[{"article_processing_charge":"No","OA_place":"publisher","degree_awarded":"MS","day":"14","ddc":["570"],"author":[{"full_name":"Vladimirtsev, Dmitrii","first_name":"Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","last_name":"Vladimirtsev"}],"supervisor":[{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","first_name":"Jiří"}],"title":"Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide gated channels","page":"22","publication_status":"published","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"file":[{"relation":"main_file","file_id":"21033","embargo":"2027-01-01","file_name":"2026_Vladimirtsev_Dmitrii_Thesis.pdf","embargo_to":"open_access","checksum":"812857b2fbe3f6113bef22fd04bccd3e","date_created":"2026-01-21T14:12:13Z","date_updated":"2026-01-21T14:12:13Z","file_size":2867531,"creator":"dvladimi","access_level":"closed","content_type":"application/pdf"},{"file_name":"Source Files.zip","relation":"source_file","file_id":"21034","checksum":"2b969f97f8d7461bea3d255f48c2219c","creator":"dvladimi","date_updated":"2026-01-28T12:38:19Z","file_size":25023066,"date_created":"2026-01-21T14:41:58Z","access_level":"closed","content_type":"application/x-zip-compressed"}],"publication_identifier":{"issn":["2791-4585"]},"language":[{"iso":"eng"}],"year":"2026","type":"dissertation","has_accepted_license":"1","related_material":{"record":[{"relation":"part_of_dissertation","id":"20982","status":"public"}]},"project":[{"grant_number":"101142681","name":"Cyclic nucleotides as second messengers in plants","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"}],"date_created":"2026-01-09T09:22:48Z","date_updated":"2026-04-07T11:41:44Z","month":"01","_id":"20964","oa_version":"Published Version","doi":"10.15479/AT-ISTA-20964","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"file_date_updated":"2026-01-28T12:38:19Z","publisher":"Institute of Science and Technology Austria","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"mla":"Vladimirtsev, Dmitrii. Armadillo Repeat Only Proteins Are Master Regulators of Plant Cyclic-Nucleotide Gated Channels. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-20964.","short":"D. Vladimirtsev, Armadillo Repeat Only Proteins Are Master Regulators of Plant Cyclic-Nucleotide Gated Channels, Institute of Science and Technology Austria, 2026.","chicago":"Vladimirtsev, Dmitrii. “Armadillo Repeat Only Proteins Are Master Regulators of Plant Cyclic-Nucleotide Gated Channels.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-20964.","ista":"Vladimirtsev D. 2026. Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide gated channels. Institute of Science and Technology Austria.","apa":"Vladimirtsev, D. (2026). Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide gated channels. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-20964","ieee":"D. Vladimirtsev, “Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide gated channels,” Institute of Science and Technology Austria, 2026.","ama":"Vladimirtsev D. Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide gated channels. 2026. doi:10.15479/AT-ISTA-20964"},"date_published":"2026-01-14T00:00:00Z","alternative_title":["ISTA Master’s Thesis"],"corr_author":"1","status":"public"},{"publisher":"Springer Nature","file_date_updated":"2026-01-21T08:21:11Z","department":[{"_id":"EdHa"},{"_id":"CaHe"}],"corr_author":"1","status":"public","ec_funded":1,"intvolume":" 22","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_published":"2026-01-05T00:00:00Z","citation":{"ama":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. 2026;22:139-150. doi:10.1038/s41567-025-03122-1","ieee":"N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo,” Nature Physics, vol. 22. Springer Nature, pp. 139–150, 2026.","apa":"Mishra, N., Li, Y. I., Hannezo, E. B., & Heisenberg, C.-P. J. (2026). Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03122-1","ista":"Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo. Nature Physics. 22, 139–150.","short":"N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026) 139–150.","chicago":"Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03122-1.","mla":"Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics, vol. 22, Springer Nature, 2026, pp. 139–50, doi:10.1038/s41567-025-03122-1."},"related_material":{"link":[{"url":"https://ista.ac.at/en/news/geometry-shapes-life/","relation":"research_data","description":"News on ISTA website"}]},"type":"journal_article","PlanS_conform":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","doi":"10.1038/s41567-025-03122-1","scopus_import":"1","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020","grant_number":"101034413"},{"name":"Cytoplasmic self-organization into cell-like compartments as a common guiding principle in early animal development","_id":"917c023a-16d5-11f0-9cad-eb5cafc52090"}],"_id":"21015","oa_version":"Published Version","month":"01","volume":22,"quality_controlled":"1","date_updated":"2026-04-28T12:55:30Z","date_created":"2026-01-20T10:12:19Z","file":[{"success":1,"creator":"dernst","date_created":"2026-01-21T08:21:11Z","file_size":7335694,"date_updated":"2026-01-21T08:21:11Z","content_type":"application/pdf","access_level":"open_access","file_name":"2026_NaturePhysics_Mishra.pdf","file_id":"21026","relation":"main_file","checksum":"0ab7ac2fbcb61a364dba57152db64ed7"}],"acknowledged_ssus":[{"_id":"PreCl"},{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["1745-2473"],"issnl":[" 1745-2473"],"eissn":["1745-2481"]},"publication":"Nature Physics","year":"2026","article_type":"original","external_id":{"oaworkid":["W7118187193"]},"language":[{"iso":"eng"}],"oaworkid":1,"author":[{"orcid":"0000-0002-6425-5788","last_name":"Mishra","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","full_name":"Mishra, Nikhil","first_name":"Nikhil"},{"full_name":"Li, Yuting I","first_name":"Yuting I","last_name":"Li","id":"ee7a5ca8-8b71-11ed-b662-b3341c05b7eb"},{"full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561"},{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J"}],"ddc":["570"],"day":"05","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","OA_place":"publisher","oa":1,"acknowledgement":"We thank N. Petridou (EMBL) for sharing results before publication. N.M. was supported by funding from the European Union’s Horizon 2020 programme under the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411. Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413. The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project ID 1.844. We would like to thank past and present members of the Heisenberg and Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic, N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria through resources provided by the Aquatics Facility, Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab Support Facility (LSF). Open access funding provided by Institute of Science and Technology (IST Austria).","publication_status":"published","page":"139-150","title":"Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo","abstract":[{"lang":"eng","text":"Early embryo geometry is one of the most invariant species-specific traits, yet its role in ensuring developmental reproducibility and robustness remains underexplored. Here we show that in zebrafish, the geometry of the fertilized egg—specifically its curvature and volume—serves as a critical initial condition triggering a cascade of events that influence development. The embryo geometry guides patterned asymmetric cell divisions in the blastoderm, generating radial gradients of cell volume and nucleocytoplasmic ratio. These gradients generate mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell cycle periods independently of other cells. We demonstrate that reducing cell autonomy reshapes these waves, emphasizing the instructive role of geometry-derived volume patterns in setting the intrinsic period of the cell cycle oscillator. In addition to organizing cell cycles, early embryo geometry spatially patterns zygotic genome activation at the midblastula transition, a key step in establishing embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation pattern and causes ectopic germ layer specification, underscoring the developmental significance of geometry. Together, our findings reveal a symmetry-breaking function of early embryo geometry in coordinating cell cycle and transcriptional patterning."