---
OA_place: publisher
_id: '837'
abstract:
- lang: eng
text: 'The hippocampus is a key brain region for memory and notably for spatial
memory, and is needed for both spatial working and reference memories. Hippocampal
place cells selectively discharge in specific locations of the environment to
form mnemonic represen tations of space. Several behavioral protocols have been
designed to test spatial memory which requires the experimental subject to utilize
working memory and reference memory. However, less is known about how these memory
traces are presented in the hippo campus, especially considering tasks that require
both spatial working and long -term reference memory demand. The aim of my thesis
was to elucidate how spatial working memory, reference memory, and the combination
of both are represented in the hippocampus. In this thesis, using a radial eight
-arm maze, I examined how the combined demand on these memories influenced place
cell assemblies while reference memories were partially updated by changing some
of the reward- arms. This was contrasted with task varian ts requiring working
or reference memories only. Reference memory update led to gradual place field
shifts towards the rewards on the switched arms. Cells developed enhanced firing
in passes between newly -rewarded arms as compared to those containing an unchanged
reward. The working memory task did not show such gradual changes. Place assemblies
on occasions replayed trajectories of the maze; at decision points the next arm
choice was preferentially replayed in tasks needing reference memory while in
the pure working memory task the previously visited arm was replayed. Hence trajectory
replay only reflected the decision of the animal in tasks needing reference memory
update. At the reward locations, in all three tasks outbound trajectories of the
current arm were preferentially replayed, showing the animals’ next path to the
center. At reward locations trajectories were replayed preferentially in reverse
temporal order. Moreover, in the center reverse replay was seen in the working
memory task but in the other tasks forward replay was seen. Hence, the direction
of reactivation was determined by the goal locations so that part of the trajectory
which was closer to the goal was reactivated later in an HSE while places further
away from the goal were reactivated earlier. Altogether my work demonstrated that
reference memory update triggers several levels of reorganization of the hippocampal
cognitive map which are not seen in simpler working memory demand s. Moreover,
hippocampus is likely to be involved in spatial decisions through reactivating
planned trajectories when reference memory recall is required for such a decision. '
acknowledgement: 'I am very grateful for the opportunity I have had as a graduate
student to explore and incredibly interesting branch of neuroscience, and for the
people who made it possible. Firstly, I would like to offer my thanks to my supervisor
Professor Jozsef Csicsvari for his great support, guidance and patience offered
over the years. The door to his office was always open whenever I had questions.
I have learned a lot from him about carefully designing experiments, asking interesting
questions and how to integrate results into a broader picture. I also express my
gratitude to the remarkable post- doc , Dr. Joseph O’Neill. He is a gre at scientific
role model who is always willing to teach , and advice and talk through problems
with his full attention. Many thanks to my wonderful “office mates” over the years
and their support and encouragement, Alice Avernhe, Philipp Schönenberger, Desiree
Dickerson, Karel Blahna, Charlotte Boccara, Igor Gridchyn, Peter Baracskay, Krisztián
Kovács, Dámaris Rangel, Karola Käfer and Federico Stella. They were the ones in
the lab for the many useful discussions about science and for making the laboratory
such a nice and friendly place to work in. A special thank goes to Michael LoBianco
and Jago Wallenschus for wonderful technical support. I would also like to thank
Professor Peter Jonas and Professor David M Bannerman for being my qualifying exam
and thesi s committee members despite their busy schedule. I am also very thankful
to IST Austria for their support all throughout my PhD. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Haibing
full_name: Xu, Haibing
id: 310349D0-F248-11E8-B48F-1D18A9856A87
last_name: Xu
citation:
ama: Xu H. Reactivation of the hippocampal cognitive map in goal-directed spatial
tasks. 2017. doi:10.15479/AT:ISTA:th_858
apa: Xu, H. (2017). Reactivation of the hippocampal cognitive map in goal-directed
spatial tasks. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_858
chicago: Xu, Haibing. “Reactivation of the Hippocampal Cognitive Map in Goal-Directed
Spatial Tasks.” Institute of Science and Technology Austria, 2017. https://doi.org/10.15479/AT:ISTA:th_858.
ieee: H. Xu, “Reactivation of the hippocampal cognitive map in goal-directed spatial
tasks,” Institute of Science and Technology Austria, 2017.
ista: Xu H. 2017. Reactivation of the hippocampal cognitive map in goal-directed
spatial tasks. Institute of Science and Technology Austria.
mla: Xu, Haibing. Reactivation of the Hippocampal Cognitive Map in Goal-Directed
Spatial Tasks. Institute of Science and Technology Austria, 2017, doi:10.15479/AT:ISTA:th_858.
short: H. Xu, Reactivation of the Hippocampal Cognitive Map in Goal-Directed Spatial
Tasks, Institute of Science and Technology Austria, 2017.
corr_author: '1'
date_created: 2018-12-11T11:48:46Z
date_published: 2017-08-23T00:00:00Z
date_updated: 2026-06-18T18:56:25Z
day: '23'
ddc:
- '571'
degree_awarded: PhD
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:th_858
file:
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checksum: f11925fbbce31e495124b6bc4f10573c
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-04-05T08:59:51Z
date_updated: 2020-07-14T12:48:12Z
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file_size: 3589490
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creator: dernst
date_created: 2019-04-05T08:59:51Z
date_updated: 2020-07-14T12:48:12Z
file_id: '6214'
file_name: 2017_Xu_Thesis_IST.pdf
file_size: 11668613
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file_date_updated: 2020-07-14T12:48:12Z
fulldoi: https://doi.org/10.15479/AT:ISTA:th_858
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '93'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6811'
pubrep_id: '858'
related_material:
record:
- id: '5828'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: Reactivation of the hippocampal cognitive map in goal-directed spatial tasks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2017'
...
---
_id: '993'
abstract:
- lang: eng
text: In real-world applications, observations are often constrained to a small
fraction of a system. Such spatial subsampling can be caused by the inaccessibility
or the sheer size of the system, and cannot be overcome by longer sampling. Spatial
subsampling can strongly bias inferences about a system’s aggregated properties.
To overcome the bias, we derive analytically a subsampling scaling framework that
is applicable to different observables, including distributions of neuronal avalanches,
of number of people infected during an epidemic outbreak, and of node degrees.
We demonstrate how to infer the correct distributions of the underlying full system,
how to apply it to distinguish critical from subcritical systems, and how to disentangle
subsampling and finite size effects. Lastly, we apply subsampling scaling to neuronal
avalanche models and to recordings from developing neural networks. We show that
only mature, but not young networks follow power-law scaling, indicating self-organization
to criticality during development.
article_number: '15140'
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Anna
full_name: Levina (Martius), Anna
id: 35AF8020-F248-11E8-B48F-1D18A9856A87
last_name: Levina (Martius)
- first_name: Viola
full_name: Priesemann, Viola
last_name: Priesemann
citation:
ama: Levina (Martius) A, Priesemann V. Subsampling scaling. Nature Communications.
2017;8. doi:10.1038/ncomms15140
apa: Levina (Martius), A., & Priesemann, V. (2017). Subsampling scaling. Nature
Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms15140
chicago: Levina (Martius), Anna, and Viola Priesemann. “Subsampling Scaling.” Nature
Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms15140.
ieee: A. Levina (Martius) and V. Priesemann, “Subsampling scaling,” Nature Communications,
vol. 8. Nature Publishing Group, 2017.
ista: Levina (Martius) A, Priesemann V. 2017. Subsampling scaling. Nature Communications.
8, 15140.
mla: Levina (Martius), Anna, and Viola Priesemann. “Subsampling Scaling.” Nature
Communications, vol. 8, 15140, Nature Publishing Group, 2017, doi:10.1038/ncomms15140.
short: A. Levina (Martius), V. Priesemann, Nature Communications 8 (2017).
date_created: 2018-12-11T11:49:35Z
date_published: 2017-05-04T00:00:00Z
date_updated: 2025-07-10T12:02:06Z
day: '04'
ddc:
- '005'
- '571'
department:
- _id: GaTk
- _id: JoCs
doi: 10.1038/ncomms15140
ec_funded: 1
external_id:
isi:
- '000400560700001'
file:
- access_level: open_access
checksum: 9880212f8c4c53404c7c6fbf9023c53a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:05Z
date_updated: 2020-07-14T12:48:19Z
file_id: '5122'
file_name: IST-2017-819-v1+1_2017_Levina_SubsamplingScaling.pdf
file_size: 746224
relation: main_file
file_date_updated: 2020-07-14T12:48:19Z
fulldoi: https://doi.org/10.1038/ncomms15140
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Nature Publishing Group
publist_id: '6406'
pubrep_id: '819'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Subsampling scaling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2017'
...
---
_id: '1279'
abstract:
- lang: eng
text: During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory
inputdriven neuronal firing patterns are replayed. Such replay is thought to be
important for plasticity- related processes and consolidation of memory traces.
