---
_id: '1153'
abstract:
- lang: eng
  text: Differential cell growth enables flexible organ bending in the presence of
    environmental signals such as light or gravity. A prominent example of the developmental
    processes based on differential cell growth is the formation of the apical hook
    that protects the fragile shoot apical meristem when it breaks through the soil
    during germination. Here, we combined in silico and in vivo approaches to identify
    a minimal mechanism producing auxin gradient-guided differential growth during
    the establishment of the apical hook in the model plant Arabidopsis thaliana.
    Computer simulation models based on experimental data demonstrate that asymmetric
    expression of the PIN-FORMED auxin efflux carrier at the concave (inner) versus
    convex (outer) side of the hook suffices to establish an auxin maximum in the
    epidermis at the concave side of the apical hook. Furthermore, we propose a mechanism
    that translates this maximum into differential growth, and thus curvature, of
    the apical hook. Through a combination of experimental and in silico computational
    approaches, we have identified the individual contributions of differential cell
    elongation and proliferation to defining the apical hook and reveal the role of
    auxin-ethylene crosstalk in balancing these two processes. © 2016 American Society
    of Plant Biologists. All rights reserved.
acknowledgement: "We thank Martine De Cock and Annick Bleys for help in preparing
  the manuscript, Daniel Van Damme for sharing material and stimulating discussion,
  and Rudiger Simon for support during revision of the manuscript.\r\nThis work was
  supported by grants from the European Research Council (StartingIndependentResearchGrantERC-2007-Stg-207362-HCPO)and
  the Czech Science Foundation (GACR CZ.1.07/2.3.00/20.0043) to E.B.\r\nand Natural
  Sciences and Engineering Research Council of Canada Discovery Grant 2014-05325 to
  P.P. K.W. acknowledges funding from a Human Frontier Science Program Long-Term Fellowship
  (LT-000209-2014)."
article_processing_charge: No
author:
- first_name: Petra
  full_name: Žádníková, Petra
  last_name: Žádníková
- first_name: Krzysztof T
  full_name: Wabnik, Krzysztof T
  id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
  last_name: Wabnik
  orcid: 0000-0001-7263-0560
- first_name: Anas
  full_name: Abuzeineh, Anas
  last_name: Abuzeineh
- first_name: Marçal
  full_name: Gallemí, Marçal
  last_name: Gallemí
- first_name: Dominique
  full_name: Van Der Straeten, Dominique
  last_name: Van Der Straeten
- first_name: Richard
  full_name: Smith, Richard
  last_name: Smith
- first_name: Dirk
  full_name: Inze, Dirk
  last_name: Inze
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Przemysław
  full_name: Prusinkiewicz, Przemysław
  last_name: Prusinkiewicz
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Žádníková P, Wabnik KT, Abuzeineh A, et al. A model of differential growth
    guided apical hook formation in plants. <i>Plant Cell</i>. 2016;28(10):2464-2477.
    doi:<a href="https://doi.org/10.1105/tpc.15.00569">10.1105/tpc.15.00569</a>
  apa: Žádníková, P., Wabnik, K. T., Abuzeineh, A., Gallemí, M., Van Der Straeten,
    D., Smith, R., … Benková, E. (2016). A model of differential growth guided apical
    hook formation in plants. <i>Plant Cell</i>. American Society of Plant Biologists.
    <a href="https://doi.org/10.1105/tpc.15.00569">https://doi.org/10.1105/tpc.15.00569</a>
  chicago: Žádníková, Petra, Krzysztof T Wabnik, Anas Abuzeineh, Marçal Gallemí, Dominique
    Van Der Straeten, Richard Smith, Dirk Inze, Jiří Friml, Przemysław Prusinkiewicz,
    and Eva Benková. “A Model of Differential Growth Guided Apical Hook Formation
    in Plants.” <i>Plant Cell</i>. American Society of Plant Biologists, 2016. <a
    href="https://doi.org/10.1105/tpc.15.00569">https://doi.org/10.1105/tpc.15.00569</a>.
  ieee: P. Žádníková <i>et al.</i>, “A model of differential growth guided apical
    hook formation in plants,” <i>Plant Cell</i>, vol. 28, no. 10. American Society
    of Plant Biologists, pp. 2464–2477, 2016.
  ista: Žádníková P, Wabnik KT, Abuzeineh A, Gallemí M, Van Der Straeten D, Smith
    R, Inze D, Friml J, Prusinkiewicz P, Benková E. 2016. A model of differential
    growth guided apical hook formation in plants. Plant Cell. 28(10), 2464–2477.
  mla: Žádníková, Petra, et al. “A Model of Differential Growth Guided Apical Hook
    Formation in Plants.” <i>Plant Cell</i>, vol. 28, no. 10, American Society of
    Plant Biologists, 2016, pp. 2464–77, doi:<a href="https://doi.org/10.1105/tpc.15.00569">10.1105/tpc.15.00569</a>.
  short: P. Žádníková, K.T. Wabnik, A. Abuzeineh, M. Gallemí, D. Van Der Straeten,
    R. Smith, D. Inze, J. Friml, P. Prusinkiewicz, E. Benková, Plant Cell 28 (2016)
    2464–2477.
corr_author: '1'
date_created: 2018-12-11T11:50:26Z
date_published: 2016-10-01T00:00:00Z
date_updated: 2025-09-22T09:56:45Z
day: '01'
department:
- _id: EvBe
- _id: JiFr
doi: 10.1105/tpc.15.00569
ec_funded: 1
external_id:
  isi:
  - '000390135400013'
intvolume: '        28'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134968/
month: '10'
oa: 1
oa_version: Submitted Version
page: 2464 - 2477
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Plant Cell
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '6205'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A model of differential growth guided apical hook formation in plants
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 28
year: '2016'
...
---
_id: '1154'
abstract:
- lang: eng
  text: "Cellular locomotion is a central hallmark of eukaryotic life. It is governed
    by cell-extrinsic molecular factors, which can either emerge in the soluble phase
    or as immobilized, often adhesive ligands. To encode for direction, every cue
    must be present as a spatial or temporal gradient. Here, we developed a microfluidic
    chamber that allows measurement of cell migration in combined response to surface
    immobilized and soluble molecular gradients. As a proof of principle we study
    the response of dendritic cells to their major guidance cues, chemokines. The
    majority of data on chemokine gradient sensing is based on in vitro studies employing
    soluble gradients. Despite evidence suggesting that in vivo chemokines are often
    immobilized to sugar residues, limited information is available how cells respond
    to immobilized chemokines. We tracked migration of dendritic cells towards immobilized
    gradients of the chemokine CCL21 and varying superimposed soluble gradients of
    CCL19. Differential migratory patterns illustrate the potential of our setup to
    quantitatively study the competitive response to both types of gradients. Beyond
    chemokines our approach is broadly applicable to alternative systems of chemo-
    and haptotaxis such as cells migrating along gradients of adhesion receptor ligands
    vs. any soluble cue. \r\n"
acknowledgement: 'This work was supported by the Swiss National Science Foundation
  (Ambizione fellowship; PZ00P3-154733 to M.M.), the Swiss Multiple Sclerosis Society
  (research support to M.M.), a fellowship from the Boehringer Ingelheim Fonds (BIF)
  to J.S., the European Research Council (grant ERC GA 281556) and a START award from
  the Austrian Science Foundation (FWF) to M.S. #BioimagingFacility'
article_number: '36440'
article_processing_charge: No
author:
- first_name: Jan
  full_name: Schwarz, Jan
  id: 346C1EC6-F248-11E8-B48F-1D18A9856A87
  last_name: Schwarz
- first_name: Veronika
  full_name: Bierbaum, Veronika
  id: 3FD04378-F248-11E8-B48F-1D18A9856A87
  last_name: Bierbaum
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Tino
  full_name: Frank, Tino
  last_name: Frank
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Savaş
  full_name: Tay, Savaş
  last_name: Tay
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Matthias
  full_name: Mehling, Matthias
  id: 3C23B994-F248-11E8-B48F-1D18A9856A87
  last_name: Mehling
  orcid: 0000-0001-8599-1226
citation:
  ama: Schwarz J, Bierbaum V, Merrin J, et al. A microfluidic device for measuring
    cell migration towards substrate bound and soluble chemokine gradients. <i>Scientific
    Reports</i>. 2016;6. doi:<a href="https://doi.org/10.1038/srep36440">10.1038/srep36440</a>
  apa: Schwarz, J., Bierbaum, V., Merrin, J., Frank, T., Hauschild, R., Bollenbach,
    M. T., … Mehling, M. (2016). A microfluidic device for measuring cell migration
    towards substrate bound and soluble chemokine gradients. <i>Scientific Reports</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/srep36440">https://doi.org/10.1038/srep36440</a>
  chicago: Schwarz, Jan, Veronika Bierbaum, Jack Merrin, Tino Frank, Robert Hauschild,
    Mark Tobias Bollenbach, Savaş Tay, Michael K Sixt, and Matthias Mehling. “A Microfluidic
    Device for Measuring Cell Migration towards Substrate Bound and Soluble Chemokine
    Gradients.” <i>Scientific Reports</i>. Nature Publishing Group, 2016. <a href="https://doi.org/10.1038/srep36440">https://doi.org/10.1038/srep36440</a>.
  ieee: J. Schwarz <i>et al.</i>, “A microfluidic device for measuring cell migration
    towards substrate bound and soluble chemokine gradients,” <i>Scientific Reports</i>,
    vol. 6. Nature Publishing Group, 2016.
  ista: Schwarz J, Bierbaum V, Merrin J, Frank T, Hauschild R, Bollenbach MT, Tay
    S, Sixt MK, Mehling M. 2016. A microfluidic device for measuring cell migration
    towards substrate bound and soluble chemokine gradients. Scientific Reports. 6,
    36440.
  mla: Schwarz, Jan, et al. “A Microfluidic Device for Measuring Cell Migration towards
    Substrate Bound and Soluble Chemokine Gradients.” <i>Scientific Reports</i>, vol.
    6, 36440, Nature Publishing Group, 2016, doi:<a href="https://doi.org/10.1038/srep36440">10.1038/srep36440</a>.
  short: J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach,
    S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).
date_created: 2018-12-11T11:50:27Z
date_published: 2016-11-07T00:00:00Z
date_updated: 2025-09-22T09:56:13Z
day: '07'
ddc:
- '579'
department:
- _id: MiSi
- _id: NanoFab
- _id: Bio
- _id: ToBo
doi: 10.1038/srep36440
ec_funded: 1
external_id:
  isi:
  - '000387118300001'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:32Z
  date_updated: 2018-12-12T10:09:32Z
  file_id: '4756'
  file_name: IST-2017-744-v1+1_srep36440.pdf
  file_size: 2353456
  relation: main_file
file_date_updated: 2018-12-12T10:09:32Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Y 564-B12
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6204'
pubrep_id: '744'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A microfluidic device for measuring cell migration towards substrate bound
  and soluble chemokine gradients
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1157'
abstract:
- lang: eng
  text: We consider sample covariance matrices of the form Q = ( σ1/2X)(σ1/2X)∗, where
    the sample X is an M ×N random matrix whose entries are real independent random
    variables with variance 1/N and whereσ is an M × M positive-definite deterministic
    matrix. We analyze the asymptotic fluctuations of the largest rescaled eigenvalue
    of Q when both M and N tend to infinity with N/M →d ϵ (0,∞). For a large class
    of populations σ in the sub-critical regime, we show that the distribution of
    the largest rescaled eigenvalue of Q is given by the type-1 Tracy-Widom distribution
    under the additional assumptions that (1) either the entries of X are i.i.d. Gaussians
    or (2) that σ is diagonal and that the entries of X have a sub-exponential decay.
acknowledgement: "We thank Horng-Tzer Yau for numerous discussions and remarks. We
  are grateful to Ben Adlam, Jinho Baik, Zhigang Bao, Paul Bourgade, László Erd ̋os,
  Iain Johnstone and Antti Knowles for comments. We are also grate-\r\nful to the
  anonymous referee for carefully reading our manuscript and suggesting several improvements."
article_processing_charge: No
arxiv: 1
author:
- first_name: Ji
  full_name: Lee, Ji
  last_name: Lee
- first_name: Kevin
  full_name: Schnelli, Kevin
  id: 434AD0AE-F248-11E8-B48F-1D18A9856A87
  last_name: Schnelli
  orcid: 0000-0003-0954-3231
citation:
  ama: Lee J, Schnelli K. Tracy-widom distribution for the largest eigenvalue of real
    sample covariance matrices with general population. <i>Annals of Applied Probability</i>.
