---
_id: '326'
abstract:
- lang: eng
  text: Three-dimensional (3D) super-resolution microscopy technique structured illumination
    microscopy (SIM) imaging of dendritic spines along the dendrite has not been previously
    performed in fixed tissues, mainly due to deterioration of the stripe pattern
    of the excitation laser induced by light scattering and optical aberrations. To
    address this issue and solve these optical problems, we applied a novel clearing
    reagent, LUCID, to fixed brains. In SIM imaging, the penetration depth and the
    spatial resolution were improved in LUCID-treated slices, and 160-nm spatial resolution
    was obtained in a large portion of the imaging volume on a single apical dendrite.
    Furthermore, in a morphological analysis of spine heads of layer V pyramidal neurons
    (L5PNs) in the medial prefrontal cortex (mPFC) of chronic dexamethasone (Dex)-treated
    mice, SIM imaging revealed an altered distribution of spine forms that could not
    be detected by high-NA confocal imaging. Thus, super-resolution SIM imaging represents
    a promising high-throughput method for revealing spine morphologies in single
    dendrites.
acknowledged_ssus:
- _id: EM-Fac
article_processing_charge: No
author:
- first_name: Kazuaki
  full_name: Sawada, Kazuaki
  last_name: Sawada
- first_name: Ryosuke
  full_name: Kawakami, Ryosuke
  last_name: Kawakami
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Tomomi
  full_name: Nemoto, Tomomi
  last_name: Nemoto
citation:
  ama: Sawada K, Kawakami R, Shigemoto R, Nemoto T. Super resolution structural analysis
    of dendritic spines using three-dimensional structured illumination microscopy
    in cleared mouse brain slices. <i>European Journal of Neuroscience</i>. 2018;47(9):1033-1042.
    doi:<a href="https://doi.org/10.1111/ejn.13901">10.1111/ejn.13901</a>
  apa: Sawada, K., Kawakami, R., Shigemoto, R., &#38; Nemoto, T. (2018). Super resolution
    structural analysis of dendritic spines using three-dimensional structured illumination
    microscopy in cleared mouse brain slices. <i>European Journal of Neuroscience</i>.
    Wiley. <a href="https://doi.org/10.1111/ejn.13901">https://doi.org/10.1111/ejn.13901</a>
  chicago: Sawada, Kazuaki, Ryosuke Kawakami, Ryuichi Shigemoto, and Tomomi Nemoto.
    “Super Resolution Structural Analysis of Dendritic Spines Using Three-Dimensional
    Structured Illumination Microscopy in Cleared Mouse Brain Slices.” <i>European
    Journal of Neuroscience</i>. Wiley, 2018. <a href="https://doi.org/10.1111/ejn.13901">https://doi.org/10.1111/ejn.13901</a>.
  ieee: K. Sawada, R. Kawakami, R. Shigemoto, and T. Nemoto, “Super resolution structural
    analysis of dendritic spines using three-dimensional structured illumination microscopy
    in cleared mouse brain slices,” <i>European Journal of Neuroscience</i>, vol.
    47, no. 9. Wiley, pp. 1033–1042, 2018.
  ista: Sawada K, Kawakami R, Shigemoto R, Nemoto T. 2018. Super resolution structural
    analysis of dendritic spines using three-dimensional structured illumination microscopy
    in cleared mouse brain slices. European Journal of Neuroscience. 47(9), 1033–1042.
  mla: Sawada, Kazuaki, et al. “Super Resolution Structural Analysis of Dendritic
    Spines Using Three-Dimensional Structured Illumination Microscopy in Cleared Mouse
    Brain Slices.” <i>European Journal of Neuroscience</i>, vol. 47, no. 9, Wiley,
    2018, pp. 1033–42, doi:<a href="https://doi.org/10.1111/ejn.13901">10.1111/ejn.13901</a>.
  short: K. Sawada, R. Kawakami, R. Shigemoto, T. Nemoto, European Journal of Neuroscience
    47 (2018) 1033–1042.
date_created: 2018-12-11T11:45:50Z
date_published: 2018-03-07T00:00:00Z
date_updated: 2023-09-19T09:58:40Z
day: '07'
ddc:
- '570'
department:
- _id: RySh
doi: 10.1111/ejn.13901
external_id:
  isi:
  - '000431496400001'
file:
- access_level: open_access
  checksum: 98e901d8229e44aa8f3b51d248dedd09
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:16:50Z
  date_updated: 2020-07-14T12:46:06Z
  file_id: '5721'
  file_name: 2018_EJN_Sawada.pdf
  file_size: 4850261
  relation: main_file
file_date_updated: 2020-07-14T12:46:06Z
has_accepted_license: '1'
intvolume: '        47'
isi: 1
issue: '9'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1033 - 1042
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley
publist_id: '7539'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Super resolution structural analysis of dendritic spines using three-dimensional
  structured illumination microscopy in cleared mouse brain slices
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 47
year: '2018'
...
---
_id: '327'
abstract:
- lang: eng
  text: Many-body quantum systems typically display fast dynamics and ballistic spreading
    of information. Here we address the open problem of how slow the dynamics can
    be after a generic breaking of integrability by local interactions. We develop
    a method based on degenerate perturbation theory that reveals slow dynamical regimes
    and delocalization processes in general translation invariant models, along with
    accurate estimates of their delocalization time scales. Our results shed light
    on the fundamental questions of the robustness of quantum integrable systems and
    the possibility of many-body localization without disorder. As an example, we
    construct a large class of one-dimensional lattice models where, despite the absence
    of asymptotic localization, the transient dynamics is exceptionally slow, i.e.,
    the dynamics is indistinguishable from that of many-body localized systems for
    the system sizes and time scales accessible in experiments and numerical simulations.
acknowledgement: 'We thank F. Huveneers for useful discussions. Z.P. and A.M. acknowledge
  support by EPSRC Grant No. EP/P009409/1 and and the Royal Society Research Grant
  No. RG160635. Statement of compliance with EPSRC policy framework on research data:
  This publication is theoretical work that does not require supporting research data.
  D.A. acknowledges support by the Swiss National Science Foundation. M.Z., M.M. and
  T.P. acknowledge Grants J1-7279 (M.Z.) and N1-0025 (M.M. and T.P.) of Slovenian
  Research Agency, and Advanced Grant of European Research Council, Grant No. 694544
  - OMNES (T.P.).'
article_number: '104307'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alexios
  full_name: Michailidis, Alexios
  id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
  last_name: Michailidis
  orcid: 0000-0002-8443-1064
- first_name: Marko
  full_name: Žnidarič, Marko
  last_name: Žnidarič
- first_name: Mariya
  full_name: Medvedyeva, Mariya
  last_name: Medvedyeva
- first_name: Dmitry
  full_name: Abanin, Dmitry
  last_name: Abanin
- first_name: Tomaž
  full_name: Prosen, Tomaž
  last_name: Prosen
- first_name: Zlatko
  full_name: Papić, Zlatko
  last_name: Papić
citation:
  ama: Michailidis A, Žnidarič M, Medvedyeva M, Abanin D, Prosen T, Papić Z. Slow
    dynamics in translation-invariant quantum lattice models. <i>Physical Review B</i>.
    2018;97(10). doi:<a href="https://doi.org/10.1103/PhysRevB.97.104307">10.1103/PhysRevB.97.104307</a>
  apa: Michailidis, A., Žnidarič, M., Medvedyeva, M., Abanin, D., Prosen, T., &#38;
    Papić, Z. (2018). Slow dynamics in translation-invariant quantum lattice models.
    <i>Physical Review B</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevB.97.104307">https://doi.org/10.1103/PhysRevB.97.104307</a>
  chicago: Michailidis, Alexios, Marko Žnidarič, Mariya Medvedyeva, Dmitry Abanin,
    Tomaž Prosen, and Zlatko Papić. “Slow Dynamics in Translation-Invariant Quantum
    Lattice Models.” <i>Physical Review B</i>. American Physical Society, 2018. <a
    href="https://doi.org/10.1103/PhysRevB.97.104307">https://doi.org/10.1103/PhysRevB.97.104307</a>.
  ieee: A. Michailidis, M. Žnidarič, M. Medvedyeva, D. Abanin, T. Prosen, and Z. Papić,
    “Slow dynamics in translation-invariant quantum lattice models,” <i>Physical Review
    B</i>, vol. 97, no. 10. American Physical Society, 2018.
  ista: Michailidis A, Žnidarič M, Medvedyeva M, Abanin D, Prosen T, Papić Z. 2018.
    Slow dynamics in translation-invariant quantum lattice models. Physical Review
    B. 97(10), 104307.
  mla: Michailidis, Alexios, et al. “Slow Dynamics in Translation-Invariant Quantum
    Lattice Models.” <i>Physical Review B</i>, vol. 97, no. 10, 104307, American Physical
    Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevB.97.104307">10.1103/PhysRevB.97.104307</a>.
  short: A. Michailidis, M. Žnidarič, M. Medvedyeva, D. Abanin, T. Prosen, Z. Papić,
    Physical Review B 97 (2018).
date_created: 2018-12-11T11:45:50Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2025-06-04T07:50:22Z
day: '19'
department:
- _id: MaSe
doi: 10.1103/PhysRevB.97.104307
external_id:
  arxiv:
  - '1706.05026'
  isi:
  - '000427798800005'
intvolume: '        97'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1706.05026
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_status: published
publisher: American Physical Society
publist_id: '7538'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Slow dynamics in translation-invariant quantum lattice models
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 97
year: '2018'
...
---
_id: '328'
abstract:
- lang: eng
  text: The drag of turbulent flows can be drastically decreased by adding small amounts
    of high molecular weight polymers. While drag reduction initially increases with
    polymer concentration, it eventually saturates to what is known as the maximum
    drag reduction (MDR) asymptote; this asymptote is generally attributed to the
    dynamics being reduced to a marginal yet persistent state of subdued turbulent
    motion. Contrary to this accepted view, we show that, for an appropriate choice
    of parameters, polymers can reduce the drag beyond the suggested asymptotic limit,
    eliminating turbulence and giving way to laminar flow. At higher polymer concentrations,
    however, the laminar state becomes unstable, resulting in a fluctuating flow with
    the characteristic drag of the MDR asymptote. Our findings indicate that the asymptotic
    state is hence dynamically disconnected from ordinary turbulence. © 2018 American
    Physical Society.
acknowledged_ssus:
- _id: SSU
acknowledgement: The authors thank Philipp Maier and the IST Austria workshop for
  their dedicated technical support.
article_number: '124501'
article_processing_charge: No
arxiv: 1
author:
- first_name: George H
  full_name: Choueiri, George H
  id: 448BD5BC-F248-11E8-B48F-1D18A9856A87
  last_name: Choueiri
- first_name: Jose M
  full_name: Lopez Alonso, Jose M
  id: 40770848-F248-11E8-B48F-1D18A9856A87
  last_name: Lopez Alonso
  orcid: 0000-0002-0384-2022
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
citation:
  ama: Choueiri GH, Lopez Alonso JM, Hof B. Exceeding the asymptotic limit of polymer
    drag reduction. <i>Physical Review Letters</i>. 2018;120(12). doi:<a href="https://doi.org/10.1103/PhysRevLett.120.124501">10.1103/PhysRevLett.120.124501</a>
  apa: Choueiri, G. H., Lopez Alonso, J. M., &#38; Hof, B. (2018). Exceeding the asymptotic
    limit of polymer drag reduction. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevLett.120.124501">https://doi.org/10.1103/PhysRevLett.120.124501</a>
  chicago: Choueiri, George H, Jose M Lopez Alonso, and Björn Hof. “Exceeding the
    Asymptotic Limit of Polymer Drag Reduction.” <i>Physical Review Letters</i>. American
    Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevLett.120.124501">https://doi.org/10.1103/PhysRevLett.120.124501</a>.
  ieee: G. H. Choueiri, J. M. Lopez Alonso, and B. Hof, “Exceeding the asymptotic
    limit of polymer drag reduction,” <i>Physical Review Letters</i>, vol. 120, no.