It has previously been shown that the electrical stimulation-induced disruption
of SWR events interferes with learning in rodents in different experimental paradigms.
On the other hand, the cognitive map theory posits that the plastic changes of
the firing of hippocampal place cells constitute the electrophysiological counterpart
of the spatial learning, observable at the behavioral level. Therefore, we tested
whether intact SWR events occurring during the sleep/rest session after the first
exploration of a novel environment are needed for the stabilization of the CA1
code, which process requires plasticity. We found that the newly-formed representation
in the CA1 has the same level of stability with optogenetic SWR blockade as with
a control manipulation that delivered the same amount of light into the brain.
Therefore our results suggest that at least in the case of passive exploratory
behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles.
acknowledgement: 'The research leading to these results has received funding from
the People Programme (Marie Curie Actions) of the European Union''s Seventh Framework
Programme (FP7/2007-2013) under REA grant agreement n° [291734] via the IST FELLOWSHIP
awarded to Dr. Krisztián A. Kovács and the European Research Council starting grant
(acronym: HIPECMEM Project reference: 281511) awarded to Dr. Jozsef Csicsvari. We
thank Lauri Viljanto for technical help in building the ripple detector.'
article_number: e0164675
article_processing_charge: No
author:
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus.
PLoS One. 2016;11(10). doi:10.1371/journal.pone.0164675
apa: Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero,
D. K., & Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple
events in sleep does not interfere with the formation of stable spatial representation
in the CA1 area of the hippocampus. PLoS One. Public Library of Science.
https://doi.org/10.1371/journal.pone.0164675
chicago: Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen,
Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp
Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial
Representation in the CA1 Area of the Hippocampus.” PLoS One. Public Library
of Science, 2016. https://doi.org/10.1371/journal.pone.0164675.
ieee: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero,
and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep
does not interfere with the formation of stable spatial representation in the
CA1 area of the hippocampus,” PLoS One, vol. 11, no. 10. Public Library
of Science, 2016.
ista: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not
interfere with the formation of stable spatial representation in the CA1 area
of the hippocampus. PLoS One. 11(10), e0164675.
mla: Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events
in Sleep Does Not Interfere with the Formation of Stable Spatial Representation
in the CA1 Area of the Hippocampus.” PLoS One, vol. 11, no. 10, e0164675,
Public Library of Science, 2016, doi:10.1371/journal.pone.0164675.
short: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero,
J.L. Csicsvari, PLoS One 11 (2016).
corr_author: '1'
date_created: 2018-12-11T11:51:06Z
date_published: 2016-10-19T00:00:00Z
date_updated: 2025-09-22T08:36:27Z
day: '19'
ddc:
- '570'
- '571'
department:
- _id: JoCs
doi: 10.1371/journal.pone.0164675
ec_funded: 1
external_id:
isi:
- '000386204000043'
file:
- access_level: open_access
checksum: 395895ecb2216e9c39135abaa56b28b3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:26Z
date_updated: 2020-07-14T12:44:42Z
file_id: '5009'
file_name: IST-2016-690-v1+1_journal.pone.0164675.PDF
file_size: 4353592
relation: main_file
file_date_updated: 2020-07-14T12:44:42Z
fulldoi: https://doi.org/10.1371/journal.pone.0164675
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '6037'
pubrep_id: '690'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2016'
...
---
_id: '1334'
abstract:
- lang: eng
text: Hippocampal neurons encode a cognitive map of space. These maps are thought
to be updated during learning and in response to changes in the environment through
activity-dependent synaptic plasticity. Here we examine how changes in activity
influence spatial coding in rats using halorhodopsin-mediated, spatially selective
optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression
in many place cells and interneurons; some place cells increase their firing through
disinhibition, whereas some show no effect. We find that place fields of the unaffected
subpopulation remain stable. On the other hand, place fields of suppressed place
cells were unstable, showing remapping across sessions before and after optogenetic
inhibition. Disinhibited place cells had stable maps but sustained an elevated
firing rate. These findings suggest that place representation in the hippocampus
is constantly governed by activity-dependent processes, and that disinhibition
may provide a mechanism for rate remapping.
article_number: '11824'
article_processing_charge: No
author:
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Schönenberger P, O’Neill J, Csicsvari JL. Activity dependent plasticity of
hippocampal place maps. Nature Communications. 2016;7. doi:10.1038/ncomms11824
apa: Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2016). Activity dependent
plasticity of hippocampal place maps. Nature Communications. Nature Publishing
Group. https://doi.org/10.1038/ncomms11824
chicago: Schönenberger, Philipp, Joseph O’Neill, and Jozsef L Csicsvari. “Activity
Dependent Plasticity of Hippocampal Place Maps.” Nature Communications.
Nature Publishing Group, 2016. https://doi.org/10.1038/ncomms11824.
ieee: P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Activity dependent plasticity
of hippocampal place maps,” Nature Communications, vol. 7. Nature Publishing
Group, 2016.
ista: Schönenberger P, O’Neill J, Csicsvari JL. 2016. Activity dependent plasticity
of hippocampal place maps. Nature Communications. 7, 11824.
mla: Schönenberger, Philipp, et al. “Activity Dependent Plasticity of Hippocampal
Place Maps.” Nature Communications, vol. 7, 11824, Nature Publishing Group,
2016, doi:10.1038/ncomms11824.
short: P. Schönenberger, J. O’Neill, J.L. Csicsvari, Nature Communications 7 (2016).
corr_author: '1'
date_created: 2018-12-11T11:51:26Z
date_published: 2016-06-10T00:00:00Z
date_updated: 2025-09-22T08:20:24Z
day: '10'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1038/ncomms11824
ec_funded: 1
external_id:
isi:
- '000378007300001'
file:
- access_level: open_access
checksum: e43307754abe65b840a21939fe163618
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:10Z
date_updated: 2020-07-14T12:44:44Z
file_id: '5196'
file_name: IST-2016-660-v1+1_ncomms11824.pdf
file_size: 1793846
relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
fulldoi: https://doi.org/10.1038/ncomms11824
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5934'
pubrep_id: '660'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Activity dependent plasticity of hippocampal place maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 7
year: '2016'
...
---
_id: '1487'
abstract:
- lang: eng
text: Rhythms with time scales of multiple cycles per second permeate the mammalian
brain, yet neuroscientists are not certain of their functional roles. One leading
idea is that coherent oscillation between two brain regions facilitates the exchange
of information between them. In rats, the hippocampus and the vibrissal sensorimotor
system both are characterized by rhythmic oscillation in the theta range, 5–12
Hz. Previous work has been divided as to whether the two rhythms are independent
or coherent. To resolve this question, we acquired three measures from rats—whisker
motion, hippocampal local field potential (LFP), and barrel cortex unit firing—during
a whisker-mediated texture discrimination task and during control conditions (not
engaged in a whisker-mediated memory task). Compared to control conditions, the
theta band of hippocampal LFP showed a marked increase in power as the rats approached
and then palpated the texture. Phase synchronization between whisking and hippocampal
LFP increased by almost 50% during approach and texture palpation. In addition,
a greater proportion of barrel cortex neurons showed firing that was phase-locked
to hippocampal theta while rats were engaged in the discrimination task. Consistent
with a behavioral consequence of phase synchronization, the rats identified the
texture more rapidly and with lower error likelihood on trials in which there
was an increase in theta-whisking coherence at the moment of texture palpation.
These results suggest that coherence between the whisking rhythm, barrel cortex
firing, and hippocampal LFP is augmented selectively during epochs in which the
rat collects sensory information and that such coherence enhances the efficiency
of integration of stimulus information into memory and decision-making centers.
acknowledgement: We thank Eric Maris, Demian Battaglia, and Rodrigo Quian Quiroga
for useful discussions. We are grateful to Fabrizio Manzino and Marco Gigante for
construction of the behavioral apparatus, Igor Perkon for developing custom whisker
tracking software and to Francesca Pulecchi for animal care and histological processing.
article_number: e1002384
article_processing_charge: No
author:
- first_name: Natalia
full_name: Grion, Natalia
last_name: Grion
- first_name: Athena
full_name: Akrami, Athena
last_name: Akrami
- first_name: Yangfang
full_name: Zuo, Yangfang
last_name: Zuo
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Mathew
full_name: Diamond, Mathew
last_name: Diamond
citation:
ama: Grion N, Akrami A, Zuo Y, Stella F, Diamond M. Coherence between rat sensorimotor
system and hippocampus is enhanced during tactile discrimination. PLoS Biology.
2016;14(2). doi:10.1371/journal.pbio.1002384
apa: Grion, N., Akrami, A., Zuo, Y., Stella, F., & Diamond, M. (2016). Coherence
between rat sensorimotor system and hippocampus is enhanced during tactile discrimination.
PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.1002384
chicago: Grion, Natalia, Athena Akrami, Yangfang Zuo, Federico Stella, and Mathew
Diamond. “Coherence between Rat Sensorimotor System and Hippocampus Is Enhanced
during Tactile Discrimination.” PLoS Biology. Public Library of Science,
2016. https://doi.org/10.1371/journal.pbio.1002384.
ieee: N. Grion, A. Akrami, Y. Zuo, F. Stella, and M. Diamond, “Coherence between
rat sensorimotor system and hippocampus is enhanced during tactile discrimination,”
PLoS Biology, vol. 14, no. 2. Public Library of Science, 2016.
ista: Grion N, Akrami A, Zuo Y, Stella F, Diamond M. 2016. Coherence between rat
sensorimotor system and hippocampus is enhanced during tactile discrimination.
PLoS Biology. 14(2), e1002384.
mla: Grion, Natalia, et al. “Coherence between Rat Sensorimotor System and Hippocampus
Is Enhanced during Tactile Discrimination.” PLoS Biology, vol. 14, no.
2, e1002384, Public Library of Science, 2016, doi:10.1371/journal.pbio.1002384.
short: N. Grion, A. Akrami, Y. Zuo, F. Stella, M. Diamond, PLoS Biology 14 (2016).
date_created: 2018-12-11T11:52:18Z
date_published: 2016-02-18T00:00:00Z
date_updated: 2025-09-18T11:30:07Z
day: '18'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1371/journal.pbio.1002384
external_id:
isi:
- '000371883600015'
file:
- access_level: open_access
checksum: 3a5ce0d4e4e36bd6ceb4be761f85644a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:11Z
date_updated: 2020-07-14T12:44:57Z
file_id: '5129'
file_name: IST-2016-518-v1+1_journal.pbio.1002384.PDF
file_size: 2879899
relation: main_file
file_date_updated: 2020-07-14T12:44:57Z
fulldoi: https://doi.org/10.1371/journal.pbio.1002384
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '5700'
pubrep_id: '518'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coherence between rat sensorimotor system and hippocampus is enhanced during
tactile discrimination
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 14
year: '2016'
...
---
OA_place: repository
OA_type: green
_id: '1663'
abstract:
- lang: eng
text: CREB-binding protein (CBP) and p300 are transcriptional coactivators involved
in numerous biological processes that affect cell growth, transformation, differentiation,
and development. In this study, we provide evidence of the involvement of homeodomain-interacting
protein kinase 2 (HIPK2) in the regulation of CBP activity. We show that HIPK2
interacts with and phosphorylates several regions of CBP. We demonstrate that
serines 2361, 2363, 2371, 2376, and 2381 are responsible for the HIPK2-induced
mobility shift of CBP C-terminal activation domain. Moreover, we show that HIPK2
strongly potentiates the transcriptional activity of CBP. However, our data suggest
that HIPK2 activates CBP mainly by counteracting the repressive action of cell
cycle regulatory domain 1 (CRD1), located between amino acids 977 and 1076, independently
of CBP phosphorylation. Our findings thus highlight a complex regulation of CBP
activity by HIPK2, which might be relevant for the control of specific sets of
target genes involved in cellular proliferation, differentiation and apoptosis.
acknowledgement: 'We thank Silvia Soddu for the pCMV-HIPK2-FLAG expression vector.
This work was supported by Swiss National Science Foundation Grants 3100A0-105773,
3100A0-120699, and 31003A-135692 to J-R. C., and partly by an IST Fellowship awarded
to K. A. K. (Project: P IST EU01 under REA grant agreement n ° 291734).'
article_processing_charge: No
author:
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
- first_name: Myriam
full_name: Steinmann, Myriam
last_name: Steinmann
- first_name: Olivier
full_name: Halfon, Olivier
last_name: Halfon
- first_name: Pierre
full_name: Magistretti, Pierre
last_name: Magistretti
- first_name: Jean
full_name: Cardinaux, Jean
last_name: Cardinaux
citation:
ama: Kovács K, Steinmann M, Halfon O, Magistretti P, Cardinaux J. Complex regulation
of CREB-binding protein by homeodomain-interacting protein kinase 2. Cellular
Signalling. 2015;27(11):2252-2260. doi:10.1016/j.cellsig.2015.08.001
apa: Kovács, K., Steinmann, M., Halfon, O., Magistretti, P., & Cardinaux, J.
(2015). Complex regulation of CREB-binding protein by homeodomain-interacting
protein kinase 2. Cellular Signalling. Elsevier. https://doi.org/10.1016/j.cellsig.2015.08.001
chicago: Kovács, Krisztián, Myriam Steinmann, Olivier Halfon, Pierre Magistretti,
and Jean Cardinaux. “Complex Regulation of CREB-Binding Protein by Homeodomain-Interacting
Protein Kinase 2.” Cellular Signalling. Elsevier, 2015. https://doi.org/10.1016/j.cellsig.2015.08.001.
ieee: K. Kovács, M. Steinmann, O. Halfon, P. Magistretti, and J. Cardinaux, “Complex
regulation of CREB-binding protein by homeodomain-interacting protein kinase 2,”
Cellular Signalling, vol. 27, no. 11. Elsevier, pp. 2252–2260, 2015.
ista: Kovács K, Steinmann M, Halfon O, Magistretti P, Cardinaux J. 2015. Complex
regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.
Cellular Signalling. 27(11), 2252–2260.
mla: Kovács, Krisztián, et al. “Complex Regulation of CREB-Binding Protein by Homeodomain-Interacting
Protein Kinase 2.” Cellular Signalling, vol. 27, no. 11, Elsevier, 2015,
pp. 2252–60, doi:10.1016/j.cellsig.2015.08.001.
short: K. Kovács, M. Steinmann, O. Halfon, P. Magistretti, J. Cardinaux, Cellular
Signalling 27 (2015) 2252–2260.
corr_author: '1'
date_created: 2018-12-11T11:53:20Z
date_published: 2015-11-01T00:00:00Z
date_updated: 2025-09-23T08:19:10Z
day: '01'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.cellsig.2015.08.001
ec_funded: 1
external_id:
isi:
- '000361777500012'
pmid:
- '26247811'
file:
- access_level: open_access
checksum: 4ee690b6444b7a43523237f0941457d1
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:03Z
date_updated: 2025-06-26T06:47:23Z
file_id: '5321'
file_name: IST-2016-578-v1+1_CLS-D-15-00072R1_.pdf
file_size: 1735337
relation: main_file
file_date_updated: 2025-06-26T06:47:23Z
fulldoi: https://doi.org/10.1016/j.cellsig.2015.08.001
has_accepted_license: '1'
intvolume: ' 27'
isi: 1
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '11'
oa: 1
oa_version: Submitted Version
page: 2252 - 2260
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Cellular Signalling
publication_status: published
publisher: Elsevier
publist_id: '5487'
pubrep_id: '578'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Complex regulation of CREB-binding protein by homeodomain-interacting protein
kinase 2
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 27
year: '2015'
...
---
_id: '1874'
abstract:
- lang: eng
text: 'The hippocampal region, comprising the hippocampal formation and the parahippocampal
region, has been one of the most intensively studied parts of the brain for decades.
Better understanding of its functional diversity and complexity has led to an
increased demand for specificity in experimental procedures and manipulations.
In view of the complex 3D structure of the hippocampal region, precisely positioned
experimental approaches require a fine-grained architectural description that
is available and readable to experimentalists lacking detailed anatomical experience.
In this paper, we provide the first cyto- and chemoarchitectural description of
the hippocampal formation and parahippocampal region in the rat at high resolution
and in the three standard sectional planes: coronal, horizontal and sagittal.
The atlas uses a series of adjacent sections stained for neurons and for a number
of chemical marker substances, particularly parvalbumin and calbindin. All the
borders defined in one plane have been cross-checked against their counterparts
in the other two planes. The entire dataset will be made available as a web-based
interactive application through the Rodent Brain WorkBench (http://www.rbwb.org)
which, together with this paper, provides a unique atlas resource.'
article_processing_charge: No
author:
- first_name: Charlotte
full_name: Boccara, Charlotte
id: 3FC06552-F248-11E8-B48F-1D18A9856A87
last_name: Boccara
orcid: 0000-0001-7237-5109
- first_name: Lisa
full_name: Kjønigsen, Lisa
last_name: Kjønigsen
- first_name: Ingvild
full_name: Hammer, Ingvild
last_name: Hammer
- first_name: Jan
full_name: Bjaalie, Jan
last_name: Bjaalie
- first_name: Trygve
full_name: Leergaard, Trygve
last_name: Leergaard
- first_name: Menno
full_name: Witter, Menno
last_name: Witter
citation:
ama: Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. A three-plane
architectonic atlas of the rat hippocampal region. Hippocampus. 2015;25(7):838-857.
doi:10.1002/hipo.22407
apa: Boccara, C. N., Kjønigsen, L., Hammer, I., Bjaalie, J., Leergaard, T., &
Witter, M. (2015). A three-plane architectonic atlas of the rat hippocampal region.
