---
OA_place: publisher
OA_type: diamond
_id: '20037'
abstract:
- lang: eng
text: 'Disentangling polysemantic neurons is at the core of many current approaches
to interpretability of large language models. Here we attempt to study how disentanglement
can be used to understand performance, particularly under weight sparsity, a leading
post-training optimization technique. We suggest a novel measure for estimating
neuronal entanglement: the Wasserstein distance of a neuron''s output distribution
to a Gaussian. Moreover, we show the existence of a small number of highly entangled
"Wasserstein Neurons" in each linear layer of an LLM, characterized by their highly
non-Gaussian output distributions, their role in mapping similar inputs to dissimilar
outputs, and their significant impact on model accuracy. To study these phenomena,
we propose a new experimental framework for disentangling polysemantic neurons.
Our framework separates each layer''s inputs to create a mixture of experts where
each neuron''s output is computed by a mixture of neurons of lower Wasserstein
distance, each better at maintaining accuracy when sparsified without retraining.
We provide strong evidence that this is because the mixture of sparse experts
is effectively disentangling the input-output relationship of individual neurons,
in particular the difficult Wasserstein neurons.'
acknowledgement: "The authors would like to extend their gratitude to Lori Leu for
her insightful comments on the\r\napplication of the Wasserstein distance metric.
We also wish to thank Elias Frantar for his help in\r\nworking with the SparseGPT
implementation and his advice for the project. Additionally, we would like to thank
Tony Tong Wang and Thomas Athey for their valuable feedback and constructive discussions.\r\nThis
work was supported by an NIH Brains CONNECTS U01 grant and AMD’s AI & HPC Fund."
article_processing_charge: No
arxiv: 1
author:
- first_name: Shashata
full_name: Sawmya, Shashata
last_name: Sawmya
- first_name: Linghao
full_name: Kong, Linghao
last_name: Kong
- first_name: Ilia
full_name: Markov, Ilia
id: D0CF4148-C985-11E9-8066-0BDEE5697425
last_name: Markov
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Nir
full_name: Shavit, Nir
last_name: Shavit
citation:
ama: 'Sawmya S, Kong L, Markov I, Alistarh D-A, Shavit N. Wasserstein distances,
neuronal entanglement, and sparsity. In: 13th International Conference on Learning
Representations. ICLR; 2025:26244-26274.'
apa: 'Sawmya, S., Kong, L., Markov, I., Alistarh, D.-A., & Shavit, N. (2025).
Wasserstein distances, neuronal entanglement, and sparsity. In 13th International
Conference on Learning Representations (pp. 26244–26274). Singapore, Singapore:
ICLR.'
chicago: Sawmya, Shashata, Linghao Kong, Ilia Markov, Dan-Adrian Alistarh, and Nir
Shavit. “Wasserstein Distances, Neuronal Entanglement, and Sparsity.” In 13th
International Conference on Learning Representations, 26244–74. ICLR, 2025.
ieee: S. Sawmya, L. Kong, I. Markov, D.-A. Alistarh, and N. Shavit, “Wasserstein
distances, neuronal entanglement, and sparsity,” in 13th International Conference
on Learning Representations, Singapore, Singapore, 2025, pp. 26244–26274.
ista: 'Sawmya S, Kong L, Markov I, Alistarh D-A, Shavit N. 2025. Wasserstein distances,
neuronal entanglement, and sparsity. 13th International Conference on Learning
Representations. ICLR: International Conference on Learning Representations, 26244–26274.'
mla: Sawmya, Shashata, et al. “Wasserstein Distances, Neuronal Entanglement, and
Sparsity.” 13th International Conference on Learning Representations, ICLR,
2025, pp. 26244–74.
short: S. Sawmya, L. Kong, I. Markov, D.-A. Alistarh, N. Shavit, in:, 13th International
Conference on Learning Representations, ICLR, 2025, pp. 26244–26274.
conference:
end_date: 2025-04-28
location: Singapore, Singapore
name: 'ICLR: International Conference on Learning Representations'
start_date: 2025-04-24
corr_author: '1'
date_created: 2025-07-20T22:02:03Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2025-08-04T08:16:43Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
external_id:
arxiv:
- '2405.15756'
file:
- access_level: open_access
checksum: 39a8fa7dbdd7029859e156f53f20f6bc
content_type: application/pdf
creator: dernst
date_created: 2025-08-04T08:14:09Z
date_updated: 2025-08-04T08:14:09Z
file_id: '20110'
file_name: 2025_ICLR_Sawmya.pdf
file_size: 5447177
relation: main_file
success: 1
file_date_updated: 2025-08-04T08:14:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 26244-26274
publication: 13th International Conference on Learning Representations
publication_identifier:
isbn:
- '9798331320850'
publication_status: published
publisher: ICLR
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/Shavit-Lab/Sparse-Expansion
scopus_import: '1'
status: public
title: Wasserstein distances, neuronal entanglement, and sparsity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: diamond
_id: '20038'
abstract:
- lang: eng
text: Pruning eliminates unnecessary parameters in neural networks; it offers a
promising solution to the growing computational demands of large language models
(LLMs). While many focus on post-training pruning, sparse pre-training--which
combines pruning and pre-training into a single phase--provides a simpler alternative.
In this work, we present the first systematic exploration of optimal sparse pre-training
configurations for LLMs through an examination of 80 unique pruning schedules
across different sparsity levels and training durations. We find that initiating
pruning at 25% of total training compute and concluding at 75% achieves near-optimal
final evaluation loss. These findings provide valuable insights for efficient
and effective sparse pre-training of LLMs. Furthermore, we propose a new scaling
law that modifies the Chinchilla scaling law to use the average parameter count
over pre-training. Through empirical and theoretical validation, we demonstrate
that this modified scaling law accurately models evaluation loss for both sparsely
and densely pre-trained LLMs, unifying scaling laws across pre-training paradigms.
Our findings indicate that while sparse pre-training achieves the same final model
quality as dense pre-training for equivalent compute budgets, it provides substantial
benefits through reduced model size, enabling significant potential computational
savings during inference.
acknowledgement: "We are deeply grateful to Elias Frantar, Naveen Kumar, Sanjiv Kumar,
Daniel\r\nM. Roy, and Clemens Schaefer for their valuable feedback and thoughtful
review of this paper.\r\nWe also acknowledge the critical support provided by the
Google CoreML Performance Team, and Google Research during this project. We further
recognize the extended team at Google DeepMind, who enabled and supported this research
direction.\r\nThis work was in part supported by the Sloan Foundation, the MIT-IBM
Watson AI Lab, Apple, and SRC JUMP 2.0 (CoCoSys)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Tian
full_name: Jin, Tian
last_name: Jin
- first_name: Ahmed Imtiaz
full_name: Humayun, Ahmed Imtiaz
last_name: Humayun
- first_name: Utku
full_name: Evci, Utku
last_name: Evci
- first_name: Suvinay
full_name: Subramanian, Suvinay
last_name: Subramanian
- first_name: Amir
full_name: Yazdanbakhsh, Amir
last_name: Yazdanbakhsh
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Gintare Karolina
full_name: Dziugaite, Gintare Karolina
last_name: Dziugaite
citation:
ama: 'Jin T, Humayun AI, Evci U, et al. The journey matters: Average parameter count
over pre-training unifies sparse and dense scaling laws. In: 13th International
Conference on Learning Representations. ICLR; 2025:85165-85181.'
apa: 'Jin, T., Humayun, A. I., Evci, U., Subramanian, S., Yazdanbakhsh, A., Alistarh,
D.-A., & Dziugaite, G. K. (2025). The journey matters: Average parameter count
over pre-training unifies sparse and dense scaling laws. In 13th International
Conference on Learning Representations (pp. 85165–85181). Singapore, Singapore:
ICLR.'
chicago: 'Jin, Tian, Ahmed Imtiaz Humayun, Utku Evci, Suvinay Subramanian, Amir
Yazdanbakhsh, Dan-Adrian Alistarh, and Gintare Karolina Dziugaite. “The Journey
Matters: Average Parameter Count over Pre-Training Unifies Sparse and Dense Scaling
Laws.” In 13th International Conference on Learning Representations, 85165–81.
ICLR, 2025.'
ieee: 'T. Jin et al., “The journey matters: Average parameter count over
pre-training unifies sparse and dense scaling laws,” in 13th International
Conference on Learning Representations, Singapore, Singapore, 2025, pp. 85165–85181.'
ista: 'Jin T, Humayun AI, Evci U, Subramanian S, Yazdanbakhsh A, Alistarh D-A, Dziugaite
GK. 2025. The journey matters: Average parameter count over pre-training unifies
sparse and dense scaling laws. 13th International Conference on Learning Representations.
ICLR: International Conference on Learning Representations, 85165–85181.'
mla: 'Jin, Tian, et al. “The Journey Matters: Average Parameter Count over Pre-Training
Unifies Sparse and Dense Scaling Laws.” 13th International Conference on Learning
Representations, ICLR, 2025, pp. 85165–81.'
short: T. Jin, A.I. Humayun, U. Evci, S. Subramanian, A. Yazdanbakhsh, D.-A. Alistarh,
G.K. Dziugaite, in:, 13th International Conference on Learning Representations,
ICLR, 2025, pp. 85165–85181.
conference:
end_date: 2025-04-28
location: Singapore, Singapore
name: 'ICLR: International Conference on Learning Representations'
start_date: 2025-04-24
date_created: 2025-07-20T22:02:03Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2025-08-04T08:24:59Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
external_id:
arxiv:
- '2501.12486 '
file:
- access_level: open_access
checksum: dbc27120e9aba67dffbd9e5d513a6803
content_type: application/pdf
creator: dernst
date_created: 2025-08-04T08:23:47Z
date_updated: 2025-08-04T08:23:47Z
file_id: '20111'
file_name: 2025_ICLR_Jin.pdf
file_size: 704989
relation: main_file
success: 1
file_date_updated: 2025-08-04T08:23:47Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 85165-85181
publication: 13th International Conference on Learning Representations
publication_identifier:
isbn:
- '9798331320850'
publication_status: published
publisher: ICLR
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The journey matters: Average parameter count over pre-training unifies sparse
and dense scaling laws'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20040'
abstract:
- lang: eng
text: 'Contractive coupling rates have been recently introduced by Conforti as a
tool to establish convex Sobolev inequalities (including modified log-Sobolev
and Poincaré inequality) for some classes of Markov chains. In this work, for
most of the examples discussed by Conforti, we use contractive coupling rates
to prove stronger inequalities, in the form of curvature lower bounds (in entropic
and discrete Bakry–Émery sense) and geodesic convexity of some entropic functionals.