    12. American Physical Society, 2018.
  ista: Choueiri GH, Lopez Alonso JM, Hof B. 2018. Exceeding the asymptotic limit
    of polymer drag reduction. Physical Review Letters. 120(12), 124501.
  mla: Choueiri, George H., et al. “Exceeding the Asymptotic Limit of Polymer Drag
    Reduction.” <i>Physical Review Letters</i>, vol. 120, no. 12, 124501, American
    Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevLett.120.124501">10.1103/PhysRevLett.120.124501</a>.
  short: G.H. Choueiri, J.M. Lopez Alonso, B. Hof, Physical Review Letters 120 (2018).
corr_author: '1'
date_created: 2018-12-11T11:45:51Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2025-06-04T07:52:00Z
day: '19'
department:
- _id: BjHo
doi: 10.1103/PhysRevLett.120.124501
ec_funded: 1
external_id:
  arxiv:
  - '1703.06271'
  isi:
  - '000427804000005'
intvolume: '       120'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1703.06271
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '306589'
  name: Decoding the complexity of turbulence at its origin
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '7537'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exceeding the asymptotic limit of polymer drag reduction
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 120
year: '2018'
...
---
_id: '33'
abstract:
- lang: eng
  text: Secondary contact is the reestablishment of gene flow between sister populations
    that have diverged. For instance, at the end of the Quaternary glaciations in
    Europe, secondary contact occurred during the northward expansion of the populations
    which had found refugia in the southern peninsulas. With the advent of multi-locus
    markers, secondary contact can be investigated using various molecular signatures
    including gradients of allele frequency, admixture clines, and local increase
    of genetic differentiation. We use coalescent simulations to investigate if molecular
    data provide enough information to distinguish between secondary contact following
    range expansion and an alternative evolutionary scenario consisting of a barrier
    to gene flow in an isolation-by-distance model. We find that an excess of linkage
    disequilibrium and of genetic diversity at the suture zone is a unique signature
    of secondary contact. We also find that the directionality index ψ, which was
    proposed to study range expansion, is informative to distinguish between the two
    hypotheses. However, although evidence for secondary contact is usually conveyed
    by statistics related to admixture coefficients, we find that they can be confounded
    by isolation-by-distance. We recommend to account for the spatial repartition
    of individuals when investigating secondary contact in order to better reflect
    the complex spatio-temporal evolution of populations and species.
acknowledgement: 'Johanna Bertl was supported by the Vienna Graduate School of Population
  Genetics (Austrian Science Fund (FWF): W1225-B20) and worked on this project while
  employed at the Department of Statistics and Operations Research, University of
  Vienna, Austria. This article was developed in the framework of the Grenoble Alpes
  Data Institute, which is supported by the French National Research Agency under
  the “Investissments d’avenir” program (ANR-15-IDEX-02).'
article_number: e5325
article_processing_charge: No
author:
- first_name: Johanna
  full_name: Bertl, Johanna
  last_name: Bertl
- first_name: Harald
  full_name: Ringbauer, Harald
  id: 417FCFF4-F248-11E8-B48F-1D18A9856A87
  last_name: Ringbauer
  orcid: 0000-0002-4884-9682
- first_name: Michaël
  full_name: Blum, Michaël
  last_name: Blum
citation:
  ama: Bertl J, Ringbauer H, Blum M. Can secondary contact following range expansion
    be distinguished from barriers to gene flow? <i>PeerJ</i>. 2018;2018(10). doi:<a
    href="https://doi.org/10.7717/peerj.5325">10.7717/peerj.5325</a>
  apa: Bertl, J., Ringbauer, H., &#38; Blum, M. (2018). Can secondary contact following
    range expansion be distinguished from barriers to gene flow? <i>PeerJ</i>. PeerJ.
    <a href="https://doi.org/10.7717/peerj.5325">https://doi.org/10.7717/peerj.5325</a>
  chicago: Bertl, Johanna, Harald Ringbauer, and Michaël Blum. “Can Secondary Contact
    Following Range Expansion Be Distinguished from Barriers to Gene Flow?” <i>PeerJ</i>.
    PeerJ, 2018. <a href="https://doi.org/10.7717/peerj.5325">https://doi.org/10.7717/peerj.5325</a>.
  ieee: J. Bertl, H. Ringbauer, and M. Blum, “Can secondary contact following range
    expansion be distinguished from barriers to gene flow?,” <i>PeerJ</i>, vol. 2018,
    no. 10. PeerJ, 2018.
  ista: Bertl J, Ringbauer H, Blum M. 2018. Can secondary contact following range
    expansion be distinguished from barriers to gene flow? PeerJ. 2018(10), e5325.
  mla: Bertl, Johanna, et al. “Can Secondary Contact Following Range Expansion Be
    Distinguished from Barriers to Gene Flow?” <i>PeerJ</i>, vol. 2018, no. 10, e5325,
    PeerJ, 2018, doi:<a href="https://doi.org/10.7717/peerj.5325">10.7717/peerj.5325</a>.
  short: J. Bertl, H. Ringbauer, M. Blum, PeerJ 2018 (2018).
date_created: 2018-12-11T11:44:16Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2023-10-17T12:24:43Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.7717/peerj.5325
external_id:
  isi:
  - '000447204400001'
  pmid:
  - '30294507'
file:
- access_level: open_access
  checksum: 3334886c4b39678db4c4b74299ca14ba
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T10:46:06Z
  date_updated: 2020-07-14T12:46:06Z
  file_id: '5692'
  file_name: 2018_PeerJ_Bertl.pdf
  file_size: 1328344
  relation: main_file
file_date_updated: 2020-07-14T12:46:06Z
has_accepted_license: '1'
intvolume: '      2018'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: PeerJ
publication_status: published
publisher: PeerJ
publist_id: '8022'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Can secondary contact following range expansion be distinguished from barriers
  to gene flow?
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2018
year: '2018'
...
---
_id: '3300'
abstract:
- lang: eng
  text: "This book first explores the origins of this idea, grounded in theoretical
    work on temporal logic and automata. The editors and authors are among the world's
    leading researchers in this domain, and they contributed 32 chapters representing
    a thorough view of the development and application of the technique. Topics covered
    include binary decision diagrams, symbolic model checking, satisfiability modulo
    theories, partial-order reduction, abstraction, interpolation, concurrency, security
    protocols, games, probabilistic model checking, and process algebra, and chapters
    on the transfer of theory to industrial practice, property specification languages
    for hardware, and verification of real-time systems and hybrid systems.\r\n\r\nThe
    book will be valuable for researchers and graduate students engaged with the development
    of formal methods and verification tools."
article_processing_charge: No
author:
- first_name: Edmund M.
  full_name: Clarke, Edmund M.
  last_name: Clarke
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Helmut
  full_name: Veith, Helmut
  last_name: Veith
- first_name: Roderick
  full_name: Bloem, Roderick
  last_name: Bloem
citation:
  ama: 'Clarke EM, Henzinger TA, Veith H, Bloem R. <i>Handbook of Model Checking</i>.
    1st ed. Cham: Springer Nature; 2018. doi:<a href="https://doi.org/10.1007/978-3-319-10575-8">10.1007/978-3-319-10575-8</a>'
  apa: 'Clarke, E. M., Henzinger, T. A., Veith, H., &#38; Bloem, R. (2018). <i>Handbook
    of Model Checking</i> (1st ed.). Cham: Springer Nature. <a href="https://doi.org/10.1007/978-3-319-10575-8">https://doi.org/10.1007/978-3-319-10575-8</a>'
  chicago: 'Clarke, Edmund M., Thomas A Henzinger, Helmut Veith, and Roderick Bloem.
    <i>Handbook of Model Checking</i>. 1st ed. Cham: Springer Nature, 2018. <a href="https://doi.org/10.1007/978-3-319-10575-8">https://doi.org/10.1007/978-3-319-10575-8</a>.'
  ieee: 'E. M. Clarke, T. A. Henzinger, H. Veith, and R. Bloem, <i>Handbook of Model
    Checking</i>, 1st ed. Cham: Springer Nature, 2018.'
  ista: 'Clarke EM, Henzinger TA, Veith H, Bloem R. 2018. Handbook of Model Checking
    1st ed., Cham: Springer Nature, XLVIII, 1212p.'
  mla: Clarke, Edmund M., et al. <i>Handbook of Model Checking</i>. 1st ed., Springer
    Nature, 2018, doi:<a href="https://doi.org/10.1007/978-3-319-10575-8">10.1007/978-3-319-10575-8</a>.
  short: E.M. Clarke, T.A. Henzinger, H. Veith, R. Bloem, Handbook of Model Checking,
    1st ed., Springer Nature, Cham, 2018.
date_created: 2018-12-11T12:02:32Z
date_published: 2018-06-08T00:00:00Z
date_updated: 2021-12-21T10:49:36Z
day: '08'
department:
- _id: ToHe
doi: 10.1007/978-3-319-10575-8
edition: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: XLVIII, 1212
place: Cham
publication_identifier:
  eisbn:
  - 978-3-319-10575-8
  isbn:
  - 978-3-319-10574-1
publication_status: published
publisher: Springer Nature
publist_id: '3340'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Handbook of Model Checking
type: book
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2018'
...
---
_id: '34'
abstract:
- lang: eng
  text: Partially observable Markov decision processes (POMDPs) are widely used in
    probabilistic planning problems in which an agent interacts with an environment
    using noisy and imprecise sensors. We study a setting in which the sensors are
    only partially defined and the goal is to synthesize “weakest” additional sensors,
    such that in the resulting POMDP, there is a small-memory policy for the agent
    that almost-surely (with probability 1) satisfies a reachability objective. We
    show that the problem is NP-complete, and present a symbolic algorithm by encoding
    the problem into SAT instances. We illustrate trade-offs between the amount of
    memory of the policy and the number of additional sensors on a simple example.
    We have implemented our approach and consider three classical POMDP examples from
    the literature, and show that in all the examples the number of sensors can be
    significantly decreased (as compared to the existing solutions in the literature)
    without increasing the complexity of the policies.
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Chemlík, Martin
  last_name: Chemlík
- first_name: Ufuk
  full_name: Topcu, Ufuk
  last_name: Topcu
citation:
  ama: 'Chatterjee K, Chemlík M, Topcu U. Sensor synthesis for POMDPs with reachability
    objectives. In: <i>28th International Conference on Automated Planning and Scheduling</i>.