Hippocampus. Wiley. https://doi.org/10.1002/hipo.22407
chicago: Boccara, Charlotte N., Lisa Kjønigsen, Ingvild Hammer, Jan Bjaalie, Trygve
Leergaard, and Menno Witter. “A Three-Plane Architectonic Atlas of the Rat Hippocampal
Region.” Hippocampus. Wiley, 2015. https://doi.org/10.1002/hipo.22407.
ieee: C. N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, and M. Witter,
“A three-plane architectonic atlas of the rat hippocampal region,” Hippocampus,
vol. 25, no. 7. Wiley, pp. 838–857, 2015.
ista: Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. 2015.
A three-plane architectonic atlas of the rat hippocampal region. Hippocampus.
25(7), 838–857.
mla: Boccara, Charlotte N., et al. “A Three-Plane Architectonic Atlas of the Rat
Hippocampal Region.” Hippocampus, vol. 25, no. 7, Wiley, 2015, pp. 838–57,
doi:10.1002/hipo.22407.
short: C.N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, M. Witter,
Hippocampus 25 (2015) 838–857.
date_created: 2018-12-11T11:54:29Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2025-09-23T07:29:29Z
day: '01'
department:
- _id: JoCs
doi: 10.1002/hipo.22407
external_id:
isi:
- '000356812700007'
fulldoi: https://doi.org/10.1002/hipo.22407
intvolume: ' 25'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 838 - 857
publication: Hippocampus
publication_status: published
publisher: Wiley
publist_id: '5222'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A three-plane architectonic atlas of the rat hippocampal region
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 25
year: '2015'
...
---
OA_type: closed access
_id: '19994'
abstract:
- lang: eng
text: Firing patterns of hippocampal principal cells are thought to participate
in the formation of mnemonic representations of place, which ultimately can be
used to guide the behavior of animals in space. Past studies have suggested that
place-selective activity in the hippocampus can emphasize the representation of
discrete locations associated with a strong behavioral salience. In the first
part of this book chapter, we review work that has described how that hippocampal
neuronal activity patterns reorganize during spatial learning. These studies revealed
that new hippocampal maps emerge during spatial learning to represent the location
of goal locations and demonstrated that, during recall, the reinstatement of these
maps predicts successful memory performance. In the second part of this chapter,
we discuss the role of sleep in memory consolidation in the context of goal-oriented
spatial learning. We summarize work that has demonstrated the replay of goal-oriented
neuronal assembly patterns that predict subsequent memory recall. Moreover, we
argue that the initial strengthening of new maps may in fact take place during
learning, triggered by waking sharp-wave/ripple patterns occurring at goal locations.
These reviewed studies highlight that the reorganization and replay of place cell
firing patterns might constitute a circuit signature for the expression of newly
acquired hippocampal engrams.
alternative_title:
- Springer Series in Computational Neuroscience
article_processing_charge: No
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'Dupret D, Csicsvari JL. Reorganization of Hippocampal Place-Selective Patterns
During Goal-Directed Learning and Their Reactivation During Sleep. In: Analysis
and Modeling of Coordinated Multi-Neuronal Activity. Vol 12. NEUROSCI. Springer
Nature; 2014. doi:10.1007/978-1-4939-1969-7_6'
apa: Dupret, D., & Csicsvari, J. L. (2014). Reorganization of Hippocampal Place-Selective
Patterns During Goal-Directed Learning and Their Reactivation During Sleep. In
Analysis and Modeling of Coordinated Multi-neuronal Activity (Vol. 12).
Springer Nature. https://doi.org/10.1007/978-1-4939-1969-7_6
chicago: Dupret, David, and Jozsef L Csicsvari. “Reorganization of Hippocampal Place-Selective
Patterns During Goal-Directed Learning and Their Reactivation During Sleep.” In
Analysis and Modeling of Coordinated Multi-Neuronal Activity, Vol. 12.
NEUROSCI. Springer Nature, 2014. https://doi.org/10.1007/978-1-4939-1969-7_6.
ieee: D. Dupret and J. L. Csicsvari, “Reorganization of Hippocampal Place-Selective
Patterns During Goal-Directed Learning and Their Reactivation During Sleep,” in
Analysis and Modeling of Coordinated Multi-neuronal Activity, vol. 12,
Springer Nature, 2014.
ista: 'Dupret D, Csicsvari JL. 2014.Reorganization of Hippocampal Place-Selective
Patterns During Goal-Directed Learning and Their Reactivation During Sleep. In:
Analysis and Modeling of Coordinated Multi-neuronal Activity. Springer Series
in Computational Neuroscience, vol. 12.'
mla: Dupret, David, and Jozsef L. Csicsvari. “Reorganization of Hippocampal Place-Selective
Patterns During Goal-Directed Learning and Their Reactivation During Sleep.” Analysis
and Modeling of Coordinated Multi-Neuronal Activity, vol. 12, Springer Nature,
2014, doi:10.1007/978-1-4939-1969-7_6.
short: D. Dupret, J.L. Csicsvari, in:, Analysis and Modeling of Coordinated Multi-Neuronal
Activity, Springer Nature, 2014.
date_created: 2025-07-10T14:06:05Z
date_published: 2014-10-30T00:00:00Z
date_updated: 2025-09-23T09:36:44Z
day: '30'
department:
- _id: JoCs
doi: 10.1007/978-1-4939-1969-7_6
fulldoi: https://doi.org/10.1007/978-1-4939-1969-7_6
intvolume: ' 12'
language:
- iso: eng
month: '10'
oa_version: None
publication: Analysis and Modeling of Coordinated Multi-neuronal Activity
publication_identifier:
eisbn:
- '9781493919697'
eissn:
- 2197-1919
isbn:
- '9781493919680'
issn:
- 2197-1900
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NEUROSCI
status: public
title: Reorganization of Hippocampal Place-Selective Patterns During Goal-Directed
Learning and Their Reactivation During Sleep
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2014'
...
---
_id: '2003'
abstract:
- lang: eng
text: Learning can be facilitated by previous knowledge when it is organized into
relational representations forming schemas. In this issue of Neuron, McKenzie
et al. (2014) demonstrate that the hippocampus rapidly forms interrelated, hierarchical
memory representations to support schema-based learning.
article_processing_charge: No
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Csicsvari JL. Learning by example in the hippocampus. Neuron.
2014;83(1):8-10. doi:10.1016/j.neuron.2014.06.013
apa: O’Neill, J., & Csicsvari, J. L. (2014). Learning by example in the hippocampus.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.06.013
chicago: O’Neill, Joseph, and Jozsef L Csicsvari. “Learning by Example in the Hippocampus.”
Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.06.013.
ieee: J. O’Neill and J. L. Csicsvari, “Learning by example in the hippocampus,”
Neuron, vol. 83, no. 1. Elsevier, pp. 8–10, 2014.
ista: O’Neill J, Csicsvari JL. 2014. Learning by example in the hippocampus. Neuron.
83(1), 8–10.
mla: O’Neill, Joseph, and Jozsef L. Csicsvari. “Learning by Example in the Hippocampus.”
Neuron, vol. 83, no. 1, Elsevier, 2014, pp. 8–10, doi:10.1016/j.neuron.2014.06.013.
short: J. O’Neill, J.L. Csicsvari, Neuron 83 (2014) 8–10.
corr_author: '1'
date_created: 2018-12-11T11:55:09Z
date_published: 2014-07-02T00:00:00Z
date_updated: 2025-09-29T12:03:17Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2014.06.013
external_id:
isi:
- '000340476800004'
fulldoi: https://doi.org/10.1016/j.neuron.2014.06.013
intvolume: ' 83'
isi: 1
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 8 - 10
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5073'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning by example in the hippocampus
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 83
year: '2014'
...
---
_id: '2004'
abstract:
- lang: eng
text: We have assembled a network of cell-fate determining transcription factors
that play a key role in the specification of the ventral neuronal subtypes of
the spinal cord on the basis of published transcriptional interactions. Asynchronous
Boolean modelling of the network was used to compare simulation results with reported
experimental observations. Such comparison highlighted the need to include additional
regulatory connections in order to obtain the fixed point attractors of the model
associated with the five known progenitor cell types located in the ventral spinal
cord. The revised gene regulatory network reproduced previously observed cell
state switches between progenitor cells observed in knock-out animal models or
in experiments where the transcription factors were overexpressed. Furthermore
the network predicted the inhibition of Irx3 by Nkx2.2 and this prediction was
tested experimentally. Our results provide evidence for the existence of an as
yet undescribed inhibitory connection which could potentially have significance
beyond the ventral spinal cord. The work presented in this paper demonstrates
the strength of Boolean modelling for identifying gene regulatory networks.
article_number: e111430
article_processing_charge: No
author:
- first_name: Anna
full_name: Lovrics, Anna
last_name: Lovrics
- first_name: Yu
full_name: Gao, Yu
last_name: Gao
- first_name: Bianka
full_name: Juhász, Bianka
last_name: Juhász
- first_name: István
full_name: Bock, István
last_name: Bock
- first_name: Helen
full_name: Byrne, Helen
last_name: Byrne
- first_name: András
full_name: Dinnyés, András
last_name: Dinnyés
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
citation:
ama: Lovrics A, Gao Y, Juhász B, et al. Boolean modelling reveals new regulatory
connections between transcription factors orchestrating the development of the
ventral spinal cord. PLoS One. 2014;9(11). doi:10.1371/journal.pone.0111430
apa: Lovrics, A., Gao, Y., Juhász, B., Bock, I., Byrne, H., Dinnyés, A., & Kovács,
K. (2014). Boolean modelling reveals new regulatory connections between transcription
factors orchestrating the development of the ventral spinal cord. PLoS One.