In addition, we recall and give straightforward generalizations of some notions
of coarse Ricci curvature, and we discuss some of their properties and relations
with the concepts of couplings and coupling rates: as an application, we show
exponential contraction of the p-Wasserstein distance for the heat flow in the
aforementioned examples.'
acknowledgement: "The author warmly thanks Jan Maas for suggesting the project and
for his guidance, and Melchior Wirth and Haonan Zhang for useful discussions. The
author is also grateful to an anonymous reviewer for carefully reading the manuscript
and providing many valuable suggestions. The author gratefully acknowledges support
by the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation programme\r\n(grant agreement No. 716117) and by the Austrian Science
Fund (FWF), Project SFB F65."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Francesco
full_name: Pedrotti, Francesco
id: d3ac8ac6-dc8d-11ea-abe3-e2a9628c4c3c
last_name: Pedrotti
citation:
ama: Pedrotti F. Contractive coupling rates and curvature lower bounds for Markov
chains. The Annals of Applied Probability. 2025;35(1):196-250. doi:10.1214/24-aap2113
apa: Pedrotti, F. (2025). Contractive coupling rates and curvature lower bounds
for Markov chains. The Annals of Applied Probability. Institute of Mathematical
Statistics. https://doi.org/10.1214/24-aap2113
chicago: Pedrotti, Francesco. “Contractive Coupling Rates and Curvature Lower Bounds
for Markov Chains.” The Annals of Applied Probability. Institute of Mathematical
Statistics, 2025. https://doi.org/10.1214/24-aap2113.
ieee: F. Pedrotti, “Contractive coupling rates and curvature lower bounds for Markov
chains,” The Annals of Applied Probability, vol. 35, no. 1. Institute of
Mathematical Statistics, pp. 196–250, 2025.
ista: Pedrotti F. 2025. Contractive coupling rates and curvature lower bounds for
Markov chains. The Annals of Applied Probability. 35(1), 196–250.
mla: Pedrotti, Francesco. “Contractive Coupling Rates and Curvature Lower Bounds
for Markov Chains.” The Annals of Applied Probability, vol. 35, no. 1,
Institute of Mathematical Statistics, 2025, pp. 196–250, doi:10.1214/24-aap2113.
short: F. Pedrotti, The Annals of Applied Probability 35 (2025) 196–250.
corr_author: '1'
date_created: 2025-07-21T07:49:15Z
date_published: 2025-02-01T00:00:00Z
date_updated: 2025-11-05T13:50:07Z
day: '01'
department:
- _id: JaMa
doi: 10.1214/24-aap2113
ec_funded: 1
external_id:
arxiv:
- '2308.00516'
isi:
- '001434322900006'
intvolume: ' 35'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2308.00516
month: '02'
oa: 1
oa_version: Preprint
page: 196 - 250
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
publication: The Annals of Applied Probability
publication_identifier:
issn:
- 1050-5164
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
related_material:
record:
- id: '17351'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Contractive coupling rates and curvature lower bounds for Markov chains
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2025'
...
---
OA_place: publisher
OA_type: free access
_id: '20042'
abstract:
- lang: eng
text: 'The Cover Feature shows how recessed microelectrodes were employed as a versatile
binder-free platform to investigate the electrochemical performance of Prussian
Blue analogues (PBA), a class of promising battery materials, concerning capacity
in varying aqueous electrolytes. To corroborate the micro-electrochemical findings,
both ex-situ and operando chemical characterizations were conducted, offering
complementary insights into the structural and chemical evolution of the PBA material
during electrochemical cycling. More information can be found in the Research
Article by W. Schuhmann and co-workers (DOI: 10.1002/batt.202400743).'
article_number: e202580302
article_processing_charge: No
author:
- first_name: Nomnotho
full_name: Jiyane, Nomnotho
last_name: Jiyane
- first_name: Carla
full_name: Santana Santos, Carla
last_name: Santana Santos
- first_name: Igor
full_name: Echevarria Poza, Igor
id: fbae1d3b-8142-11ed-8927-a8cf34feb495
last_name: Echevarria Poza
- first_name: Mario
full_name: Palacios Corella, Mario
id: 452e82c6-803f-11ed-ab7e-ca0439e73a5d
last_name: Palacios Corella
- first_name: Muhammad Adib
full_name: Abdillah Mahbub, Muhammad Adib
last_name: Abdillah Mahbub
- first_name: Gimena
full_name: Marin‐Tajadura, Gimena
last_name: Marin‐Tajadura
- first_name: Thomas
full_name: Quast, Thomas
last_name: Quast
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Edgar
full_name: Ventosa, Edgar
last_name: Ventosa
- first_name: Wolfgang
full_name: Schuhmann, Wolfgang
last_name: Schuhmann
citation:
ama: 'Jiyane N, Santana Santos C, Echevarria Poza I, et al. Cover Feature: Recessed
Microelectrodes as a Platform to Investigate the Intrinsic Redox Process of Prussian
Blue Analogs for Energy Storage Application. Vol 8. Wiley; 2025. doi:10.1002/batt.202580302'
apa: 'Jiyane, N., Santana Santos, C., Echevarria Poza, I., Palacios Corella, M.,
Abdillah Mahbub, M. A., Marin‐Tajadura, G., … Schuhmann, W. (2025). Cover Feature:
Recessed microelectrodes as a platform to investigate the intrinsic redox process
of Prussian blue analogs for energy storage application. Batteries &
Supercaps (Vol. 8). Wiley. https://doi.org/10.1002/batt.202580302'
chicago: 'Jiyane, Nomnotho, Carla Santana Santos, Igor Echevarria Poza, Mario Palacios
Corella, Muhammad Adib Abdillah Mahbub, Gimena Marin‐Tajadura, Thomas Quast, Maria
Ibáñez, Edgar Ventosa, and Wolfgang Schuhmann. Cover Feature: Recessed Microelectrodes
as a Platform to Investigate the Intrinsic Redox Process of Prussian Blue Analogs
for Energy Storage Application. Batteries & Supercaps. Vol. 8.
Wiley, 2025. https://doi.org/10.1002/batt.202580302.'
ieee: 'N. Jiyane et al., Cover Feature: Recessed microelectrodes as a
platform to investigate the intrinsic redox process of Prussian blue analogs for
energy storage application, vol. 8, no. 3. Wiley, 2025.'
ista: 'Jiyane N, Santana Santos C, Echevarria Poza I, Palacios Corella M, Abdillah
Mahbub MA, Marin‐Tajadura G, Quast T, Ibáñez M, Ventosa E, Schuhmann W. 2025.
Cover Feature: Recessed microelectrodes as a platform to investigate the intrinsic
redox process of Prussian blue analogs for energy storage application, Wiley,p.'
mla: 'Jiyane, Nomnotho, et al. “Cover Feature: Recessed Microelectrodes as a Platform
to Investigate the Intrinsic Redox Process of Prussian Blue Analogs for Energy
Storage Application.” Batteries & Supercaps, vol. 8, no. 3, e202580302,
Wiley, 2025, doi:10.1002/batt.202580302.'
short: 'N. Jiyane, C. Santana Santos, I. Echevarria Poza, M. Palacios Corella, M.A.
Abdillah Mahbub, G. Marin‐Tajadura, T. Quast, M. Ibáñez, E. Ventosa, W. Schuhmann,
Cover Feature: Recessed Microelectrodes as a Platform to Investigate the Intrinsic
Redox Process of Prussian Blue Analogs for Energy Storage Application, Wiley,
2025.'
date_created: 2025-07-21T07:52:59Z
date_published: 2025-03-01T00:00:00Z
date_updated: 2026-06-18T18:18:57Z
day: '01'
ddc:
- '530'
department:
- _id: MaIb
doi: 10.1002/batt.202580302
intvolume: ' 8'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/batt.202580302
month: '03'
oa: 1
oa_version: Published Version
publication: Batteries & Supercaps
publication_identifier:
eissn:
- 2566-6223
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'Cover Feature: Recessed microelectrodes as a platform to investigate the intrinsic
redox process of Prussian blue analogs for energy storage application'
type: other_academic_publication
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20043'
abstract:
- lang: eng
text: We establish an isomorphism of complex K-theory of the moduli space M of
“SL n ”-Higgs bundles of degree d and rank n (in the sense of Hausel–Thaddeus)
and twisted complex K-theory of the orbifold M of PGL n -Higgs bundles of degree
e, where (n,d)=(n,e)=1. Along the way, we prove the vanishing of torsion for H
∗ ( M ) and certain twisted complex K-theory groups of M . We also extend Arinkin’s
autoduality of compactified Jacobian to a derived equivalence between SL n -
and PGL n -Hitchin systems over the elliptic locus. In the appendix, we develop
a formalism of G-sheaves of spectra, generalising equivariant homotopy theory
to a relative setting.
acknowledgement: "It is a pleasure to thank Tom Baird for sharing his insights about
vanishing of torsion for H.M{1\r\n2/. Furthermore, we would like to thank him for
bringing [25] to our attention. We also thank Alexander Kupers for enlightening
conversations about the Atiyah–Hirzebruch spectral sequence and for pointing out
a reference. We are grateful to Victoria Hoskins and Simon Pepin-Lehalleur for sharing
a preprint of their recent paper on a motivic version of topological mirror symmetry
and for useful remarks on Section 6. Anne Larsen pointed out that our previous proof
Lemma 4.5 was incomplete, we thank her for bringing this to our attention. We are
grateful to the anonymous referee for many valuable comments that have improved
the paper tremendously. The report we received was one of the most detailed referee
report either of us has ever seen. We thank them for their hard work and the resulting
contribution to this paper. Michael Groechenig was supported by an NSERC discovery
grant and an Alfred P. Sloan\r\nfellowship. Shiyu Shen has received funding from
the European Union’s Horizon 2020 research\r\nand innovation program under the Marie
Skłodowska-Curie grant agreement No. 101034413."
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Groechenig, Michael
last_name: Groechenig
- first_name: Shiyu
full_name: Shen, Shiyu
id: 544cccd3-9005-11ec-87bc-94aef1c5b814
last_name: Shen
orcid: 0000-0002-4444-8718
citation:
ama: Groechenig M, Shen S. Complex K-theory of moduli spaces of Higgs bundles. Journal
of the European Mathematical Society. 2025. doi:10.4171/jems/1601
apa: Groechenig, M., & Shen, S. (2025). Complex K-theory of moduli spaces of
Higgs bundles. Journal of the European Mathematical Society. EMS Press.
https://doi.org/10.4171/jems/1601
chicago: Groechenig, Michael, and Shiyu Shen. “Complex K-Theory of Moduli Spaces
of Higgs Bundles.” Journal of the European Mathematical Society. EMS Press,
2025. https://doi.org/10.4171/jems/1601.
ieee: M. Groechenig and S. Shen, “Complex K-theory of moduli spaces of Higgs bundles,”
Journal of the European Mathematical Society. EMS Press, 2025.
ista: Groechenig M, Shen S. 2025. Complex K-theory of moduli spaces of Higgs bundles.
Journal of the European Mathematical Society.
mla: Groechenig, Michael, and Shiyu Shen. “Complex K-Theory of Moduli Spaces of
Higgs Bundles.” Journal of the European Mathematical Society, EMS Press,
2025, doi:10.4171/jems/1601.
short: M. Groechenig, S. Shen, Journal of the European Mathematical Society (2025).
corr_author: '1'
date_created: 2025-07-21T07:54:50Z
date_published: 2025-03-20T00:00:00Z
date_updated: 2026-06-16T14:34:30Z
day: '20'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.4171/jems/1601
ec_funded: 1
external_id:
arxiv:
- '2212.10695'
isi:
- '001608254800001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.4171/JEMS/1601
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Journal of the European Mathematical Society
publication_identifier:
eissn:
- 1435-9863
issn:
- 1435-9855
publication_status: epub_ahead
publisher: EMS Press
quality_controlled: '1'
status: public
title: Complex K-theory of moduli spaces of Higgs bundles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20044'
abstract:
- lang: eng
text: Genetic trade-offs—which occur when variants that are beneficial in some contexts
of natural selection are harmful in others—can influence a wide range of evolutionary
phenomena, from the maintenance of genetic variation to the evolution of aging
and sex differences. An extensive body of evolutionary theory has focused on the
consequences of such trade-offs, and recent analyses of Fisher’s geometric model
have further quantified the expected proportion of new mutations that exhibit
trade-offs. However, the theory remains silent regarding the prevalence of trade-offs
among the variants that contribute to adaptation. Here, we extend Fisher’s geometric
model to predict the prevalence of trade-offs among the adaptive mutations that
become established or fixed in a population. We consider trade-offs between sexes,
habitats, fitness components, and temporally fluctuating environments. In all
4 scenarios, trade-off alleles are consistently under-represented among established
relative to new beneficial mutations—an effect that arises from the greater susceptibility
of trade-off alleles to genetic drift. Adaptation during a population size decline
exacerbates this deficit of trade-offs among established mutations, whereas population
expansions dampen it. Consequently, threatened populations should primarily adapt
using unconditionally beneficial alleles, while invasive populations are more
prone to adaptation using variants that exhibit trade-offs.
acknowledgement: 'Support for this research came from the European Society of Evolutionary
Biology (ESEB) through a “Special Topics Network” grant. Further financial support
came from the European Research Council (ERC-2023-STG916 #101117517, to C.O.), the
Swedish Research Council (#2022-03603, to C.O.; #2020‑03123, to E.I.S.), the Research
Council of Norway (Norges forskningsråd #302619, to D.G.), the Alexander von Humboldt
Foundation and the GenEvo graduate school (to H.K.), the Foundation for Zoological
Research and the Birgitta Sintring Foundation (#S2024-0007, to M.K.Z.), a postdoctoral
fellowship from the Consejo Nacional de Humanidades, Ciencias y Tecnología (to A.N.B.),
and a H2020 Marie Skłodowska-Curie COFUND Action fellowship (#101034413, to F.R.).
