---
_id: '5408'
abstract:
- lang: eng
  text: "We consider two-player partial-observation stochastic games where player
    1 has partial observation and player 2 has perfect observation. The winning condition
    we study are omega-regular conditions specified as parity objectives. The qualitative
    analysis problem given a partial-observation stochastic game and a parity objective
    asks whether  there is a strategy to ensure that the objective is satisfied with
    probability 1 (resp. positive probability). While the qualitative analysis problems
    are known to be undecidable even for very special cases of parity objectives,
    they were shown to be decidable in 2EXPTIME under finite-memory  strategies. We
    improve the complexity and show that the qualitative analysis problems for partial-observation
    stochastic parity games under finite-memory strategies are \r\nEXPTIME-complete;
    and also establish optimal (exponential) memory bounds for finite-memory strategies
    required for qualitative analysis. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Sumit
  full_name: Nain, Sumit
  last_name: Nain
- first_name: Moshe
  full_name: Vardi, Moshe
  last_name: Vardi
citation:
  ama: Chatterjee K, Doyen L, Nain S, Vardi M. <i>The Complexity of Partial-Observation
    Stochastic Parity Games with Finite-Memory Strategies</i>. IST Austria; 2013.
    doi:<a href="https://doi.org/10.15479/AT:IST-2013-141-v1-1">10.15479/AT:IST-2013-141-v1-1</a>
  apa: Chatterjee, K., Doyen, L., Nain, S., &#38; Vardi, M. (2013). <i>The complexity
    of partial-observation stochastic parity games with finite-memory strategies</i>.
    IST Austria. <a href="https://doi.org/10.15479/AT:IST-2013-141-v1-1">https://doi.org/10.15479/AT:IST-2013-141-v1-1</a>
  chicago: Chatterjee, Krishnendu, Laurent Doyen, Sumit Nain, and Moshe Vardi. <i>The
    Complexity of Partial-Observation Stochastic Parity Games with Finite-Memory Strategies</i>.
    IST Austria, 2013. <a href="https://doi.org/10.15479/AT:IST-2013-141-v1-1">https://doi.org/10.15479/AT:IST-2013-141-v1-1</a>.
  ieee: K. Chatterjee, L. Doyen, S. Nain, and M. Vardi, <i>The complexity of partial-observation
    stochastic parity games with finite-memory strategies</i>. IST Austria, 2013.
  ista: Chatterjee K, Doyen L, Nain S, Vardi M. 2013. The complexity of partial-observation
    stochastic parity games with finite-memory strategies, IST Austria, 17p.
  mla: Chatterjee, Krishnendu, et al. <i>The Complexity of Partial-Observation Stochastic
    Parity Games with Finite-Memory Strategies</i>. IST Austria, 2013, doi:<a href="https://doi.org/10.15479/AT:IST-2013-141-v1-1">10.15479/AT:IST-2013-141-v1-1</a>.
  short: K. Chatterjee, L. Doyen, S. Nain, M. Vardi, The Complexity of Partial-Observation
    Stochastic Parity Games with Finite-Memory Strategies, IST Austria, 2013.
date_created: 2018-12-12T11:39:10Z
date_published: 2013-09-12T00:00:00Z
date_updated: 2025-04-15T07:56:00Z
day: '12'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2013-141-v1-1
file:
- access_level: open_access
  checksum: 226bc791124f8d3138379778ce834e86
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:53:16Z
  date_updated: 2020-07-14T12:46:46Z
  file_id: '5477'
  file_name: IST-2013-141-v1+1_main-tech-rpt.pdf
  file_size: 300481
  relation: main_file
file_date_updated: 2020-07-14T12:46:46Z
fulldoi: https://doi.org/10.15479/AT:IST-2013-141-v1-1
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '17'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '141'
related_material:
  record:
  - id: '2213'
    relation: later_version
    status: public
status: public
title: The complexity of partial-observation stochastic parity games with finite-memory
  strategies
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '5409'
abstract:
- lang: eng
  text: "The edit distance between two (untimed) traces is the minimum cost of a sequence
    of edit operations (insertion, deletion, or substitution) needed to transform
    one trace to the other. Edit distances have been extensively studied in the untimed
    setting, and form the basis for approximate matching of sequences in different
    domains such as coding theory, parsing, and speech recognition. \r\nIn this paper,
    we lift the study of edit distances from untimed languages to the timed setting.
    We define an edit distance between timed words which incorporates both the edit
    distance between the untimed words and the absolute difference in timestamps.
    Our edit distance between two timed words is computable in polynomial time. Further,
    we show that the edit distance between a timed word and a timed language generated
    by a timed automaton, defined as the edit distance between the word and the closest
    word in the language, is PSPACE-complete. While computing the edit distance between
    two timed automata is undecidable, we show that the approximate version, where
    we decide if the edit distance between two timed automata is either less than
    a given parameter or more than delta away from the parameter, for delta>0, can
    be solved in exponential space and is EXPSPACE-hard. Our definitions and techniques
    can be generalized to the setting of hybrid systems, and we show analogous decidability
    results for rectangular automata."
alternative_title:
- IST Austria Technical Report
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Rupak
  full_name: Majumdar, Rupak
  last_name: Majumdar
citation:
  ama: Chatterjee K, Ibsen-Jensen R, Majumdar R. <i>Edit Distance for Timed Automata</i>.
    IST Austria; 2013. doi:<a href="https://doi.org/10.15479/AT:IST-2013-144-v1-1">10.15479/AT:IST-2013-144-v1-1</a>
  apa: Chatterjee, K., Ibsen-Jensen, R., &#38; Majumdar, R. (2013). <i>Edit distance
    for timed automata</i>. IST Austria. <a href="https://doi.org/10.15479/AT:IST-2013-144-v1-1">https://doi.org/10.15479/AT:IST-2013-144-v1-1</a>
  chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Rupak Majumdar. <i>Edit
    Distance for Timed Automata</i>. IST Austria, 2013. <a href="https://doi.org/10.15479/AT:IST-2013-144-v1-1">https://doi.org/10.15479/AT:IST-2013-144-v1-1</a>.
  ieee: K. Chatterjee, R. Ibsen-Jensen, and R. Majumdar, <i>Edit distance for timed
    automata</i>. IST Austria, 2013.
  ista: Chatterjee K, Ibsen-Jensen R, Majumdar R. 2013. Edit distance for timed automata,
    IST Austria, 12p.
  mla: Chatterjee, Krishnendu, et al. <i>Edit Distance for Timed Automata</i>. IST
    Austria, 2013, doi:<a href="https://doi.org/10.15479/AT:IST-2013-144-v1-1">10.15479/AT:IST-2013-144-v1-1</a>.
  short: K. Chatterjee, R. Ibsen-Jensen, R. Majumdar, Edit Distance for Timed Automata,
    IST Austria, 2013.
date_created: 2018-12-12T11:39:10Z
date_published: 2013-10-30T00:00:00Z
date_updated: 2024-10-21T06:02:53Z
day: '30'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2013-144-v1-1
file:
- access_level: open_access
  checksum: 0f7633081ba8299c543322f0ad08571f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:53:08Z
  date_updated: 2020-07-14T12:46:46Z
  file_id: '5469'
  file_name: IST-2013-144-v1+1_main.pdf
  file_size: 336377
  relation: main_file
file_date_updated: 2020-07-14T12:46:46Z
fulldoi: https://doi.org/10.15479/AT:IST-2013-144-v1-1
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '12'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '144'
related_material:
  record:
  - id: '2216'
    relation: later_version
    status: public
status: public
title: Edit distance for timed automata
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '5410'
abstract:
- lang: eng
  text: "Board games, like Tic-Tac-Toe and CONNECT-4, play an important role not only
    in development of mathematical and logical skills, but also in emotional and social
    development. In this paper, we address the problem of generating targeted starting
    positions for such games. This can facilitate new approaches for bringing novice
    players to mastery, and also leads to discovery of interesting game variants.
    \r\nOur approach generates starting states of varying hardness levels for player
    1 in a two-player board game, given rules of the board game, the desired number
    of steps required for player 1 to win, and the expertise levels of the two players.
    Our approach leverages symbolic methods and iterative simulation to efficiently
    search the extremely large state space. We present experimental results that include
    discovery of states of varying hardness levels for several simple grid-based board
    games. Also, the presence of such states for standard game variants like Tic-Tac-Toe
    on board size 4x4 opens up new games to be played that have not been played for
    ages since the default start state is heavily biased. "
alternative_title:
- IST Austria Technical Report
author:
- first_name: Umair
  full_name: Ahmed, Umair
  last_name: Ahmed
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Sumit
  full_name: Gulwani, Sumit
  last_name: Gulwani
citation:
  ama: Ahmed U, Chatterjee K, Gulwani S. <i>Automatic Generation of Alternative Starting
    Positions for Traditional Board Games</i>. IST Austria; 2013. doi:<a href="https://doi.org/10.15479/AT:IST-2013-146-v1-1">10.15479/AT:IST-2013-146-v1-1</a>
  apa: Ahmed, U., Chatterjee, K., &#38; Gulwani, S. (2013). <i>Automatic generation
    of alternative starting positions for traditional board games</i>. IST Austria.