Public Library of Science. https://doi.org/10.1371/journal.pone.0111430
chicago: Lovrics, Anna, Yu Gao, Bianka Juhász, István Bock, Helen Byrne, András
Dinnyés, and Krisztián Kovács. “Boolean Modelling Reveals New Regulatory Connections
between Transcription Factors Orchestrating the Development of the Ventral Spinal
Cord.” PLoS One. Public Library of Science, 2014. https://doi.org/10.1371/journal.pone.0111430.
ieee: A. Lovrics et al., “Boolean modelling reveals new regulatory connections
between transcription factors orchestrating the development of the ventral spinal
cord,” PLoS One, vol. 9, no. 11. Public Library of Science, 2014.
ista: Lovrics A, Gao Y, Juhász B, Bock I, Byrne H, Dinnyés A, Kovács K. 2014. Boolean
modelling reveals new regulatory connections between transcription factors orchestrating
the development of the ventral spinal cord. PLoS One. 9(11), e111430.
mla: Lovrics, Anna, et al. “Boolean Modelling Reveals New Regulatory Connections
between Transcription Factors Orchestrating the Development of the Ventral Spinal
Cord.” PLoS One, vol. 9, no. 11, e111430, Public Library of Science, 2014,
doi:10.1371/journal.pone.0111430.
short: A. Lovrics, Y. Gao, B. Juhász, I. Bock, H. Byrne, A. Dinnyés, K. Kovács,
PLoS One 9 (2014).
date_created: 2018-12-11T11:55:09Z
date_published: 2014-11-14T00:00:00Z
date_updated: 2025-09-29T12:02:48Z
day: '14'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1371/journal.pone.0111430
ec_funded: 1
external_id:
isi:
- '000345558500017'
file:
- access_level: open_access
checksum: a2289b843f7463eb1233f9ce45e6a943
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:58Z
date_updated: 2020-07-14T12:45:24Z
file_id: '4850'
file_name: IST-2016-435-v1+1_journal.pone.0111430.pdf
file_size: 829363
relation: main_file
file_date_updated: 2020-07-14T12:45:24Z
fulldoi: https://doi.org/10.1371/journal.pone.0111430
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '5072'
pubrep_id: '435'
quality_controlled: '1'
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relation: research_data
status: public
scopus_import: '1'
status: public
title: Boolean modelling reveals new regulatory connections between transcription
factors orchestrating the development of the ventral spinal cord
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 9
year: '2014'
...
---
_id: '2005'
abstract:
- lang: eng
text: By eliciting a natural exploratory behavior in rats, head scanning, a study
reveals that hippocampal place cells form new, stable firing fields in those locations
where the behavior has just occurred.
article_processing_charge: No
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, Csicsvari JL. Turning heads to remember places. Nature Neuroscience.
2014;17(5):643-644. doi:10.1038/nn.3700
apa: Dupret, D., & Csicsvari, J. L. (2014). Turning heads to remember places.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3700
chicago: Dupret, David, and Jozsef L Csicsvari. “Turning Heads to Remember Places.”
Nature Neuroscience. Nature Publishing Group, 2014. https://doi.org/10.1038/nn.3700.
ieee: D. Dupret and J. L. Csicsvari, “Turning heads to remember places,” Nature
Neuroscience, vol. 17, no. 5. Nature Publishing Group, pp. 643–644, 2014.
ista: Dupret D, Csicsvari JL. 2014. Turning heads to remember places. Nature Neuroscience.
17(5), 643–644.
mla: Dupret, David, and Jozsef L. Csicsvari. “Turning Heads to Remember Places.”
Nature Neuroscience, vol. 17, no. 5, Nature Publishing Group, 2014, pp.
643–44, doi:10.1038/nn.3700.
short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 17 (2014) 643–644.
corr_author: '1'
date_created: 2018-12-11T11:55:09Z
date_published: 2014-04-25T00:00:00Z
date_updated: 2025-09-29T12:02:14Z
day: '25'
department:
- _id: JoCs
doi: 10.1038/nn.3700
external_id:
isi:
- '000335016200003'
fulldoi: https://doi.org/10.1038/nn.3700
intvolume: ' 17'
isi: 1
issue: '5'
language:
- iso: eng
month: '04'
oa_version: None
page: 643 - 644
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '5071'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Turning heads to remember places
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 17
year: '2014'
...
---
_id: '9722'
article_processing_charge: No
author:
- first_name: Anna
full_name: Lovrics, Anna
last_name: Lovrics
- first_name: Yu
full_name: Gao, Yu
last_name: Gao
- first_name: Bianka
full_name: Juhász, Bianka
last_name: Juhász
- first_name: István
full_name: Bock, István
last_name: Bock
- first_name: Helen M.
full_name: Byrne, Helen M.
last_name: Byrne
- first_name: András
full_name: Dinnyés, András
last_name: Dinnyés
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
citation:
ama: Lovrics A, Gao Y, Juhász B, et al. Transition probability between TF expression
states when Dbx2 inhibits Nkx2.2. 2014. doi:10.1371/journal.pone.0111430.s006
apa: Lovrics, A., Gao, Y., Juhász, B., Bock, I., Byrne, H. M., Dinnyés, A., &
Kovács, K. (2014). Transition probability between TF expression states when Dbx2
inhibits Nkx2.2. Public Library of Science. https://doi.org/10.1371/journal.pone.0111430.s006
chicago: Lovrics, Anna, Yu Gao, Bianka Juhász, István Bock, Helen M. Byrne, András
Dinnyés, and Krisztián Kovács. “Transition Probability between TF Expression States
When Dbx2 Inhibits Nkx2.2.” Public Library of Science, 2014. https://doi.org/10.1371/journal.pone.0111430.s006.
ieee: A. Lovrics et al., “Transition probability between TF expression states
when Dbx2 inhibits Nkx2.2.” Public Library of Science, 2014.
ista: Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács K. 2014. Transition
probability between TF expression states when Dbx2 inhibits Nkx2.2, Public Library
of Science, 10.1371/journal.pone.0111430.s006.
mla: Lovrics, Anna, et al. Transition Probability between TF Expression States
When Dbx2 Inhibits Nkx2.2. Public Library of Science, 2014, doi:10.1371/journal.pone.0111430.s006.
short: A. Lovrics, Y. Gao, B. Juhász, I. Bock, H.M. Byrne, A. Dinnyés, K. Kovács,
(2014).
date_created: 2021-07-26T14:35:00Z
date_published: 2014-11-14T00:00:00Z
date_updated: 2025-09-29T12:02:47Z
day: '14'
department:
- _id: JoCs
doi: 10.1371/journal.pone.0111430.s006
fulldoi: https://doi.org/10.1371/journal.pone.0111430.s006
month: '11'
oa_version: Published Version
publisher: Public Library of Science
related_material:
record:
- id: '2004'
relation: used_in_publication
status: public
status: public
title: Transition probability between TF expression states when Dbx2 inhibits Nkx2.2
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2014'
...
---
_id: '2251'
abstract:
- lang: eng
text: 'Sharp wave/ripple (SWR, 150–250 Hz) hippocampal events have long been postulated
to be involved in memory consolidation. However, more recent work has investigated
SWRs that occur during active waking behaviour: findings that suggest that SWRs
may also play a role in cell assembly strengthening or spatial working memory.