    Vol 2018. AAAI Press; 2018:47-55. doi:<a href="https://doi.org/10.1609/icaps.v28i1.13875">10.1609/icaps.v28i1.13875</a>'
  apa: 'Chatterjee, K., Chemlík, M., &#38; Topcu, U. (2018). Sensor synthesis for
    POMDPs with reachability objectives. In <i>28th International Conference on Automated
    Planning and Scheduling</i> (Vol. 2018, pp. 47–55). Delft, Netherlands: AAAI Press.
    <a href="https://doi.org/10.1609/icaps.v28i1.13875">https://doi.org/10.1609/icaps.v28i1.13875</a>'
  chicago: Chatterjee, Krishnendu, Martin Chemlík, and Ufuk Topcu. “Sensor Synthesis
    for POMDPs with Reachability Objectives.” In <i>28th International Conference
    on Automated Planning and Scheduling</i>, 2018:47–55. AAAI Press, 2018. <a href="https://doi.org/10.1609/icaps.v28i1.13875">https://doi.org/10.1609/icaps.v28i1.13875</a>.
  ieee: K. Chatterjee, M. Chemlík, and U. Topcu, “Sensor synthesis for POMDPs with
    reachability objectives,” in <i>28th International Conference on Automated Planning
    and Scheduling</i>, Delft, Netherlands, 2018, vol. 2018, pp. 47–55.
  ista: 'Chatterjee K, Chemlík M, Topcu U. 2018. Sensor synthesis for POMDPs with
    reachability objectives. 28th International Conference on Automated Planning and
    Scheduling. ICAPS: International Conference on Automated Planning and Scheduling
    vol. 2018, 47–55.'
  mla: Chatterjee, Krishnendu, et al. “Sensor Synthesis for POMDPs with Reachability
    Objectives.” <i>28th International Conference on Automated Planning and Scheduling</i>,
    vol. 2018, AAAI Press, 2018, pp. 47–55, doi:<a href="https://doi.org/10.1609/icaps.v28i1.13875">10.1609/icaps.v28i1.13875</a>.
  short: K. Chatterjee, M. Chemlík, U. Topcu, in:, 28th International Conference on
    Automated Planning and Scheduling, AAAI Press, 2018, pp. 47–55.
conference:
  end_date: 2018-06-29
  location: Delft, Netherlands
  name: 'ICAPS: International Conference on Automated Planning and Scheduling'
  start_date: 2018-06-24
date_created: 2018-12-11T11:44:16Z
date_published: 2018-06-01T00:00:00Z
date_updated: 2025-04-15T07:23:29Z
day: '01'
department:
- _id: KrCh
doi: 10.1609/icaps.v28i1.13875
ec_funded: 1
external_id:
  arxiv:
  - '1710.00675'
  isi:
  - '000492986200006'
intvolume: '      2018'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1710.00675
month: '06'
oa: 1
oa_version: Preprint
page: 47 - 55
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
publication: 28th International Conference on Automated Planning and Scheduling
publication_status: published
publisher: AAAI Press
publist_id: '8021'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sensor synthesis for POMDPs with reachability objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2018
year: '2018'
...
---
_id: '134'
abstract:
- lang: eng
  text: "The current state of the art in real-time two-dimensional water wave simulation
    requires developers to choose between efficient Fourier-based methods, which lack
    interactions with moving obstacles, and finite-difference or finite element methods,
    which handle environmental interactions but are significantly more expensive.
    This paper attempts to bridge this long-standing gap between complexity and performance,
    by proposing a new wave simulation method that can faithfully simulate wave interactions
    with moving obstacles in real time while simultaneously preserving minute details
    and accommodating very large simulation domains.\r\n\r\nPrevious methods for simulating
    2D water waves directly compute the change in height of the water surface, a strategy
    which imposes limitations based on the CFL condition (fast moving waves require
    small time steps) and Nyquist's limit (small wave details require closely-spaced
    simulation variables). This paper proposes a novel wavelet transformation that
    discretizes the liquid motion in terms of amplitude-like functions that vary over
    space, frequency, and direction, effectively generalizing Fourier-based methods
    to handle local interactions. Because these new variables change much more slowly
    over space than the original water height function, our change of variables drastically
    reduces the limitations of the CFL condition and Nyquist limit, allowing us to
    simulate highly detailed water waves at very large visual resolutions. Our discretization
    is amenable to fast summation and easy to parallelize. We also present basic extensions
    like pre-computed wave paths and two-way solid fluid coupling. Finally, we argue
    that our discretization provides a convenient set of variables for artistic manipulation,
    which we illustrate with a novel wave-painting interface."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- SIGGRAPH
article_number: '94'
article_processing_charge: No
author:
- first_name: Stefan
  full_name: Jeschke, Stefan
  id: 44D6411A-F248-11E8-B48F-1D18A9856A87
  last_name: Jeschke
- first_name: Tomas
  full_name: Skrivan, Tomas
  id: 486A5A46-F248-11E8-B48F-1D18A9856A87
  last_name: Skrivan
- first_name: Matthias
  full_name: Mueller Fischer, Matthias
  last_name: Mueller Fischer
- first_name: Nuttapong
  full_name: Chentanez, Nuttapong
  last_name: Chentanez
- first_name: Miles
  full_name: Macklin, Miles
  last_name: Macklin
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
citation:
  ama: Jeschke S, Skrivan T, Mueller Fischer M, Chentanez N, Macklin M, Wojtan C.
    Water surface wavelets. <i>ACM Transactions on Graphics</i>. 2018;37(4). doi:<a
    href="https://doi.org/10.1145/3197517.3201336">10.1145/3197517.3201336</a>
  apa: Jeschke, S., Skrivan, T., Mueller Fischer, M., Chentanez, N., Macklin, M.,
    &#38; Wojtan, C. (2018). Water surface wavelets. <i>ACM Transactions on Graphics</i>.
    ACM. <a href="https://doi.org/10.1145/3197517.3201336">https://doi.org/10.1145/3197517.3201336</a>
  chicago: Jeschke, Stefan, Tomas Skrivan, Matthias Mueller Fischer, Nuttapong Chentanez,
    Miles Macklin, and Chris Wojtan. “Water Surface Wavelets.” <i>ACM Transactions
    on Graphics</i>. ACM, 2018. <a href="https://doi.org/10.1145/3197517.3201336">https://doi.org/10.1145/3197517.3201336</a>.
  ieee: S. Jeschke, T. Skrivan, M. Mueller Fischer, N. Chentanez, M. Macklin, and
    C. Wojtan, “Water surface wavelets,” <i>ACM Transactions on Graphics</i>, vol.
    37, no. 4. ACM, 2018.
  ista: Jeschke S, Skrivan T, Mueller Fischer M, Chentanez N, Macklin M, Wojtan C.
    2018. Water surface wavelets. ACM Transactions on Graphics. 37(4), 94.
  mla: Jeschke, Stefan, et al. “Water Surface Wavelets.” <i>ACM Transactions on Graphics</i>,
    vol. 37, no. 4, 94, ACM, 2018, doi:<a href="https://doi.org/10.1145/3197517.3201336">10.1145/3197517.3201336</a>.
  short: S. Jeschke, T. Skrivan, M. Mueller Fischer, N. Chentanez, M. Macklin, C.
    Wojtan, ACM Transactions on Graphics 37 (2018).
date_created: 2018-12-11T11:44:48Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2024-10-22T09:58:20Z
day: '30'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1145/3197517.3201336
ec_funded: 1
external_id:
  isi:
  - '000448185000055'
file:
- access_level: open_access
  checksum: db75ebabe2ec432bf41389e614d6ef62
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:59:23Z
  date_updated: 2020-07-14T12:44:45Z
  file_id: '5744'
  file_name: 2018_ACM_Jeschke.pdf
  file_size: 22185016
  relation: main_file
file_date_updated: 2020-07-14T12:44:45Z
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '638176'
  name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
    Scales'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '7789'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/new-water-simulation-captures-small-details-even-in-large-scenes/
scopus_import: '1'
status: public
title: Water surface wavelets
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2018'
...
---
_id: '135'
abstract:
- lang: eng
  text: The Fluid Implicit Particle method (FLIP) reduces numerical dissipation by
    combining particles with grids. To improve performance, the subsequent narrow
    band FLIP method (NB‐FLIP) uses a FLIP‐based fluid simulation only near the liquid
    surface and a traditional grid‐based fluid simulation away from the surface. This
    spatially‐limited FLIP simulation significantly reduces the number of particles
    and alleviates a computational bottleneck. In this paper, we extend the NB‐FLIP
    idea even further, by allowing a simulation to transition between a FLIP‐like
    fluid simulation and a grid‐based simulation in arbitrary locations, not just
    near the surface. This approach leads to even more savings in memory and computation,
    because we can concentrate the particles only in areas where they are needed.
    More importantly, this new method allows us to seamlessly transition to smooth
    implicit surface geometry wherever the particle‐based simulation is unnecessary.
    Consequently, our method leads to a practical algorithm for avoiding the noisy
    surface artifacts associated with particle‐based liquid simulations, while simultaneously
    maintaining the benefits of a FLIP simulation in regions of dynamic motion.
alternative_title:
- Eurographics
article_processing_charge: No
article_type: original
author:
- first_name: Takahiro
  full_name: Sato, Takahiro
  last_name: Sato
- first_name: Christopher J
  full_name: Wojtan, Christopher J
  id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
  last_name: Wojtan
  orcid: 0000-0001-6646-5546
- first_name: Nils
  full_name: Thuerey, Nils
  last_name: Thuerey
- first_name: Takeo
  full_name: Igarashi, Takeo
  last_name: Igarashi
- first_name: Ryoichi
  full_name: Ando, Ryoichi
  last_name: Ando
citation:
  ama: Sato T, Wojtan C, Thuerey N, Igarashi T, Ando R. Extended narrow band FLIP
    for liquid simulations. <i>Computer Graphics Forum</i>. 2018;37(2):169-177. doi:<a
    href="https://doi.org/10.1111/cgf.13351">10.1111/cgf.13351</a>
  apa: Sato, T., Wojtan, C., Thuerey, N., Igarashi, T., &#38; Ando, R. (2018). Extended
    narrow band FLIP for liquid simulations. <i>Computer Graphics Forum</i>. Wiley.
    <a href="https://doi.org/10.1111/cgf.13351">https://doi.org/10.1111/cgf.13351</a>
  chicago: Sato, Takahiro, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi
    Ando. “Extended Narrow Band FLIP for Liquid Simulations.” <i>Computer Graphics
    Forum</i>. Wiley, 2018. <a href="https://doi.org/10.1111/cgf.13351">https://doi.org/10.1111/cgf.13351</a>.
  ieee: T. Sato, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Extended narrow
    band FLIP for liquid simulations,” <i>Computer Graphics Forum</i>, vol. 37, no.