    <a href="https://doi.org/10.15479/AT:IST-2013-146-v1-1">https://doi.org/10.15479/AT:IST-2013-146-v1-1</a>
  chicago: Ahmed, Umair, Krishnendu Chatterjee, and Sumit Gulwani. <i>Automatic Generation
    of Alternative Starting Positions for Traditional Board Games</i>. IST Austria,
    2013. <a href="https://doi.org/10.15479/AT:IST-2013-146-v1-1">https://doi.org/10.15479/AT:IST-2013-146-v1-1</a>.
  ieee: U. Ahmed, K. Chatterjee, and S. Gulwani, <i>Automatic generation of alternative
    starting positions for traditional board games</i>. IST Austria, 2013.
  ista: Ahmed U, Chatterjee K, Gulwani S. 2013. Automatic generation of alternative
    starting positions for traditional board games, IST Austria, 13p.
  mla: Ahmed, Umair, et al. <i>Automatic Generation of Alternative Starting Positions
    for Traditional Board Games</i>. IST Austria, 2013, doi:<a href="https://doi.org/10.15479/AT:IST-2013-146-v1-1">10.15479/AT:IST-2013-146-v1-1</a>.
  short: U. Ahmed, K. Chatterjee, S. Gulwani, Automatic Generation of Alternative
    Starting Positions for Traditional Board Games, IST Austria, 2013.
date_created: 2018-12-12T11:39:10Z
date_published: 2013-12-03T00:00:00Z
date_updated: 2025-05-19T11:10:16Z
day: '03'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.15479/AT:IST-2013-146-v1-1
file:
- access_level: open_access
  checksum: 409f3aaaf1184e4057b89cbb449dac80
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T11:54:06Z
  date_updated: 2020-07-14T12:46:46Z
  file_id: '5528'
  file_name: IST-2013-146-v1+1_main.pdf
  file_size: 818189
  relation: main_file
file_date_updated: 2020-07-14T12:46:46Z
fulldoi: https://doi.org/10.15479/AT:IST-2013-146-v1-1
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '13'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '146'
related_material:
  record:
  - id: '1481'
    relation: later_version
    status: public
status: public
title: Automatic generation of alternative starting positions for traditional board
  games
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '5747'
article_processing_charge: No
author:
- first_name: Cezara
  full_name: Dragoi, Cezara
  id: 2B2B5ED0-F248-11E8-B48F-1D18A9856A87
  last_name: Dragoi
- first_name: Ashutosh
  full_name: Gupta, Ashutosh
  id: 335E5684-F248-11E8-B48F-1D18A9856A87
  last_name: Gupta
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Dragoi C, Gupta A, Henzinger TA. Automatic Linearizability Proofs of Concurrent
    Objects with Cooperating Updates. In: <i>Computer Aided Verification</i>. Vol
    8044. CAV. Berlin, Heidelberg: Springer Berlin Heidelberg; 2013:174-190. doi:<a
    href="https://doi.org/10.1007/978-3-642-39799-8_11">10.1007/978-3-642-39799-8_11</a>'
  apa: 'Dragoi, C., Gupta, A., &#38; Henzinger, T. A. (2013). Automatic Linearizability
    Proofs of Concurrent Objects with Cooperating Updates. In <i>Computer Aided Verification</i>
    (Vol. 8044, pp. 174–190). Berlin, Heidelberg: Springer Berlin Heidelberg. <a href="https://doi.org/10.1007/978-3-642-39799-8_11">https://doi.org/10.1007/978-3-642-39799-8_11</a>'
  chicago: 'Dragoi, Cezara, Ashutosh Gupta, and Thomas A Henzinger. “Automatic Linearizability
    Proofs of Concurrent Objects with Cooperating Updates.” In <i>Computer Aided Verification</i>,
    8044:174–90. CAV. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. <a href="https://doi.org/10.1007/978-3-642-39799-8_11">https://doi.org/10.1007/978-3-642-39799-8_11</a>.'
  ieee: 'C. Dragoi, A. Gupta, and T. A. Henzinger, “Automatic Linearizability Proofs
    of Concurrent Objects with Cooperating Updates,” in <i>Computer Aided Verification</i>,
    vol. 8044, Berlin, Heidelberg: Springer Berlin Heidelberg, 2013, pp. 174–190.'
  ista: 'Dragoi C, Gupta A, Henzinger TA. 2013.Automatic Linearizability Proofs of
    Concurrent Objects with Cooperating Updates. In: Computer Aided Verification.
    vol. 8044, 174–190.'
  mla: Dragoi, Cezara, et al. “Automatic Linearizability Proofs of Concurrent Objects
    with Cooperating Updates.” <i>Computer Aided Verification</i>, vol. 8044, Springer
    Berlin Heidelberg, 2013, pp. 174–90, doi:<a href="https://doi.org/10.1007/978-3-642-39799-8_11">10.1007/978-3-642-39799-8_11</a>.
  short: C. Dragoi, A. Gupta, T.A. Henzinger, in:, Computer Aided Verification, Springer
    Berlin Heidelberg, Berlin, Heidelberg, 2013, pp. 174–190.
conference:
  end_date: 2013-07-19
  location: Saint Petersburg, Russia
  name: 'CAV: Computer Aided Verification'
  start_date: 2013-07-13
date_created: 2018-12-18T13:10:21Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2025-07-10T11:52:57Z
day: '01'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.1007/978-3-642-39799-8_11
ec_funded: 1
file:
- access_level: open_access
  checksum: a901cc6b71db08b61c0d4c0cbacc6287
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T13:13:33Z
  date_updated: 2020-07-14T12:47:10Z
  file_id: '5748'
  file_name: 2013_CAV_Dragoi.pdf
  file_size: 236480
  relation: main_file
file_date_updated: 2020-07-14T12:47:10Z
fulldoi: https://doi.org/10.1007/978-3-642-39799-8_11
has_accepted_license: '1'
intvolume: '      8044'
language:
- iso: eng
month: '08'
oa: 1
oa_version: None
page: 174-190
place: Berlin, Heidelberg
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication: Computer Aided Verification
publication_identifier:
  eisbn:
  - '9783642397998'
  eissn:
  - 1611-3349
  isbn:
  - '9783642397981'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Berlin Heidelberg
pubrep_id: '195'
quality_controlled: '1'
scopus_import: '1'
series_title: CAV
status: public
title: Automatic Linearizability Proofs of Concurrent Objects with Cooperating Updates
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8044
year: '2013'
...
---
OA_place: repository
OA_type: green
_id: '19995'
abstract:
- lang: eng
  text: Markov decision processes (MDPs) and simple stochastic games (SSGs) provide
    a rich mathematical framework to study many important problems related to probabilistic
    systems. MDPs and SSGs with finite-horizon objectives, where the goal is to maximize
    the probability to reach a target state in a given finite time, is a classical
    and well-studied problem. In this work we consider the strategy complexity of
    finite-horizon MDPs and SSGs. We show that for all ε > 0, the natural class of
    counter-based strategies require at most log log/(1/ε) + n + 1 memory states,
    and memory of size Omega(log log(1/ε) + n) is required, for ε-optimality, where
    n is the number of states of the MDP (resp. SSG). Thus our bounds are asymptotically
    optimal. We then study the periodic property of optimal strategies, and show a
    sub-exponential lower bound on the period for optimal strategies.
acknowledgement: 'Work of the second author supported by the Sino-Danish Center for
  the Theory of Interactive Computation, funded by the Danish National Research Foundation
  and the National Science Foundation of China (under the grant 61061130540). The
  second author acknowledge support from the Center for research in the Foundations
  of Electronic Markets (CFEM), supported by the Danish Strategic Research Council.
  The first author was supported by FWF Grant No P 23499-N23, FWF NFN Grant No S11407-N23
  (RiSE), ERC Start grant (279307: Graph Games), and Microsoft faculty fellows award.'
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
citation:
  ama: 'Chatterjee K, Ibsen-Jensen R. Strategy complexity of finite-horizon Markov
    decision processes and simple stochastic games. In: <i>Mathematical and Engineering
    Methods in Computer Science</i>. Vol 7721. Springer Nature; 2013:106-117. doi:<a
    href="https://doi.org/10.1007/978-3-642-36046-6_11">10.1007/978-3-642-36046-6_11</a>'
  apa: 'Chatterjee, K., &#38; Ibsen-Jensen, R. (2013). Strategy complexity of finite-horizon
    Markov decision processes and simple stochastic games. In <i>Mathematical and
    Engineering Methods in Computer Science</i> (Vol. 7721, pp. 106–117). Znojmo,
    Czech Republic: Springer Nature. <a href="https://doi.org/10.1007/978-3-642-36046-6_11">https://doi.org/10.1007/978-3-642-36046-6_11</a>'
  chicago: Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “Strategy Complexity of
    Finite-Horizon Markov Decision Processes and Simple Stochastic Games.” In <i>Mathematical
    and Engineering Methods in Computer Science</i>, 7721:106–17. Springer Nature,
    2013. <a href="https://doi.org/10.1007/978-3-642-36046-6_11">https://doi.org/10.1007/978-3-642-36046-6_11</a>.
  ieee: K. Chatterjee and R. Ibsen-Jensen, “Strategy complexity of finite-horizon
    Markov decision processes and simple stochastic games,” in <i>Mathematical and
    Engineering Methods in Computer Science</i>, Znojmo, Czech Republic, 2013, vol.
    7721, pp. 106–117.
  ista: 'Chatterjee K, Ibsen-Jensen R. 2013. Strategy complexity of finite-horizon
    Markov decision processes and simple stochastic games. Mathematical and Engineering
    Methods in Computer Science. MEMICS: Mathematical and Engineering Methods in Computer
    Science, LNCS, vol. 7721, 106–117.'
  mla: Chatterjee, Krishnendu, and Rasmus Ibsen-Jensen. “Strategy Complexity of Finite-Horizon
    Markov Decision Processes and Simple Stochastic Games.” <i>Mathematical and Engineering
    Methods in Computer Science</i>, vol. 7721, Springer Nature, 2013, pp. 106–17,
    doi:<a href="https://doi.org/10.1007/978-3-642-36046-6_11">10.1007/978-3-642-36046-6_11</a>.
  short: K. Chatterjee, R. Ibsen-Jensen, in:, Mathematical and Engineering Methods
    in Computer Science, Springer Nature, 2013, pp. 106–117.
conference:
  end_date: 2012-10-28
  location: Znojmo, Czech Republic
  name: 'MEMICS: Mathematical and Engineering Methods in Computer Science'
  start_date: 2012-10-25
corr_author: '1'
date_created: 2025-07-10T14:08:49Z
date_published: 2013-01-17T00:00:00Z
date_updated: 2025-09-23T09:24:13Z
day: '17'
department:
- _id: KrCh
doi: 10.1007/978-3-642-36046-6_11
ec_funded: 1
external_id:
  arxiv:
  - '1209.3617'
fulldoi: https://doi.org/10.1007/978-3-642-36046-6_11
intvolume: '      7721'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.1209.3617
month: '01'
oa: 1
oa_version: Preprint
page: 106-117
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication: Mathematical and Engineering Methods in Computer Science
publication_identifier:
  eisbn:
  - '9783642360466'
  eissn:
  - 1611-3349
  isbn:
  - '9783642360442'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Strategy complexity of finite-horizon Markov decision processes and simple
  stochastic games
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7721
year: '2013'
...