Do such theories of SWR function apply to animal learning? This review discusses
how general theories linking SWRs to memory-related function may explain circuit
mechanisms related to rodent spatial learning and to the associated stabilization
of new cognitive maps.'
article_number: '20120528'
article_processing_charge: No
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: David
full_name: Dupret, David
last_name: Dupret
citation:
ama: Csicsvari JL, Dupret D. Sharp wave/ripple network oscillations and learning-associated
hippocampal maps. Philosophical Transactions of the Royal Society of London
Series B, Biological Sciences. 2014;369(1635). doi:10.1098/rstb.2012.0528
apa: Csicsvari, J. L., & Dupret, D. (2014). Sharp wave/ripple network oscillations
and learning-associated hippocampal maps. Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society. https://doi.org/10.1098/rstb.2012.0528
chicago: Csicsvari, Jozsef L, and David Dupret. “Sharp Wave/Ripple Network Oscillations
and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences. Royal Society, 2014.
https://doi.org/10.1098/rstb.2012.0528.
ieee: J. L. Csicsvari and D. Dupret, “Sharp wave/ripple network oscillations and
learning-associated hippocampal maps,” Philosophical Transactions of the Royal
Society of London. Series B, Biological Sciences, vol. 369, no. 1635. Royal
Society, 2014.
ista: Csicsvari JL, Dupret D. 2014. Sharp wave/ripple network oscillations and learning-associated
hippocampal maps. Philosophical Transactions of the Royal Society of London. Series
B, Biological Sciences. 369(1635), 20120528.
mla: Csicsvari, Jozsef L., and David Dupret. “Sharp Wave/Ripple Network Oscillations
and Learning-Associated Hippocampal Maps.” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 369, no. 1635,
20120528, Royal Society, 2014, doi:10.1098/rstb.2012.0528.
short: J.L. Csicsvari, D. Dupret, Philosophical Transactions of the Royal Society
of London. Series B, Biological Sciences 369 (2014).
corr_author: '1'
das_tickbox: '1'
date_created: 2018-12-11T11:56:34Z
date_published: 2014-02-05T00:00:00Z
date_updated: 2026-08-12T06:27:15Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1098/rstb.2012.0528
external_id:
isi:
- '000332465300014'
pmid:
- '24366138'
file:
- access_level: open_access
checksum: 51beb33de71c9c19e0c205a20d206f9a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:24Z
date_updated: 2020-07-14T12:45:34Z
file_id: '5006'
file_name: IST-2016-527-v1+1_20120528.full.pdf
file_size: 771896
relation: main_file
file_date_updated: 2020-07-14T12:45:34Z
fulldoi: https://doi.org/10.1098/rstb.2012.0528
has_accepted_license: '1'
intvolume: ' 369'
isi: 1
issue: '1635'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society
publist_id: '4697'
pubrep_id: '527'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sharp wave/ripple network oscillations and learning-associated hippocampal
maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
short: CC BY (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 369
year: '2014'
...
---
_id: '2276'
abstract:
- lang: eng
text: The problem of minimizing the Potts energy function frequently occurs in computer
vision applications. One way to tackle this NP-hard problem was proposed by Kovtun
[19, 20]. It identifies a part of an optimal solution by running k maxflow computations,
where k is the number of labels. The number of “labeled” pixels can be significant
in some applications, e.g. 50-93% in our tests for stereo. We show how to reduce
the runtime to O (log k) maxflow computations (or one parametric maxflow computation).
Furthermore, the output of our algorithm allows to speed-up the subsequent alpha
expansion for the unlabeled part, or can be used as it is for time-critical applications.
To derive our technique, we generalize the algorithm of Felzenszwalb et al. [7]
for Tree Metrics . We also show a connection to k-submodular functions from combinatorial
optimization, and discuss k-submodular relaxations for general energy functions.
article_processing_charge: No
arxiv: 1
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
citation:
ama: 'Gridchyn I, Kolmogorov V. Potts model, parametric maxflow and k-submodular
functions. In: IEEE; 2013:2320-2327. doi:10.1109/ICCV.2013.288'
apa: 'Gridchyn, I., & Kolmogorov, V. (2013). Potts model, parametric maxflow
and k-submodular functions (pp. 2320–2327). Presented at the ICCV: International
Conference on Computer Vision, Sydney, Australia: IEEE. https://doi.org/10.1109/ICCV.2013.288'
chicago: Gridchyn, Igor, and Vladimir Kolmogorov. “Potts Model, Parametric Maxflow
and k-Submodular Functions,” 2320–27. IEEE, 2013. https://doi.org/10.1109/ICCV.2013.288.
ieee: 'I. Gridchyn and V. Kolmogorov, “Potts model, parametric maxflow and k-submodular
functions,” presented at the ICCV: International Conference on Computer Vision,
Sydney, Australia, 2013, pp. 2320–2327.'
ista: 'Gridchyn I, Kolmogorov V. 2013. Potts model, parametric maxflow and k-submodular
functions. ICCV: International Conference on Computer Vision, 2320–2327.'
mla: Gridchyn, Igor, and Vladimir Kolmogorov. Potts Model, Parametric Maxflow
and k-Submodular Functions. IEEE, 2013, pp. 2320–27, doi:10.1109/ICCV.2013.288.
short: I. Gridchyn, V. Kolmogorov, in:, IEEE, 2013, pp. 2320–2327.
conference:
end_date: 2013-12-08
location: Sydney, Australia
name: 'ICCV: International Conference on Computer Vision'
start_date: 2013-12-01
corr_author: '1'
date_created: 2018-12-11T11:56:43Z
date_published: 2013-12-01T00:00:00Z
date_updated: 2025-09-29T14:27:49Z
day: '01'
department:
- _id: JoCs
- _id: VlKo
doi: 10.1109/ICCV.2013.288
external_id:
arxiv:
- '1310.1771'
isi:
- '000351830500290'
fulldoi: https://doi.org/10.1109/ICCV.2013.288
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1310.1771
month: '12'
oa: 1
oa_version: Preprint
page: 2320 - 2327
publication_status: published
publisher: IEEE
publist_id: '4668'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Potts model, parametric maxflow and k-submodular functions
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2013'
...
---
_id: '2840'
abstract:
- lang: eng
text: It is known that the entorhinal cortex plays a crucial role in spatial cognition
in rodents. Neuroanatomical and electrophysiological data suggest that there is
a functional distinction between 2 subregions within the entorhinal cortex, the
medial entorhinal cortex (MEC), and the lateral entorhinal cortex (LEC). Rats
with MEC or LEC lesions were trained in 2 navigation tasks requiring allothetic
(water maze task) or idiothetic (path integration) information processing and
2-object exploration tasks allowing testing of spatial and nonspatial processing
of intramaze objects. MEC lesions mildly affected place navigation in the water
maze and produced a path integration deficit. They also altered the processing
of spatial information in both exploration tasks while sparing the processing
of nonspatial information. LEC lesions did not affect navigation abilities in
both the water maze and the path integration tasks. They altered spatial and nonspatial
processing in the object exploration task but not in the one-trial recognition
task. Overall, these results indicate that the MEC is important for spatial processing
and path integration. The LEC has some influence on both spatial and nonspatial
processes, suggesting that the 2 kinds of information interact at the level of
the EC.
article_processing_charge: No
author:
- first_name: Tiffany
full_name: Van Cauter, Tiffany
last_name: Van Cauter
- first_name: Jeremy
full_name: Camon, Jeremy
last_name: Camon
- first_name: Alice
full_name: Alvernhe, Alice
id: 467FB3D4-F248-11E8-B48F-1D18A9856A87
last_name: Alvernhe
- first_name: Coralie
full_name: Elduayen, Coralie
last_name: Elduayen
- first_name: Francesca
full_name: Sargolini, Francesca
last_name: Sargolini
- first_name: Étienne
full_name: Save, Étienne
last_name: Save
citation:
ama: Van Cauter T, Camon J, Alvernhe A, Elduayen C, Sargolini F, Save É. Distinct
roles of medial and lateral entorhinal cortex in spatial cognition. Cerebral
Cortex. 2013;23(2):451-459. doi:10.1093/cercor/bhs033
apa: Van Cauter, T., Camon, J., Alvernhe, A., Elduayen, C., Sargolini, F., &
Save, É. (2013). Distinct roles of medial and lateral entorhinal cortex in spatial
cognition. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/bhs033
chicago: Van Cauter, Tiffany, Jeremy Camon, Alice Alvernhe, Coralie Elduayen, Francesca
Sargolini, and Étienne Save. “Distinct Roles of Medial and Lateral Entorhinal
Cortex in Spatial Cognition.” Cerebral Cortex. Oxford University Press,
2013. https://doi.org/10.1093/cercor/bhs033.
ieee: T. Van Cauter, J. Camon, A. Alvernhe, C. Elduayen, F. Sargolini, and É. Save,
“Distinct roles of medial and lateral entorhinal cortex in spatial cognition,”
Cerebral Cortex, vol. 23, no. 2. Oxford University Press, pp. 451–459,
2013.
ista: Van Cauter T, Camon J, Alvernhe A, Elduayen C, Sargolini F, Save É. 2013.
Distinct roles of medial and lateral entorhinal cortex in spatial cognition. Cerebral
Cortex. 23(2), 451–459.
mla: Van Cauter, Tiffany, et al. “Distinct Roles of Medial and Lateral Entorhinal
Cortex in Spatial Cognition.” Cerebral Cortex, vol. 23, no. 2, Oxford University
Press, 2013, pp. 451–59, doi:10.1093/cercor/bhs033.
short: T. Van Cauter, J. Camon, A. Alvernhe, C. Elduayen, F. Sargolini, É. Save,
Cerebral Cortex 23 (2013) 451–459.
date_created: 2018-12-11T11:59:52Z
date_published: 2013-02-01T00:00:00Z
date_updated: 2025-09-29T13:45:23Z
day: '01'
department:
- _id: JoCs
doi: 10.1093/cercor/bhs033
external_id:
isi:
- '000313529600020'
fulldoi: https://doi.org/10.1093/cercor/bhs033
intvolume: ' 23'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 451 - 459
publication: Cerebral Cortex
publication_status: published
publisher: Oxford University Press
publist_id: '3958'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct roles of medial and lateral entorhinal cortex in spatial cognition
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 23
year: '2013'
...
