/ABCG2 inhibition
with i.v. co-infusion of erlotinib and tariquidar by studying brain distribution
of the model ABCB1/ABCG2 substrate [11C]erlotinib in mice and rhesus macaques
with PET. Tolerability of the erlotinib/tariquidar combination was assessed in
human embryonic stem cell-derived cerebral organoids. In mice and macaques, baseline
brain distribution of [11C]erlotinib was low (brain distribution volume, VT,brain < 0.3 mL/cm3).
Co-infusion of erlotinib and tariquidar increased VT,brain in mice by 3.0-fold
and in macaques by 3.4- to 5.0-fold, while infusion of erlotinib alone or tariquidar
alone led to less pronounced VT,brain increases in both species. Treatment of
cerebral organoids with erlotinib/tariquidar led to an induction of Caspase-3-dependent
apoptosis. Co-infusion of erlotinib/tariquidar may potentially allow for complete
ABCB1/ABCG2 inhibition at the BBB, while simultaneously achieving brain-targeted
EGFR inhibition. Our protocol may be applicable to enhance brain delivery of molecularly
targeted anticancer drugs for a more effective treatment of brain tumors.
article_processing_charge: No
article_type: original
author:
- first_name: N
full_name: Tournier, N
last_name: Tournier
- first_name: S
full_name: Goutal, S
last_name: Goutal
- first_name: S
full_name: Mairinger, S
last_name: Mairinger
- first_name: IH
full_name: Lozano, IH
last_name: Lozano
- first_name: T
full_name: Filip, T
last_name: Filip
- first_name: M
full_name: Sauberer, M
last_name: Sauberer
- first_name: F
full_name: Caillé, F
last_name: Caillé
- first_name: L
full_name: Breuil, L
last_name: Breuil
- first_name: J
full_name: Stanek, J
last_name: Stanek
- first_name: AF
full_name: Freeman, AF
last_name: Freeman
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: C
full_name: Truillet, C
last_name: Truillet
- first_name: T
full_name: Wanek, T
last_name: Wanek
- first_name: O
full_name: Langer, O
last_name: Langer
citation:
ama: Tournier N, Goutal S, Mairinger S, et al. Complete inhibition of ABCB1 and
ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to
improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal
of Cerebral Blood Flow and Metabolism. 2021;41(7):1634-1646. doi:10.1177/0271678X20965500
apa: Tournier, N., Goutal, S., Mairinger, S., Lozano, I., Filip, T., Sauberer, M.,
… Langer, O. (2021). Complete inhibition of ABCB1 and ABCG2 at the blood-brain
barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of
the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal of Cerebral Blood Flow
and Metabolism. SAGE Publications. https://doi.org/10.1177/0271678X20965500
chicago: Tournier, N, S Goutal, S Mairinger, IH Lozano, T Filip, M Sauberer, F Caillé,
et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion
of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2
Substrate [11C]Erlotinib.” Journal of Cerebral Blood Flow and Metabolism.
SAGE Publications, 2021. https://doi.org/10.1177/0271678X20965500.
ieee: N. Tournier et al., “Complete inhibition of ABCB1 and ABCG2 at the
blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain
delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib,” Journal of Cerebral
Blood Flow and Metabolism, vol. 41, no. 7. SAGE Publications, pp. 1634–1646,
2021.
ista: Tournier N, Goutal S, Mairinger S, Lozano I, Filip T, Sauberer M, Caillé F,
Breuil L, Stanek J, Freeman A, Novarino G, Truillet C, Wanek T, Langer O. 2021.
Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion
of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2
substrate [11C]erlotinib. Journal of Cerebral Blood Flow and Metabolism. 41(7),
1634–1646.
mla: Tournier, N., et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain
Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of
the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” Journal of Cerebral Blood
Flow and Metabolism, vol. 41, no. 7, SAGE Publications, 2021, pp. 1634–46,
doi:10.1177/0271678X20965500.
short: N. Tournier, S. Goutal, S. Mairinger, I. Lozano, T. Filip, M. Sauberer, F.
