---
_id: '944'
abstract:
- lang: eng
text: The concerted production of neurons and glia by neural stem cells (NSCs) is
essential for neural circuit assembly. In the developing cerebral cortex, radial
glia progenitors (RGPs) generate nearly all neocortical neurons and certain glia
lineages. RGP proliferation behavior shows a high degree of non-stochasticity,
thus a deterministic characteristic of neuron and glia production. However, the
cellular and molecular mechanisms controlling RGP behavior and proliferation dynamics
in neurogenesis and glia generation remain unknown. By using mosaic analysis with
double markers (MADM)-based genetic paradigms enabling the sparse and global knockout
with unprecedented single-cell resolution, we identified Lgl1 as a critical regulatory
component. We uncover Lgl1-dependent tissue-wide community effects required for
embryonic cortical neurogenesis and novel cell-autonomous Lgl1 functions controlling
RGP-mediated glia genesis and postnatal NSC behavior. These results suggest that
NSC-mediated neuron and glia production is tightly regulated through the concerted
interplay of sequential Lgl1-dependent global and cell intrinsic mechanisms.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
article_processing_charge: No
author:
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Maria P
full_name: Postiglione, Maria P
id: 2C67902A-F248-11E8-B48F-1D18A9856A87
last_name: Postiglione
- first_name: Laura
full_name: Burnett, Laura
id: 3B717F68-F248-11E8-B48F-1D18A9856A87
last_name: Burnett
orcid: 0000-0002-8937-410X
- first_name: Susanne
full_name: Laukoter, Susanne
id: 2D6B7A9A-F248-11E8-B48F-1D18A9856A87
last_name: Laukoter
orcid: 0000-0002-7903-3010
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Guanxi
full_name: Xiao, Guanxi
last_name: Xiao
- first_name: Olga
full_name: Klezovitch, Olga
last_name: Klezovitch
- first_name: Valeri
full_name: Vasioukhin, Valeri
last_name: Vasioukhin
- first_name: Troy
full_name: Ghashghaei, Troy
last_name: Ghashghaei
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Beattie RJ, Postiglione MP, Burnett L, et al. Mosaic analysis with double markers
reveals distinct sequential functions of Lgl1 in neural stem cells. Neuron.
2017;94(3):517-533.e3. doi:10.1016/j.neuron.2017.04.012
apa: Beattie, R. J., Postiglione, M. P., Burnett, L., Laukoter, S., Streicher, C.,
Pauler, F., … Hippenmeyer, S. (2017). Mosaic analysis with double markers reveals
distinct sequential functions of Lgl1 in neural stem cells. Neuron. Cell
Press. https://doi.org/10.1016/j.neuron.2017.04.012
chicago: Beattie, Robert J, Maria P Postiglione, Laura Burnett, Susanne Laukoter,
Carmen Streicher, Florian Pauler, Guanxi Xiao, et al. “Mosaic Analysis with Double
Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells.” Neuron.
Cell Press, 2017. https://doi.org/10.1016/j.neuron.2017.04.012.
ieee: R. J. Beattie et al., “Mosaic analysis with double markers reveals
distinct sequential functions of Lgl1 in neural stem cells,” Neuron, vol.
94, no. 3. Cell Press, p. 517–533.e3, 2017.
ista: Beattie RJ, Postiglione MP, Burnett L, Laukoter S, Streicher C, Pauler F,
Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei T, Hippenmeyer S. 2017. Mosaic
analysis with double markers reveals distinct sequential functions of Lgl1 in
neural stem cells. Neuron. 94(3), 517–533.e3.
mla: Beattie, Robert J., et al. “Mosaic Analysis with Double Markers Reveals Distinct
Sequential Functions of Lgl1 in Neural Stem Cells.” Neuron, vol. 94, no.
3, Cell Press, 2017, p. 517–533.e3, doi:10.1016/j.neuron.2017.04.012.
short: R.J. Beattie, M.P. Postiglione, L. Burnett, S. Laukoter, C. Streicher, F.
Pauler, G. Xiao, O. Klezovitch, V. Vasioukhin, T. Ghashghaei, S. Hippenmeyer,
Neuron 94 (2017) 517–533.e3.
corr_author: '1'
date_created: 2018-12-11T11:49:20Z
date_published: 2017-05-03T00:00:00Z
date_updated: 2026-04-16T09:57:27Z
day: '03'
department:
- _id: SiHi
- _id: MaJö
doi: 10.1016/j.neuron.2017.04.012
ec_funded: 1
external_id:
isi:
- '000400466700011'
intvolume: ' 94'
isi: 1
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 517 - 533.e3
project:
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618444'
name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
grant_number: RGP0053/2014
name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
Level
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Cell Press
publist_id: '6473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mosaic analysis with double markers reveals distinct sequential functions of
Lgl1 in neural stem cells
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 94
year: '2017'
...
---
_id: '1016'
abstract:
- lang: eng
text: The integrity and dynamic properties of the microtubule cytoskeleton are indispensable
for the development of the mammalian brain. Consequently, mutations in the genes
that encode the structural component (the α/β-tubulin heterodimer) can give rise
to severe, sporadic neurodevelopmental disorders. These are commonly referred
to as the tubulinopathies. Here we report the addition of recessive quadrupedalism,
also known as Uner Tan syndrome (UTS), to the growing list of diseases caused
by tubulin variants. Analysis of a consanguineous UTS family identified a biallelic
TUBB2B mutation, resulting in a p.R390Q amino acid substitution. In addition to
the identifying quadrupedal locomotion, all three patients showed severe cerebellar
hypoplasia. None, however, displayed the basal ganglia malformations typically
associated with TUBB2B mutations. Functional analysis of the R390Q substitution
revealed that it did not affect the ability of β-tubulin to fold or become assembled
into the α/β-heterodimer, nor did it influence the incorporation of mutant-containing
heterodimers into microtubule polymers. The 390Q mutation in S. cerevisiae TUB2
did not affect growth under basal conditions, but did result in increased sensitivity
to microtubule-depolymerizing drugs, indicative of a mild impact of this mutation
on microtubule function. The TUBB2B mutation described here represents an unusual
recessive mode of inheritance for missense-mediated tubulinopathies and reinforces
the sensitivity of the developing cerebellum to microtubule defects.
article_processing_charge: No
author:
- first_name: Martin
full_name: Breuss, Martin
last_name: Breuss
- first_name: Thai
full_name: Nguyen, Thai
last_name: Nguyen
- first_name: Anjana
full_name: Srivatsan, Anjana
last_name: Srivatsan
- first_name: Ines
full_name: Leca, Ines
last_name: Leca
- first_name: Guoling
full_name: Tian, Guoling
last_name: Tian
- first_name: Tanja
full_name: Fritz, Tanja
last_name: Fritz
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Damir
full_name: Musaev, Damir
last_name: Musaev
- first_name: Jennifer
full_name: Mcevoy Venneri, Jennifer
last_name: Mcevoy Venneri
- first_name: James
full_name: Kiely, James
last_name: Kiely
- first_name: Rasim
full_name: Rosti, Rasim
last_name: Rosti
- first_name: Eric
full_name: Scott, Eric
last_name: Scott
- first_name: Uner
full_name: Tan, Uner
last_name: Tan
- first_name: Richard
full_name: Kolodner, Richard
last_name: Kolodner
- first_name: Nicholas
full_name: Cowan, Nicholas
last_name: Cowan
- first_name: David
full_name: Keays, David
last_name: Keays
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
citation:
ama: Breuss M, Nguyen T, Srivatsan A, et al. Uner Tan syndrome caused by a homozygous
TUBB2B mutation affecting microtubule stability. Human Molecular Genetics.
2017;26(2):258-269. doi:10.1093/hmg/ddw383
apa: Breuss, M., Nguyen, T., Srivatsan, A., Leca, I., Tian, G., Fritz, T., … Gleeson,
J. (2017). Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting
microtubule stability. Human Molecular Genetics. Oxford University Press.
https://doi.org/10.1093/hmg/ddw383
chicago: Breuss, Martin, Thai Nguyen, Anjana Srivatsan, Ines Leca, Guoling Tian,
Tanja Fritz, Andi H Hansen, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B
Mutation Affecting Microtubule Stability.” Human Molecular Genetics. Oxford
University Press, 2017. https://doi.org/10.1093/hmg/ddw383.
ieee: M. Breuss et al., “Uner Tan syndrome caused by a homozygous TUBB2B
mutation affecting microtubule stability,” Human Molecular Genetics, vol.
26, no. 2. Oxford University Press, pp. 258–269, 2017.
ista: Breuss M, Nguyen T, Srivatsan A, Leca I, Tian G, Fritz T, Hansen AH, Musaev
D, Mcevoy Venneri J, Kiely J, Rosti R, Scott E, Tan U, Kolodner R, Cowan N, Keays
D, Gleeson J. 2017. Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting
microtubule stability. Human Molecular Genetics. 26(2), 258–269.
mla: Breuss, Martin, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B Mutation
Affecting Microtubule Stability.” Human Molecular Genetics, vol. 26, no.