}]},{"file":[{"checksum":"81272c19df41c696c1737168d3ea8c16","file_name":"2026_AppliedEnergyMaterials_Busato.pdf","file_id":"21222","relation":"main_file","content_type":"application/pdf","access_level":"open_access","success":1,"creator":"dernst","date_updated":"2026-02-12T13:55:28Z","file_size":5977526,"date_created":"2026-02-12T13:55:28Z"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"LifeSc"}],"publication_identifier":{"eissn":["2574-0962"]},"publication":"ACS Applied Energy Materials","year":"2026","article_type":"original","language":[{"iso":"eng"}],"author":[{"full_name":"Busato, Matteo","first_name":"Matteo","last_name":"Busato"},{"full_name":"Tuccillo, Mariarosaria","first_name":"Mariarosaria","last_name":"Tuccillo"},{"last_name":"Celeste","first_name":"Arcangelo","full_name":"Celeste, Arcangelo"},{"last_name":"Tofoni","first_name":"Alessandro","full_name":"Tofoni, Alessandro"},{"last_name":"Silvestri","first_name":"Laura","full_name":"Silvestri, Laura"},{"last_name":"D’Angelo","first_name":"Paola","full_name":"D’Angelo, Paola"},{"first_name":"Stefan Alexander","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","orcid":"0000-0003-2902-5319"},{"full_name":"Brutti, Sergio","first_name":"Sergio","last_name":"Brutti"}],"ddc":["540"],"day":"12","issue":"1","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","OA_place":"publisher","oa":1,"acknowledgement":"Elettra-Sincrotrone Trieste S.C.p.A. and its staff are acknowledged for providing synchrotron radiation beamtime and laboratory facilities, in particular the MCX and XAFS beamlines, where the XRD and XAS experiments have been carried out, supported by the projects number: 20217082, 20205109, and 20195014. This study was carried out within the MOST─Sustainable Mobility Center and received funding from the European Union Next-Generation EU (PIANO NAZIONALE DI RIPRESA E RESILIENZA (PNRR)─MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.4─D.D. 1033 17/06/2022, CN00000023). Moreover, the contribution of S.B. and A.C. to this study was carried out within the NEST─Network for Energy Sustainable Transition and received funding from the European Union Next-Generation EU (PNRR─MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.3─D.D. 1561 11/10/2022, B53C22004070006). This manuscript reflects only the authors’ views and opinions, neither the European Union nor the European Commission can be considered responsible for them. Two of us, S.B. and S.A.F., would like to thank the Alistore ERI. L.S. received funds from the Ministry of Ecological Transition in the “Ricerca di Sistema Elettrico” framework. S.A.F. is indebted to ISTA for support. The Scientific Service Units of ISTA supported this research through resources provided by the Lab Support Facility and the Miba Machine Shop.","publication_status":"published","page":"686-697","title":"Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation","abstract":[{"lang":"eng","text":"Formation during the first cycles of Li-rich layered oxide (LRLO) cathode materials consolidates the interphase and leads to structural changes that are decisive for long-term cyclability. However, the nature and effect of the changes are material-dependent and unknown for the important class of Co-free, Ni-poor LRLOs. Here, we analyze the processes during the tailored formation procedure of a typical class member, Li1.28Ni0.15Mn0.57O2, and demonstrate that it remarkably changes lattice composition and structure as a prerequisite for stable cycling. We combine electrochemistry, operando mass spectrometry, X-ray diffraction, and X-ray absorption spectroscopy with density functional theory simulations. Activation most prominently compresses the layer spacing along the c-axis and increases reversible structural breathing. The large capacity of ∼250 mAh g–1 originates from the Ni2+/Ni4+ and O2–/O– redox couples. Electron exchange during O-redox is smeared over the entire anionic sublattice rather than localized on specific oxygen atomic sites. This redox mechanism is reversible without detrimental oxygen evolution, avoiding continued degradation common in conventional LRLOs. Sequential Ni- and O-redox during activation irreversibly distorts the coordination of the redox-inactive Mn4+ centers. This structural evolution of the MnO6 octahedra appears to enable the superior electrochemical performance of this LRLO phase. These findings define an activation pathway for the important class of Co-free, Ni-poor LRLOs, offering potential guidance for the rational design of high-performance, more sustainable cathode materials."}],"publisher":"American Chemical Society","file_date_updated":"2026-02-12T13:55:28Z","department":[{"_id":"StFr"}],"status":"public","corr_author":"1","intvolume":" 9","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-01-12T00:00:00Z","citation":{"mla":"Busato, Matteo, et al. “Structural Rearrangements of a Cobalt-Free Lithium-Rich Layered Oxide Cathode during Formation.” ACS Applied Energy Materials, vol. 9, no. 1, American Chemical Society, 2026, pp. 686–97, doi:10.1021/acsaem.5c03511.","chicago":"Busato, Matteo, Mariarosaria Tuccillo, Arcangelo Celeste, Alessandro Tofoni, Laura Silvestri, Paola D’Angelo, Stefan Alexander Freunberger, and Sergio Brutti. “Structural Rearrangements of a Cobalt-Free Lithium-Rich Layered Oxide Cathode during Formation.” ACS Applied Energy Materials. American Chemical Society, 2026. https://doi.org/10.1021/acsaem.5c03511.","short":"M. Busato, M. Tuccillo, A. Celeste, A. Tofoni, L. Silvestri, P. D’Angelo, S.A. Freunberger, S. Brutti, ACS Applied Energy Materials 9 (2026) 686–697.","ista":"Busato M, Tuccillo M, Celeste A, Tofoni A, Silvestri L, D’Angelo P, Freunberger SA, Brutti S. 2026. Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation. ACS Applied Energy Materials. 9(1), 686–697.","apa":"Busato, M., Tuccillo, M., Celeste, A., Tofoni, A., Silvestri, L., D’Angelo, P., … Brutti, S. (2026). Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation. ACS Applied Energy Materials. American Chemical Society. https://doi.org/10.1021/acsaem.5c03511","ieee":"M. Busato et al., “Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation,” ACS Applied Energy Materials, vol. 9, no. 1. American Chemical Society, pp. 686–697, 2026.","ama":"Busato M, Tuccillo M, Celeste A, et al. Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode during formation. ACS Applied Energy Materials. 2026;9(1):686-697. doi:10.1021/acsaem.5c03511"},"type":"journal_article","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","has_accepted_license":"1","doi":"10.1021/acsaem.5c03511","scopus_import":"1","_id":"21040","oa_version":"Published Version","month":"01","date_created":"2026-01-25T23:01:40Z","quality_controlled":"1","volume":9,"date_updated":"2026-02-12T14:04:04Z"},{"year":"2026","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"file":[{"creator":"snaik","title":"Cell git repository","description":"Python3 library written in C++20 to integrate vertex models. Please read the readme at https://github.com/yketa/cells/blob/main/README.md for detailed instructions for installation and usage of the code in this repository. 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We are also grateful to the Imaging and Optics, Scientific Computing, Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their technical assistance and support. Numerical simulations were performed using the computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020 research and innovation programme (grant agreement No. 665385). This work was supported by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to C.-P.H.","title":"Data associated with Keratins coordinate tissue spreading ","day":"24","author":[{"first_name":"Suyash","full_name":"Naik, Suyash","id":"2C0B105C-F248-11E8-B48F-1D18A9856A87","last_name":"Naik","orcid":"0000-0001-8421-5508"}],"article_processing_charge":"No","OA_place":"repository","oa":1,"ec_funded":1,"corr_author":"1","status":"public","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","citation":{"ista":"Naik S. 2026. Data associated with Keratins coordinate tissue spreading , Institute of Science and Technology Austria, 10.15479/AT-ISTA-21137.","short":"S. Naik, (2026).","chicago":"Naik, Suyash. “Data Associated with Keratins Coordinate Tissue Spreading .” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21137.","mla":"Naik, Suyash. Data Associated with Keratins Coordinate Tissue Spreading . Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21137.","ama":"Naik S. Data associated with Keratins coordinate tissue spreading . 2026. doi:10.15479/AT-ISTA-21137","ieee":"S. Naik, “Data associated with Keratins coordinate tissue spreading .” Institute of Science and Technology Austria, 2026.","apa":"Naik, S. (2026). Data associated with Keratins coordinate tissue spreading . Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21137"},"date_published":"2026-03-24T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"CaHe"},{"_id":"EdHa"}],"license":"https://creativecommons.org/licenses/by-sa/4.0/","file_date_updated":"2026-03-24T07:21:43Z","doi":"10.15479/AT-ISTA-21137","contributor":[{"first_name":"Yann-Edwin","contributor_type":"researcher","last_name":"Keta"},{"last_name":"Henkes","contributor_type":"supervisor","first_name":"Silke "},{"first_name":"Carl-Philipp J","contributor_type":"supervisor","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"},{"contributor_type":"supervisor","first_name":"Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"project":[{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385"},{"grant_number":"PAT 5044023","name":"Keratins in epithelial tissue spreading","_id":"8f060199-16d5-11f0-9cad-f3253b266c46"},{"_id":"252C3B08-B435-11E9-9278-68D0E5697425","name":"Nano-Analytics of Cellular Systems","call_identifier":"FWF","grant_number":"W1250-B20"}],"date_updated":"2026-06-10T09:44:10Z","date_created":"2026-02-04T16:38:02Z","_id":"21137","oa_version":"Published Version","month":"3","type":"research_data","tmp":{"image":"/images/cc_by_sa.png","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","short":"CC BY-SA (4.0)"},"has_accepted_license":"1"},{"contributor":[{"id":"334a5e40-8747-11f0-b671-ba1f5154b4b4","last_name":"Toscano","contributor_type":"researcher","first_name":"Giorgia"},{"first_name":"Anna","contributor_type":"researcher","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova"},{"id":"a3089acd-6806-11ee-bacc-f0c7d500ad20","last_name":"Singh","first_name":"Rajkumar","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"Undina","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183","last_name":"Guillerm"},{"last_name":"Lichtenecker","first_name":"Roman","contributor_type":"researcher"}],"doi":"10.15479/AT-ISTA-21284","_id":"21284","month":"2","oa_version":"Published Version","date_created":"2026-02-17T10:17:14Z","date_updated":"2026-06-10T09:28:41Z","has_accepted_license":"1","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"type":"research_data","status":"public","corr_author":"1","citation":{"ieee":"L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and Technology Austria, 2026.","apa":"Becker, L. M., & Schanda, P. (2026). Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21284","ama":"Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” 2026. doi:10.15479/AT-ISTA-21284","chicago":"Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21284.","short":"L.M. Becker, P. Schanda, (2026).","mla":"Becker, Lea Marie, and Paul Schanda. Research Data for “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.” Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21284.","ista":"Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-21284."},"date_published":"2026-02-18T00:00:00Z","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","publisher":"Institute of Science and Technology Austria","file_date_updated":"2026-02-17T10:11:14Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","department":[{"_id":"GradSch"},{"_id":"PaSc"}],"acknowledgement":"We thank Ben P. Tatman for insightful discussions. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility.","abstract":[{"text":"The advantageous characteristics attributed to the 19F nucleus have made it a popular target for NMR once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle-spinning NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilized to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical-shift assignments of all four fluorotryptophan signals in the 12 × 39 kDa large protein using a mutagenesis approach.","lang":"eng"}],"title":"Research data for \"Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants\"","author":[{"first_name":"Lea Marie","full_name":"Becker, Lea Marie","last_name":"Becker","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","orcid":"0000-0002-6401-5151"},{"full_name":"Schanda, Paul","first_name":"Paul","orcid":"0000-0002-9350-7606","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425"}],"day":"18","ddc":["541"],"oa":1,"OA_place":"repository","OA_type":"free access","article_processing_charge":"No","year":"2026","file":[{"checksum":"2d3105f26be578073b88ee1f2ea0bdb1","file_id":"21285","relation":"main_file","file_name":"Research_data.zip","content_type":"application/zip","access_level":"open_access","date_created":"2026-02-17T10:11:14Z","date_updated":"2026-02-17T10:11:14Z","file_size":36996027,"success":1,"creator":"lbecker"},{"content_type":"text/plain","access_level":"open_access","creator":"lbecker","date_created":"2026-02-17T10:11:14Z","date_updated":"2026-02-17T10:11:14Z","file_size":1993,"checksum":"e24aebcdb8856cb181cbaa02de020ddb","file_name":"README.txt","file_id":"21286","relation":"table_of_contents"}],"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}]},{"year":"2026","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"file":[{"checksum":"2f1f44e8536c2538f94a440217452c9f","file_id":"21386","relation":"source_file","file_name":"2026_Riegler_Stefan_Thesis.zip","content_type":"application/x-zip-compressed","access_level":"closed","date_updated":"2026-03-02T10:59:50Z","file_size":31430022,"date_created":"2026-03-02T10:59:50Z","creator":"sriegler"},{"checksum":"2e8dc39640bc26ae5684c944c619719b","file_id":"21387","relation":"main_file","embargo":"2027-02-27","file_name":"2026_Riegler_Stefan_Thesis.pdf","embargo_to":"open_access","content_type":"application/pdf","access_level":"closed","date_created":"2026-03-02T10:59:49Z","date_updated":"2026-03-02T10:59:49Z","file_size":11635090,"creator":"sriegler"}],"publication_identifier":{"issn":["2663-337X"]},"acknowledgement":"I would like to acknowledge the Austrian Academy of Sciences (ÖAW) and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). ","page":"185","publication_status":"published","title":"Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species","ddc":["570","575","583"],"day":"26","author":[{"id":"FF6018E0-D806-11E9-8E43-0B14E6697425","last_name":"Riegler","orcid":"0000-0003-3413-1343","full_name":"Riegler, Stefan","first_name":"Stefan"}],"supervisor":[{"last_name":"Benková","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8510-9739","first_name":"Eva","full_name":"Benková, Eva"}],"article_processing_charge":"No","OA_place":"repository","degree_awarded":"PhD","alternative_title":["ISTA Thesis"],"status":"public","corr_author":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","citation":{"short":"S. Riegler, Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species, Institute of Science and Technology Austria, 2026.","chicago":"Riegler, Stefan. “Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21360.","mla":"Riegler, Stefan. Root System Plasticity under Nutrient Limitation : Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21360.","ista":"Riegler S. 2026. Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species. Institute of Science and Technology Austria.","ieee":"S. Riegler, “Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species,” Institute of Science and Technology Austria, 2026.","apa":"Riegler, S. (2026). Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21360","ama":"Riegler S. Root system plasticity under nutrient limitation : Investigating hormonal and molecular drivers in Arabidopsis thaliana and Coffea species. 2026. doi:10.15479/AT-ISTA-21360"},"date_published":"2026-02-26T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"EvBe"}],"file_date_updated":"2026-03-02T10:59:50Z","doi":"10.15479/AT-ISTA-21360","project":[{"_id":"34afa094-11ca-11ed-8bc3-a375845a59fb","name":"Breeding for coffee and cocoa root resilience in low input farming systems based on improved rootstocks","grant_number":"101060393"}],"date_created":"2026-02-27T09:08:14Z","date_updated":"2026-06-10T09:39:12Z","oa_version":"Published Version","_id":"21360","month":"02","related_material":{"record":[{"status":"public","id":"21363","relation":"research_data"}]},"type":"dissertation","has_accepted_license":"1","tmp":{"image":"/images/cc_by_sa.png","name":"Creative Commons Attribution-ShareAlike 4.0 International Public License (CC BY-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","short":"CC BY-SA (4.0)"}},{"year":"2026","article_type":"original","external_id":{"pmid":["41851325"]},"pmid":1,"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"file":[{"checksum":"dafef9ed575b44be4263e948a47ae056","file_id":"21494","relation":"main_file","file_name":"2026_Nature_Grosjean.pdf","content_type":"application/pdf","access_level":"open_access","date_created":"2026-03-24T06:57:08Z","file_size":12245694,"date_updated":"2026-03-24T06:57:08Z","success":1,"creator":"dernst"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"ScienComp"},{"_id":"LifeSc"}],"publication":"Nature","publication_status":"published","page":"626-631","acknowledgement":"This project has received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant agreement no. 754411). We acknowledge the state of Lower Austria and the European Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility, Scientific Computing facility and Lab Support Facility. We thank the Modic group for the use of the Laue camera, T. Zauner for the photography of the experimental set-up and R. Möller for insightful discussions. Open access funding provided by Institute of Science and Technology (IST Austria).","abstract":[{"text":"Insulating oxides are among the most abundant solid materials in the universe1,2,3. Of the many ways in which they influence natural phenomena, perhaps the most consequential is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which occurs even between samples of the same oxide—yet the symmetry-breaking parameter that causes this remains unidentified11,12. Here we show that adventitious carbonaceous molecules adsorbed from the environment are the symmetry-breaking factor in same-material oxide contact electrification (CE). We use acoustic levitation to measure charge exchange between a sphere and a plate composed of identical amorphous silicon dioxide (SiO2). Although charging polarity is random for co-prepared samples, we control it with baking or plasma treatment. Observing the charge-exchange relaxation afterwards, we see dynamics over a timescale of hours and connect this directly to the presence of adventitious carbon with time-of-flight mass spectrometry, low-energy ion scattering and infrared spectroscopy. Going further, we confirm that adventitious carbon can even determine charge exchange among different oxides. Our results identify the symmetry-breaking parameter that causes insulating oxides to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6, while simultaneously highlighting an overlooked factor in CE more broadly.","lang":"eng"}],"title":"Adventitious carbon breaks symmetry in oxide contact electrification","issue":"8106","author":[{"orcid":"0000-0001-5154-417X","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","last_name":"Grosjean","full_name":"Grosjean, Galien M","first_name":"Galien M"},{"full_name":"Ostermann, Markus","first_name":"Markus","last_name":"Ostermann"},{"full_name":"Sauer, Markus","first_name":"Markus","last_name":"Sauer"},{"last_name":"Hahn","full_name":"Hahn, Michael","first_name":"Michael"},{"first_name":"Christian M.","full_name":"Pichler, Christian M.","last_name":"Pichler"},{"last_name":"Fahrnberger","first_name":"Florian","full_name":"Fahrnberger, Florian"},{"orcid":"0000-0003-0463-5794","id":"6313aec0-15b2-11ec-abd3-ed67d16139af","last_name":"Pertl","first_name":"Felix","full_name":"Pertl, Felix"},{"first_name":"Daniel","full_name":"Balazs, Daniel","orcid":"0000-0001-7597-043X","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","last_name":"Balazs"},{"full_name":"Link, Mason M.","first_name":"Mason M.","last_name":"Link"},{"full_name":"Kim, Seong H.","first_name":"Seong H.","last_name":"Kim"},{"last_name":"Schrader","first_name":"Devin L.","full_name":"Schrader, Devin L."