---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21161'
abstract:
- lang: eng
  text: In many species, sex-biased expression is widespread and thought to contribute
    to sexual dimorphism. While bulk RNA-sequencing has been instrumental in identifying
    strongly sex-biased genes, it lacks resolution to assess variation across cell-types
    and tissue compartments. Using single-nucleus expression data from the Fly Cell
    Atlas, we investigate sex differences in adult Drosophila melanogaster. We find
    that differences in cell-type composition between the sexes are not a major source
    of sex-bias, as for the vast majority of genes, the degree of sex-bias is similar
    regardless of whether sex differences in cell-type composition are controlled
    for or not. Our analysis confirms a deficit of X-linked male-biased genes in the
    body’s somatic tissues that is widespread across cell-types. We also find the
    excess of X-linked female-biased genes to be associated with nervous system cells
    in the head but with epithelial cells in the body’s somatic tissues, showing that
    single-nucleus data crucially resolves sex-bias at the cell-type level. We investigate
    dosage compensation (DC) across 15 tissues and 17 cell-types. We observe that
    it varies throughout the body. Surprisingly, we observe a lack of DC in a cluster
    of main cells within the male accessory glands. This result highlights the importance
    of understanding context-dependent DC.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
acknowledgement: This work was partly funded by an Austrian Science Foundation FWF
  ESPRIT fellowship (10.55776/ESP6331524) to C.B. We would like to thank the Vicoso
  group for their invaluable input and discussions throughout this work. We thank
  Filip Ruzicka for his insightful comments on the manuscript. All computational resources
  were provided by the Scientific Computing Unit at ISTA. This research was also supported
  through resources provided by the Imaging & Optics Facility (IOF) at ISTA.
article_number: '20252471'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Carolina
  full_name: De Castro Barbosa Rodrigues Barata, Carolina
  id: 20565186-803f-11ed-ab7e-96a4ff7694ef
  last_name: De Castro Barbosa Rodrigues Barata
  orcid: 0000-0003-1945-2245
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: de Castro Barbosa Rodrigues Barata C, Vicoso B. Single-nucleus resolution of
    sex-biased expression and dosage compensation in Drosophila melanogaster. <i>Proceedings
    of the Royal Society B Biological Sciences</i>. 2026;293(2063). doi:<a href="https://doi.org/10.1098/rspb.2025.2471">10.1098/rspb.2025.2471</a>
  apa: de Castro Barbosa Rodrigues Barata, C., &#38; Vicoso, B. (2026). Single-nucleus
    resolution of sex-biased expression and dosage compensation in Drosophila melanogaster.
    <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of
    London. <a href="https://doi.org/10.1098/rspb.2025.2471">https://doi.org/10.1098/rspb.2025.2471</a>
  chicago: Castro Barbosa Rodrigues Barata, Carolina de, and Beatriz Vicoso. “Single-Nucleus
    Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.”
    <i>Proceedings of the Royal Society B Biological Sciences</i>. Royal Society of
    London, 2026. <a href="https://doi.org/10.1098/rspb.2025.2471">https://doi.org/10.1098/rspb.2025.2471</a>.
  ieee: C. de Castro Barbosa Rodrigues Barata and B. Vicoso, “Single-nucleus resolution
    of sex-biased expression and dosage compensation in Drosophila melanogaster,”
    <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063.
    Royal Society of London, 2026.
  ista: de Castro Barbosa Rodrigues Barata C, Vicoso B. 2026. Single-nucleus resolution
    of sex-biased expression and dosage compensation in Drosophila melanogaster. Proceedings
    of the Royal Society B Biological Sciences. 293(2063), 20252471.
  mla: de Castro Barbosa Rodrigues Barata, Carolina, and Beatriz Vicoso. “Single-Nucleus
    Resolution of Sex-Biased Expression and Dosage Compensation in Drosophila Melanogaster.”
    <i>Proceedings of the Royal Society B Biological Sciences</i>, vol. 293, no. 2063,
    20252471, Royal Society of London, 2026, doi:<a href="https://doi.org/10.1098/rspb.2025.2471">10.1098/rspb.2025.2471</a>.
  short: C. de Castro Barbosa Rodrigues Barata, B. Vicoso, Proceedings of the Royal
    Society B Biological Sciences 293 (2026).
corr_author: '1'
date_created: 2026-02-08T23:02:49Z
date_published: 2026-01-28T00:00:00Z
date_updated: 2026-02-16T09:27:33Z
day: '28'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1098/rspb.2025.2471
external_id:
  pmid:
  - '41592777'
file:
- access_level: open_access
  checksum: d76afebca0a6f112df0146ae2d929f36
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-16T09:26:02Z
  date_updated: 2026-02-16T09:26:02Z
  file_id: '21226'
  file_name: 2026_RoyalSocPubProceedingsB_Barata.pdf
  file_size: 2230841
  relation: main_file
  success: 1
file_date_updated: 2026-02-16T09:26:02Z
has_accepted_license: '1'
intvolume: '       293'
issue: '2063'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 90ef7108-16d5-11f0-9cad-e6e116913473
  grant_number: ESP 6331524
  name: Does genetic drift set a limit on the adaptive evolution of sex-biased expression?
publication: Proceedings of the Royal Society B Biological Sciences
publication_identifier:
  eissn:
  - 1471-2954
publication_status: published
publisher: Royal Society of London
quality_controlled: '1'
scopus_import: '1'
status: public
title: Single-nucleus resolution of sex-biased expression and dosage compensation
  in Drosophila melanogaster
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 293
year: '2026'
...
---
_id: '21164'
abstract:
- lang: eng
  text: 'Global emission inventories often fail to capture the complexities of vehicular
    pollution in regions with unique fuel mixes, such as Brazil’s extensive biofuel
    use, leading to significant uncertainties in atmospheric modeling. This study
    presents a century-long (1960–2100) bottom-up vehicular emission inventory for
    Brazil, leveraging locally derived emission factors. Our estimates reveal substantial
    discrepancies in magnitude, timing, and speciation of non-CO2 pollutants (CO,
    NMHC, PM2.5) compared to leading global inventories (EDGAR, CEDS, CAMS), highlighting
    critical inaccuracies in widely used data sets. More critically, future projections
    under Shared Socioeconomic Pathways (SSPs) uncover a novel positive feedback mechanism:
    rising temperatures significantly enhance vehicular evaporative nonmethane hydrocarbon
    (NMHC) emissions. This temperature-dependent increase and subsequent NMHC oxidation
    to CO2 suggest an overlooked pathway that could amplify climate warming and air
    pollution globally, particularly after a breakpoint around 2050 (p < 0.05). While
    historical emissions peaked in the 1990s–2000s, nonexhaust PM becomes increasingly
    important. Air quality simulations using our inventory in the MUSICA model show
    good regional PM2.5 agreement but highlight challenges in resolving local primary
    pollutant peaks. This comprehensive inventory provides crucial data for Brazil
    and uncovers globally relevant climate–chemistry interactions, urging a re-evaluation
    of regional specificities in global emission assessments.'
acknowledgement: Part of this material is based upon work supported by the NSF National
  Center for Atmospheric Research, which is a major facility sponsored by the National
  Science Foundation under Cooperative Agreement No. 1852977. Casallas was supported
  by the European Union’s Horizon 2020 research and innovation program under the Marie
  Skłodowska-Curie grant agreement No. 101034413. E. D. Freitas thanks the support
  provided by the National Council for Scientific and Technological Development (CNPq,
  Process number 313210/2022–5). Silva gratefully acknowledges the financial support
  from the National Council for Scientific and Technological Development (CNPq), process
  number 140512/2021–7. P. Lichtig was supported by base funding from the National
  Commission for Atomic Energy (CNEA, Arg.) and by NSF NCAR. R.Y. Ynoue thanks the
  support provided by the National Council for Scientific and Technological Development
  (CNPq, Process number 406728/2022–4). M. A. Franco thanks the support provided by
  the National Council for Scientific and Technological Development (CNPq, Process
  number 407752/2023–4). G. M. Pereira thanks the support by the Fundação de Amparo
  à Pesquisa do Estado de São Paulo (FAPESP; Process numbers 2018/07848–9, 2016/18438–0,
  and 2019/01316–80) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  (CAPES; Process number 88887.103225/2025–00). M.F. Andrade thanks the support by
  FAPESP (Process number 2016/18438–0) and CNPQ (Klimapolis INCT).
article_number: 5c08400
article_processing_charge: No
article_type: original
author:
- first_name: Sergio
  full_name: Ibarra-Espinosa, Sergio
  last_name: Ibarra-Espinosa
- first_name: Edmilson
  full_name: Dias de Freitas, Edmilson
  last_name: Dias de Freitas
- first_name: Benjamin
  full_name: Gaubert, Benjamin
  last_name: Gaubert
- first_name: Pablo
  full_name: Lichtig, Pablo
  last_name: Lichtig
- first_name: Karl
  full_name: Ropkins, Karl
  last_name: Ropkins
- first_name: Iara
  full_name: da Silva, Iara
  last_name: da Silva
- first_name: Guilherme
  full_name: Martins Pereira, Guilherme
  last_name: Martins Pereira
- first_name: Daniel
  full_name: Schuch, Daniel
  last_name: Schuch
- first_name: Janaina
  full_name: Nascimento, Janaina
  last_name: Nascimento
- first_name: Leonardo
  full_name: Hoinaski, Leonardo
  last_name: Hoinaski
- first_name: Leila Droprinchinski
  full_name: Martins, Leila Droprinchinski
  last_name: Martins
- first_name: Mario
  full_name: Gavidia-Calderón, Mario
  last_name: Gavidia-Calderón
- first_name: Angel
  full_name: Vara-Vela, Angel
  last_name: Vara-Vela
- first_name: Taciana
  full_name: Toledo de Almeida Albuquerque, Taciana
  last_name: Toledo de Almeida Albuquerque
- first_name: Rita Yuri
  full_name: Ynoue, Rita Yuri
  last_name: Ynoue
- first_name: Sebastian
  full_name: Diez, Sebastian
  last_name: Diez
- first_name: Zamir
  full_name: Mera, Zamir
  last_name: Mera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Fidel
  full_name: Vallejo, Fidel
  last_name: Vallejo
- first_name: Valeria
  full_name: Diaz, Valeria
  last_name: Diaz
- first_name: Rizzieri
  full_name: Pedruzzi, Rizzieri
  last_name: Pedruzzi
- first_name: Rosana
  full_name: Abrutzky, Rosana
  last_name: Abrutzky
- first_name: Marco A.
  full_name: Franco, Marco A.
  last_name: Franco
- first_name: Nicolas
  full_name: Huneeus, Nicolas
  last_name: Huneeus
- first_name: Hector
  full_name: Jorquera, Hector
  last_name: Jorquera
- first_name: Luis Carlos
  full_name: Belalcázar-Cerón, Luis Carlos
  last_name: Belalcázar-Cerón
- first_name: Néstor Y.
  full_name: Rojas, Néstor Y.
  last_name: Rojas
- first_name: Maria
  full_name: de Fatima Andrade, Maria
  last_name: de Fatima Andrade
- first_name: Louisa
  full_name: Emmons, Louisa
  last_name: Emmons
- first_name: Guy
  full_name: Brasseur, Guy
  last_name: Brasseur
citation:
  ama: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, et al. A century of vehicular
    emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality.
    <i>Environmental Science &#38;amp; Technology</i>. 2026. doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>'
  apa: 'Ibarra-Espinosa, S., Dias de Freitas, E., Gaubert, B., Lichtig, P., Ropkins,
    K., da Silva, I., … Brasseur, G. (2026). A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality. <i>Environmental Science
    &#38;amp; Technology</i>. American Chemical Society. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>'
  chicago: 'Ibarra-Espinosa, Sergio, Edmilson Dias de Freitas, Benjamin Gaubert, Pablo
    Lichtig, Karl Ropkins, Iara da Silva, Guilherme Martins Pereira, et al. “A Century
    of Vehicular Emissions in Brazil: Unveiling the Impacts of Unique Fuel Mix on
    Air Quality.” <i>Environmental Science &#38;amp; Technology</i>. American Chemical
    Society, 2026. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>.'
  ieee: 'S. Ibarra-Espinosa <i>et al.</i>, “A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality,” <i>Environmental Science
    &#38;amp; Technology</i>. American Chemical Society, 2026.'
  ista: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, Lichtig P, Ropkins K, da
    Silva I, Martins Pereira G, Schuch D, Nascimento J, Hoinaski L, Martins LD, Gavidia-Calderón
    M, Vara-Vela A, Toledo de Almeida Albuquerque T, Ynoue RY, Diez S, Mera Z, Casallas
    Garcia A, Vallejo F, Diaz V, Pedruzzi R, Abrutzky R, Franco MA, Huneeus N, Jorquera
    H, Belalcázar-Cerón LC, Rojas NY, de Fatima Andrade M, Emmons L, Brasseur G. 2026.