Caillé, L. Breuil, J. Stanek, A. Freeman, G. Novarino, C. Truillet, T. Wanek,
O. Langer, Journal of Cerebral Blood Flow and Metabolism 41 (2021) 1634–1646.
date_created: 2020-11-06T08:39:01Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-10-18T06:45:30Z
day: '01'
department:
- _id: GaNo
doi: 10.1177/0271678X20965500
external_id:
isi:
- '000664214100012'
pmid:
- '33081568'
intvolume: ' 41'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221757/
month: '07'
oa: 1
oa_version: Published Version
page: 1634-1646
pmid: 1
publication: Journal of Cerebral Blood Flow and Metabolism
publication_identifier:
eissn:
- 1559-7016
issn:
- 0271-678x
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion
of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate
[11C]erlotinib
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2021'
...
---
_id: '8742'
abstract:
- lang: eng
text: We develop a version of Ekedahl’s geometric sieve for integral quadratic forms
of rank at least five. As one ranges over the zeros of such quadratic forms, we
use the sieve to compute the density of coprime values of polynomials, and furthermore,
to address a question about local solubility in families of varieties parameterised
by the zeros.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Roger
full_name: Heath-Brown, Roger
last_name: Heath-Brown
citation:
ama: Browning TD, Heath-Brown R. The geometric sieve for quadrics. Forum Mathematicum.
2021;33(1):147-165. doi:10.1515/forum-2020-0074
apa: Browning, T. D., & Heath-Brown, R. (2021). The geometric sieve for quadrics.
Forum Mathematicum. De Gruyter. https://doi.org/10.1515/forum-2020-0074
chicago: Browning, Timothy D, and Roger Heath-Brown. “The Geometric Sieve for Quadrics.”
Forum Mathematicum. De Gruyter, 2021. https://doi.org/10.1515/forum-2020-0074.
ieee: T. D. Browning and R. Heath-Brown, “The geometric sieve for quadrics,” Forum
Mathematicum, vol. 33, no. 1. De Gruyter, pp. 147–165, 2021.
ista: Browning TD, Heath-Brown R. 2021. The geometric sieve for quadrics. Forum
Mathematicum. 33(1), 147–165.
mla: Browning, Timothy D., and Roger Heath-Brown. “The Geometric Sieve for Quadrics.”
Forum Mathematicum, vol. 33, no. 1, De Gruyter, 2021, pp. 147–65, doi:10.1515/forum-2020-0074.
short: T.D. Browning, R. Heath-Brown, Forum Mathematicum 33 (2021) 147–165.
date_created: 2020-11-08T23:01:25Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-04-15T07:39:01Z
day: '01'
department:
- _id: TiBr
doi: 10.1515/forum-2020-0074
external_id:
arxiv:
- '2003.09593'
isi:
- '000604750900008'
intvolume: ' 33'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2003.09593
month: '01'
oa: 1
oa_version: Preprint
page: 147-165
project:
- _id: 26AEDAB2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P32428
name: New frontiers of the Manin conjecture
publication: Forum Mathematicum
publication_identifier:
eissn:
- 1435-5337
issn:
- 0933-7741
publication_status: published
publisher: De Gruyter
quality_controlled: '1'
scopus_import: '1'
status: public
title: The geometric sieve for quadrics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2021'
...
---
_id: '8743'
abstract:
- lang: eng
text: 'Montane cloud forests are areas of high endemism, and are one of the more
vulnerable terrestrial ecosystems to climate change. Thus, understanding how they
both contribute to the generation of biodiversity, and will respond to ongoing
climate change, are important and related challenges. The widely accepted model
for montane cloud forest dynamics involves upslope forcing of their range limits
with global climate warming. However, limited climate data provides some support
for an alternative model, where range limits are forced downslope with climate
warming. Testing between these two models is challenging, due to the inherent
limitations of climate and pollen records. We overcome this with an alternative
source of historical information, testing between competing model predictions
using genomic data and demographic analyses for a species of beetle tightly associated
to an oceanic island cloud forest. Results unequivocally support the alternative
model: populations that were isolated at higher elevation peaks during the Last
Glacial Maximum are now in contact and hybridizing at lower elevations. Our results
suggest that genomic data are a rich source of information to further understand
how montane cloud forest biodiversity originates, and how it is likely to be impacted
by ongoing climate change.'