    2016;26(6):3786-3839. doi:<a href="https://doi.org/10.1214/16-AAP1193">10.1214/16-AAP1193</a>
  apa: Lee, J., &#38; Schnelli, K. (2016). Tracy-widom distribution for the largest
    eigenvalue of real sample covariance matrices with general population. <i>Annals
    of Applied Probability</i>. Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/16-AAP1193">https://doi.org/10.1214/16-AAP1193</a>
  chicago: Lee, Ji, and Kevin Schnelli. “Tracy-Widom Distribution for the Largest
    Eigenvalue of Real Sample Covariance Matrices with General Population.” <i>Annals
    of Applied Probability</i>. Institute of Mathematical Statistics, 2016. <a href="https://doi.org/10.1214/16-AAP1193">https://doi.org/10.1214/16-AAP1193</a>.
  ieee: J. Lee and K. Schnelli, “Tracy-widom distribution for the largest eigenvalue
    of real sample covariance matrices with general population,” <i>Annals of Applied
    Probability</i>, vol. 26, no. 6. Institute of Mathematical Statistics, pp. 3786–3839,
    2016.
  ista: Lee J, Schnelli K. 2016. Tracy-widom distribution for the largest eigenvalue
    of real sample covariance matrices with general population. Annals of Applied
    Probability. 26(6), 3786–3839.
  mla: Lee, Ji, and Kevin Schnelli. “Tracy-Widom Distribution for the Largest Eigenvalue
    of Real Sample Covariance Matrices with General Population.” <i>Annals of Applied
    Probability</i>, vol. 26, no. 6, Institute of Mathematical Statistics, 2016, pp.
    3786–839, doi:<a href="https://doi.org/10.1214/16-AAP1193">10.1214/16-AAP1193</a>.
  short: J. Lee, K. Schnelli, Annals of Applied Probability 26 (2016) 3786–3839.
date_created: 2018-12-11T11:50:27Z
date_published: 2016-12-15T00:00:00Z
date_updated: 2025-09-22T09:55:43Z
day: '15'
department:
- _id: LaEr
doi: 10.1214/16-AAP1193
ec_funded: 1
external_id:
  arxiv:
  - '1409.4979'
  isi:
  - '000391240100016'
intvolume: '        26'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1409.4979
month: '12'
oa: 1
oa_version: Preprint
page: 3786 - 3839
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
publication: Annals of Applied Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '6201'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tracy-widom distribution for the largest eigenvalue of real sample covariance
  matrices with general population
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 26
year: '2016'
...
---
_id: '1158'
abstract:
- lang: eng
  text: Speciation results from the progressive accumulation of mutations that decrease
    the probability of mating between parental populations or reduce the fitness of
    hybrids—the so-called species barriers. The speciation genomic literature, however,
    is mainly a collection of case studies, each with its own approach and specificities,
    such that a global view of the gradual process of evolution from one to two species
    is currently lacking. Of primary importance is the prevalence of gene flow between
    diverging entities, which is central in most species concepts and has been widely
    discussed in recent years. Here, we explore the continuum of speciation thanks
    to a comparative analysis of genomic data from 61 pairs of populations/species
    of animals with variable levels of divergence. Gene flow between diverging gene
    pools is assessed under an approximate Bayesian computation (ABC) framework. We
    show that the intermediate &quot;grey zone&quot; of speciation, in which taxonomy
    is often controversial, spans from 0.5% to 2% of net synonymous divergence, irrespective
    of species life history traits or ecology. Thanks to appropriate modeling of among-locus
    variation in genetic drift and introgression rate, we clarify the status of the
    majority of ambiguous cases and uncover a number of cryptic species. Our analysis
    also reveals the high incidence in animals of semi-isolated species (when some
    but not all loci are affected by barriers to gene flow) and highlights the intrinsic
    difficulty, both statistical and conceptual, of delineating species in the grey
    zone of speciation.
acknowledgement: "European Research Council (ERC) https://erc.europa.eu/ (grant number
  ERC grant 232971). PopPhyl project. The funder had no role in study design, data
  collection and analysis, decision to publish, or preparation of the manuscript.
  French National Research Agency (ANR) http://www.agence-nationale-recherche.fr/en/project-based-funding-to-advance-french-research/
  (grant number ANR-12-BSV7- 0011). HYSEA project.\r\nWe thank Aude Darracq, Vincent
  Castric, Pierre-Alexandre Gagnaire, Xavier Vekemans, and John Welch for insightful
  discussions. The computations were performed at the Vital-IT (http://www.vital-it.ch)
  Center for high-performance computing of the SIB Swiss Institute of Bioinformatics
  and the ISEM computing cluster at the platform Montpellier Bioinformatique et Biodiversité."
article_number: e2000234
article_processing_charge: No
author:
- first_name: Camille
  full_name: Roux, Camille
  last_name: Roux
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Jonathan
  full_name: Romiguier, Jonathan
  last_name: Romiguier
- first_name: Youann
  full_name: Anciaux, Youann
  last_name: Anciaux
- first_name: Nicolas
  full_name: Galtier, Nicolas
  last_name: Galtier
- first_name: Nicolas
  full_name: Bierne, Nicolas
  last_name: Bierne
citation:
  ama: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. Shedding light
    on the grey zone of speciation along a continuum of genomic divergence. <i>PLoS
    Biology</i>. 2016;14(12). doi:<a href="https://doi.org/10.1371/journal.pbio.2000234">10.1371/journal.pbio.2000234</a>
  apa: Roux, C., Fraisse, C., Romiguier, J., Anciaux, Y., Galtier, N., &#38; Bierne,
    N. (2016). Shedding light on the grey zone of speciation along a continuum of
    genomic divergence. <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.2000234">https://doi.org/10.1371/journal.pbio.2000234</a>
  chicago: Roux, Camille, Christelle Fraisse, Jonathan Romiguier, Youann Anciaux,
    Nicolas Galtier, and Nicolas Bierne. “Shedding Light on the Grey Zone of Speciation
    along a Continuum of Genomic Divergence.” <i>PLoS Biology</i>. Public Library
    of Science, 2016. <a href="https://doi.org/10.1371/journal.pbio.2000234">https://doi.org/10.1371/journal.pbio.2000234</a>.
  ieee: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, and N. Bierne,
    “Shedding light on the grey zone of speciation along a continuum of genomic divergence,”
    <i>PLoS Biology</i>, vol. 14, no. 12. Public Library of Science, 2016.
  ista: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. 2016. Shedding
    light on the grey zone of speciation along a continuum of genomic divergence.
    PLoS Biology. 14(12), e2000234.
  mla: Roux, Camille, et al. “Shedding Light on the Grey Zone of Speciation along
    a Continuum of Genomic Divergence.” <i>PLoS Biology</i>, vol. 14, no. 12, e2000234,
    Public Library of Science, 2016, doi:<a href="https://doi.org/10.1371/journal.pbio.2000234">10.1371/journal.pbio.2000234</a>.
  short: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, N. Bierne, PLoS
    Biology 14 (2016).
date_created: 2018-12-11T11:50:28Z
date_published: 2016-12-27T00:00:00Z
date_updated: 2025-09-22T09:55:10Z
day: '27'
ddc:
- '576'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1371/journal.pbio.2000234
external_id:
  isi:
  - '000392120100008'
file:
- access_level: open_access
  checksum: 2bab63b068a9840efd532b9ae583f9bb
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:42Z
  date_updated: 2020-07-14T12:44:36Z
  file_id: '5164'
  file_name: IST-2017-742-v1+1_journal.pbio.2000234.pdf
  file_size: 2494348
  relation: main_file
file_date_updated: 2020-07-14T12:44:36Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6200'
pubrep_id: '742'
quality_controlled: '1'
related_material:
  record:
  - id: '9862'
    relation: research_data
    status: public
  - id: '9863'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Shedding light on the grey zone of speciation along a continuum of genomic
  divergence
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14
year: '2016'
...
---
_id: '1164'
abstract:
- lang: eng
  text: 'A drawing of a graph G is radial if the vertices of G are placed on concentric
    circles C1, … , Ck with common center c, and edges are drawn radially: every edge
    intersects every circle centered at c at most once. G is radial planar if it has
    a radial embedding, that is, a crossing-free radial drawing. If the vertices of
    G are ordered or partitioned into ordered levels (as they are for leveled graphs),
    we require that the assignment of vertices to circles corresponds to the given
    ordering or leveling. A pair of edges e and f in a graph is independent if e and
    f do not share a vertex. We show that a graph G is radial planar if G has a radial
    drawing in which every two independent edges cross an even number of times; the
    radial embedding has the same leveling as the radial drawing. In other words,
    we establish the strong Hanani-Tutte theorem for radial planarity. This characterization
    yields a very simple algorithm for radial planarity testing.'
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Michael
  full_name: Pelsmajer, Michael
  last_name: Pelsmajer
- first_name: Marcus
  full_name: Schaefer, Marcus
  last_name: Schaefer
citation:
  ama: 'Fulek R, Pelsmajer M, Schaefer M. Hanani-Tutte for radial planarity II. In:
    Vol 9801. Springer; 2016:468-481. doi:<a href="https://doi.org/10.1007/978-3-319-50106-2_36">10.1007/978-3-319-50106-2_36</a>'
  apa: 'Fulek, R., Pelsmajer, M., &#38; Schaefer, M. (2016). Hanani-Tutte for radial
    planarity II (Vol. 9801, pp. 468–481). Presented at the GD: Graph Drawing and
    Network Visualization, Athens, Greece: Springer. <a href="https://doi.org/10.1007/978-3-319-50106-2_36">https://doi.org/10.1007/978-3-319-50106-2_36</a>'
  chicago: Fulek, Radoslav, Michael Pelsmajer, and Marcus Schaefer. “Hanani-Tutte
    for Radial Planarity II,” 9801:468–81. Springer, 2016. <a href="https://doi.org/10.1007/978-3-319-50106-2_36">https://doi.org/10.1007/978-3-319-50106-2_36</a>.
  ieee: 'R. Fulek, M. Pelsmajer, and M. Schaefer, “Hanani-Tutte for radial planarity
    II,” presented at the GD: Graph Drawing and Network Visualization, Athens, Greece,
    2016, vol. 9801, pp. 468–481.'
  ista: 'Fulek R, Pelsmajer M, Schaefer M. 2016. Hanani-Tutte for radial planarity
    II. GD: Graph Drawing and Network Visualization, LNCS, vol. 9801, 468–481.'
  mla: Fulek, Radoslav, et al. <i>Hanani-Tutte for Radial Planarity II</i>. Vol. 9801,
    Springer, 2016, pp. 468–81, doi:<a href="https://doi.org/10.1007/978-3-319-50106-2_36">10.1007/978-3-319-50106-2_36</a>.
  short: R. Fulek, M. Pelsmajer, M. Schaefer, in:, Springer, 2016, pp. 468–481.
conference:
  end_date: 2016-09-21
  location: Athens, Greece
  name: 'GD: Graph Drawing and Network Visualization'
  start_date: 2016-09-19
date_created: 2018-12-11T11:50:29Z
date_published: 2016-12-08T00:00:00Z
date_updated: 2025-09-23T09:13:42Z
day: '08'
department:
- _id: UlWa
doi: 10.1007/978-3-319-50106-2_36
ec_funded: 1
external_id:
  arxiv:
  - '1608.08662'
  isi:
  - '000405478500036'
intvolume: '      9801'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1608.08662
month: '12'
oa: 1
oa_version: Preprint
page: 468 - 481
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Springer
publist_id: '6193'
quality_controlled: '1'
related_material:
  record:
  - id: '1113'
    relation: later_version
    status: public
  - id: '1595'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Hanani-Tutte for radial planarity II
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9801
year: '2016'
...