    A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel
    mix on air quality. Environmental Science &#38;amp; Technology., 5c08400.'
  mla: 'Ibarra-Espinosa, Sergio, et al. “A Century of Vehicular Emissions in Brazil:
    Unveiling the Impacts of Unique Fuel Mix on Air Quality.” <i>Environmental Science
    &#38;amp; Technology</i>, 5c08400, American Chemical Society, 2026, doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>.'
  short: S. Ibarra-Espinosa, E. Dias de Freitas, B. Gaubert, P. Lichtig, K. Ropkins,
    I. da Silva, G. Martins Pereira, D. Schuch, J. Nascimento, L. Hoinaski, L.D. Martins,
    M. Gavidia-Calderón, A. Vara-Vela, T. Toledo de Almeida Albuquerque, R.Y. Ynoue,
    S. Diez, Z. Mera, A. Casallas Garcia, F. Vallejo, V. Diaz, R. Pedruzzi, R. Abrutzky,
    M.A. Franco, N. Huneeus, H. Jorquera, L.C. Belalcázar-Cerón, N.Y. Rojas, M. de
    Fatima Andrade, L. Emmons, G. Brasseur, Environmental Science &#38;amp; Technology
    (2026).
date_created: 2026-02-09T06:54:10Z
date_published: 2026-02-04T00:00:00Z
date_updated: 2026-02-16T10:33:07Z
day: '04'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1021/acs.est.5c08400
ec_funded: 1
external_id:
  pmid:
  - '41636708'
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Environmental Science &amp; Technology
publication_identifier:
  eissn:
  - 1520-5851
  issn:
  - 0013-936X
publication_status: epub_ahead
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A century of vehicular emissions in Brazil: Unveiling the impacts of unique
  fuel mix on air quality'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21212'
abstract:
- lang: eng
  text: "Malignant glioma is incurable. Using a mouse genetic mosaic system to generate
    sporadic Trp53,Nf1-null OPCs, we previously identified oligodendrocyte precursor
    cell (OPC) as a cell-of-origin of glioma. Here, we report that pre-malignant Trp53,Nf1-null
    OPCs outcompete wildtype counterparts during their expansion. Blocking competition
    by mutating/strengthening wildtype OPCs impeded both pre-malignant progression
    and malignant expansion of glioma.\r\n\r\n“In-tissue” phosphoproteomic profiling
    revealed an enrichment of phosphopeptides related to RNA splicing and protein
    translation at the peak of cell competition, suggesting that competitiveness may
    stem from unique protein species. Among candidates was mTORC1, whose pharmacological
    inhibition or genetic disruption resulted in a loss of competitiveness in our
    mouse model. Finally, analysis of patient biopsies and interrogating the role
    of individual gliomagenic mutations in OPC competition supported its relevance
    in human gliomas. Together, these findings identified the driving role of competitive
    interactions among OPCs in gliomagenesis, and suggest unconventional therapeutic
    strategies to target this process."
acknowledgement: "We thank Dr. Wenjie Liu for providing critical feedback on the manuscript.
  We also thank Dr.\r\nPat Pramoonjago at the Biorepository and Tissue Research Facility,
  and Hope Davis at the\r\nvivarium for their assistance on the project. These Core
  Facilities are supported by UVA Cancer\r\nCenter grant #P30-CA044579. We are grateful
  to Dr. Jonathan A. Epstein for providing the\r\nNf1GRD/+ mouse strain (https://pubmed.ncbi.nlm.nih.gov/26460546/).
  This work was partly\r\nsupported by the National Institute of Neurological Diseases
  and Stroke R21 NS125479-01A1\r\n(H.Z.), American Cancer Society Institutional Research
  Grant to the University of Virginia\r\n(Y.J.), the National Natural Science Foundation
  of China #82072787 (M.Y.), the National\r\nCancer Institute U54 CA238114 (F.W.),
  U01 CA284193 (K.M.N.), and U54 CA274499 (K.A.J.,\r\nM.F-S.), the National institute
  of General Medical Sciences R35 GM133404 (M.F-S.), the Dr.\r\nMiriam and Sheldon
  G. Adelson Medical Research Foundation (H.I.K., S.A.G.), the National\r\nCenter
  for Advancing Translational Sciences KL2TR001882 (K.S.P.), Tower Cancer Career Development
  Grant (K.S.P.), McKnight Neurobiology of Brain Disorders Grant (K.S.P.). The\r\ncontent
  is solely the responsibility of the authors and does not necessarily represent the
  official\r\nviews of the National Institutes of Health. Illustrations in this manuscript
  were created with\r\nBioRender (BioRender.com)."
article_processing_charge: No
author:
- first_name: Ying
  full_name: Jiang, Ying
  last_name: Jiang
- first_name: Ryuhjin
  full_name: Ahn, Ryuhjin
  last_name: Ahn
- first_name: Arthur
  full_name: Huang, Arthur
  last_name: Huang
- first_name: Phillippe P.
  full_name: Gonzalez, Phillippe P.
  last_name: Gonzalez
- first_name: Jungeun
  full_name: Kim, Jungeun
  last_name: Kim
- first_name: Guoxin
  full_name: Zhang, Guoxin
  last_name: Zhang
- first_name: Zihao
  full_name: Liu, Zihao
  last_name: Liu
- first_name: Zhenqiang
  full_name: He, Zhenqiang
  last_name: He
- first_name: Lindsey
  full_name: Dudley, Lindsey
  last_name: Dudley
- first_name: Kunal S.
  full_name: Patel, Kunal S.
  last_name: Patel
- first_name: Godfrey A.
  full_name: Dzhivhuho, Godfrey A.
  last_name: Dzhivhuho
- first_name: Sam
  full_name: Crowl, Sam
  last_name: Crowl
- first_name: Piotr
  full_name: Przanowski, Piotr
  last_name: Przanowski
- first_name: Luisa Quesada
  full_name: Camacho, Luisa Quesada
  last_name: Camacho
- first_name: Sijie
  full_name: Hao, Sijie
  last_name: Hao
- first_name: Jianhao
  full_name: Zeng, Jianhao
  last_name: Zeng
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Mohammad
  full_name: Fallahi-Sichani, Mohammad
  last_name: Fallahi-Sichani
- first_name: Kevin A.
  full_name: Janes, Kevin A.
  last_name: Janes
- first_name: Kristen M.
  full_name: Naegle, Kristen M.
  last_name: Naegle
- first_name: Marie-Louise
  full_name: Hammarskjold, Marie-Louise
  last_name: Hammarskjold
- first_name: Steven A.
  full_name: Goldman, Steven A.
  last_name: Goldman
- first_name: Harley I.
  full_name: Kornblum, Harley I.
  last_name: Kornblum
- first_name: Maojin
  full_name: Yao, Maojin
  last_name: Yao
- first_name: Forest
  full_name: White, Forest
  last_name: White
- first_name: Hui
  full_name: Zong, Hui
  last_name: Zong
citation:
  ama: Jiang Y, Ahn R, Huang A, et al. Critical role of cell competition in gliomagenesis.
    <i>bioRxiv</i>. 2026. doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>
  apa: Jiang, Y., Ahn, R., Huang, A., Gonzalez, P. P., Kim, J., Zhang, G., … Zong,
    H. (2026). Critical role of cell competition in gliomagenesis. <i>bioRxiv</i>.
    <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>
  chicago: Jiang, Ying, Ryuhjin Ahn, Arthur Huang, Phillippe P. Gonzalez, Jungeun
    Kim, Guoxin Zhang, Zihao Liu, et al. “Critical Role of Cell Competition in Gliomagenesis.”
    <i>BioRxiv</i>, 2026. <a href="https://doi.org/10.64898/2026.01.15.699808">https://doi.org/10.64898/2026.01.15.699808</a>.
  ieee: Y. Jiang <i>et al.</i>, “Critical role of cell competition in gliomagenesis,”
    <i>bioRxiv</i>. 2026.
  ista: Jiang Y, Ahn R, Huang A, Gonzalez PP, Kim J, Zhang G, Liu Z, He Z, Dudley
    L, Patel KS, Dzhivhuho GA, Crowl S, Przanowski P, Camacho LQ, Hao S, Zeng J, Hippenmeyer
    S, Fallahi-Sichani M, Janes KA, Naegle KM, Hammarskjold M-L, Goldman SA, Kornblum
    HI, Yao M, White F, Zong H. 2026. Critical role of cell competition in gliomagenesis.
    bioRxiv, <a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  mla: Jiang, Ying, et al. “Critical Role of Cell Competition in Gliomagenesis.” <i>BioRxiv</i>,
    2026, doi:<a href="https://doi.org/10.64898/2026.01.15.699808">10.64898/2026.01.15.699808</a>.
  short: Y. Jiang, R. Ahn, A. Huang, P.P. Gonzalez, J. Kim, G. Zhang, Z. Liu, Z. He,
    L. Dudley, K.S. Patel, G.A. Dzhivhuho, S. Crowl, P. Przanowski, L.Q. Camacho,
    S. Hao, J. Zeng, S. Hippenmeyer, M. Fallahi-Sichani, K.A. Janes, K.M. Naegle,
    M.-L. Hammarskjold, S.A. Goldman, H.I. Kornblum, M. Yao, F. White, H. Zong, BioRxiv
    (2026).
date_created: 2026-02-10T12:55:55Z
date_published: 2026-01-16T00:00:00Z
date_updated: 2026-02-16T10:12:42Z
day: '16'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.64898/2026.01.15.699808
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.01.15.699808
month: '01'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: published
status: public
title: Critical role of cell competition in gliomagenesis
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21217'
abstract:
- lang: eng
  text: This study investigates the mechanisms driving clustered convection and the
    breakdown of the Intertropical Convergence Zone (ITCZ) over the Western Pacific
    Warm Pool using high‐resolution cloud‐resolving simulations and machine‐learning
    sensitivity experiments. Results show that ITCZ breakdown episodes, marked by
    spatially homogeneous convection and weakened meridional moisture gradients, are
    triggered primarily by anomalous moisture advection linked to the equatorial Rossby‐wave
    activity. While large‐scale moisture advection regulates the background convective
    state strongly, it is the surface and low‐level meridional winds that dominate
    transitions between clustered and random convection. Simulations demonstrate that
    moisture alone can sustain convective clustering, but breakdown episodes are more
    persistent and widespread when coupled with southerly meridional advection. These
    findings confirm that wave‐driven advection acts as a regulatory mechanism, periodically
    disrupting convective clustering and reshaping the meridional moisture gradient.
    This modulation of organization by wave‐induced breakdown events is critical for
    understanding tropical convection variability and its implications for the climate
    system.
acknowledgement: This article is based on chapter 5 of the PhD thesis of A. Casallas.
  The authors thank Graziano Giuliani for discussions on the boundary-condition experiments.
  A. Casallas was supported by a PhD fellowship awarded by the Abdus Salam International
  Centre for Theoretical Physics. A. Casallas also acknowledges support by the European
  Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie
  grant agreement No 101034413. C. Muller acknowledges funding from the European Research
  Council (ERC) under the European Union's Horizon 2020 research and innovation program
  (Project CLUSTER, Grant Agreement No. 805041). The authors gratefully acknowledge
  Daniel Hernández-Deckers, Lokahith Agasthya, Chris Holloway, and Paolina Cerlini
  for their valuable feedback and insightful discussions. They are especially thankful
  to Bety Pechacova for suggesting the use of SHAP to complement their analysis. They
  also thank the two anonymous reviewers for their constructive comments, which improved
  the quality and clarity of the article significantly. Open Access funding provided
  by Institute of Science and Technology Austria/KEMÖ.
article_number: e70131
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Adrian
  full_name: Mark Tompkins, Adrian
  last_name: Mark Tompkins
- first_name: Caroline J
  full_name: Muller, Caroline J
  id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
  last_name: Muller
  orcid: 0000-0001-5836-5350
citation:
  ama: Casallas Garcia A, Mark Tompkins A, Muller CJ. Moisture and wind effects of
    Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events.
    <i>Quarterly Journal of the Royal Meteorological Society</i>. 2026. doi:<a href="https://doi.org/10.1002/qj.70131">10.1002/qj.70131</a>
  apa: Casallas Garcia, A., Mark Tompkins, A., &#38; Muller, C. J. (2026). Moisture
    and wind effects of Rossby waves on Western Pacific Intertropical Convergence
    Zone breakdown events. <i>Quarterly Journal of the Royal Meteorological Society</i>.
    Wiley. <a href="https://doi.org/10.1002/qj.70131">https://doi.org/10.1002/qj.70131</a>
  chicago: Casallas Garcia, Alejandro, Adrian Mark Tompkins, and Caroline J Muller.
    “Moisture and Wind Effects of Rossby Waves on Western Pacific Intertropical Convergence
    Zone Breakdown Events.” <i>Quarterly Journal of the Royal Meteorological Society</i>.
    Wiley, 2026. <a href="https://doi.org/10.1002/qj.70131">https://doi.org/10.1002/qj.70131</a>.
  ieee: A. Casallas Garcia, A. Mark Tompkins, and C. J. Muller, “Moisture and wind
    effects of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown
    events,” <i>Quarterly Journal of the Royal Meteorological Society</i>. Wiley,
    2026.
  ista: Casallas Garcia A, Mark Tompkins A, Muller CJ. 2026. Moisture and wind effects
    of Rossby waves on Western Pacific Intertropical Convergence Zone breakdown events.
    Quarterly Journal of the Royal Meteorological Society., e70131.
  mla: Casallas Garcia, Alejandro, et al. “Moisture and Wind Effects of Rossby Waves
    on Western Pacific Intertropical Convergence Zone Breakdown Events.” <i>Quarterly
    Journal of the Royal Meteorological Society</i>, e70131, Wiley, 2026, doi:<a href="https://doi.org/10.1002/qj.70131">10.1002/qj.70131</a>.
  short: A. Casallas Garcia, A. Mark Tompkins, C.J. Muller, Quarterly Journal of the
    Royal Meteorological Society (2026).
corr_author: '1'
date_created: 2026-02-12T10:13:02Z
date_published: 2026-02-12T00:00:00Z
date_updated: 2026-02-16T10:19:52Z
day: '12'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1002/qj.70131
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/qj.70131
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
  call_identifier: H2020
  grant_number: '805041'
  name: Organization of CLoUdS, and implications of Tropical  cyclones and for the
    Energetics of the tropics, in current and waRming climate
publication: Quarterly Journal of the Royal Meteorological Society
publication_identifier:
  eissn:
  - 1477-870X
  issn:
  - 0035-9009
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Moisture and wind effects of Rossby waves on Western Pacific Intertropical
  Convergence Zone breakdown events
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21230'
abstract:
- lang: eng
  text: Asteroseismology is the study of the interior physics and structure of stars
    using their pulsations. It is applicable to stars across the Hertzsprung–Russell
    (HR) diagram and a powerful technique not only to measure masses, radii, and ages
    but also directly constrain interior rotation, chemical mixing, and magnetism.
    This is because a star's self-excited pulsation modes are sensitive to its structure.