2, Oxford University Press, 2017, pp. 258–69, doi:10.1093/hmg/ddw383.
short: M. Breuss, T. Nguyen, A. Srivatsan, I. Leca, G. Tian, T. Fritz, A.H. Hansen,
D. Musaev, J. Mcevoy Venneri, J. Kiely, R. Rosti, E. Scott, U. Tan, R. Kolodner,
N. Cowan, D. Keays, J. Gleeson, Human Molecular Genetics 26 (2017) 258–269.
date_created: 2018-12-11T11:49:42Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2026-04-16T09:56:51Z
day: '01'
department:
- _id: SiHi
doi: 10.1093/hmg/ddw383
external_id:
isi:
- '000397066400002'
intvolume: ' 26'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 258 - 269
publication: Human Molecular Genetics
publication_identifier:
issn:
- 0964-6906
publication_status: published
publisher: Oxford University Press
publist_id: '6379'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule
stability
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 26
year: '2017'
...
---
_id: '1026'
abstract:
- lang: eng
text: The optogenetic revolution enabled spatially-precise and temporally-precise
control over protein function, signaling pathway activation, and animal behavior
with tremendous success in the dissection of signaling networks and neural circuits.
Very recently, optogenetic methods have been paired with optical reporters in
novel drug screening platforms. In these all-optical platforms, light remotely
activated ion channels and kinases thereby obviating the use of electrophysiology
or reagents. Consequences were remarkable operational simplicity, throughput,
and cost-effectiveness that culminated in the identification of new drug candidates.
These blueprints for all-optical assays also revealed potential pitfalls and inspire
all-optical variants of other screens, such as those that aim at better understanding
dynamic drug action or orphan protein function.
acknowledgement: This work was supported by grants of the European Union Seventh Framework
Programme (CIG-303564), the Human Frontier Science Program (RGY0084_2012), and the
Austrian Science Fund FWF (W1232 MolecularDrugTargets).
article_processing_charge: No
article_type: original
author:
- first_name: Viviana
full_name: Agus, Viviana
last_name: Agus
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: 'Agus V, Janovjak HL. Optogenetic methods in drug screening: Technologies and
applications. Current Opinion in Biotechnology. 2017;48:8-14. doi:10.1016/j.copbio.2017.02.006'
apa: 'Agus, V., & Janovjak, H. L. (2017). Optogenetic methods in drug screening:
Technologies and applications. Current Opinion in Biotechnology. Elsevier.
https://doi.org/10.1016/j.copbio.2017.02.006'
chicago: 'Agus, Viviana, and Harald L Janovjak. “Optogenetic Methods in Drug Screening:
Technologies and Applications.” Current Opinion in Biotechnology. Elsevier,
2017. https://doi.org/10.1016/j.copbio.2017.02.006.'
ieee: 'V. Agus and H. L. Janovjak, “Optogenetic methods in drug screening: Technologies
and applications,” Current Opinion in Biotechnology, vol. 48. Elsevier,
pp. 8–14, 2017.'
ista: 'Agus V, Janovjak HL. 2017. Optogenetic methods in drug screening: Technologies
and applications. Current Opinion in Biotechnology. 48, 8–14.'
mla: 'Agus, Viviana, and Harald L. Janovjak. “Optogenetic Methods in Drug Screening:
Technologies and Applications.” Current Opinion in Biotechnology, vol.
48, Elsevier, 2017, pp. 8–14, doi:10.1016/j.copbio.2017.02.006.'
short: V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
corr_author: '1'
date_created: 2018-12-11T11:49:45Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2026-04-16T09:57:03Z
day: '01'
department:
- _id: HaJa
doi: 10.1016/j.copbio.2017.02.006
ec_funded: 1
external_id:
isi:
- '000418313200003'
intvolume: ' 48'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
page: 8 - 14
project:
- _id: 255BFFFA-B435-11E9-9278-68D0E5697425
grant_number: RGY0084/2012
name: In situ real-time imaging of neurotransmitter signaling using designer optical
sensors
- _id: 25548C20-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303564'
name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 255A6082-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: Current Opinion in Biotechnology
publication_identifier:
issn:
- 0958-1669
publication_status: published
publisher: Elsevier
publist_id: '6365'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Optogenetic methods in drug screening: Technologies and applications'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 48
year: '2017'
...
---
_id: '1084'
abstract:
- lang: eng
text: 'BceRS and PsdRS are paralogous two-component systems in Bacillus subtilis
controlling the response to antimicrobial peptides. In the presence of extracellular
bacitracin and nisin, respectively, the two response regulators (RRs) bind their
target promoters, PbceA or PpsdA, resulting in a strong up-regulation of target
gene expression and ultimately antibiotic resistance. Despite high sequence similarity
between the RRs BceR and PsdR and their known binding sites, no cross-regulation
has been observed between them. We therefore investigated the specificity determinants
of PbceA and PpsdA that ensure the insulation of these two paralogous pathways
at the RR–promoter interface. In vivo and in vitro analyses demonstrate that the
regulatory regions within these two promoters contain three important elements:
in addition to the known (main) binding site, we identified a linker region and
a secondary binding site that are crucial for functionality. Initial binding to
the high-affinity, low-specificity main binding site is a prerequisite for the
subsequent highly specific binding of a second RR dimer to the low-affinity secondary
binding site. In addition to this hierarchical cooperative binding, discrimination
requires a competition of the two RRs for their respective binding site mediated
by only slight differences in binding affinities.'
article_processing_charge: No
author:
- first_name: Chong
full_name: Fang, Chong
last_name: Fang
- first_name: Anna A
full_name: Nagy-Staron, Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
orcid: 0000-0002-1391-8377
- first_name: Martin
full_name: Grafe, Martin
last_name: Grafe
- first_name: Ralf
full_name: Heermann, Ralf
last_name: Heermann
- first_name: Kirsten
full_name: Jung, Kirsten
last_name: Jung
- first_name: Susanne
full_name: Gebhard, Susanne
last_name: Gebhard
- first_name: Thorsten
full_name: Mascher, Thorsten
last_name: Mascher
citation:
ama: Fang C, Nagy-Staron AA, Grafe M, et al. Insulation and wiring specificity of
BceR like response regulators and their target promoters in Bacillus subtilis.
Molecular Microbiology. 2017;104(1):16-31. doi:10.1111/mmi.13597
apa: Fang, C., Nagy-Staron, A. A., Grafe, M., Heermann, R., Jung, K., Gebhard, S.,
& Mascher, T. (2017). Insulation and wiring specificity of BceR like response
regulators and their target promoters in Bacillus subtilis. Molecular Microbiology.
Wiley-Blackwell. https://doi.org/10.1111/mmi.13597
chicago: Fang, Chong, Anna A Nagy-Staron, Martin Grafe, Ralf Heermann, Kirsten Jung,
Susanne Gebhard, and Thorsten Mascher. “Insulation and Wiring Specificity of BceR
like Response Regulators and Their Target Promoters in Bacillus Subtilis.” Molecular
Microbiology. Wiley-Blackwell, 2017. https://doi.org/10.1111/mmi.13597.
ieee: C. Fang et al., “Insulation and wiring specificity of BceR like response
regulators and their target promoters in Bacillus subtilis,” Molecular Microbiology,
vol. 104, no. 1. Wiley-Blackwell, pp. 16–31, 2017.
ista: Fang C, Nagy-Staron AA, Grafe M, Heermann R, Jung K, Gebhard S, Mascher T.
2017. Insulation and wiring specificity of BceR like response regulators and their
target promoters in Bacillus subtilis. Molecular Microbiology. 104(1), 16–31.
mla: Fang, Chong, et al. “Insulation and Wiring Specificity of BceR like Response
Regulators and Their Target Promoters in Bacillus Subtilis.” Molecular Microbiology,
vol. 104, no. 1, Wiley-Blackwell, 2017, pp. 16–31, doi:10.1111/mmi.13597.
short: C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T.
Mascher, Molecular Microbiology 104 (2017) 16–31.
date_created: 2018-12-11T11:50:03Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2026-04-16T09:56:09Z
day: '01'
department:
- _id: CaGu
doi: 10.1111/mmi.13597
external_id:
isi:
- '000398059200002'
intvolume: ' 104'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa_version: None
page: 16 - 31
publication: Molecular Microbiology
publication_identifier:
issn:
- ' 0950-382X'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6294'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Insulation and wiring specificity of BceR like response regulators and their
target promoters in Bacillus subtilis
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 104
year: '2017'
...
---
_id: '793'
abstract:
- lang: eng
text: 'Let P be a finite point set in the plane. A cordinary triangle in P is a
subset of P consisting of three non-collinear points such that each of the three
lines determined by the three points contains at most c points of P . Motivated
by a question of Erdös, and answering a question of de Zeeuw, we prove that there
exists a constant c > 0such that P contains a c-ordinary triangle, provided
that P is not contained in the union of two lines. Furthermore, the number of
c-ordinary triangles in P is Ω(| P |). '
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
full_name: Fulek, Radoslav
id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
last_name: Fulek
orcid: 0000-0001-8485-1774
- first_name: Hossein
full_name: Mojarrad, Hossein
last_name: Mojarrad
- first_name: Márton
full_name: Naszódi, Márton
last_name: Naszódi
- first_name: József
full_name: Solymosi, József
last_name: Solymosi
- first_name: Sebastian
full_name: Stich, Sebastian
last_name: Stich
- first_name: May
full_name: Szedlák, May
last_name: Szedlák
citation:
ama: 'Fulek R, Mojarrad H, Naszódi M, Solymosi J, Stich S, Szedlák M. On the existence
of ordinary triangles. Computational Geometry: Theory and Applications.