We wish to express our deepest gratitude to Lotte de Vries for extensive discussion
of the project, rederiving some of our results, and providing comments on an earlier
version of the manuscript, and to the European Society of Evolutionary Biology (ESEB)
for a “Special Topics Network” grant that supported workshops that initiated this
collaboration and facilitated many new ideas and friendships. We also thank two
anonymous reviewers for their thoughtful comments and suggestions that helped us
to substantially improve upon the original version of the article.'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Tim
full_name: Connallon, Tim
last_name: Connallon
- first_name: Peter
full_name: Czuppon, Peter
last_name: Czuppon
- first_name: Colin
full_name: Olito, Colin
last_name: Olito
- first_name: Debora
full_name: Goedert, Debora
last_name: Goedert
- first_name: Hanna
full_name: Kokko, Hanna
last_name: Kokko
- first_name: Angela
full_name: Nava-Bolaños, Angela
last_name: Nava-Bolaños
- first_name: Sofie
full_name: Nilén, Sofie
last_name: Nilén
- first_name: Erik I
full_name: Svensson, Erik I
last_name: Svensson
- first_name: Martyna
full_name: Zwoinska, Martyna
last_name: Zwoinska
- first_name: Ludovic
full_name: Dutoit, Ludovic
last_name: Dutoit
- first_name: Filip
full_name: Ruzicka, Filip
id: 347955dd-57b0-11ee-9095-c28bdd368f4b
last_name: Ruzicka
citation:
ama: Connallon T, Czuppon P, Olito C, et al. Predicting the prevalence of genetic
trade-offs among adaptive substitutions. Evolution. 2025;79(7):1243-1255.
doi:10.1093/evolut/qpaf061
apa: Connallon, T., Czuppon, P., Olito, C., Goedert, D., Kokko, H., Nava-Bolaños,
A., … Ruzicka, F. (2025). Predicting the prevalence of genetic trade-offs among
adaptive substitutions. Evolution. Oxford University Press. https://doi.org/10.1093/evolut/qpaf061
chicago: Connallon, Tim, Peter Czuppon, Colin Olito, Debora Goedert, Hanna Kokko,
Angela Nava-Bolaños, Sofie Nilén, et al. “Predicting the Prevalence of Genetic
Trade-Offs among Adaptive Substitutions.” Evolution. Oxford University
Press, 2025. https://doi.org/10.1093/evolut/qpaf061.
ieee: T. Connallon et al., “Predicting the prevalence of genetic trade-offs
among adaptive substitutions,” Evolution, vol. 79, no. 7. Oxford University
Press, pp. 1243–1255, 2025.
ista: Connallon T, Czuppon P, Olito C, Goedert D, Kokko H, Nava-Bolaños A, Nilén
S, Svensson EI, Zwoinska M, Dutoit L, Ruzicka F. 2025. Predicting the prevalence
of genetic trade-offs among adaptive substitutions. Evolution. 79(7), 1243–1255.
mla: Connallon, Tim, et al. “Predicting the Prevalence of Genetic Trade-Offs among
Adaptive Substitutions.” Evolution, vol. 79, no. 7, Oxford University Press,
2025, pp. 1243–55, doi:10.1093/evolut/qpaf061.
short: T. Connallon, P. Czuppon, C. Olito, D. Goedert, H. Kokko, A. Nava-Bolaños,
S. Nilén, E.I. Svensson, M. Zwoinska, L. Dutoit, F. Ruzicka, Evolution 79 (2025)
1243–1255.
date_created: 2025-07-21T07:57:28Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2025-09-30T14:06:38Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/evolut/qpaf061
ec_funded: 1
external_id:
isi:
- '001477180800001'
file:
- access_level: open_access
checksum: 68c4c996d0e8c9ee3d4fb61bca75b31a
content_type: application/pdf
creator: dernst
date_created: 2025-07-22T10:04:57Z
date_updated: 2025-07-22T10:04:57Z
file_id: '20068'
file_name: 2025_Evolution_Connallon.pdf
file_size: 8150623
relation: main_file
success: 1
file_date_updated: 2025-07-22T10:04:57Z
has_accepted_license: '1'
intvolume: ' 79'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 1243-1255
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
issn:
- 0014-3820
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: Predicting the prevalence of genetic trade-offs among adaptive substitutions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 79
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: repository
OA_type: green
_id: '20045'
abstract:
- lang: eng
text: We consider the time evolution of the renormalized Nelson model, which describes
N bosons linearly coupled to a quantized scalar field, in the mean-field limit
of many particles N≫1 with coupling constant proportional to N^−1/2. First, we
show that initial states exhibiting Bose–Einstein condensation for the particles
and approximating a coherent state for the quantum field retain their structure
under the many-body time evolution. Concretely, the dynamics of the reduced densities
are approximated by solutions of two coupled PDEs, the Schrödinger–Klein–Gordon
equations. Second, we construct a renormalized Bogoliubov evolution that describes
the quantum fluctuations around the Schrödinger–Klein–Gordon equations. This evolution
is used to extend the approximation of the evolved many-body state to the full
norm topology. In summary, we provide a comprehensive analysis of the Nelson model
that reveals the role of renormalization in the mean-field Bogoliubov theory.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marco
full_name: Falconi, Marco
last_name: Falconi
- first_name: Jonas
full_name: Lampart, Jonas
last_name: Lampart
- first_name: Nikolai
full_name: Leopold, Nikolai
last_name: Leopold
- first_name: David Johannes
full_name: Mitrouskas, David Johannes
id: cbddacee-2b11-11eb-a02e-a2e14d04e52d
last_name: Mitrouskas
citation:
ama: Falconi M, Lampart J, Leopold N, Mitrouskas DJ. Renormalized Bogoliubov theory
for the Nelson model. Annales de l’Institut Henri Poincaré C. 2025. doi:10.4171/aihpc/154
apa: Falconi, M., Lampart, J., Leopold, N., & Mitrouskas, D. J. (2025). Renormalized
Bogoliubov theory for the Nelson model. Annales de l’Institut Henri Poincaré
C. EMS Press. https://doi.org/10.4171/aihpc/154
chicago: Falconi, Marco, Jonas Lampart, Nikolai Leopold, and David Johannes Mitrouskas.
“Renormalized Bogoliubov Theory for the Nelson Model.” Annales de l’Institut
Henri Poincaré C. EMS Press, 2025. https://doi.org/10.4171/aihpc/154.
ieee: M. Falconi, J. Lampart, N. Leopold, and D. J. Mitrouskas, “Renormalized Bogoliubov
theory for the Nelson model,” Annales de l’Institut Henri Poincaré C. EMS
Press, 2025.
ista: Falconi M, Lampart J, Leopold N, Mitrouskas DJ. 2025. Renormalized Bogoliubov
theory for the Nelson model. Annales de l’Institut Henri Poincaré C.
mla: Falconi, Marco, et al. “Renormalized Bogoliubov Theory for the Nelson Model.”
Annales de l’Institut Henri Poincaré C, EMS Press, 2025, doi:10.4171/aihpc/154.
short: M. Falconi, J. Lampart, N. Leopold, D.J. Mitrouskas, Annales de l’Institut
Henri Poincaré C (2025).
date_created: 2025-07-21T07:59:16Z
date_published: 2025-05-06T00:00:00Z
date_updated: 2025-12-30T07:31:09Z
day: '06'
department:
- _id: RoSe
doi: 10.4171/aihpc/154
external_id:
arxiv:
- '2305.06722'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2305.06722
month: '05'
oa: 1
oa_version: Preprint
publication: Annales de l'Institut Henri Poincaré C
publication_identifier:
eissn:
- 1873-1430
issn:
- 0294-1449
publication_status: epub_ahead
publisher: EMS Press
quality_controlled: '1'
status: public
title: Renormalized Bogoliubov theory for the Nelson model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20046'
abstract:
- lang: eng
text: A Laplacian matrix is a real symmetric matrix whose row and column sums are
zero. We investigate the limiting distribution of the largest eigenvalues of a
Laplacian random matrix with Gaussian entries. Unlike many classical matrix ensembles,
this random matrix model contains dependent entries. Our main results show that
the extreme eigenvalues of this model exhibit Poisson statistics. In particular,
after properly shifting and scaling, we show that the largest eigenvalue converges
to the Gumbel distribution as the dimension of the matrix tends to infinity. While
the largest diagonal entry is also shown to have Gumbel fluctuations, there is
a rather surprising difference between its deterministic centering term and the
centering term required for the largest eigenvalues.
acknowledgement: "The authors thank Santiago Arenas-Velilla and Victor Pérez-Abreu
for comments on an earlier draft of this manuscript and for contributing Appendix
A. The authors also thank Yan Fyodorov for providing useful references.\r\nA. Campbell
was partially supported by the European Research Council Grant No. 101020331. K.
Luh was supported in part by the Ralph E. Powe Junior Faculty Enhancement Award
and Simons Foundation Grant MP-TSM-00001988. S. O’Rourke has been supported in part
by NSF CAREER grant DMS-2143142. "
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Andrew J
full_name: Campbell, Andrew J
id: 582b06a9-1f1c-11ee-b076-82ffce00dde4
last_name: Campbell
- first_name: Kyle
full_name: Luh, Kyle
last_name: Luh
- first_name: Sean
full_name: O’Rourke, Sean
last_name: O’Rourke
- first_name: Santiago
full_name: Arenas-Velilla, Santiago
last_name: Arenas-Velilla
- first_name: Victor
full_name: Perez-Abreu, Victor
last_name: Perez-Abreu
citation:
ama: Campbell AJ, Luh K, O’Rourke S, Arenas-Velilla S, Perez-Abreu V. Extreme eigenvalues
of Laplacian random matrices with Gaussian entries. Electronic Journal of Probability.
2025;30:1-52. doi:10.1214/25-ejp1366
apa: Campbell, A. J., Luh, K., O’Rourke, S., Arenas-Velilla, S., & Perez-Abreu,
V. (2025). Extreme eigenvalues of Laplacian random matrices with Gaussian entries.
Electronic Journal of Probability. Institute of Mathematical Statistics.
https://doi.org/10.1214/25-ejp1366
chicago: Campbell, Andrew J, Kyle Luh, Sean O’Rourke, Santiago Arenas-Velilla, and
Victor Perez-Abreu. “Extreme Eigenvalues of Laplacian Random Matrices with Gaussian
Entries.” Electronic Journal of Probability. Institute of Mathematical
Statistics, 2025. https://doi.org/10.1214/25-ejp1366.
ieee: A. J. Campbell, K. Luh, S. O’Rourke, S. Arenas-Velilla, and V. Perez-Abreu,
“Extreme eigenvalues of Laplacian random matrices with Gaussian entries,” Electronic
Journal of Probability, vol. 30. Institute of Mathematical Statistics, pp.