    Asteroseismology generally requires long-duration and high-precision time-series
    data. The method of forward asteroseismic modeling, which is the statistical comparison
    of observed pulsation mode frequencies to theoretically predicted pulsation frequencies
    calculated from a grid of models, provides precise constraints for calibrating
    various transport phenomena. In this introduction to asteroseismology, we provide
    an overview of its principles, and the typical data sets and methodologies used
    to constrain stellar interiors. Finally, we present key highlights of asteroseismic
    results from across the HR diagram, and conclude with ongoing challenges and future
    prospects for this ever-expanding field within stellar astrophysics.
article_processing_charge: No
arxiv: 1
author:
- first_name: Dominic M.
  full_name: Bowman, Dominic M.
  last_name: Bowman
- first_name: Lisa Annabelle
  full_name: Bugnet, Lisa Annabelle
  id: d9edb345-f866-11ec-9b37-d119b5234501
  last_name: Bugnet
  orcid: 0000-0003-0142-4000
citation:
  ama: 'Bowman DM, Bugnet LA. Asteroseismology. In: Mandel I, ed. <i>Encyclopedia
    of Astrophysics</i>. Vol 2. Elsevier; 2026:133-153. doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>'
  apa: Bowman, D. M., &#38; Bugnet, L. A. (2026). Asteroseismology. In I. Mandel (Ed.),
    <i>Encyclopedia of Astrophysics</i> (Vol. 2, pp. 133–153). Elsevier. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>
  chicago: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” In <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, 2:133–53. Elsevier, 2026. <a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">https://doi.org/10.1016/b978-0-443-21439-4.00036-5</a>.
  ieee: D. M. Bowman and L. A. Bugnet, “Asteroseismology,” in <i>Encyclopedia of Astrophysics</i>,
    vol. 2, I. Mandel, Ed. Elsevier, 2026, pp. 133–153.
  ista: 'Bowman DM, Bugnet LA. 2026.Asteroseismology. In: Encyclopedia of Astrophysics.
    vol. 2, 133–153.'
  mla: Bowman, Dominic M., and Lisa Annabelle Bugnet. “Asteroseismology.” <i>Encyclopedia
    of Astrophysics</i>, edited by Ilya Mandel, vol. 2, Elsevier, 2026, pp. 133–53,
    doi:<a href="https://doi.org/10.1016/b978-0-443-21439-4.00036-5">10.1016/b978-0-443-21439-4.00036-5</a>.
  short: D.M. Bowman, L.A. Bugnet, in:, I. Mandel (Ed.), Encyclopedia of Astrophysics,
    Elsevier, 2026, pp. 133–153.
date_created: 2026-02-16T10:43:01Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-02-17T11:05:20Z
day: '01'
department:
- _id: LiBu
doi: 10.1016/b978-0-443-21439-4.00036-5
editor:
- first_name: Ilya
  full_name: Mandel, Ilya
  last_name: Mandel
external_id:
  arxiv:
  - '2410.01715'
intvolume: '         2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2410.01715
month: '01'
oa: 1
oa_version: Preprint
page: 133-153
publication: Encyclopedia of Astrophysics
publication_identifier:
  isbn:
  - '9780443214400'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Asteroseismology
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21231'
abstract:
- lang: eng
  text: To assess cell migration in complex spatial environments, microfabricated
    chips, such as mazes and pillar forests, are routinely used to impose spatial
    and mechanical constraints, and cell trajectories are followed within these structures
    by advanced imaging techniques. In systems mechanobiology, computational models
    serve as essential tools to uncover how physical geometry influences intracellular
    dynamics; however, decoding such complex behaviors requires advanced inference
    techniques. Here, we integrated experimental observations of dendritic cell migration
    in a geometrically constrained microenvironment into a Cellular Potts model. We
    demonstrated that these spatial constraints modulate the motility dynamics, including
    speed and directional changes. We show that classical summary statistics, such
    as mean squared displacement and turning angle distributions, can resolve key
    mechanistic features but fail to extract richer spatiotemporal patterns, limiting
    accurate parameter inference. To solve this, we applied neural posterior estimation
    with in-the-loop learning of summary features. This learned summary representation
    of the data enables robust and flexible parameter inference, providing a data-driven
    framework for model calibration and advancing quantitative analysis of cell migration
    in structured microenvironments.
acknowledgement: 'This work was supported by the German Federal Ministry of Education
  and Research (BMBF) (EMUNE/031L0293C), the European Union via the ERC grant INTEGRATE,
  grant agreement number 101126146, and under Germany’s Excellence Strategy by the
  Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (EXC 2047—390685813,
  EXC 2151—390873048, FOR5775 — 533863915, and 524747443), the University of Bonn
  via the Schlegel Professorship of J.H., and the returning experts fellowship of
  the Ministry of Innovation, Science, and Research of North-Rhine-Westphalia (AZ:
  421-8.03.03.02-137069). J.M. is a member of the Nanofabrication Facility and is
  supported by the Institute of Science and Technology Austria. E.K. acknowledges
  the TRA Life and Health (University of Bonn) as part of the Excellence Strategy
  of the federal and state governments. The authors thank Laeschkir Würthner for his
  insightful comments on the implementation of the authors’ model. The views and opinions
  expressed are those of the authors only and do not necessarily reflect those of
  the funding agencies. Parts of Fig. 1 were created using BioRender. Open Access
  funding enabled and organized by Projekt DEAL.'
article_number: '20'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jonas
  full_name: Arruda, Jonas
  last_name: Arruda
- first_name: Emad
  full_name: Alamoudi, Emad
  last_name: Alamoudi
- first_name: Robert
  full_name: Mueller, Robert
  last_name: Mueller
- first_name: Marc
  full_name: Vaisband, Marc
  last_name: Vaisband
- first_name: Ronja
  full_name: Molkenbur, Ronja
  last_name: Molkenbur
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Eva
  full_name: Kiermaier, Eva
  last_name: Kiermaier
- first_name: Jan
  full_name: Hasenauer, Jan
  last_name: Hasenauer
citation:
  ama: Arruda J, Alamoudi E, Mueller R, et al. Simulation-based inference of cell
    migration dynamics in complex spatial environments. <i>npj Systems Biology and
    Applications</i>. 2026;12. doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>
  apa: Arruda, J., Alamoudi, E., Mueller, R., Vaisband, M., Molkenbur, R., Merrin,
    J., … Hasenauer, J. (2026). Simulation-based inference of cell migration dynamics
    in complex spatial environments. <i>Npj Systems Biology and Applications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>
  chicago: Arruda, Jonas, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur,
    Jack Merrin, Eva Kiermaier, and Jan Hasenauer. “Simulation-Based Inference of
    Cell Migration Dynamics in Complex Spatial Environments.” <i>Npj Systems Biology
    and Applications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41540-026-00648-9">https://doi.org/10.1038/s41540-026-00648-9</a>.
  ieee: J. Arruda <i>et al.</i>, “Simulation-based inference of cell migration dynamics
    in complex spatial environments,” <i>npj Systems Biology and Applications</i>,
    vol. 12. Springer Nature, 2026.
  ista: Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier
    E, Hasenauer J. 2026. Simulation-based inference of cell migration dynamics in
    complex spatial environments. npj Systems Biology and Applications. 12, 20.
  mla: Arruda, Jonas, et al. “Simulation-Based Inference of Cell Migration Dynamics
    in Complex Spatial Environments.” <i>Npj Systems Biology and Applications</i>,
    vol. 12, 20, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41540-026-00648-9">10.1038/s41540-026-00648-9</a>.
  short: J. Arruda, E. Alamoudi, R. Mueller, M. Vaisband, R. Molkenbur, J. Merrin,
    E. Kiermaier, J. Hasenauer, Npj Systems Biology and Applications 12 (2026).
date_created: 2026-02-16T10:44:31Z
date_published: 2026-02-05T00:00:00Z
date_updated: 2026-02-23T10:10:10Z
day: '05'
ddc:
- '570'
department:
- _id: NanoFab
doi: 10.1038/s41540-026-00648-9
external_id:
  pmid:
  - '41611727'
file:
- access_level: open_access
  checksum: 99b2e6bbaaedf45f22e07751948669f5
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:09:03Z
  date_updated: 2026-02-23T10:09:03Z
  file_id: '21346'
  file_name: 2026_npjSysBioApp_Arruda.pdf
  file_size: 10217687
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:09:03Z
has_accepted_license: '1'
intvolume: '        12'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Systems Biology and Applications
publication_identifier:
  eissn:
  - 2056-7189
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simulation-based inference of cell migration dynamics in complex spatial environments
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21232'
abstract:
- lang: eng
  text: "<jats:title>Abstract</jats:title>\r\n                  <jats:p>In this paper,
    we consider a simple class of stratified spaces – 2-complexes. We present an algorithm
    that learns the abstract structure of an embedded 2-complex from a point cloud
    sampled from it. We use tools and inspiration from computational geometry, algebraic
    topology, and topological data analysis and prove the correctness of the identified
    abstract structure under assumptions on the embedding.</jats:p>"
acknowledgement: The author would like to thank Kate Turner, Chris Williams, Jonathan
  Spreer, Stephan Tillmann, Vanessa Robins, Vigleik Angeltveit, Martin Helmer, and
  James Morgan for very helpful discussions; and thanks Sara Kališnik Hintz and Paul
  Bendich for comments on an earlier version. Additonally, the author would like to
  thank both reviewers for their very insightful and helpful comments, without which
  the paper would be infinitely less coherent than it currently is. Open access funding
  provided by Institute of Science and Technology (IST Austria). The work in this
  paper was supported by an Australian Federal Government Grant, 2019-2022, Stratified
  Space Learning.
article_number: '17'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Yossi
  full_name: Bleile, Yossi
  id: 920a7385-7995-11ef-9bfd-8c434cd8f3c2
  last_name: Bleile
  orcid: 0000-0002-4861-9174
citation:
  ama: 'Bleile Y. Towards stratified space learning: 2-complexes. <i>La Matematica</i>.
    2026;5. doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>'
  apa: 'Bleile, Y. (2026). Towards stratified space learning: 2-complexes. <i>La Matematica</i>.
    Springer Nature. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>'
  chicago: 'Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La
    Matematica</i>. Springer Nature, 2026. <a href="https://doi.org/10.1007/s44007-025-00183-9">https://doi.org/10.1007/s44007-025-00183-9</a>.'
  ieee: 'Y. Bleile, “Towards stratified space learning: 2-complexes,” <i>La Matematica</i>,
    vol. 5. Springer Nature, 2026.'
  ista: 'Bleile Y. 2026. Towards stratified space learning: 2-complexes. La Matematica.
    5, 17.'
  mla: 'Bleile, Yossi. “Towards Stratified Space Learning: 2-Complexes.” <i>La Matematica</i>,
    vol. 5, 17, Springer Nature, 2026, doi:<a href="https://doi.org/10.1007/s44007-025-00183-9">10.1007/s44007-025-00183-9</a>.'
  short: Y. Bleile, La Matematica 5 (2026).
corr_author: '1'
date_created: 2026-02-16T10:44:44Z
date_published: 2026-02-08T00:00:00Z
date_updated: 2026-02-23T10:20:10Z
day: '08'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s44007-025-00183-9
external_id:
  arxiv:
  - '2305.02724'
file:
- access_level: open_access
  checksum: 6cae2efb47b025af22a8539c606a4e09
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:18:52Z
  date_updated: 2026-02-23T10:18:52Z
  file_id: '21347'
  file_name: 2026_LaMatematica_Bleile.pdf
  file_size: 15051582
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:18:52Z
has_accepted_license: '1'
intvolume: '         5'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: La Matematica
publication_identifier:
  issn:
  - 2730-9657
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Towards stratified space learning: 2-complexes'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21233'
abstract:
- lang: eng
  text: Potential self-perpetuating dieback of the Amazon rain forest has been a topic
    of concern. The concern is that initial deforestation could critically impair
    the forest’s water recycling capacities, further harming the remaining forest
    through reduced annual precipitation. Many studies have focused on annual mean
    precipitation changes, due to its widespread perception as a central control on
    the Amazon rain forest’s stability. However, the impact of deforestation goes
    beyond changes in the annual mean precipitation. Yet, global coarse-resolution
    climate models are not well suited to investigate changes in short-duration and
    localized events due to their coarse resolution. Here, we circumvent these issues
    by analyzing a full-deforestation scenario simulated by a global storm-resolving
    model. We focus on changes in the tail of the hourly distribution of precipitation,
    temperature, and wind. Hourly precipitation becomes more extreme in the absence
    of the forest than in an intact forest, with an increased occurrence of both no
    rain and intense rainfall. These changes are driven by enhanced moisture convergence
    that strengthens vertical velocity. On average, the near-surface temperature rises
    significantly by about 3.84 °C, and the daily minimum temperature after deforestation
    becomes similar to the daily maximum temperature before deforestation. Except
    for wet-bulb temperature, human heat stress indicators shift to more severe levels,
    with implications for health and a significant reduction in work productivity.
    Finally, the mean 10 m wind speed intensifies by a factor of four, with the 99th
    percentile wind speed doubling. To summarize, our findings, while based on an
    idealized case, provide a stark warning of the effects of continuing deforestation
    of the Amazon.
acknowledgement: AY acknowledges funding by the CLICCS centre of excellence subproject
  A3 funded by DFG. We thank the German Climate Computing Center DKRZ for providing
  computing resources and the Integrated Climate Data Center (ICDC), the Center for
  Earth System Research and Sustainability (CEN), University of Hamburg, for supporting
  the IMERG data. In addition, we would like to thank Jana Sillmann for suggesting
  the analysis of heat stress indices and Keno Riechers for providing a thorough internal
  review of the initial manuscript at the Max Planck Institute for Meteorology. Open
  Access funding is enabled and organized by Projekt DEAL. This research has been
  supported by the Deutsche Forschungsgemeinschaft (grant no. CLICCS 390683824 (A3)).