---
_id: '1165'
abstract:
- lang: eng
  text: We show that c-planarity is solvable in quadratic time for flat clustered
    graphs with three clusters if the combinatorial embedding of the underlying graph
    is fixed. In simpler graph-theoretical terms our result can be viewed as follows.
    Given a graph G with the vertex set partitioned into three parts embedded on a
    2-sphere, our algorithm decides if we can augment G by adding edges without creating
    an edge-crossing so that in the resulting spherical graph the vertices of each
    part induce a connected sub-graph. We proceed by a reduction to the problem of
    testing the existence of a perfect matching in planar bipartite graphs. We formulate
    our result in a slightly more general setting of cyclic clustered graphs, i.e.,
    the simple graph obtained by contracting each cluster, where we disregard loops
    and multi-edges, is a cycle.
acknowledgement: "R. Fulek—The research leading to these results has received funding
  from the People Programme (Marie Curie Actions) of the European Union’s Seventh
  Framework Programme (FP7/2007-2013) under REA grant agreement no [291734].\r\nI
  would like to thank Jan Kynčl and Dömötör Pálvölgyi for many comments and suggestions
  that helped to improve the presentation of the result."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
citation:
  ama: 'Fulek R. C-planarity of embedded cyclic c-graphs. In: Vol 9801. Springer;
    2016:94-106. doi:<a href="https://doi.org/10.1007/978-3-319-50106-2_8">10.1007/978-3-319-50106-2_8</a>'
  apa: 'Fulek, R. (2016). C-planarity of embedded cyclic c-graphs (Vol. 9801, pp.
    94–106). Presented at the GD: Graph Drawing and Network Visualization, Athens,
    Greece: Springer. <a href="https://doi.org/10.1007/978-3-319-50106-2_8">https://doi.org/10.1007/978-3-319-50106-2_8</a>'
  chicago: Fulek, Radoslav. “C-Planarity of Embedded Cyclic c-Graphs,” 9801:94–106.
    Springer, 2016. <a href="https://doi.org/10.1007/978-3-319-50106-2_8">https://doi.org/10.1007/978-3-319-50106-2_8</a>.
  ieee: 'R. Fulek, “C-planarity of embedded cyclic c-graphs,” presented at the GD:
    Graph Drawing and Network Visualization, Athens, Greece, 2016, vol. 9801, pp.
    94–106.'
  ista: 'Fulek R. 2016. C-planarity of embedded cyclic c-graphs. GD: Graph Drawing
    and Network Visualization, LNCS, vol. 9801, 94–106.'
  mla: Fulek, Radoslav. <i>C-Planarity of Embedded Cyclic c-Graphs</i>. Vol. 9801,
    Springer, 2016, pp. 94–106, doi:<a href="https://doi.org/10.1007/978-3-319-50106-2_8">10.1007/978-3-319-50106-2_8</a>.
  short: R. Fulek, in:, Springer, 2016, pp. 94–106.
conference:
  end_date: 2016-09-21
  location: Athens, Greece
  name: 'GD: Graph Drawing and Network Visualization'
  start_date: 2016-09-19
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-08T00:00:00Z
date_updated: 2025-09-22T09:54:03Z
day: '08'
department:
- _id: UlWa
doi: 10.1007/978-3-319-50106-2_8
ec_funded: 1
external_id:
  arxiv:
  - '1602.01346'
  isi:
  - '000405478500008'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1602.01346
month: '12'
oa: 1
oa_version: Preprint
page: 94 - 106
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Springer
publist_id: '6192'
quality_controlled: '1'
related_material:
  record:
  - id: '794'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: C-planarity of embedded cyclic c-graphs
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: '9801 '
year: '2016'
...
---
OA_place: repository
OA_type: green
_id: '1166'
abstract:
- lang: eng
  text: POMDPs are standard models for probabilistic planning problems, where an agent
    interacts with an uncertain environment. We study the problem of almost-sure reachability,
    where given a set of target states, the question is to decide whether there is
    a policy to ensure that the target set is reached with probability 1 (almost-surely).
    While in general the problem is EXPTIMEcomplete, in many practical cases policies
    with a small amount of memory suffice. Moreover, the existing solution to the
    problem is explicit, which first requires to construct explicitly an exponential
    reduction to a belief-support MDP. In this work, we first study the existence
    of observation-stationary strategies, which is NP-complete, and then small-memory
    strategies. We present a symbolic algorithm by an efficient encoding to SAT and
    using a SAT solver for the problem. We report experimental results demonstrating
    the scalability of our symbolic (SAT-based) approach. © 2016, Association for
    the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
  Grant No P23499-N23, FWF NFN Grant No S11407-N23 (RiSE), ERC Start grant (279307:
  Graph Games), and Microsoft faculty fellows award.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Chmelik, Martin
  id: 3624234E-F248-11E8-B48F-1D18A9856A87
  last_name: Chmelik
- first_name: Jessica
  full_name: Davies, Jessica
  id: 378E0060-F248-11E8-B48F-1D18A9856A87
  last_name: Davies
citation:
  ama: 'Chatterjee K, Chmelik M, Davies J. A symbolic SAT based algorithm for almost
    sure reachability with small strategies in POMDPs. In: <i>Proceedings of the Thirtieth
    AAAI Conference on Artificial Intelligence</i>. Vol 2016. AAAI Press; 2016:3225-3232.
    doi:<a href="https://doi.org/10.1609/aaai.v30i1.10422">10.1609/aaai.v30i1.10422</a>'
  apa: 'Chatterjee, K., Chmelik, M., &#38; Davies, J. (2016). A symbolic SAT based
    algorithm for almost sure reachability with small strategies in POMDPs. In <i>Proceedings
    of the Thirtieth AAAI Conference on Artificial Intelligence</i> (Vol. 2016, pp.
    3225–3232). Phoenix, AZ, United States: AAAI Press. <a href="https://doi.org/10.1609/aaai.v30i1.10422">https://doi.org/10.1609/aaai.v30i1.10422</a>'
  chicago: Chatterjee, Krishnendu, Martin Chmelik, and Jessica Davies. “A Symbolic
    SAT Based Algorithm for Almost Sure Reachability with Small Strategies in POMDPs.”
    In <i>Proceedings of the Thirtieth AAAI Conference on Artificial Intelligence</i>,
    2016:3225–32. AAAI Press, 2016. <a href="https://doi.org/10.1609/aaai.v30i1.10422">https://doi.org/10.1609/aaai.v30i1.10422</a>.
  ieee: K. Chatterjee, M. Chmelik, and J. Davies, “A symbolic SAT based algorithm
    for almost sure reachability with small strategies in POMDPs,” in <i>Proceedings
    of the Thirtieth AAAI Conference on Artificial Intelligence</i>, Phoenix, AZ,
    United States, 2016, vol. 2016, pp. 3225–3232.
  ista: 'Chatterjee K, Chmelik M, Davies J. 2016. A symbolic SAT based algorithm for
    almost sure reachability with small strategies in POMDPs. Proceedings of the Thirtieth
    AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence
    vol. 2016, 3225–3232.'
  mla: Chatterjee, Krishnendu, et al. “A Symbolic SAT Based Algorithm for Almost Sure
    Reachability with Small Strategies in POMDPs.” <i>Proceedings of the Thirtieth
    AAAI Conference on Artificial Intelligence</i>, vol. 2016, AAAI Press, 2016, pp.
    3225–32, doi:<a href="https://doi.org/10.1609/aaai.v30i1.10422">10.1609/aaai.v30i1.10422</a>.
  short: K. Chatterjee, M. Chmelik, J. Davies, in:, Proceedings of the Thirtieth AAAI
    Conference on Artificial Intelligence, AAAI Press, 2016, pp. 3225–3232.
conference:
  end_date: 2016-02-17
  location: Phoenix, AZ, United States
  name: 'AAAI: Conference on Artificial Intelligence'
  start_date: 2016-02-12
corr_author: '1'
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-02T00:00:00Z
date_updated: 2025-06-25T11:52:14Z
day: '02'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1609/aaai.v30i1.10422
ec_funded: 1
external_id:
  arxiv:
  - '1511.08456'
intvolume: '      2016'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1511.08456
month: '12'
oa: 1
oa_version: Preprint
page: 3225 - 3232
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication: Proceedings of the Thirtieth AAAI Conference on Artificial Intelligence
publication_status: published
publisher: AAAI Press
publist_id: '6191'
quality_controlled: '1'
related_material:
  link:
  - relation: table_of_contents
    url: https://dl.acm.org/citation.cfm?id=3016355
  record:
  - id: '5443'
    relation: earlier_version
    status: public
status: public
title: A symbolic SAT based algorithm for almost sure reachability with small strategies
  in POMDPs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2016
year: '2016'
...
---
_id: '1167'
abstract:
- lang: eng
  text: Evolutionary pathways describe trajectories of biological evolution in the
    space of different variants of organisms (genotypes). The probability of existence
    and the number of evolutionary pathways that lead from a given genotype to a better-adapted
    genotype are important measures of accessibility of local fitness optima and the
    reproducibility of evolution. Both quantities have been studied in simple mathematical
    models where genotypes are represented as binary sequences of two types of basic
    units, and the network of permitted mutations between the genotypes is a hypercube
    graph. However, it is unclear how these results translate to the biologically
    relevant case in which genotypes are represented by sequences of more than two
    units, for example four nucleotides (DNA) or 20 amino acids (proteins), and the
    mutational graph is not the hypercube. Here we investigate accessibility of the
    best-adapted genotype in the general case of K &gt; 2 units. Using computer generated
    and experimental fitness landscapes we show that accessibility of the global fitness
    maximum increases with K and can be much higher than for binary sequences. The
    increase in accessibility comes from the increase in the number of indirect trajectories
    exploited by evolution for higher K. As one of the consequences, the fraction
    of genotypes that are accessible increases by three orders of magnitude when the
    number of units K increases from 2 to 16 for landscapes of size N ∼ 106genotypes.
    This suggests that evolution can follow many different trajectories on such landscapes
    and the reconstruction of evolutionary pathways from experimental data might be
    an extremely difficult task.
acknowledgement: MZ acknowledges the Polish National Science Centre grant no. DEC-2012/07/N/NZ2/00107.