acknowledgement: 'This work was financed by the Spanish Agencia Estatal de Investigación
(CGL2017‐85718‐P), awarded to BCE, and co‐financed by FEDER. It was also supported
by the Spanish Ministerio de Ciencia, Innovación y Universidades (EQC2018‐004418‐P),
awarded to BCE. AS‐C was funded by the Spanish Ministerio de Ciencia, Innovación
y Universidades through an FPU PhD fellowship (FPU014/02948). The authors thank
Instituto Tecnológico y de Energías Renovables (ITER), S.A for providing access
to the Teide High‐Performance Computing facility (Teide‐HPC). Fieldwork was supported
by collecting permit AFF 107/17 (sigma number 2017‐00572) kindly provided by the
Cabildo of Tenerife. The authors wish to thank the following for field work and
sample sorting and identification: A. J. Pérez‐Delgado, H. López, and C. Andújar.
We also thank V. García‐Olivares for assistance with laboratory and bioinformatic
work.'
article_processing_charge: No
article_type: original
author:
- first_name: Antonia
full_name: Salces-Castellano, Antonia
last_name: Salces-Castellano
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Paula
full_name: Arribas, Paula
last_name: Arribas
- first_name: Jairo
full_name: Patino, Jairo
last_name: Patino
- first_name: 'Dirk N. '
full_name: 'Karger, Dirk N. '
last_name: Karger
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Brent C.
full_name: Emerson, Brent C.
last_name: Emerson
citation:
ama: Salces-Castellano A, Stankowski S, Arribas P, et al. Long-term cloud forest
response to climate warming revealed by insect speciation history. Evolution.
2021;75(2):231-244. doi:10.1111/evo.14111
apa: Salces-Castellano, A., Stankowski, S., Arribas, P., Patino, J., Karger, D.
N., Butlin, R., & Emerson, B. C. (2021). Long-term cloud forest response to
climate warming revealed by insect speciation history. Evolution. Wiley.
https://doi.org/10.1111/evo.14111
chicago: Salces-Castellano, Antonia, Sean Stankowski, Paula Arribas, Jairo Patino,
Dirk N. Karger, Roger Butlin, and Brent C. Emerson. “Long-Term Cloud Forest Response
to Climate Warming Revealed by Insect Speciation History.” Evolution. Wiley,
2021. https://doi.org/10.1111/evo.14111.
ieee: A. Salces-Castellano et al., “Long-term cloud forest response to climate
warming revealed by insect speciation history,” Evolution, vol. 75, no.
2. Wiley, pp. 231–244, 2021.
ista: Salces-Castellano A, Stankowski S, Arribas P, Patino J, Karger DN, Butlin
R, Emerson BC. 2021. Long-term cloud forest response to climate warming revealed
by insect speciation history. Evolution. 75(2), 231–244.
mla: Salces-Castellano, Antonia, et al. “Long-Term Cloud Forest Response to Climate
Warming Revealed by Insect Speciation History.” Evolution, vol. 75, no.
2, Wiley, 2021, pp. 231–44, doi:10.1111/evo.14111.
short: A. Salces-Castellano, S. Stankowski, P. Arribas, J. Patino, D.N. Karger,
R. Butlin, B.C. Emerson, Evolution 75 (2021) 231–244.
date_created: 2020-11-08T23:01:26Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:09:49Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/evo.14111
external_id:
isi:
- '000583190600001'
pmid:
- '33078844'
intvolume: ' 75'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hdl.handle.net/10261/223937
month: '02'
oa: 1
oa_version: Submitted Version
page: 231-244
pmid: 1
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
issn:
- 0014-3820
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1111/evo.14225
scopus_import: '1'
status: public
title: Long-term cloud forest response to climate warming revealed by insect speciation
history
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 75
year: '2021'
...