---
_id: '2009'
abstract:
- lang: eng
  text: Traditional statistical methods for confidentiality protection of statistical
    databases do not scale well to deal with GWAS databases especially in terms of
    guarantees regarding protection from linkage to external information. The more
    recent concept of differential privacy, introduced by the cryptographic community,
    is an approach which provides a rigorous definition of privacy with meaningful
    privacy guarantees in the presence of arbitrary external information, although
    the guarantees may come at a serious price in terms of data utility. Building
    on such notions, we propose new methods to release aggregate GWAS data without
    compromising an individual’s privacy. We present methods for releasing differentially
    private minor allele frequencies, chi-square statistics and p-values. We compare
    these approaches on simulated data and on a GWAS study of canine hair length involving
    685 dogs. We also propose a privacy-preserving method for finding genome-wide
    associations based on a differentially-private approach to penalized logistic
    regression.
article_processing_charge: No
author:
- first_name: Caroline
  full_name: Uhler, Caroline
  id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
  last_name: Uhler
  orcid: 0000-0002-7008-0216
- first_name: Aleksandra
  full_name: Slavkovic, Aleksandra
  last_name: Slavkovic
- first_name: Stephen
  full_name: Fienberg, Stephen
  last_name: Fienberg
citation:
  ama: Uhler C, Slavkovic A, Fienberg S. Privacy-preserving data sharing for genome-wide
    association studies. <i>Journal of Privacy and Confidentiality </i>. 2013;5(1):137-166.
    doi:<a href="https://doi.org/10.29012/jpc.v5i1.629">10.29012/jpc.v5i1.629</a>
  apa: Uhler, C., Slavkovic, A., &#38; Fienberg, S. (2013). Privacy-preserving data
    sharing for genome-wide association studies. <i>Journal of Privacy and Confidentiality
    </i>. Carnegie Mellon University. <a href="https://doi.org/10.29012/jpc.v5i1.629">https://doi.org/10.29012/jpc.v5i1.629</a>
  chicago: Uhler, Caroline, Aleksandra Slavkovic, and Stephen Fienberg. “Privacy-Preserving
    Data Sharing for Genome-Wide Association Studies.” <i>Journal of Privacy and Confidentiality
    </i>. Carnegie Mellon University, 2013. <a href="https://doi.org/10.29012/jpc.v5i1.629">https://doi.org/10.29012/jpc.v5i1.629</a>.
  ieee: C. Uhler, A. Slavkovic, and S. Fienberg, “Privacy-preserving data sharing
    for genome-wide association studies,” <i>Journal of Privacy and Confidentiality
    </i>, vol. 5, no. 1. Carnegie Mellon University, pp. 137–166, 2013.
  ista: Uhler C, Slavkovic A, Fienberg S. 2013. Privacy-preserving data sharing for
    genome-wide association studies. Journal of Privacy and Confidentiality . 5(1),
    137–166.
  mla: Uhler, Caroline, et al. “Privacy-Preserving Data Sharing for Genome-Wide Association
    Studies.” <i>Journal of Privacy and Confidentiality </i>, vol. 5, no. 1, Carnegie
    Mellon University, 2013, pp. 137–66, doi:<a href="https://doi.org/10.29012/jpc.v5i1.629">10.29012/jpc.v5i1.629</a>.
  short: C. Uhler, A. Slavkovic, S. Fienberg, Journal of Privacy and Confidentiality  5
    (2013) 137–166.
date_created: 2018-12-11T11:55:11Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2026-06-18T18:20:21Z
day: '01'
ddc:
- '000'
department:
- _id: CaUh
doi: 10.29012/jpc.v5i1.629
fulldoi: https://doi.org/10.29012/jpc.v5i1.629
intvolume: '         5'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://repository.cmu.edu/jpc/vol5/iss1/6
month: '08'
oa: 1
oa_version: Published Version
page: 137 - 166
publication: 'Journal of Privacy and Confidentiality '
publication_status: published
publisher: Carnegie Mellon University
publist_id: '5067'
quality_controlled: '1'
status: public
title: Privacy-preserving data sharing for genome-wide association studies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2013'
...
---
_id: '2010'
abstract:
- lang: eng
  text: Many algorithms for inferring causality rely heavily on the faithfulness assumption.
    The main justification for imposing this assumption is that the set of unfaithful
    distributions has Lebesgue measure zero, since it can be seen as a collection
    of hypersurfaces in a hypercube. However, due to sampling error the faithfulness
    condition alone is not sufficient for statistical estimation, and strong-faithfulness
    has been proposed and assumed to achieve uniform or high-dimensional consistency.
    In contrast to the plain faithfulness assumption, the set of distributions that
    is not strong-faithful has nonzero Lebesgue measure and in fact, can be surprisingly
    large as we show in this paper. We study the strong-faithfulness condition from
    a geometric and combinatorial point of view and give upper and lower bounds on
    the Lebesgue measure of strong-faithful distributions for various classes of directed
    acyclic graphs. Our results imply fundamental limitations for the PC-algorithm
    and potentially also for other algorithms based on partial correlation testing
    in the Gaussian case.
article_processing_charge: No
arxiv: 1
author:
- first_name: Caroline
  full_name: Uhler, Caroline
  id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
  last_name: Uhler
  orcid: 0000-0002-7008-0216
- first_name: Garvesh
  full_name: Raskutti, Garvesh
  last_name: Raskutti
- first_name: Peter
  full_name: Bühlmann, Peter
  last_name: Bühlmann
- first_name: Bin
  full_name: Yu, Bin
  last_name: Yu
citation:
  ama: Uhler C, Raskutti G, Bühlmann P, Yu B. Geometry of the faithfulness assumption
    in causal inference. <i>The Annals of Statistics</i>. 2013;41(2):436-463. doi:<a
    href="https://doi.org/10.1214/12-AOS1080">10.1214/12-AOS1080</a>
  apa: Uhler, C., Raskutti, G., Bühlmann, P., &#38; Yu, B. (2013). Geometry of the
    faithfulness assumption in causal inference. <i>The Annals of Statistics</i>.
    Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/12-AOS1080">https://doi.org/10.1214/12-AOS1080</a>
  chicago: Uhler, Caroline, Garvesh Raskutti, Peter Bühlmann, and Bin Yu. “Geometry
    of the Faithfulness Assumption in Causal Inference.” <i>The Annals of Statistics</i>.
    Institute of Mathematical Statistics, 2013. <a href="https://doi.org/10.1214/12-AOS1080">https://doi.org/10.1214/12-AOS1080</a>.
  ieee: C. Uhler, G. Raskutti, P. Bühlmann, and B. Yu, “Geometry of the faithfulness
    assumption in causal inference,” <i>The Annals of Statistics</i>, vol. 41, no.
    2. Institute of Mathematical Statistics, pp. 436–463, 2013.
  ista: Uhler C, Raskutti G, Bühlmann P, Yu B. 2013. Geometry of the faithfulness
    assumption in causal inference. The Annals of Statistics. 41(2), 436–463.
  mla: Uhler, Caroline, et al. “Geometry of the Faithfulness Assumption in Causal
    Inference.” <i>The Annals of Statistics</i>, vol. 41, no. 2, Institute of Mathematical
    Statistics, 2013, pp. 436–63, doi:<a href="https://doi.org/10.1214/12-AOS1080">10.1214/12-AOS1080</a>.
  short: C. Uhler, G. Raskutti, P. Bühlmann, B. Yu, The Annals of Statistics 41 (2013)
    436–463.
date_created: 2018-12-11T11:55:11Z
date_published: 2013-04-01T00:00:00Z
date_updated: 2026-06-18T18:20:45Z
day: '01'
ddc:
- '500'
department:
- _id: CaUh
doi: 10.1214/12-AOS1080
external_id:
  arxiv:
  - '1207.0547'
  isi:
  - '000320488200002'
fulldoi: https://doi.org/10.1214/12-AOS1080
intvolume: '        41'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: www.doi.org/10.1214/12-AOS1080
month: '04'
oa: 1
oa_version: Published Version
page: 436 - 463
publication: The Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5066'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry of the faithfulness assumption in causal inference
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2013'
...
---
_id: '10396'
abstract:
- lang: eng
  text: Stimfit is a free cross-platform software package for viewing and analyzing
    electrophysiological data. It supports most standard file types for cellular neurophysiology
    and other biomedical formats. Its analysis algorithms have been used and validated
    in several experimental laboratories. Its embedded Python scripting interface
    makes Stimfit highly extensible and customizable.
article_number: '000010151520134181'
article_processing_charge: No
article_type: original
author:
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: C.
  full_name: Schmidt-Hieber, C.
  last_name: Schmidt-Hieber
- first_name: S. J.
  full_name: Guzman, S. J.
  last_name: Guzman
citation:
  ama: 'Schlögl A, Jonas PM, Schmidt-Hieber C, Guzman SJ. Stimfit: A fast visualization
    and analysis environment for cellular neurophysiology. <i>Biomedical Engineering
    / Biomedizinische Technik</i>. 2013;58(SI-1-Track-G). doi:<a href="https://doi.org/10.1515/bmt-2013-4181">10.1515/bmt-2013-4181</a>'
  apa: 'Schlögl, A., Jonas, P. M., Schmidt-Hieber, C., &#38; Guzman, S. J. (2013).
    Stimfit: A fast visualization and analysis environment for cellular neurophysiology.
    <i>Biomedical Engineering / Biomedizinische Technik</i>. Graz, Austria: De Gruyter.