},{"last_name":"Blanco","full_name":"Blanco, Adriana","first_name":"Adriana"},{"first_name":"Francisco","full_name":"Gracia, Francisco","last_name":"Gracia"},{"full_name":"Mujica, Nicolás","first_name":"Nicolás","last_name":"Mujica"},{"first_name":"Scott R","full_name":"Waitukaitis, Scott R","last_name":"Waitukaitis","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2299-3176"}],"day":"18","ddc":["540"],"OA_place":"publisher","oa":1,"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","corr_author":"1","status":"public","ec_funded":1,"citation":{"short":"G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger, F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia, N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.","chicago":"Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-025-10088-w.","mla":"Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp. 626–31, doi:10.1038/s41586-025-10088-w.","ista":"Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 651(8106), 626–631.","ieee":"G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide contact electrification,” Nature, vol. 651, no. 8106. Springer Nature, pp. 626–631, 2026.","apa":"Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger, F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w","ama":"Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w"},"date_published":"2026-03-18T00:00:00Z","intvolume":" 651","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publisher":"Springer Nature","file_date_updated":"2026-03-24T06:57:08Z","department":[{"_id":"ScWa"},{"_id":"GradSch"},{"_id":"LifeSc"}],"doi":"10.1038/s41586-025-10088-w","_id":"21485","month":"03","oa_version":"Published Version","date_updated":"2026-04-28T12:06:01Z","date_created":"2026-03-23T15:04:00Z","quality_controlled":"1","volume":651,"project":[{"call_identifier":"H2020","grant_number":"949120","_id":"0aa60e99-070f-11eb-9043-a6de6bdc3afa","name":"Tribocharge: a multi-scale approach to an enduring problem in physics"},{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020"}],"related_material":{"link":[{"url":"https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/","relation":"press_release","description":"News on ISTA website"}]},"has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","type":"journal_article"},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","PlanS_conform":"1","type":"journal_article","_id":"21490","month":"03","oa_version":"Published Version","volume":36,"date_created":"2026-03-23T15:11:16Z","quality_controlled":"1","date_updated":"2026-03-24T08:36:40Z","project":[{"_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681"},{"grant_number":"E271","_id":"bd906599-d553-11ed-ba76-abf8547645d7","name":"Identification of a novel regulator in auxin canalization"}],"doi":"10.1016/j.cub.2026.02.023","file_date_updated":"2026-03-24T08:34:37Z","department":[{"_id":"JiFr"}],"publisher":"Elsevier","date_published":"2026-03-23T00:00:00Z","citation":{"ama":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023","ieee":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology, vol. 36, no. 6. Elsevier, p. 1468–1480.e6, 2026.","apa":"Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026). Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.023","ista":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 36(6), 1468–1480.e6.","short":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology 36 (2026) 1468–1480.e6.","chicago":"Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński, and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.023.","mla":"Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no. 6, Elsevier, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 36","corr_author":"1","status":"public","oa":1,"OA_place":"publisher","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","issue":"6","author":[{"first_name":"Mingyue","full_name":"Li, Mingyue","last_name":"Li","id":"01f96916-0235-11eb-9379-a323192643b7"},{"full_name":"Rydza, Nikola","first_name":"Nikola","last_name":"Rydza"},{"full_name":"Mazur, Ewa","first_name":"Ewa","last_name":"Mazur"},{"id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","last_name":"Molnar","first_name":"Gergely","full_name":"Molnar, Gergely"},{"last_name":"Nodzyński","first_name":"Tomasz","full_name":"Nodzyński, Tomasz"},{"full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596"}],"day":"23","ddc":["580"],"abstract":[{"lang":"eng","text":"Auxin canalization is a self-organizing process that governs the flexible formation of vasculature by reinforcing the formation of auxin transport channels. A key prerequisite is the feedback between auxin signaling and directional auxin transport, mediated by PIN transporters. Despite the developmental importance of canalization, the molecular components linking auxin perception to the regulation of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel and essential component of auxin canalization that links intracellular auxin signaling with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23 transcriptional auxin signaling. tow mutants exhibit defects in regeneration and de novo vasculature formation, along with impaired formation of polarized, PIN-expressing auxin channels. At the subcellular level, these mutants display disrupted auxin-induced PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes predominantly to the plasma membrane, where it interacts with receptor-like kinases involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at the cell surface. Together, our findings identify TOW as a molecular link between intracellular and cell surface auxin signaling mechanisms that converge on PIN trafficking and polarity, providing new insights into how auxin signaling regulates directional auxin transport for the self-organizing formation of vasculature during flexible plant development."}],"title":"Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization","publication_status":"published","page":"1468-1480.e6","acknowledgement":"We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9 system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof. Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions, and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging & Optics Facility, and the Lab Support Facility at the Institute of Science and Technology Austria. This research was supported by the Scientific Service Units (SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The work conducted by the Friml group was funded by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS) and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant Sciences Core Facility of CEITEC Masaryk University. E.M. received support from the National Science Centre (NCN), Poland, through the OPUS call within the Weave programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes Amos Comenius.","publication":"Current Biology","publication_identifier":{"issn":["0960-9822"]},"file":[{"content_type":"application/pdf","access_level":"open_access","file_size":12986894,"date_created":"2026-03-24T08:34:37Z","date_updated":"2026-03-24T08:34:37Z","creator":"dernst","success":1,"checksum":"fe6c41fdab58a55df5f2a5860c02acdc","file_id":"21496","relation":"main_file","file_name":"2026_CurrentBiology_Li.pdf"}],"acknowledged_ssus":[{"_id":"MassSpec"},{"_id":"Bio"},{"_id":"LifeSc"}],"pmid":1,"external_id":{"pmid":["41831441"]},"language":[{"iso":"eng"}],"year":"2026","article_type":"original"},{"publication":"Journal of Materials Chemistry B","acknowledged_ssus":[{"_id":"LifeSc"}],"publication_identifier":{"eissn":["2050-7518"],"issn":["2050-750X"]},"language":[{"iso":"eng"}],"pmid":1,"external_id":{"pmid":["41958432"]},"article_type":"original","year":"2026","article_processing_charge":"No","OA_type":"closed access","day":"10","author":[{"first_name":"Moumita","full_name":"Mondal, Moumita","last_name":"Mondal"},{"last_name":"Ghorai","first_name":"Pravat","full_name":"Ghorai, Pravat"},{"last_name":"Samadder","first_name":"Asmita","full_name":"Samadder, Asmita"},{"last_name":"Freunberger","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","full_name":"Freunberger, Stefan Alexander"},{"last_name":"Banerjee","first_name":"Priyabrata","full_name":"Banerjee, Priyabrata"}],"title":"H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis","abstract":[{"lang":"eng","text":"Hydrogen peroxide (H2O2) is a crucial member of the reactive oxygen species (ROS) family, playing roles in cellular signalling and immune responses in human health. Moreover, it is a potential biomarker of diabetes when present in aberrant concentrations. Therefore, monitoring trace levels of H2O2 has become a research hotspot for analytical and sensor chemists. In this context, we report a rhodamine-based fluorescent probe (RN), which shows excellent fluorescent enhancement at 555 nm upon the addition of H2O2 along with a low limit of detection (LOD) of 0.67 ppm and fast response (∼2 min). The probe is highly selective for H2O2, showing no fluorescence enhancement with other ROS. RN is synthesised in a one-pot chemical reaction using rhodamine 6G (R6G) and 4,7,10-trioxa-1,13-tridecanediamine (TTDA). H2O2 detection in pre-treated milk samples proves its real-world viability. We found that RN shows low cytotoxicity, which allowed us to successfully explore its potential to monitor H2O2 generation in a diabetic L929 skin cell line and diabetic mice liver tissue. This result demonstrates promising features for assessing early diabetic progression through fluorescence imaging."