1–52, 2025.
ista: Campbell AJ, Luh K, O’Rourke S, Arenas-Velilla S, Perez-Abreu V. 2025. Extreme
eigenvalues of Laplacian random matrices with Gaussian entries. Electronic Journal
of Probability. 30, 1–52.
mla: Campbell, Andrew J., et al. “Extreme Eigenvalues of Laplacian Random Matrices
with Gaussian Entries.” Electronic Journal of Probability, vol. 30, Institute
of Mathematical Statistics, 2025, pp. 1–52, doi:10.1214/25-ejp1366.
short: A.J. Campbell, K. Luh, S. O’Rourke, S. Arenas-Velilla, V. Perez-Abreu, Electronic
Journal of Probability 30 (2025) 1–52.
corr_author: '1'
date_created: 2025-07-21T08:06:18Z
date_published: 2025-06-27T00:00:00Z
date_updated: 2025-09-30T14:07:19Z
day: '27'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1214/25-ejp1366
ec_funded: 1
external_id:
arxiv:
- '2211.17175'
isi:
- '001540927000024'
file:
- access_level: open_access
checksum: a7a9f2bb7a6295786c16d4c7bd612621
content_type: application/pdf
creator: dernst
date_created: 2025-07-23T08:35:53Z
date_updated: 2025-07-23T08:35:53Z
file_id: '20069'
file_name: 2025_ElectronJourProbab_Campbell.pdf
file_size: 580591
relation: main_file
success: 1
file_date_updated: 2025-07-23T08:35:53Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1-52
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Electronic Journal of Probability
publication_identifier:
eissn:
- 1083-6489
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
status: public
title: Extreme eigenvalues of Laplacian random matrices with Gaussian entries
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 30
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20048'
abstract:
- lang: eng
text: 'During embryonic development, cell behaviors need to be tightly regulated
in time and space. Yet how the temporal and spatial regulations of cell behaviors
are interconnected during embryonic development remains elusive. To address this,
we turned to zebrafish gastrulation, the process whereby dynamic cell behaviors
generate the three principal germ layers of the early embryo. Here, we show that
Hoxb cluster genes are expressed in a temporally collinear manner at the blastoderm
margin, where mesodermal and endodermal (mesendoderm) progenitor cells are specified
and ingress to form mesendoderm/hypoblast. Functional analysis shows that these
Hoxb genes regulate the timing of cell ingression: under- or overexpression of
Hoxb genes perturb the timing of mesendoderm cell ingression and, consequently,
the positioning of these cells along the forming anterior-posterior body axis
after gastrulation. Finally, we found that Hoxb genes control the timing of mesendoderm
ingression by regulating cellular bleb formation and cell surface fluctuations
in the ingressing cells. Collectively, our findings suggest that Hoxb genes interconnect
the temporal and spatial pattern of cell behaviors during zebrafish gastrulation
by controlling cell surface fluctuations.'
acknowledgement: We thank all the Heisenberg lab members for discussions and comments
on the manuscript, and the Bioimaging and Life Science facilities of ISTA for support
with microscopy and fish maintenance, respectively. This study was funded by a Japan
Society for the Promotion of Science (JSPS) Overseas Research Fellowship and a Japan
Science and Technology Agency PRESTO grant (JPMJPR214B) to Y.M. Open Access funding
provided by the Japan Science and Technology Agency. Deposited in PMC for immediate
release.
article_number: dev204261
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuuta
full_name: Moriyama, Yuuta
id: addc9b8c-67a0-11f0-b374-a2e094825470
last_name: Moriyama
orcid: 0000-0002-2853-8051
- first_name: Toshiyuki
full_name: Mitsui, Toshiyuki
last_name: Mitsui
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Moriyama Y, Mitsui T, Heisenberg C-PJ. Hoxb genes determine the timing of cell
ingression by regulating cell surface fluctuations during zebrafish gastrulation.
Development. 2025;152(12). doi:10.1242/dev.204261
apa: Moriyama, Y., Mitsui, T., & Heisenberg, C.-P. J. (2025). Hoxb genes determine
the timing of cell ingression by regulating cell surface fluctuations during zebrafish
gastrulation. Development. The Company of Biologists. https://doi.org/10.1242/dev.204261
chicago: Moriyama, Yuuta, Toshiyuki Mitsui, and Carl-Philipp J Heisenberg. “Hoxb
Genes Determine the Timing of Cell Ingression by Regulating Cell Surface Fluctuations
during Zebrafish Gastrulation.” Development. The Company of Biologists,
2025. https://doi.org/10.1242/dev.204261.
ieee: Y. Moriyama, T. Mitsui, and C.-P. J. Heisenberg, “Hoxb genes determine the
timing of cell ingression by regulating cell surface fluctuations during zebrafish
gastrulation,” Development, vol. 152, no. 12. The Company of Biologists,
2025.
ista: Moriyama Y, Mitsui T, Heisenberg C-PJ. 2025. Hoxb genes determine the timing
of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation.
Development. 152(12), dev204261.
mla: Moriyama, Yuuta, et al. “Hoxb Genes Determine the Timing of Cell Ingression
by Regulating Cell Surface Fluctuations during Zebrafish Gastrulation.” Development,
vol. 152, no. 12, dev204261, The Company of Biologists, 2025, doi:10.1242/dev.204261.
short: Y. Moriyama, T. Mitsui, C.-P.J. Heisenberg, Development 152 (2025).
corr_author: '1'
date_created: 2025-07-21T08:10:32Z
date_published: 2025-06-27T00:00:00Z
date_updated: 2025-09-30T14:07:51Z
day: '27'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1242/dev.204261
external_id:
isi:
- '001525252300001'
pmid:
- '40576478'
file:
- access_level: open_access
checksum: 808d8aa28df79d23fb661838d1fdc1be
content_type: application/pdf
creator: dernst
date_created: 2025-07-23T08:43:01Z
date_updated: 2025-07-23T08:43:01Z
file_id: '20070'
file_name: 2025_Development_Moriyama.pdf
file_size: 25935563
relation: main_file
success: 1
file_date_updated: 2025-07-23T08:43:01Z
has_accepted_license: '1'
intvolume: ' 152'
isi: 1
issue: '12'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Development
publication_identifier:
eissn:
- 1477-9129
issn:
- 0950-1991
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hoxb genes determine the timing of cell ingression by regulating cell surface
fluctuations during zebrafish gastrulation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 152
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20050'
abstract:
- lang: eng
text: We prove upper bounds on the L∞-Wasserstein distance from optimal transport
between strongly log-concave probability densities and log-Lipschitz perturbations.
In the simplest setting, such a bound amounts to a transport-information inequality
involving the L∞-Wasserstein metric and the relative L∞-Fisher information. We
show that this inequality can be sharpened significantly in situations where the
involved densities are anisotropic. Our proof is based on probabilistic techniques
using Langevin dynamics. As an application of these results, we obtain sharp exponential
rates of convergence in Fisher’s infinitesimal model from quantitative genetics,
generalising recent results by Calvez, Poyato, and Santambrogio in dimension 1
to arbitrary dimensions.
acknowledgement: This research was funded in part by the Austrian Science Fund (FWF)
project 10.55776/F65 and the Austrian Academy of Science, DOC fellowship nr. 26293.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Francesco
full_name: Pedrotti, Francesco
id: d3ac8ac6-dc8d-11ea-abe3-e2a9628c4c3c
last_name: Pedrotti
citation:
ama: Khudiakova K, Maas J, Pedrotti F. L∞-optimal transport of anisotropic log-concave
measures and exponential convergence in Fisher’s infinitesimal model. The Annals
of Applied Probability. 2025;35(3):1913-1940. doi:10.1214/25-aap2162
apa: Khudiakova, K., Maas, J., & Pedrotti, F. (2025). L∞-optimal transport of
anisotropic log-concave measures and exponential convergence in Fisher’s infinitesimal
model. The Annals of Applied Probability. Institute of Mathematical Statistics.
https://doi.org/10.1214/25-aap2162
chicago: Khudiakova, Kseniia, Jan Maas, and Francesco Pedrotti. “L∞-Optimal Transport
of Anisotropic Log-Concave Measures and Exponential Convergence in Fisher’s Infinitesimal
Model.” The Annals of Applied Probability. Institute of Mathematical Statistics,
2025. https://doi.org/10.1214/25-aap2162.
ieee: K. Khudiakova, J. Maas, and F. Pedrotti, “L∞-optimal transport of anisotropic
log-concave measures and exponential convergence in Fisher’s infinitesimal model,”
The Annals of Applied Probability, vol. 35, no. 3. Institute of Mathematical
Statistics, pp. 1913–1940, 2025.
ista: Khudiakova K, Maas J, Pedrotti F. 2025. L∞-optimal transport of anisotropic
log-concave measures and exponential convergence in Fisher’s infinitesimal model.
The Annals of Applied Probability. 35(3), 1913–1940.
mla: Khudiakova, Kseniia, et al. “L∞-Optimal Transport of Anisotropic Log-Concave
Measures and Exponential Convergence in Fisher’s Infinitesimal Model.” The
Annals of Applied Probability, vol. 35, no. 3, Institute of Mathematical Statistics,
2025, pp. 1913–40, doi:10.1214/25-aap2162.
short: K. Khudiakova, J. Maas, F. Pedrotti, The Annals of Applied Probability 35
(2025) 1913–1940.
corr_author: '1'
date_created: 2025-07-21T08:13:54Z
date_published: 2025-06-01T00:00:00Z
date_updated: 2025-09-30T14:12:48Z
day: '01'
department:
- _id: JaMa
doi: 10.1214/25-aap2162
external_id:
arxiv:
- '2402.04151'
isi:
- '001523520000012'
intvolume: ' 35'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2402.04151
month: '06'
oa: 1
oa_version: Preprint
page: 1913-1940
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
- _id: 34d33d68-11ca-11ed-8bc3-ec13763c0ca8
grant_number: '26293'
name: The impact of deleterious mutations on small populations
publication: The Annals of Applied Probability
publication_identifier:
issn:
- 1050-5164
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
related_material:
record:
- id: '17352'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: L∞-optimal transport of anisotropic log-concave measures and exponential convergence
in Fisher’s infinitesimal model
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 35
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20051'
abstract:
- lang: eng
text: "We revisit the majority problem in the population protocol communication
model, as first studied by Angluin et al. (Distributed Computing 2008). We consider
a more general version of this problem known as plurality consensus, which has
already been studied intensively in the literature. In this problem, each node
in a system of n nodes, has initially one of k different opinions, and they need
to agree on the (relative) majority opinion. In particular, we consider the important
and intensively studied model of Undecided State Dynamics.\r\nOur main contribution
is an almost tight lower bound on the stabilization time: we prove that there
exists an initial configuration, even with bias \\Delta = \\omega(\\sqrt{n\\log
n}), where stabilization requires \\Omega(kn\\log \\frac {\\sqrt n} {k \\log n})
interactions, or equivalently, \\Omega(k\\log \\frac {\\sqrt n} {k \\log n}) parallel
time for any k = o\\left(\\frac {\\sqrt n}{\\log n}\\right). This bound is tight
for any k \\le n^{\\frac 1 2 - \\epsilon}, where \\epsilon >0 can be any small
constant, as Amir et al.~(PODC'23) gave a O(k\\log n) parallel time upper bound
for k = O\\left(\\frac {\\sqrt n} {\\log ^2 n}\\right)."
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(MoDynStruct, No. 101019564) and the Austrian Science Fund (FWF) grant DOI 10.55776/I5862,grant
DOI 10.55776/I5982, and grant DOI 10.55776/P33775 with\r\nadditional funding from
the netidee SCIENCE Stiftung, 2020–2024\r\nand the German Research Foundation (DFG),
grant 470029389\r\n(FlexNets)."
article_processing_charge: Yes (via OA deal)
arxiv: 1
author:
- first_name: Antoine
full_name: El-Hayek, Antoine
id: 888a098e-fcac-11ee-aff7-d347be57b725
last_name: El-Hayek
orcid: 0000-0003-4268-7368
- first_name: Robert
full_name: Elsässer, Robert
last_name: Elsässer
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: 'El-Hayek A, Elsässer R, Schmid S. An almost tight lower bound for plurality
consensus with undecided state dynamics in the population protocol model. In:
Proceedings of the ACM Symposium on Principles of Distributed Computing.