2017;66:28-31. doi:10.1016/j.comgeo.2017.07.002'
apa: 'Fulek, R., Mojarrad, H., Naszódi, M., Solymosi, J., Stich, S., & Szedlák,
M. (2017). On the existence of ordinary triangles. Computational Geometry:
Theory and Applications. Elsevier. https://doi.org/10.1016/j.comgeo.2017.07.002'
chicago: 'Fulek, Radoslav, Hossein Mojarrad, Márton Naszódi, József Solymosi, Sebastian
Stich, and May Szedlák. “On the Existence of Ordinary Triangles.” Computational
Geometry: Theory and Applications. Elsevier, 2017. https://doi.org/10.1016/j.comgeo.2017.07.002.'
ieee: 'R. Fulek, H. Mojarrad, M. Naszódi, J. Solymosi, S. Stich, and M. Szedlák,
“On the existence of ordinary triangles,” Computational Geometry: Theory and
Applications, vol. 66. Elsevier, pp. 28–31, 2017.'
ista: 'Fulek R, Mojarrad H, Naszódi M, Solymosi J, Stich S, Szedlák M. 2017. On
the existence of ordinary triangles. Computational Geometry: Theory and Applications.
66, 28–31.'
mla: 'Fulek, Radoslav, et al. “On the Existence of Ordinary Triangles.” Computational
Geometry: Theory and Applications, vol. 66, Elsevier, 2017, pp. 28–31, doi:10.1016/j.comgeo.2017.07.002.'
short: 'R. Fulek, H. Mojarrad, M. Naszódi, J. Solymosi, S. Stich, M. Szedlák, Computational
Geometry: Theory and Applications 66 (2017) 28–31.'
date_created: 2018-12-11T11:48:32Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2026-04-16T09:57:17Z
day: '01'
department:
- _id: UlWa
doi: 10.1016/j.comgeo.2017.07.002
ec_funded: 1
external_id:
arxiv:
- '1701.08183'
isi:
- '000412039700003'
intvolume: ' 66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1701.08183
month: '01'
oa: 1
oa_version: Submitted Version
page: 28 - 31
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '6861'
quality_controlled: '1'
status: public
title: On the existence of ordinary triangles
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 66
year: '2017'
...
---
_id: '945'
abstract:
- lang: eng
text: While chromosome-wide dosage compensation of the X chromosome has been found
in many species, studies in ZW clades have indicated that compensation of the
Z is more localized and/or incomplete. In the ZW Lepidoptera, some species show
complete compensation of the Z chromosome, while others lack full equalization,
but what drives these inconsistencies is unclear. Here, we compare patterns of
male and female gene expression on the Z chromosome of two closely related butterfly
species, Papilio xuthus and Papilio machaon, and in multiple tissues of two moths
species, Plodia interpunctella and Bombyx mori, which were previously found to
differ in the extent to which they equalize Z-linked gene expression between the
sexes. We find that, while some species and tissues seem to have incomplete dosage
compensation, this is in fact due to the accumulation of male-biased genes and
the depletion of female-biased genes on the Z chromosome. Once this is accounted
for, the Z chromosome is fully compensated in all four species, through the up-regulation
of Z expression in females and in some cases additional down-regulation in males.
We further find that both sex-biased genes and Z-linked genes have increased rates
of expression divergence in this clade, and that this can lead to fast shifts
in patterns of gene expression even between closely related species. Taken together,
these results show that the uneven distribution of sex-biased genes on sex chromosomes
can confound conclusions about dosage compensation and that Z chromosome-wide
dosage compensation is not only possible but ubiquitous among Lepidoptera.
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Ann K
full_name: Huylmans, Ann K
id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
last_name: Huylmans
orcid: 0000-0001-8871-4961
- first_name: Ariana
full_name: Macon, Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Huylmans AK, Macon A, Vicoso B. Global dosage compensation is ubiquitous in
Lepidoptera, but counteracted by the masculinization of the Z chromosome. Molecular
Biology and Evolution. 2017;34(10):2637-2649. doi:10.1093/molbev/msx190
apa: Huylmans, A. K., Macon, A., & Vicoso, B. (2017). Global dosage compensation
is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z
chromosome. Molecular Biology and Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msx190
chicago: Huylmans, Ann K, Ariana Macon, and Beatriz Vicoso. “Global Dosage Compensation
Is Ubiquitous in Lepidoptera, but Counteracted by the Masculinization of the Z
Chromosome.” Molecular Biology and Evolution. Oxford University Press,
2017. https://doi.org/10.1093/molbev/msx190.
ieee: A. K. Huylmans, A. Macon, and B. Vicoso, “Global dosage compensation is ubiquitous
in Lepidoptera, but counteracted by the masculinization of the Z chromosome,”
Molecular Biology and Evolution, vol. 34, no. 10. Oxford University Press,
pp. 2637–2649, 2017.
ista: Huylmans AK, Macon A, Vicoso B. 2017. Global dosage compensation is ubiquitous
in Lepidoptera, but counteracted by the masculinization of the Z chromosome. Molecular
Biology and Evolution. 34(10), 2637–2649.
mla: Huylmans, Ann K., et al. “Global Dosage Compensation Is Ubiquitous in Lepidoptera,
but Counteracted by the Masculinization of the Z Chromosome.” Molecular Biology
and Evolution, vol. 34, no. 10, Oxford University Press, 2017, pp. 2637–49,
doi:10.1093/molbev/msx190.
short: A.K. Huylmans, A. Macon, B. Vicoso, Molecular Biology and Evolution 34 (2017)
2637–2649.
date_created: 2018-12-11T11:49:20Z
date_published: 2017-07-06T00:00:00Z
date_updated: 2026-04-16T09:58:19Z
day: '06'
ddc:
- '570'
- '576'
department:
- _id: BeVi
doi: 10.1093/molbev/msx190
external_id:
isi:
- '000411814800016'
file:
- access_level: open_access
checksum: 009fd68043211d645ceb9d1de28274f2
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:23Z
date_updated: 2020-07-14T12:48:15Z
file_id: '4810'
file_name: IST-2017-848-v1+1_2017_Vicoso_GlobalDosage.pdf
file_size: 462863
relation: main_file
file_date_updated: 2020-07-14T12:48:15Z
has_accepted_license: '1'
intvolume: ' 34'
isi: 1
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 2637 - 2649
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28842-B22
name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular Biology and Evolution
publication_identifier:
issn:
- 0737-4038
publication_status: published
publisher: Oxford University Press
publist_id: '6472'
pubrep_id: '848'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by
the masculinization of the Z chromosome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 34
year: '2017'
...
---
_id: '557'
abstract:
- lang: eng
text: PURPOSE. Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful
therapeutic for the rescue and regeneration of these cells after optic nerve damage.
However, early after damage, RGCs undergo atrophic changes, including gene silencing.
It is not known if these changes will deleteriously affect transduction and transgene
expression, or if the therapeutic protein can influence reactivation of the endogenous
genome. METHODS. Double-transgenic mice carrying a Rosa26-(LoxP)-tdTomato reporter,
and a mutant allele for the proapoptotic Bax gene were reared. The Bax mutant
blocks apoptosis, but RGCs still exhibit nuclear atrophy and gene silencing. At
times ranging from 1 hour to 4 weeks after optic nerve crush (ONC), eyes received
an intravitreal injection of AAV2 virus carrying the Cre recombinase. Successful
transduction was monitored by expression of the tdTomato reporter. Immunostaining
was used to localize tdTomato expression in select cell types. RESULTS. Successful
transduction of RGCs was achieved at all time points after ONC using AAV2 expressing
Cre from the phosphoglycerate kinase (Pgk) promoter, but not the CMV promoter.
ONC promoted an increase in the transduction of cell types in the inner nuclear
layer, including Müller cells and rod bipolar neurons. There was minimal evidence
of transduction of amacrine cells and astrocytes in the inner retina or optic
nerve. CONCLUSIONS. Damaged RGCs can be transduced and at least some endogenous
genes can be subsequently activated. Optic nerve damage may change retinal architecture
to allow greater penetration of an AAV2 virus to transduce several additional
cell types in the inner nuclear layer.
article_processing_charge: No
author:
- first_name: Robert
full_name: Nickells, Robert
last_name: Nickells
- first_name: Heather
full_name: Schmitt, Heather
last_name: Schmitt
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: Cassandra
full_name: Schlamp, Cassandra
last_name: Schlamp
citation:
ama: Nickells R, Schmitt H, Maes ME, Schlamp C. AAV2 mediated transduction of the
mouse retina after optic nerve injury. Investigative Ophthalmology and Visual
Science. 2017;58(14):6091-6104. doi:10.1167/iovs.17-22634
apa: Nickells, R., Schmitt, H., Maes, M. E., & Schlamp, C. (2017). AAV2 mediated
transduction of the mouse retina after optic nerve injury. Investigative Ophthalmology
and Visual Science. Association for Research in Vision and Ophthalmology.
https://doi.org/10.1167/iovs.17-22634
chicago: Nickells, Robert, Heather Schmitt, Margaret E Maes, and Cassandra Schlamp.
“AAV2 Mediated Transduction of the Mouse Retina after Optic Nerve Injury.” Investigative
Ophthalmology and Visual Science. Association for Research in Vision and Ophthalmology,
2017. https://doi.org/10.1167/iovs.17-22634.
ieee: R. Nickells, H. Schmitt, M. E. Maes, and C. Schlamp, “AAV2 mediated transduction
of the mouse retina after optic nerve injury,” Investigative Ophthalmology
and Visual Science, vol. 58, no. 14. Association for Research in Vision and
Ophthalmology, pp. 6091–6104, 2017.
ista: Nickells R, Schmitt H, Maes ME, Schlamp C. 2017. AAV2 mediated transduction
of the mouse retina after optic nerve injury. Investigative Ophthalmology and
Visual Science. 58(14), 6091–6104.
mla: Nickells, Robert, et al. “AAV2 Mediated Transduction of the Mouse Retina after
Optic Nerve Injury.” Investigative Ophthalmology and Visual Science, vol.