}],"acknowledgement":"MM acknowledges the Government of India for DST-INSPIRE\r\nfellowship [IF200389] and Federal Ministry of Education, Science and Research (BMBWF) and the OeAD – Austria’s Agency for Education and Internationalisation for an Ernst Mach Grant, weltweit (grant number MPC-2024-01518) for research internship at ISTA. The Scientific Service Units of ISTA supported this research through resources provided by the Lab Support Facility. PG acknowledges the ANRF, India, for his NPDF fellowship (File no. PDF/2022/001960). PB acknowledges ANRF, India, for the SERB-CRG sponsored project GAP-240712 (vide reference no. CRG/2022/001679).","publication_status":"epub_ahead","department":[{"_id":"StFr"}],"publisher":"Royal Society of Chemistry","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. 2026. H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of Materials Chemistry B.","mla":"Mondal, Moumita, et al. “H2O2 Responsive Rhodamine-Based Probe for Monitoring Early-Stage Diabetes Diagnosis.” Journal of Materials Chemistry B, Royal Society of Chemistry, 2026, doi:10.1039/d5tb02687c.","chicago":"Mondal, Moumita, Pravat Ghorai, Asmita Samadder, Stefan Alexander Freunberger, and Priyabrata Banerjee. “H2O2 Responsive Rhodamine-Based Probe for Monitoring Early-Stage Diabetes Diagnosis.” Journal of Materials Chemistry B. Royal Society of Chemistry, 2026. https://doi.org/10.1039/d5tb02687c.","short":"M. Mondal, P. Ghorai, A. Samadder, S.A. Freunberger, P. Banerjee, Journal of Materials Chemistry B (2026).","ama":"Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of Materials Chemistry B. 2026. doi:10.1039/d5tb02687c","apa":"Mondal, M., Ghorai, P., Samadder, A., Freunberger, S. A., & Banerjee, P. (2026). H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of Materials Chemistry B. Royal Society of Chemistry. https://doi.org/10.1039/d5tb02687c","ieee":"M. Mondal, P. Ghorai, A. Samadder, S. A. Freunberger, and P. Banerjee, “H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis,” Journal of Materials Chemistry B. Royal Society of Chemistry, 2026."},"date_published":"2026-04-10T00:00:00Z","status":"public","corr_author":"1","type":"journal_article","scopus_import":"1","date_updated":"2026-04-16T05:44:49Z","date_created":"2026-04-13T07:45:26Z","quality_controlled":"1","_id":"21730","oa_version":"None","month":"04","doi":"10.1039/d5tb02687c"},{"acknowledgement":"We would like to thank the members of the Sweeney Lab, Mario de Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript. We are also grateful to Tom Jessell and Chris Kintner for their scientific insight and mentorship during the conception of this project. It would also have not been possible without the technical support of the Aquatics and Imaging and Optics Facility support teams (ISTA). We thank Martin Estermann for preparing the initial draft of the graphical abstract and Niki Barolini for the final version. In addition, we thank our funding sources for providing the resources to do these experiments: GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.), Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858 (to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC) (to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472 (to Z.H.), and Project A.L.S. (to S.B.-M.).","publication_status":"published","title":"Multifold increase in spinal inhibitory cell types with emergence of limb movement","abstract":[{"lang":"eng","text":"As vertebrates transitioned from water to land, locomotion shifted from undulatory swimming to limb-based movement. How spinal circuits and their cell types evolved to support this transition remains unclear. We leverage frog metamorphosis, which recapitulates this transition within a single organism, to define how spinal circuits generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons. As limbs develop and their movement complexifies, spinal circuits expand in neuron number and subtype diversity. This expansion is most pronounced for V1 inhibitory neurons, which increase ∼70-fold and diversify into transcriptionally distinct subtypes. Disrupting transcription factors defining emerging motor and V1 populations reveals molecular segregation between swim and limb circuits, highlighting the role of subtype diversity in motor coordination. A multifold increase in inhibitory neuron diversity thus underlies the tail-to-limb locomotor transition, providing a framework for spinal circuit adaptation during vertebrate evolution."}],"day":"28","ddc":["570"],"author":[{"last_name":"Vijatovic","id":"cf391e77-ec3c-11ea-a124-d69323410b58","first_name":"David","full_name":"Vijatovic, David"},{"last_name":"Toma","id":"2f73f876-f128-11eb-9611-b96b5a30cb0e","first_name":"Florina Alexandra ","full_name":"Toma, Florina Alexandra "},{"first_name":"Y","full_name":"Ignatyev, Y","last_name":"Ignatyev"},{"full_name":"Harrington, Zoe P","first_name":"Zoe P","id":"a8144562-32c9-11ee-b5ce-d9800628bda2","last_name":"Harrington","orcid":"0009-0008-0158-4032"},{"last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M","full_name":"Sommer, Christoph M"},{"full_name":"Hauschild, Robert","first_name":"Robert","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild"},{"first_name":"Matthijs Geert","full_name":"Smits, Matthijs Geert","last_name":"Smits","id":"7a231d52-e216-11ee-a0bb-8acd55f8f1f0"},{"full_name":"Dalla Vecchia, Marco","first_name":"Marco","last_name":"Dalla Vecchia","id":"02a7a869-ff06-11ed-a87f-86649d6077e5"},{"full_name":"Trevisan, Alexandra J.","first_name":"Alexandra J.","last_name":"Trevisan"},{"first_name":"Phillip","full_name":"Chapman, Phillip","last_name":"Chapman"},{"first_name":"Mara","full_name":"Julseth, Mara","last_name":"Julseth","id":"1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1"},{"last_name":"Brenner-Morton","first_name":"Susan","full_name":"Brenner-Morton, Susan"},{"full_name":"Gabitto, Mariano I.","first_name":"Mariano I.","last_name":"Gabitto"},{"last_name":"Dasen","first_name":"Jeremy S.","full_name":"Dasen, Jeremy S."},{"full_name":"Bikoff, Jay B.","first_name":"Jay B.","last_name":"Bikoff"},{"first_name":"Lora Beatrice Jaeger","full_name":"Sweeney, Lora Beatrice Jaeger","last_name":"Sweeney","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","orcid":"0000-0001-9242-5601"}],"issue":"4","article_processing_charge":"Yes","OA_type":"gold","OA_place":"publisher","oa":1,"article_type":"original","year":"2026","language":[{"iso":"eng"}],"external_id":{"pmid":["41964955 "]},"pmid":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"file":[{"access_level":"open_access","content_type":"application/pdf","creator":"dernst","success":1,"date_created":"2026-05-04T12:20:10Z","date_updated":"2026-05-04T12:20:10Z","file_size":14925958,"checksum":"0d26cdb5b8d8dec3a911d8261a65cdef","file_name":"2026_CellReports_Vijatovic.pdf","relation":"main_file","file_id":"21795"}],"publication_identifier":{"issn":["2639-1856"],"eissn":["2211-1247"]},"publication":"Cell Reports","doi":"10.1016/j.celrep.2026.117227","project":[{"grant_number":"101041551","name":"Development and Evolution of Tetrapod Motor Circuits","_id":"ebb66355-77a9-11ec-83b8-b8ac210a4dae"},{"grant_number":"F7814","_id":"8da85f50-16d5-11f0-9cad-eab8b0ff6c9e","name":"Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb transition: cell type to connection diversity"},{"grant_number":"CZI01","name":"Tools for automation and feedback microscopy","_id":"c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473"},{"grant_number":"FTI21-D-046","_id":"bd73af52-d553-11ed-ba76-912049f0ac7a","name":"Development of V1 interneuron diversity during swim-to-walk transition of Xenopus metamorphosis"}],"scopus_import":"1","quality_controlled":"1","date_updated":"2026-05-04T12:27:06Z","volume":45,"date_created":"2026-04-19T22:07:43Z","month":"04","_id":"21746","oa_version":"Published Version","type":"journal_article","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","PlanS_conform":"1","article_number":"117227","status":"public","corr_author":"1","DOAJ_listed":"1","intvolume":" 45","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"D. Vijatovic et al., “Multifold increase in spinal inhibitory cell types with emergence of limb movement,” Cell Reports, vol. 45, no. 4. Elsevier, 2026.","apa":"Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M., Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2026.117227","ama":"Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. 2026;45(4). doi:10.1016/j.celrep.2026.117227","chicago":"Vijatovic, David, Florina Alexandra Toma, Y Ignatyev, Zoe P Harrington, Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” Cell Reports. Elsevier, 2026. https://doi.org/10.1016/j.celrep.2026.117227.","short":"D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild, M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton, M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026).","mla":"Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” Cell Reports, vol. 45, no. 4, 117227, Elsevier, 2026, doi:10.1016/j.celrep.2026.117227.","ista":"Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory cell types with emergence of limb movement. Cell Reports. 45(4), 117227."