    <a href="https://doi.org/10.1515/bmt-2013-4181">https://doi.org/10.1515/bmt-2013-4181</a>'
  chicago: 'Schlögl, Alois, Peter M Jonas, C. Schmidt-Hieber, and S. J. Guzman. “Stimfit:
    A Fast Visualization and Analysis Environment for Cellular Neurophysiology.” <i>Biomedical
    Engineering / Biomedizinische Technik</i>. De Gruyter, 2013. <a href="https://doi.org/10.1515/bmt-2013-4181">https://doi.org/10.1515/bmt-2013-4181</a>.'
  ieee: 'A. Schlögl, P. M. Jonas, C. Schmidt-Hieber, and S. J. Guzman, “Stimfit: A
    fast visualization and analysis environment for cellular neurophysiology,” <i>Biomedical
    Engineering / Biomedizinische Technik</i>, vol. 58, no. SI-1-Track-G. De Gruyter,
    2013.'
  ista: 'Schlögl A, Jonas PM, Schmidt-Hieber C, Guzman SJ. 2013. Stimfit: A fast visualization
    and analysis environment for cellular neurophysiology. Biomedical Engineering
    / Biomedizinische Technik. 58(SI-1-Track-G), 000010151520134181.'
  mla: 'Schlögl, Alois, et al. “Stimfit: A Fast Visualization and Analysis Environment
    for Cellular Neurophysiology.” <i>Biomedical Engineering / Biomedizinische Technik</i>,
    vol. 58, no. SI-1-Track-G, 000010151520134181, De Gruyter, 2013, doi:<a href="https://doi.org/10.1515/bmt-2013-4181">10.1515/bmt-2013-4181</a>.'
  short: A. Schlögl, P.M. Jonas, C. Schmidt-Hieber, S.J. Guzman, Biomedical Engineering
    / Biomedizinische Technik 58 (2013).
conference:
  end_date: 2013-09-21
  location: Graz, Austria
  name: 'BMT: Biomedizinische Technik '
  start_date: 2013-09-19
corr_author: '1'
date_created: 2021-12-01T14:35:35Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2025-09-30T07:31:23Z
day: '01'
ddc:
- '005'
- '610'
department:
- _id: PeJo
doi: 10.1515/bmt-2013-4181
external_id:
  isi:
  - '000497714000034'
  pmid:
  - '24042795'
file:
- access_level: open_access
  checksum: cdfc5339b530a25d6079f7223f0b1f16
  content_type: application/pdf
  creator: schloegl
  date_created: 2021-12-01T14:38:08Z
  date_updated: 2021-12-01T14:38:08Z
  file_id: '10397'
  file_name: Schloegl_Abstract-BMT2013.pdf
  file_size: 149825
  relation: main_file
  success: 1
file_date_updated: 2021-12-01T14:38:08Z
fulldoi: https://doi.org/10.1515/bmt-2013-4181
has_accepted_license: '1'
intvolume: '        58'
isi: 1
issue: SI-1-Track-G
keyword:
- biomedical engineering
- data analysis
- free software
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Biomedical Engineering / Biomedizinische Technik
publication_identifier:
  eissn:
  - 1862-278X
  issn:
  - 0013-5585
publication_status: published
publisher: De Gruyter
quality_controlled: '1'
status: public
title: 'Stimfit: A fast visualization and analysis environment for cellular neurophysiology'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 58
year: '2013'
...
---
_id: '827'
abstract:
- lang: eng
  text: As sessile organisms, plants have to be able to adapt to a continuously changing
    environment. Plants that perceive some of these changes as stress signals activate
    signaling pathways to modulate their development and to enable them to survive.
    The complex responses to environmental cues are to a large extent mediated by
    plant hormones that together orchestrate the final plant response. The phytohormone
    cytokinin is involved in many plant developmental processes. Recently, it has
    been established that cytokinin plays an important role in stress responses, but
    does not act alone. Indeed, the hormonal control of plant development and stress
    adaptation is the outcome of a complex network of multiple synergistic and antagonistic
    interactions between various hormones. Here, we review the recent findings on
    the cytokinin function as part of this hormonal network. We focus on the importance
    of the crosstalk between cytokinin and other hormones, such as abscisic acid,
    jasmonate, salicylic acid, ethylene, and auxin in the modulation of plant development
    and stress adaptation. Finally, the impact of the current research in the biotechnological
    industry will be discussed.
article_number: '451'
article_processing_charge: No
author:
- first_name: José
  full_name: O'Brien, José
  last_name: O'Brien
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: O’Brien J, Benková E. Cytokinin cross talking during biotic and abiotic stress
    responses. <i>Frontiers in Plant Science</i>. 2013;4. doi:<a href="https://doi.org/10.3389/fpls.2013.00451">10.3389/fpls.2013.00451</a>
  apa: O’Brien, J., &#38; Benková, E. (2013). Cytokinin cross talking during biotic
    and abiotic stress responses. <i>Frontiers in Plant Science</i>. Frontiers Research
    Foundation. <a href="https://doi.org/10.3389/fpls.2013.00451">https://doi.org/10.3389/fpls.2013.00451</a>
  chicago: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic
    and Abiotic Stress Responses.” <i>Frontiers in Plant Science</i>. Frontiers Research
    Foundation, 2013. <a href="https://doi.org/10.3389/fpls.2013.00451">https://doi.org/10.3389/fpls.2013.00451</a>.
  ieee: J. O’Brien and E. Benková, “Cytokinin cross talking during biotic and abiotic
    stress responses,” <i>Frontiers in Plant Science</i>, vol. 4. Frontiers Research
    Foundation, 2013.
  ista: O’Brien J, Benková E. 2013. Cytokinin cross talking during biotic and abiotic
    stress responses. Frontiers in Plant Science. 4, 451.
  mla: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic and
    Abiotic Stress Responses.” <i>Frontiers in Plant Science</i>, vol. 4, 451, Frontiers
    Research Foundation, 2013, doi:<a href="https://doi.org/10.3389/fpls.2013.00451">10.3389/fpls.2013.00451</a>.
  short: J. O’Brien, E. Benková, Frontiers in Plant Science 4 (2013).
corr_author: '1'
date_created: 2018-12-11T11:48:43Z
date_published: 2013-11-19T00:00:00Z
date_updated: 2025-09-29T14:33:09Z
day: '19'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00451
ec_funded: 1
external_id:
  isi:
  - '000331445200001'
file:
- access_level: open_access
  checksum: fdc25ddd1bf9a99b99f662cdbafeddd4
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-31T10:40:38Z
  date_updated: 2020-07-14T12:48:11Z
  file_id: '5903'
  file_name: 2013_FrontiersPlant_OBrien.pdf
  file_size: 953299
  relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
fulldoi: https://doi.org/10.3389/fpls.2013.00451
has_accepted_license: '1'
intvolume: '         4'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6821'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinin cross talking during biotic and abiotic stress responses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 4
year: '2013'
...
---
_id: '828'
abstract:
- lang: eng
  text: The plant root system is essential for providing anchorage to the soil, supplying
    minerals and water, and synthesizing metabolites. It is a dynamic organ modulated
    by external cues such as environmental signals, water and nutrients availability,
    salinity and others. Lateral roots (LRs) are initiated from the primary root post-embryonically,
    after which they progress through discrete developmental stages which can be independently
    controlled, providing a high level of plasticity during root system formation.
    Within this review, main contributions are presented, from the classical forward
    genetic screens to the more recent high-throughput approaches, combined with computer
    model predictions, dissecting how LRs and thereby root system architecture is
    established and developed.
article_number: '537'
article_processing_charge: No
author:
- first_name: Candela
  full_name: Cuesta, Candela
  id: 33A3C818-F248-11E8-B48F-1D18A9856A87
  last_name: Cuesta
  orcid: 0000-0003-1923-2410
- first_name: Krzysztof T
  full_name: Wabnik, Krzysztof T
  id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
  last_name: Wabnik
  orcid: 0000-0001-7263-0560
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Cuesta C, Wabnik KT, Benková E. Systems approaches to study root architecture
    dynamics. <i>Frontiers in Plant Science</i>. 2013;4. doi:<a href="https://doi.org/10.3389/fpls.2013.00537">10.3389/fpls.2013.00537</a>
  apa: Cuesta, C., Wabnik, K. T., &#38; Benková, E. (2013). Systems approaches to
    study root architecture dynamics. <i>Frontiers in Plant Science</i>. Frontiers
    Research Foundation. <a href="https://doi.org/10.3389/fpls.2013.00537">https://doi.org/10.3389/fpls.2013.00537</a>
  chicago: Cuesta, Candela, Krzysztof T Wabnik, and Eva Benková. “Systems Approaches
    to Study Root Architecture Dynamics.” <i>Frontiers in Plant Science</i>. Frontiers
    Research Foundation, 2013. <a href="https://doi.org/10.3389/fpls.2013.00537">https://doi.org/10.3389/fpls.2013.00537</a>.
  ieee: C. Cuesta, K. T. Wabnik, and E. Benková, “Systems approaches to study root
    architecture dynamics,” <i>Frontiers in Plant Science</i>, vol. 4. Frontiers Research
    Foundation, 2013.
  ista: Cuesta C, Wabnik KT, Benková E. 2013. Systems approaches to study root architecture
    dynamics. Frontiers in Plant Science. 4, 537.
  mla: Cuesta, Candela, et al. “Systems Approaches to Study Root Architecture Dynamics.”
    <i>Frontiers in Plant Science</i>, vol. 4, 537, Frontiers Research Foundation,
    2013, doi:<a href="https://doi.org/10.3389/fpls.2013.00537">10.3389/fpls.2013.00537</a>.
  short: C. Cuesta, K.T. Wabnik, E. Benková, Frontiers in Plant Science 4 (2013).
corr_author: '1'
date_created: 2018-12-11T11:48:43Z
date_published: 2013-12-26T00:00:00Z
date_updated: 2025-09-29T14:32:42Z
day: '26'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00537
ec_funded: 1
external_id:
  isi:
  - '000331533500002'
file:
- access_level: open_access
  checksum: 0185b3c4d7df9a94bd3ce5a66d213506
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-31T10:36:43Z
  date_updated: 2020-07-14T12:48:11Z
  file_id: '5902'
  file_name: 2013_FrontiersPlant_Cuesta.pdf
  file_size: 710835
  relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
fulldoi: https://doi.org/10.3389/fpls.2013.00537
has_accepted_license: '1'
intvolume: '         4'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6820'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Systems approaches to study root architecture dynamics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 4
year: '2013'
...