58, no. 14, Association for Research in Vision and Ophthalmology, 2017, pp. 6091–104,
doi:10.1167/iovs.17-22634.
short: R. Nickells, H. Schmitt, M.E. Maes, C. Schlamp, Investigative Ophthalmology
and Visual Science 58 (2017) 6091–6104.
date_created: 2018-12-11T11:47:10Z
date_published: 2017-12-14T00:00:00Z
date_updated: 2026-04-16T09:58:51Z
day: '14'
ddc:
- '576'
department:
- _id: SaSi
doi: 10.1167/iovs.17-22634
external_id:
isi:
- '000426781300012'
file:
- access_level: open_access
checksum: d7a7b6f1fa9211a04e5e65634a0265d9
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:53Z
date_updated: 2020-07-14T12:47:04Z
file_id: '5311'
file_name: IST-2018-920-v1+1_i1552-5783-58-14-6091.pdf
file_size: 2955559
relation: main_file
file_date_updated: 2020-07-14T12:47:04Z
has_accepted_license: '1'
intvolume: ' 58'
isi: 1
issue: '14'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 6091 - 6104
publication: Investigative Ophthalmology and Visual Science
publication_identifier:
issn:
- 0146-0404
publication_status: published
publisher: Association for Research in Vision and Ophthalmology
publist_id: '7254'
pubrep_id: '920'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AAV2 mediated transduction of the mouse retina after optic nerve injury
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 58
year: '2017'
...
---
_id: '470'
abstract:
- lang: eng
text: This paper presents a method for simulating water surface waves as a displacement
field on a 2D domain. Our method relies on Lagrangian particles that carry packets
of water wave energy; each packet carries information about an entire group of
wave trains, as opposed to only a single wave crest. Our approach is unconditionally
stable and can simulate high resolution geometric details. This approach also
presents a straightforward interface for artistic control, because it is essentially
a particle system with intuitive parameters like wavelength and amplitude. Our
implementation parallelizes well and runs in real time for moderately challenging
scenarios.
acknowledged_ssus:
- _id: ScienComp
article_number: '103'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Stefan
full_name: Jeschke, Stefan
id: 44D6411A-F248-11E8-B48F-1D18A9856A87
last_name: Jeschke
orcid: 0000-0003-4330-8884
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Jeschke S, Wojtan C. Water wave packets. ACM Transactions on Graphics.
2017;36(4). doi:10.1145/3072959.3073678
apa: Jeschke, S., & Wojtan, C. (2017). Water wave packets. ACM Transactions
on Graphics. ACM. https://doi.org/10.1145/3072959.3073678
chicago: Jeschke, Stefan, and Chris Wojtan. “Water Wave Packets.” ACM Transactions
on Graphics. ACM, 2017. https://doi.org/10.1145/3072959.3073678.
ieee: S. Jeschke and C. Wojtan, “Water wave packets,” ACM Transactions on Graphics,
vol. 36, no. 4. ACM, 2017.
ista: Jeschke S, Wojtan C. 2017. Water wave packets. ACM Transactions on Graphics.
36(4), 103.
mla: Jeschke, Stefan, and Chris Wojtan. “Water Wave Packets.” ACM Transactions
on Graphics, vol. 36, no. 4, 103, ACM, 2017, doi:10.1145/3072959.3073678.
short: S. Jeschke, C. Wojtan, ACM Transactions on Graphics 36 (2017).
date_created: 2018-12-11T11:46:39Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2026-04-16T09:58:39Z
day: '01'
ddc:
- '006'
department:
- _id: ChWo
doi: 10.1145/3072959.3073678
ec_funded: 1
external_id:
isi:
- '000406432100071'
file:
- access_level: open_access
checksum: 82a3b2bfeee4ddef16ecc21675d1a48a
content_type: application/pdf
creator: wojtan
date_created: 2020-01-24T09:32:35Z
date_updated: 2020-07-14T12:46:34Z
file_id: '7359'
file_name: wavepackets_final.pdf
file_size: 13131683
relation: main_file
file_date_updated: 2020-07-14T12:46:34Z
has_accepted_license: '1'
intvolume: ' 36'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: 'Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large
Scales'
publication: ACM Transactions on Graphics
publication_identifier:
issn:
- 0730-0301
publication_status: published
publisher: ACM
publist_id: '7350'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Water wave packets
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 36
year: '2017'
...
---
_id: '654'
abstract:
- lang: eng
text: In November 2016, developmental biologists, synthetic biologists and engineers
gathered in Paris for a meeting called ‘Engineering the embryo’. The participants
shared an interest in exploring how synthetic systems can reveal new principles
of embryonic development, and how the in vitro manipulation and modeling of development
using stem cells can be used to integrate ideas and expertise from physics, developmental
biology and tissue engineering. As we review here, the conference pinpointed some
of the challenges arising at the intersection of these fields, along with great
enthusiasm for finding new approaches and collaborations.
article_processing_charge: No
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Nicolas
full_name: Rivron, Nicolas
last_name: Rivron
citation:
ama: Kicheva A, Rivron N. Creating to understand – developmental biology meets engineering
in Paris. Development. 2017;144(5):733-736. doi:10.1242/dev.144915
apa: Kicheva, A., & Rivron, N. (2017). Creating to understand – developmental
biology meets engineering in Paris. Development. Company of Biologists.
https://doi.org/10.1242/dev.144915
chicago: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development. Company of Biologists,
2017. https://doi.org/10.1242/dev.144915.
ieee: A. Kicheva and N. Rivron, “Creating to understand – developmental biology
meets engineering in Paris,” Development, vol. 144, no. 5. Company of Biologists,
pp. 733–736, 2017.
ista: Kicheva A, Rivron N. 2017. Creating to understand – developmental biology
meets engineering in Paris. Development. 144(5), 733–736.
mla: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development, vol. 144, no. 5, Company
of Biologists, 2017, pp. 733–36, doi:10.1242/dev.144915.
short: A. Kicheva, N. Rivron, Development 144 (2017) 733–736.
corr_author: '1'
date_created: 2018-12-11T11:47:44Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2026-04-16T09:59:52Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1242/dev.144915
ec_funded: 1
external_id:
isi:
- '000395650100001'
file:
- access_level: open_access
checksum: eef22a0f42a55b232cb2d1188a2322cb
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:20Z
date_updated: 2020-07-14T12:47:33Z
file_id: '5139'
file_name: IST-2018-987-v1+1_2017_KichevaRivron__Creating_to.pdf
file_size: 228206
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 144'
isi: 1
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 733 - 736
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '7089'
pubrep_id: '987'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Creating to understand – developmental biology meets engineering in Paris
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 144
year: '2017'
...
---
_id: '623'
abstract:
- lang: eng
text: Genetic factors might be largely responsible for the development of autism
spectrum disorder (ASD) that alone or in combination with specific environmental
risk factors trigger the pathology. Multiple mutations identified in ASD patients
that impair synaptic function in the central nervous system are well studied in
animal models. How these mutations might interact with other risk factors is not
fully understood though. Additionally, how systems outside of the brain are altered
in the context of ASD is an emerging area of research. Extracerebral influences
on the physiology could begin in utero and contribute to changes in the brain
and in the development of other body systems and further lead to epigenetic changes.
Therefore, multiple recent studies have aimed at elucidating the role of gene-environment
interactions in ASD. Here we provide an overview on the extracerebral systems
that might play an important associative role in ASD and review evidence regarding
the potential roles of inflammation, trace metals, metabolism, genetic susceptibility,
enteric nervous system function and the microbiota of the gastrointestinal (GI)
tract on the development of endophenotypes in animal models of ASD. By influencing
environmental conditions, it might be possible to reduce or limit the severity
of ASD pathology.
alternative_title:
- ADVSANAT
article_processing_charge: No
author:
- first_name: Elisa
full_name: Hill Yardin, Elisa
last_name: Hill Yardin
- first_name: Sonja
full_name: Mckeown, Sonja
last_name: Mckeown
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Andreas
full_name: Grabrucker, Andreas
last_name: Grabrucker
citation:
ama: 'Hill Yardin E, Mckeown S, Novarino G, Grabrucker A. Extracerebral dysfunction
in animal models of autism spectrum disorder. In: Schmeisser M, Boekers T, eds.
Translational Anatomy and Cell Biology of Autism Spectrum Disorder. Vol
224. Advances in Anatomy Embryology and Cell Biology. Springer; 2017:159-187.
doi:10.1007/978-3-319-52498-6_9'
apa: Hill Yardin, E., Mckeown, S., Novarino, G., & Grabrucker, A. (2017). Extracerebral
dysfunction in animal models of autism spectrum disorder. In M. Schmeisser &
T. Boekers (Eds.), Translational Anatomy and Cell Biology of Autism Spectrum
Disorder (Vol. 224, pp. 159–187). Springer. https://doi.org/10.1007/978-3-319-52498-6_9
chicago: Hill Yardin, Elisa, Sonja Mckeown, Gaia Novarino, and Andreas Grabrucker.
“Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder.” In Translational
Anatomy and Cell Biology of Autism Spectrum Disorder, edited by Michael Schmeisser
and Tobias Boekers, 224:159–87. Advances in Anatomy Embryology and Cell Biology.