---
_id: '2845'
abstract:
- lang: eng
text: At synapses formed between dissociated neurons, about half of all synaptic
vesicles are refractory to evoked release, forming the so-called "resting
pool." Here, we use optical measurements of vesicular pH to study developmental
changes in pool partitioning and vesicle cycling in cultured hippocampal slices.
Two-photon imaging of a genetically encoded two-color release sensor (ratio-sypHy)
allowed us to perform calibrated measurements at individual Schaffer collateral
boutons. Mature boutons released a large fraction of their vesicles during simulated
place field activity, and vesicle retrieval rates were 7-fold higher compared
to immature boutons. Saturating stimulation mobilized essentially all vesicles
at mature synapses. Resting pool formation and a concomitant reduction in evoked
release was induced by chronic depolarization but not by acute inhibition of the
protein phosphatase calcineurin. We conclude that synapses in CA1 undergo a prominent
refinement of vesicle use during early postnatal development that is not recapitulated
in dissociated neuronal culture.
article_processing_charge: No
author:
- first_name: Tobias
full_name: Rose, Tobias
last_name: Rose
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Karel
full_name: Jezek, Karel
last_name: Jezek
- first_name: Thomas
full_name: Oertner, Thomas
last_name: Oertner
citation:
ama: Rose T, Schönenberger P, Jezek K, Oertner T. Developmental refinement of vesicle
cycling at Schaffer collateral synapses. Neuron. 2013;77(6):1109-1121.
doi:10.1016/j.neuron.2013.01.021
apa: Rose, T., Schönenberger, P., Jezek, K., & Oertner, T. (2013). Developmental
refinement of vesicle cycling at Schaffer collateral synapses. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2013.01.021
chicago: Rose, Tobias, Philipp Schönenberger, Karel Jezek, and Thomas Oertner. “Developmental
Refinement of Vesicle Cycling at Schaffer Collateral Synapses.” Neuron.
Elsevier, 2013. https://doi.org/10.1016/j.neuron.2013.01.021.
ieee: T. Rose, P. Schönenberger, K. Jezek, and T. Oertner, “Developmental refinement
of vesicle cycling at Schaffer collateral synapses,” Neuron, vol. 77, no.
6. Elsevier, pp. 1109–1121, 2013.
ista: Rose T, Schönenberger P, Jezek K, Oertner T. 2013. Developmental refinement
of vesicle cycling at Schaffer collateral synapses. Neuron. 77(6), 1109–1121.
mla: Rose, Tobias, et al. “Developmental Refinement of Vesicle Cycling at Schaffer
Collateral Synapses.” Neuron, vol. 77, no. 6, Elsevier, 2013, pp. 1109–21,
doi:10.1016/j.neuron.2013.01.021.
short: T. Rose, P. Schönenberger, K. Jezek, T. Oertner, Neuron 77 (2013) 1109–1121.
date_created: 2018-12-11T11:59:54Z
date_published: 2013-03-20T00:00:00Z
date_updated: 2025-09-29T13:42:59Z
day: '20'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2013.01.021
external_id:
isi:
- '000316645000012'
fulldoi: https://doi.org/10.1016/j.neuron.2013.01.021
intvolume: ' 77'
isi: 1
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 1109 - 1121
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '3949'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental refinement of vesicle cycling at Schaffer collateral synapses
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 77
year: '2013'
...
---
_id: '2860'
abstract:
- lang: eng
text: 'In the hippocampus, cell assemblies forming mnemonic representations of space
are thought to arise as a result of changes in functional connections of pyramidal
cells. We have found that CA1 interneuron circuits are also reconfigured during
goal-oriented spatial learning through modification of inputs from pyramidal cells.
As learning progressed, new pyramidal assemblies expressed in theta cycles alternated
with previously established ones, and eventually overtook them. The firing patterns
of interneurons developed a relationship to new, learning-related assemblies:
some interneurons associated their activity with new pyramidal assemblies while
some others dissociated from them. These firing associations were explained by
changes in the weight of monosynaptic inputs received by interneurons from new
pyramidal assemblies, as these predicted the associational changes. Spatial learning
thus engages circuit modifications in the hippocampus that incorporate a redistribution
of inhibitory activity that might assist in the segregation of competing pyramidal
cell assembly patterns in space and time.'
acknowledgement: D.D. and J.C. were supported by a MRC Intramural Programme Grant
U138197111
article_processing_charge: No
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, O’Neill J, Csicsvari JL. Dynamic reconfiguration of hippocampal interneuron
circuits during spatial learning. Neuron. 2013;78(1):166-180. doi:10.1016/j.neuron.2013.01.033
apa: Dupret, D., O’Neill, J., & Csicsvari, J. L. (2013). Dynamic reconfiguration
of hippocampal interneuron circuits during spatial learning. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2013.01.033
chicago: Dupret, David, Joseph O’Neill, and Jozsef L Csicsvari. “Dynamic Reconfiguration
of Hippocampal Interneuron Circuits during Spatial Learning.” Neuron. Elsevier,
2013. https://doi.org/10.1016/j.neuron.2013.01.033.
ieee: D. Dupret, J. O’Neill, and J. L. Csicsvari, “Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning,” Neuron, vol. 78, no. 1.
Elsevier, pp. 166–180, 2013.
ista: Dupret D, O’Neill J, Csicsvari JL. 2013. Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning. Neuron. 78(1), 166–180.
mla: Dupret, David, et al. “Dynamic Reconfiguration of Hippocampal Interneuron Circuits
during Spatial Learning.” Neuron, vol. 78, no. 1, Elsevier, 2013, pp. 166–80,
doi:10.1016/j.neuron.2013.01.033.
short: D. Dupret, J. O’Neill, J.L. Csicsvari, Neuron 78 (2013) 166–180.
corr_author: '1'
date_created: 2018-12-11T11:59:59Z
date_published: 2013-03-21T00:00:00Z
date_updated: 2025-09-29T13:37:37Z
day: '21'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2013.01.033
ec_funded: 1
external_id:
isi:
- '000317556000015'
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checksum: 0e18cb8561153ddb50bb5af16e7c9e97
content_type: application/pdf
creator: dernst
date_created: 2019-01-23T08:08:07Z
date_updated: 2020-07-14T12:45:52Z
file_id: '5877'
file_name: 2013_Neuron_Dupret.pdf
file_size: 2637837
relation: main_file
file_date_updated: 2020-07-14T12:45:52Z
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has_accepted_license: '1'
intvolume: ' 78'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 166 - 180
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '3929'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic reconfiguration of hippocampal interneuron circuits during spatial
learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 78
year: '2013'
...
---
_id: '476'
abstract:
- lang: eng
text: 'Maternal exposure to infection occurring mid-gestation produces a three-fold
increase in the risk of schizophrenia in the offspring. The critical initiating
factor appears to be the maternal immune activation (MIA) that follows infection.
This process can be induced in rodents by exposure of pregnant dams to the viral
mimic Poly I:C, which triggers an immune response that results in structural,
functional, behavioral, and electrophysiological phenotypes in the adult offspring
that model those seen in schizophrenia. We used this model to explore the role
of synchronization in brain neural networks, a process thought to be dysfunctional
in schizophrenia and previously associated with positive, negative, and cognitive
symptoms of schizophrenia. Exposure of pregnant dams to Poly I:C on GD15 produced
an impairment in long-range neural synchrony in adult offspring between two regions
implicated in schizophrenia pathology; the hippocampus and the medial prefrontal
cortex (mPFC). This reduction in synchrony was ameliorated by acute doses of the
antipsychotic clozapine. MIA animals have previously been shown to have impaired
pre-pulse inhibition (PPI), a gold-standard measure of schizophrenia-like deficits
in animal models. Our data showed that deficits in synchrony were positively correlated
with the impairments in PPI. Subsequent analysis of LFP activity during the PPI
response also showed that reduced coupling between the mPFC and the hippocampus
following processing of the pre-pulse was associated with reduced PPI. The ability
of the MIA intervention to model neurodevelopmental aspects of schizophrenia pathology
provides a useful platform from which to investigate the ontogeny of aberrant
synchronous processes. Further, the way in which the model expresses translatable
deficits such as aberrant synchrony and reduced PPI will allow researchers to
explore novel intervention strategies targeted to these changes. '
article_processing_charge: No
author:
- first_name: Desiree
full_name: Dickerson, Desiree
id: 444EB89E-F248-11E8-B48F-1D18A9856A87
last_name: Dickerson
- first_name: David
full_name: Bilkey, David
last_name: Bilkey
citation:
ama: 'Dickerson D, Bilkey D. Aberrant neural synchrony in the maternal immune activation
model: Using translatable measures to explore targeted interventions. Frontiers
in Behavioral Neuroscience. 2013;7(DEC). doi:10.3389/fnbeh.2013.00217'
apa: 'Dickerson, D., & Bilkey, D. (2013). Aberrant neural synchrony in the maternal
immune activation model: Using translatable measures to explore targeted interventions.