  BW was supported by the Scottish Government/Royal Society of Edinburgh Personal
  Research Fellowship. We thank Marjon de Vos and Oliver Martin for critically reading
  the manuscript.
article_number: e1005218
article_processing_charge: No
author:
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Zdzisław
  full_name: Burda, Zdzisław
  last_name: Burda
- first_name: Bartłomiej
  full_name: Wacław, Bartłomiej
  last_name: Wacław
citation:
  ama: Zagórski MP, Burda Z, Wacław B. Beyond the hypercube evolutionary accessibility
    of fitness landscapes with realistic mutational networks. <i>PLoS Computational
    Biology</i>. 2016;12(12). doi:<a href="https://doi.org/10.1371/journal.pcbi.1005218">10.1371/journal.pcbi.1005218</a>
  apa: Zagórski, M. P., Burda, Z., &#38; Wacław, B. (2016). Beyond the hypercube evolutionary
    accessibility of fitness landscapes with realistic mutational networks. <i>PLoS
    Computational Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1005218">https://doi.org/10.1371/journal.pcbi.1005218</a>
  chicago: Zagórski, Marcin P, Zdzisław Burda, and Bartłomiej Wacław. “Beyond the
    Hypercube Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational
    Networks.” <i>PLoS Computational Biology</i>. Public Library of Science, 2016.
    <a href="https://doi.org/10.1371/journal.pcbi.1005218">https://doi.org/10.1371/journal.pcbi.1005218</a>.
  ieee: M. P. Zagórski, Z. Burda, and B. Wacław, “Beyond the hypercube evolutionary
    accessibility of fitness landscapes with realistic mutational networks,” <i>PLoS
    Computational Biology</i>, vol. 12, no. 12. Public Library of Science, 2016.
  ista: Zagórski MP, Burda Z, Wacław B. 2016. Beyond the hypercube evolutionary accessibility
    of fitness landscapes with realistic mutational networks. PLoS Computational Biology.
    12(12), e1005218.
  mla: Zagórski, Marcin P., et al. “Beyond the Hypercube Evolutionary Accessibility
    of Fitness Landscapes with Realistic Mutational Networks.” <i>PLoS Computational
    Biology</i>, vol. 12, no. 12, e1005218, Public Library of Science, 2016, doi:<a
    href="https://doi.org/10.1371/journal.pcbi.1005218">10.1371/journal.pcbi.1005218</a>.
  short: M.P. Zagórski, Z. Burda, B. Wacław, PLoS Computational Biology 12 (2016).
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-09T00:00:00Z
date_updated: 2025-09-22T09:53:16Z
day: '09'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1371/journal.pcbi.1005218
external_id:
  isi:
  - '000392126000015'
file:
- access_level: open_access
  checksum: 84f44ae92866c52ff1ca8a574558dca7
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:08Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4926'
  file_name: IST-2017-740-v1+1_journal.pcbi.1005218.pdf
  file_size: 3822299
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
has_accepted_license: '1'
intvolume: '        12'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: PLoS Computational Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6190'
pubrep_id: '740'
quality_controlled: '1'
related_material:
  record:
  - id: '9866'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Beyond the hypercube evolutionary accessibility of fitness landscapes with
  realistic mutational networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 12
year: '2016'
...
---
OA_place: repository
OA_type: green
_id: '1170'
abstract:
- lang: eng
  text: The increasing complexity of dynamic models in systems and synthetic biology
    poses computational challenges especially for the identification of model parameters.
    While modularization of the corresponding optimization problems could help reduce
    the “curse of dimensionality,” abundant feedback and crosstalk mechanisms prohibit
    a simple decomposition of most biomolecular networks into subnetworks, or modules.
    Drawing on ideas from network modularization and multiple-shooting optimization,
    we present here a modular parameter identification approach that explicitly allows
    for such interdependencies. Interfaces between our modules are given by the experimentally
    measured molecular species. This definition allows deriving good (initial) estimates
    for the inter-module communication directly from the experimental data. Given
    these estimates, the states and parameter sensitivities of different modules can
    be integrated independently. To achieve consistency between modules, we iteratively
    adjust the estimates for inter-module communication while optimizing the parameters.
    After convergence to an optimal parameter set---but not during earlier iterations---the
    intermodule communication as well as the individual modules\' state dynamics agree
    with the dynamics of the nonmodularized network. Our modular parameter identification
    approach allows for easy parallelization; it can reduce the computational complexity
    for larger networks and decrease the probability to converge to suboptimal local
    minima. We demonstrate the algorithm\'s performance in parameter estimation for
    two biomolecular networks, a synthetic genetic oscillator and a mammalian signaling
    pathway.
article_processing_charge: No
article_type: original
author:
- first_name: Moritz
  full_name: Lang, Moritz
  id: 29E0800A-F248-11E8-B48F-1D18A9856A87
  last_name: Lang
- first_name: Jörg
  full_name: Stelling, Jörg
  last_name: Stelling
citation:
  ama: Lang M, Stelling J. Modular parameter identification of biomolecular networks.
    <i>SIAM Journal on Scientific Computing</i>. 2016;38(6):B988-B1008. doi:<a href="https://doi.org/10.1137/15M103306X">10.1137/15M103306X</a>
  apa: Lang, M., &#38; Stelling, J. (2016). Modular parameter identification of biomolecular
    networks. <i>SIAM Journal on Scientific Computing</i>. Society for Industrial
    and Applied Mathematics . <a href="https://doi.org/10.1137/15M103306X">https://doi.org/10.1137/15M103306X</a>
  chicago: Lang, Moritz, and Jörg Stelling. “Modular Parameter Identification of Biomolecular
    Networks.” <i>SIAM Journal on Scientific Computing</i>. Society for Industrial
    and Applied Mathematics , 2016. <a href="https://doi.org/10.1137/15M103306X">https://doi.org/10.1137/15M103306X</a>.
  ieee: M. Lang and J. Stelling, “Modular parameter identification of biomolecular
    networks,” <i>SIAM Journal on Scientific Computing</i>, vol. 38, no. 6. Society
    for Industrial and Applied Mathematics , pp. B988–B1008, 2016.
  ista: Lang M, Stelling J. 2016. Modular parameter identification of biomolecular
    networks. SIAM Journal on Scientific Computing. 38(6), B988–B1008.
  mla: Lang, Moritz, and Jörg Stelling. “Modular Parameter Identification of Biomolecular
    Networks.” <i>SIAM Journal on Scientific Computing</i>, vol. 38, no. 6, Society
    for Industrial and Applied Mathematics , 2016, pp. B988–1008, doi:<a href="https://doi.org/10.1137/15M103306X">10.1137/15M103306X</a>.
  short: M. Lang, J. Stelling, SIAM Journal on Scientific Computing 38 (2016) B988–B1008.
corr_author: '1'
date_created: 2018-12-11T11:50:31Z
date_published: 2016-11-15T00:00:00Z
date_updated: 2025-09-22T09:51:45Z
day: '15'
ddc:
- '003'
- '518'
- '570'
- '621'
department:
- _id: CaGu
- _id: GaTk
doi: 10.1137/15M103306X
external_id:
  isi:
  - '000391853100010'
file:
- access_level: open_access
  checksum: 781bc3ffd30b2dd65b7727c5a285fc78
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:41Z
  date_updated: 2025-06-25T11:26:45Z
  file_id: '5095'
  file_name: IST-2017-811-v1+1_modular_parameter_identification.pdf
  file_size: 871964
  relation: main_file
file_date_updated: 2025-06-25T11:26:45Z
has_accepted_license: '1'
intvolume: '        38'
isi: 1
issue: '6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: B988 - B1008
publication: SIAM Journal on Scientific Computing
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '6186'
pubrep_id: '811'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modular parameter identification of biomolecular networks
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 38
year: '2016'
...
---
_id: '1171'
article_processing_charge: No
author:
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: 'Tkačik G. Understanding regulatory networks requires more than computing a
    multitude of graph statistics: Comment on &#38;quot;Drivers of structural features
    in gene regulatory networks: From biophysical constraints to biological function&#38;quot;
    by O. C. Martin et al. <i>Physics of Life Reviews</i>. 2016;17:166-167. doi:<a
    href="https://doi.org/10.1016/j.plrev.2016.06.005">10.1016/j.plrev.2016.06.005</a>'
  apa: 'Tkačik, G. (2016). Understanding regulatory networks requires more than computing
    a multitude of graph statistics: Comment on &#38;quot;Drivers of structural features
    in gene regulatory networks: From biophysical constraints to biological function&#38;quot;
    by O. C. Martin et al. <i>Physics of Life Reviews</i>. Elsevier. <a href="https://doi.org/10.1016/j.plrev.2016.06.005">https://doi.org/10.1016/j.plrev.2016.06.005</a>'
  chicago: 'Tkačik, Gašper. “Understanding Regulatory Networks Requires More than
    Computing a Multitude of Graph Statistics: Comment on &#38;quot;Drivers of Structural
    Features in Gene Regulatory Networks: From Biophysical Constraints to Biological
    Function&#38;quot; by O. C. Martin et Al.” <i>Physics of Life Reviews</i>. Elsevier,
    2016. <a href="https://doi.org/10.1016/j.plrev.2016.06.005">https://doi.org/10.1016/j.plrev.2016.06.005</a>.'
  ieee: 'G. Tkačik, “Understanding regulatory networks requires more than computing
    a multitude of graph statistics: Comment on &#38;quot;Drivers of structural features
    in gene regulatory networks: From biophysical constraints to biological function&#38;quot;
    by O. C. Martin et al.,” <i>Physics of Life Reviews</i>, vol. 17. Elsevier, pp.
    166–167, 2016.'
  ista: 'Tkačik G. 2016. Understanding regulatory networks requires more than computing
    a multitude of graph statistics: Comment on &#38;quot;Drivers of structural features
    in gene regulatory networks: From biophysical constraints to biological function&#38;quot;
    by O. C. Martin et al. Physics of Life Reviews. 17, 166–167.'
  mla: 'Tkačik, Gašper. “Understanding Regulatory Networks Requires More than Computing
    a Multitude of Graph Statistics: Comment on &#38;quot;Drivers of Structural Features
    in Gene Regulatory Networks: From Biophysical Constraints to Biological Function&#38;quot;
    by O. C. Martin et Al.” <i>Physics of Life Reviews</i>, vol. 17, Elsevier, 2016,
    pp. 166–67, doi:<a href="https://doi.org/10.1016/j.plrev.2016.06.005">10.1016/j.plrev.2016.06.005</a>.'
  short: G. Tkačik, Physics of Life Reviews 17 (2016) 166–167.
date_created: 2018-12-11T11:50:32Z
date_published: 2016-07-01T00:00:00Z
date_updated: 2025-09-22T09:50:37Z
day: '01'
department:
- _id: GaTk
doi: 10.1016/j.plrev.2016.06.005
external_id:
  isi:
  - '000381544100033'
intvolume: '        17'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 166 - 167
publication: Physics of Life Reviews
publication_status: published
publisher: Elsevier
publist_id: '6185'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Understanding regulatory networks requires more than computing a multitude
  of graph statistics: Comment on &quot;Drivers of structural features in gene regulatory
  networks: From biophysical constraints to biological function&quot; by O. C. Martin
  et al.'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 17
year: '2016'
...