Springer, 2017. https://doi.org/10.1007/978-3-319-52498-6_9.
ieee: E. Hill Yardin, S. Mckeown, G. Novarino, and A. Grabrucker, “Extracerebral
dysfunction in animal models of autism spectrum disorder,” in Translational
Anatomy and Cell Biology of Autism Spectrum Disorder, vol. 224, M. Schmeisser
and T. Boekers, Eds. Springer, 2017, pp. 159–187.
ista: 'Hill Yardin E, Mckeown S, Novarino G, Grabrucker A. 2017.Extracerebral dysfunction
in animal models of autism spectrum disorder. In: Translational Anatomy and Cell
Biology of Autism Spectrum Disorder. ADVSANAT, vol. 224, 159–187.'
mla: Hill Yardin, Elisa, et al. “Extracerebral Dysfunction in Animal Models of Autism
Spectrum Disorder.” Translational Anatomy and Cell Biology of Autism Spectrum
Disorder, edited by Michael Schmeisser and Tobias Boekers, vol. 224, Springer,
2017, pp. 159–87, doi:10.1007/978-3-319-52498-6_9.
short: E. Hill Yardin, S. Mckeown, G. Novarino, A. Grabrucker, in:, M. Schmeisser,
T. Boekers (Eds.), Translational Anatomy and Cell Biology of Autism Spectrum Disorder,
Springer, 2017, pp. 159–187.
date_created: 2018-12-11T11:47:33Z
date_published: 2017-05-28T00:00:00Z
date_updated: 2026-04-16T09:59:22Z
day: '28'
department:
- _id: GaNo
doi: 10.1007/978-3-319-52498-6_9
editor:
- first_name: Michael
full_name: Schmeisser, Michael
last_name: Schmeisser
- first_name: Tobias
full_name: Boekers, Tobias
last_name: Boekers
external_id:
isi:
- '000443802500010'
intvolume: ' 224'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
page: 159 - 187
publication: Translational Anatomy and Cell Biology of Autism Spectrum Disorder
publication_identifier:
isbn:
- '9783319524962'
issn:
- 0301-5556
publication_status: published
publisher: Springer
publist_id: '7177'
quality_controlled: '1'
scopus_import: '1'
series_title: Advances in Anatomy Embryology and Cell Biology
status: public
title: Extracerebral dysfunction in animal models of autism spectrum disorder
type: book_chapter
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 224
year: '2017'
...
---
_id: '962'
abstract:
- lang: eng
text: 'We present a new algorithm for model counting of a class of string constraints.
In addition to the classic operation of concatenation, our class includes some
recursively defined operations such as Kleene closure, and replacement of substrings.
Additionally, our class also includes length constraints on the string expressions,
which means, by requiring reasoning about numbers, that we face a multi-sorted
logic. In the end, our string constraints are motivated by their use in programming
for web applications. Our algorithm comprises two novel features: the ability
to use a technique of (1) partial derivatives for constraints that are already
in a solved form, i.e. a form where its (string) satisfiability is clearly displayed,
and (2) non-progression, where cyclic reasoning in the reduction process may be
terminated (thus allowing for the algorithm to look elsewhere). Finally, we experimentally
compare our model counter with two recent works on model counting of similar constraints,
SMC [18] and ABC [5], to demonstrate its superior performance.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Minh
full_name: Trinh, Minh
last_name: Trinh
- first_name: Duc Hiep
full_name: Chu, Duc Hiep
id: 3598E630-F248-11E8-B48F-1D18A9856A87
last_name: Chu
- first_name: Joxan
full_name: Jaffar, Joxan
last_name: Jaffar
citation:
ama: 'Trinh M, Chu DH, Jaffar J. Model counting for recursively-defined strings.
In: Majumdar R, Kunčak V, eds. Vol 10427. Springer; 2017:399-418. doi:10.1007/978-3-319-63390-9_21'
apa: 'Trinh, M., Chu, D. H., & Jaffar, J. (2017). Model counting for recursively-defined
strings. In R. Majumdar & V. Kunčak (Eds.) (Vol. 10427, pp. 399–418). Presented
at the CAV: Computer Aided Verification, Heidelberg, Germany: Springer. https://doi.org/10.1007/978-3-319-63390-9_21'
chicago: Trinh, Minh, Duc Hiep Chu, and Joxan Jaffar. “Model Counting for Recursively-Defined
Strings.” edited by Rupak Majumdar and Viktor Kunčak, 10427:399–418. Springer,
2017. https://doi.org/10.1007/978-3-319-63390-9_21.
ieee: 'M. Trinh, D. H. Chu, and J. Jaffar, “Model counting for recursively-defined
strings,” presented at the CAV: Computer Aided Verification, Heidelberg, Germany,
2017, vol. 10427, pp. 399–418.'
ista: 'Trinh M, Chu DH, Jaffar J. 2017. Model counting for recursively-defined strings.
CAV: Computer Aided Verification, LNCS, vol. 10427, 399–418.'
mla: Trinh, Minh, et al. Model Counting for Recursively-Defined Strings.
Edited by Rupak Majumdar and Viktor Kunčak, vol. 10427, Springer, 2017, pp. 399–418,
doi:10.1007/978-3-319-63390-9_21.
short: M. Trinh, D.H. Chu, J. Jaffar, in:, R. Majumdar, V. Kunčak (Eds.), Springer,
2017, pp. 399–418.
conference:
end_date: 2017-07-28
location: Heidelberg, Germany
name: 'CAV: Computer Aided Verification'
start_date: 2017-07-24
date_created: 2018-12-11T11:49:26Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2026-04-16T09:58:05Z
day: '01'
department:
- _id: ToHe
doi: 10.1007/978-3-319-63390-9_21
editor:
- first_name: Rupak
full_name: Majumdar, Rupak
last_name: Majumdar
- first_name: Viktor
full_name: Kunčak, Viktor
last_name: Kunčak
external_id:
isi:
- '000431900900021'
intvolume: ' 10427'
isi: 1
language:
- iso: eng
month: '01'
oa_version: None
page: 399 - 418
project:
- _id: 25F5A88A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Moderne Concurrency Paradigms
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: Formal methods for the design and analysis of complex systems
publication_identifier:
issn:
- 0302-9743
publication_status: published
publisher: Springer
publist_id: '6443'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Model counting for recursively-defined strings
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 10427
year: '2017'
...
---
_id: '681'
abstract:
- lang: eng
text: Two-player games on graphs provide the theoretical framework for many important
problems such as reactive synthesis. While the traditional study of two-player
zero-sum games has been extended to multi-player games with several notions of
equilibria, they are decidable only for perfect-information games, whereas several
applications require imperfect-information. In this paper we propose a new notion
of equilibria, called doomsday equilibria, which is a strategy profile where all
players satisfy their own objective, and if any coalition of players deviates
and violates even one of the players' objective, then the objective of every player
is violated. We present algorithms and complexity results for deciding the existence
of doomsday equilibria for various classes of ω-regular objectives, both for imperfect-information
games, and for perfect-information games. We provide optimal complexity bounds
for imperfect-information games, and in most cases for perfect-information games.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Emmanuel
full_name: Filiot, Emmanuel
last_name: Filiot
- first_name: Jean
full_name: Raskin, Jean
last_name: Raskin
citation:
ama: Chatterjee K, Doyen L, Filiot E, Raskin J. Doomsday equilibria for omega-regular
games. Information and Computation. 2017;254:296-315. doi:10.1016/j.ic.2016.10.012
apa: Chatterjee, K., Doyen, L., Filiot, E., & Raskin, J. (2017). Doomsday equilibria
for omega-regular games. Information and Computation. Elsevier. https://doi.org/10.1016/j.ic.2016.10.012
chicago: Chatterjee, Krishnendu, Laurent Doyen, Emmanuel Filiot, and Jean Raskin.
“Doomsday Equilibria for Omega-Regular Games.” Information and Computation.
Elsevier, 2017. https://doi.org/10.1016/j.ic.2016.10.012.
ieee: K. Chatterjee, L. Doyen, E. Filiot, and J. Raskin, “Doomsday equilibria for
omega-regular games,” Information and Computation, vol. 254. Elsevier,
pp. 296–315, 2017.
ista: Chatterjee K, Doyen L, Filiot E, Raskin J. 2017. Doomsday equilibria for omega-regular
games. Information and Computation. 254, 296–315.
mla: Chatterjee, Krishnendu, et al. “Doomsday Equilibria for Omega-Regular Games.”
Information and Computation, vol. 254, Elsevier, 2017, pp. 296–315, doi:10.1016/j.ic.2016.10.012.
short: K. Chatterjee, L. Doyen, E. Filiot, J. Raskin, Information and Computation
254 (2017) 296–315.
corr_author: '1'
date_created: 2018-12-11T11:47:53Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2026-04-16T10:00:03Z
day: '01'
department:
- _id: KrCh
doi: 10.1016/j.ic.2016.10.012
ec_funded: 1
external_id:
arxiv:
- '1311.3238'
isi:
- '000402025600008'
intvolume: ' 254'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1311.3238
month: '06'
oa: 1
oa_version: Submitted Version
page: 296 - 315
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Information and Computation
publication_identifier:
issn:
- 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '7036'
quality_controlled: '1'
related_material:
record:
- id: '10885'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Doomsday equilibria for omega-regular games
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 254
year: '2017'
...