  The article processing charges for this open-access publication were covered by
  the Max Planck Society.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Arim
  full_name: Yoon, Arim
  last_name: Yoon
- first_name: Cathy
  full_name: Hohenegger, Cathy
  last_name: Hohenegger
- first_name: Jiawei
  full_name: Bao, Jiawei
  id: bb9a7399-fefd-11ed-be3c-ae648fd1d160
  last_name: Bao
- first_name: Lukas
  full_name: Brunner, Lukas
  last_name: Brunner
citation:
  ama: Yoon A, Hohenegger C, Bao J, Brunner L. Extreme events in the Amazon after
    deforestation. <i>Earth System Dynamics</i>. 2026;17(1):167-179. doi:<a href="https://doi.org/10.5194/esd-17-167-2026">10.5194/esd-17-167-2026</a>
  apa: Yoon, A., Hohenegger, C., Bao, J., &#38; Brunner, L. (2026). Extreme events
    in the Amazon after deforestation. <i>Earth System Dynamics</i>. Copernicus GmbH.
    <a href="https://doi.org/10.5194/esd-17-167-2026">https://doi.org/10.5194/esd-17-167-2026</a>
  chicago: Yoon, Arim, Cathy Hohenegger, Jiawei Bao, and Lukas Brunner. “Extreme Events
    in the Amazon after Deforestation.” <i>Earth System Dynamics</i>. Copernicus GmbH,
    2026. <a href="https://doi.org/10.5194/esd-17-167-2026">https://doi.org/10.5194/esd-17-167-2026</a>.
  ieee: A. Yoon, C. Hohenegger, J. Bao, and L. Brunner, “Extreme events in the Amazon
    after deforestation,” <i>Earth System Dynamics</i>, vol. 17, no. 1. Copernicus
    GmbH, pp. 167–179, 2026.
  ista: Yoon A, Hohenegger C, Bao J, Brunner L. 2026. Extreme events in the Amazon
    after deforestation. Earth System Dynamics. 17(1), 167–179.
  mla: Yoon, Arim, et al. “Extreme Events in the Amazon after Deforestation.” <i>Earth
    System Dynamics</i>, vol. 17, no. 1, Copernicus GmbH, 2026, pp. 167–79, doi:<a
    href="https://doi.org/10.5194/esd-17-167-2026">10.5194/esd-17-167-2026</a>.
  short: A. Yoon, C. Hohenegger, J. Bao, L. Brunner, Earth System Dynamics 17 (2026)
    167–179.
date_created: 2026-02-16T10:44:58Z
date_published: 2026-02-04T00:00:00Z
date_updated: 2026-02-23T10:28:48Z
day: '04'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.5194/esd-17-167-2026
file:
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  creator: dernst
  date_created: 2026-02-23T10:26:29Z
  date_updated: 2026-02-23T10:26:29Z
  file_id: '21348'
  file_name: 2026_EarthSystDynam_Yoon.pdf
  file_size: 2068229
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file_date_updated: 2026-02-23T10:26:29Z
has_accepted_license: '1'
intvolume: '        17'
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 167-179
publication: Earth System Dynamics
publication_identifier:
  eissn:
  - 2190-4987
publication_status: published
publisher: Copernicus GmbH
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extreme events in the Amazon after deforestation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21234'
abstract:
- lang: eng
  text: In aged humans and mice, hypobranched glycogen aggregates, known as polyglucosan
    bodies (PGBs), accumulate in hippocampal astrocytes. While PGBs are linked to
    cognitive decline in neurological diseases, they remain largely unstudied in the
    context of typical aging. We show that PGBs arise in autophagy-dysregulated astrocytes
    in the aged hippocampus, with substantial variation among 32 inbred BXD mouse
    strains. Genetic mapping through quantitative trait locus analysis identified
    a major locus (Pgb1) that modulates hippocampal PGB burden. Extensive transcriptomic
    and proteomic datasets were produced for the aged hippocampus of the BXD family
    to investigate the mechanism by which the Pgb1 locus modulates PGB burden. We
    identified that Pgb1 contains allelic Smarcal1 and Usp37 variants and influences
    PGB burden through trans-regulation of mRNA and protein expression levels, including
    abundance of glycogen-mobilizing factor PYGB. Furthermore, comprehensive phenome-wide
    association scans, transcriptomic analyses, and direct behavioral testing demonstrated
    that cognition remains intact despite age-related PGB burden. A record of this
    paper’s transparent peer review process is included in the supplemental information.
acknowledgement: We would like to thank the Summer School Systems Genetics of Neural
  Ageing for bringing us together and spurring our international collaboration. We
  would also like to acknowledge the funding for the Summer School 2022 from the e:Med
  Systems Medicine Program of the BMBF (Bundesministerium für Bildung und Forschung;
  German Ministry of Education and Research) to R.W.O. In addition, we would like
  to thank the FLI imaging core facility for their assistance. A.G.-P. is supported
  by Fundación Séneca, Región de Murcia, Spain (21259/FPI/19). D.E.M.d.B. is financed
  by a Rubicon scholarship (452021116) from the Dutch Research Council (NWO). This
  work was also supported by NIH NIA R01AG070913-01 (R.W.W.), R01AG075813-01 (D.G.A.),
  and R01AG075818 (C.K.). We acknowledge the help of Larry Mobraaten (Jackson Laboratory,
  Bar Harbor, MN) with the BXD strains and U. Obermüller for the help with the histology.
  For the purpose of open access, the authors have applied a CC BY public copyright
  license to all author-accepted manuscripts arising from this submission.
article_number: '101488'
article_processing_charge: No
article_type: original
author:
- first_name: Alicia
  full_name: Gómez-Pascual, Alicia
  last_name: Gómez-Pascual
- first_name: Dow M
  full_name: Glikman, Dow M
  id: ab8acda1-91c1-11f0-aad8-f75d3d6424d8
  last_name: Glikman
- first_name: Hui Xin
  full_name: Ng, Hui Xin
  last_name: Ng
- first_name: James E.
  full_name: Tomkins, James E.
  last_name: Tomkins
- first_name: Lu
  full_name: Lu, Lu
  last_name: Lu
- first_name: Ying
  full_name: Xu, Ying
  last_name: Xu
- first_name: David G.
  full_name: Ashbrook, David G.
  last_name: Ashbrook
- first_name: Catherine
  full_name: Kaczorowski, Catherine
  last_name: Kaczorowski
- first_name: Gerd
  full_name: Kempermann, Gerd
  last_name: Kempermann
- first_name: John
  full_name: Killmar, John
  last_name: Killmar
- first_name: Khyobeni
  full_name: Mozhui, Khyobeni
  last_name: Mozhui
- first_name: Oliver
  full_name: Ohlenschläger, Oliver
  last_name: Ohlenschläger
- first_name: Rudolf
  full_name: Aebersold, Rudolf
  last_name: Aebersold
- first_name: Donald K.
  full_name: Ingram, Donald K.
  last_name: Ingram
- first_name: Evan G.
  full_name: Williams, Evan G.
  last_name: Williams
- first_name: Mathias
  full_name: Jucker, Mathias
  last_name: Jucker
- first_name: Rupert W.
  full_name: Overall, Rupert W.
  last_name: Overall
- first_name: Robert W.
  full_name: Williams, Robert W.
  last_name: Williams
- first_name: Dennis E.M.
  full_name: de Bakker, Dennis E.M.
  last_name: de Bakker
citation:
  ama: Gómez-Pascual A, Glikman DM, Ng HX, et al. The Smarcal1-Usp37 locus modulates
    glycogen aggregation in astrocytes of the aged hippocampus. <i>Cell Systems</i>.
    2026;17(2). doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>
  apa: Gómez-Pascual, A., Glikman, D. M., Ng, H. X., Tomkins, J. E., Lu, L., Xu, Y.,
    … de Bakker, D. E. M. (2026). The Smarcal1-Usp37 locus modulates glycogen aggregation
    in astrocytes of the aged hippocampus. <i>Cell Systems</i>. Elsevier. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>
  chicago: Gómez-Pascual, Alicia, Dow M Glikman, Hui Xin Ng, James E. Tomkins, Lu
    Lu, Ying Xu, David G. Ashbrook, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.cels.2025.101488">https://doi.org/10.1016/j.cels.2025.101488</a>.
  ieee: A. Gómez-Pascual <i>et al.</i>, “The Smarcal1-Usp37 locus modulates glycogen
    aggregation in astrocytes of the aged hippocampus,” <i>Cell Systems</i>, vol.
    17, no. 2. Elsevier, 2026.
  ista: Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski
    C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK,
    Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. 2026. The Smarcal1-Usp37
    locus modulates glycogen aggregation in astrocytes of the aged hippocampus. Cell
    Systems. 17(2), 101488.
  mla: Gómez-Pascual, Alicia, et al. “The Smarcal1-Usp37 Locus Modulates Glycogen
    Aggregation in Astrocytes of the Aged Hippocampus.” <i>Cell Systems</i>, vol.
    17, no. 2, 101488, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.cels.2025.101488">10.1016/j.cels.2025.101488</a>.
  short: A. Gómez-Pascual, D.M. Glikman, H.X. Ng, J.E. Tomkins, L. Lu, Y. Xu, D.G.
    Ashbrook, C. Kaczorowski, G. Kempermann, J. Killmar, K. Mozhui, O. Ohlenschläger,
    R. Aebersold, D.K. Ingram, E.G. Williams, M. Jucker, R.W. Overall, R.W. Williams,
    D.E.M. de Bakker, Cell Systems 17 (2026).
date_created: 2026-02-16T10:45:10Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-23T10:35:01Z
day: '18'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1016/j.cels.2025.101488
external_id:
  pmid:
  - '41633365'
file:
- access_level: open_access
  checksum: 920e8edfd3b8b42f5bb6f86d4c66c54d
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-23T10:32:12Z
  date_updated: 2026-02-23T10:32:12Z
  file_id: '21349'
  file_name: 2026_CellSystems_GomezPascual.pdf
  file_size: 10606778
  relation: main_file
  success: 1
file_date_updated: 2026-02-23T10:32:12Z
has_accepted_license: '1'
intvolume: '        17'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cell Systems
publication_identifier:
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the
  aged hippocampus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21242'
abstract:
- lang: eng
  text: We obtain an asymptotic formula for the number of integral solutions to a
    system of diagonal equations. We obtain an asymptotic formula for the number of
    solutions with variables restricted to smooth numbers as well. We improve the
    required number of variables compared to previous results by incorporating recent
    progress on Waring’s problem and the resolution of the main conjecture in Vinogradov’s
    mean value theorem.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nick
  full_name: Rome, Nick
  last_name: Rome
- first_name: Shuntaro
  full_name: Yamagishi, Shuntaro
  id: 0c3fbc5c-f7a6-11ec-8d70-9485e75b416b
  last_name: Yamagishi
citation:
  ama: Rome N, Yamagishi S. Integral solutions to systems of diagonal equations. <i>Pacific
    Journal of Mathematics</i>. 2026;340(1):179-198. doi:<a href="https://doi.org/10.2140/pjm.2026.340.179">10.2140/pjm.2026.340.179</a>
  apa: Rome, N., &#38; Yamagishi, S. (2026). Integral solutions to systems of diagonal
    equations. <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers.
    <a href="https://doi.org/10.2140/pjm.2026.340.179">https://doi.org/10.2140/pjm.2026.340.179</a>
  chicago: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
    Equations.” <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers,
    2026. <a href="https://doi.org/10.2140/pjm.2026.340.179">https://doi.org/10.2140/pjm.2026.340.179</a>.
  ieee: N. Rome and S. Yamagishi, “Integral solutions to systems of diagonal equations,”
    <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1. Mathematical Sciences
    Publishers, pp. 179–198, 2026.
  ista: Rome N, Yamagishi S. 2026. Integral solutions to systems of diagonal equations.
    Pacific Journal of Mathematics. 340(1), 179–198.
  mla: Rome, Nick, and Shuntaro Yamagishi. “Integral Solutions to Systems of Diagonal
    Equations.” <i>Pacific Journal of Mathematics</i>, vol. 340, no. 1, Mathematical
    Sciences Publishers, 2026, pp. 179–98, doi:<a href="https://doi.org/10.2140/pjm.2026.340.179">10.2140/pjm.2026.340.179</a>.
  short: N. Rome, S. Yamagishi, Pacific Journal of Mathematics 340 (2026) 179–198.
date_created: 2026-02-16T15:17:27Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-02-17T11:43:14Z
day: '01'
department:
- _id: TiBr
doi: 10.2140/pjm.2026.340.179
external_id:
  arxiv:
  - '2406.09256'
intvolume: '       340'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2406.09256
month: '01'
oa: 1
oa_version: Preprint
page: 179-198
publication: Pacific Journal of Mathematics
publication_identifier:
  eissn:
  - 1945-5844
  issn:
  - 0030-8730
publication_status: published
publisher: Mathematical Sciences Publishers
quality_controlled: '1'
status: public
title: Integral solutions to systems of diagonal equations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 340
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21273'
abstract:
- lang: eng
  text: In this paper we examine how porosity fluctuations affect the hydrodynamic
    permeability of a porous matrix or membrane. We introduce a fluctuating Darcy
    model, which couples the Navier-Stokes equation to the space- and time-dependent
    porosity fluctuations via a Darcy friction term. Using a perturbative approach,
    a Dyson equation for hydrodynamic fluctuations is derived and solved to express
    the permeability in terms of the matrix fluctuation spectrum. Surprisingly, the
    model reveals strong modifications of the fluid permeability in fluctuating matrices
    compared to static ones. Applications to various matrix excitation models, the
    breathing matrix, phonons, and active forcing, highlight the significant influence
    of matrix fluctuations on fluid transport, offering insights for optimizing membrane
    design for separation applications.
acknowledgement: "The authors acknowledge support from ERC project n-AQUA, Grant Agreement
  No. 101071937.\r\nB.C. and A.S. acknowledge support from the CFM Foundation. B.C.
  acknowledges support from\r\nthe NOMIS Foundation."
article_number: '014201'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Albert
  full_name: Dombret, Albert
  last_name: Dombret
- first_name: Adrien
  full_name: Sutter, Adrien
  last_name: Sutter
- first_name: Baptiste
  full_name: Coquinot, Baptiste
  id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
  last_name: Coquinot
  orcid: 0000-0001-5524-596X
- first_name: Nikita
  full_name: Kavokine, Nikita
  last_name: Kavokine
- first_name: Benoit
  full_name: Coasne, Benoit
  last_name: Coasne
- first_name: Lydéric
  full_name: Bocquet, Lydéric
  last_name: Bocquet
citation:
  ama: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. Hydrodynamic
    permeability of fluctuating porous membranes. <i>Physical Review Fluids</i>. 2026;11(1).
    doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>
  apa: Dombret, A., Sutter, A., Coquinot, B., Kavokine, N., Coasne, B., &#38; Bocquet,
    L. (2026). Hydrodynamic permeability of fluctuating porous membranes. <i>Physical
    Review Fluids</i>. American Physical Society. <a href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>
  chicago: Dombret, Albert, Adrien Sutter, Baptiste Coquinot, Nikita Kavokine, Benoit
    Coasne, and Lydéric Bocquet. “Hydrodynamic Permeability of Fluctuating Porous
    Membranes.” <i>Physical Review Fluids</i>. American Physical Society, 2026. <a
    href="https://doi.org/10.1103/m8h6-1wfk">https://doi.org/10.1103/m8h6-1wfk</a>.
  ieee: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, and L. Bocquet,
    “Hydrodynamic permeability of fluctuating porous membranes,” <i>Physical Review
    Fluids</i>, vol. 11, no. 1. American Physical Society, 2026.
  ista: Dombret A, Sutter A, Coquinot B, Kavokine N, Coasne B, Bocquet L. 2026. Hydrodynamic
    permeability of fluctuating porous membranes. Physical Review Fluids. 11(1), 014201.
  mla: Dombret, Albert, et al. “Hydrodynamic Permeability of Fluctuating Porous Membranes.”