---
_id: '1172'
abstract:
- lang: eng
  text: A central issue in cell biology is the physico-chemical basis of organelle
    biogenesis in intracellular trafficking pathways, its most impressive manifestation
    being the biogenesis of Golgi cisternae. At a basic level, such morphologically
    and chemically distinct compartments should arise from an interplay between the
    molecular transport and chemical maturation. Here, we formulate analytically tractable,
    minimalist models, that incorporate this interplay between transport and chemical
    progression in physical space, and explore the conditions for de novo biogenesis
    of distinct cisternae. We propose new quantitative measures that can discriminate
    between the various models of transport in a qualitative manner-this includes
    measures of the dynamics in steady state and the dynamical response to perturbations
    of the kind amenable to live-cell imaging.
acknowledgement: H.S. thanks NCBS for hospitality. We thank Vivek Malhotra and Mukund
  Thattai for critical discussions and suggestions.
article_number: '38840'
article_processing_charge: No
author:
- first_name: Himani
  full_name: Sachdeva, Himani
  id: 42377A0A-F248-11E8-B48F-1D18A9856A87
  last_name: Sachdeva
- first_name: Mustansir
  full_name: Barma, Mustansir
  last_name: Barma
- first_name: Madan
  full_name: Rao, Madan
  last_name: Rao
citation:
  ama: Sachdeva H, Barma M, Rao M. Nonequilibrium description of de novo biogenesis
    and transport through Golgi-like cisternae. <i>Scientific Reports</i>. 2016;6.
    doi:<a href="https://doi.org/10.1038/srep38840">10.1038/srep38840</a>
  apa: Sachdeva, H., Barma, M., &#38; Rao, M. (2016). Nonequilibrium description of
    de novo biogenesis and transport through Golgi-like cisternae. <i>Scientific Reports</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/srep38840">https://doi.org/10.1038/srep38840</a>
  chicago: Sachdeva, Himani, Mustansir Barma, and Madan Rao. “Nonequilibrium Description
    of de Novo Biogenesis and Transport through Golgi-like Cisternae.” <i>Scientific
    Reports</i>. Nature Publishing Group, 2016. <a href="https://doi.org/10.1038/srep38840">https://doi.org/10.1038/srep38840</a>.
  ieee: H. Sachdeva, M. Barma, and M. Rao, “Nonequilibrium description of de novo
    biogenesis and transport through Golgi-like cisternae,” <i>Scientific Reports</i>,
    vol. 6. Nature Publishing Group, 2016.
  ista: Sachdeva H, Barma M, Rao M. 2016. Nonequilibrium description of de novo biogenesis
    and transport through Golgi-like cisternae. Scientific Reports. 6, 38840.
  mla: Sachdeva, Himani, et al. “Nonequilibrium Description of de Novo Biogenesis
    and Transport through Golgi-like Cisternae.” <i>Scientific Reports</i>, vol. 6,
    38840, Nature Publishing Group, 2016, doi:<a href="https://doi.org/10.1038/srep38840">10.1038/srep38840</a>.
  short: H. Sachdeva, M. Barma, M. Rao, Scientific Reports 6 (2016).
date_created: 2018-12-11T11:50:32Z
date_published: 2016-12-19T00:00:00Z
date_updated: 2025-09-22T09:49:53Z
day: '19'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1038/srep38840
external_id:
  isi:
  - '000389885900001'
file:
- access_level: open_access
  checksum: cb378732da885ea4959ec5b845fb6e52
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:56Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4977'
  file_name: IST-2017-737-v1+1_srep38840.pdf
  file_size: 760967
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6183'
pubrep_id: '737'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonequilibrium description of de novo biogenesis and transport through Golgi-like
  cisternae
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1177'
abstract:
- lang: eng
  text: Boldyreva, Palacio and Warinschi introduced a multiple forking game as an
    extension of general forking. The notion of (multiple) forking is a useful abstraction
    from the actual simulation of cryptographic scheme to the adversary in a security
    reduction, and is achieved through the intermediary of a so-called wrapper algorithm.
    Multiple forking has turned out to be a useful tool in the security argument of
    several cryptographic protocols. However, a reduction employing multiple forking
    incurs a significant degradation of (Formula presented.) , where (Formula presented.)
    denotes the upper bound on the underlying random oracle calls and (Formula presented.)
    , the number of forkings. In this work we take a closer look at the reasons for
    the degradation with a tighter security bound in mind. We nail down the exact
    set of conditions for success in the multiple forking game. A careful analysis
    of the cryptographic schemes and corresponding security reduction employing multiple
    forking leads to the formulation of ‘dependence’ and ‘independence’ conditions
    pertaining to the output of the wrapper in different rounds. Based on the (in)dependence
    conditions we propose a general framework of multiple forking and a General Multiple
    Forking Lemma. Leveraging (in)dependence to the full allows us to improve the
    degradation factor in the multiple forking game by a factor of (Formula presented.).
    By implication, the cost of a single forking involving two random oracles (augmented
    forking) matches that involving a single random oracle (elementary forking). Finally,
    we study the effect of these observations on the concrete security of existing
    schemes employing multiple forking. We conclude that by careful design of the
    protocol (and the wrapper in the security reduction) it is possible to harness
    our observations to the full extent.
acknowledgement: "We are grateful to the anonymous reviewers for their insightful
  comments. The\r\ndetailed reports helped us a lot to address the technical mistakes
  as well as to improve the overall presentation of the paper."
article_processing_charge: No
author:
- first_name: Chethan
  full_name: Kamath Hosdurg, Chethan
  id: 4BD3F30E-F248-11E8-B48F-1D18A9856A87
  last_name: Kamath Hosdurg
- first_name: Sanjit
  full_name: Chatterjee, Sanjit
  last_name: Chatterjee
citation:
  ama: 'Kamath Hosdurg C, Chatterjee S. A closer look at multiple-forking: Leveraging
    (in)dependence for a tighter bound. <i>Algorithmica</i>. 2016;74(4):1321-1362.
    doi:<a href="https://doi.org/10.1007/s00453-015-9997-6">10.1007/s00453-015-9997-6</a>'
  apa: 'Kamath Hosdurg, C., &#38; Chatterjee, S. (2016). A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound. <i>Algorithmica</i>. Springer.
    <a href="https://doi.org/10.1007/s00453-015-9997-6">https://doi.org/10.1007/s00453-015-9997-6</a>'
  chicago: 'Kamath Hosdurg, Chethan, and Sanjit Chatterjee. “A Closer Look at Multiple-Forking:
    Leveraging (in)Dependence for a Tighter Bound.” <i>Algorithmica</i>. Springer,
    2016. <a href="https://doi.org/10.1007/s00453-015-9997-6">https://doi.org/10.1007/s00453-015-9997-6</a>.'
  ieee: 'C. Kamath Hosdurg and S. Chatterjee, “A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound,” <i>Algorithmica</i>, vol. 74,
    no. 4. Springer, pp. 1321–1362, 2016.'
  ista: 'Kamath Hosdurg C, Chatterjee S. 2016. A closer look at multiple-forking:
    Leveraging (in)dependence for a tighter bound. Algorithmica. 74(4), 1321–1362.'
  mla: 'Kamath Hosdurg, Chethan, and Sanjit Chatterjee. “A Closer Look at Multiple-Forking:
    Leveraging (in)Dependence for a Tighter Bound.” <i>Algorithmica</i>, vol. 74,
    no. 4, Springer, 2016, pp. 1321–62, doi:<a href="https://doi.org/10.1007/s00453-015-9997-6">10.1007/s00453-015-9997-6</a>.'
  short: C. Kamath Hosdurg, S. Chatterjee, Algorithmica 74 (2016) 1321–1362.
date_created: 2018-12-11T11:50:33Z
date_published: 2016-04-01T00:00:00Z
date_updated: 2025-09-22T09:49:20Z
day: '01'
department:
- _id: KrPi
doi: 10.1007/s00453-015-9997-6
external_id:
  isi:
  - '000373640000005'
intvolume: '        74'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://eprint.iacr.org/2013/651
month: '04'
oa: 1
oa_version: Submitted Version
page: 1321 - 1362
publication: Algorithmica
publication_status: published
publisher: Springer
publist_id: '6177'
quality_controlled: '1'
status: public
title: 'A closer look at multiple-forking: Leveraging (in)dependence for a tighter
  bound'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 74
year: '2016'
...
---
_id: '1179'
abstract:
- lang: eng
  text: "Computational notions of entropy have recently found many applications, including
    leakage-resilient cryptography, deterministic encryption or memory delegation.
    The two main types of results which make computational notions so useful are (1)
    Chain rules, which quantify by how much the computational entropy of a variable
    decreases if conditioned on some other variable (2) Transformations, which quantify
    to which extend one type of entropy implies another.\r\n\r\nSuch chain rules and
    transformations typically lose a significant amount in quality of the entropy,
    and are the reason why applying these results one gets rather weak quantitative
    security bounds. In this paper we for the first time prove lower bounds in this
    context, showing that existing results for transformations are, unfortunately,
    basically optimal for non-adaptive black-box reductions (and it’s hard to imagine
    how non black-box reductions or adaptivity could be useful here.)\r\n\r\nA variable
    X has k bits of HILL entropy of quality (ϵ,s)\r\nif there exists a variable Y
    with k bits min-entropy which cannot be distinguished from X with advantage ϵ\r\n\r\nby
    distinguishing circuits of size s. A weaker notion is Metric entropy, where we
    switch quantifiers, and only require that for every distinguisher of size s, such
    a Y exists.\r\n\r\nWe first describe our result concerning transformations. By
    definition, HILL implies Metric without any loss in quality. Metric entropy often
    comes up in applications, but must be transformed to HILL for meaningful security
    guarantees. The best known result states that if a variable X has k bits of Metric
    entropy of quality (ϵ,s)\r\n, then it has k bits of HILL with quality (2ϵ,s⋅ϵ2).
    We show that this loss of a factor Ω(ϵ−2)\r\n\r\nin circuit size is necessary.
    In fact, we show the stronger result that this loss is already necessary when
    transforming so called deterministic real valued Metric entropy to randomised
    boolean Metric (both these variants of Metric entropy are implied by HILL without
    loss in quality).\r\n\r\nThe chain rule for HILL entropy states that if X has
    k bits of HILL entropy of quality (ϵ,s)\r\n, then for any variable Z of length
    m, X conditioned on Z has k−m bits of HILL entropy with quality (ϵ,s⋅ϵ2/2m). We
    show that a loss of Ω(2m/ϵ) in circuit size necessary here. Note that this still
    leaves a gap of ϵ between the known bound and our lower bound."
acknowledgement: "K. Pietrzak—Supported by the European Research Council consolidator
  grant (682815-TOCNeT).\r\nM. Skórski—Supported by the National Science Center, Poland
  (2015/17/N/ST6/03564)."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Skorski
  full_name: Maciej, Skorski
  last_name: Maciej
citation:
  ama: 'Pietrzak KZ, Maciej S. Pseudoentropy: Lower-bounds for chain rules and transformations.