---
_id: '9459'
abstract:
- lang: eng
  text: Nucleosome remodelers of the DDM1/Lsh family are required for DNA methylation
    of transposable elements, but the reason for this is unknown. How DDM1 interacts
    with other methylation pathways, such as small-RNA-directed DNA methylation (RdDM),
    which is thought to mediate plant asymmetric methylation through DRM enzymes,
    is also unclear. Here, we show that most asymmetric methylation is facilitated
    by DDM1 and mediated by the methyltransferase CMT2 separately from RdDM. We find
    that heterochromatic sequences preferentially require DDM1 for DNA methylation
    and that this preference depends on linker histone H1. RdDM is instead inhibited
    by heterochromatin and absolutely requires the nucleosome remodeler DRD1. Together,
    DDM1 and RdDM mediate nearly all transposon methylation and collaborate to repress
    transposition and regulate the methylation and expression of genes. Our results
    indicate that DDM1 provides DNA methyltransferases access to H1-containing heterochromatin
    to allow stable silencing of transposable elements in cooperation with the RdDM
    pathway.
article_processing_charge: No
article_type: original
author:
- first_name: Assaf
  full_name: Zemach, Assaf
  last_name: Zemach
- first_name: M. Yvonne
  full_name: Kim, M. Yvonne
  last_name: Kim
- first_name: Ping-Hung
  full_name: Hsieh, Ping-Hung
  last_name: Hsieh
- first_name: Devin
  full_name: Coleman-Derr, Devin
  last_name: Coleman-Derr
- first_name: Leor
  full_name: Eshed-Williams, Leor
  last_name: Eshed-Williams
- first_name: Ka
  full_name: Thao, Ka
  last_name: Thao
- first_name: Stacey L.
  full_name: Harmer, Stacey L.
  last_name: Harmer
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Zemach A, Kim MY, Hsieh P-H, et al. The Arabidopsis nucleosome remodeler DDM1
    allows DNA methyltransferases to access H1-containing heterochromatin. <i>Cell</i>.
    2013;153(1):193-205. doi:<a href="https://doi.org/10.1016/j.cell.2013.02.033">10.1016/j.cell.2013.02.033</a>
  apa: Zemach, A., Kim, M. Y., Hsieh, P.-H., Coleman-Derr, D., Eshed-Williams, L.,
    Thao, K., … Zilberman, D. (2013). The Arabidopsis nucleosome remodeler DDM1 allows
    DNA methyltransferases to access H1-containing heterochromatin. <i>Cell</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.cell.2013.02.033">https://doi.org/10.1016/j.cell.2013.02.033</a>
  chicago: Zemach, Assaf, M. Yvonne Kim, Ping-Hung Hsieh, Devin Coleman-Derr, Leor
    Eshed-Williams, Ka Thao, Stacey L. Harmer, and Daniel Zilberman. “The Arabidopsis
    Nucleosome Remodeler DDM1 Allows DNA Methyltransferases to Access H1-Containing
    Heterochromatin.” <i>Cell</i>. Elsevier, 2013. <a href="https://doi.org/10.1016/j.cell.2013.02.033">https://doi.org/10.1016/j.cell.2013.02.033</a>.
  ieee: A. Zemach <i>et al.</i>, “The Arabidopsis nucleosome remodeler DDM1 allows
    DNA methyltransferases to access H1-containing heterochromatin,” <i>Cell</i>,
    vol. 153, no. 1. Elsevier, pp. 193–205, 2013.
  ista: Zemach A, Kim MY, Hsieh P-H, Coleman-Derr D, Eshed-Williams L, Thao K, Harmer
    SL, Zilberman D. 2013. The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases
    to access H1-containing heterochromatin. Cell. 153(1), 193–205.
  mla: Zemach, Assaf, et al. “The Arabidopsis Nucleosome Remodeler DDM1 Allows DNA
    Methyltransferases to Access H1-Containing Heterochromatin.” <i>Cell</i>, vol.
    153, no. 1, Elsevier, 2013, pp. 193–205, doi:<a href="https://doi.org/10.1016/j.cell.2013.02.033">10.1016/j.cell.2013.02.033</a>.
  short: A. Zemach, M.Y. Kim, P.-H. Hsieh, D. Coleman-Derr, L. Eshed-Williams, K.
    Thao, S.L. Harmer, D. Zilberman, Cell 153 (2013) 193–205.
date_created: 2021-06-04T12:23:28Z
date_published: 2013-03-28T00:00:00Z
date_updated: 2021-12-14T08:25:35Z
day: '28'
department:
- _id: DaZi
doi: 10.1016/j.cell.2013.02.033
extern: '1'
external_id:
  pmid:
  - '23540698'
fulldoi: https://doi.org/10.1016/j.cell.2013.02.033
intvolume: '       153'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cell.2013.02.033
month: '03'
oa: 1
oa_version: Published Version
page: 193-205
pmid: 1
publication: Cell
publication_identifier:
  eissn:
  - 1097-4172
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to
  access H1-containing heterochromatin
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 153
year: '2013'
...
---
_id: '9481'
abstract:
- lang: eng
  text: Arabidopsis thaliana endosperm, a transient tissue that nourishes the embryo,
    exhibits extensive localized DNA demethylation on maternally inherited chromosomes.
    Demethylation mediates parent-of-origin–specific (imprinted) gene expression but
    is apparently unnecessary for the extensive accumulation of maternally biased
    small RNA (sRNA) molecules detected in seeds. Endosperm DNA in the distantly related
    monocots rice and maize is likewise locally hypomethylated, but whether this hypomethylation
    is generally parent-of-origin specific is unknown. Imprinted expression of sRNA
    also remains uninvestigated in monocot seeds. Here, we report high-coverage sequencing
    of the Kitaake rice cultivar that enabled us to show that localized hypomethylation
    in rice endosperm occurs solely on the maternal genome, preferring regions of
    high DNA accessibility. Maternally expressed imprinted genes are enriched for
    hypomethylation at putative promoter regions and transcriptional termini and paternally
    expressed genes at promoters and gene bodies, mirroring our recent results in
    A. thaliana. However, unlike in A. thaliana, rice endosperm sRNA populations are
    dominated by specific strong sRNA-producing loci, and imprinted 24-nt sRNAs are
    expressed from both parental genomes and correlate with hypomethylation. Overlaps
    between imprinted sRNA loci and imprinted genes expressed from opposite alleles
    suggest that sRNAs may regulate genomic imprinting. Whereas sRNAs in seedling
    tissues primarily originate from small class II (cut-and-paste) transposable elements,
    those in endosperm are more uniformly derived, including sequences from other
    transposon classes, as well as genic and intergenic regions. Our data indicate
    that the endosperm exhibits a unique pattern of sRNA expression and suggest that
    localized hypomethylation of maternal endosperm DNA is conserved in flowering
    plants.
article_processing_charge: No
article_type: original
author:
- first_name: Jessica A.
  full_name: Rodrigues, Jessica A.
  last_name: Rodrigues
- first_name: Randy
  full_name: Ruan, Randy
  last_name: Ruan
- first_name: Toshiro
  full_name: Nishimura, Toshiro
  last_name: Nishimura
- first_name: Manoj K.
  full_name: Sharma, Manoj K.
  last_name: Sharma
- first_name: Rita
  full_name: Sharma, Rita
  last_name: Sharma
- first_name: Pamela C
  full_name: Ronald, Pamela C
  last_name: Ronald
- first_name: Robert L.
  full_name: Fischer, Robert L.
  last_name: Fischer
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Rodrigues JA, Ruan R, Nishimura T, et al. Imprinted expression of genes and
    small RNA is associated with localized hypomethylation of the maternal genome
    in rice endosperm. <i>Proceedings of the National Academy of Sciences</i>. 2013;110(19):7934-7939.
    doi:<a href="https://doi.org/10.1073/pnas.1306164110">10.1073/pnas.1306164110</a>
  apa: Rodrigues, J. A., Ruan, R., Nishimura, T., Sharma, M. K., Sharma, R., Ronald,
    P. C., … Zilberman, D. (2013). Imprinted expression of genes and small RNA is
    associated with localized hypomethylation of the maternal genome in rice endosperm.
    <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.1306164110">https://doi.org/10.1073/pnas.1306164110</a>
  chicago: Rodrigues, Jessica A., Randy Ruan, Toshiro Nishimura, Manoj K. Sharma,
    Rita Sharma, Pamela C Ronald, Robert L. Fischer, and Daniel Zilberman. “Imprinted
    Expression of Genes and Small RNA Is Associated with Localized Hypomethylation
    of the Maternal Genome in Rice Endosperm.” <i>Proceedings of the National Academy
    of Sciences</i>. National Academy of Sciences, 2013. <a href="https://doi.org/10.1073/pnas.1306164110">https://doi.org/10.1073/pnas.1306164110</a>.
  ieee: J. A. Rodrigues <i>et al.</i>, “Imprinted expression of genes and small RNA
    is associated with localized hypomethylation of the maternal genome in rice endosperm,”
    <i>Proceedings of the National Academy of Sciences</i>, vol. 110, no. 19. National
    Academy of Sciences, pp. 7934–7939, 2013.
  ista: Rodrigues JA, Ruan R, Nishimura T, Sharma MK, Sharma R, Ronald PC, Fischer
    RL, Zilberman D. 2013. Imprinted expression of genes and small RNA is associated
    with localized hypomethylation of the maternal genome in rice endosperm. Proceedings
    of the National Academy of Sciences. 110(19), 7934–7939.
  mla: Rodrigues, Jessica A., et al. “Imprinted Expression of Genes and Small RNA
    Is Associated with Localized Hypomethylation of the Maternal Genome in Rice Endosperm.”
    <i>Proceedings of the National Academy of Sciences</i>, vol. 110, no. 19, National
    Academy of Sciences, 2013, pp. 7934–39, doi:<a href="https://doi.org/10.1073/pnas.1306164110">10.1073/pnas.1306164110</a>.
  short: J.A. Rodrigues, R. Ruan, T. Nishimura, M.K. Sharma, R. Sharma, P.C. Ronald,
    R.L. Fischer, D. Zilberman, Proceedings of the National Academy of Sciences 110
    (2013) 7934–7939.
date_created: 2021-06-07T07:31:02Z
date_published: 2013-05-07T00:00:00Z
date_updated: 2021-12-14T08:26:44Z
day: '07'
department:
- _id: DaZi
doi: 10.1073/pnas.1306164110
extern: '1'
external_id:
  pmid:
  - '23613580'
fulldoi: https://doi.org/10.1073/pnas.1306164110
intvolume: '       110'
issue: '19'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1073/pnas.1306164110
month: '05'
oa: 1
oa_version: Published Version
page: 7934-7939
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Imprinted expression of genes and small RNA is associated with localized hypomethylation
  of the maternal genome in rice endosperm
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 110
year: '2013'
...