},"date_published":"2026-04-28T00:00:00Z","publisher":"Elsevier","department":[{"_id":"LoSw"},{"_id":"GradSch"},{"_id":"TiVo"},{"_id":"Bio"},{"_id":"NiBa"}],"file_date_updated":"2026-05-04T12:20:10Z"},{"OA_place":"publisher","oa":1,"OA_type":"gold","article_processing_charge":"Yes","issue":"15","author":[{"last_name":"Li","full_name":"Li, Mengyao","first_name":"Mengyao"},{"last_name":"Zhao","full_name":"Zhao, Xueke","first_name":"Xueke"},{"last_name":"Zhang","full_name":"Zhang, Yu","first_name":"Yu"},{"first_name":"Jing","full_name":"Yu, Jing","last_name":"Yu"},{"full_name":"Liu, Xuyang","first_name":"Xuyang","last_name":"Liu"},{"full_name":"Jia, Mochen","first_name":"Mochen","last_name":"Jia"},{"last_name":"Song","full_name":"Song, Hongzhang","first_name":"Hongzhang"},{"last_name":"Wang","first_name":"Dongyang","full_name":"Wang, Dongyang"},{"first_name":"Jordi","full_name":"Arbiol, Jordi","last_name":"Arbiol"},{"first_name":"Maria","full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez"},{"last_name":"Shan","first_name":"Chongxin","full_name":"Shan, Chongxin"},{"last_name":"Cabot","first_name":"Andreu","full_name":"Cabot, Andreu"},{"full_name":"Wang, Ziyu","first_name":"Ziyu","last_name":"Wang"}],"day":"10","ddc":["530"],"abstract":[{"lang":"eng","text":"Liquid-like superionic conductors, with highly mobile ions in a rigid framework, offer intrinsically low lattice thermal conductivity without compromising electronic transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its low carrier concentration limits the power factor. Here, interstitial Ag atoms raise the Fermi level into the conduction band, substantially increasing the electron concentration. Simultaneously, the formation of a secondary Ag2Se phase generates lattice distortions that enhance phonon scattering. A pronounced mismatch between electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples charge and heat transport, enabling concurrent suppression of κL and retention of high electrical conductivity. This coupled electronic-phononic modulation yields a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins, with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves 6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy for high-performance midtemperature thermoelectrics."}],"title":"Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6","publication_status":"published","acknowledgement":"The Scientific Service Units (SSU) of ISTA supported this research through resources provided by the Lab Support Facility (LSF). This work was supported by the National Key R&D Program of China grant 2024YFE0105200 (to C.S.), National Natural Science Foundation of China grant 12504038 (to M.L.), China Postdoctoral Science Foundation grant 2023M743151 (to M.L.), Natural Science Foundation of Henan Province grant 252300421763 (to M.L.), Key Scientific Research Project of Higher Education Institutions in Henan Province grant 25A140004 (to M.L.), National Natural Science Foundation of China grant 12204156 (to D.W.), China Postdoctoral Science Foundation grant 2023TQ0315 and 2023 M743224 (to D.W.), Generalitat de Catalunya grant 2021SGR00457 (to J.A.), and European Regional Development Fund grants ENE2016-77798-C4-3-R, PID2020-116093RB-C43, and AEI/10.13039/501100011033 (to A.C.). This work also was financially supported by ISTA and the Werner Siemens Foundation (to M.I.).","publication":"Science Advances","publication_identifier":{"eissn":["2375-2548"]},"file":[{"content_type":"application/pdf","access_level":"open_access","date_created":"2026-05-06T06:06:26Z","date_updated":"2026-05-06T06:06:26Z","file_size":3727993,"creator":"dernst","success":1,"checksum":"9bd4546a23f218972f83164fb21003e1","file_id":"21802","relation":"main_file","file_name":"2026_ScienceAdv_Li.pdf"}],"acknowledged_ssus":[{"_id":"LifeSc"}],"external_id":{"pmid":["41961944"]},"pmid":1,"language":[{"iso":"eng"}],"year":"2026","article_type":"original","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"has_accepted_license":"1","type":"journal_article","_id":"21750","oa_version":"Published Version","month":"04","date_updated":"2026-05-06T06:08:27Z","quality_controlled":"1","date_created":"2026-04-19T22:07:47Z","volume":12,"scopus_import":"1","project":[{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"}],"doi":"10.1126/sciadv.aec9073","file_date_updated":"2026-05-06T06:06:26Z","department":[{"_id":"MaIb"}],"publisher":"AAAS","citation":{"mla":"Li, Mengyao, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning Enable High Thermoelectric Performance in Ag8SnSe6.” Science Advances, vol. 12, no. 15, eaec9073, AAAS, 2026, doi:10.1126/sciadv.aec9073.","chicago":"Li, Mengyao, Xueke Zhao, Yu Zhang, Jing Yu, Xuyang Liu, Mochen Jia, Hongzhang Song, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning Enable High Thermoelectric Performance in Ag8SnSe6.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aec9073.","short":"M. Li, X. Zhao, Y. Zhang, J. Yu, X. Liu, M. Jia, H. Song, D. Wang, J. Arbiol, M. Ibáñez, C. Shan, A. Cabot, Z. Wang, Science Advances 12 (2026).","ista":"Li M, Zhao X, Zhang Y, Yu J, Liu X, Jia M, Song H, Wang D, Arbiol J, Ibáñez M, Shan C, Cabot A, Wang Z. 2026. Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances. 12(15), eaec9073.","apa":"Li, M., Zhao, X., Zhang, Y., Yu, J., Liu, X., Jia, M., … Wang, Z. (2026). Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aec9073","ieee":"M. Li et al., “Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6,” Science Advances, vol. 12, no. 15. AAAS, 2026.","ama":"Li M, Zhao X, Zhang Y, et al. Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances. 2026;12(15). doi:10.1126/sciadv.aec9073"},"date_published":"2026-04-10T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 12","DOAJ_listed":"1","status":"public","article_number":"eaec9073"},{"publisher":"AAAS","department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"article_number":"eaea6343","status":"public","corr_author":"1","ec_funded":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 392","date_published":"2026-04-16T00:00:00Z","citation":{"ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026).","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science. AAAS, 2026. https://doi.org/10.1126/science.aea6343.","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” Science, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:10.1126/science.aea6343.","ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 2026;392(6795). doi:10.1126/science.aea6343","ieee":"B. L. Springstein et al., “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” Science, vol. 392, no. 6795. AAAS, 2026.","apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. AAAS. https://doi.org/10.1126/science.aea6343"},"type":"journal_article","doi":"10.1126/science.aea6343","scopus_import":"1","project":[{"name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020"},{"grant_number":"101076260","_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","name":"A molecular atlas of Actin filament IDentities in the cell motility machinery"}],"month":"04","_id":"21762","oa_version":"None","date_updated":"2026-04-28T13:29:05Z","quality_controlled":"1","volume":392,"date_created":"2026-04-26T22:01:46Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"publication":"Science","year":"2026","article_type":"original","pmid":1,"external_id":{"pmid":["41990175"]},"language":[{"iso":"eng"}],"author":[{"orcid":"0000-0002-3461-5391","last_name":"Springstein","id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083","full_name":"Springstein, Benjamin L","first_name":"Benjamin L"},{"orcid":"0000-0003-2311-2112","last_name":"Javoor","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","first_name":"Manjunath","full_name":"Javoor, Manjunath"},{"last_name":"Megrian","first_name":"Daniela","full_name":"Megrian, Daniela"},{"full_name":"Hajdu, Roman","first_name":"Roman","last_name":"Hajdu","id":"ffab949d-133f-11ed-8f02-94de21ace503"},{"full_name":"Hanke, Dustin M.","first_name":"Dustin M.","last_name":"Hanke"},{"orcid":"0000-0002-9561-1239","last_name":"Zens","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","first_name":"Bettina","full_name":"Zens, Bettina"},{"full_name":"Weiss, Gregor L.","first_name":"Gregor L.","last_name":"Weiss"},{"orcid":"0000-0003-4790-8078","last_name":"Schur","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian Km","full_name":"Schur, Florian Km"},{"first_name":"Martin","full_name":"Loose, Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87","last_name":"Loose"}],"day":"16","issue":"6795","OA_type":"closed access","article_processing_charge":"No","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","publication_status":"published","title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","abstract":[{"text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.","lang":"eng"}]},{"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"file":[{"file_id":"21832","relation":"main_file","file_name":"2026_Science_Kulich_accepted.pdf","checksum":"eb5b29247832ecdc53c8146da0509bbe","date_updated":"2026-05-07T05:54:43Z","file_size":6150733,"date_created":"2026-05-07T05:54:43Z","success":1,"creator":"dernst","content_type":"application/pdf","access_level":"open_access"}],"publication":"Science","article_type":"original","year":"2026","language":[{"iso":"eng"}],"external_id":{"pmid":["41990180"]},"pmid":1,"issue":"6795","ddc":["580"],"day":"16","author":[{"first_name":"Ivan","full_name":"Kulich, Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54","last_name":"Kulich"},{"last_name":"Vladimirtsev","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d","full_name":"Vladimirtsev, Dmitrii","first_name":"Dmitrii"},{"full_name":"Randuch, Marek","first_name":"Marek","id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","last_name":"Randuch"},{"first_name":"Shiqiang","full_name":"Gao, Shiqiang","last_name":"Gao"},{"last_name":"Citterico","first_name":"Matteo","full_name":"Citterico, Matteo"},{"full_name":"Konrad, Kai R.","first_name":"Kai R.","last_name":"Konrad"},{"first_name":"Georg","full_name":"Nagel, Georg","last_name":"Nagel"},{"last_name":"Wrzaczek","full_name":"Wrzaczek, Michael","first_name":"Michael"},{"last_name":"Cascaro","first_name":"Léa","full_name":"Cascaro, Léa"},{"first_name":"Pauline","full_name":"Vinet, Pauline","last_name":"Vinet"},{"first_name":"Pauline","full_name":"Durand, Pauline","last_name":"Durand"},{"first_name":"Atef","full_name":"Asnacios, Atef","last_name":"Asnacios"},{"first_name":"Lokesh","full_name":"Verma, Lokesh","last_name":"Verma"},{"last_name":"Bennett","first_name":"Malcolm J.","full_name":"Bennett, Malcolm J."