    In: Vol 9985. Springer; 2016:183-203. doi:<a href="https://doi.org/10.1007/978-3-662-53641-4_8">10.1007/978-3-662-53641-4_8</a>'
  apa: 'Pietrzak, K. Z., &#38; Maciej, S. (2016). Pseudoentropy: Lower-bounds for
    chain rules and transformations (Vol. 9985, pp. 183–203). Presented at the TCC:
    Theory of Cryptography Conference, Beijing, China: Springer. <a href="https://doi.org/10.1007/978-3-662-53641-4_8">https://doi.org/10.1007/978-3-662-53641-4_8</a>'
  chicago: 'Pietrzak, Krzysztof Z, and Skorski Maciej. “Pseudoentropy: Lower-Bounds
    for Chain Rules and Transformations,” 9985:183–203. Springer, 2016. <a href="https://doi.org/10.1007/978-3-662-53641-4_8">https://doi.org/10.1007/978-3-662-53641-4_8</a>.'
  ieee: 'K. Z. Pietrzak and S. Maciej, “Pseudoentropy: Lower-bounds for chain rules
    and transformations,” presented at the TCC: Theory of Cryptography Conference,
    Beijing, China, 2016, vol. 9985, pp. 183–203.'
  ista: 'Pietrzak KZ, Maciej S. 2016. Pseudoentropy: Lower-bounds for chain rules
    and transformations. TCC: Theory of Cryptography Conference, LNCS, vol. 9985,
    183–203.'
  mla: 'Pietrzak, Krzysztof Z., and Skorski Maciej. <i>Pseudoentropy: Lower-Bounds
    for Chain Rules and Transformations</i>. Vol. 9985, Springer, 2016, pp. 183–203,
    doi:<a href="https://doi.org/10.1007/978-3-662-53641-4_8">10.1007/978-3-662-53641-4_8</a>.'
  short: K.Z. Pietrzak, S. Maciej, in:, Springer, 2016, pp. 183–203.
conference:
  end_date: 2016-11-03
  location: Beijing, China
  name: 'TCC: Theory of Cryptography Conference'
  start_date: 2016-10-31
date_created: 2018-12-11T11:50:34Z
date_published: 2016-10-22T00:00:00Z
date_updated: 2025-09-22T09:48:49Z
day: '22'
department:
- _id: KrPi
doi: 10.1007/978-3-662-53641-4_8
ec_funded: 1
external_id:
  isi:
  - '000390176000008'
intvolume: '      9985'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2016/159
month: '10'
oa: 1
oa_version: Preprint
page: 183 - 203
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
publication_status: published
publisher: Springer
publist_id: '6175'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pseudoentropy: Lower-bounds for chain rules and transformations'
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9985
year: '2016'
...
---
_id: '1181'
abstract:
- lang: eng
  text: 'This review accompanies a 2016 SFN mini-symposium presenting examples of
    current studies that address a central question: How do neural stem cells (NSCs)
    divide in different ways to produce heterogeneous daughter types at the right
    time and in proper numbers to build a cerebral cortex with the appropriate size
    and structure? We will focus on four aspects of corticogenesis: cytokinesis events
    that follow apical mitoses of NSCs; coordinating abscission with delamination
    from the apical membrane; timing of neurogenesis and its indirect regulation through
    emergence of intermediate progenitors; and capacity of single NSCs to generate
    the correct number and laminar fate of cortical neurons. Defects in these mechanisms
    can cause microcephaly and other brain malformations, and understanding them is
    critical to designing diagnostic tools and preventive and corrective therapies.'
acknowledgement: This work was supported by National Institutes of Health Grants R01NS089795
  and R01NS098370 to H.T.G., R01NS076640 to N.D.D., and R01MH094589 and R01NS089777
  to B.C., Academia Sinica AS-104-TPB09-2 to S.-J.C, European Union FP7-CIG618444
  and Human Frontiers Science Program RGP0053 to S.H., and Fonds Léon Fredericq, from
  the Fondation Médicale Reine Elisabeth, and from the Fonation Simone et Pierre Clerdent
  to L.N. The authors apologize to colleagues whose work could not be cited due to
  space limitations.
article_processing_charge: No
author:
- first_name: Noelle
  full_name: Dwyer, Noelle
  last_name: Dwyer
- first_name: Bin
  full_name: Chen, Bin
  last_name: Chen
- first_name: Shen
  full_name: Chou, Shen
  last_name: Chou
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Laurent
  full_name: Nguyen, Laurent
  last_name: Nguyen
- first_name: Troy
  full_name: Ghashghaei, Troy
  last_name: Ghashghaei
citation:
  ama: 'Dwyer N, Chen B, Chou S, Hippenmeyer S, Nguyen L, Ghashghaei T. Neural stem
    cells to cerebral cortex: Emerging mechanisms regulating progenitor behavior and
    productivity. <i>Journal of Neuroscience</i>. 2016;36(45):11394-11401. doi:<a
    href="https://doi.org/10.1523/JNEUROSCI.2359-16.2016">10.1523/JNEUROSCI.2359-16.2016</a>'
  apa: 'Dwyer, N., Chen, B., Chou, S., Hippenmeyer, S., Nguyen, L., &#38; Ghashghaei,
    T. (2016). Neural stem cells to cerebral cortex: Emerging mechanisms regulating
    progenitor behavior and productivity. <i>Journal of Neuroscience</i>. Society
    for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.2359-16.2016">https://doi.org/10.1523/JNEUROSCI.2359-16.2016</a>'
  chicago: 'Dwyer, Noelle, Bin Chen, Shen Chou, Simon Hippenmeyer, Laurent Nguyen,
    and Troy Ghashghaei. “Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms
    Regulating Progenitor Behavior and Productivity.” <i>Journal of Neuroscience</i>.
    Society for Neuroscience, 2016. <a href="https://doi.org/10.1523/JNEUROSCI.2359-16.2016">https://doi.org/10.1523/JNEUROSCI.2359-16.2016</a>.'
  ieee: 'N. Dwyer, B. Chen, S. Chou, S. Hippenmeyer, L. Nguyen, and T. Ghashghaei,
    “Neural stem cells to cerebral cortex: Emerging mechanisms regulating progenitor
    behavior and productivity,” <i>Journal of Neuroscience</i>, vol. 36, no. 45. Society
    for Neuroscience, pp. 11394–11401, 2016.'
  ista: 'Dwyer N, Chen B, Chou S, Hippenmeyer S, Nguyen L, Ghashghaei T. 2016. Neural
    stem cells to cerebral cortex: Emerging mechanisms regulating progenitor behavior
    and productivity. Journal of Neuroscience. 36(45), 11394–11401.'
  mla: 'Dwyer, Noelle, et al. “Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms
    Regulating Progenitor Behavior and Productivity.” <i>Journal of Neuroscience</i>,
    vol. 36, no. 45, Society for Neuroscience, 2016, pp. 11394–401, doi:<a href="https://doi.org/10.1523/JNEUROSCI.2359-16.2016">10.1523/JNEUROSCI.2359-16.2016</a>.'
  short: N. Dwyer, B. Chen, S. Chou, S. Hippenmeyer, L. Nguyen, T. Ghashghaei, Journal
    of Neuroscience 36 (2016) 11394–11401.
date_created: 2018-12-11T11:50:35Z
date_published: 2016-11-09T00:00:00Z
date_updated: 2025-09-22T09:48:17Z
day: '09'
department:
- _id: SiHi
doi: 10.1523/JNEUROSCI.2359-16.2016
external_id:
  isi:
  - '000391054300003'
intvolume: '        36'
isi: 1
issue: '45'
language:
- iso: eng
month: '11'
oa_version: None
page: 11394 - 11401
project:
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '6172'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Neural stem cells to cerebral cortex: Emerging mechanisms regulating progenitor
  behavior and productivity'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 36
year: '2016'
...
---
_id: '1182'
abstract:
- lang: eng
  text: 'Balanced knockout tournaments are ubiquitous in sports competitions and are
    also used in decisionmaking and elections. The traditional computational question,
    that asks to compute a draw (optimal draw) that maximizes the winning probability
    for a distinguished player, has received a lot of attention. Previous works consider
    the problem where the pairwise winning probabilities are known precisely, while
    we study how robust is the winning probability with respect to small errors in
    the pairwise winning probabilities. First, we present several illuminating examples
    to establish: (a) there exist deterministic tournaments (where the pairwise winning
    probabilities are 0 or 1) where one optimal draw is much more robust than the
    other; and (b) in general, there exist tournaments with slightly suboptimal draws
    that are more robust than all the optimal draws. The above examples motivate the
    study of the computational problem of robust draws that guarantee a specified
    winning probability. Second, we present a polynomial-time algorithm for approximating
    the robustness of a draw for sufficiently small errors in pairwise winning probabilities,
    and obtain that the stated computational problem is NP-complete. We also show
    that two natural cases of deterministic tournaments where the optimal draw could
    be computed in polynomial time also admit polynomial-time algorithms to compute
    robust optimal draws.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
citation:
  ama: 'Chatterjee K, Ibsen-Jensen R, Tkadlec J. Robust draws in balanced knockout
    tournaments. In: Vol 2016-January. AAAI Press; 2016:172-179.'
  apa: 'Chatterjee, K., Ibsen-Jensen, R., &#38; Tkadlec, J. (2016). Robust draws in
    balanced knockout tournaments (Vol. 2016–January, pp. 172–179). Presented at the
    IJCAI: International Joint Conference on Artificial Intelligence, New York, NY,
    USA: AAAI Press.'
  chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Josef Tkadlec. “Robust
    Draws in Balanced Knockout Tournaments,” 2016–January:172–79. AAAI Press, 2016.
  ieee: 'K. Chatterjee, R. Ibsen-Jensen, and J. Tkadlec, “Robust draws in balanced
    knockout tournaments,” presented at the IJCAI: International Joint Conference
    on Artificial Intelligence, New York, NY, USA, 2016, vol. 2016–January, pp. 172–179.'
  ista: 'Chatterjee K, Ibsen-Jensen R, Tkadlec J. 2016. Robust draws in balanced knockout
    tournaments. IJCAI: International Joint Conference on Artificial Intelligence
    vol. 2016–January, 172–179.'
  mla: Chatterjee, Krishnendu, et al. <i>Robust Draws in Balanced Knockout Tournaments</i>.
    Vol. 2016–January, AAAI Press, 2016, pp. 172–79.
  short: K. Chatterjee, R. Ibsen-Jensen, J. Tkadlec, in:, AAAI Press, 2016, pp. 172–179.
conference:
  end_date: 2016-07-15
  location: New York, NY, USA
  name: 'IJCAI: International Joint Conference on Artificial Intelligence'
  start_date: 2016-07-09
corr_author: '1'
date_created: 2018-12-11T11:50:35Z
date_published: 2016-01-01T00:00:00Z
date_updated: 2025-04-22T13:42:22Z
day: '01'
department:
- _id: KrCh
ec_funded: 1
external_id:
  arxiv:
  - '1604.05090'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1604.05090
month: '01'
oa: 1
oa_version: Preprint
page: 172 - 179
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication_status: published
publisher: AAAI Press
publist_id: '6171'
quality_controlled: '1'
related_material:
  link:
  - relation: table_of_contents
    url: https://www.ijcai.org/proceedings/2016
scopus_import: '1'
status: public
title: Robust draws in balanced knockout tournaments
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2016-January
year: '2016'
...