    <i>Physical Review Fluids</i>, vol. 11, no. 1, 014201, American Physical Society,
    2026, doi:<a href="https://doi.org/10.1103/m8h6-1wfk">10.1103/m8h6-1wfk</a>.
  short: A. Dombret, A. Sutter, B. Coquinot, N. Kavokine, B. Coasne, L. Bocquet, Physical
    Review Fluids 11 (2026).
corr_author: '1'
date_created: 2026-02-17T08:10:09Z
date_published: 2026-01-21T00:00:00Z
date_updated: 2026-02-23T12:01:57Z
day: '21'
department:
- _id: MiLe
doi: 10.1103/m8h6-1wfk
external_id:
  arxiv:
  - '2512.11368'
intvolume: '        11'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2512.11368
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review Fluids
publication_identifier:
  eissn:
  - 2469-990X
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Hydrodynamic permeability of fluctuating porous membranes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21275'
abstract:
- lang: eng
  text: DNA methylation is a primary layer of epigenetic modification that plays a
    pivotal role in the regulation of development, aging, and cancer. The concurrent
    activity of opposing enzymes that mediate DNA methylation and demethylation gives
    rise to a biochemical cycle and active turnover of DNA methylation. While the
    ensuing biochemical oscillations have been implicated in the regulation of cell
    differentiation, their functional role and spatiotemporal dynamics are unknown.
    In this work, we demonstrate that chromatin-mediated coupling between these local
    biochemical cycles can lead to the emergence of phase-locked domains, regions
    of locally synchronized turnover activity, whose coarsening is arrested by genomic
    heterogeneity. We introduce a minimal model based on stochastic oscillators with
    constrained long-range and nonreciprocal interactions, shaped by the local chromatin
    organization. Through a combination of analytical theory and stochastic simulations,
    we predict both the degree of synchronization and the typical size of emergent
    phase-locked domains. We qualitatively test these predictions using single-cell
    sequencing data. Our results show that DNA methylation turnover exhibits surprisingly
    rich spatiotemporal patterns that may be used by cells to control cell differentiation.
acknowledgement: This project has received funding from the European Union's Horizon
  2020 research and innovation programme under Grant Agreement No. 950349 and the
  Marie Skłodowska-Curie Grant Agreement No. 101034413. The computations in this paper
  were run in part on the the FASRC Cannon cluster supported by the FAS Division of
  Science Research Computing Group at Harvard University and the cluster of the Max
  Planck Institute for the Physics of Complex Systems.
article_number: '013018'
article_processing_charge: Yes
article_type: original
author:
- first_name: Fabrizio
  full_name: Olmeda, Fabrizio
  id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
  last_name: Olmeda
- first_name: Misha
  full_name: Gupta, Misha
  last_name: Gupta
- first_name: Onurcan
  full_name: Bektas, Onurcan
  last_name: Bektas
- first_name: Steffen
  full_name: Rulands, Steffen
  last_name: Rulands
citation:
  ama: Olmeda F, Gupta M, Bektas O, Rulands S. Spatiotemporal patterns of active epigenetic
    turnover. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>
  apa: Olmeda, F., Gupta, M., Bektas, O., &#38; Rulands, S. (2026). Spatiotemporal
    patterns of active epigenetic turnover. <i>PRX Life</i>. American Physical Society.
    <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>
  chicago: Olmeda, Fabrizio, Misha Gupta, Onurcan Bektas, and Steffen Rulands. “Spatiotemporal
    Patterns of Active Epigenetic Turnover.” <i>PRX Life</i>. American Physical Society,
    2026. <a href="https://doi.org/10.1103/89bj-79g5">https://doi.org/10.1103/89bj-79g5</a>.
  ieee: F. Olmeda, M. Gupta, O. Bektas, and S. Rulands, “Spatiotemporal patterns of
    active epigenetic turnover,” <i>PRX Life</i>, vol. 4. American Physical Society,
    2026.
  ista: Olmeda F, Gupta M, Bektas O, Rulands S. 2026. Spatiotemporal patterns of active
    epigenetic turnover. PRX Life. 4, 013018.
  mla: Olmeda, Fabrizio, et al. “Spatiotemporal Patterns of Active Epigenetic Turnover.”
    <i>PRX Life</i>, vol. 4, 013018, American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/89bj-79g5">10.1103/89bj-79g5</a>.
  short: F. Olmeda, M. Gupta, O. Bektas, S. Rulands, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:17:53Z
date_published: 2026-02-09T00:00:00Z
date_updated: 2026-02-24T06:54:32Z
day: '09'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1103/89bj-79g5
ec_funded: 1
file:
- access_level: open_access
  checksum: df9776422862d1d02c66d98e2d620849
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T06:53:05Z
  date_updated: 2026-02-24T06:53:05Z
  file_id: '21351'
  file_name: 2026_PRXLife_Olmeda.pdf
  file_size: 5857833
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:53:05Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Spatiotemporal patterns of active epigenetic turnover
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21282'
abstract:
- lang: eng
  text: 'Developmental patterning comprises processes that range from purely instructed,
    where external signals specify cell fates, to fully self-organized, where spatial
    patterns emerge autonomously through cellular interactions. We propose that both
    extremes—as well as the continuum of intermediate cases—can be conceptualized
    as information-processing systems, whose operation can be described using “Marr''s
    three levels of analysis”: the computational problem being solved, the algorithms
    employed, and their molecular implementation. At the first level, we argue that
    normative theories, such as information-theoretic optimization principles, provide
    a formalization of the computational problem. At the second level, we show how
    simplified information-processing architectures provide a framework for developmental
    algorithms, which are formalized mathematically using dynamical systems theory.
    At the third level, the implementation of developmental algorithms is described
    by mechanistic biophysical and gene regulatory network models.'
acknowledgement: We thank Edouard Hannezo, Anna Kicheva, Fridtjof Brauns, and all
  members of the Brückner and Tkačik groups for feedback and inspiring discussions.
  This work was supported in part by European Research Council ERC-2023-SyG “Dynatrans”
  Grant No. 101118866 (G.T.). This work was conducted while visiting the Okinawa Institute
  of Science and Technology (OIST) through the Theoretical Sciences Visiting Program
  (TSVP); at the Kavli Institute for Theoretical Physics (KITP) Santa Barbara, supported
  by NSF Grant No. PHY-1748958 and the Gordon and Betty Moore Foundation Grant No.
  2919.02; and at Lucullus, Vienna.
article_number: '017001'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Brückner D, Tkačik G. Marr’s three levels for embryonic development: Information,
    dynamical systems, gene networks. <i>PRX Life</i>. 2026;4. doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>'
  apa: 'Brückner, D., &#38; Tkačik, G. (2026). Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. <i>PRX Life</i>. American Physical
    Society. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>'
  chicago: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic
    Development: Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>.
    American Physical Society, 2026. <a href="https://doi.org/10.1103/fdcf-dkws">https://doi.org/10.1103/fdcf-dkws</a>.'
  ieee: 'D. Brückner and G. Tkačik, “Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks,” <i>PRX Life</i>, vol. 4. American
    Physical Society, 2026.'
  ista: 'Brückner D, Tkačik G. 2026. Marr’s three levels for embryonic development:
    Information, dynamical systems, gene networks. PRX Life. 4, 017001.'
  mla: 'Brückner, David, and Gašper Tkačik. “Marr’s Three Levels for Embryonic Development:
    Information, Dynamical Systems, Gene Networks.” <i>PRX Life</i>, vol. 4, 017001,
    American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/fdcf-dkws">10.1103/fdcf-dkws</a>.'
  short: D. Brückner, G. Tkačik, PRX Life 4 (2026).
corr_author: '1'
date_created: 2026-02-17T08:29:10Z
date_published: 2026-01-23T00:00:00Z
date_updated: 2026-02-24T07:00:16Z
day: '23'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1103/fdcf-dkws
external_id:
  arxiv:
  - '2510.24536'
file:
- access_level: open_access
  checksum: 99ef02dd741c4536eeefd12d409d5269
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T06:57:44Z
  date_updated: 2026-02-24T06:57:44Z
  file_id: '21352'
  file_name: 2026_PRXLife_Brueckner.pdf
  file_size: 1147994
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T06:57:44Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 7bfe6a29-9f16-11ee-852c-c0da5e2045d9
  grant_number: '101118866'
  name: 'Transcription in 4D: the dynamic interplay between chromatin architecture
    and gene expression in developing pseudo-embryos'
publication: PRX Life
publication_identifier:
  eissn:
  - 2835-8279
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: 'Marr''s three levels for embryonic development: Information, dynamical systems,
  gene networks'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21284'
abstract:
- lang: eng
  text: The advantageous characteristics attributed to the 19F nucleus have made it
    a popular target for NMR once again in recent years. Aside from solution NMR,
    an increasing number of studies have been conducted applying solid-state magic-angle-spinning
    NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and
    strong dipolar couplings can be utilized to get structural insights into proteins
    and measure long distances. Despite increasing popularity and promising benefits,
    the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal
    T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic
    doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled
    biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and
    13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected
    MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially
    reduces measurement times of 19F MAS NMR experiments without compromising resolution.
    Additionally, we report the chemical-shift assignments of all four fluorotryptophan
    signals in the 12 × 39 kDa large protein using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
  was supported by the Scientific Service Units (SSU) of Institute of Science and
  Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
  Facility and the Lab Support Facility.
article_processing_charge: No
author:
- first_name: Lea Marie
  full_name: Becker, Lea Marie
  id: 36336939-eb97-11eb-a6c2-c83f1214ca79
  last_name: Becker
  orcid: 0000-0002-6401-5151
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle
    spinning NMR with paramagnetic dopants.” 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>
  apa: Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F
    biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of
    Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>
  chicago: Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of
    Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21284">https://doi.org/10.15479/AT-ISTA-21284</a>.
  ieee: L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and
    Technology Austria, 2026.
  ista: Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular
    magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and
    Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  mla: Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F
    Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute
    of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21284">10.15479/AT-ISTA-21284</a>.
  short: L.M. Becker, P. Schanda, (2026).
contributor:
- contributor_type: researcher
  first_name: Giorgia
  id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
  last_name: Toscano
- contributor_type: researcher
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: researcher
  first_name: Rajkumar
  id: a3089acd-6806-11ee-bacc-f0c7d500ad20
  last_name: Singh
- contributor_type: researcher
  first_name: Undina
  id: bb74f472-ae54-11eb-9835-bc9c22fb1183
  last_name: Guillerm
- contributor_type: researcher
  first_name: Roman
  last_name: Lichtenecker
corr_author: '1'
date_created: 2026-02-17T10:17:14Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-02-18T10:12:49Z
day: '18'
ddc:
- '541'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT-ISTA-21284
file:
- access_level: open_access
  checksum: 2d3105f26be578073b88ee1f2ea0bdb1
  content_type: application/zip
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21285'
  file_name: Research_data.zip
  file_size: 36996027
  relation: main_file
  success: 1
- access_level: open_access
  checksum: e24aebcdb8856cb181cbaa02de020ddb
  content_type: text/plain
  creator: lbecker
  date_created: 2026-02-17T10:11:14Z
  date_updated: 2026-02-17T10:11:14Z
  file_id: '21286'
  file_name: README.txt
  file_size: 1993
  relation: table_of_contents
file_date_updated: 2026-02-17T10:11:14Z
has_accepted_license: '1'
month: '2'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
status: public
title: Research data for "Accelerated 19F biomolecular magic-angle spinning NMR with
  paramagnetic dopants"
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21290'
abstract:
- lang: eng
  text: Gene duplication underlies evolutionary innovation, yet many paralogues remain
    highly similar, raising questions about their functional divergence and physiological
    relevance. The spliceosomal Sm core protein SNRPB and its mammalian-specific paralogue
    SNRPN share over 90% sequence identity, but their distinct expression patterns
    - SNRPB being ubiquitous and SNRPN confined to the brain - suggest specialized
    functions. Why mammals have two different spliceosomes has remained obscure. Here,
    we generated isogenic human cell lines expressing ectopically either SNRPB or
    SNRPN exclusively and found that SNRPN stabilizes transcripts involved in energy
    metabolism and mitochondrial function, leading to increased mitochondrial abundance
    and oxygen consumption. Despite similar spliceosomal interactomes, SNRPN more
    strongly associates with the PRMT5 methylosome complex and exhibits dynamic arginine
    methylation in its C-terminal region that is sensitive to translation inhibition
    and amino acid availability. The SNRPN-dependent transcriptome responds to translation
    inhibition by stabilizing long, intron-rich genes involved in amino acid and energy
    metabolism. Our findings reveal a nutrient-sensitive, methylation-dependent mechanism
    that differentiates the two paralogues. This suggests that SNRPN functions as
    a metabolic-specialized spliceosomal subunit thereby providing tissue-specific
    adaptation of RNA processing in mammals.