---
_id: '8757'
abstract:
- lang: eng
text: Traditional scientific conferences and seminar events have been hugely disrupted
by the COVID-19 pandemic, paving the way for virtual forms of scientific communication
to take hold and be put to the test.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Panagiotis
full_name: Bozelos, Panagiotis
id: 52e9c652-2982-11eb-81d4-b43d94c63700
last_name: Bozelos
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Bozelos P, Vogels TP. Talking science, online. Nature Reviews Neuroscience.
2021;22(1):1-2. doi:10.1038/s41583-020-00408-6
apa: Bozelos, P., & Vogels, T. P. (2021). Talking science, online. Nature
Reviews Neuroscience. Springer Nature. https://doi.org/10.1038/s41583-020-00408-6
chicago: Bozelos, Panagiotis, and Tim P Vogels. “Talking Science, Online.” Nature
Reviews Neuroscience. Springer Nature, 2021. https://doi.org/10.1038/s41583-020-00408-6.
ieee: P. Bozelos and T. P. Vogels, “Talking science, online,” Nature Reviews
Neuroscience, vol. 22, no. 1. Springer Nature, pp. 1–2, 2021.
ista: Bozelos P, Vogels TP. 2021. Talking science, online. Nature Reviews Neuroscience.
22(1), 1–2.
mla: Bozelos, Panagiotis, and Tim P. Vogels. “Talking Science, Online.” Nature
Reviews Neuroscience, vol. 22, no. 1, Springer Nature, 2021, pp. 1–2, doi:10.1038/s41583-020-00408-6.
short: P. Bozelos, T.P. Vogels, Nature Reviews Neuroscience 22 (2021) 1–2.
date_created: 2020-11-15T23:01:18Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-07-10T12:01:24Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41583-020-00408-6
external_id:
isi:
- '000588256300001'
pmid:
- '33173190'
file:
- access_level: open_access
checksum: 7985d7dff94c086e35b94a911d78d9ad
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T10:34:22Z
date_updated: 2021-02-04T10:34:22Z
file_id: '9088'
file_name: 2021_NatureNeuroScience_Bozelos.pdf
file_size: 683634
relation: main_file
success: 1
file_date_updated: 2021-02-04T10:34:22Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1-2
pmid: 1
publication: Nature Reviews Neuroscience
publication_identifier:
eissn:
- 1471-0048
issn:
- 1471-003X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Talking science, online
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2021'
...
---
_id: '8773'
abstract:
- lang: eng
text: Let g be a complex semisimple Lie algebra. We give a classification of contravariant
forms on the nondegenerate Whittaker g-modules Y(χ,η) introduced by Kostant. We
prove that the set of all contravariant forms on Y(χ,η) forms a vector space whose
dimension is given by the cardinality of the Weyl group of g. We also describe
a procedure for parabolically inducing contravariant forms. As a corollary, we
deduce the existence of the Shapovalov form on a Verma module, and provide a formula
for the dimension of the space of contravariant forms on the degenerate Whittaker
modules M(χ,η) introduced by McDowell.
acknowledgement: "We would like to thank Peter Trapa for useful discussions, and Dragan
Milicic and Arun Ram for valuable feedback on the structure of the paper. The first
author acknowledges the support of the European Unions Horizon 2020 research and
innovation programme under the Marie Skodowska-Curie Grant Agreement No. 754411.
The second author is\r\nsupported by the National Science Foundation Award No. 1803059."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adam
full_name: Brown, Adam
id: 70B7FDF6-608D-11E9-9333-8535E6697425
last_name: Brown
- first_name: Anna
full_name: Romanov, Anna
last_name: Romanov
citation:
ama: Brown A, Romanov A. Contravariant forms on Whittaker modules. Proceedings
of the American Mathematical Society. 2021;149(1):37-52. doi:10.1090/proc/15205
apa: Brown, A., & Romanov, A. (2021). Contravariant forms on Whittaker modules.
Proceedings of the American Mathematical Society. American Mathematical
Society. https://doi.org/10.1090/proc/15205
chicago: Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.”