    2. Wiley, pp. 169–177, 2018.
  ista: Sato T, Wojtan C, Thuerey N, Igarashi T, Ando R. 2018. Extended narrow band
    FLIP for liquid simulations. Computer Graphics Forum. 37(2), 169–177.
  mla: Sato, Takahiro, et al. “Extended Narrow Band FLIP for Liquid Simulations.”
    <i>Computer Graphics Forum</i>, vol. 37, no. 2, Wiley, 2018, pp. 169–77, doi:<a
    href="https://doi.org/10.1111/cgf.13351">10.1111/cgf.13351</a>.
  short: T. Sato, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, Computer Graphics Forum
    37 (2018) 169–177.
date_created: 2018-12-11T11:44:49Z
date_published: 2018-05-22T00:00:00Z
date_updated: 2024-10-22T09:58:20Z
day: '22'
ddc:
- '006'
department:
- _id: ChWo
doi: 10.1111/cgf.13351
ec_funded: 1
external_id:
  isi:
  - '000434085600016'
file:
- access_level: open_access
  checksum: 8edb90da8a72395eb5d970580e0925b6
  content_type: application/pdf
  creator: wojtan
  date_created: 2020-10-08T08:38:23Z
  date_updated: 2020-10-08T08:38:23Z
  file_id: '8627'
  file_name: exnbflip.pdf
  file_size: 54309947
  relation: main_file
  success: 1
file_date_updated: 2020-10-08T08:38:23Z
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 169 - 177
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '638176'
  name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
    Scales'
publication: Computer Graphics Forum
publication_identifier:
  issn:
  - 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extended narrow band FLIP for liquid simulations
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 37
year: '2018'
...
---
_id: '136'
abstract:
- lang: eng
  text: Recent studies suggest that unstable, nonchaotic solutions of the Navier-Stokes
    equation may provide deep insights into fluid turbulence. In this article, we
    present a combined experimental and numerical study exploring the dynamical role
    of unstable equilibrium solutions and their invariant manifolds in a weakly turbulent,
    electromagnetically driven, shallow fluid layer. Identifying instants when turbulent
    evolution slows down, we compute 31 unstable equilibria of a realistic two-dimensional
    model of the flow. We establish the dynamical relevance of these unstable equilibria
    by showing that they are closely visited by the turbulent flow. We also establish
    the dynamical relevance of unstable manifolds by verifying that they are shadowed
    by turbulent trajectories departing from the neighborhoods of unstable equilibria
    over large distances in state space.
article_processing_charge: No
arxiv: 1
author:
- first_name: Balachandra
  full_name: Suri, Balachandra
  id: 47A5E706-F248-11E8-B48F-1D18A9856A87
  last_name: Suri
- first_name: Jeffrey
  full_name: Tithof, Jeffrey
  last_name: Tithof
- first_name: Roman
  full_name: Grigoriev, Roman
  last_name: Grigoriev
- first_name: Michael
  full_name: Schatz, Michael
  last_name: Schatz
citation:
  ama: Suri B, Tithof J, Grigoriev R, Schatz M. Unstable equilibria and invariant
    manifolds in quasi-two-dimensional Kolmogorov-like flow. <i>Physical Review E</i>.
    2018;98(2). doi:<a href="https://doi.org/10.1103/PhysRevE.98.023105">10.1103/PhysRevE.98.023105</a>
  apa: Suri, B., Tithof, J., Grigoriev, R., &#38; Schatz, M. (2018). Unstable equilibria
    and invariant manifolds in quasi-two-dimensional Kolmogorov-like flow. <i>Physical
    Review E</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevE.98.023105">https://doi.org/10.1103/PhysRevE.98.023105</a>
  chicago: Suri, Balachandra, Jeffrey Tithof, Roman Grigoriev, and Michael Schatz.
    “Unstable Equilibria and Invariant Manifolds in Quasi-Two-Dimensional Kolmogorov-like
    Flow.” <i>Physical Review E</i>. American Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevE.98.023105">https://doi.org/10.1103/PhysRevE.98.023105</a>.
  ieee: B. Suri, J. Tithof, R. Grigoriev, and M. Schatz, “Unstable equilibria and
    invariant manifolds in quasi-two-dimensional Kolmogorov-like flow,” <i>Physical
    Review E</i>, vol. 98, no. 2. American Physical Society, 2018.
  ista: Suri B, Tithof J, Grigoriev R, Schatz M. 2018. Unstable equilibria and invariant
    manifolds in quasi-two-dimensional Kolmogorov-like flow. Physical Review E. 98(2).
  mla: Suri, Balachandra, et al. “Unstable Equilibria and Invariant Manifolds in Quasi-Two-Dimensional
    Kolmogorov-like Flow.” <i>Physical Review E</i>, vol. 98, no. 2, American Physical
    Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevE.98.023105">10.1103/PhysRevE.98.023105</a>.
  short: B. Suri, J. Tithof, R. Grigoriev, M. Schatz, Physical Review E 98 (2018).
date_created: 2018-12-11T11:44:49Z
date_published: 2018-08-13T00:00:00Z
date_updated: 2023-10-10T13:29:10Z
day: '13'
department:
- _id: BjHo
doi: 10.1103/PhysRevE.98.023105
external_id:
  arxiv:
  - '1808.02088'
  isi:
  - '000441466800010'
intvolume: '        98'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1808.02088
month: '08'
oa: 1
oa_version: Submitted Version
publication: Physical Review E
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unstable equilibria and invariant manifolds in quasi-two-dimensional Kolmogorov-like
  flow
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 98
year: '2018'
...
---
_id: '137'
abstract:
- lang: eng
  text: Fluorescent sensors are an essential part of the experimental toolbox of the
    life sciences, where they are used ubiquitously to visualize intra- and extracellular
    signaling. In the brain, optical neurotransmitter sensors can shed light on temporal
    and spatial aspects of signal transmission by directly observing, for instance,
    neurotransmitter release and spread. Here we report the development and application
    of the first optical sensor for the amino acid glycine, which is both an inhibitory
    neurotransmitter and a co-agonist of the N-methyl-d-aspartate receptors (NMDARs)
    involved in synaptic plasticity. Computational design of a glycine-specific binding
    protein allowed us to produce the optical glycine FRET sensor (GlyFS), which can
    be used with single and two-photon excitation fluorescence microscopy. We took
    advantage of this newly developed sensor to test predictions about the uneven
    spatial distribution of glycine in extracellular space and to demonstrate that
    extracellular glycine levels are controlled by plasticity-inducing stimuli.
article_processing_charge: No
article_type: original
author:
- first_name: William
  full_name: Zhang, William
  last_name: Zhang
- first_name: Michel
  full_name: Herde, Michel
  last_name: Herde
- first_name: Joshua
  full_name: Mitchell, Joshua
  last_name: Mitchell
- first_name: Jason
  full_name: Whitfield, Jason
  last_name: Whitfield
- first_name: Andreas
  full_name: Wulff, Andreas
  last_name: Wulff
- first_name: Vanessa
  full_name: Vongsouthi, Vanessa
  last_name: Vongsouthi
- first_name: Inmaculada
  full_name: Sanchez Romero, Inmaculada
  id: 3D9C5D30-F248-11E8-B48F-1D18A9856A87
  last_name: Sanchez Romero
- first_name: Polina
  full_name: Gulakova, Polina
  last_name: Gulakova
- first_name: Daniel
  full_name: Minge, Daniel
  last_name: Minge
- first_name: Björn
  full_name: Breithausen, Björn
  last_name: Breithausen
- first_name: Susanne
  full_name: Schoch, Susanne
  last_name: Schoch
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Colin
  full_name: Jackson, Colin
  last_name: Jackson
- first_name: Christian
  full_name: Henneberger, Christian
  last_name: Henneberger
citation:
  ama: Zhang W, Herde M, Mitchell J, et al. Monitoring hippocampal glycine with the
    computationally designed optical sensor GlyFS. <i>Nature Chemical Biology</i>.
    2018;14(9):861-869. doi:<a href="https://doi.org/10.1038/s41589-018-0108-2">10.1038/s41589-018-0108-2</a>
  apa: Zhang, W., Herde, M., Mitchell, J., Whitfield, J., Wulff, A., Vongsouthi, V.,
    … Henneberger, C. (2018). Monitoring hippocampal glycine with the computationally
    designed optical sensor GlyFS. <i>Nature Chemical Biology</i>. Nature Publishing
    Group. <a href="https://doi.org/10.1038/s41589-018-0108-2">https://doi.org/10.1038/s41589-018-0108-2</a>
  chicago: Zhang, William, Michel Herde, Joshua Mitchell, Jason Whitfield, Andreas
    Wulff, Vanessa Vongsouthi, Inmaculada Sanchez-Romero, et al. “Monitoring Hippocampal
    Glycine with the Computationally Designed Optical Sensor GlyFS.” <i>Nature Chemical
    Biology</i>. Nature Publishing Group, 2018. <a href="https://doi.org/10.1038/s41589-018-0108-2">https://doi.org/10.1038/s41589-018-0108-2</a>.
  ieee: W. Zhang <i>et al.</i>, “Monitoring hippocampal glycine with the computationally
    designed optical sensor GlyFS,” <i>Nature Chemical Biology</i>, vol. 14, no. 9.
    Nature Publishing Group, pp. 861–869, 2018.
  ista: Zhang W, Herde M, Mitchell J, Whitfield J, Wulff A, Vongsouthi V, Sanchez-Romero
    I, Gulakova P, Minge D, Breithausen B, Schoch S, Janovjak HL, Jackson C, Henneberger
    C. 2018. Monitoring hippocampal glycine with the computationally designed optical
    sensor GlyFS. Nature Chemical Biology. 14(9), 861–869.
  mla: Zhang, William, et al. “Monitoring Hippocampal Glycine with the Computationally
    Designed Optical Sensor GlyFS.” <i>Nature Chemical Biology</i>, vol. 14, no. 9,
    Nature Publishing Group, 2018, pp. 861–69, doi:<a href="https://doi.org/10.1038/s41589-018-0108-2">10.1038/s41589-018-0108-2</a>.
  short: W. Zhang, M. Herde, J. Mitchell, J. Whitfield, A. Wulff, V. Vongsouthi, I.
    Sanchez-Romero, P. Gulakova, D. Minge, B. Breithausen, S. Schoch, H.L. Janovjak,
    C. Jackson, C. Henneberger, Nature Chemical Biology 14 (2018) 861–869.
date_created: 2018-12-11T11:44:49Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2025-04-15T06:43:11Z
day: '30'
department:
- _id: HaJa
doi: 10.1038/s41589-018-0108-2
external_id:
  isi:
  - '000442174500013'
  pmid:
  - '30061718 '
intvolume: '        14'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30061718
month: '07'
oa: 1
oa_version: Submitted Version
page: 861 - 869
pmid: 1
project:
- _id: 255BFFFA-B435-11E9-9278-68D0E5697425
  grant_number: RGY0084/2012
  name: In situ real-time imaging of neurotransmitter signaling using designer optical
    sensors
publication: Nature Chemical Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '7786'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Monitoring hippocampal glycine with the computationally designed optical sensor
  GlyFS
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 14
year: '2018'
...