},{"first_name":"Bipin K.","full_name":"Pandey, Bipin K.","last_name":"Pandey"},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Friml, Jiří","first_name":"Jiří"}],"oa":1,"OA_place":"repository","article_processing_charge":"No","OA_type":"green","page":"296-300","publication_status":"published","acknowledgement":"We gratefully acknowledge the Lab Support Facility (LSF) and the Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility (University of Nottingham) for support with imaging and the Growth Facility (IPMB) for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing of Arabidopsis mini-soil columns.\r\nThis project received funding from the European Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B). I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030 and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government through its “Investments for the Future” program and also by the projects “Mecha-Nuc” ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université Paris-Saclay. Phytohormonal analysis was performed using the service laboratory funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This research was funded in whole or in part by the Austrian Science Fund (P 37051-B) and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required, the author will make the Author Accepted Manuscript (AAM) version available under a CC BY public copyright license.","abstract":[{"lang":"eng","text":"Reactive oxygen species (ROS) have been implicated in multiple signaling processes in plants, but the underlying mechanisms and roles remain enigmatic. In this study, we developed a method of live imaging of apoplastic ROS at the root surface. Distinct signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts. Genetic and optogenetic manipulations of Arabidopsis identified calcium transients as necessary and sufficient for ROS bursts through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS bursts are not required, but they do limit gravity-induced root bending. Root bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH oxidase activation. The resulting ROS production stiffens cell walls to facilitate soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility and stiffness to navigate soil."}],"title":"Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation","publisher":"AAAS","department":[{"_id":"JiFr"},{"_id":"GradSch"}],"file_date_updated":"2026-05-07T05:54:43Z","status":"public","corr_author":"1","date_published":"2026-04-16T00:00:00Z","citation":{"apa":"Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad, K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. AAAS. https://doi.org/10.1126/science.adu8197","ieee":"I. Kulich et al., “Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation,” Science, vol. 392, no. 6795. AAAS, pp. 296–300, 2026.","ama":"Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 2026;392(6795):296-300. doi:10.1126/science.adu8197","mla":"Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science, vol. 392, no. 6795, AAAS, 2026, pp. 296–300, doi:10.1126/science.adu8197.","chicago":"Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science. AAAS, 2026. https://doi.org/10.1126/science.adu8197.","short":"I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad, G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma, M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300.","ista":"Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ, Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 392(6795), 296–300."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 392","has_accepted_license":"1","type":"journal_article","doi":"10.1126/science.adu8197","volume":392,"quality_controlled":"1","date_created":"2026-04-26T22:01:47Z","date_updated":"2026-05-07T06:20:07Z","_id":"21763","month":"04","oa_version":"Accepted Version","project":[{"grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants"},{"name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","grant_number":"P37051"}],"scopus_import":"1"},{"article_number":"e70417","corr_author":"1","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 368","date_published":"2026-05-05T00:00:00Z","citation":{"mla":"Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417.","chicago":"Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417.","short":"A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced Synthesis & Catalysis 368 (2026).","ista":"Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9), e70417.","apa":"Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber, B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.70417","ieee":"A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis, vol. 368, no. 9. Wiley, 2026.","ama":"Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417"},"publisher":"Wiley","department":[{"_id":"BaPi"},{"_id":"GradSch"}],"file_date_updated":"2026-05-07T07:29:24Z","doi":"10.1002/adsc.70417","project":[{"grant_number":"PAT 1250924","name":"Photoactive ligands for transformative nickel catalysis","_id":"8f1d607d-16d5-11f0-9cad-ab453295ba5e"}],"scopus_import":"1","quality_controlled":"1","date_created":"2026-05-03T22:01:36Z","date_updated":"2026-05-07T07:33:33Z","volume":368,"_id":"21776","month":"05","oa_version":"Published Version","type":"journal_article","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","PlanS_conform":"1","article_type":"original","year":"2026","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"MassSpec"},{"_id":"NMR"},{"_id":"M-Shop"}],"file":[{"checksum":"afe9752977898642c903abdc70b4a283","file_name":"2026_AdvSynthCatal_Petrik.pdf","relation":"main_file","file_id":"21833","access_level":"open_access","content_type":"application/pdf","creator":"dernst","success":1,"file_size":437184,"date_created":"2026-05-07T07:29:24Z","date_updated":"2026-05-07T07:29:24Z"}],"publication_identifier":{"eissn":["1615-4169"],"issn":["1615-4150"]},"publication":"Advanced Synthesis & Catalysis","acknowledgement":"We gratefully acknowledge ISTA for generous financial support. B.P. acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support. This research was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility, and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul J. and Margaret M. Bender. Open Access funding provided by Institute of Science and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT 1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003) and (CHE-1048642).","publication_status":"published","title":"Facile access to N-substituted pyridyl ligands","abstract":[{"text":"Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications.","lang":"eng"}],"day":"05","ddc":["540"],"author":[{"id":"e273d403-329f-11ee-a353-8c34c056f8ed","last_name":"Petrik","full_name":"Petrik, Adam","first_name":"Adam"},{"full_name":"Bena, Aleksander","first_name":"Aleksander","last_name":"Bena","id":"4197c39e-e8ec-11ed-86cb-afed934cd664"},{"full_name":"Baunis, Haralds","first_name":"Haralds","id":"2eea55ec-e8ec-11ed-86cb-d9c76787acfe","last_name":"Baunis"},{"full_name":"Kelch, Riley M.","first_name":"Riley M.","last_name":"Kelch"},{"first_name":"Tehshik P.","full_name":"Yoon, Tehshik P.","last_name":"Yoon"},{"orcid":"0000-0001-8689-388X","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus"}],"issue":"9","article_processing_charge":"Yes (via OA deal)","OA_type":"hybrid","oa":1,"OA_place":"publisher"},{"project":[{"grant_number":"101089099","name":"Cavity Quantum Electro Optics: Microwave photonics with nonclassical states","_id":"bdadfa0d-d553-11ed-ba76-fb85edbd456a"},{"grant_number":"899354","call_identifier":"H2020","name":"Quantum Local Area Networks with Superconducting Qubits","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A"},{"name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","grant_number":"758053","call_identifier":"H2020"},{"name":"Integrated optical coupling for low loss electro-optic interconnects","_id":"5b807754-ab3d-11f0-914f-ff8c34502cc9","grant_number":"101248662"},{"_id":"91aaf765-16d5-11f0-9cad-a8e7e44cccb7","name":"Cavity-Integrated Electro-Optics: Measuring, Converting and Manipulating Microwaves with Light","grant_number":"101187231"},{"name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits","_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","grant_number":"F07105"},{"grant_number":"101080139","_id":"bdb7cfc1-d553-11ed-ba76-d2eaab167738","name":"Open Superconducting Quantum Computers (OpenSuperQPlus)"},{"_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A","name":"NOMIS Fellowship Program"}],"date_created":"2026-05-12T09:04:02Z","date_updated":"2026-05-20T13:35:43Z","_id":"21863","month":"05","oa_version":"Published Version","doi":"10.15479/AT-ISTA-21863","type":"dissertation","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"related_material":{"record":[{"relation":"part_of_dissertation","id":"19073","status":"public"},{"status":"public","id":"21870","relation":"part_of_dissertation"}]},"keyword":["Superconducting qubits","Quantum optics","Single photons and quantum effects","Nonlinear optics"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","date_published":"2026-05-12T00:00:00Z","citation":{"ista":"Werner T. 2026. Interfacing superconducting qubits with optical photons. Institute of Science and Technology Austria.","chicago":"Werner, Thomas. “Interfacing Superconducting Qubits with Optical Photons.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21863.","short":"T. Werner, Interfacing Superconducting Qubits with Optical Photons, Institute of Science and Technology Austria, 2026.","mla":"Werner, Thomas. Interfacing Superconducting Qubits with Optical Photons. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21863.","ama":"Werner T. Interfacing superconducting qubits with optical photons. 