---
_id: '1184'
abstract:
- lang: eng
  text: Across multicellular organisms, the costs of reproduction and self-maintenance
    result in a life history trade-off between fecundity and longevity. Queens of
    perennial social Hymenoptera are both highly fertile and long-lived, and thus,
    this fundamental trade-off is lacking. Whether social insect males similarly evade
    the fecundity/longevity trade-off remains largely unstudied. Wingless males of
    the ant genus Cardiocondyla stay in their natal colonies throughout their relatively
    long lives and mate with multiple female sexuals. Here, we show that Cardiocondyla
    obscurior males that were allowed to mate with large numbers of female sexuals
    had a shortened life span compared to males that mated at a low frequency or virgin
    males. Although frequent mating negatively affects longevity, males clearly benefit
    from a “live fast, die young strategy” by inseminating as many female sexuals
    as possible at a cost to their own survival.
acknowledgement: 'German Science Foundation. Grant Number: SCHR 1135/2-1. We thank
  M. Adam for handling part of the setups and J. Zoellner for behavioral observations.'
article_processing_charge: No
author:
- first_name: Sina
  full_name: Metzler, Sina
  id: 48204546-F248-11E8-B48F-1D18A9856A87
  last_name: Metzler
  orcid: 0000-0002-9547-2494
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
- first_name: Alexandra
  full_name: Schrempf, Alexandra
  last_name: Schrempf
citation:
  ama: Metzler S, Heinze J, Schrempf A. Mating and longevity in ant males. <i>Ecology
    and Evolution</i>. 2016;6(24):8903-8906. doi:<a href="https://doi.org/10.1002/ece3.2474">10.1002/ece3.2474</a>
  apa: Metzler, S., Heinze, J., &#38; Schrempf, A. (2016). Mating and longevity in
    ant males. <i>Ecology and Evolution</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/ece3.2474">https://doi.org/10.1002/ece3.2474</a>
  chicago: Metzler, Sina, Jürgen Heinze, and Alexandra Schrempf. “Mating and Longevity
    in Ant Males.” <i>Ecology and Evolution</i>. Wiley-Blackwell, 2016. <a href="https://doi.org/10.1002/ece3.2474">https://doi.org/10.1002/ece3.2474</a>.
  ieee: S. Metzler, J. Heinze, and A. Schrempf, “Mating and longevity in ant males,”
    <i>Ecology and Evolution</i>, vol. 6, no. 24. Wiley-Blackwell, pp. 8903–8906,
    2016.
  ista: Metzler S, Heinze J, Schrempf A. 2016. Mating and longevity in ant males.
    Ecology and Evolution. 6(24), 8903–8906.
  mla: Metzler, Sina, et al. “Mating and Longevity in Ant Males.” <i>Ecology and Evolution</i>,
    vol. 6, no. 24, Wiley-Blackwell, 2016, pp. 8903–06, doi:<a href="https://doi.org/10.1002/ece3.2474">10.1002/ece3.2474</a>.
  short: S. Metzler, J. Heinze, A. Schrempf, Ecology and Evolution 6 (2016) 8903–8906.
date_created: 2018-12-11T11:50:36Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2025-09-22T09:47:16Z
day: '01'
ddc:
- '576'
- '592'
department:
- _id: SyCr
doi: 10.1002/ece3.2474
external_id:
  isi:
  - '000392063300022'
file:
- access_level: open_access
  checksum: 789026eb9e1be2a0da08376f29f569cf
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:12Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '5062'
  file_name: IST-2017-736-v1+1_Metzler_et_al-2016-Ecology_and_Evolution.pdf
  file_size: 328414
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 8903 - 8906
publication: Ecology and Evolution
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6169'
pubrep_id: '736'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mating and longevity in ant males
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1185'
abstract:
- lang: eng
  text: The developmental programme of the pistil is under the control of both auxin
    and cytokinin. Crosstalk between these factors converges on regulation of the
    auxin carrier PIN-FORMED 1 (PIN1). Here, we show that in the triple transcription
    factor mutant cytokinin response factor 2 (crf2) crf3 crf6 both pistil length
    and ovule number were reduced. PIN1 expression was also lower in the triple mutant
    and the phenotypes could not be rescued by exogenous cytokinin application. pin1
    complementation studies using genomic PIN1 constructs showed that the pistil phenotypes
    were only rescued when the PCRE1 domain, to which CRFs bind, was present. Without
    this domain, pin mutants resemble the crf2 crf3 crf6 triple mutant, indicating
    the pivotal role of CRFs in auxin-cytokinin crosstalk.
acknowledgement: M.C. was funded by a PhD fellowship from the Università degli Studi
  di Milano-Bicocca and from Ministero dell'Istruzione, dell'Università e della Ricerca
  (MIUR) [MIUR-PRIN 2012]. L.C. is also supported by MIUR [MIUR-PRIN 2012]. We would
  like to thank Andrew MacCabe and Edward Kiegle for editing the paper.
article_processing_charge: No
author:
- first_name: Mara
  full_name: Cucinotta, Mara
  last_name: Cucinotta
- first_name: Silvia
  full_name: Manrique, Silvia
  last_name: Manrique
- first_name: Andrea
  full_name: Guazzotti, Andrea
  last_name: Guazzotti
- first_name: Nadia
  full_name: Quadrelli, Nadia
  last_name: Quadrelli
- first_name: Marta
  full_name: Mendes, Marta
  last_name: Mendes
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Lucia
  full_name: Colombo, Lucia
  last_name: Colombo
citation:
  ama: Cucinotta M, Manrique S, Guazzotti A, et al. Cytokinin response factors integrate
    auxin and cytokinin pathways for female reproductive organ development. <i>Development</i>.
    2016;143(23):4419-4424. doi:<a href="https://doi.org/10.1242/dev.143545">10.1242/dev.143545</a>
  apa: Cucinotta, M., Manrique, S., Guazzotti, A., Quadrelli, N., Mendes, M., Benková,
    E., &#38; Colombo, L. (2016). Cytokinin response factors integrate auxin and cytokinin
    pathways for female reproductive organ development. <i>Development</i>. Company
    of Biologists. <a href="https://doi.org/10.1242/dev.143545">https://doi.org/10.1242/dev.143545</a>
  chicago: Cucinotta, Mara, Silvia Manrique, Andrea Guazzotti, Nadia Quadrelli, Marta
    Mendes, Eva Benková, and Lucia Colombo. “Cytokinin Response Factors Integrate
    Auxin and Cytokinin Pathways for Female Reproductive Organ Development.” <i>Development</i>.
    Company of Biologists, 2016. <a href="https://doi.org/10.1242/dev.143545">https://doi.org/10.1242/dev.143545</a>.
  ieee: M. Cucinotta <i>et al.</i>, “Cytokinin response factors integrate auxin and
    cytokinin pathways for female reproductive organ development,” <i>Development</i>,
    vol. 143, no. 23. Company of Biologists, pp. 4419–4424, 2016.
  ista: Cucinotta M, Manrique S, Guazzotti A, Quadrelli N, Mendes M, Benková E, Colombo
    L. 2016. Cytokinin response factors integrate auxin and cytokinin pathways for
    female reproductive organ development. Development. 143(23), 4419–4424.
  mla: Cucinotta, Mara, et al. “Cytokinin Response Factors Integrate Auxin and Cytokinin
    Pathways for Female Reproductive Organ Development.” <i>Development</i>, vol.
    143, no. 23, Company of Biologists, 2016, pp. 4419–24, doi:<a href="https://doi.org/10.1242/dev.143545">10.1242/dev.143545</a>.
  short: M. Cucinotta, S. Manrique, A. Guazzotti, N. Quadrelli, M. Mendes, E. Benková,
    L. Colombo, Development 143 (2016) 4419–4424.
date_created: 2018-12-11T11:50:36Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2025-09-22T09:46:43Z
day: '01'
department:
- _id: EvBe
doi: 10.1242/dev.143545
external_id:
  isi:
  - '000393454100012'
intvolume: '       143'
isi: 1
issue: '23'
language:
- iso: eng
month: '12'
oa_version: None
page: 4419 - 4424
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '6168'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinin response factors integrate auxin and cytokinin pathways for female
  reproductive organ development
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 143
year: '2016'
...
---
_id: '1186'
abstract:
- lang: eng
  text: The human pathogen Streptococcus pneumoniae is decorated with a special class
    of surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine
    (PCho) moieties from cell-wall teichoic acids. By a combination of X-ray crystallography,
    NMR, molecular dynamics techniques and in vivo virulence and phagocytosis studies,
    we provide structural information of choline-binding protein L (CbpL) and demonstrate
    its impact on pneumococcal pathogenesis and immune evasion. CbpL is a very elongated
    three-module protein composed of (i) an Excalibur Ca 2+ -binding domain -reported
    in this work for the very first time-, (ii) an unprecedented anchorage module
    showing alternate disposition of canonical and non-canonical choline-binding sites
    that allows vine-like binding of fully-PCho-substituted teichoic acids (with two
    choline moieties per unit), and (iii) a Ltp-Lipoprotein domain. Our structural
    and infection assays indicate an important role of the whole multimodular protein
    allowing both to locate CbpL at specific places on the cell wall and to interact
    with host components in order to facilitate pneumococcal lung infection and transmigration
    from nasopharynx to the lungs and blood. CbpL implication in both resistance against
    killing by phagocytes and pneumococcal pathogenesis further postulate this surface-protein
    as relevant among the pathogenic arsenal of the pneumococcus.
acknowledgement: We gratefully acknowledge Karsta Barnekow and Kristine Sievert-Giermann,
  for technical assistance and Lothar Petruschka for in silico analysis (all Dept.
  of Genetics, University of Greifswald). We are further grateful to the staff from
  SLS synchrotron beamline for help in data collection. This work was supported by
  grants from the Deutsche Forschungsgemeinschaft DFG GRK 1870 (to SH) and the Spanish
  Ministry of Economy and Competitiveness (BFU2014-59389-P to JAH, CTQ2014-52633-P
  to MB and SAF2012-39760-C02-02 to FG) and S2010/BMD-2457 (Community of Madrid to
  JAH and FG).
article_number: '38094'
article_processing_charge: No
author:
- first_name: Javier
  full_name: Gutierrez-Fernandez, Javier
  id: 3D9511BA-F248-11E8-B48F-1D18A9856A87
  last_name: Gutierrez-Fernandez
- first_name: Malek
  full_name: Saleh, Malek
  last_name: Saleh
- first_name: Martín
  full_name: Alcorlo, Martín
  last_name: Alcorlo
- first_name: Alejandro
  full_name: Gómez Mejóa, Alejandro
  last_name: Gómez Mejóa
- first_name: David
  full_name: Pantoja Uceda, David
  last_name: Pantoja Uceda
- first_name: Miguel
  full_name: Treviño, Miguel
  last_name: Treviño
- first_name: Franziska
  full_name: Vob, Franziska
  last_name: Vob
- first_name: Mohammed
  full_name: Abdullah, Mohammed
  last_name: Abdullah
- first_name: Sergio
  full_name: Galán Bartual, Sergio
  last_name: Galán Bartual
- first_name: Jolien
  full_name: Seinen, Jolien
  last_name: Seinen
- first_name: Pedro
  full_name: Sánchez Murcia, Pedro
  last_name: Sánchez Murcia
- first_name: Federico
  full_name: Gago, Federico
  last_name: Gago
- first_name: Marta
  full_name: Bruix, Marta
  last_name: Bruix
- first_name: Sven
  full_name: Hammerschmidt, Sven
  last_name: Hammerschmidt
- first_name: Juan
  full_name: Hermoso, Juan
  last_name: Hermoso
citation:
  ama: Gutierrez-Fernandez J, Saleh M, Alcorlo M, et al. Modular architecture and
    unique teichoic acid recognition features of choline-binding protein L CbpL contributing
    to pneumococcal pathogenesis. <i>Scientific Reports</i>. 2016;6. doi:<a href="https://doi.org/10.1038/srep38094">10.1038/srep38094</a>
  apa: Gutierrez-Fernandez, J., Saleh, M., Alcorlo, M., Gómez Mejóa, A., Pantoja Uceda,
    D., Treviño, M., … Hermoso, J. (2016). Modular architecture and unique teichoic
    acid recognition features of choline-binding protein L CbpL contributing to pneumococcal
    pathogenesis. <i>Scientific Reports</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/srep38094">https://doi.org/10.1038/srep38094</a>
  chicago: Gutierrez-Fernandez, Javier, Malek Saleh, Martín Alcorlo, Alejandro Gómez
    Mejóa, David Pantoja Uceda, Miguel Treviño, Franziska Vob, et al. “Modular Architecture
    and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L CbpL
    Contributing to Pneumococcal Pathogenesis.” <i>Scientific Reports</i>. Nature
    Publishing Group, 2016. <a href="https://doi.org/10.1038/srep38094">https://doi.org/10.1038/srep38094</a>.