---
_id: '9520'
abstract:
- lang: eng
  text: Plants undergo alternation of generation in which reproductive cells develop
    in the plant body ("sporophytic generation") and then differentiate into a multicellular
    gamete-forming "gametophytic generation." Different populations of helper cells
    assist in this transgenerational journey, with somatic tissues supporting early
    development and single nurse cells supporting gametogenesis. New data reveal a
    two-way relationship between early reproductive cells and their helpers involving
    complex epigenetic and signaling networks determining cell number and fate. Later,
    the egg cell plays a central role in specifying accessory cells, whereas in both
    gametophytes, companion cells contribute non-cell-autonomously to the epigenetic
    landscape of the gamete genomes.
article_processing_charge: No
article_type: review
author:
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
- first_name: Hugh
  full_name: Dickinson, Hugh
  last_name: Dickinson
citation:
  ama: 'Feng X, Zilberman D, Dickinson H. A conversation across generations: Soma-germ
    cell crosstalk in plants. <i>Developmental Cell</i>. 2013;24(3):215-225. doi:<a
    href="https://doi.org/10.1016/j.devcel.2013.01.014">10.1016/j.devcel.2013.01.014</a>'
  apa: 'Feng, X., Zilberman, D., &#38; Dickinson, H. (2013). A conversation across
    generations: Soma-germ cell crosstalk in plants. <i>Developmental Cell</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.devcel.2013.01.014">https://doi.org/10.1016/j.devcel.2013.01.014</a>'
  chicago: 'Feng, Xiaoqi, Daniel Zilberman, and Hugh Dickinson. “A Conversation across
    Generations: Soma-Germ Cell Crosstalk in Plants.” <i>Developmental Cell</i>. Elsevier,
    2013. <a href="https://doi.org/10.1016/j.devcel.2013.01.014">https://doi.org/10.1016/j.devcel.2013.01.014</a>.'
  ieee: 'X. Feng, D. Zilberman, and H. Dickinson, “A conversation across generations:
    Soma-germ cell crosstalk in plants,” <i>Developmental Cell</i>, vol. 24, no. 3.
    Elsevier, pp. 215–225, 2013.'
  ista: 'Feng X, Zilberman D, Dickinson H. 2013. A conversation across generations:
    Soma-germ cell crosstalk in plants. Developmental Cell. 24(3), 215–225.'
  mla: 'Feng, Xiaoqi, et al. “A Conversation across Generations: Soma-Germ Cell Crosstalk
    in Plants.” <i>Developmental Cell</i>, vol. 24, no. 3, Elsevier, 2013, pp. 215–25,
    doi:<a href="https://doi.org/10.1016/j.devcel.2013.01.014">10.1016/j.devcel.2013.01.014</a>.'
  short: X. Feng, D. Zilberman, H. Dickinson, Developmental Cell 24 (2013) 215–225.
date_created: 2021-06-08T06:14:50Z
date_published: 2013-02-11T00:00:00Z
date_updated: 2023-05-08T11:00:59Z
day: '11'
department:
- _id: DaZi
- _id: XiFe
doi: 10.1016/j.devcel.2013.01.014
extern: '1'
external_id:
  pmid:
  - '23410937'
fulldoi: https://doi.org/10.1016/j.devcel.2013.01.014
intvolume: '        24'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.devcel.2013.01.014
month: '02'
oa: 1
oa_version: Published Version
page: 215-225
pmid: 1
publication: Developmental Cell
publication_identifier:
  eissn:
  - 1878-1551
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A conversation across generations: Soma-germ cell crosstalk in plants'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2013'
...
---
_id: '9749'
abstract:
- lang: eng
  text: Cooperative behavior, where one individual incurs a cost to help another,
    is a wide spread phenomenon. Here we study direct reciprocity in the context of
    the alternating Prisoner's Dilemma. We consider all strategies that can be implemented
    by one and two-state automata. We calculate the payoff matrix of all pairwise
    encounters in the presence of noise. We explore deterministic selection dynamics
    with and without mutation. Using different error rates and payoff values, we observe
    convergence to a small number of distinct equilibria. Two of them are uncooperative
    strict Nash equilibria representing always-defect (ALLD) and Grim. The third equilibrium
    is mixed and represents a cooperative alliance of several strategies, dominated
    by a strategy which we call Forgiver. Forgiver cooperates whenever the opponent
    has cooperated; it defects once when the opponent has defected, but subsequently
    Forgiver attempts to re-establish cooperation even if the opponent has defected
    again. Forgiver is not an evolutionarily stable strategy, but the alliance, which
    it rules, is asymptotically stable. For a wide range of parameter values the most
    commonly observed outcome is convergence to the mixed equilibrium, dominated by
    Forgiver. Our results show that although forgiving might incur a short-term loss
    it can lead to a long-term gain. Forgiveness facilitates stable cooperation in
    the presence of exploitation and noise.
article_processing_charge: No
author:
- first_name: Benjamin
  full_name: Zagorsky, Benjamin
  last_name: Zagorsky
- first_name: Johannes
  full_name: Reiter, Johannes
  id: 4A918E98-F248-11E8-B48F-1D18A9856A87
  last_name: Reiter
  orcid: 0000-0002-0170-7353
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
citation:
  ama: Zagorsky B, Reiter J, Chatterjee K, Nowak M. Forgiver triumphs in alternating
    prisoner’s dilemma . 2013. doi:<a href="https://doi.org/10.1371/journal.pone.0080814.s001">10.1371/journal.pone.0080814.s001</a>
  apa: Zagorsky, B., Reiter, J., Chatterjee, K., &#38; Nowak, M. (2013). Forgiver
    triumphs in alternating prisoner’s dilemma . Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0080814.s001">https://doi.org/10.1371/journal.pone.0080814.s001</a>
  chicago: Zagorsky, Benjamin, Johannes Reiter, Krishnendu Chatterjee, and Martin
    Nowak. “Forgiver Triumphs in Alternating Prisoner’s Dilemma .” Public Library
    of Science, 2013. <a href="https://doi.org/10.1371/journal.pone.0080814.s001">https://doi.org/10.1371/journal.pone.0080814.s001</a>.
  ieee: B. Zagorsky, J. Reiter, K. Chatterjee, and M. Nowak, “Forgiver triumphs in
    alternating prisoner’s dilemma .” Public Library of Science, 2013.
  ista: Zagorsky B, Reiter J, Chatterjee K, Nowak M. 2013. Forgiver triumphs in alternating
    prisoner’s dilemma , Public Library of Science, <a href="https://doi.org/10.1371/journal.pone.0080814.s001">10.1371/journal.pone.0080814.s001</a>.
  mla: Zagorsky, Benjamin, et al. <i>Forgiver Triumphs in Alternating Prisoner’s Dilemma
    </i>. Public Library of Science, 2013, doi:<a href="https://doi.org/10.1371/journal.pone.0080814.s001">10.1371/journal.pone.0080814.s001</a>.
  short: B. Zagorsky, J. Reiter, K. Chatterjee, M. Nowak, (2013).
date_created: 2021-07-28T15:45:07Z
date_published: 2013-12-12T00:00:00Z
date_updated: 2025-09-29T14:30:03Z
day: '12'
department:
- _id: KrCh
doi: 10.1371/journal.pone.0080814.s001
fulldoi: https://doi.org/10.1371/journal.pone.0080814.s001
month: '12'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '2247'
    relation: used_in_publication
    status: public
status: public
title: 'Forgiver triumphs in alternating prisoner''s dilemma '
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2013'
...
---
_id: '9751'
abstract:
- lang: eng
  text: High relatedness among interacting individuals has generally been considered
    a precondition for the evolution of altruism. However, kin-selection theory also
    predicts the evolution of altruism when relatedness is low, as long as the cost
    of the altruistic act is minor compared to its benefit. Here, we demonstrate evidence
    for a low-cost altruistic act in bacteria. We investigated Escherichia coli responding
    to the attack of an obligately lytic phage by committing suicide in order to prevent
    parasite transmission to nearby relatives. We found that bacterial suicide provides
    large benefits to survivors at marginal costs to committers. The cost of suicide
    was low because infected cells are moribund, rapidly dying upon phage infection,
    such that no more opportunity for reproduction remains. As a consequence of its
    marginal cost, host suicide was selectively favoured even when relatedness between
    committers and survivors approached zero. Altogether, our findings demonstrate
    that low-cost suicide can evolve with ease, represents an effective host-defence
    strategy, and seems to be widespread among microbes. Moreover, low-cost suicide
    might also occur in higher organisms as exemplified by infected social insect
    workers leaving the colony to die in isolation.
article_processing_charge: No
author:
- first_name: Dominik
  full_name: Refardt, Dominik
  last_name: Refardt
- first_name: Tobias
  full_name: Bergmiller, Tobias
  id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Bergmiller
  orcid: 0000-0001-5396-4346
- first_name: Rolf
  full_name: Kümmerli, Rolf
  last_name: Kümmerli
citation:
  ama: 'Refardt D, Bergmiller T, Kümmerli R. Data from: Altruism can evolve when relatedness
    is low: evidence from bacteria committing suicide upon phage infection. 2013.
    doi:<a href="https://doi.org/10.5061/dryad.b1q2n">10.5061/dryad.b1q2n</a>'
  apa: 'Refardt, D., Bergmiller, T., &#38; Kümmerli, R. (2013). Data from: Altruism
    can evolve when relatedness is low: evidence from bacteria committing suicide
    upon phage infection. Dryad. <a href="https://doi.org/10.5061/dryad.b1q2n">https://doi.org/10.5061/dryad.b1q2n</a>'
  chicago: 'Refardt, Dominik, Tobias Bergmiller, and Rolf Kümmerli. “Data from: Altruism
    Can Evolve When Relatedness Is Low: Evidence from Bacteria Committing Suicide
    upon Phage Infection.” Dryad, 2013. <a href="https://doi.org/10.5061/dryad.b1q2n">https://doi.org/10.5061/dryad.b1q2n</a>.'
  ieee: 'D. Refardt, T. Bergmiller, and R. Kümmerli, “Data from: Altruism can evolve
    when relatedness is low: evidence from bacteria committing suicide upon phage
    infection.” Dryad, 2013.'
  ista: 'Refardt D, Bergmiller T, Kümmerli R. 2013. Data from: Altruism can evolve
    when relatedness is low: evidence from bacteria committing suicide upon phage
    infection, Dryad, <a href="https://doi.org/10.5061/dryad.b1q2n">10.5061/dryad.b1q2n</a>.'
  mla: 'Refardt, Dominik, et al. <i>Data from: Altruism Can Evolve When Relatedness
    Is Low: Evidence from Bacteria Committing Suicide upon Phage Infection</i>. Dryad,
    2013, doi:<a href="https://doi.org/10.5061/dryad.b1q2n">10.5061/dryad.b1q2n</a>.'
  short: D. Refardt, T. Bergmiller, R. Kümmerli, (2013).
date_created: 2021-07-30T08:08:09Z
date_published: 2013-03-21T00:00:00Z
date_updated: 2025-09-29T13:41:12Z
day: '21'
department:
- _id: CaGu
doi: 10.5061/dryad.b1q2n
fulldoi: https://doi.org/10.5061/dryad.b1q2n
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.b1q2n
month: '03'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '2853'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Altruism can evolve when relatedness is low: evidence from bacteria
  committing suicide upon phage infection'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2013'
...