Proceedings of the American Mathematical Society. American Mathematical
Society, 2021. https://doi.org/10.1090/proc/15205.
ieee: A. Brown and A. Romanov, “Contravariant forms on Whittaker modules,” Proceedings
of the American Mathematical Society, vol. 149, no. 1. American Mathematical
Society, pp. 37–52, 2021.
ista: Brown A, Romanov A. 2021. Contravariant forms on Whittaker modules. Proceedings
of the American Mathematical Society. 149(1), 37–52.
mla: Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.”
Proceedings of the American Mathematical Society, vol. 149, no. 1, American
Mathematical Society, 2021, pp. 37–52, doi:10.1090/proc/15205.
short: A. Brown, A. Romanov, Proceedings of the American Mathematical Society 149
(2021) 37–52.
date_created: 2020-11-19T10:17:40Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-04-14T07:43:50Z
day: '01'
department:
- _id: HeEd
doi: 10.1090/proc/15205
ec_funded: 1
external_id:
arxiv:
- '1910.08286'
isi:
- '000600416300004'
intvolume: ' 149'
isi: 1
issue: '1'
keyword:
- Applied Mathematics
- General Mathematics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1910.08286
month: '01'
oa: 1
oa_version: Preprint
page: 37-52
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Proceedings of the American Mathematical Society
publication_identifier:
eissn:
- 1088-6826
issn:
- 0002-9939
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Contravariant forms on Whittaker modules
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 149
year: '2021'
...
---
_id: '8792'
abstract:
- lang: eng
text: This paper is concerned with a non-isothermal Cahn-Hilliard model based on
a microforce balance. The model was derived by A. Miranville and G. Schimperna
starting from the two fundamental laws of Thermodynamics, following M. Gurtin's
two-scale approach. The main working assumptions are made on the behaviour of
the heat flux as the absolute temperature tends to zero and to infinity. A suitable
Ginzburg-Landau free energy is considered. Global-in-time existence for the initial-boundary
value problem associated to the entropy formulation and, in a subcase, also to
the weak formulation of the model is proved by deriving suitable a priori estimates
and by showing weak sequential stability of families of approximating solutions.
At last, some highlights are given regarding a possible approximation scheme compatible
with the a-priori estimates available for the system.
acknowledgement: G. Schimperna has been partially supported by GNAMPA (Gruppo Nazionale
per l'Analisi Matematica, la Probabilità e le loro Applicazioni) of INdAM (Istituto
Nazionale di Alta Matematica).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alice
full_name: Marveggio, Alice
id: 25647992-AA84-11E9-9D75-8427E6697425
last_name: Marveggio
- first_name: Giulio
full_name: Schimperna, Giulio
last_name: Schimperna
citation:
ama: Marveggio A, Schimperna G. On a non-isothermal Cahn-Hilliard model based on
a microforce balance. Journal of Differential Equations. 2021;274(2):924-970.
doi:10.1016/j.jde.2020.10.030
apa: Marveggio, A., & Schimperna, G. (2021). On a non-isothermal Cahn-Hilliard
model based on a microforce balance. Journal of Differential Equations.
Elsevier. https://doi.org/10.1016/j.jde.2020.10.030
chicago: Marveggio, Alice, and Giulio Schimperna. “On a Non-Isothermal Cahn-Hilliard
Model Based on a Microforce Balance.” Journal of Differential Equations.
Elsevier, 2021. https://doi.org/10.1016/j.jde.2020.10.030.
ieee: A. Marveggio and G. Schimperna, “On a non-isothermal Cahn-Hilliard model based
on a microforce balance,” Journal of Differential Equations, vol. 274,
no. 2. Elsevier, pp. 924–970, 2021.
ista: Marveggio A, Schimperna G. 2021. On a non-isothermal Cahn-Hilliard model based
on a microforce balance. Journal of Differential Equations. 274(2), 924–970.
mla: Marveggio, Alice, and Giulio Schimperna. “On a Non-Isothermal Cahn-Hilliard
Model Based on a Microforce Balance.” Journal of Differential Equations,
vol. 274, no. 2, Elsevier, 2021, pp. 924–70, doi:10.1016/j.jde.2020.10.030.
short: A. Marveggio, G. Schimperna, Journal of Differential Equations 274 (2021)
924–970.