---
_id: '139'
abstract:
- lang: eng
  text: 'Genome-scale diversity data are increasingly available in a variety of biological
    systems, and can be used to reconstruct the past evolutionary history of species
    divergence. However, extracting the full demographic information from these data
    is not trivial, and requires inferential methods that account for the diversity
    of coalescent histories throughout the genome. Here, we evaluate the potential
    and limitations of one such approach. We reexamine a well-known system of mussel
    sister species, using the joint site frequency spectrum (jSFS) of synonymousmutations
    computed either fromexome capture or RNA-seq, in an Approximate Bayesian Computation
    (ABC) framework. We first assess the best sampling strategy (number of: individuals,
    loci, and bins in the jSFS), and show that model selection is robust to variation
    in the number of individuals and loci. In contrast, different binning choices
    when summarizing the jSFS, strongly affect the results: including classes of low
    and high frequency shared polymorphisms can more effectively reveal recent migration
    events. We then take advantage of the flexibility of ABC to compare more realistic
    models of speciation, including variation in migration rates through time (i.e.,
    periodic connectivity) and across genes (i.e., genome-wide heterogeneity in migration
    rates). We show that these models were consistently selected as the most probable,
    suggesting that mussels have experienced a complex history of gene flow during
    divergence and that the species boundary is semi-permeable. Our work provides
    a comprehensive evaluation of ABC demographic inference in mussels based on the
    coding jSFS, and supplies guidelines for employing different sequencing techniques
    and sampling strategies. We emphasize, perhaps surprisingly, that inferences are
    less limited by the volume of data, than by the way in which they are analyzed.'
article_number: '30083438'
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Camille
  full_name: Roux, Camille
  last_name: Roux
- first_name: Pierre
  full_name: Gagnaire, Pierre
  last_name: Gagnaire
- first_name: Jonathan
  full_name: Romiguier, Jonathan
  last_name: Romiguier
- first_name: Nicolas
  full_name: Faivre, Nicolas
  last_name: Faivre
- first_name: John
  full_name: Welch, John
  last_name: Welch
- first_name: Nicolas
  full_name: Bierne, Nicolas
  last_name: Bierne
citation:
  ama: 'Fraisse C, Roux C, Gagnaire P, et al. The divergence history of European blue
    mussel species reconstructed from Approximate Bayesian Computation: The effects
    of sequencing techniques and sampling strategies. <i>PeerJ</i>. 2018;2018(7).
    doi:<a href="https://doi.org/10.7717/peerj.5198">10.7717/peerj.5198</a>'
  apa: 'Fraisse, C., Roux, C., Gagnaire, P., Romiguier, J., Faivre, N., Welch, J.,
    &#38; Bierne, N. (2018). The divergence history of European blue mussel species
    reconstructed from Approximate Bayesian Computation: The effects of sequencing
    techniques and sampling strategies. <i>PeerJ</i>. PeerJ. <a href="https://doi.org/10.7717/peerj.5198">https://doi.org/10.7717/peerj.5198</a>'
  chicago: 'Fraisse, Christelle, Camille Roux, Pierre Gagnaire, Jonathan Romiguier,
    Nicolas Faivre, John Welch, and Nicolas Bierne. “The Divergence History of European
    Blue Mussel Species Reconstructed from Approximate Bayesian Computation: The Effects
    of Sequencing Techniques and Sampling Strategies.” <i>PeerJ</i>. PeerJ, 2018.
    <a href="https://doi.org/10.7717/peerj.5198">https://doi.org/10.7717/peerj.5198</a>.'
  ieee: 'C. Fraisse <i>et al.</i>, “The divergence history of European blue mussel
    species reconstructed from Approximate Bayesian Computation: The effects of sequencing
    techniques and sampling strategies,” <i>PeerJ</i>, vol. 2018, no. 7. PeerJ, 2018.'
  ista: 'Fraisse C, Roux C, Gagnaire P, Romiguier J, Faivre N, Welch J, Bierne N.
    2018. The divergence history of European blue mussel species reconstructed from
    Approximate Bayesian Computation: The effects of sequencing techniques and sampling
    strategies. PeerJ. 2018(7), 30083438.'
  mla: 'Fraisse, Christelle, et al. “The Divergence History of European Blue Mussel
    Species Reconstructed from Approximate Bayesian Computation: The Effects of Sequencing
    Techniques and Sampling Strategies.” <i>PeerJ</i>, vol. 2018, no. 7, 30083438,
    PeerJ, 2018, doi:<a href="https://doi.org/10.7717/peerj.5198">10.7717/peerj.5198</a>.'
  short: C. Fraisse, C. Roux, P. Gagnaire, J. Romiguier, N. Faivre, J. Welch, N. Bierne,
    PeerJ 2018 (2018).
date_created: 2018-12-11T11:44:50Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2023-10-17T12:25:28Z
day: '30'
ddc:
- '576'
department:
- _id: BeVi
- _id: NiBa
doi: 10.7717/peerj.5198
external_id:
  isi:
  - '000440484800002'
file:
- access_level: open_access
  checksum: 7d55ae22598a1c70759cd671600cff53
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T09:42:11Z
  date_updated: 2020-07-14T12:44:48Z
  file_id: '5739'
  file_name: 2018_PeerJ_Fraisse.pdf
  file_size: 1480792
  relation: main_file
file_date_updated: 2020-07-14T12:44:48Z
has_accepted_license: '1'
intvolume: '      2018'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: PeerJ
publication_status: published
publisher: PeerJ
publist_id: '7784'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The divergence history of European blue mussel species reconstructed from
  Approximate Bayesian Computation: The effects of sequencing techniques and sampling
  strategies'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2018
year: '2018'
...
---
_id: '14'
abstract:
- lang: eng
  text: The intercellular transport of auxin is driven by PIN-formed (PIN) auxin efflux
    carriers. PINs are localized at the plasma membrane (PM) and on constitutively
    recycling endomembrane vesicles. Therefore, PINs can mediate auxin transport either
    by direct translocation across the PM or by pumping auxin into secretory vesicles
    (SVs), leading to its secretory release upon fusion with the PM. Which of these
    two mechanisms dominates is a matter of debate. Here, we addressed the issue with
    a mathematical modeling approach. We demonstrate that the efficiency of secretory
    transport depends on SV size, half-life of PINs on the PM, pH, exocytosis frequency
    and PIN density. 3D structured illumination microscopy (SIM) was used to determine
    PIN density on the PM. Combining this data with published values of the other
    parameters, we show that the transport activity of PINs in SVs would have to be
    at least 1000× greater than on the PM in order to produce a comparable macroscopic
    auxin transport. If both transport mechanisms operated simultaneously and PINs
    were equally active on SVs and PM, the contribution of secretion to the total
    auxin flux would be negligible. In conclusion, while secretory vesicle-mediated
    transport of auxin is an intriguing and theoretically possible model, it is unlikely
    to be a major mechanism of auxin transport inplanta.
acknowledgement: 'European Research Council (ERC): 742985 to Jiri Friml; M.A. was
  supported by the Austrian Science Fund (FWF) (M2379-B28); AJ was supported by the
  Austria Science Fund (FWF): I03630 to Jiri Friml.'
article_processing_charge: No
article_type: original
author:
- first_name: Sander
  full_name: Hille, Sander
  last_name: Hille
- first_name: Maria
  full_name: Akhmanova, Maria
  id: 3425EC26-F248-11E8-B48F-1D18A9856A87
  last_name: Akhmanova
  orcid: 0000-0003-1522-3162
- first_name: Matous
  full_name: Glanc, Matous
  id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
  last_name: Glanc
  orcid: 0000-0003-0619-7783
- first_name: Alexander J
  full_name: Johnson, Alexander J
  id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
  last_name: Johnson
  orcid: 0000-0002-2739-8843
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: 'Hille S, Akhmanova M, Glanc M, Johnson AJ, Friml J. Relative contribution
    of PIN-containing secretory vesicles and plasma membrane PINs to the directed
    auxin transport: Theoretical estimation. <i>International Journal of Molecular
    Sciences</i>. 2018;19(11). doi:<a href="https://doi.org/10.3390/ijms19113566">10.3390/ijms19113566</a>'
  apa: 'Hille, S., Akhmanova, M., Glanc, M., Johnson, A. J., &#38; Friml, J. (2018).
    Relative contribution of PIN-containing secretory vesicles and plasma membrane
    PINs to the directed auxin transport: Theoretical estimation. <i>International
    Journal of Molecular Sciences</i>. MDPI. <a href="https://doi.org/10.3390/ijms19113566">https://doi.org/10.3390/ijms19113566</a>'
  chicago: 'Hille, Sander, Maria Akhmanova, Matous Glanc, Alexander J Johnson, and
    Jiří Friml. “Relative Contribution of PIN-Containing Secretory Vesicles and Plasma
    Membrane PINs to the Directed Auxin Transport: Theoretical Estimation.” <i>International
    Journal of Molecular Sciences</i>. MDPI, 2018. <a href="https://doi.org/10.3390/ijms19113566">https://doi.org/10.3390/ijms19113566</a>.'
  ieee: 'S. Hille, M. Akhmanova, M. Glanc, A. J. Johnson, and J. Friml, “Relative
    contribution of PIN-containing secretory vesicles and plasma membrane PINs to
    the directed auxin transport: Theoretical estimation,” <i>International Journal
    of Molecular Sciences</i>, vol. 19, no. 11. MDPI, 2018.'
  ista: 'Hille S, Akhmanova M, Glanc M, Johnson AJ, Friml J. 2018. Relative contribution
    of PIN-containing secretory vesicles and plasma membrane PINs to the directed
    auxin transport: Theoretical estimation. International Journal of Molecular Sciences.
    19(11).'
  mla: 'Hille, Sander, et al. “Relative Contribution of PIN-Containing Secretory Vesicles
    and Plasma Membrane PINs to the Directed Auxin Transport: Theoretical Estimation.”
    <i>International Journal of Molecular Sciences</i>, vol. 19, no. 11, MDPI, 2018,
    doi:<a href="https://doi.org/10.3390/ijms19113566">10.3390/ijms19113566</a>.'
  short: S. Hille, M. Akhmanova, M. Glanc, A.J. Johnson, J. Friml, International Journal
    of Molecular Sciences 19 (2018).
date_created: 2018-12-11T11:44:09Z
date_published: 2018-11-12T00:00:00Z
date_updated: 2025-04-14T07:45:00Z
day: '12'
ddc:
- '580'
department:
- _id: DaSi
- _id: JiFr
doi: 10.3390/ijms19113566
ec_funded: 1
external_id:
  isi:
  - '000451528500282'
file:
- access_level: open_access
  checksum: e4b59c2599b0ca26ebf5b8434bcde94a
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T16:04:11Z
  date_updated: 2020-07-14T12:44:50Z
  file_id: '5719'
  file_name: 2018_IJMS_Hille.pdf
  file_size: 2200593
  relation: main_file
file_date_updated: 2020-07-14T12:44:50Z
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03630
  name: Molecular mechanisms of endocytic cargo recognition in plants
publication: International Journal of Molecular Sciences
publication_identifier:
  eissn:
  - 1422-0067
publication_status: published
publisher: MDPI
publist_id: '8042'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Relative contribution of PIN-containing secretory vesicles and plasma membrane
  PINs to the directed auxin transport: Theoretical estimation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
_id: '14198'
abstract:
- lang: eng
  text: "High-dimensional time series are common in many domains. Since human\r\ncognition
    is not optimized to work well in high-dimensional spaces, these areas\r\ncould
    benefit from interpretable low-dimensional representations. However, most\r\nrepresentation
    learning algorithms for time series data are difficult to\r\ninterpret. This is
    due to non-intuitive mappings from data features to salient\r\nproperties of the
    representation and non-smoothness over time. To address this\r\nproblem, we propose
    a new representation learning framework building on ideas\r\nfrom interpretable
    discrete dimensionality reduction and deep generative\r\nmodeling. This framework
    allows us to learn discrete representations of time\r\nseries, which give rise
    to smooth and interpretable embeddings with superior\r\nclustering performance.