acknowledgement: "We thank Oliver Mühlemann and Alex Hofer (University of Bern) for
  sharing SMG inhibitors\r\nand for their expertise in nonsense-mediated mRNA decay
  and Maria Hondele for critical\r\nreading of the manuscript draft. We also thank
  the IMB Genomics Core Facility for assistance\r\nwith library preparation and sequencing,
  Martin Möckel and the IMB Protein Production Core\r\nFacility for providing enzymes
  used in this work, Marton Gelleri together with the IMB\r\nMicroscopy Core Facility
  for support with microscopy and FRAP experiments, Jasmin Cartano\r\nfor proteomics
  sample processing and the IMB Flow Cytometry Core Facility for support. In\r\naddition,
  we thank the Imaging Core Facility (IMCF) and the FACS Core Facility at the\r\nBiozentrum,
  University of Basel, for technical assistance. CIKV acknowledges funding by the\r\nDeutsche
  Forschungsgemeinschaft (DFG, German Research Foundation) - Individual Grant\r\nProject
  no. 513744403, Scientific Network Grant Project no. 531902894, GRK2526 “Genevo”\r\n-
  Project no. 407023052”, GRK2859 (“4R”) - Project no. 491145305, Forschungsinitiative\r\nRheinland-Pfalz
  (ReALity), the EMBO Young Investigator Program (5795), institutional\r\nfunding
  from the Institute of Molecular Biology and funds from the Kanton Basel-Stadt and\r\nBasel-Land
  provided to the Biozentrum of the University Basel. J.H.G.F.G. was part of the\r\n‘Science
  of Healthy Ageing Research Programme’ (SHARP) initiative funded by RhinelandPalatinate’s
  Ministry of Science, Education and Culture. PR is funded by the Biozentrum PhD\r\nFellowships
  Program. MFB received financial support from the intramural High Potentials\r\nGrant
  program of the University Medical Center Mainz, Forschungsinitiative Rheinland-Pfalz\r\n(ReALity)
  and Stiftungen zugunsten der Medizinischen Fakultät der LMU Klinikum (26069).\r\nInstruments
  in the IMB core facilities were supported by funds from the DFG: Laser Scanning\r\nConfocal
  (Leica Stellaris 8 Falcon, funded by the DFG - Project #497669232), Orbitrap Astral
  system (funded by the DFG - Project #524805621) and BD LSRFortessa SOPR is funded
  by\r\nthe DFG - Project #210253511.\r\n"
article_processing_charge: No
author:
- first_name: Feyza
  full_name: Polat Haas, Feyza
  last_name: Polat Haas
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Polina
  full_name: Rusina, Polina
  last_name: Rusina
- first_name: Anusha
  full_name: Gopalan, Anusha
  last_name: Gopalan
- first_name: Hector
  full_name: Fritz, Hector
  last_name: Fritz
- first_name: Azamat
  full_name: Akhmetkaliyev, Azamat
  last_name: Akhmetkaliyev
- first_name: Frank
  full_name: Ruehle, Frank
  last_name: Ruehle
- first_name: Anna
  full_name: Einsiedel, Anna
  last_name: Einsiedel
- first_name: Anna
  full_name: Szczepinska, Anna
  last_name: Szczepinska
- first_name: Fridolin
  full_name: Kielisch, Fridolin
  last_name: Kielisch
- first_name: Jia-Xuan
  full_name: Chen, Jia-Xuan
  last_name: Chen
- first_name: Susanne
  full_name: Nguyen, Susanne
  last_name: Nguyen
- first_name: Thierry
  full_name: Schmidlin, Thierry
  last_name: Schmidlin
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: M. Felicia
  full_name: Bailicata, M. Felicia
  last_name: Bailicata
- first_name: Claudia Isabelle
  full_name: Keller Valsecchi, Claudia Isabelle
  last_name: Keller Valsecchi
citation:
  ama: Polat Haas F, Villalba Requena A, Rusina P, et al. The splicing paralogues
    SNRPB and SNRPN control differential metabolic states. <i>bioRxiv</i>. doi:<a
    href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>
  apa: Polat Haas, F., Villalba Requena, A., Rusina, P., Gopalan, A., Fritz, H., Akhmetkaliyev,
    A., … Keller Valsecchi, C. I. (n.d.). The splicing paralogues SNRPB and SNRPN
    control differential metabolic states. <i>bioRxiv</i>. <a href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>
  chicago: Polat Haas, Feyza, Ana Villalba Requena, Polina Rusina, Anusha Gopalan,
    Hector Fritz, Azamat Akhmetkaliyev, Frank Ruehle, et al. “The Splicing Paralogues
    SNRPB and SNRPN Control Differential Metabolic States.” <i>BioRxiv</i>, n.d. <a
    href="https://doi.org/10.64898/2026.02.11.705284">https://doi.org/10.64898/2026.02.11.705284</a>.
  ieee: F. Polat Haas <i>et al.</i>, “The splicing paralogues SNRPB and SNRPN control
    differential metabolic states.,” <i>bioRxiv</i>. .
  ista: Polat Haas F, Villalba Requena A, Rusina P, Gopalan A, Fritz H, Akhmetkaliyev
    A, Ruehle F, Einsiedel A, Szczepinska A, Kielisch F, Chen J-X, Nguyen S, Schmidlin
    T, Hippenmeyer S, Bailicata MF, Keller Valsecchi CI. The splicing paralogues SNRPB
    and SNRPN control differential metabolic states. bioRxiv, <a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  mla: Polat Haas, Feyza, et al. “The Splicing Paralogues SNRPB and SNRPN Control
    Differential Metabolic States.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.64898/2026.02.11.705284">10.64898/2026.02.11.705284</a>.
  short: F. Polat Haas, A. Villalba Requena, P. Rusina, A. Gopalan, H. Fritz, A. Akhmetkaliyev,
    F. Ruehle, A. Einsiedel, A. Szczepinska, F. Kielisch, J.-X. Chen, S. Nguyen, T.
    Schmidlin, S. Hippenmeyer, M.F. Bailicata, C.I. Keller Valsecchi, BioRxiv (n.d.).
date_created: 2026-02-17T11:35:59Z
date_published: 2026-02-11T00:00:00Z
date_updated: 2026-02-23T11:03:33Z
day: '11'
department:
- _id: SiHi
doi: 10.64898/2026.02.11.705284
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.64898/2026.02.11.705284
month: '02'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
status: public
title: The splicing paralogues SNRPB and SNRPN control differential metabolic states.
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21295'
abstract:
- lang: eng
  text: 'Depending on the type of flow, the transition to turbulence can take one
    of two forms: either turbulence arises from a sequence of instabilities or from
    the spatial proliferation of transiently chaotic domains, a process analogous
    to directed percolation. The former scenario is commonly referred to as a supercritical
    transition and frequently encountered in flows destabilized by body forces, whereas
    the latter subcritical transition is common in shear flows. Both cases are inherently
    continuous in a sense that the transformation from ordered laminar to fully turbulent
    fluid motion is only accomplished gradually with flow speed. Here we show that
    these established transition types do not account for the more general setting
    of shear flows subject to body forces. The combination of the two continuous scenarios
    leads to the attenuation of spatial coupling; with increasing forcing amplitude,
    the transition becomes increasingly sharp and eventually discontinuous. We argue
    that the suppression of laminar–turbulent coexistence and the approach towards
    a discontinuous phase transition potentially apply to a broad range of situations
    including flows subject to, for example, buoyancy, centrifugal or electromagnetic
    forces.'
acknowledgement: The work was supported by the Simons Foundation (grant number 662960,
  to B.H.). Open access funding provided by Institute of Science and Technology (IST
  Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Bowen
  full_name: Yang, Bowen
  id: 71b6ff4b-15b2-11ec-abd3-aef6b028cf7e
  last_name: Yang
  orcid: 0000-0002-4843-6853
- first_name: Yi
  full_name: Zhuang, Yi
  id: 3677B57C-F248-11E8-B48F-1D18A9856A87
  last_name: Zhuang
- first_name: Gökhan
  full_name: Yalniz, Gökhan
  id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
  last_name: Yalniz
  orcid: 0000-0002-8490-9312
- first_name: Mukund
  full_name: Vasudevan, Mukund
  id: 3C5A959A-F248-11E8-B48F-1D18A9856A87
  last_name: Vasudevan
- first_name: Elena
  full_name: Marensi, Elena
  id: 0BE7553A-1004-11EA-B805-18983DDC885E
  last_name: Marensi
  orcid: 0000-0001-7173-4923
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
citation:
  ama: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. Discontinuous transition
    to shear flow turbulence. <i>Nature Physics</i>. 2026. doi:<a href="https://doi.org/10.1038/s41567-025-03166-3">10.1038/s41567-025-03166-3</a>
  apa: Yang, B., Zhuang, Y., Yalniz, G., Vasudevan, M., Marensi, E., &#38; Hof, B.
    (2026). Discontinuous transition to shear flow turbulence. <i>Nature Physics</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41567-025-03166-3">https://doi.org/10.1038/s41567-025-03166-3</a>
  chicago: Yang, Bowen, Yi Zhuang, Gökhan Yalniz, Mukund Vasudevan, Elena Marensi,
    and Björn Hof. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature
    Physics</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41567-025-03166-3">https://doi.org/10.1038/s41567-025-03166-3</a>.
  ieee: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, and B. Hof, “Discontinuous
    transition to shear flow turbulence,” <i>Nature Physics</i>. Springer Nature,
    2026.
  ista: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. 2026. Discontinuous
    transition to shear flow turbulence. Nature Physics.
  mla: Yang, Bowen, et al. “Discontinuous Transition to Shear Flow Turbulence.” <i>Nature
    Physics</i>, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41567-025-03166-3">10.1038/s41567-025-03166-3</a>.
  short: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, B. Hof, Nature Physics
    (2026).
corr_author: '1'
date_created: 2026-02-17T11:38:41Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:36:46Z
day: '17'
ddc:
- '532'
department:
- _id: GradSch
- _id: BjHo
doi: 10.1038/s41567-025-03166-3
external_id:
  arxiv:
  - '2311.11474'
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: Published Version
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
  grant_number: '662960'
  name: Revisiting the Turbulence Problem Using Statistical Mechanics
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discontinuous transition to shear flow turbulence
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21311'
abstract:
- lang: eng
  text: 'Air pollution is a critical public health issue worldwide, South America
    faces unique challenges due to rapid urban growth, industrial expansion, and recurrent
    biomass burning. Existing studies have largely focused on regional or national
    scales, overlooking detailed spatio-temporal dynamics in cities. This study provides
    a comprehensive assessment of air pollution spatio-temporal trends from 2013 to
    2023 in six major South American cities: Bogotá, Buenos Aires, Montevideo, Quito,
    Santiago de Chile, and São Paulo. We evaluated four key pollutants, NO2, O3, PM10,
    and PM2.5, using in situ monitoring networks complemented with reanalysis (boundary
    layer and pollution dynamics), and fire detections datasets (biomass burning).
    A key innovation is the use of a Lagrangian Tracker, which identifies persistent
    hotspots and transport pathways of pollutants, offering new insights into transboundary
    pollution. Results show that nearly all cities experienced reductions in particulate
    matter concentrations, while three of the six cities exhibited rising O3 levels,
    reflecting complex interactions between emissions, meteorology, and atmospheric
    chemistry. Santiago de Chile recorded the highest levels of NO2 and PM, strongly
    influenced by topography and biomass burning in JJA. Bogotá and Quito were notably
    impacted by regional fire emissions, whereas coastal cities such as Buenos Aires
    and Montevideo benefited from greater pollutant dispersion but still exceeded
    the World Health Organization guidelines. By integrating ground-based, satellite,
    and reanalysis data with advanced trajectory modeling, this research provides
    detailed spatio-temporal evaluations of air pollution in South America and highlights
    the urgent need for coordinated regional strategies to reduce health and economic
    burdens.'
acknowledgement: 'The author would like to thank Fundación Universitaria Los Libertadores
  (Project ID: ING-40-25) for supporting her in this work. And EALB, would like to
  thank Universidad Sergio Arboleda (Project ID: IN.BG.086.24.015) for supporting
  her in this work. Open access funding provided by Institute of Science and Technology
  (IST Austria). The first author was funded by the Fundacion Universitaria Los Libertadores
  (Project ID: ING-40-25). This project has received funding from the European Union’s
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  grant agreement No 101034413289 awarded to AC. EALB was supported by Universidad
  Sergio Arboleda (Project ID: IN.BG.086.24.015).'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuri
  full_name: González, Yuri
  last_name: González
- first_name: Nicolás
  full_name: Malagón, Nicolás
  last_name: Malagón
- first_name: Kevin
  full_name: Benavides, Kevin
  last_name: Benavides
- first_name: Luis Carlos
  full_name: Belalcázar, Luis Carlos
  last_name: Belalcázar
- first_name: Ellie Anne
  full_name: Lopez-Barrera, Ellie Anne
  last_name: Lopez-Barrera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
citation:
  ama: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. Spatio-temporal trends of air pollution in six South American cities.