Association for Computing Machinery; 2025. doi:10.1145/3732772.3733505'
apa: 'El-Hayek, A., Elsässer, R., & Schmid, S. (2025). An almost tight lower
bound for plurality consensus with undecided state dynamics in the population
protocol model. In Proceedings of the ACM Symposium on Principles of Distributed
Computing. Huatulco, Mexico: Association for Computing Machinery. https://doi.org/10.1145/3732772.3733505'
chicago: El-Hayek, Antoine, Robert Elsässer, and Stefan Schmid. “An Almost Tight
Lower Bound for Plurality Consensus with Undecided State Dynamics in the Population
Protocol Model.” In Proceedings of the ACM Symposium on Principles of Distributed
Computing. Association for Computing Machinery, 2025. https://doi.org/10.1145/3732772.3733505.
ieee: A. El-Hayek, R. Elsässer, and S. Schmid, “An almost tight lower bound for
plurality consensus with undecided state dynamics in the population protocol model,”
in Proceedings of the ACM Symposium on Principles of Distributed Computing,
Huatulco, Mexico, 2025.
ista: 'El-Hayek A, Elsässer R, Schmid S. 2025. An almost tight lower bound for plurality
consensus with undecided state dynamics in the population protocol model. Proceedings
of the ACM Symposium on Principles of Distributed Computing. PODC: Symposium on
Principles of Distributed Computing.'
mla: El-Hayek, Antoine, et al. “An Almost Tight Lower Bound for Plurality Consensus
with Undecided State Dynamics in the Population Protocol Model.” Proceedings
of the ACM Symposium on Principles of Distributed Computing, Association for
Computing Machinery, 2025, doi:10.1145/3732772.3733505.
short: A. El-Hayek, R. Elsässer, S. Schmid, in:, Proceedings of the ACM Symposium
on Principles of Distributed Computing, Association for Computing Machinery, 2025.
conference:
end_date: 2025-06-20
location: Huatulco, Mexico
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2025-06-16
corr_author: '1'
date_created: 2025-07-21T08:16:15Z
date_published: 2025-06-13T00:00:00Z
date_updated: 2025-10-16T13:08:45Z
day: '13'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3732772.3733505
ec_funded: 1
external_id:
arxiv:
- '2505.02765'
isi:
- '001525534800066'
file:
- access_level: open_access
checksum: 52976d226f3f691aa519d71c1c718fa5
content_type: application/pdf
creator: dernst
date_created: 2025-08-04T09:10:55Z
date_updated: 2025-08-04T09:10:55Z
file_id: '20115'
file_name: 2025_PODC_ElHayek.pdf
file_size: 2200347
relation: main_file
success: 1
file_date_updated: 2025-08-04T09:10:55Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
grant_number: I05982
name: Static and Dynamic Hierarchical Graph Decompositions
- _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe
grant_number: P33775
name: Fast Algorithms for a Reactive Network Layer
publication: Proceedings of the ACM Symposium on Principles of Distributed Computing
publication_identifier:
isbn:
- ' 9798400718854'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: An almost tight lower bound for plurality consensus with undecided state dynamics
in the population protocol model
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20052'
abstract:
- lang: eng
text: "This paper revisits a fundamental distributed computing problem in the population
protocol model. Provided n agents each starting with an input color in [k], the
relative majority problem asks to find the predominant color. In the population
protocol model, at each time step, a scheduler selects two agents that first learn
each other's states and then update their states based on what they learned.\r\nWe
present the Circles protocol that solves the relative majority problem with k3
states. It is always-correct under weakly fair scheduling. Not only does it improve
upon the best known upper bound of O(k7), but it also shows a strikingly simpler
design inspired by energy minimization in chemical settings."
acknowledgement: 'This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(MoDynStruct, No. 101019564) and the Austrian Science Fund (FWF) grant DOI 10.55776/I5982,
and grant DOI 10.55776/P33775 with additional funding from the netidee SCIENCE Stiftung,
2020–2024 and the German Research Foundation (DFG), grant 470029389 (FlexNets). '
article_processing_charge: No
author:
- first_name: Tom-Lukas
full_name: Breitkopf, Tom-Lukas
last_name: Breitkopf
- first_name: Julien
full_name: Dallot, Julien
last_name: Dallot
- first_name: Antoine
full_name: El-Hayek, Antoine
id: 888a098e-fcac-11ee-aff7-d347be57b725
last_name: El-Hayek
orcid: 0000-0003-4268-7368
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
citation:
ama: 'Breitkopf T-L, Dallot J, El-Hayek A, Schmid S. Brief announcement: Minimizing
energy solves relative majority with a cubic number of states in population protocols.
In: Proceedings of the ACM Symposium on Principles of Distributed Computing.
Association for Computing Machinery; 2025:549-552. doi:10.1145/3732772.3733512'
apa: 'Breitkopf, T.-L., Dallot, J., El-Hayek, A., & Schmid, S. (2025). Brief
announcement: Minimizing energy solves relative majority with a cubic number of
states in population protocols. In Proceedings of the ACM Symposium on Principles
of Distributed Computing (pp. 549–552). Huatulco, Mexico: Association for
Computing Machinery. https://doi.org/10.1145/3732772.3733512'
chicago: 'Breitkopf, Tom-Lukas, Julien Dallot, Antoine El-Hayek, and Stefan Schmid.
“Brief Announcement: Minimizing Energy Solves Relative Majority with a Cubic Number
of States in Population Protocols.” In Proceedings of the ACM Symposium on
Principles of Distributed Computing, 549–52. Association for Computing Machinery,
2025. https://doi.org/10.1145/3732772.3733512.'
ieee: 'T.-L. Breitkopf, J. Dallot, A. El-Hayek, and S. Schmid, “Brief announcement:
Minimizing energy solves relative majority with a cubic number of states in population
protocols,” in Proceedings of the ACM Symposium on Principles of Distributed
Computing, Huatulco, Mexico, 2025, pp. 549–552.'
ista: 'Breitkopf T-L, Dallot J, El-Hayek A, Schmid S. 2025. Brief announcement:
Minimizing energy solves relative majority with a cubic number of states in population
protocols. Proceedings of the ACM Symposium on Principles of Distributed Computing.
PODC: Symposium on Principles of Distributed Computing, 549–552.'
mla: 'Breitkopf, Tom-Lukas, et al. “Brief Announcement: Minimizing Energy Solves
Relative Majority with a Cubic Number of States in Population Protocols.” Proceedings
of the ACM Symposium on Principles of Distributed Computing, Association for
Computing Machinery, 2025, pp. 549–52, doi:10.1145/3732772.3733512.'
short: T.-L. Breitkopf, J. Dallot, A. El-Hayek, S. Schmid, in:, Proceedings of the
ACM Symposium on Principles of Distributed Computing, Association for Computing
Machinery, 2025, pp. 549–552.
conference:
end_date: 2025-06-20
location: Huatulco, Mexico
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2025-06-16
corr_author: '1'
date_created: 2025-07-21T08:17:04Z
date_published: 2025-06-13T00:00:00Z
date_updated: 2026-02-16T11:46:37Z
day: '13'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.1145/3732772.3733512
ec_funded: 1
external_id:
isi:
- '001525534800069'
file:
- access_level: open_access
checksum: e99679ffb28877b7cea4d54860302790
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T07:32:01Z
date_updated: 2025-08-05T07:32:01Z
file_id: '20123'
file_name: 2025_PODC_Breitkopf.pdf
file_size: 549706
relation: main_file
success: 1
file_date_updated: 2025-08-05T07:32:01Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 549-552
project:
- _id: bd9ca328-d553-11ed-ba76-dc4f890cfe62
call_identifier: H2020
grant_number: '101019564'
name: The design and evaluation of modern fully dynamic data structures
- _id: bda196b2-d553-11ed-ba76-8e8ee6c21103
grant_number: I05982
name: Static and Dynamic Hierarchical Graph Decompositions
- _id: bd9e3a2e-d553-11ed-ba76-8aa684ce17fe
grant_number: P33775
name: Fast Algorithms for a Reactive Network Layer
publication: Proceedings of the ACM Symposium on Principles of Distributed Computing
publication_identifier:
isbn:
- '9798400718854'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: 'Brief announcement: Minimizing energy solves relative majority with a cubic
number of states in population protocols'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '20053'
abstract:
- lang: eng
text: "Liquid democracy is a transitive vote delegation mechanism over voting graphs.
It enables each voter to delegate their vote(s) to another better-informed voter,
with the goal of collectively making a better decision. The question of whether
liquid democracy outperforms direct voting has been previously studied in the
context of local delegation mechanisms (where voters can only delegate to someone
in their neighbourhood) and binary decision problems. It has previously been shown
that it is impossible for local delegation mechanisms to outperform direct voting
in general graphs. This raises the question: for which classes of graphs do local
delegation mechanisms yield good results?\r\nIn this work, we analyse (1) properties
of specific graphs and (2) properties of local delegation mechanisms on these
graphs, determining where local delegation actually outperforms direct voting.
We show that a critical graph property enabling liquid democracy is that the voting
outcome of local delegation mechanisms preserves a sufficient amount of variance,
thereby avoiding situations where delegation falls behind direct voting1. These
insights allow us to prove our main results, namely that there exist local delegation
mechanisms that perform no worse and in fact quantitatively better than direct
voting in natural graph topologies like complete, random d-regular, and bounded
degree graphs, lending a more nuanced perspective to previous impossibility results."
acknowledgement: This work was partially supported by MOE-T2EP20122-0014 (DataDriven
Distributed Algorithms), German Research Foundation (DFG) project ReNO (SPP 2378)
from 2023-2027, ERC CoG 863818 (ForMSMArt) and Austrian Science Fund (FWF) 10.55776/COE12.
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Seth
full_name: Gilbert, Seth
last_name: Gilbert
- first_name: Stefan
full_name: Schmid, Stefan
last_name: Schmid
- first_name: Jakub
full_name: Svoboda, Jakub
id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
last_name: Svoboda
orcid: 0000-0002-1419-3267
- first_name: Michelle X
full_name: Yeo, Michelle X
id: 2D82B818-F248-11E8-B48F-1D18A9856A87
last_name: Yeo
orcid: 0009-0001-3676-4809
citation:
ama: 'Chatterjee K, Gilbert S, Schmid S, Svoboda J, Yeo MX. When is liquid democracy
possible?: On the manipulation of variance. In: Proceedings of the ACM Symposium
on Principles of Distributed Computing. Association for Computing Machinery;
2025:241-251. doi:10.1145/3732772.3733544'
apa: 'Chatterjee, K., Gilbert, S., Schmid, S., Svoboda, J., & Yeo, M. X. (2025).
When is liquid democracy possible?: On the manipulation of variance. In Proceedings
of the ACM Symposium on Principles of Distributed Computing (pp. 241–251).
Huatulco, Mexico: Association for Computing Machinery. https://doi.org/10.1145/3732772.3733544'
chicago: 'Chatterjee, Krishnendu, Seth Gilbert, Stefan Schmid, Jakub Svoboda, and
Michelle X Yeo. “When Is Liquid Democracy Possible?: On the Manipulation of Variance.”