  ieee: J. Gutierrez-Fernandez <i>et al.</i>, “Modular architecture and unique teichoic
    acid recognition features of choline-binding protein L CbpL contributing to pneumococcal
    pathogenesis,” <i>Scientific Reports</i>, vol. 6. Nature Publishing Group, 2016.
  ista: Gutierrez-Fernandez J, Saleh M, Alcorlo M, Gómez Mejóa A, Pantoja Uceda D,
    Treviño M, Vob F, Abdullah M, Galán Bartual S, Seinen J, Sánchez Murcia P, Gago
    F, Bruix M, Hammerschmidt S, Hermoso J. 2016. Modular architecture and unique
    teichoic acid recognition features of choline-binding protein L CbpL contributing
    to pneumococcal pathogenesis. Scientific Reports. 6, 38094.
  mla: Gutierrez-Fernandez, Javier, et al. “Modular Architecture and Unique Teichoic
    Acid Recognition Features of Choline-Binding Protein L CbpL Contributing to Pneumococcal
    Pathogenesis.” <i>Scientific Reports</i>, vol. 6, 38094, Nature Publishing Group,
    2016, doi:<a href="https://doi.org/10.1038/srep38094">10.1038/srep38094</a>.
  short: J. Gutierrez-Fernandez, M. Saleh, M. Alcorlo, A. Gómez Mejóa, D. Pantoja
    Uceda, M. Treviño, F. Vob, M. Abdullah, S. Galán Bartual, J. Seinen, P. Sánchez
    Murcia, F. Gago, M. Bruix, S. Hammerschmidt, J. Hermoso, Scientific Reports 6
    (2016).
date_created: 2018-12-11T11:50:36Z
date_published: 2016-12-05T00:00:00Z
date_updated: 2025-09-22T09:46:12Z
day: '05'
ddc:
- '576'
- '610'
department:
- _id: LeSa
doi: 10.1038/srep38094
external_id:
  isi:
  - '000389129100001'
file:
- access_level: open_access
  checksum: e007d78b483bc59bf5ab98e9d42a6ec1
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:18Z
  date_updated: 2020-07-14T12:44:37Z
  file_id: '4804'
  file_name: IST-2017-735-v1+1_srep38094.pdf
  file_size: 2716045
  relation: main_file
file_date_updated: 2020-07-14T12:44:37Z
has_accepted_license: '1'
intvolume: '         6'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6167'
pubrep_id: '735'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modular architecture and unique teichoic acid recognition features of choline-binding
  protein L CbpL contributing to pneumococcal pathogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 6
year: '2016'
...
---
_id: '1188'
abstract:
- lang: eng
  text: "We consider a population dynamics model coupling cell growth to a diffusion
    in the space of metabolic phenotypes as it can be obtained from realistic constraints-based
    modelling. \r\nIn the asymptotic regime of slow\r\ndiffusion, that coincides with
    the relevant experimental range, the resulting\r\nnon-linear Fokker–Planck equation
    is solved for the steady state in the WKB\r\napproximation that maps it into the
    ground state of a quantum particle in an\r\nAiry potential plus a centrifugal
    term. We retrieve scaling laws for growth rate\r\nfluctuations and time response
    with respect to the distance from the maximum\r\ngrowth rate suggesting that suboptimal
    populations can have a faster response\r\nto perturbations."
acknowledgement: D De Martino is supported by the People Programme (Marie Curie Actions)
  of the European Union's Seventh Framework Programme (FP7/2007–2013) under REA grant
  agreement no. [291734]. D Masoero is supported by the FCT scholarship, number SFRH/BPD/75908/2011.
  D De Martino thanks the Grupo de Física Matemática of the Universidade de Lisboa
  for the kind hospitality. We also wish to thank Matteo Osella, Vincenzo Vitagliano
  and Vera Luz Masoero for useful discussions, also late at night.
article_number: '123502'
article_processing_charge: No
arxiv: 1
author:
- first_name: Daniele
  full_name: De Martino, Daniele
  id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
  last_name: De Martino
  orcid: 0000-0002-5214-4706
- first_name: Davide
  full_name: Masoero, Davide
  last_name: Masoero
citation:
  ama: 'De Martino D, Masoero D. Asymptotic analysis of noisy fitness maximization,
    applied to metabolism &#38;amp; growth. <i> Journal of Statistical Mechanics:
    Theory and Experiment</i>. 2016;2016(12). doi:<a href="https://doi.org/10.1088/1742-5468/aa4e8f">10.1088/1742-5468/aa4e8f</a>'
  apa: 'De Martino, D., &#38; Masoero, D. (2016). Asymptotic analysis of noisy fitness
    maximization, applied to metabolism &#38;amp; growth. <i> Journal of Statistical
    Mechanics: Theory and Experiment</i>. IOP Publishing. <a href="https://doi.org/10.1088/1742-5468/aa4e8f">https://doi.org/10.1088/1742-5468/aa4e8f</a>'
  chicago: 'De Martino, Daniele, and Davide Masoero. “Asymptotic Analysis of Noisy
    Fitness Maximization, Applied to Metabolism &#38;amp; Growth.” <i> Journal of
    Statistical Mechanics: Theory and Experiment</i>. IOP Publishing, 2016. <a href="https://doi.org/10.1088/1742-5468/aa4e8f">https://doi.org/10.1088/1742-5468/aa4e8f</a>.'
  ieee: 'D. De Martino and D. Masoero, “Asymptotic analysis of noisy fitness maximization,
    applied to metabolism &#38;amp; growth,” <i> Journal of Statistical Mechanics:
    Theory and Experiment</i>, vol. 2016, no. 12. IOP Publishing, 2016.'
  ista: 'De Martino D, Masoero D. 2016. Asymptotic analysis of noisy fitness maximization,
    applied to metabolism &#38;amp; growth.  Journal of Statistical Mechanics: Theory
    and Experiment. 2016(12), 123502.'
  mla: 'De Martino, Daniele, and Davide Masoero. “Asymptotic Analysis of Noisy Fitness
    Maximization, Applied to Metabolism &#38;amp; Growth.” <i> Journal of Statistical
    Mechanics: Theory and Experiment</i>, vol. 2016, no. 12, 123502, IOP Publishing,
    2016, doi:<a href="https://doi.org/10.1088/1742-5468/aa4e8f">10.1088/1742-5468/aa4e8f</a>.'
  short: 'D. De Martino, D. Masoero,  Journal of Statistical Mechanics: Theory and
    Experiment 2016 (2016).'
date_created: 2018-12-11T11:50:37Z
date_published: 2016-12-30T00:00:00Z
date_updated: 2025-09-22T09:45:38Z
day: '30'
department:
- _id: GaTk
doi: 10.1088/1742-5468/aa4e8f
ec_funded: 1
external_id:
  arxiv:
  - '1606.09048'
  isi:
  - '000391973900001'
intvolume: '      2016'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1606.09048
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: ' Journal of Statistical Mechanics: Theory and Experiment'
publication_status: published
publisher: IOP Publishing
publist_id: '6165'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Asymptotic analysis of noisy fitness maximization, applied to metabolism &amp;
  growth
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2016
year: '2016'
...
---
_id: '1193'
abstract:
- lang: eng
  text: We consider the recent formulation of the Algorithmic Lovász Local Lemma [1],
    [2] for finding objects that avoid &quot;bad features&quot;, or &quot;flaws&quot;.
    It extends the Moser-Tardos resampling algorithm [3] to more general discrete
    spaces. At each step the method picks a flaw present in the current state and
    &quot;resamples&quot; it using a &quot;resampling oracle&quot; provided by the
    user. However, it is less flexible than the Moser-Tardos method since [1], [2]
    require a specific flaw selection rule, whereas [3] allows an arbitrary rule (and
    thus can potentially be implemented more efficiently). We formulate a new &quot;commutativity&quot;
    condition, and prove that it is sufficient for an arbitrary rule to work. It also
    enables an efficient parallelization under an additional assumption. We then show
    that existing resampling oracles for perfect matchings and permutations do satisfy
    this condition. Finally, we generalize the precondition in [2] (in the case of
    symmetric potential causality graphs). This unifies special cases that previously
    were treated separately.
acknowledgement: European Unions Seventh Framework Programme (FP7/2007-2013)/ERC grant
  agreement no 616160
article_number: '7782993'
article_processing_charge: No
arxiv: 1
author:
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
citation:
  ama: 'Kolmogorov V. Commutativity in the algorithmic Lovasz local lemma. In: <i>Proceedings
    - Annual IEEE Symposium on Foundations of Computer Science</i>. Vol 2016-December.
    IEEE; 2016. doi:<a href="https://doi.org/10.1109/FOCS.2016.88">10.1109/FOCS.2016.88</a>'
  apa: 'Kolmogorov, V. (2016). Commutativity in the algorithmic Lovasz local lemma.
    In <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>
    (Vol. 2016–December). New Brunswick, NJ, USA : IEEE. <a href="https://doi.org/10.1109/FOCS.2016.88">https://doi.org/10.1109/FOCS.2016.88</a>'
  chicago: Kolmogorov, Vladimir. “Commutativity in the Algorithmic Lovasz Local Lemma.”
    In <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>,
    Vol. 2016–December. IEEE, 2016. <a href="https://doi.org/10.1109/FOCS.2016.88">https://doi.org/10.1109/FOCS.2016.88</a>.
  ieee: V. Kolmogorov, “Commutativity in the algorithmic Lovasz local lemma,” in <i>Proceedings
    - Annual IEEE Symposium on Foundations of Computer Science</i>, New Brunswick,
    NJ, USA , 2016, vol. 2016–December.
  ista: 'Kolmogorov V. 2016. Commutativity in the algorithmic Lovasz local lemma.
    Proceedings - Annual IEEE Symposium on Foundations of Computer Science. FOCS:
    Foundations of Computer Science vol. 2016–December, 7782993.'
  mla: Kolmogorov, Vladimir. “Commutativity in the Algorithmic Lovasz Local Lemma.”
    <i>Proceedings - Annual IEEE Symposium on Foundations of Computer Science</i>,
    vol. 2016–December, 7782993, IEEE, 2016, doi:<a href="https://doi.org/10.1109/FOCS.2016.88">10.1109/FOCS.2016.88</a>.
  short: V. Kolmogorov, in:, Proceedings - Annual IEEE Symposium on Foundations of
    Computer Science, IEEE, 2016.
conference:
  end_date: 2016-09-11
  location: 'New Brunswick, NJ, USA '
  name: 'FOCS: Foundations of Computer Science'
  start_date: 2016-09-09
date_created: 2018-12-11T11:50:38Z
date_published: 2016-12-15T00:00:00Z
date_updated: 2025-09-22T09:44:20Z
day: '15'
department:
- _id: VlKo
doi: 10.1109/FOCS.2016.88
ec_funded: 1
external_id:
  arxiv:
  - '1506.08547'
  isi:
  - '000391198500082'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1506.08547v7
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '616160'
  name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: Proceedings - Annual IEEE Symposium on Foundations of Computer Science
publication_status: published
publisher: IEEE
publist_id: '6158'
quality_controlled: '1'
related_material:
  record:
  - id: '5975'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Commutativity in the algorithmic Lovasz local lemma
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2016-December
year: '2016'
...