---
_id: '650'
abstract:
- lang: eng
text: 'In this work we present a short and unified proof for the Strong and Weak
Regularity Lemma, based on the cryptographic tech-nique called low-complexity
approximations. In short, both problems reduce to a task of finding constructively
an approximation for a certain target function under a class of distinguishers
(test functions), where dis-tinguishers are combinations of simple rectangle-indicators.
In our case these approximations can be learned by a simple iterative procedure,
which yields a unified and simple proof, achieving for any graph with density
d and any approximation parameter the partition size. The novelty in our proof
is: (a) a simple approach which yields both strong and weaker variant, and (b)
improvements when d = o(1). At an abstract level, our proof can be seen a refinement
and simplification of the “analytic” proof given by Lovasz and Szegedy.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Maciej
full_name: Skórski, Maciej
id: EC09FA6A-02D0-11E9-8223-86B7C91467DD
last_name: Skórski
citation:
ama: 'Skórski M. A cryptographic view of regularity lemmas: Simpler unified proofs
and refined bounds. In: Jäger G, Steila S, eds. Vol 10185. Springer; 2017:586-599.
doi:10.1007/978-3-319-55911-7_42'
apa: 'Skórski, M. (2017). A cryptographic view of regularity lemmas: Simpler unified
proofs and refined bounds. In G. Jäger & S. Steila (Eds.) (Vol. 10185, pp.
586–599). Presented at the TAMC: Theory and Applications of Models of Computation,
Bern, Switzerland: Springer. https://doi.org/10.1007/978-3-319-55911-7_42'
chicago: 'Skórski, Maciej. “A Cryptographic View of Regularity Lemmas: Simpler Unified
Proofs and Refined Bounds.” edited by Gerhard Jäger and Silvia Steila, 10185:586–99.
Springer, 2017. https://doi.org/10.1007/978-3-319-55911-7_42.'
ieee: 'M. Skórski, “A cryptographic view of regularity lemmas: Simpler unified proofs
and refined bounds,” presented at the TAMC: Theory and Applications of Models
of Computation, Bern, Switzerland, 2017, vol. 10185, pp. 586–599.'
ista: 'Skórski M. 2017. A cryptographic view of regularity lemmas: Simpler unified
proofs and refined bounds. TAMC: Theory and Applications of Models of Computation,
LNCS, vol. 10185, 586–599.'
mla: 'Skórski, Maciej. A Cryptographic View of Regularity Lemmas: Simpler Unified
Proofs and Refined Bounds. Edited by Gerhard Jäger and Silvia Steila, vol.
10185, Springer, 2017, pp. 586–99, doi:10.1007/978-3-319-55911-7_42.'
short: M. Skórski, in:, G. Jäger, S. Steila (Eds.), Springer, 2017, pp. 586–599.
conference:
end_date: 2017-04-22
location: Bern, Switzerland
name: 'TAMC: Theory and Applications of Models of Computation'
start_date: 2017-04-20
corr_author: '1'
date_created: 2018-12-11T11:47:42Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2026-04-16T09:59:38Z
day: '01'
department:
- _id: KrPi
doi: 10.1007/978-3-319-55911-7_42
editor:
- first_name: Gerhard
full_name: Jäger, Gerhard
last_name: Jäger
- first_name: Silvia
full_name: Steila, Silvia
last_name: Steila
external_id:
isi:
- '000425175500042'
intvolume: ' 10185'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2016/965.pdf
month: '01'
oa: 1
oa_version: Submitted Version
page: 586 - 599
publication_identifier:
issn:
- 0302-9743
publication_status: published
publisher: Springer
publist_id: '7119'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A cryptographic view of regularity lemmas: Simpler unified proofs and refined
bounds'
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 10185
year: '2017'
...
---
_id: '714'
abstract:
- lang: eng
text: Background HIV-1 infection and drug abuse are frequently co-morbid and their
association greatly increases the severity of HIV-1-induced neuropathology. While
nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little
is known about how HIV-1 infection affects NAcc. Methods We used calcium and voltage
imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat)
on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates
intracellular Ca2+ homeostasis of NAcc neurons. Results We provide evidence that
Tat triggers a Ca2+ signaling cascade in NAcc medium spiny neurons (MSN) expressing
D1-like dopamine receptors leading to neuronal depolarization. Firstly, Tat induced
inositol 1,4,5-trisphsophate (IP3) receptor-mediated Ca2+ release from endoplasmic
reticulum, followed by Ca2+ and Na+ influx via transient receptor potential canonical
channels. The influx of cations depolarizes the membrane promoting additional
Ca2+ entry through voltage-gated P/Q-type Ca2+ channels and opening of tetrodotoxin-sensitive
Na+ channels. By activating this mechanism, Tat elicits a feed-forward depolarization
increasing the excitability of D1-phosphatidylinositol-linked NAcc MSN. We previously
found that cocaine targets NAcc neurons directly (independent of the inhibition
of dopamine transporter) only when IP3-generating mechanisms are concomitantly
initiated. When tested here, cocaine produced a dose-dependent potentiation of
the effect of Tat on cytosolic Ca2+. Conclusion We describe for the first time
a HIV-1 Tat-triggered Ca2+ signaling in MSN of NAcc involving TRPC and depolarization
and a potentiation of the effect of Tat by cocaine, which may be relevant for
the reward axis in cocaine-abusing HIV-1-positive patients.
acknowledgement: This work was supported by the National Institutes of Health grants
DA035926 (to MEA), and P30DA013429 (to EMU).
article_processing_charge: No
article_type: original
author:
- first_name: Gabriela
full_name: Brailoiu, Gabriela
last_name: Brailoiu
- first_name: Elena
full_name: Deliu, Elena
id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
last_name: Deliu
orcid: 0000-0002-7370-5293
- first_name: Jeffrey
full_name: Barr, Jeffrey
last_name: Barr
- first_name: Linda
full_name: Console Bram, Linda
last_name: Console Bram
- first_name: Alexandra
full_name: Ciuciu, Alexandra
last_name: Ciuciu
- first_name: Mary
full_name: Abood, Mary
last_name: Abood
- first_name: Ellen
full_name: Unterwald, Ellen
last_name: Unterwald
- first_name: Eugen
full_name: Brǎiloiu, Eugen
last_name: Brǎiloiu
citation:
ama: Brailoiu G, Deliu E, Barr J, et al. HIV Tat excites D1 receptor-like expressing
neurons from rat nucleus accumbens. Drug and Alcohol Dependence. 2017;178:7-14.
doi:10.1016/j.drugalcdep.2017.04.015
apa: Brailoiu, G., Deliu, E., Barr, J., Console Bram, L., Ciuciu, A., Abood, M.,
… Brǎiloiu, E. (2017). HIV Tat excites D1 receptor-like expressing neurons from
rat nucleus accumbens. Drug and Alcohol Dependence. Elsevier. https://doi.org/10.1016/j.drugalcdep.2017.04.015
chicago: Brailoiu, Gabriela, Elena Deliu, Jeffrey Barr, Linda Console Bram, Alexandra
Ciuciu, Mary Abood, Ellen Unterwald, and Eugen Brǎiloiu. “HIV Tat Excites D1 Receptor-like
Expressing Neurons from Rat Nucleus Accumbens.” Drug and Alcohol Dependence.
Elsevier, 2017. https://doi.org/10.1016/j.drugalcdep.2017.04.015.
ieee: G. Brailoiu et al., “HIV Tat excites D1 receptor-like expressing neurons
from rat nucleus accumbens,” Drug and Alcohol Dependence, vol. 178. Elsevier,
pp. 7–14, 2017.
ista: Brailoiu G, Deliu E, Barr J, Console Bram L, Ciuciu A, Abood M, Unterwald
E, Brǎiloiu E. 2017. HIV Tat excites D1 receptor-like expressing neurons from
rat nucleus accumbens. Drug and Alcohol Dependence. 178, 7–14.
mla: Brailoiu, Gabriela, et al. “HIV Tat Excites D1 Receptor-like Expressing Neurons
from Rat Nucleus Accumbens.” Drug and Alcohol Dependence, vol. 178, Elsevier,
2017, pp. 7–14, doi:10.1016/j.drugalcdep.2017.04.015.
short: G. Brailoiu, E. Deliu, J. Barr, L. Console Bram, A. Ciuciu, M. Abood, E.
Unterwald, E. Brǎiloiu, Drug and Alcohol Dependence 178 (2017) 7–14.
date_created: 2018-12-11T11:48:05Z
date_published: 2017-09-01T00:00:00Z
date_updated: 2026-04-16T10:01:59Z
day: '01'
department:
- _id: GaNo
doi: 10.1016/j.drugalcdep.2017.04.015
external_id:
isi:
- '000409152300002'
pmid:
- '28623807'
intvolume: ' 178'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797705
month: '09'
oa: 1
oa_version: Submitted Version
page: 7 - 14
pmid: 1
publication: Drug and Alcohol Dependence
publication_identifier:
issn:
- 0376-8716
publication_status: published
publisher: Elsevier
publist_id: '6967'
quality_controlled: '1'
scopus_import: '1'
status: public
title: HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 178
year: '2017'
...
---
_id: '685'
abstract:
- lang: eng
text: By applying methods and principles from the physical sciences to biological
problems, D'Arcy Thompson's On Growth and Form demonstrated how mathematical reasoning
reveals elegant, simple explanations for seemingly complex processes. This has
had a profound influence on subsequent generations of developmental biologists.