In Proceedings of the ACM Symposium on Principles of Distributed Computing,
241–51. Association for Computing Machinery, 2025. https://doi.org/10.1145/3732772.3733544.'
ieee: 'K. Chatterjee, S. Gilbert, S. Schmid, J. Svoboda, and M. X. Yeo, “When is
liquid democracy possible?: On the manipulation of variance,” in Proceedings
of the ACM Symposium on Principles of Distributed Computing, Huatulco, Mexico,
2025, pp. 241–251.'
ista: 'Chatterjee K, Gilbert S, Schmid S, Svoboda J, Yeo MX. 2025. When is liquid
democracy possible?: On the manipulation of variance. Proceedings of the ACM Symposium
on Principles of Distributed Computing. PODC: Symposium on Principles of Distributed
Computing, 241–251.'
mla: 'Chatterjee, Krishnendu, et al. “When Is Liquid Democracy Possible?: On the
Manipulation of Variance.” Proceedings of the ACM Symposium on Principles of
Distributed Computing, Association for Computing Machinery, 2025, pp. 241–51,
doi:10.1145/3732772.3733544.'
short: K. Chatterjee, S. Gilbert, S. Schmid, J. Svoboda, M.X. Yeo, in:, Proceedings
of the ACM Symposium on Principles of Distributed Computing, Association for Computing
Machinery, 2025, pp. 241–251.
conference:
end_date: 2025-06-20
location: Huatulco, Mexico
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2025-06-16
corr_author: '1'
date_created: 2025-07-21T08:18:26Z
date_published: 2025-06-13T00:00:00Z
date_updated: 2026-02-16T11:46:51Z
day: '13'
ddc:
- '000'
department:
- _id: KrCh
- _id: KrPi
doi: 10.1145/3732772.3733544
ec_funded: 1
external_id:
isi:
- '001525534800030'
file:
- access_level: open_access
checksum: cd628fe54d96e9fc6cc789bb8145422b
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T07:15:31Z
date_updated: 2025-08-05T07:15:31Z
file_id: '20122'
file_name: 2025_PODC_Chatterjee.pdf
file_size: 783297
relation: main_file
success: 1
file_date_updated: 2025-08-05T07:15:31Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2025/745
month: '06'
oa: 1
oa_version: Published Version
page: 241-251
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the ACM Symposium on Principles of Distributed Computing
publication_identifier:
isbn:
- '9798400718854'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: 'When is liquid democracy possible?: On the manipulation of variance'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
_id: '20054'
article_number: '220'
article_processing_charge: No
author:
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
citation:
ama: 'Horta S. Solid state diffusion in metal-semiconductors core-shell nanoparticle.
In: Proceedings of the MATSUS Spring 2025 Conference. Fundació de la comunitat
valenciana SCITO; 2025. doi:10.29363/nanoge.matsusspring.2025.220'
apa: 'Horta, S. (2025). Solid state diffusion in metal-semiconductors core-shell
nanoparticle. In Proceedings of the MATSUS Spring 2025 Conference. Sevilla,
Spain: Fundació de la comunitat valenciana SCITO. https://doi.org/10.29363/nanoge.matsusspring.2025.220'
chicago: Horta, Sharona. “Solid State Diffusion in Metal-Semiconductors Core-Shell
Nanoparticle.” In Proceedings of the MATSUS Spring 2025 Conference. Fundació
de la comunitat valenciana SCITO, 2025. https://doi.org/10.29363/nanoge.matsusspring.2025.220.
ieee: S. Horta, “Solid state diffusion in metal-semiconductors core-shell nanoparticle,”
in Proceedings of the MATSUS Spring 2025 Conference, Sevilla, Spain, 2025.
ista: 'Horta S. 2025. Solid state diffusion in metal-semiconductors core-shell nanoparticle.
Proceedings of the MATSUS Spring 2025 Conference. MATSUS: Materials for Sustainable
Development Conference, 220.'
mla: Horta, Sharona. “Solid State Diffusion in Metal-Semiconductors Core-Shell Nanoparticle.”
Proceedings of the MATSUS Spring 2025 Conference, 220, Fundació de la comunitat
valenciana SCITO, 2025, doi:10.29363/nanoge.matsusspring.2025.220.
short: S. Horta, in:, Proceedings of the MATSUS Spring 2025 Conference, Fundació
de la comunitat valenciana SCITO, 2025.
conference:
end_date: 2025-03-07
location: Sevilla, Spain
name: 'MATSUS: Materials for Sustainable Development Conference'
start_date: 2025-03-03
corr_author: '1'
date_created: 2025-07-21T08:22:29Z
date_published: 2025-03-03T00:00:00Z
date_updated: 2025-09-23T09:04:03Z
day: '03'
department:
- _id: MaIb
doi: 10.29363/nanoge.matsusspring.2025.220
language:
- iso: eng
month: '03'
oa_version: None
publication: Proceedings of the MATSUS Spring 2025 Conference
publication_status: published
publisher: Fundació de la comunitat valenciana SCITO
quality_controlled: '1'
status: public
title: Solid state diffusion in metal-semiconductors core-shell nanoparticle
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_type: closed access
_id: '20055'
abstract:
- lang: eng
text: Supercrystals represent three-dimensional orderings of colloidal nanocrystals
(NCs), showcasing collective properties in photonics, phononics, and electronics
applications.1,2 Recent studies have shown that such assemblies are directly produced
during nanocrystal reactions.3–6 However, a fundamental understanding of in situ
formed supercrystals that withstand typical NC purification processes remains
underexplored, which is important for further use. Herein, we report the reaction
precursor-mediated formation of stable PbTe supercrystals. Rationalizing the formation
of these assemblies through small-angle x-ray scattering (SAXS) measurements,
we unveil their formation mechanism. Our findings reveal that the supercrystal
formation occurs in the presence of an excess of lead oleates in the crude solution.
It should be noted that the formed supercrystals can be stabilized under specific
conditions determined by the lead oleate cluster concentration, content of trioctylphosphine
telluride (TOP-Te), NC size and the need of an annealing step at mild conditions.
Furthermore, this approach allows for the continuous growth of a secondary phase
within the supercrystal; for example in the case of PbTe supercrystals, a PbS
shell can be grown on each PbTe NC constituent, resulting in core-shell PbTe-PbS
supercrystals. Our work elucidates that reaction precursors play an important
role in in situ SC formation and stabilization, implying the possibility of applying
this knowledge to other NC reactions.
acknowledged_ssus:
- _id: EM-Fac
- _id: NMR
- _id: LifeSc
acknowledgement: ISTA and the Werner Siemens Foundation financially supported this
work. The Scientific Service Units (SSU) of ISTA supported this research through
resources provided by the Electron Microscopy Facility (EMF), NMR Facility and the
Lab Support Facility (LSF).
article_number: '173'
article_processing_charge: No
author:
- first_name: Seungho
full_name: Lee, Seungho
id: BB243B88-D767-11E9-B658-BC13E6697425
last_name: Lee
orcid: 0000-0002-6962-8598
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Aiswarya
full_name: Rayaroth Puthiyaveettil, Aiswarya
id: 8aceb01b-8972-11ed-ae7b-d5fe53775add
last_name: Rayaroth Puthiyaveettil
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: 'Lee S, Balazs D, Horta S, Rayaroth Puthiyaveettil A, Ibáñez M. Reaction precursor-mediated
formation of stable supercrystals in colloidal nanocrystal synthesis: PbTe case.
In: Proceedings of the MATSUS Spring 2025 Conference. Fundació de la comunitat
valenciana SCITO; 2025. doi:10.29363/nanoge.matsusspring.2025.173'
apa: 'Lee, S., Balazs, D., Horta, S., Rayaroth Puthiyaveettil, A., & Ibáñez,
M. (2025). Reaction precursor-mediated formation of stable supercrystals in colloidal
nanocrystal synthesis: PbTe case. In Proceedings of the MATSUS Spring 2025
Conference. Sevilla, Spain: Fundació de la comunitat valenciana SCITO. https://doi.org/10.29363/nanoge.matsusspring.2025.173'
chicago: 'Lee, Seungho, Daniel Balazs, Sharona Horta, Aiswarya Rayaroth Puthiyaveettil,
and Maria Ibáñez. “Reaction Precursor-Mediated Formation of Stable Supercrystals
in Colloidal Nanocrystal Synthesis: PbTe Case.” In Proceedings of the MATSUS
Spring 2025 Conference. Fundació de la comunitat valenciana SCITO, 2025. https://doi.org/10.29363/nanoge.matsusspring.2025.173.'
ieee: 'S. Lee, D. Balazs, S. Horta, A. Rayaroth Puthiyaveettil, and M. Ibáñez, “Reaction
precursor-mediated formation of stable supercrystals in colloidal nanocrystal
synthesis: PbTe case,” in Proceedings of the MATSUS Spring 2025 Conference,
Sevilla, Spain, 2025.'
ista: 'Lee S, Balazs D, Horta S, Rayaroth Puthiyaveettil A, Ibáñez M. 2025. Reaction
precursor-mediated formation of stable supercrystals in colloidal nanocrystal
synthesis: PbTe case. Proceedings of the MATSUS Spring 2025 Conference. MATSUS:
Materials for Sustainable Development Conference, 173.'
mla: 'Lee, Seungho, et al. “Reaction Precursor-Mediated Formation of Stable Supercrystals
in Colloidal Nanocrystal Synthesis: PbTe Case.” Proceedings of the MATSUS Spring
2025 Conference, 173, Fundació de la comunitat valenciana SCITO, 2025, doi:10.29363/nanoge.matsusspring.2025.173.'
short: S. Lee, D. Balazs, S. Horta, A. Rayaroth Puthiyaveettil, M. Ibáñez, in:,
Proceedings of the MATSUS Spring 2025 Conference, Fundació de la comunitat valenciana
SCITO, 2025.
conference:
end_date: 2025-03-07
location: Sevilla, Spain
name: 'MATSUS: Materials for Sustainable Development Conference'
start_date: 2025-03-03
corr_author: '1'
date_created: 2025-07-21T08:33:20Z
date_published: 2025-03-15T00:00:00Z
date_updated: 2026-02-19T09:25:57Z
day: '15'
department:
- _id: MaIb
- _id: LifeSc
doi: 10.29363/nanoge.matsusspring.2025.173
language:
- iso: eng
month: '03'
oa_version: None
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Proceedings of the MATSUS Spring 2025 Conference
publication_status: published
publisher: Fundació de la comunitat valenciana SCITO
quality_controlled: '1'
status: public
title: 'Reaction precursor-mediated formation of stable supercrystals in colloidal
nanocrystal synthesis: PbTe case'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20056'
abstract:
- lang: eng
text: Theoretical studies have shown that stochasticity can affect the dynamics
of ecosystems in counterintuitive ways. However, without knowing the equations
governing the dynamics of populations or ecosystems, it is difficult to ascertain
the role of stochasticity in real datasets. Therefore, the inverse problem of
inferring the governing stochastic equations from datasets is important. Here,
we present an equation discovery methodology that takes time series data of state
variables as input and outputs a stochastic differential equation. We achieve
this by combining traditional approaches from stochastic calculus with the equation
discovery techniques. We demonstrate the generality of the method via several
applications. First, we deliberately choose various stochastic models with fundamentally
different governing equations, yet they produce nearly identical steady-state
distributions. We show that we can recover the correct underlying equations, and
thus infer the structure of their stability, accurately from the analysis of time
series data alone. We demonstrate our method on two real-world datasets—fish schooling
and single-cell migration—that have vastly different spatiotemporal scales and
dynamics. We illustrate various limitations and potential pitfalls of the method
and how to overcome them via diagnostic measures. Finally, we provide our open-source
code via a package named PyDaDDy (Python Library for Data-Driven Dynamics).
acknowledgement: V.G. acknowledges support from the Science and Engi-neering Research
Board, Department of Biotechnology,and the Indo-French Centre for the Promotion
of Ad-vanced Research (64T4-1). D.R.M. acknowledges supportfrom a Department of
Science and Technology (DST) In-novation in Science Pursuit for Inspired Research
(IN-SPIRE) Faculty Award. J.J. acknowledges support froma Humboldt postdoctoral
fellowship and the Heidelber-ger Akademie der Wissenschaften, Heidelberg, Germany.D.B.B.