    <i>Earth Systems and Environment</i>. 2026. doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>
  apa: González, Y., Malagón, N., Benavides, K., Belalcázar, L. C., Lopez-Barrera,
    E. A., &#38; Casallas Garcia, A. (2026). Spatio-temporal trends of air pollution
    in six South American cities. <i>Earth Systems and Environment</i>. Springer Nature.
    <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>
  chicago: González, Yuri, Nicolás Malagón, Kevin Benavides, Luis Carlos Belalcázar,
    Ellie Anne Lopez-Barrera, and Alejandro Casallas Garcia. “Spatio-Temporal Trends
    of Air Pollution in Six South American Cities.” <i>Earth Systems and Environment</i>.
    Springer Nature, 2026. <a href="https://doi.org/10.1007/s41748-026-01068-9">https://doi.org/10.1007/s41748-026-01068-9</a>.
  ieee: Y. González, N. Malagón, K. Benavides, L. C. Belalcázar, E. A. Lopez-Barrera,
    and A. Casallas Garcia, “Spatio-temporal trends of air pollution in six South
    American cities,” <i>Earth Systems and Environment</i>. Springer Nature, 2026.
  ista: González Y, Malagón N, Benavides K, Belalcázar LC, Lopez-Barrera EA, Casallas
    Garcia A. 2026. Spatio-temporal trends of air pollution in six South American
    cities. Earth Systems and Environment.
  mla: González, Yuri, et al. “Spatio-Temporal Trends of Air Pollution in Six South
    American Cities.” <i>Earth Systems and Environment</i>, Springer Nature, 2026,
    doi:<a href="https://doi.org/10.1007/s41748-026-01068-9">10.1007/s41748-026-01068-9</a>.
  short: Y. González, N. Malagón, K. Benavides, L.C. Belalcázar, E.A. Lopez-Barrera,
    A. Casallas Garcia, Earth Systems and Environment (2026).
corr_author: '1'
date_created: 2026-02-18T07:11:14Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:57:21Z
day: '17'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1007/s41748-026-01068-9
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1007/s41748-026-01068-9
month: '02'
oa: 1
oa_version: Published Version
publication: Earth Systems and Environment
publication_identifier:
  eissn:
  - 2509-9434
  issn:
  - 2509-9426
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatio-temporal trends of air pollution in six South American cities
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21340'
abstract:
- lang: eng
  text: Equilibrium quantum systems are often described by a gas of weakly interacting
    normal modes. Bringing such systems far from equilibrium, however, can drastically
    enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental
    question for quantum statistical mechanics and a practical question for engineering
    driven quantum devices. To tackle this question, we probe the non-equilibrium
    kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We
    introduce multimode spectroscopy to controllably study the departure from equilibrium,
    witnessing the evolution from pairwise coupling between plasma modes at weak driving
    to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode
    drives, we stimulate interactions between hundreds of modes, resulting in near-continuum
    internal dynamics. Imaging the resulting non-equilibrium plasmon populations,
    we then resolve the nonlocal redistribution of energy in the response to a weak
    perturbation—an explicit verification of the emergence of a strongly interacting,
    non-equilibrium liquid of plasmons.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: We thank V. Vitelli, M. Fruchart, and A. Burshstein for helpful input.
  We acknowledge technical support from the Nanofabrication Facility and the MIBA
  machine shop at IST Austria. This research was supported in part by grant NSF PHY-2309135
  to the Kavli Institute for Theoretical Physics (KITP), by the Austrian Science Fund
  (FWF) SFB F86, and by the NOMIS foundation.
article_number: eady7222
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Anton
  full_name: Bubis, Anton
  id: 1f6212b5-f795-11ec-9c0c-de4780302890
  last_name: Bubis
- first_name: Lucia
  full_name: Vigliotti, Lucia
  id: 539e1e1a-e604-11ee-a1df-f02b018e5c8c
  last_name: Vigliotti
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
citation:
  ama: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. Non-equilibrium plasmon liquid
    in a Josephson junction chain. <i>Science Advances</i>. 2026;12(7). doi:<a href="https://doi.org/10.1126/sciadv.ady7222">10.1126/sciadv.ady7222</a>
  apa: Bubis, A., Vigliotti, L., Serbyn, M., &#38; Higginbotham, A. P. (2026). Non-equilibrium
    plasmon liquid in a Josephson junction chain. <i>Science Advances</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.ady7222">https://doi.org/10.1126/sciadv.ady7222</a>
  chicago: Bubis, Anton, Lucia Vigliotti, Maksym Serbyn, and Andrew P Higginbotham.
    “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” <i>Science Advances</i>.
    American Association for the Advancement of Science, 2026. <a href="https://doi.org/10.1126/sciadv.ady7222">https://doi.org/10.1126/sciadv.ady7222</a>.
  ieee: A. Bubis, L. Vigliotti, M. Serbyn, and A. P. Higginbotham, “Non-equilibrium
    plasmon liquid in a Josephson junction chain,” <i>Science Advances</i>, vol. 12,
    no. 7. American Association for the Advancement of Science, 2026.
  ista: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. 2026. Non-equilibrium plasmon
    liquid in a Josephson junction chain. Science Advances. 12(7), eady7222.
  mla: Bubis, Anton, et al. “Non-Equilibrium Plasmon Liquid in a Josephson Junction
    Chain.” <i>Science Advances</i>, vol. 12, no. 7, eady7222, American Association
    for the Advancement of Science, 2026, doi:<a href="https://doi.org/10.1126/sciadv.ady7222">10.1126/sciadv.ady7222</a>.
  short: A. Bubis, L. Vigliotti, M. Serbyn, A.P. Higginbotham, Science Advances 12
    (2026).
corr_author: '1'
date_created: 2026-02-22T20:47:38Z
date_published: 2026-02-13T00:00:00Z
date_updated: 2026-02-24T07:25:34Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
- _id: AnHi
- _id: GeKa
doi: 10.1126/sciadv.ady7222
external_id:
  arxiv:
  - '2504.09721'
file:
- access_level: open_access
  checksum: 8402f322f8f0e858b1d9aac57e306e31
  content_type: application/pdf
  creator: dernst
  date_created: 2026-02-24T07:23:32Z
  date_updated: 2026-02-24T07:23:32Z
  file_id: '21353'
  file_name: 2026_ScienceAdv_Bubis.pdf
  file_size: 2775975
  relation: main_file
  success: 1
file_date_updated: 2026-02-24T07:23:32Z
has_accepted_license: '1'
intvolume: '        12'
issue: '7'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Non-equilibrium plasmon liquid in a Josephson junction chain
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '21341'
abstract:
- lang: eng
  text: We aim to characterise the mass-metallicity relation (MZR) and the 3D correlation
    between the stellar mass, metallicity, and star formation rate (SFR) known as
    the fundamental metallicity relation (FMR) for galaxies at 5 < z < 7. Using ∼800
    [O III] selected galaxies from deep NIRCam grism surveys, we present our stacked
    measurements of direct-Te metallicities, which we used to test recent strong-line
    metallicity calibrations. Our measured direct-Te metallicities (0.1–0.2 Z⊙ for
    M★ ≈ 5 × 107 − 9 M⊙, respectively) match recent JWST/NIRSpec-based results. However,
    there are significant inconsistencies between observations and hydrodynamical
    simulations. We observe a flatter MZR slope than the SPHINX20 and FLARES simulations,
    which cannot be attributed to selection effects. With simple models, we show that
    the effect of an [O III] flux-limited sample on the observed shape of the MZR
    is strongly dependent on the FMR. If the FMR is similar to the one in the local
    Universe, the intrinsic high-redshift MZR should be even flatter than is observed.
    In turn, a 3D relation where SFR correlates positively with metallicity at fixed
    mass would imply an intrinsically steeper MZR. Our measurements indicate that
    metallicity variations at fixed mass show little dependence on the SFR, suggesting
    a flat intrinsic MZR. This could indicate that the low-mass galaxies at these
    redshifts are out of equilibrium and that metal enrichment occurs rapidly in low-mass
    galaxies. However, being limited by our stacking analysis, we are yet to probe
    the scatter in the MZR and its dependence on SFR. Large carefully selected samples
    of galaxies with robust metallicity measurements can put tight constraints on
    the high-redshift FMR and help us to understand the interplay between gas flows,
    star formation, and feedback in early galaxies.
acknowledgement: 'We thank the anonymous referee for the insightful comments that
  helped improving this paper. This work is based on observations made with the NASA/ESA/CSA
  James Webb Space Telescope. The data were obtained from the Mikulski Archive for
  Space Telescopes at the Space Telescope Science Institute, which is operated by
  the Associations of Universities for Research in Astronomy, Inc., under NASA contract
  NAS 5-03127 for JWST. These observations were taken under programmes # 1243, # 1933
  and # 3516. Funded by the European Union (ERC, AGENTS, 101076224). Views and opinions
  expressed are however those of the author(s) only and do not necessarily reflect
  those of the European Union or the European Research Council. Neither the European
  Union nor the granting authority can be held responsible for them. GK acknowledges
  support from the Foundation MERAC. APV acknowledge support from the Sussex Astronomy
  Centre STFC Consolidated Grant (ST/X001040/1).'
article_number: A165
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gauri
  full_name: Kotiwale, Gauri
  id: 1438afc8-1ff6-11ee-9fa6-cd4a75d66875
  last_name: Kotiwale
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Daichi
  full_name: Kashino, Daichi
  last_name: Kashino
- first_name: Aswin P.
  full_name: Vijayan, Aswin P.
  last_name: Vijayan
- first_name: Alberto
  full_name: Torralba Torregrosa, Alberto
  id: 018f0249-0e87-11f0-b167-cbce08fbd541
  last_name: Torralba Torregrosa
  orcid: 0000-0001-5586-6950
- first_name: Claudia
  full_name: Di Cesare, Claudia
  id: 2d002343-372f-11ef-98ec-a164d20427cb
  last_name: Di Cesare
- first_name: Edoardo
  full_name: Iani, Edoardo
  id: 4053390a-6b68-11ef-9828-a3b8adef8d0a
  last_name: Iani
  orcid: 0000-0001-8386-3546
- first_name: Rongmon
  full_name: Bordoloi, Rongmon
  last_name: Bordoloi
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Michael V.
  full_name: Maseda, Michael V.
  last_name: Maseda
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Irene
  full_name: Shivaei, Irene
  last_name: Shivaei
- first_name: Kasper E.
  full_name: Heintz, Kasper E.
  last_name: Heintz
- first_name: A. Lola
  full_name: Danhaive, A. Lola
  last_name: Danhaive
- first_name: Sara
  full_name: Mascia, Sara
  id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29
  last_name: Mascia
- first_name: Ivan
  full_name: Kramarenko, Ivan
  id: 9a9394cb-3200-11ee-973b-f5ba2a8b16e4
  last_name: Kramarenko
  orcid: 0000-0001-5346-6048
- first_name: Benjamín
  full_name: Navarrete, Benjamín
  id: aa14a535-50c9-11ef-b52e-e0c373d10148
  last_name: Navarrete
- first_name: Ruari
  full_name: Mackenzie, Ruari
  last_name: Mackenzie
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: David
  full_name: Sobral, David
  last_name: Sobral
citation:
  ama: Kotiwale G, Matthee JJ, Kashino D, et al. Rapid, out-of-equilibrium metal enrichment
    indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy.
    <i>Astronomy &#38; Astrophysics</i>. 2026;706. doi:<a href="https://doi.org/10.1051/0004-6361/202556597">10.1051/0004-6361/202556597</a>
  apa: Kotiwale, G., Matthee, J. J., Kashino, D., Vijayan, A. P., Torralba Torregrosa,
    A., Di Cesare, C., … Sobral, D. (2026). Rapid, out-of-equilibrium metal enrichment
    indicated by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy.
    <i>Astronomy &#38; Astrophysics</i>. EDP Sciences. <a href="https://doi.org/10.1051/0004-6361/202556597">https://doi.org/10.1051/0004-6361/202556597</a>
  chicago: Kotiwale, Gauri, Jorryt J Matthee, Daichi Kashino, Aswin P. Vijayan, Alberto
    Torralba Torregrosa, Claudia Di Cesare, Edoardo Iani, et al. “Rapid, out-of-Equilibrium
    Metal Enrichment Indicated by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam
    Grism Spectroscopy.” <i>Astronomy &#38; Astrophysics</i>. EDP Sciences, 2026.
    <a href="https://doi.org/10.1051/0004-6361/202556597">https://doi.org/10.1051/0004-6361/202556597</a>.
  ieee: G. Kotiwale <i>et al.</i>, “Rapid, out-of-equilibrium metal enrichment indicated
    by a flat mass-metallicity relation at z ∼ 6 from NIRCam grism spectroscopy,”
    <i>Astronomy &#38; Astrophysics</i>, vol. 706. EDP Sciences, 2026.
  ista: Kotiwale G, Matthee JJ, Kashino D, Vijayan AP, Torralba Torregrosa A, Di Cesare
    C, Iani E, Bordoloi R, Leja J, Maseda MV, Tacchella S, Shivaei I, Heintz KE, Danhaive
    AL, Mascia S, Kramarenko I, Navarrete B, Mackenzie R, Naidu RP, Sobral D. 2026.
    Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity
    relation at z ∼ 6 from NIRCam grism spectroscopy. Astronomy &#38; Astrophysics.
    706, A165.
  mla: Kotiwale, Gauri, et al. “Rapid, out-of-Equilibrium Metal Enrichment Indicated
    by a Flat Mass-Metallicity Relation at z ∼ 6 from NIRCam Grism Spectroscopy.”