    We introduce a new way to overcome the\r\nnon-differentiability in discrete representation
    learning and present a\r\ngradient-based version of the traditional self-organizing
    map algorithm that is\r\nmore performant than the original. Furthermore, to allow
    for a probabilistic\r\ninterpretation of our method, we integrate a Markov model
    in the representation\r\nspace. This model uncovers the temporal transition structure,
    improves\r\nclustering performance even further and provides additional explanatory\r\ninsights
    as well as a natural representation of uncertainty. We evaluate our\r\nmodel in
    terms of clustering performance and interpretability on static\r\n(Fashion-)MNIST
    data, a time series of linearly interpolated (Fashion-)MNIST\r\nimages, a chaotic
    Lorenz attractor system with two macro states, as well as on\r\na challenging
    real world medical time series application on the eICU data set.\r\nOur learned
    representations compare favorably with competitor methods and\r\nfacilitate downstream
    tasks on the real world data."
article_processing_charge: No
arxiv: 1
author:
- first_name: Vincent
  full_name: Fortuin, Vincent
  last_name: Fortuin
- first_name: Matthias
  full_name: Hüser, Matthias
  last_name: Hüser
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Heiko
  full_name: Strathmann, Heiko
  last_name: Strathmann
- first_name: Gunnar
  full_name: Rätsch, Gunnar
  last_name: Rätsch
citation:
  ama: 'Fortuin V, Hüser M, Locatello F, Strathmann H, Rätsch G. SOM-VAE: Interpretable
    discrete representation learning on time series. In: <i>International Conference
    on Learning Representations</i>. ; 2018.'
  apa: 'Fortuin, V., Hüser, M., Locatello, F., Strathmann, H., &#38; Rätsch, G. (2018).
    SOM-VAE: Interpretable discrete representation learning on time series. In <i>International
    Conference on Learning Representations</i>. New Orleans, LA, United States.'
  chicago: 'Fortuin, Vincent, Matthias Hüser, Francesco Locatello, Heiko Strathmann,
    and Gunnar Rätsch. “SOM-VAE: Interpretable Discrete Representation Learning on
    Time Series.” In <i>International Conference on Learning Representations</i>,
    2018.'
  ieee: 'V. Fortuin, M. Hüser, F. Locatello, H. Strathmann, and G. Rätsch, “SOM-VAE:
    Interpretable discrete representation learning on time series,” in <i>International
    Conference on Learning Representations</i>, New Orleans, LA, United States, 2018.'
  ista: 'Fortuin V, Hüser M, Locatello F, Strathmann H, Rätsch G. 2018. SOM-VAE: Interpretable
    discrete representation learning on time series. International Conference on Learning
    Representations. ICLR: International Conference on Learning Representations.'
  mla: 'Fortuin, Vincent, et al. “SOM-VAE: Interpretable Discrete Representation Learning
    on Time Series.” <i>International Conference on Learning Representations</i>,
    2018.'
  short: V. Fortuin, M. Hüser, F. Locatello, H. Strathmann, G. Rätsch, in:, International
    Conference on Learning Representations, 2018.
conference:
  end_date: 2019-05-09
  location: New Orleans, LA, United States
  name: 'ICLR: International Conference on Learning Representations'
  start_date: 2019-05-06
date_created: 2023-08-22T14:12:48Z
date_published: 2018-06-06T00:00:00Z
date_updated: 2023-09-13T06:35:12Z
day: '06'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1806.02199'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1806.02199
month: '06'
oa: 1
oa_version: Preprint
publication: International Conference on Learning Representations
publication_status: published
quality_controlled: '1'
status: public
title: 'SOM-VAE: Interpretable discrete representation learning on time series'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '142'
abstract:
- lang: eng
  text: We address the problem of analyzing the reachable set of a polynomial nonlinear
    continuous system by over-approximating the flowpipe of its dynamics. The common
    approach to tackle this problem is to perform a numerical integration over a given
    time horizon based on Taylor expansion and interval arithmetic. However, this
    method results to be very conservative when there is a large difference in speed
    between trajectories as time progresses. In this paper, we propose to use combinations
    of barrier functions, which we call piecewise barrier tube (PBT), to over-approximate
    flowpipe. The basic idea of PBT is that for each segment of a flowpipe, a coarse
    box which is big enough to contain the segment is constructed using sampled simulation
    and then in the box we compute by linear programming a set of barrier functions
    (called barrier tube or BT for short) which work together to form a tube surrounding
    the flowpipe. The benefit of using PBT is that (1) BT is independent of time and
    hence can avoid being stretched and deformed by time; and (2) a small number of
    BTs can form a tight over-approximation for the flowpipe, which means that the
    computation required to decide whether the BTs intersect the unsafe set can be
    reduced significantly. We implemented a prototype called PBTS in C++. Experiments
    on some benchmark systems show that our approach is effective.
acknowledgement: 'Austrian Science Fund FWF: S11402-N23, S11405-N23, Z211-N32'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Hui
  full_name: Kong, Hui
  id: 3BDE25AA-F248-11E8-B48F-1D18A9856A87
  last_name: Kong
  orcid: 0000-0002-3066-6941
- first_name: Ezio
  full_name: Bartocci, Ezio
  last_name: Bartocci
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Kong H, Bartocci E, Henzinger TA. Reachable set over-approximation for nonlinear
    systems using piecewise barrier tubes. In: Vol 10981. Springer; 2018:449-467.
    doi:<a href="https://doi.org/10.1007/978-3-319-96145-3_24">10.1007/978-3-319-96145-3_24</a>'
  apa: 'Kong, H., Bartocci, E., &#38; Henzinger, T. A. (2018). Reachable set over-approximation
    for nonlinear systems using piecewise barrier tubes (Vol. 10981, pp. 449–467).
    Presented at the CAV: Computer Aided Verification, Oxford, United Kingdom: Springer.
    <a href="https://doi.org/10.1007/978-3-319-96145-3_24">https://doi.org/10.1007/978-3-319-96145-3_24</a>'
  chicago: Kong, Hui, Ezio Bartocci, and Thomas A Henzinger. “Reachable Set Over-Approximation
    for Nonlinear Systems Using Piecewise Barrier Tubes,” 10981:449–67. Springer,
    2018. <a href="https://doi.org/10.1007/978-3-319-96145-3_24">https://doi.org/10.1007/978-3-319-96145-3_24</a>.
  ieee: 'H. Kong, E. Bartocci, and T. A. Henzinger, “Reachable set over-approximation
    for nonlinear systems using piecewise barrier tubes,” presented at the CAV: Computer
    Aided Verification, Oxford, United Kingdom, 2018, vol. 10981, pp. 449–467.'
  ista: 'Kong H, Bartocci E, Henzinger TA. 2018. Reachable set over-approximation
    for nonlinear systems using piecewise barrier tubes. CAV: Computer Aided Verification,
    LNCS, vol. 10981, 449–467.'
  mla: Kong, Hui, et al. <i>Reachable Set Over-Approximation for Nonlinear Systems
    Using Piecewise Barrier Tubes</i>. Vol. 10981, Springer, 2018, pp. 449–67, doi:<a
    href="https://doi.org/10.1007/978-3-319-96145-3_24">10.1007/978-3-319-96145-3_24</a>.
  short: H. Kong, E. Bartocci, T.A. Henzinger, in:, Springer, 2018, pp. 449–467.
conference:
  end_date: 2018-07-17
  location: Oxford, United Kingdom
  name: 'CAV: Computer Aided Verification'
  start_date: 2018-07-14
date_created: 2018-12-11T11:44:51Z
date_published: 2018-07-18T00:00:00Z
date_updated: 2025-04-15T06:25:58Z
day: '18'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-96145-3_24
external_id:
  isi:
  - '000491481600024'
file:
- access_level: open_access
  checksum: fd95e8026deacef3dc752a733bb9355f
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T15:57:06Z
  date_updated: 2020-07-14T12:44:53Z
  file_id: '5718'
  file_name: 2018_LNCS_Kong.pdf
  file_size: 5591566
  relation: main_file
file_date_updated: 2020-07-14T12:44:53Z
has_accepted_license: '1'
intvolume: '     10981'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 449 - 467
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: Formal methods for the design and analysis of complex systems
publication_status: published
publisher: Springer
publist_id: '7781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reachable set over-approximation for nonlinear systems using piecewise barrier
  tubes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10981
year: '2018'
...
---
_id: '14201'
abstract:
- lang: eng
  text: "Variational inference is a popular technique to approximate a possibly\r\nintractable
    Bayesian posterior with a more tractable one. Recently, boosting\r\nvariational
    inference has been proposed as a new paradigm to approximate the\r\nposterior
    by a mixture of densities by greedily adding components to the\r\nmixture. However,
    as is the case with many other variational inference\r\nalgorithms, its theoretical
    properties have not been studied. In the present\r\nwork, we study the convergence
    properties of this approach from a modern\r\noptimization viewpoint by establishing
    connections to the classic Frank-Wolfe\r\nalgorithm. Our analyses yields novel
    theoretical insights regarding the\r\nsufficient conditions for convergence, explicit
    rates, and algorithmic\r\nsimplifications. Since a lot of focus in previous works
    for variational\r\ninference has been on tractability, our work is especially
    important as a much\r\nneeded attempt to bridge the gap between probabilistic
    models and their\r\ncorresponding theoretical properties."
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Rajiv
  full_name: Khanna, Rajiv
  last_name: Khanna
- first_name: Joydeep
  full_name: Ghosh, Joydeep
  last_name: Ghosh
- first_name: Gunnar
  full_name: Rätsch, Gunnar
  last_name: Rätsch
citation:
  ama: 'Locatello F, Khanna R, Ghosh J, Rätsch G. Boosting variational inference:
    An optimization perspective. In: <i>Proceedings of the 21st International Conference
    on Artificial Intelligence and Statistics</i>. Vol 84. ML Research Press; 2018:464-472.'
  apa: 'Locatello, F., Khanna, R., Ghosh, J., &#38; Rätsch, G. (2018). Boosting variational
    inference: An optimization perspective. In <i>Proceedings of the 21st International
    Conference on Artificial Intelligence and Statistics</i> (Vol. 84, pp. 464–472).
    Playa Blanca, Lanzarote: ML Research Press.'
  chicago: 'Locatello, Francesco, Rajiv Khanna, Joydeep Ghosh, and Gunnar Rätsch.