acknowledges support from the NOMIS Founda-tion and an European Molecular Biology
Organization(EMBO) postdoctoral fellowship (ALTF 343-2022). A.N.and S.P. acknowledge
support from Ministry of Educa-tion (MoE) PhD fellowships. We thank Ashrit Mangal-wedhekar,
Vivek Jadhav, Shikhara Bhat, Cassandre Aimon,and Harishankar Muppirala for comments
on the manu-script and code. We thank Kollegala Sharma for his inputon the Kannada
translation of the title and abstract.Data-Driven Model Discovery E115
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Arshed
full_name: Nabeel, Arshed
last_name: Nabeel
- first_name: Ashwin
full_name: Karichannavar, Ashwin
last_name: Karichannavar
- first_name: Shuaib
full_name: Palathingal, Shuaib
last_name: Palathingal
- first_name: Jitesh
full_name: Jhawar, Jitesh
last_name: Jhawar
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Danny
full_name: Raj M, Danny
last_name: Raj M
- first_name: Vishwesha
full_name: Guttal, Vishwesha
last_name: Guttal
citation:
ama: Nabeel A, Karichannavar A, Palathingal S, et al. Discovering stochastic dynamical
equations from ecological time series data. The American Naturalist. 2025;205(4):E100-E117.
doi:10.1086/734083
apa: Nabeel, A., Karichannavar, A., Palathingal, S., Jhawar, J., Brückner, D., Raj
M, D., & Guttal, V. (2025). Discovering stochastic dynamical equations from
ecological time series data. The American Naturalist. University of Chicago
Press. https://doi.org/10.1086/734083
chicago: Nabeel, Arshed, Ashwin Karichannavar, Shuaib Palathingal, Jitesh Jhawar,
David Brückner, Danny Raj M, and Vishwesha Guttal. “Discovering Stochastic Dynamical
Equations from Ecological Time Series Data.” The American Naturalist. University
of Chicago Press, 2025. https://doi.org/10.1086/734083.
ieee: A. Nabeel et al., “Discovering stochastic dynamical equations from
ecological time series data,” The American Naturalist, vol. 205, no. 4.
University of Chicago Press, pp. E100–E117, 2025.
ista: Nabeel A, Karichannavar A, Palathingal S, Jhawar J, Brückner D, Raj M D, Guttal
V. 2025. Discovering stochastic dynamical equations from ecological time series
data. The American Naturalist. 205(4), E100–E117.
mla: Nabeel, Arshed, et al. “Discovering Stochastic Dynamical Equations from Ecological
Time Series Data.” The American Naturalist, vol. 205, no. 4, University
of Chicago Press, 2025, pp. E100–17, doi:10.1086/734083.
short: A. Nabeel, A. Karichannavar, S. Palathingal, J. Jhawar, D. Brückner, D. Raj
M, V. Guttal, The American Naturalist 205 (2025) E100–E117.
date_created: 2025-07-21T08:37:27Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2025-09-30T14:14:43Z
day: '01'
department:
- _id: EdHa
doi: 10.1086/734083
external_id:
arxiv:
- '2205.02645'
isi:
- '001433250500001'
pmid:
- '40179429'
intvolume: ' 205'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2205.02645
month: '04'
oa: 1
oa_version: Preprint
page: E100-E117
pmid: 1
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
grant_number: ALTF 343-2022
name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: The American Naturalist
publication_identifier:
eissn:
- 1537-5323
issn:
- 0003-0147
publication_status: published
publisher: University of Chicago Press
quality_controlled: '1'
related_material:
record:
- id: '20121'
relation: software
status: public
status: public
title: Discovering stochastic dynamical equations from ecological time series data
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 205
year: '2025'
...
---
OA_place: publisher
_id: '20074'
abstract:
- lang: eng
text: "Prenatal immune challenges pose significant risks to human embryonic brain
and eye development. However, we still lack knowledge about the safe usage of
anti-inflammatory drugs during pregnancy. Human induced pluripotent stem cell
(hIPSC)-derived brain organoid models provide a unique opportunity to investigate
neuronal development and have started to explore functional consequences upon
viral infection. However, brain organoids usually lack microglia, the brain-resident
immune cells. They are present in the early human embryonic brain and actively
participate in neuronal circuit development. At the same time, microglia are known
for their immune-sensing properties and will influence viral-mediated effects.
In my thesis, I was interested to study the multifunctional role of human microglia
during retinal development. \r\nIn chapter 1, I characterize the innate occurrence
of IBA1+-microglia-like cells within the retinal organoid differentiation (Bartalska
et al., 2022). Therefore, we differentiate hIPSC using an unguided retinal organoid
differentiation protocol and observe the presence of IBA1+-microglia-like cells
alongside retinal cups between week 3 and 4 in 2.5D culture. However, instead
of infiltrating the neuroectodermal sides, they enrich within non-pigmented, 3D-cystic
compartments that develop in low numbers parallel to 3D-retinal organoids. To
enrich for IBA1+-microglia precursors (preMG), we guided the differentiation with
a low-dosed BMP4 application, which prevents retinal cup development and enhances
microglia and 3D-cysts formation. We characterize the differentiated preMG for
their microglia-like identity and validated their functionality. In parallel,
mass spectrometry identifies the 3D-cysts to express mesenchymal and epithelial
markers. We confirm that comparable 3D-cysts are also the preferential environment
for IBA1+-microglia-like cells within the unguided retinal organoid differentiation.
\r\nIn chapter 2, I investigate how microglia influence retinal development and
whether they contribute to viral-mediated consequences (Schmied et al., 2025).
Here, we assemble preMG, which we have characterized in chapter 1, into 3D-retinal
organoids. Once the outer plexiform layer forms, microglia-like cells (iMG) populate
them and interact with retinal cell types. However, at this developmental stage,
the ganglion cell number decreases in 3D-retinal organoids. Thus, we adapted the
model into 2D which promotes their survival. Integrated iMG engulf ganglion cells
and control their cell number. In parallel, we apply the immunostimulant POLY(I:C)
to mimic a fetal viral infection. Although POLY(I:C) stimulation affects iMG phenotype,
it does not influence their interaction with ganglion cells. Furthermore, iMG
presence significantly contributes to the supernatant’s inflammatory secretome
and increases retinal cell proliferation. Simultaneous exposure to the non-steroidal
anti-inflammatory drug (NSAID) ibuprofen dampens POLY(I:C)-mediated consequences
of the iMG phenotype and ameliorates cell proliferation. Remarkably, while POLY(I:C)
disrupts neuronal calcium dynamics independent of iMG presence, ibuprofen rescues
this effect only in the presence of iMG. Mechanistically, ibuprofen blocks the
enzymes cyclooxygenase 1 and 2 (COX1/ PTGS1 and COX2/ PTGS2) simultaneously, from
which iMG predominantly express COX1. Selective inhibition of COX1 does not restore
the calcium peak amplitude upon POLY(I:C) stimulation, indicating ibuprofen’s
effect depends on the presence and interplay of both, COX1 and COX2. \r\nIn summary,
we characterized the 3D-retinal organoid model for the occurrence of IBA1+-microglia
like cells. As the innately developing IBA1+-cells enrich in mesenchymal over
retinal structures, we optimized a protocol to differentiate IBA1+-microglia precursors.
By combining these two models we generate microglia-assembled retinal organoids.
Our results underscore the importance of microglia during neurodevelopment, in
the context of prenatal immune challenges and provide insight into the mechanisms
by which ibuprofen exerts its protective effects during embryonic development."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Verena
full_name: Hübschmann, Verena
id: 32B7C918-F248-11E8-B48F-1D18A9856A87
last_name: Hübschmann
citation:
ama: Schmied V. Human microglia impact neuronal development in retinal organoids.
2025. doi:10.15479/AT-ISTA-20074
apa: Schmied, V. (2025). Human microglia impact neuronal development in retinal
organoids. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20074
chicago: Schmied, Verena. “ Human Microglia Impact Neuronal Development in Retinal
Organoids.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-20074.
ieee: V. Schmied, “ Human microglia impact neuronal development in retinal organoids,”
Institute of Science and Technology Austria, 2025.
ista: Schmied V. 2025. Human microglia impact neuronal development in retinal organoids.
Institute of Science and Technology Austria.
mla: Schmied, Verena. Human Microglia Impact Neuronal Development in Retinal
Organoids. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-20074.
short: V. Schmied, Human Microglia Impact Neuronal Development in Retinal Organoids,
Institute of Science and Technology Austria, 2025.
corr_author: '1'
date_created: 2025-07-24T12:37:22Z
date_published: 2025-07-24T00:00:00Z
date_updated: 2026-05-06T12:49:36Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/AT-ISTA-20074
file:
- access_level: closed
checksum: d09f9984002353ad7442358394919bf3
content_type: application/x-zip-compressed
creator: vhuebsch
date_created: 2025-07-30T08:47:53Z
date_updated: 2025-07-30T08:47:53Z
file_id: '20086'
file_name: PhD_Thesis_Schmied.zip
file_size: 43566093
relation: source_file
- access_level: open_access
checksum: 4833690d7283c587f518ba98eeb2c946
content_type: application/pdf
creator: vhuebsch
date_created: 2025-07-30T08:47:46Z
date_updated: 2025-07-30T09:29:09Z
file_id: '20087'
file_name: PhD_Thesis_Schmied.pdf
file_size: 13120922
relation: main_file
file_date_updated: 2025-07-30T09:29:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '151'
project:
- _id: 9B99D380-BA93-11EA-9121-9846C619BF3A
grant_number: SC19-017
name: How human microglia shape developing neurons during health and inflammation
publication_identifier:
isbn:
- 978-3-99078-060-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11478'
relation: part_of_dissertation
status: public
- id: '19593'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
title: ' Human microglia impact neuronal development in retinal organoids'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20077'
abstract:
- lang: eng
text: Hyaluronic acid (HA) is a key extracellular matrix component of vertebrates,
where it mediates cell adhesion, immune regulation, and tissue remodeling through
its interaction with specific receptors. Although HA has been detected in a few
invertebrate species, the lack of fundamental components of the molecular HA pathway
poses relevant objections about its functional role in these species. Mining genomic
and transcriptomic data, we considered the conservation of the gene locus encoding
for the extracellular link protein (XLINK) in marine mussels as well as its expression
patterns. Structural and phylogenetic analyses were undertaken to evaluate possible
similarities with vertebrate orthologs and to infer the origin of this gene in
invertebrates. Biochemical analysis was used to quantify HA in tissues of Mytilus
galloprovincialis. As a result, we confirm that the mussel can produce HA (up
to 1.02 ng/mg in mantle) and that its genome encodes two XLINK gene loci. These
loci are conserved in Mytilidae species and show a complex evolutionary path.
Mussel XLINK genes appeared to be expressed during developmental stages in three
mussel species, ranking in the top 100 expressed genes in M. trossulus at 17 h
post-fertilization. In conclusion, the presence of HA and an active gene with
the potential to bind HA suggests that mussels have the potential to synthesize
and use HA and are among the few invertebrates encoding this gene.
acknowledgement: 'This research was funded by the Italian Ministry of University and
Research (MIUR), grant ID: P2022JEEMT (Developing a tool for the study of haplotype
diversity in Mytilus galloprovincialis (HAMIGA)).'
article_number: '930'
article_processing_charge: Yes
article_type: original
author:
- first_name: Umberto
full_name: Rosani, Umberto
last_name: Rosani
- first_name: Nehir
full_name: Altan, Nehir
last_name: Altan
- first_name: Paola
full_name: Venier, Paola
last_name: Venier
- first_name: Enrico
full_name: Bortoletto, Enrico
last_name: Bortoletto
- first_name: Nicola
full_name: Volpi, Nicola
last_name: Volpi
- first_name: Carrie A
full_name: Bernecky, Carrie A
id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
last_name: Bernecky
orcid: 0000-0003-0893-7036
citation:
ama: Rosani U, Altan N, Venier P, Bortoletto E, Volpi N, Bernecky C. Ancestral origin
and functional expression of a hyaluronic acid pathway complement in mussels.