    <i>Astronomy &#38; Astrophysics</i>, vol. 706, A165, EDP Sciences, 2026, doi:<a
    href="https://doi.org/10.1051/0004-6361/202556597">10.1051/0004-6361/202556597</a>.
  short: G. Kotiwale, J.J. Matthee, D. Kashino, A.P. Vijayan, A. Torralba Torregrosa,
    C. Di Cesare, E. Iani, R. Bordoloi, J. Leja, M.V. Maseda, S. Tacchella, I. Shivaei,
    K.E. Heintz, A.L. Danhaive, S. Mascia, I. Kramarenko, B. Navarrete, R. Mackenzie,
    R.P. Naidu, D. Sobral, Astronomy &#38; Astrophysics 706 (2026).
corr_author: '1'
date_created: 2026-02-22T23:01:35Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-02-24T07:49:42Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
- _id: GradSch
doi: 10.1051/0004-6361/202556597
external_id:
  arxiv:
  - '2510.19959'
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  creator: dernst
  date_created: 2026-02-24T07:46:47Z
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intvolume: '       706'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: Astronomy & Astrophysics
publication_identifier:
  eissn:
  - 1432-0746
  issn:
  - 0004-6361
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rapid, out-of-equilibrium metal enrichment indicated by a flat mass-metallicity
  relation at z ∼ 6 from NIRCam grism spectroscopy
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 706
year: '2026'
...
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abstract:
- lang: eng
  text: "JWST has revealed a stunning population of bright galaxies at surprisingly
    early epochs, z > 10,\r\nwhere few such sources were expected. Here we present
    the most distant example of this class yet – MoM-z14, a luminous (MUV = −20.2)
    source in the COSMOS legacy field at zspec = 14.44+0.02−0.02 that expands the
    observational frontier to a mere 280 million years after the Big Bang. The redshift
    is confirmed with NIRSpec/prism spectroscopy through a sharp Lyman-α break and
    ≈ 3σ detections of five rest-UV emission lines. The number density of bright zspec
    ≈ 14 − 15 sources implied by our “Mirage or Miracle” survey spanning ≈ 350 arcmin2
    is > 100× larger (182+329 −105×) than pre-JWST consensus models. The high EWs
    of UV lines (≈15−35˚A) signal a rising star-formation history, with a ≈10× increase
    in the last 5 Myr (SFR5Myr/SFR50Myr = 9.9 +3.0 −5.8). The source is extremely
    compact (circularized re = 74+15\r\n−12 pc), and yet elongated (b/a = 0.25+0.11−0.06),
    suggesting an AGN is not the dominant source of UV light. The steep UV slope (β
    = −2.5 +0.2 −0.2) implies negligible dust attenuation\r\nand a young stellar population.
    The absence of a strong damping wing provides tentative evidence that the immediate
    surroundings of MoM-z14 may be partially ionized at a redshift where virtually
    every reionization model predicts a ≈ 100% neutral fraction. The nitrogen emission
    and highly supersolar [N/C]> 1 hint at an abundance pattern similar to local globular
    clusters that may have once hosted luminous supermassive stars. Since this abundance
    pattern is also common among the most ancient stars born in the Milky Way, we
    may be directly witnessing the formation of such stars in dense clusters, connecting
    galaxy evolution across the entire sweep of cosmic time. "
acknowledgement: "We thank the two anonymous referees for their insightful comments
  that have strengthened this work. “Mirage or Miracle” is but the latest link in
  a long chain of surveys that have built COSMOS into a premier extragalactic legacy
  field. We are thankful to all the teams who have contributed to this legacy, particularly
  those mentioned in §3 for leading recent JWST programs whose imaging\r\nwe have
  incorporated in our analysis. We are grateful to Vasily Belokurov for help in compiling
  the Milky Way reference sample featured in Fig 8. We thank Danielle Berg for sharing
  a highly complete, highly decimalized NUV vacuum line list. We are grateful to our
  program’s NIRSpec reviewer, Dan Coe, and program coordinator, Allison Vick, for
  valuable input on our MSA design. We acknowledge illuminating conversations with
  Risa Wechsler and Chao-Lin Kuo about early reionization. RPN thanks Neil Pappalardo
  and Jane Pappalardo for their generous support of the MIT Pappalardo Fellowships
  in Physics, and for their enthusiasm and encouragement for seeking galaxies at the
  highest redshifts. RPN acknowledges funding from JWST program GO5224. Support for
  this work was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A
  awarded by the Space Telescope Science Institute, which is operated by the Association
  of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.
  This work has received funding from the Swiss State Secretariat for Education, Research
  and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss
  National Science Foundation (SNSF) through project grant 200020 207349. Funded by
  the European Union (ERC, AGENTS, 101076224 and HEAVYMETAL, 101071865). Views and
  opinions expressed are however those of the author(s) only and do not necessarily
  reflect those of\r\nthe European Union or the European Research Council. Neither
  the European Union nor the granting authority can be held responsible for them.
  The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation
  under grant DNRF140. This work has also been supported by JSPS KAKENHI Grant Number
  23H00131. HA acknowledges support from CNES, focused on the JWST mission, and the
  Programme National Cosmology and Galaxies (PNCG)\r\nof CNRS/INSU with INP and IN2P3,
  co-funded by CEA and CNES. HA is supported by the French National Research Agency
  (ANR) under the project FIRSTGAL, grant number ANR-24-CE31-0838. SB is supported
  by the UK Research and Innovation (UKRI) Future Leaders Fellowship [grant number
  MR/V023381/1]. R.D. acknowledges support from the INAF GO 2022\r\ngrant “The birth
  of the giants: JWST sheds light on the build-up of quasars at cosmic dawn” and by
  the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006.
  Computations supporting this paper were run on MIT’s Engaging cluster. This publication
  made use of the NASA Astrophysical Data System for bibliographic information. Some
  of the data products presented herein were retrieved from the Dawn JWST Archive
  (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by
  the Danish National Research Foundation under grant DNRF140. Software used in developing
  this work includes: matplotlib (Hunter 2007), jupyter (Kluyver et al. 2016), IPython
  (P´erez & Granger 2007), numpy (Oliphant 2015), scipy (Virtanen et al. 2020), TOPCAT
  (Taylor 2005), and Astropy (Astropy Collaboration et al. 2013).This work is based
  on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data
  were obtained from the Mikulski Archive for Space\r\nTelescopes at the Space Telescope
  Science Institute, which is operated by the Association of Universities for Research
  in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations
  are associated with program # 5224."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Pascal A.
  full_name: Oesch, Pascal A.
  last_name: Oesch
- first_name: Gabriel
  full_name: Brammer, Gabriel
  last_name: Brammer
- first_name: Andrea
  full_name: Weibel, Andrea
  last_name: Weibel
- first_name: Yijia
  full_name: Li, Yijia
  last_name: Li
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: John
  full_name: Chisholm, John
  last_name: Chisholm
- first_name: Clara L.
  full_name: Pollock, Clara L.
  last_name: Pollock
- first_name: Kasper E.
  full_name: Heintz, Kasper E.
  last_name: Heintz
- first_name: Benjamin D.
  full_name: Johnson, Benjamin D.
  last_name: Johnson
- first_name: Xuejian
  full_name: Shen, Xuejian
  last_name: Shen
- first_name: Raphael E.
  full_name: Hviding, Raphael E.
  last_name: Hviding
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Arpita
  full_name: Ganguly, Arpita
  last_name: Ganguly
- first_name: Callum
  full_name: Witten, Callum
  last_name: Witten
- first_name: Hakim
  full_name: Atek, Hakim
  last_name: Atek
- first_name: Sirio
  full_name: Belli, Sirio
  last_name: Belli
- first_name: Sownak
  full_name: Bose, Sownak
  last_name: Bose
- first_name: Rychard
  full_name: Bouwens, Rychard
  last_name: Bouwens
- first_name: Pratika
  full_name: Dayal, Pratika
  last_name: Dayal
- first_name: Roberto
  full_name: Decarli, Roberto
  last_name: Decarli
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Yoshinobu
  full_name: Fudamoto, Yoshinobu
  last_name: Fudamoto
- first_name: Emma
  full_name: Giovinazzo, Emma
  last_name: Giovinazzo
- first_name: Jenny E.
  full_name: Greene, Jenny E.
  last_name: Greene
- first_name: Garth
  full_name: Illingworth, Garth
  last_name: Illingworth
- first_name: Akio K.
  full_name: Inoue, Akio K.
  last_name: Inoue
- first_name: Sarah G.
  full_name: Kane, Sarah G.
  last_name: Kane
- first_name: Ivo
  full_name: Labbe, Ivo
  last_name: Labbe
- first_name: Ecaterina
  full_name: Leonova, Ecaterina
  last_name: Leonova
- first_name: Rui
  full_name: Marques-Chaves, Rui
  last_name: Marques-Chaves
- first_name: Romain A.
  full_name: Meyer, Romain A.
  last_name: Meyer
- first_name: Erica J.
  full_name: Nelson, Erica J.
  last_name: Nelson
- first_name: Guido
  full_name: Roberts-Borsani, Guido
  last_name: Roberts-Borsani
- first_name: Daniel
  full_name: Schaerer, Daniel
  last_name: Schaerer
- first_name: Robert A.
  full_name: Simcoe, Robert A.
  last_name: Simcoe
- first_name: Mauro
  full_name: Stefanon, Mauro
  last_name: Stefanon
- first_name: Yuma
  full_name: Sugahara, Yuma
  last_name: Sugahara
- first_name: Sune
  full_name: Toft, Sune
  last_name: Toft
- first_name: Arjen
  full_name: Van Der Wel, Arjen
  last_name: Van Der Wel
- first_name: Pieter
  full_name: Van Dokkum, Pieter
  last_name: Van Dokkum
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Darach
  full_name: Watson, Darach
  last_name: Watson
- first_name: John R.
  full_name: Weaver, John R.
  last_name: Weaver
- first_name: Katherine E.
  full_name: Whitaker, Katherine E.
  last_name: Whitaker
citation:
  ama: 'Naidu RP, Oesch PA, Brammer G, et al. A cosmic miracle: A remarkably luminous
    galaxy at zspec = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>.
    2026;9. doi:<a href="https://doi.org/10.33232/001c.156033">10.33232/001c.156033</a>'
  apa: 'Naidu, R. P., Oesch, P. A., Brammer, G., Weibel, A., Li, Y., Matthee, J. J.,
    … Whitaker, K. E. (2026). A cosmic miracle: A remarkably luminous galaxy at zspec
    = 14.44 confirmed with JWST. <i>The Open Journal of Astrophysics</i>. Maynooth
    Academic Publishing. <a href="https://doi.org/10.33232/001c.156033">https://doi.org/10.33232/001c.156033</a>'
  chicago: 'Naidu, Rohan P., Pascal A. Oesch, Gabriel Brammer, Andrea Weibel, Yijia
    Li, Jorryt J Matthee, John Chisholm, et al. “A Cosmic Miracle: A Remarkably Luminous
    Galaxy at Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>.
    Maynooth Academic Publishing, 2026. <a href="https://doi.org/10.33232/001c.156033">https://doi.org/10.33232/001c.156033</a>.'
  ieee: 'R. P. Naidu <i>et al.</i>, “A cosmic miracle: A remarkably luminous galaxy
    at zspec = 14.44 confirmed with JWST,” <i>The Open Journal of Astrophysics</i>,
    vol. 9. Maynooth Academic Publishing, 2026.'
  ista: 'Naidu RP, Oesch PA, Brammer G, Weibel A, Li Y, Matthee JJ, Chisholm J, Pollock
    CL, Heintz KE, Johnson BD, Shen X, Hviding RE, Leja J, Tacchella S, Ganguly A,
    Witten C, Atek H, Belli S, Bose S, Bouwens R, Dayal P, Decarli R, De Graaff A,
    Fudamoto Y, Giovinazzo E, Greene JE, Illingworth G, Inoue AK, Kane SG, Labbe I,
    Leonova E, Marques-Chaves R, Meyer RA, Nelson EJ, Roberts-Borsani G, Schaerer
    D, Simcoe RA, Stefanon M, Sugahara Y, Toft S, Van Der Wel A, Van Dokkum P, Walter
    F, Watson D, Weaver JR, Whitaker KE. 2026. A cosmic miracle: A remarkably luminous
    galaxy at zspec = 14.44 confirmed with JWST. The Open Journal of Astrophysics.
    9.'
  mla: 'Naidu, Rohan P., et al. “A Cosmic Miracle: A Remarkably Luminous Galaxy at
    Zspec = 14.44 Confirmed with JWST.” <i>The Open Journal of Astrophysics</i>, vol.
    9, Maynooth Academic Publishing, 2026, doi:<a href="https://doi.org/10.33232/001c.156033">10.33232/001c.156033</a>.'
  short: R.P. Naidu, P.A. Oesch, G. Brammer, A. Weibel, Y. Li, J.J. Matthee, J. Chisholm,
    C.L. Pollock, K.E. Heintz, B.D. Johnson, X. Shen, R.E. Hviding, J. Leja, S. Tacchella,
    A. Ganguly, C. Witten, H. Atek, S. Belli, S. Bose, R. Bouwens, P. Dayal, R. Decarli,
    A. De Graaff, Y. Fudamoto, E. Giovinazzo, J.E. Greene, G. Illingworth, A.K. Inoue,
    S.G. Kane, I. Labbe, E. Leonova, R. Marques-Chaves, R.A. Meyer, E.J. Nelson, G.
    Roberts-Borsani, D. Schaerer, R.A. Simcoe, M. Stefanon, Y. Sugahara, S. Toft,
    A. Van Der Wel, P. Van Dokkum, F. Walter, D. Watson, J.R. Weaver, K.E. Whitaker,
    The Open Journal of Astrophysics 9 (2026).
date_created: 2026-02-22T23:01:35Z
date_published: 2026-01-30T00:00:00Z
date_updated: 2026-02-24T07:37:17Z
day: '30'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.33232/001c.156033
external_id:
  arxiv:
  - '2505.11263'
has_accepted_license: '1'
intvolume: '         9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https:/​/​doi.org/​10.33232/​001c.156033
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: The Open Journal of Astrophysics
publication_identifier:
  eissn:
  - 2565-6120
publication_status: published
publisher: Maynooth Academic Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A cosmic miracle: A remarkably luminous galaxy at zspec = 14.44 confirmed
  with JWST'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2026'
...