---
_id: '9754'
abstract:
- lang: eng
  text: Short-read sequencing technologies have in principle made it feasible to draw
    detailed inferences about the recent history of any organism. In practice, however,
    this remains challenging due to the difficulty of genome assembly in most organisms
    and the lack of statistical methods powerful enough to discriminate among recent,
    non-equilibrium histories. We address both the assembly and inference challenges.
    We develop a bioinformatic pipeline for generating outgroup-rooted alignments
    of orthologous sequence blocks from de novo low-coverage short-read data for a
    small number of genomes, and show how such sequence blocks can be used to fit
    explicit models of population divergence and admixture in a likelihood framework.
    To illustrate our approach, we reconstruct the Pleistocene history of an oak-feeding
    insect (the oak gallwasp Biorhiza pallida) which, in common with many other taxa,
    was restricted during Pleistocene ice ages to a longitudinal series of southern
    refugia spanning theWestern Palaearctic. Our analysis of sequence blocks sampled
    from a single genome from each of three major glacial refugia reveals support
    for an unexpected history dominated by recent admixture. Despite the fact that
    80% of the genome is affected by admixture during the last glacial cycle, we are
    able to infer the deeper divergence history of these populations. These inferences
    are robust to variation in block length, mutation model, and the sampling location
    of individual genomes within refugia. This combination of de novo assembly and
    numerical likelihood calculation provides a powerful framework for estimating
    recent population history that can be applied to any organism without the need
    for prior genetic resources.
article_processing_charge: No
author:
- first_name: Jack
  full_name: Hearn, Jack
  last_name: Hearn
- first_name: Graham
  full_name: Stone, Graham
  last_name: Stone
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Konrad
  full_name: Lohse, Konrad
  last_name: Lohse
- first_name: Lynsey
  full_name: Bunnefeld, Lynsey
  last_name: Bunnefeld
citation:
  ama: 'Hearn J, Stone G, Barton NH, Lohse K, Bunnefeld L. Data from: Likelihood-based
    inference of population history from low coverage de novo genome assemblies. 2013.
    doi:<a href="https://doi.org/10.5061/dryad.r3r60">10.5061/dryad.r3r60</a>'
  apa: 'Hearn, J., Stone, G., Barton, N. H., Lohse, K., &#38; Bunnefeld, L. (2013).
    Data from: Likelihood-based inference of population history from low coverage
    de novo genome assemblies. Dryad. <a href="https://doi.org/10.5061/dryad.r3r60">https://doi.org/10.5061/dryad.r3r60</a>'
  chicago: 'Hearn, Jack, Graham Stone, Nicholas H Barton, Konrad Lohse, and Lynsey
    Bunnefeld. “Data from: Likelihood-Based Inference of Population History from Low
    Coverage de Novo Genome Assemblies.” Dryad, 2013. <a href="https://doi.org/10.5061/dryad.r3r60">https://doi.org/10.5061/dryad.r3r60</a>.'
  ieee: 'J. Hearn, G. Stone, N. H. Barton, K. Lohse, and L. Bunnefeld, “Data from:
    Likelihood-based inference of population history from low coverage de novo genome
    assemblies.” Dryad, 2013.'
  ista: 'Hearn J, Stone G, Barton NH, Lohse K, Bunnefeld L. 2013. Data from: Likelihood-based
    inference of population history from low coverage de novo genome assemblies, Dryad,
    <a href="https://doi.org/10.5061/dryad.r3r60">10.5061/dryad.r3r60</a>.'
  mla: 'Hearn, Jack, et al. <i>Data from: Likelihood-Based Inference of Population
    History from Low Coverage de Novo Genome Assemblies</i>. Dryad, 2013, doi:<a href="https://doi.org/10.5061/dryad.r3r60">10.5061/dryad.r3r60</a>.'
  short: J. Hearn, G. Stone, N.H. Barton, K. Lohse, L. Bunnefeld, (2013).
date_created: 2021-07-30T08:31:22Z
date_published: 2013-10-01T00:00:00Z
date_updated: 2025-09-29T11:38:51Z
day: '01'
department:
- _id: NiBa
doi: 10.5061/dryad.r3r60
fulldoi: https://doi.org/10.5061/dryad.r3r60
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.r3r60
month: '10'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '2170'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Likelihood-based inference of population history from low coverage
  de novo genome assemblies'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2013'
...
---
_id: '6440'
abstract:
- lang: eng
  text: In order to guarantee that each method of a data structure updates the logical
    state exactly once, al-most all non-blocking implementations employ Compare-And-Swap
    (CAS) based synchronization. For FIFO  queue  implementations  this  translates  into  concurrent  enqueue  or  dequeue  methods
    competing among themselves to update the same variable, the tail or the head,
    respectively, leading to high contention and poor scalability. Recent non-blocking
    queue implementations try to alleviate high contentionby increasing the number
    of contention points, all the while using CAS-based synchronization. Furthermore,
    obtaining a wait-free implementation with competition is achieved by additional
    synchronization which leads to further degradation of performance.In this paper
    we formalize the notion of competitiveness of a synchronizing statement which
    can beused as a measure for the scalability of concurrent implementations.  We
    present a new queue implementation, the Speculative Pairing (SP) queue, which,
    as we show, decreases competitiveness by using Fetch-And-Increment (FAI) instead
    of CAS. We prove that the SP queue is linearizable and lock-free.We also show
    that replacing CAS with FAI leads to wait-freedom for dequeue methods without
    an adverse effect on performance.  In fact, our experiments suggest that the SP
    queue can perform and scale better than the state-of-the-art queue implementations.
alternative_title:
- IST Austria Technical Report
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Hannes
  full_name: Payer, Hannes
  last_name: Payer
- first_name: Ali
  full_name: Sezgin, Ali
  id: 4C7638DA-F248-11E8-B48F-1D18A9856A87
  last_name: Sezgin
citation:
  ama: Henzinger TA, Payer H, Sezgin A. <i>Replacing Competition with Cooperation
    to Achieve Scalable Lock-Free FIFO Queues </i>. IST Austria; 2013. doi:<a href="https://doi.org/10.15479/AT:IST-2013-124-v1-1">10.15479/AT:IST-2013-124-v1-1</a>
  apa: Henzinger, T. A., Payer, H., &#38; Sezgin, A. (2013). <i>Replacing competition
    with cooperation to achieve scalable lock-free FIFO queues </i>. IST Austria.
    <a href="https://doi.org/10.15479/AT:IST-2013-124-v1-1">https://doi.org/10.15479/AT:IST-2013-124-v1-1</a>
  chicago: Henzinger, Thomas A, Hannes Payer, and Ali Sezgin. <i>Replacing Competition
    with Cooperation to Achieve Scalable Lock-Free FIFO Queues </i>. IST Austria,
    2013. <a href="https://doi.org/10.15479/AT:IST-2013-124-v1-1">https://doi.org/10.15479/AT:IST-2013-124-v1-1</a>.
  ieee: T. A. Henzinger, H. Payer, and A. Sezgin, <i>Replacing competition with cooperation
    to achieve scalable lock-free FIFO queues </i>. IST Austria, 2013.
  ista: Henzinger TA, Payer H, Sezgin A. 2013. Replacing competition with cooperation
    to achieve scalable lock-free FIFO queues , IST Austria, 23p.
  mla: Henzinger, Thomas A., et al. <i>Replacing Competition with Cooperation to Achieve
    Scalable Lock-Free FIFO Queues </i>. IST Austria, 2013, doi:<a href="https://doi.org/10.15479/AT:IST-2013-124-v1-1">10.15479/AT:IST-2013-124-v1-1</a>.
  short: T.A. Henzinger, H. Payer, A. Sezgin, Replacing Competition with Cooperation
    to Achieve Scalable Lock-Free FIFO Queues , IST Austria, 2013.
date_created: 2019-05-13T14:13:27Z
date_published: 2013-06-13T00:00:00Z
date_updated: 2020-07-14T23:06:19Z
day: '13'
ddc:
- '000'
- '005'
department:
- _id: ToHe
doi: 10.15479/AT:IST-2013-124-v1-1
file:
- access_level: open_access
  checksum: a219ba4eada6cd62befed52262ee15d4
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-13T14:11:39Z
  date_updated: 2020-07-14T12:47:30Z
  file_id: '6441'
  file_name: 2013_TechRep_Henzinger.pdf
  file_size: 549684
  relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
fulldoi: https://doi.org/10.15479/AT:IST-2013-124-v1-1
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '23'
publication_identifier:
  issn:
  - 2664-1690
publication_status: published
publisher: IST Austria
pubrep_id: '124'
status: public
title: 'Replacing competition with cooperation to achieve scalable lock-free FIFO
  queues '
type: technical_report
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '3116'
abstract:
- lang: eng
  text: Multithreaded programs coordinate their interaction through synchronization
    primitives like mutexes and semaphores, which are managed by an OS-provided resource
    manager. We propose algorithms for the automatic construction of code-aware resource
    managers for multithreaded embedded applications. Such managers use knowledge
    about the structure and resource usage (mutex and semaphore usage) of the threads
    to guarantee deadlock freedom and progress while managing resources in an efficient
    way. Our algorithms compute managers as winning strategies in certain infinite
    games, and produce a compact code description of these strategies. We have implemented
    the algorithms in the tool Cynthesis. Given a multithreaded program in C, the
    tool produces C code implementing a code-aware resource manager. We show in experiments
    that Cynthesis produces compact resource managers within a few minutes on a set
    of embedded benchmarks with up to 6 threads. © 2012 Springer Science+Business
    Media, LLC.
acknowledgement: This research was supported in part by the National Science Foundation
  CAREER award CCR-0132780, by the ONR grant N00014-02-1-0671, by the National Science
  Foundation grants CCR-0427202 and CCR-0234690, and by the ARP award TO.030.MM.D.