Biology. 2025;14(8). doi:10.3390/biology14080930
apa: Rosani, U., Altan, N., Venier, P., Bortoletto, E., Volpi, N., & Bernecky,
C. (2025). Ancestral origin and functional expression of a hyaluronic acid pathway
complement in mussels. Biology. MDPI. https://doi.org/10.3390/biology14080930
chicago: Rosani, Umberto, Nehir Altan, Paola Venier, Enrico Bortoletto, Nicola Volpi,
and Carrie Bernecky. “Ancestral Origin and Functional Expression of a Hyaluronic
Acid Pathway Complement in Mussels.” Biology. MDPI, 2025. https://doi.org/10.3390/biology14080930.
ieee: U. Rosani, N. Altan, P. Venier, E. Bortoletto, N. Volpi, and C. Bernecky,
“Ancestral origin and functional expression of a hyaluronic acid pathway complement
in mussels,” Biology, vol. 14, no. 8. MDPI, 2025.
ista: Rosani U, Altan N, Venier P, Bortoletto E, Volpi N, Bernecky C. 2025. Ancestral
origin and functional expression of a hyaluronic acid pathway complement in mussels.
Biology. 14(8), 930.
mla: Rosani, Umberto, et al. “Ancestral Origin and Functional Expression of a Hyaluronic
Acid Pathway Complement in Mussels.” Biology, vol. 14, no. 8, 930, MDPI,
2025, doi:10.3390/biology14080930.
short: U. Rosani, N. Altan, P. Venier, E. Bortoletto, N. Volpi, C. Bernecky, Biology
14 (2025).
date_created: 2025-07-25T08:28:26Z
date_published: 2025-07-24T00:00:00Z
date_updated: 2025-09-30T14:10:07Z
day: '24'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.3390/biology14080930
external_id:
isi:
- '001557922100001'
file:
- access_level: open_access
checksum: f5e059e66803fa54249c1db029aef0f6
content_type: application/pdf
creator: dernst
date_created: 2025-07-31T09:11:09Z
date_updated: 2025-07-31T09:11:09Z
file_id: '20097'
file_name: 2025_Biology_Rosani.pdf
file_size: 1885781
relation: main_file
success: 1
file_date_updated: 2025-07-31T09:11:09Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
issue: '8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Biology
publication_identifier:
issn:
- 2079-7737
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Ancestral origin and functional expression of a hyaluronic acid pathway complement
in mussels
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20078'
abstract:
- lang: eng
text: 'Let A be an abelian variety defined over a number field K, E/K be an elliptic
curve, and ϕ : A → Em be an isogeny defined over K. Let P ∈ A(K) be such that
ϕ(P)=(Q1,..., Qm) with RankZ(⟨Q1,...,Qm⟩)=1. We will study a divisibility sequence
related to the point P and show its relation with elliptic divisibility sequences.'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Stefan
full_name: Barańczuk, Stefan
last_name: Barańczuk
- first_name: Bartosz
full_name: Naskręcki, Bartosz
last_name: Naskręcki
- first_name: Matteo
full_name: Verzobio, Matteo
id: 7aa8f170-131e-11ed-88e1-a9efd01027cb
last_name: Verzobio
orcid: 0000-0002-0854-0306
citation:
ama: Barańczuk S, Naskręcki B, Verzobio M. Divisibility sequences related to abelian
varieties isogenous to a power of an elliptic curve. Journal of Number Theory.
2025;279:170-183. doi:10.1016/j.jnt.2025.06.001
apa: Barańczuk, S., Naskręcki, B., & Verzobio, M. (2025). Divisibility sequences
related to abelian varieties isogenous to a power of an elliptic curve. Journal
of Number Theory. Elsevier. https://doi.org/10.1016/j.jnt.2025.06.001
chicago: Barańczuk, Stefan, Bartosz Naskręcki, and Matteo Verzobio. “Divisibility
Sequences Related to Abelian Varieties Isogenous to a Power of an Elliptic Curve.”
Journal of Number Theory. Elsevier, 2025. https://doi.org/10.1016/j.jnt.2025.06.001.
ieee: S. Barańczuk, B. Naskręcki, and M. Verzobio, “Divisibility sequences related
to abelian varieties isogenous to a power of an elliptic curve,” Journal of
Number Theory, vol. 279. Elsevier, pp. 170–183, 2025.
ista: Barańczuk S, Naskręcki B, Verzobio M. 2025. Divisibility sequences related
to abelian varieties isogenous to a power of an elliptic curve. Journal of Number
Theory. 279, 170–183.
mla: Barańczuk, Stefan, et al. “Divisibility Sequences Related to Abelian Varieties
Isogenous to a Power of an Elliptic Curve.” Journal of Number Theory, vol.
279, Elsevier, 2025, pp. 170–83, doi:10.1016/j.jnt.2025.06.001.
short: S. Barańczuk, B. Naskręcki, M. Verzobio, Journal of Number Theory 279 (2025)
170–183.
corr_author: '1'
date_created: 2025-07-27T22:01:25Z
date_published: 2025-07-23T00:00:00Z
date_updated: 2026-06-18T18:19:48Z
day: '23'
ddc:
- '500'
department:
- _id: TiBr
doi: 10.1016/j.jnt.2025.06.001
external_id:
arxiv:
- '2309.09699'
isi:
- '001541172400002'
intvolume: ' 279'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.jnt.2025.06.001
month: '07'
oa: 1
oa_version: Published Version
page: 170-183
publication: Journal of Number Theory
publication_identifier:
issn:
- 0022-314X
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Divisibility sequences related to abelian varieties isogenous to a power of
an elliptic curve
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 279
year: '2025'
...
---
OA_type: closed access
_id: '20079'
abstract:
- lang: eng
text: "Research question: Is LINC01638 involved in regulation of epithelial-to-mesenchymal
transition (EMT) in endometriosis?\r\nDesign: A prospective patient cohort study
was combined with functional experiments in the 12Z endometriosis epithelial cell
line to investigate the role of LINC01638 in endometriosis. Eutopic endometrial
samples were collected by curettage, and ectopic endometrial lesion samples were
collected by laparoscopic surgery from 24 control patients and 41 patients with
endometriosis. The phenotype of 12Z cells was assessed following LINC01638 knockdown
using siRNA, performing proliferation, adhesion, migration and invasion assays,
as well as assessing apoptosis and cell cycle changes with flow cytometry assays.
In order to assess the relationship between LINC01638 and histone deacetylase
class 1 enzyme (HDAC1), LINC01638 knockdown was combined with HDAC inhibition
with the specific HDAC inhibitor romidepsin.\r\nResults: LINC01638 was up-regulated
in the epithelial layer of endometriotic lesions, and LINC01638 knockdown in 12Z
cells led to reduced proliferation, adhesion, migration and invasion. The reduction
in proliferation was associated with increased p21 and p27 expression, and G1
phase arrest. Further analysis of LINC01638 control and knockdown cells revealed
that a number of transcription factors associated with EMT are down-regulated
in knockdown cells, along with the cytoskeleton regulatory gene RHOB, while HDAC1
was up-regulated. Chromatin immunoprecipitation analysis and HDAC1 inhibitory
treatment combined with LINC01638 knockdown indicated that LINC01638 regulates
RHOB expression via HDAC1-mediated promoter deacetylation. RHOB is up-regulated
in the epithelial layer of endometriotic lesions compared with eutopic endometrium,
supporting a role in the disease.\r\nConclusions: LINC01638 is an epigenetic regulator
of the pathogenesis of endometriosis, promoting proliferation and EMT of endometriotic
lesions."
acknowledgement: "The authors wish to thank all the participants and health professionals
involved in this study. In addition, the authors wish to thank technical assistants
Barbara Widmar, Matthias Witzmann-Stern and Isabella Haslinger for their work assisting
with this study; and Simon Hippenmeyer for access to bioinformatic infrastructure
and resources.\r\nOpen access funding was provided by the Medical University of
Vienna."
article_number: '104942'
article_processing_charge: No
article_type: original
author:
- first_name: Iveta
full_name: Yotova, Iveta
last_name: Yotova
- first_name: Katharina
full_name: Proestling, Katharina
last_name: Proestling
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Lisa
full_name: Rainer, Lisa
last_name: Rainer
- first_name: Leonie
full_name: Kaup, Leonie
last_name: Kaup
- first_name: Jana
full_name: Heine, Jana
last_name: Heine
- first_name: Lejla
full_name: Sandrieser, Lejla
last_name: Sandrieser
- first_name: René
full_name: Wenzl, René
last_name: Wenzl
- first_name: Quanah J.
full_name: Hudson, Quanah J.
last_name: Hudson
citation:
ama: Yotova I, Proestling K, Pauler F, et al. LINC01638 promotes epithelial-to-mesenchymal
transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression.
Reproductive Biomedicine Online. 2025;51(3). doi:10.1016/j.rbmo.2025.104942
apa: Yotova, I., Proestling, K., Pauler, F., Rainer, L., Kaup, L., Heine, J., …
Hudson, Q. J. (2025). LINC01638 promotes epithelial-to-mesenchymal transition
in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression.
Reproductive Biomedicine Online. Elsevier. https://doi.org/10.1016/j.rbmo.2025.104942
chicago: Yotova, Iveta, Katharina Proestling, Florian Pauler, Lisa Rainer, Leonie
Kaup, Jana Heine, Lejla Sandrieser, René Wenzl, and Quanah J. Hudson. “LINC01638
Promotes Epithelial-to-Mesenchymal Transition in Endometriosis Epithelial Cells
by up-Regulating RHOB via HDAC1 Suppression.” Reproductive Biomedicine Online.
Elsevier, 2025. https://doi.org/10.1016/j.rbmo.2025.104942.
ieee: I. Yotova et al., “LINC01638 promotes epithelial-to-mesenchymal transition
in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression,”
Reproductive Biomedicine Online, vol. 51, no. 3. Elsevier, 2025.
ista: Yotova I, Proestling K, Pauler F, Rainer L, Kaup L, Heine J, Sandrieser L,
Wenzl R, Hudson QJ. 2025. LINC01638 promotes epithelial-to-mesenchymal transition
in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression.
Reproductive Biomedicine Online. 51(3), 104942.
mla: Yotova, Iveta, et al. “LINC01638 Promotes Epithelial-to-Mesenchymal Transition
in Endometriosis Epithelial Cells by up-Regulating RHOB via HDAC1 Suppression.”
Reproductive Biomedicine Online, vol. 51, no. 3, 104942, Elsevier, 2025,
doi:10.1016/j.rbmo.2025.104942.
short: I. Yotova, K. Proestling, F. Pauler, L. Rainer, L. Kaup, J. Heine, L. Sandrieser,
R. Wenzl, Q.J. Hudson, Reproductive Biomedicine Online 51 (2025).
date_created: 2025-07-27T22:01:25Z
date_published: 2025-07-17T00:00:00Z
date_updated: 2025-09-30T14:10:46Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.rbmo.2025.104942
external_id:
isi:
- '001549819000002'
pmid:
- '40680553'
intvolume: ' 51'
isi: 1
issue: '3'
language:
- iso: eng
month: '07'
oa_version: None
pmid: 1
publication: Reproductive Biomedicine Online
publication_identifier:
eissn:
- 1472-6491
issn:
- 1472-6483
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial
cells by up-regulating RHOB via HDAC1 suppression
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 51
year: '2025'
...