We discuss how this influence can be traced through twentieth century morphologists,
embryologists and theoreticians to current research that explores the molecular
and cellular mechanisms of tissue growth and patterning, including our own studies
of the vertebrate neural tube.
article_processing_charge: No
author:
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Briscoe J, Kicheva A. The physics of development 100 years after D’Arcy Thompson’s
“on growth and form.” Mechanisms of Development. 2017;145:26-31. doi:10.1016/j.mod.2017.03.005
apa: Briscoe, J., & Kicheva, A. (2017). The physics of development 100 years
after D’Arcy Thompson’s “on growth and form.” Mechanisms of Development.
Elsevier. https://doi.org/10.1016/j.mod.2017.03.005
chicago: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years
after D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development.
Elsevier, 2017. https://doi.org/10.1016/j.mod.2017.03.005.
ieee: J. Briscoe and A. Kicheva, “The physics of development 100 years after D’Arcy
Thompson’s ‘on growth and form,’” Mechanisms of Development, vol. 145.
Elsevier, pp. 26–31, 2017.
ista: Briscoe J, Kicheva A. 2017. The physics of development 100 years after D’Arcy
Thompson’s “on growth and form”. Mechanisms of Development. 145, 26–31.
mla: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years after
D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development, vol.
145, Elsevier, 2017, pp. 26–31, doi:10.1016/j.mod.2017.03.005.
short: J. Briscoe, A. Kicheva, Mechanisms of Development 145 (2017) 26–31.
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2026-04-16T10:01:00Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1016/j.mod.2017.03.005
ec_funded: 1
external_id:
isi:
- '000402836800006'
pmid:
- '28366718'
file:
- access_level: open_access
checksum: 727043d2e4199fbef6b3704e6d1ac105
content_type: application/pdf
creator: dernst
date_created: 2019-04-17T07:58:48Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6335'
file_name: 2017_Briscoe_Kicheva_and_DArcy_accepted_version.pdf
file_size: 652313
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 145'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 26 - 31
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Mechanisms of Development
publication_identifier:
issn:
- 0925-4773
publication_status: published
publisher: Elsevier
publist_id: '7025'
pubrep_id: '985'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The physics of development 100 years after D'Arcy Thompson's “on growth and
form”
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 145
year: '2017'
...
---
_id: '747'
abstract:
- lang: eng
text: Bradykinin (BK), a component of the kallikrein-kininogen-kinin system exerts
multiple effects via B1 and B2 receptor activation. In the cardiovascular system,
bradykinin has cardioprotective and vasodilator properties. We investigated the
effect of BK on cardiac-projecting neurons of nucleus ambiguus, a key site for
the parasympathetic cardiac regulation. BK produced a dose-dependent increase
in cytosolic Ca2+ concentration. Pretreatment with HOE140, a B2 receptor antagonist,
but not with R715, a B1 receptor antagonist, abolished the response to BK. A selective
B2 receptor agonist, but not a B1 receptor agonist, elicited an increase in cytosolic
Ca2+ similarly to BK. Inhibition of N-type voltage-gated Ca2+ channels with ω-conotoxin
GVIA had no effect on the Ca2+ signal produced by BK, while pretreatment with
ω-conotoxin MVIIC, a blocker of P/Q-type of Ca2+ channels, significantly diminished
the effect of BK. Pretreatment with xestospongin C and 2-aminoethoxydiphenyl borate,
antagonists of inositol 1,4,5-trisphosphate receptors, abolished the response
to BK. Inhibition of ryanodine receptors reduced the BK-induced Ca2+ increase,
while disruption of lysosomal Ca2+ stores with bafilomycin A1 did not affect the
response. BK produced a dose-dependent depolarization of nucleus ambiguus neurons,
which was prevented by the B2 receptor antagonist. In vivo studies indicate that
microinjection of BK into nucleus ambiguus elicited bradycardia in conscious rats
via B2 receptors. In summary, in cardiac vagal neurons of nucleus ambiguus, BK
activates B2 receptors promoting Ca2+ influx and Ca2+ release from endoplasmic
reticulum, and membrane depolarization; these effects are translated in vivo by
bradycardia.
article_processing_charge: No
article_type: original
author:
- first_name: Eugen
full_name: Brǎiloiu, Eugen
last_name: Brǎiloiu
- first_name: Matthew
full_name: Mcguire, Matthew
last_name: Mcguire
- first_name: Shadaria
full_name: Shuler, Shadaria
last_name: Shuler
- first_name: Elena
full_name: Deliu, Elena
id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
last_name: Deliu
orcid: 0000-0002-7370-5293
- first_name: Jeffrey
full_name: Barr, Jeffrey
last_name: Barr
- first_name: Mary
full_name: Abood, Mary
last_name: Abood
- first_name: Gabriela
full_name: Brailoiu, Gabriela
last_name: Brailoiu
citation:
ama: Brǎiloiu E, Mcguire M, Shuler S, et al. Modulation of cardiac vagal tone by
bradykinin acting on nucleus ambiguus. Neuroscience. 2017;365:23-32. doi:10.1016/j.neuroscience.2017.09.034
apa: Brǎiloiu, E., Mcguire, M., Shuler, S., Deliu, E., Barr, J., Abood, M., &
Brailoiu, G. (2017). Modulation of cardiac vagal tone by bradykinin acting on
nucleus ambiguus. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2017.09.034
chicago: Brǎiloiu, Eugen, Matthew Mcguire, Shadaria Shuler, Elena Deliu, Jeffrey
Barr, Mary Abood, and Gabriela Brailoiu. “Modulation of Cardiac Vagal Tone by
Bradykinin Acting on Nucleus Ambiguus.” Neuroscience. Elsevier, 2017. https://doi.org/10.1016/j.neuroscience.2017.09.034.
ieee: E. Brǎiloiu et al., “Modulation of cardiac vagal tone by bradykinin
acting on nucleus ambiguus,” Neuroscience, vol. 365. Elsevier, pp. 23–32,
2017.
ista: Brǎiloiu E, Mcguire M, Shuler S, Deliu E, Barr J, Abood M, Brailoiu G. 2017.
Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience.
365, 23–32.
mla: Brǎiloiu, Eugen, et al. “Modulation of Cardiac Vagal Tone by Bradykinin Acting
on Nucleus Ambiguus.” Neuroscience, vol. 365, Elsevier, 2017, pp. 23–32,
doi:10.1016/j.neuroscience.2017.09.034.
short: E. Brǎiloiu, M. Mcguire, S. Shuler, E. Deliu, J. Barr, M. Abood, G. Brailoiu,
Neuroscience 365 (2017) 23–32.
date_created: 2018-12-11T11:48:17Z
date_published: 2017-12-04T00:00:00Z
date_updated: 2026-04-16T10:04:53Z
day: '04'
department:
- _id: GaNo
doi: 10.1016/j.neuroscience.2017.09.034
external_id:
isi:
- '000415966200003'
pmid:
- '28951324'
intvolume: ' 365'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798458
month: '12'
oa: 1
oa_version: Submitted Version
page: 23 - 32
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '6911'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 365
year: '2017'
...
---
_id: '989'
abstract:
- lang: eng
text: We present a generalized optimal transport model in which the mass-preserving
constraint for the L2-Wasserstein distance is relaxed by introducing a source
term in the continuity equation. The source term is also incorporated in the path
energy by means of its squared L2-norm in time of a functional with linear growth
in space. This extension of the original transport model enables local density
modulations, which is a desirable feature in applications such as image warping
and blending. A key advantage of the use of a functional with linear growth in
space is that it allows for singular sources and sinks, which can be supported
on points or lines. On a technical level, the L2-norm in time ensures a disintegration
of the source in time, which we use to obtain the well-posedness of the model
and the existence of geodesic paths. The numerical discretization is based on
the proximal splitting approach [18] and selected numerical test cases show the
potential of the proposed approach. Furthermore, the approach is applied to the
warping and blending of textures.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Martin
full_name: Rumpf, Martin
last_name: Rumpf
- first_name: Stefan
full_name: Simon, Stefan
last_name: Simon
citation:
ama: 'Maas J, Rumpf M, Simon S. Transport based image morphing with intensity modulation.
In: Lauze F, Dong Y, Bjorholm Dahl A, eds. Vol 10302. Springer; 2017:563-577.
doi:10.1007/978-3-319-58771-4_45'
apa: 'Maas, J., Rumpf, M., & Simon, S. (2017). Transport based image morphing
with intensity modulation. In F. Lauze, Y. Dong, & A. Bjorholm Dahl (Eds.)
(Vol. 10302, pp. 563–577). Presented at the SSVM: Scale Space and Variational
Methods in Computer Vision, Kolding, Denmark: Springer. https://doi.org/10.1007/978-3-319-58771-4_45'
chicago: Maas, Jan, Martin Rumpf, and Stefan Simon. “Transport Based Image Morphing
with Intensity Modulation.” edited by François Lauze, Yiqiu Dong, and Anders Bjorholm
Dahl, 10302:563–77. Springer, 2017. https://doi.org/10.1007/978-3-319-58771-4_45.
ieee: J. Maas, M. Rumpf, and S. Simon, “Transport based image morphing with intensity
modulation,” presented at the SSVM: Scale Space and Variational Methods in Computer
Vision, Kolding, Denmark, 2017, vol. 10302, pp. 563–577.
ista: Maas J, Rumpf M, Simon S. 2017. Transport based image morphing with intensity
modulation. SSVM: Scale Space and Variational Methods in Computer Vision, LNCS,
vol. 10302, 563–577.
mla: Maas, Jan, et al. Transport Based Image Morphing with Intensity Modulation.
