--- _id: '2409' abstract: - lang: eng text: "Background: The availability of many gene alignments with overlapping taxon sets raises the question of which strategy is the best to infer species phylogenies from multiple gene information. Methods and programs abound that use the gene alignment in different ways to reconstruct the species tree. In particular, different methods combine the original data at different points along the way from the underlying sequences to the final tree. Accordingly, they are classified into superalignment, supertree and medium-level approaches. Here, we present a simulation study to compare different methods from each of these three approaches.\r\n\r\nResults: We observe that superalignment methods usually outperform the other approaches over a wide range of parameters including sparse data and gene-specific evolutionary parameters. In the presence of high incongruency among gene trees, however, other combination methods show better performance than the superalignment approach. Surprisingly, some supertree and medium-level methods exhibit, on average, worse results than a single gene phylogeny with complete taxon information.\r\n\r\nConclusions: For some methods, using the reconstructed gene tree as an estimation of the species tree is superior to the combination of incomplete information. Superalignment usually performs best since it is less susceptible to stochastic error. Supertree methods can outperform superalignment in the presence of gene-tree conflict." acknowledgement: Financial support from the Wiener Wissenschafts-, Forschungs- and Technologiefonds (WWTF) is greatly appreciated. A.v.H. acknowledges support from the German Research Foundation (DFG, SPP-1174). article_number: '37' author: - first_name: Anne full_name: Kupczok, Anne id: 2BB22BC2-F248-11E8-B48F-1D18A9856A87 last_name: Kupczok - first_name: Heiko full_name: Schmidt, Heiko last_name: Schmidt - first_name: Arndt full_name: Von Haeseler, Arndt last_name: Von Haeseler citation: ama: Kupczok A, Schmidt H, Von Haeseler A. Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . Algorithms for Molecular Biology. 2010;5(1). doi:10.1186/1748-7188-5-37 apa: Kupczok, A., Schmidt, H., & Von Haeseler, A. (2010). Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . Algorithms for Molecular Biology. BioMed Central. https://doi.org/10.1186/1748-7188-5-37 chicago: Kupczok, Anne, Heiko Schmidt, and Arndt Von Haeseler. “Accuracy of Phylogeny Reconstruction Methods Combining Overlapping Gene Data Sets .” Algorithms for Molecular Biology. BioMed Central, 2010. https://doi.org/10.1186/1748-7188-5-37. ieee: A. Kupczok, H. Schmidt, and A. Von Haeseler, “Accuracy of phylogeny reconstruction methods combining overlapping gene data sets ,” Algorithms for Molecular Biology, vol. 5, no. 1. BioMed Central, 2010. ista: Kupczok A, Schmidt H, Von Haeseler A. 2010. Accuracy of phylogeny reconstruction methods combining overlapping gene data sets . Algorithms for Molecular Biology. 5(1), 37. mla: Kupczok, Anne, et al. “Accuracy of Phylogeny Reconstruction Methods Combining Overlapping Gene Data Sets .” Algorithms for Molecular Biology, vol. 5, no. 1, 37, BioMed Central, 2010, doi:10.1186/1748-7188-5-37. short: A. Kupczok, H. Schmidt, A. Von Haeseler, Algorithms for Molecular Biology 5 (2010). date_created: 2018-12-11T11:57:30Z date_published: 2010-12-06T00:00:00Z date_updated: 2021-01-12T06:57:18Z day: '06' ddc: - '576' department: - _id: JoBo doi: 10.1186/1748-7188-5-37 file: - access_level: open_access checksum: e2497285388bc4da629bafb46662eb43 content_type: application/pdf creator: system date_created: 2018-12-12T10:09:16Z date_updated: 2020-07-14T12:45:40Z file_id: '4739' file_name: IST-2018-939-v1+1_2010_Kupczok_Accuracy_of.pdf file_size: 723929 relation: main_file file_date_updated: 2020-07-14T12:45:40Z has_accepted_license: '1' intvolume: ' 5' issue: '1' language: - iso: eng month: '12' oa: 1 oa_version: Published Version publication: Algorithms for Molecular Biology publication_status: published publisher: BioMed Central publist_id: '4517' pubrep_id: '939' quality_controlled: '1' scopus_import: 1 status: public title: 'Accuracy of phylogeny reconstruction methods combining overlapping gene data sets ' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 5 year: '2010' ...