date_created: 2020-11-22T23:01:26Z
date_published: 2021-02-15T00:00:00Z
date_updated: 2025-07-10T12:01:25Z
day: '15'
department:
- _id: JuFi
doi: 10.1016/j.jde.2020.10.030
external_id:
arxiv:
- '2004.02618'
isi:
- '000600845300023'
intvolume: ' 274'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
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url: https://arxiv.org/abs/2004.02618
month: '02'
oa: 1
oa_version: Preprint
page: 924-970
publication: Journal of Differential Equations
publication_identifier:
eissn:
- 1090-2732
issn:
- 0022-0396
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On a non-isothermal Cahn-Hilliard model based on a microforce balance
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 274
year: '2021'
...
---
_id: '8816'
abstract:
- lang: eng
text: Area-dependent quantum field theory is a modification of two-dimensional topological
quantum field theory, where one equips each connected component of a bordism with
a positive real number—interpreted as area—which behaves additively under glueing.
As opposed to topological theories, in area-dependent theories the state spaces
can be infinite-dimensional. We introduce the notion of regularised Frobenius
algebras in Hilbert spaces and show that area-dependent theories are in one-to-one
correspondence to commutative regularised Frobenius algebras. We also provide
a state sum construction for area-dependent theories. Our main example is two-dimensional
Yang–Mills theory with compact gauge group, which we treat in detail.
acknowledgement: The authors thank Yuki Arano, Nils Carqueville, Alexei Davydov, Reiner
Lauterbach, Pau Enrique Moliner, Chris Heunen, André Henriques, Ehud Meir, Catherine
Meusburger, Gregor Schaumann, Richard Szabo and Stefan Wagner for helpful discussions
and comments. We also thank the referees for their detailed comments which significantly
improved the exposition of this paper. LS is supported by the DFG Research Training
Group 1670 “Mathematics Inspired by String Theory and Quantum Field Theory”. Open
access funding provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Ingo
full_name: Runkel, Ingo
last_name: Runkel
- first_name: Lorant
full_name: Szegedy, Lorant
id: 7943226E-220E-11EA-94C7-D59F3DDC885E
last_name: Szegedy
orcid: 0000-0003-2834-5054
citation:
ama: Runkel I, Szegedy L. Area-dependent quantum field theory. Communications
in Mathematical Physics. 2021;381(1):83–117. doi:10.1007/s00220-020-03902-1
apa: Runkel, I., & Szegedy, L. (2021). Area-dependent quantum field theory.
Communications in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-020-03902-1
chicago: Runkel, Ingo, and Lorant Szegedy. “Area-Dependent Quantum Field Theory.”
Communications in Mathematical Physics. Springer Nature, 2021. https://doi.org/10.1007/s00220-020-03902-1.
ieee: I. Runkel and L. Szegedy, “Area-dependent quantum field theory,” Communications
in Mathematical Physics, vol. 381, no. 1. Springer Nature, pp. 83–117, 2021.
ista: Runkel I, Szegedy L. 2021. Area-dependent quantum field theory. Communications
in Mathematical Physics. 381(1), 83–117.
mla: Runkel, Ingo, and Lorant Szegedy. “Area-Dependent Quantum Field Theory.” Communications
in Mathematical Physics, vol. 381, no. 1, Springer Nature, 2021, pp. 83–117,
doi:10.1007/s00220-020-03902-1.
short: I. Runkel, L. Szegedy, Communications in Mathematical Physics 381 (2021)
83–117.
date_created: 2020-11-29T23:01:17Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2025-07-10T12:01:25Z
day: '01'
ddc:
- '510'
department:
- _id: MiLe
doi: 10.1007/s00220-020-03902-1
external_id:
isi:
- '000591139000001'
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creator: dernst
date_created: 2021-02-03T15:00:30Z
date_updated: 2021-02-03T15:00:30Z
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intvolume: ' 381'
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language:
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month: '01'
oa: 1
oa_version: Published Version
page: 83–117
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Communications in Mathematical Physics
publication_identifier:
eissn:
- 1432-0916
issn:
- 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Area-dependent quantum field theory
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 381
year: '2021'
...