Edited by François Lauze et al., vol. 10302, Springer, 2017, pp. 563–77, doi:10.1007/978-3-319-58771-4_45.
short: J. Maas, M. Rumpf, S. Simon, in:, F. Lauze, Y. Dong, A. Bjorholm Dahl (Eds.),
Springer, 2017, pp. 563–577.
conference:
end_date: 2017-06-08
location: Kolding, Denmark
name: 'SSVM: Scale Space and Variational Methods in Computer Vision'
start_date: 2017-06-04
date_created: 2018-12-11T11:49:34Z
date_published: 2017-05-18T00:00:00Z
date_updated: 2026-04-16T10:05:10Z
day: '18'
department:
- _id: JaMa
doi: 10.1007/978-3-319-58771-4_45
editor:
- first_name: François
full_name: Lauze, François
last_name: Lauze
- first_name: Yiqiu
full_name: Dong, Yiqiu
last_name: Dong
- first_name: Anders
full_name: Bjorholm Dahl, Anders
last_name: Bjorholm Dahl
external_id:
isi:
- '000432210900045'
intvolume: ' 10302'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
page: 563 - 577
publication_identifier:
issn:
- 0302-9743
publication_status: published
publisher: Springer
publist_id: '6410'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transport based image morphing with intensity modulation
type: conference
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 10302
year: '2017'
...
---
_id: '712'
abstract:
- lang: eng
text: 'We establish a weak–strong uniqueness principle for solutions to entropy-dissipating
reaction–diffusion equations: As long as a strong solution to the reaction–diffusion
equation exists, any weak solution and even any renormalized solution must coincide
with this strong solution. Our assumptions on the reaction rates are just the
entropy condition and local Lipschitz continuity; in particular, we do not impose
any growth restrictions on the reaction rates. Therefore, our result applies to
any single reversible reaction with mass-action kinetics as well as to systems
of reversible reactions with mass-action kinetics satisfying the detailed balance
condition. Renormalized solutions are known to exist globally in time for reaction–diffusion
equations with entropy-dissipating reaction rates; in contrast, the global-in-time
existence of weak solutions is in general still an open problem–even for smooth
data–, thereby motivating the study of renormalized solutions. The key ingredient
of our result is a careful adjustment of the usual relative entropy functional,
whose evolution cannot be controlled properly for weak solutions or renormalized
solutions.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: 'Fischer JL. Weak–strong uniqueness of solutions to entropy dissipating reaction–diffusion
equations. Nonlinear Analysis: Theory, Methods and Applications. 2017;159:181-207.
doi:10.1016/j.na.2017.03.001'
apa: 'Fischer, J. L. (2017). Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations. Nonlinear Analysis: Theory, Methods and Applications.
Elsevier. https://doi.org/10.1016/j.na.2017.03.001'
chicago: 'Fischer, Julian L. “Weak–Strong Uniqueness of Solutions to Entropy Dissipating
Reaction–Diffusion Equations.” Nonlinear Analysis: Theory, Methods and Applications.
Elsevier, 2017. https://doi.org/10.1016/j.na.2017.03.001.'
ieee: 'J. L. Fischer, “Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations,” Nonlinear Analysis: Theory, Methods and Applications,
vol. 159. Elsevier, pp. 181–207, 2017.'
ista: 'Fischer JL. 2017. Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations. Nonlinear Analysis: Theory, Methods and Applications.
159, 181–207.'
mla: 'Fischer, Julian L. “Weak–Strong Uniqueness of Solutions to Entropy Dissipating
Reaction–Diffusion Equations.” Nonlinear Analysis: Theory, Methods and Applications,
vol. 159, Elsevier, 2017, pp. 181–207, doi:10.1016/j.na.2017.03.001.'
short: 'J.L. Fischer, Nonlinear Analysis: Theory, Methods and Applications 159 (2017)
181–207.'
corr_author: '1'
date_created: 2018-12-11T11:48:05Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2026-04-16T10:01:49Z
day: '01'
department:
- _id: JuFi
doi: 10.1016/j.na.2017.03.001
external_id:
arxiv:
- '1703.00730'
isi:
- '000404309400009'
intvolume: ' 159'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1703.00730
month: '08'
oa: 1
oa_version: Submitted Version
page: 181 - 207
publication: 'Nonlinear Analysis: Theory, Methods and Applications'
publication_identifier:
issn:
- 0362-546X
publication_status: published
publisher: Elsevier
publist_id: '6975'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Weak–strong uniqueness of solutions to entropy dissipating reaction–diffusion
equations
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 159
year: '2017'
...
---
_id: '730'
abstract:
- lang: eng
text: Neural responses are highly structured, with population activity restricted
to a small subset of the astronomical range of possible activity patterns. Characterizing
these statistical regularities is important for understanding circuit computation,
but challenging in practice. Here we review recent approaches based on the maximum
entropy principle used for quantifying collective behavior in neural activity.
We highlight recent models that capture population-level statistics of neural
data, yielding insights into the organization of the neural code and its biological
substrate. Furthermore, the MaxEnt framework provides a general recipe for constructing
surrogate ensembles that preserve aspects of the data, but are otherwise maximally
unstructured. This idea can be used to generate a hierarchy of controls against
which rigorous statistical tests are possible.
article_processing_charge: No
author:
- first_name: Cristina
full_name: Savin, Cristina
id: 3933349E-F248-11E8-B48F-1D18A9856A87
last_name: Savin
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
citation:
ama: Savin C, Tkačik G. Maximum entropy models as a tool for building precise neural
controls. Current Opinion in Neurobiology. 2017;46:120-126. doi:10.1016/j.conb.2017.08.001
apa: Savin, C., & Tkačik, G. (2017). Maximum entropy models as a tool for building
precise neural controls. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2017.08.001
chicago: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for
Building Precise Neural Controls.” Current Opinion in Neurobiology. Elsevier,
2017. https://doi.org/10.1016/j.conb.2017.08.001.
ieee: C. Savin and G. Tkačik, “Maximum entropy models as a tool for building precise
neural controls,” Current Opinion in Neurobiology, vol. 46. Elsevier, pp.
120–126, 2017.
ista: Savin C, Tkačik G. 2017. Maximum entropy models as a tool for building precise
neural controls. Current Opinion in Neurobiology. 46, 120–126.
mla: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for Building
Precise Neural Controls.” Current Opinion in Neurobiology, vol. 46, Elsevier,
2017, pp. 120–26, doi:10.1016/j.conb.2017.08.001.
short: C. Savin, G. Tkačik, Current Opinion in Neurobiology 46 (2017) 120–126.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2026-04-16T10:04:15Z
day: '01'
department:
- _id: GaTk
doi: 10.1016/j.conb.2017.08.001
ec_funded: 1
external_id:
isi:
- '000416196400016'
intvolume: ' 46'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 120 - 126
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '6943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maximum entropy models as a tool for building precise neural controls
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 46
year: '2017'
...
---
_id: '686'
abstract:
- lang: eng
text: Tissues are thought to behave like fluids with a given surface tension. Differences
in tissue surface tension (TST) have been proposed to trigger cell sorting and
tissue envelopment. D'Arcy Thompson in his seminal book ‘On Growth and Form’ has
introduced this concept of differential TST as a key physical mechanism dictating
tissue formation and organization within the developing organism. Over the past
century, many studies have picked up the concept of differential TST and analyzed
the role and cell biological basis of TST in development, underlining the importance
and influence of this concept in developmental biology.
article_processing_charge: No
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Heisenberg C-PJ. D’Arcy Thompson’s ‘on growth and form’: From soap bubbles
to tissue self organization. Mechanisms of Development. 2017;145:32-37.
doi:10.1016/j.mod.2017.03.006'
apa: 'Heisenberg, C.-P. J. (2017). D’Arcy Thompson’s ‘on growth and form’: From
soap bubbles to tissue self organization. Mechanisms of Development. Elsevier.
https://doi.org/10.1016/j.mod.2017.03.006'
chicago: 'Heisenberg, Carl-Philipp J. “D’Arcy Thompson’s ‘on Growth and Form’: From
Soap Bubbles to Tissue Self Organization.” Mechanisms of Development. Elsevier,
2017. https://doi.org/10.1016/j.mod.2017.03.006.'
ieee: 'C.-P. J. Heisenberg, “D’Arcy Thompson’s ‘on growth and form’: From soap bubbles
to tissue self organization,” Mechanisms of Development, vol. 145. Elsevier,
pp. 32–37, 2017.'
ista: 'Heisenberg C-PJ. 2017. D’Arcy Thompson’s ‘on growth and form’: From soap
bubbles to tissue self organization. Mechanisms of Development. 145, 32–37.'
mla: 'Heisenberg, Carl-Philipp J. “D’Arcy Thompson’s ‘on Growth and Form’: From
Soap Bubbles to Tissue Self Organization.” Mechanisms of Development, vol.
145, Elsevier, 2017, pp. 32–37, doi:10.1016/j.mod.2017.03.006.'
short: C.-P.J. Heisenberg, Mechanisms of Development 145 (2017) 32–37.
corr_author: '1'
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2026-04-16T10:01:32Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.mod.2017.03.006
external_id:
isi:
- '000402836800007'
intvolume: ' 145'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
page: 32 - 37
publication: Mechanisms of Development
publication_identifier:
issn:
- 0925-4773
publication_status: published
publisher: Elsevier
publist_id: '7024'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'D''Arcy Thompson''s ‘on growth and form’: From soap bubbles to tissue self
organization'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 145
year: '2017'
...