    “Boosting Variational Inference: An Optimization Perspective.” In <i>Proceedings
    of the 21st International Conference on Artificial Intelligence and Statistics</i>,
    84:464–72. ML Research Press, 2018.'
  ieee: 'F. Locatello, R. Khanna, J. Ghosh, and G. Rätsch, “Boosting variational inference:
    An optimization perspective,” in <i>Proceedings of the 21st International Conference
    on Artificial Intelligence and Statistics</i>, Playa Blanca, Lanzarote, 2018,
    vol. 84, pp. 464–472.'
  ista: 'Locatello F, Khanna R, Ghosh J, Rätsch G. 2018. Boosting variational inference:
    An optimization perspective. Proceedings of the 21st International Conference
    on Artificial Intelligence and Statistics. AISTATS: Conference on Artificial Intelligence
    and Statistics, PMLR, vol. 84, 464–472.'
  mla: 'Locatello, Francesco, et al. “Boosting Variational Inference: An Optimization
    Perspective.” <i>Proceedings of the 21st International Conference on Artificial
    Intelligence and Statistics</i>, vol. 84, ML Research Press, 2018, pp. 464–72.'
  short: F. Locatello, R. Khanna, J. Ghosh, G. Rätsch, in:, Proceedings of the 21st
    International Conference on Artificial Intelligence and Statistics, ML Research
    Press, 2018, pp. 464–472.
conference:
  end_date: 2018-04-11
  location: Playa Blanca, Lanzarote
  name: 'AISTATS: Conference on Artificial Intelligence and Statistics'
  start_date: 2018-04-09
date_created: 2023-08-22T14:15:20Z
date_published: 2018-04-15T00:00:00Z
date_updated: 2024-10-14T12:29:27Z
day: '15'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1708.01733'
intvolume: '        84'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1708.01733
month: '04'
oa: 1
oa_version: Preprint
page: 464-472
publication: Proceedings of the 21st International Conference on Artificial Intelligence
  and Statistics
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Boosting variational inference: An optimization perspective'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2018'
...
---
_id: '14202'
abstract:
- lang: eng
  text: "Approximating a probability density in a tractable manner is a central task\r\nin
    Bayesian statistics. Variational Inference (VI) is a popular technique that\r\nachieves
    tractability by choosing a relatively simple variational family.\r\nBorrowing
    ideas from the classic boosting framework, recent approaches attempt\r\nto \\emph{boost}
    VI by replacing the selection of a single density with a\r\ngreedily constructed
    mixture of densities. In order to guarantee convergence,\r\nprevious works impose
    stringent assumptions that require significant effort for\r\npractitioners. Specifically,
    they require a custom implementation of the greedy\r\nstep (called the LMO) for
    every probabilistic model with respect to an\r\nunnatural variational family of
    truncated distributions. Our work fixes these\r\nissues with novel theoretical
    and algorithmic insights. On the theoretical\r\nside, we show that boosting VI
    satisfies a relaxed smoothness assumption which\r\nis sufficient for the convergence
    of the functional Frank-Wolfe (FW) algorithm.\r\nFurthermore, we rephrase the
    LMO problem and propose to maximize the Residual\r\nELBO (RELBO) which replaces
    the standard ELBO optimization in VI. These\r\ntheoretical enhancements allow
    for black box implementation of the boosting\r\nsubroutine. Finally, we present
    a stopping criterion drawn from the duality gap\r\nin the classic FW analyses
    and exhaustive experiments to illustrate the\r\nusefulness of our theoretical
    and algorithmic contributions."
article_processing_charge: No
arxiv: 1
author:
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Gideon
  full_name: Dresdner, Gideon
  last_name: Dresdner
- first_name: Rajiv
  full_name: Khanna, Rajiv
  last_name: Khanna
- first_name: Isabel
  full_name: Valera, Isabel
  last_name: Valera
- first_name: Gunnar
  full_name: Rätsch, Gunnar
  last_name: Rätsch
citation:
  ama: 'Locatello F, Dresdner G, Khanna R, Valera I, Rätsch G. Boosting black box
    variational inference. In: <i>Advances in Neural Information Processing Systems</i>.
    Vol 31. Neural Information Processing Systems Foundation; 2018.'
  apa: 'Locatello, F., Dresdner, G., Khanna, R., Valera, I., &#38; Rätsch, G. (2018).
    Boosting black box variational inference. In <i>Advances in Neural Information
    Processing Systems</i> (Vol. 31). Montreal, Canada: Neural Information Processing
    Systems Foundation.'
  chicago: Locatello, Francesco, Gideon Dresdner, Rajiv Khanna, Isabel Valera, and
    Gunnar Rätsch. “Boosting Black Box Variational Inference.” In <i>Advances in Neural
    Information Processing Systems</i>, Vol. 31. Neural Information Processing Systems
    Foundation, 2018.
  ieee: F. Locatello, G. Dresdner, R. Khanna, I. Valera, and G. Rätsch, “Boosting
    black box variational inference,” in <i>Advances in Neural Information Processing
    Systems</i>, Montreal, Canada, 2018, vol. 31.
  ista: 'Locatello F, Dresdner G, Khanna R, Valera I, Rätsch G. 2018. Boosting black
    box variational inference. Advances in Neural Information Processing Systems.
    NeurIPS: Neural Information Processing Systems vol. 31.'
  mla: Locatello, Francesco, et al. “Boosting Black Box Variational Inference.” <i>Advances
    in Neural Information Processing Systems</i>, vol. 31, Neural Information Processing
    Systems Foundation, 2018.
  short: F. Locatello, G. Dresdner, R. Khanna, I. Valera, G. Rätsch, in:, Advances
    in Neural Information Processing Systems, Neural Information Processing Systems
    Foundation, 2018.
conference:
  end_date: 2018-12-08
  location: Montreal, Canada
  name: 'NeurIPS: Neural Information Processing Systems'
  start_date: 2018-12-03
date_created: 2023-08-22T14:15:40Z
date_published: 2018-06-06T00:00:00Z
date_updated: 2023-09-13T07:38:24Z
day: '06'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1806.02185'
intvolume: '        31'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1806.02185
month: '06'
oa: 1
oa_version: Preprint
publication: Advances in Neural Information Processing Systems
publication_identifier:
  eissn:
  - 1049-5258
  isbn:
  - '9781510884472'
publication_status: published
publisher: Neural Information Processing Systems Foundation
quality_controlled: '1'
scopus_import: '1'
status: public
title: Boosting black box variational inference
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2018'
...
---
_id: '14203'
abstract:
- lang: eng
  text: We propose a conditional gradient framework for a composite convex minimization
    template with broad applications. Our approach combines smoothing and homotopy
    techniques under the CGM framework, and provably achieves the optimal O(1/k−−√)
    convergence rate. We demonstrate that the same rate holds if the linear subproblems
    are solved approximately with additive or multiplicative error. In contrast with
    the relevant work, we are able to characterize the convergence when the non-smooth
    term is an indicator function. Specific applications of our framework include
    the non-smooth minimization, semidefinite programming, and minimization with linear
    inclusion constraints over a compact domain. Numerical evidence demonstrates the
    benefits of our framework.
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Alp
  full_name: Yurtsever, Alp
  last_name: Yurtsever
- first_name: Olivier
  full_name: Fercoq, Olivier
  last_name: Fercoq
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Volkan
  full_name: Cevher, Volkan
  last_name: Cevher
citation:
  ama: 'Yurtsever A, Fercoq O, Locatello F, Cevher V. A conditional gradient framework
    for composite convex minimization with applications to semidefinite programming.
    In: <i>Proceedings of the 35th International Conference on Machine Learning</i>.
    Vol 80. ML Research Press; 2018:5727-5736.'
  apa: 'Yurtsever, A., Fercoq, O., Locatello, F., &#38; Cevher, V. (2018). A conditional
    gradient framework for composite convex minimization with applications to semidefinite
    programming. In <i>Proceedings of the 35th International Conference on Machine
    Learning</i> (Vol. 80, pp. 5727–5736). Stockholm, Sweden: ML Research Press.'
  chicago: Yurtsever, Alp, Olivier Fercoq, Francesco Locatello, and Volkan Cevher.
    “A Conditional Gradient Framework for Composite Convex Minimization with Applications
    to Semidefinite Programming.” In <i>Proceedings of the 35th International Conference
    on Machine Learning</i>, 80:5727–36. ML Research Press, 2018.
  ieee: A. Yurtsever, O. Fercoq, F. Locatello, and V. Cevher, “A conditional gradient
    framework for composite convex minimization with applications to semidefinite
    programming,” in <i>Proceedings of the 35th International Conference on Machine
    Learning</i>, Stockholm, Sweden, 2018, vol. 80, pp. 5727–5736.
  ista: 'Yurtsever A, Fercoq O, Locatello F, Cevher V. 2018. A conditional gradient
    framework for composite convex minimization with applications to semidefinite
    programming. Proceedings of the 35th International Conference on Machine Learning.
    ICML: International Conference on Machine Learning, PMLR, vol. 80, 5727–5736.'
  mla: Yurtsever, Alp, et al. “A Conditional Gradient Framework for Composite Convex
    Minimization with Applications to Semidefinite Programming.” <i>Proceedings of
    the 35th International Conference on Machine Learning</i>, vol. 80, ML Research
    Press, 2018, pp. 5727–36.
  short: A. Yurtsever, O. Fercoq, F. Locatello, V. Cevher, in:, Proceedings of the
    35th International Conference on Machine Learning, ML Research Press, 2018, pp.
    5727–5736.
conference:
  end_date: 2018-07-15
  location: Stockholm, Sweden
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2018-07-10
date_created: 2023-08-22T14:16:01Z
date_published: 2018-07-15T00:00:00Z
date_updated: 2023-09-13T08:13:39Z
day: '15'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1804.08544'
intvolume: '        80'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1804.08544
month: '07'
oa: 1
oa_version: Preprint
page: 5727-5736
publication: Proceedings of the 35th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
status: public
title: A conditional gradient framework for composite convex minimization with applications
  to semidefinite programming
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2018'
...
---
_id: '14204'
abstract:
- lang: eng
  text: Two popular examples of first-order optimization methods over linear spaces
    are coordinate descent and matching pursuit algorithms, with their randomized
    variants. While the former targets the optimization by moving along coordinates,
    the latter considers a generalized notion of directions. Exploiting the connection
    between the two algorithms, we present a unified analysis of both, providing affine
    invariant sublinear O(1/t) rates on smooth objectives and linear convergence on
    strongly convex objectives. As a byproduct of our affine invariant analysis of
    matching pursuit, our rates for steepest coordinate descent are the tightest known.
    Furthermore, we show the first accelerated convergence rate O(1/t2) for matching
    pursuit and steepest coordinate descent on convex objectives.