Frontiers in Behavioral Neuroscience. Frontiers Research Foundation. https://doi.org/10.3389/fnbeh.2013.00217'
chicago: 'Dickerson, Desiree, and David Bilkey. “Aberrant Neural Synchrony in the
Maternal Immune Activation Model: Using Translatable Measures to Explore Targeted
Interventions.” Frontiers in Behavioral Neuroscience. Frontiers Research
Foundation, 2013. https://doi.org/10.3389/fnbeh.2013.00217.'
ieee: 'D. Dickerson and D. Bilkey, “Aberrant neural synchrony in the maternal immune
activation model: Using translatable measures to explore targeted interventions,”
Frontiers in Behavioral Neuroscience, vol. 7, no. DEC. Frontiers Research
Foundation, 2013.'
ista: 'Dickerson D, Bilkey D. 2013. Aberrant neural synchrony in the maternal immune
activation model: Using translatable measures to explore targeted interventions.
Frontiers in Behavioral Neuroscience. 7(DEC).'
mla: 'Dickerson, Desiree, and David Bilkey. “Aberrant Neural Synchrony in the Maternal
Immune Activation Model: Using Translatable Measures to Explore Targeted Interventions.”
Frontiers in Behavioral Neuroscience, vol. 7, no. DEC, Frontiers Research
Foundation, 2013, doi:10.3389/fnbeh.2013.00217.'
short: D. Dickerson, D. Bilkey, Frontiers in Behavioral Neuroscience 7 (2013).
date_created: 2018-12-11T11:46:41Z
date_published: 2013-12-27T00:00:00Z
date_updated: 2025-09-30T07:30:04Z
day: '27'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.3389/fnbeh.2013.00217
external_id:
isi:
- '000329175600001'
file:
- access_level: open_access
checksum: cd7183121e56251176100ccac165c95c
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:10Z
date_updated: 2020-07-14T12:46:35Z
file_id: '5128'
file_name: IST-2018-953-v1+1_2013_Dickerson_Aberrant_neural.pdf
file_size: 530134
relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
fulldoi: https://doi.org/10.3389/fnbeh.2013.00217
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
issue: DEC
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Frontiers in Behavioral Neuroscience
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '7346'
pubrep_id: '953'
quality_controlled: '1'
status: public
title: 'Aberrant neural synchrony in the maternal immune activation model: Using translatable
measures to explore targeted interventions'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 7
year: '2013'
...
---
_id: '2949'
article_processing_charge: No
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, Csicsvari JL. The medial entorhinal cortex keeps Up. Nature Neuroscience.
2012;15(11):1471-1472. doi:10.1038/nn.3245
apa: Dupret, D., & Csicsvari, J. L. (2012). The medial entorhinal cortex keeps
Up. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3245
chicago: Dupret, David, and Jozsef L Csicsvari. “The Medial Entorhinal Cortex Keeps
Up.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3245.
ieee: D. Dupret and J. L. Csicsvari, “The medial entorhinal cortex keeps Up,” Nature
Neuroscience, vol. 15, no. 11. Nature Publishing Group, pp. 1471–1472, 2012.
ista: Dupret D, Csicsvari JL. 2012. The medial entorhinal cortex keeps Up. Nature
Neuroscience. 15(11), 1471–1472.
mla: Dupret, David, and Jozsef L. Csicsvari. “The Medial Entorhinal Cortex Keeps
Up.” Nature Neuroscience, vol. 15, no. 11, Nature Publishing Group, 2012,
pp. 1471–72, doi:10.1038/nn.3245.
short: D. Dupret, J.L. Csicsvari, Nature Neuroscience 15 (2012) 1471–1472.
corr_author: '1'
date_created: 2018-12-11T12:00:30Z
date_published: 2012-11-01T00:00:00Z
date_updated: 2025-09-30T08:11:33Z
day: '01'
department:
- _id: JoCs
doi: 10.1038/nn.3245
external_id:
isi:
- '000310424900003'
fulldoi: https://doi.org/10.1038/nn.3245
intvolume: ' 15'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- url: http://www.mrcbndu.ox.ac.uk/publications/medial-entorhinal-cortex-keeps
month: '11'
oa_version: None
page: 1471 - 1472
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3782'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The medial entorhinal cortex keeps Up
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2012'
...
---
_id: '2958'
abstract:
- lang: eng
text: 'The activity of hippocampal pyramidal cells reflects both the current position
of the animal and information related to its current behavior. Here we investigated
whether single hippocampal neurons can encode several independent features defining
trials during a memory task. We also tested whether task-related information is
represented by partial remapping of the place cell population or, instead, via
firing rate modulation of spatially stable place cells. To address these two questions,
the activity of hippocampal neurons was recorded in rats performing a conditional
discrimination task on a modified T-maze in which the identity of a food reward
guided behavior. When the rat was on the central arm of the maze, the firing rate
of pyramidal cells changed depending on two independent factors: (1) the identity
of the food reward given to the animal and (2) the previous location of the animal
on the maze. Importantly, some pyramidal cells encoded information relative to
both factors. This trial-type specific and retrospective coding did not interfere
with the spatial representation of the maze: hippocampal cells had stable place
fields and their theta-phase precession profiles were unaltered during the task,
indicating that trial-related information was encoded via rate remapping. During
error trials, encoding of both trial-related information and spatial location
was impaired. Finally, we found that pyramidal cells also encode trial-related
information via rate remapping during the continuous version of the rewarded alternation
task without delays. These results suggest that hippocampal neurons can encode
several task-related cognitive aspects via rate remapping.'
acknowledgement: J.C. was supported by a MRC Intramural Programme Grant (U138197111)
and a European Research Council Starter Grant (281511). K.A. held a Wellcome Trust
PhD studentship and a Humboldt Research Fellowship for Postdoctoral Researchers.
D.M.B. was supported by Wellcome Trust Senior Fellowships (074385 and 087736).
article_processing_charge: No
author:
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: J Nick
full_name: Rawlins, J Nick
last_name: Rawlins
- first_name: David
full_name: Bannerman, David
last_name: Bannerman
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. Hippocampal place cells can
encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 2012;32(42):14752-14766. doi:10.1523/JNEUROSCI.6175-11.2012
apa: Allen, K., Rawlins, J. N., Bannerman, D., & Csicsvari, J. L. (2012). Hippocampal
place cells can encode multiple trial-dependent features through rate remapping.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6175-11.2012
chicago: Allen, Kevin, J Nick Rawlins, David Bannerman, and Jozsef L Csicsvari.
“Hippocampal Place Cells Can Encode Multiple Trial-Dependent Features through
Rate Remapping.” Journal of Neuroscience. Society for Neuroscience, 2012.
https://doi.org/10.1523/JNEUROSCI.6175-11.2012.
ieee: K. Allen, J. N. Rawlins, D. Bannerman, and J. L. Csicsvari, “Hippocampal place
cells can encode multiple trial-dependent features through rate remapping,” Journal
of Neuroscience, vol. 32, no. 42. Society for Neuroscience, pp. 14752–14766,
2012.
ista: Allen K, Rawlins JN, Bannerman D, Csicsvari JL. 2012. Hippocampal place cells
can encode multiple trial-dependent features through rate remapping. Journal of
Neuroscience. 32(42), 14752–14766.
mla: Allen, Kevin, et al. “Hippocampal Place Cells Can Encode Multiple Trial-Dependent
Features through Rate Remapping.” Journal of Neuroscience, vol. 32, no.
42, Society for Neuroscience, 2012, pp. 14752–66, doi:10.1523/JNEUROSCI.6175-11.2012.
short: K. Allen, J.N. Rawlins, D. Bannerman, J.L. Csicsvari, Journal of Neuroscience
32 (2012) 14752–14766.
date_created: 2018-12-11T12:00:33Z
date_published: 2012-10-17T00:00:00Z
date_updated: 2025-09-30T08:07:06Z
day: '17'
department:
- _id: JoCs
doi: 10.1523/JNEUROSCI.6175-11.2012
ec_funded: 1
external_id:
isi:
- '000310054000028'
pmid:
- '23077060'
fulldoi: https://doi.org/10.1523/JNEUROSCI.6175-11.2012
intvolume: ' 32'
isi: 1
issue: '42'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531717/
month: '10'
oa: 1
oa_version: Submitted Version
page: 14752 - 14766
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '3768'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hippocampal place cells can encode multiple trial-dependent features through
rate remapping
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 32
year: '2012'
...