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Luca
  full_name: De Alfaro, Luca
  last_name: De Alfaro
- first_name: Marco
  full_name: Faella, Marco
  last_name: Faella
- first_name: Ritankar
  full_name: Majumdar, Ritankar
  last_name: Majumdar
- first_name: Vishwanath
  full_name: Raman, Vishwanath
  last_name: Raman
citation:
  ama: Chatterjee K, De Alfaro L, Faella M, Majumdar R, Raman V. Code aware resource
    management. <i>Formal Methods in System Design</i>. 2013;42(2):142-174. doi:<a
    href="https://doi.org/10.1007/s10703-012-0170-4">10.1007/s10703-012-0170-4</a>
  apa: Chatterjee, K., De Alfaro, L., Faella, M., Majumdar, R., &#38; Raman, V. (2013).
    Code aware resource management. <i>Formal Methods in System Design</i>. Springer.
    <a href="https://doi.org/10.1007/s10703-012-0170-4">https://doi.org/10.1007/s10703-012-0170-4</a>
  chicago: Chatterjee, Krishnendu, Luca De Alfaro, Marco Faella, Ritankar Majumdar,
    and Vishwanath Raman. “Code Aware Resource Management.” <i>Formal Methods in System
    Design</i>. Springer, 2013. <a href="https://doi.org/10.1007/s10703-012-0170-4">https://doi.org/10.1007/s10703-012-0170-4</a>.
  ieee: K. Chatterjee, L. De Alfaro, M. Faella, R. Majumdar, and V. Raman, “Code aware
    resource management,” <i>Formal Methods in System Design</i>, vol. 42, no. 2.
    Springer, pp. 142–174, 2013.
  ista: Chatterjee K, De Alfaro L, Faella M, Majumdar R, Raman V. 2013. Code aware
    resource management. Formal Methods in System Design. 42(2), 142–174.
  mla: Chatterjee, Krishnendu, et al. “Code Aware Resource Management.” <i>Formal
    Methods in System Design</i>, vol. 42, no. 2, Springer, 2013, pp. 142–74, doi:<a
    href="https://doi.org/10.1007/s10703-012-0170-4">10.1007/s10703-012-0170-4</a>.
  short: K. Chatterjee, L. De Alfaro, M. Faella, R. Majumdar, V. Raman, Formal Methods
    in System Design 42 (2013) 142–174.
date_created: 2018-12-11T12:01:29Z
date_published: 2013-04-01T00:00:00Z
date_updated: 2025-09-29T13:24:54Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/s10703-012-0170-4
external_id:
  isi:
  - '000316677500002'
fulldoi: https://doi.org/10.1007/s10703-012-0170-4
intvolume: '        42'
isi: 1
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 142 - 174
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '3583'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Code aware resource management
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 42
year: '2013'
...
---
_id: '3261'
abstract:
- lang: eng
  text: Cells in a developing embryo have no direct way of &quot;measuring&quot; their
    physical position. Through a variety of processes, however, the expression levels
    of multiple genes come to be correlated with position, and these expression levels
    thus form a code for &quot;positional information.&quot; We show how to measure
    this information, in bits, using the gap genes in the Drosophila embryo as an
    example. Individual genes carry nearly two bits of information, twice as much
    as expected if the expression patterns consisted only of on/off domains separated
    by sharp boundaries. Taken together, four gap genes carry enough information to
    define a cell's location with an error bar of ~1% along the anterior-posterior
    axis of the embryo. This precision is nearly enough for each cell to have a unique
    identity, which is the maximum information the system can use, and is nearly constant
    along the length of the embryo. We argue that this constancy is a signature of
    optimality in the transmission of information from primary morphogen inputs to
    the output of the gap gene network.
article_processing_charge: No
author:
- first_name: Julien
  full_name: Dubuis, Julien
  last_name: Dubuis
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Eric
  full_name: Wieschaus, Eric
  last_name: Wieschaus
- first_name: Thomas
  full_name: Gregor, Thomas
  last_name: Gregor
- first_name: William
  full_name: Bialek, William
  last_name: Bialek
citation:
  ama: Dubuis J, Tkačik G, Wieschaus E, Gregor T, Bialek W. Positional information,
    in bits. <i>PNAS</i>. 2013;110(41):16301-16308. doi:<a href="https://doi.org/10.1073/pnas.1315642110">10.1073/pnas.1315642110</a>
  apa: Dubuis, J., Tkačik, G., Wieschaus, E., Gregor, T., &#38; Bialek, W. (2013).
    Positional information, in bits. <i>PNAS</i>. National Academy of Sciences. <a
    href="https://doi.org/10.1073/pnas.1315642110">https://doi.org/10.1073/pnas.1315642110</a>
  chicago: Dubuis, Julien, Gašper Tkačik, Eric Wieschaus, Thomas Gregor, and William
    Bialek. “Positional Information, in Bits.” <i>PNAS</i>. National Academy of Sciences,
    2013. <a href="https://doi.org/10.1073/pnas.1315642110">https://doi.org/10.1073/pnas.1315642110</a>.
  ieee: J. Dubuis, G. Tkačik, E. Wieschaus, T. Gregor, and W. Bialek, “Positional
    information, in bits,” <i>PNAS</i>, vol. 110, no. 41. National Academy of Sciences,
    pp. 16301–16308, 2013.
  ista: Dubuis J, Tkačik G, Wieschaus E, Gregor T, Bialek W. 2013. Positional information,
    in bits. PNAS. 110(41), 16301–16308.
  mla: Dubuis, Julien, et al. “Positional Information, in Bits.” <i>PNAS</i>, vol.
    110, no. 41, National Academy of Sciences, 2013, pp. 16301–08, doi:<a href="https://doi.org/10.1073/pnas.1315642110">10.1073/pnas.1315642110</a>.
  short: J. Dubuis, G. Tkačik, E. Wieschaus, T. Gregor, W. Bialek, PNAS 110 (2013)
    16301–16308.
date_created: 2018-12-11T12:02:19Z
date_published: 2013-10-08T00:00:00Z
date_updated: 2025-09-29T13:24:21Z
day: '08'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1073/pnas.1315642110
external_id:
  isi:
  - '000325395600021'
  pmid:
  - '24089448'
file:
- access_level: open_access
  checksum: ecd859fe52a562193027d428b5524a8d
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-22T13:53:23Z
  date_updated: 2020-07-14T12:46:06Z
  file_id: '5873'
  file_name: 2013_PNAS_Dubuis.pdf
  file_size: 1670548
  relation: main_file
file_date_updated: 2020-07-14T12:46:06Z
fulldoi: https://doi.org/10.1073/pnas.1315642110
has_accepted_license: '1'
intvolume: '       110'
isi: 1
issue: '41'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 16301 - 16308
pmid: 1
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3387'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Positional information, in bits
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 110
year: '2013'
...
---
_id: '3321'
author:
- first_name: Novi
  full_name: Quadrianto, Novi
  last_name: Quadrianto
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: 'Quadrianto N, Lampert C. Kernel based learning. In: Dubitzky W, Wolkenhauer
    O, Cho K, Yokota H, eds. <i>Encyclopedia of Systems Biology</i>. Vol 3. Springer;
    2013:1069-1069. doi:<a href="https://doi.org/10.1007/978-1-4419-9863-7_604">10.1007/978-1-4419-9863-7_604</a>'
  apa: Quadrianto, N., &#38; Lampert, C. (2013). Kernel based learning. In W. Dubitzky,
    O. Wolkenhauer, K. Cho, &#38; H. Yokota (Eds.), <i>Encyclopedia of Systems Biology</i>
    (Vol. 3, pp. 1069–1069). Springer. <a href="https://doi.org/10.1007/978-1-4419-9863-7_604">https://doi.org/10.1007/978-1-4419-9863-7_604</a>
  chicago: Quadrianto, Novi, and Christoph Lampert. “Kernel Based Learning.” In <i>Encyclopedia
    of Systems Biology</i>, edited by Werner Dubitzky, Olaf Wolkenhauer, Kwang Cho,
    and Hiroki Yokota, 3:1069–1069. Springer, 2013. <a href="https://doi.org/10.1007/978-1-4419-9863-7_604">https://doi.org/10.1007/978-1-4419-9863-7_604</a>.
  ieee: N. Quadrianto and C. Lampert, “Kernel based learning,” in <i>Encyclopedia
    of Systems Biology</i>, vol. 3, W. Dubitzky, O. Wolkenhauer, K. Cho, and H. Yokota,
    Eds. Springer, 2013, pp. 1069–1069.
  ista: 'Quadrianto N, Lampert C. 2013.Kernel based learning. In: Encyclopedia of
    Systems Biology. vol. 3, 1069–1069.'
  mla: Quadrianto, Novi, and Christoph Lampert. “Kernel Based Learning.” <i>Encyclopedia
    of Systems Biology</i>, edited by Werner Dubitzky et al., vol. 3, Springer, 2013,
    pp. 1069–1069, doi:<a href="https://doi.org/10.1007/978-1-4419-9863-7_604">10.1007/978-1-4419-9863-7_604</a>.
  short: N. Quadrianto, C. Lampert, in:, W. Dubitzky, O. Wolkenhauer, K. Cho, H. Yokota
    (Eds.), Encyclopedia of Systems Biology, Springer, 2013, pp. 1069–1069.
date_created: 2018-12-11T12:02:39Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:38Z
day: '01'
department:
- _id: ChLa
doi: 10.1007/978-1-4419-9863-7_604
editor:
- first_name: Werner
  full_name: Dubitzky, Werner
  last_name: Dubitzky
- first_name: Olaf
  full_name: Wolkenhauer, Olaf
  last_name: Wolkenhauer
- first_name: Kwang
  full_name: Cho, Kwang
  last_name: Cho
- first_name: Hiroki
  full_name: Yokota, Hiroki
  last_name: Yokota
fulldoi: https://doi.org/10.1007/978-1-4419-9863-7_604
intvolume: '         3'
language:
- iso: eng
month: '01'
oa_version: None
page: 1069 - 1069
publication: Encyclopedia of Systems Biology
publication_status: published
publisher: Springer
publist_id: '3314'
quality_controlled: '1'
status: public
title: Kernel based learning
type: encyclopedia_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2013'
...