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Anant
  full_name: Raj, Anant
  last_name: Raj
- first_name: Sai Praneeth
  full_name: Karimireddy, Sai Praneeth
  last_name: Karimireddy
- first_name: Gunnar
  full_name: Rätsch, Gunnar
  last_name: Rätsch
- first_name: Bernhard
  full_name: Schölkopf, Bernhard
  last_name: Schölkopf
- first_name: Sebastian U.
  full_name: Stich, Sebastian U.
  last_name: Stich
- first_name: Martin
  full_name: Jaggi, Martin
  last_name: Jaggi
citation:
  ama: 'Locatello F, Raj A, Karimireddy SP, et al. On matching pursuit and coordinate
    descent. In: <i>Proceedings of the 35th International Conference on Machine Learning</i>.
    Vol 80. ML Research Press; 2018:3198-3207.'
  apa: Locatello, F., Raj, A., Karimireddy, S. P., Rätsch, G., Schölkopf, B., Stich,
    S. U., &#38; Jaggi, M. (2018). On matching pursuit and coordinate descent. In
    <i>Proceedings of the 35th International Conference on Machine Learning</i> (Vol.
    80, pp. 3198–3207). ML Research Press.
  chicago: Locatello, Francesco, Anant Raj, Sai Praneeth Karimireddy, Gunnar Rätsch,
    Bernhard Schölkopf, Sebastian U. Stich, and Martin Jaggi. “On Matching Pursuit
    and Coordinate Descent.” In <i>Proceedings of the 35th International Conference
    on Machine Learning</i>, 80:3198–3207. ML Research Press, 2018.
  ieee: F. Locatello <i>et al.</i>, “On matching pursuit and coordinate descent,”
    in <i>Proceedings of the 35th International Conference on Machine Learning</i>,
    2018, vol. 80, pp. 3198–3207.
  ista: Locatello F, Raj A, Karimireddy SP, Rätsch G, Schölkopf B, Stich SU, Jaggi
    M. 2018. On matching pursuit and coordinate descent. Proceedings of the 35th International
    Conference on Machine Learning. , PMLR, vol. 80, 3198–3207.
  mla: Locatello, Francesco, et al. “On Matching Pursuit and Coordinate Descent.”
    <i>Proceedings of the 35th International Conference on Machine Learning</i>, vol.
    80, ML Research Press, 2018, pp. 3198–207.
  short: F. Locatello, A. Raj, S.P. Karimireddy, G. Rätsch, B. Schölkopf, S.U. Stich,
    M. Jaggi, in:, Proceedings of the 35th International Conference on Machine Learning,
    ML Research Press, 2018, pp. 3198–3207.
date_created: 2023-08-22T14:16:25Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2024-10-14T12:29:40Z
day: '01'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1803.09539'
intvolume: '        80'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.09539
month: '07'
oa: 1
oa_version: Preprint
page: 3198-3207
publication: Proceedings of the 35th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: On matching pursuit and coordinate descent
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2018'
...
---
_id: '14224'
abstract:
- lang: eng
  text: Clustering is a cornerstone of unsupervised learning which can be thought
    as disentangling multiple generative mechanisms underlying the data. In this paper
    we introduce an algorithmic framework to train mixtures of implicit generative
    models which we particularize for variational autoencoders. Relying on an additional
    set of discriminators, we propose a competitive procedure in which the models
    only need to approximate the portion of the data distribution from which they
    can produce realistic samples. As a byproduct, each model is simpler to train,
    and a clustering interpretation arises naturally from the partitioning of the
    training points among the models. We empirically show that our approach splits
    the training distribution in a reasonable way and increases the quality of the
    generated samples.
article_processing_charge: No
arxiv: 1
author:
- first_name: Francesco
  full_name: Locatello, Francesco
  id: 26cfd52f-2483-11ee-8040-88983bcc06d4
  last_name: Locatello
  orcid: 0000-0002-4850-0683
- first_name: Damien
  full_name: Vincent, Damien
  last_name: Vincent
- first_name: Ilya
  full_name: Tolstikhin, Ilya
  last_name: Tolstikhin
- first_name: Gunnar
  full_name: Ratsch, Gunnar
  last_name: Ratsch
- first_name: Sylvain
  full_name: Gelly, Sylvain
  last_name: Gelly
- first_name: Bernhard
  full_name: Scholkopf, Bernhard
  last_name: Scholkopf
citation:
  ama: 'Locatello F, Vincent D, Tolstikhin I, Ratsch G, Gelly S, Scholkopf B. Clustering
    meets implicit generative models. In: <i>6th International Conference on Learning
    Representations</i>. ; 2018.'
  apa: Locatello, F., Vincent, D., Tolstikhin, I., Ratsch, G., Gelly, S., &#38; Scholkopf,
    B. (2018). Clustering meets implicit generative models. In <i>6th International
    Conference on Learning Representations</i>. Vancouver, Canada.
  chicago: Locatello, Francesco, Damien Vincent, Ilya Tolstikhin, Gunnar Ratsch, Sylvain
    Gelly, and Bernhard Scholkopf. “Clustering Meets Implicit Generative Models.”
    In <i>6th International Conference on Learning Representations</i>, 2018.
  ieee: F. Locatello, D. Vincent, I. Tolstikhin, G. Ratsch, S. Gelly, and B. Scholkopf,
    “Clustering meets implicit generative models,” in <i>6th International Conference
    on Learning Representations</i>, Vancouver, Canada, 2018.
  ista: Locatello F, Vincent D, Tolstikhin I, Ratsch G, Gelly S, Scholkopf B. 2018.
    Clustering meets implicit generative models. 6th International Conference on Learning
    Representations. International Conference on Machine Learning.
  mla: Locatello, Francesco, et al. “Clustering Meets Implicit Generative Models.”
    <i>6th International Conference on Learning Representations</i>, 2018.
  short: F. Locatello, D. Vincent, I. Tolstikhin, G. Ratsch, S. Gelly, B. Scholkopf,
    in:, 6th International Conference on Learning Representations, 2018.
conference:
  end_date: 2018-05-03
  location: Vancouver, Canada
  name: International Conference on Machine Learning
  start_date: 2018-04-30
date_created: 2023-08-22T14:25:34Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2024-10-14T12:30:32Z
day: '01'
department:
- _id: FrLo
extern: '1'
external_id:
  arxiv:
  - '1804.11130'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1804.11130
month: '05'
oa: 1
oa_version: Preprint
publication: 6th International Conference on Learning Representations
publication_status: published
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clustering meets implicit generative models
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '143'
abstract:
- lang: eng
  text: 'Vector Addition Systems with States (VASS) provide a well-known and fundamental
    model for the analysis of concurrent processes, parameterized systems, and are
    also used as abstract models of programs in resource bound analysis. In this paper
    we study the problem of obtaining asymptotic bounds on the termination time of
    a given VASS. In particular, we focus on the practically important case of obtaining
    polynomial bounds on termination time. Our main contributions are as follows:
    First, we present a polynomial-time algorithm for deciding whether a given VASS
    has a linear asymptotic complexity. We also show that if the complexity of a VASS
    is not linear, it is at least quadratic. Second, we classify VASS according to
    quantitative properties of their cycles. We show that certain singularities in
    these properties are the key reason for non-polynomial asymptotic complexity of
    VASS. In absence of singularities, we show that the asymptotic complexity is always
    polynomial and of the form Θ(nk), for some integer k d, where d is the dimension
    of the VASS. We present a polynomial-time algorithm computing the optimal k. For
    general VASS, the same algorithm, which is based on a complete technique for the
    construction of ranking functions in VASS, produces a valid lower bound, i.e.,
    a k such that the termination complexity is (nk). Our results are based on new
    insights into the geometry of VASS dynamics, which hold the potential for further
    applicability to VASS analysis.'
alternative_title:
- ACM/IEEE Symposium on Logic in Computer Science
article_processing_charge: No
arxiv: 1
author:
- first_name: Tomáš
  full_name: Brázdil, Tomáš
  last_name: Brázdil
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Antonín
  full_name: Kučera, Antonín
  last_name: Kučera
- first_name: Petr
  full_name: Novotny, Petr
  id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
  last_name: Novotny
- first_name: Dominik
  full_name: Velan, Dominik
  last_name: Velan
- first_name: Florian
  full_name: Zuleger, Florian
  last_name: Zuleger
citation:
  ama: 'Brázdil T, Chatterjee K, Kučera A, Novotný P, Velan D, Zuleger F. Efficient
    algorithms for asymptotic bounds on termination time in VASS. In: Vol F138033.
    IEEE; 2018:185-194. doi:<a href="https://doi.org/10.1145/3209108.3209191">10.1145/3209108.3209191</a>'
  apa: 'Brázdil, T., Chatterjee, K., Kučera, A., Novotný, P., Velan, D., &#38; Zuleger,
    F. (2018). Efficient algorithms for asymptotic bounds on termination time in VASS
    (Vol. F138033, pp. 185–194). Presented at the LICS: Logic in Computer Science,
    Oxford, United Kingdom: IEEE. <a href="https://doi.org/10.1145/3209108.3209191">https://doi.org/10.1145/3209108.3209191</a>'
  chicago: Brázdil, Tomáš, Krishnendu Chatterjee, Antonín Kučera, Petr Novotný, Dominik
    Velan, and Florian Zuleger. “Efficient Algorithms for Asymptotic Bounds on Termination
    Time in VASS,” F138033:185–94. IEEE, 2018. <a href="https://doi.org/10.1145/3209108.3209191">https://doi.org/10.1145/3209108.3209191</a>.
  ieee: 'T. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, D. Velan, and F. Zuleger,
    “Efficient algorithms for asymptotic bounds on termination time in VASS,” presented
    at the LICS: Logic in Computer Science, Oxford, United Kingdom, 2018, vol. F138033,
    pp. 185–194.'
  ista: 'Brázdil T, Chatterjee K, Kučera A, Novotný P, Velan D, Zuleger F. 2018. Efficient
    algorithms for asymptotic bounds on termination time in VASS. LICS: Logic in Computer
    Science, ACM/IEEE Symposium on Logic in Computer Science, vol. F138033, 185–194.'
  mla: Brázdil, Tomáš, et al. <i>Efficient Algorithms for Asymptotic Bounds on Termination
    Time in VASS</i>. Vol. F138033, IEEE, 2018, pp. 185–94, doi:<a href="https://doi.org/10.1145/3209108.3209191">10.1145/3209108.3209191</a>.
  short: T. Brázdil, K. Chatterjee, A. Kučera, P. Novotný, D. Velan, F. Zuleger, in:,
    IEEE, 2018, pp. 185–194.
conference:
  end_date: 2018-07-12
  location: Oxford, United Kingdom
  name: 'LICS: Logic in Computer Science'
  start_date: 2018-07-09
date_created: 2018-12-11T11:44:51Z
date_published: 2018-07-09T00:00:00Z
date_updated: 2025-06-04T08:04:55Z
day: '09'
department:
- _id: KrCh
doi: 10.1145/3209108.3209191
ec_funded: 1
external_id:
  arxiv:
  - '1804.10985'
  isi:
  - '000545262800020'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1804.10985
month: '07'
oa: 1
oa_version: Preprint
page: 185 - 194
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication_identifier:
  isbn:
  - 978-1-4503-5583-4
publication_status: published
publisher: IEEE
publist_id: '7780'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient algorithms for asymptotic bounds on termination time in VASS
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: F138033
year: '2018'
...