2026. doi:10.15479/AT-ISTA-21863","ieee":"T. Werner, “Interfacing superconducting qubits with optical photons,” Institute of Science and Technology Austria, 2026.","apa":"Werner, T. (2026). Interfacing superconducting qubits with optical photons. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21863"},"alternative_title":["ISTA Thesis"],"ec_funded":1,"status":"public","corr_author":"1","department":[{"_id":"GradSch"},{"_id":"JoFi"}],"file_date_updated":"2026-05-15T15:54:06Z","publisher":"Institute of Science and Technology Austria","title":"Interfacing superconducting qubits with optical photons","abstract":[{"text":"Atoms and photons, two things so different but yet so alike. The former, the building block of matter, something we learn about in school and imagine it as some tiny marbles encircled by other tinier marbles. The latter, an electromagnetic wave, a light particle or an excitation of the electromagnetic field. Quantum mechanics tells us about the properties of these two entities. And even if it sounds, looks and writes counter-intuitive, it has proven right for over a century now.\r\n\r\nIn this work, I elaborate on how we tested the laws of quantum mechanics and how we used them learn more about the tiny building blocks of nature and the fields they use to talk to each other. The atoms we use, are artificial. Superconducting qubits, small electrical circuits with quantized energy levels behave like electrons that transition between different orbitals in an atom. One of the qubits' advantages, is also a big disadvantage. We design the circuits' energy levels and fabricate them in a cleanroom. This allows for arbitrary spaced energy levels but in contrast to real atoms, prevents two superconducting qubits from being alike. Still, this qubit platform is one of the frontrunners for future quantum computing technology and testing fundamental physics due to their scalability.\r\n\r\nWe interface superconducting qubits, which operate in the GHz regime, with microwave photons. We use 3D aluminum cavities as mediators between qubits and photons. The cavities allow for non-destructive readout of the qubit state, they shield the qubits from noise at the qubit frequency and they give us an easy way to frequency-tune these joint systems.\r\n\r\nWe need to operate superconducting qubits and their cavities at millikelvin temperatures in dilution refrigerators. At higher temperatures, superconductivity suffers and even worse, the environment is filled with thermal noise photons. This poses a fundamental limitation on the scalability of superconducting qubit devices. Also connecting multiple devices in different fridges does not work over room temperature links because the microwave photons used for this purpose will be covered in noise and the quantum information they carry, will be unusable.\r\n\r\nInfrared photons do not suffer from this noise problem since there are close to zero thermal noise photons at their frequencies at room temperature. We cannot simply interface superconducting devices with optical photons due their frequency mismatch and the destructive effect of optical photons on superconductors. Therefore, we use microwave-to-optics transducers that allow to convert microwave photons into optical ones and vice-versa. The transducers that we use are macroscopic electro-optic transducers using the Pockels effect in a disk-shaped Lithium Niobate whispering gallery mode resonator. By using a strong optical pump, photons from the two frequency domains experience a beam-splitter interaction and get converted from one to the other.\r\n\r\nWe measure the generated optical photons using elaborate optical setups, optical heterodyning and single photon detectors to gain knowledge about the qubit state or the converted microwave photons. Bridging the microwave and the optical world allows us to take advantage of both of their strengths but it also requires deep knowledge about both of their working principles.\r\n\r\nIn this work, we describe two experiments that our group conducted to showcase the opportunities that arise from interfacing superconducting qubits with optical photons but also the pitfalls, one may encounter on the way.\r\n\r\nIn the first experiment, we managed to all-optically read out a superconducting qubit. We show that the assignment fidelity, the probability that a measurement of the qubit state matches the prepared state, is close to equal for all-optical, microwave-to-optics and conventional microwave readout. We show T1 and T2 measurements for all three readout types and give an analysis of the noise caused by the optics. Finally, we show that the infrared light does not affect the qubit performance in a negative way but that the heating it causes does. This is an important insight that we used in the next experiment.\r\n\r\nThe second experiment is the upconversion of itinerant single microwave photons to the optical domain. We show that we can generate single microwave photons from a qubit-cavity system. We upconvert these single photons, measure them with a single photon detector and reconstruct their shape. By conducting a single photon Rabi measurement, we show correlations between the microwave and the optical domain. And by thorough signal-to-noise measurements and noise analysis, we find that we can generate single infrared photons with high signal-to-noise ratio 5.1 and low transducer added noise (<0.012 quanta). We show that this measurement creates a path towards entanglement of a superconducting qubit and an optical photon and what parameters need to be improved to achieve it. Additionally, this experiment is a proof of principle for an on-demand infrared single photon source. More generally, it allows to link microwave quantum technology in general to the optical domain.","lang":"eng"}],"acknowledgement":"The author of this work was supported by the European Research Council under grant no.\r\n101089099 (ERC CoG cQEO) and the European Union’s Horizon 2020 research and innovation\r\nprogram under grant no. 899354 (FETopen SuperQuLAN).\r\nThis work was also supported by the European Research Council under grant nos. 758053\r\n(ERC StG QUNNECT), 101248662 (ERC POC CoupledEOT), and the European Innovation\r\nCouncil no. 101187231 (PathfinderOpen CIELO). This research was funded in whole or in part\r\nby the Austrian Science Fund (FWF) [10.55776/F71]. For open access purposes, the author\r\nhas applied a CC BY public copyright license to any author accepted manuscript version arising\r\nfrom this submission.\r\niii\r\nMy co-authors in the works mentioned later acknowledge generous support from the ISTFELLOW program, the NOMIS-ISTA fellowship, the Horizon Europe Program HORIZONCL4-2022-QUANTUM-01-SGA via Project No. 101113946 OpenSuperQPlus100 and a DOC fellowship of the Austrian Academy of Sciences at IST Austria.\r\n","page":"97","publication_status":"published","article_processing_charge":"No","oa":1,"OA_place":"publisher","degree_awarded":"PhD","day":"12","ddc":["530","537","539"],"author":[{"orcid":"0009-0001-2346-5236","last_name":"Werner","id":"1fcd8497-dba3-11ea-a45e-c6fbd715f7c7","full_name":"Werner, Thomas","first_name":"Thomas"}],"supervisor":[{"first_name":"Johannes M","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","last_name":"Fink","orcid":"0000-0001-8112-028X"}],"language":[{"iso":"eng"}],"year":"2026","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"},{"_id":"LifeSc"},{"_id":"SSU"}],"file":[{"file_name":"2026_Werner_Thomas_Thesis.pdf","file_id":"21879","relation":"main_file","checksum":"a5b4d8dba83f96e955a3625c0eebee98","creator":"twerner","file_size":9330516,"date_created":"2026-05-15T15:53:57Z","date_updated":"2026-05-15T15:53:57Z","content_type":"application/pdf","access_level":"open_access"},{"relation":"source_file","file_id":"21880","file_name":"2026_Werner_Thomas_Thesis.zip","checksum":"b41282beaacfb32472769b9e3b1758d8","date_updated":"2026-05-15T15:54:06Z","file_size":9370704,"date_created":"2026-05-15T15:54:06Z","creator":"twerner","access_level":"closed","content_type":"application/x-zip-compressed"}],"publication_identifier":{"issn":["2663-337X"]}},{"publication":"Science Advances","acknowledged_ssus":[{"_id":"MassSpec"},{"_id":"LifeSc"}],"file":[{"checksum":"75b8ef2db078652c750e34e9cd98a808","file_name":"2026_ScienceAdv_Li2.pdf","file_id":"21941","relation":"main_file","content_type":"application/pdf","access_level":"open_access","success":1,"creator":"dernst","date_created":"2026-06-02T14:33:55Z","file_size":2014452,"date_updated":"2026-06-02T14:33:55Z"}],"publication_identifier":{"eissn":["2375-2548"]},"language":[{"iso":"eng"}],"external_id":{"pmid":["42102187"]},"pmid":1,"article_type":"original","year":"2026","article_processing_charge":"Yes","OA_type":"gold","oa":1,"OA_place":"publisher","ddc":["580"],"day":"08","author":[{"last_name":"Li","id":"01f96916-0235-11eb-9379-a323192643b7","full_name":"Li, Mingyue","first_name":"Mingyue"},{"first_name":"Monika","full_name":"Chodasiewicz, Monika","last_name":"Chodasiewicz"},{"last_name":"Muraleedharan","first_name":"Malavika","full_name":"Muraleedharan, Malavika"},{"last_name":"Lopez","first_name":"Israel M.","full_name":"Lopez, Israel M."},{"last_name":"Gorka","full_name":"Gorka, Michal","first_name":"Michal"},{"full_name":"Kerber, Olga","first_name":"Olga","last_name":"Kerber"},{"full_name":"Alotaibi, Saqer S.","first_name":"Saqer S.","last_name":"Alotaibi"},{"last_name":"Nelson","first_name":"Andrew D.L.","full_name":"Nelson, Andrew D.L."},{"first_name":"Rene","full_name":"Lenobel, Rene","last_name":"Lenobel"},{"full_name":"Friedecká, Jaroslava","first_name":"Jaroslava","last_name":"Friedecká"},{"last_name":"Skirycz","first_name":"Aleksandra","full_name":"Skirycz, Aleksandra"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","full_name":"Friml, Jiří"}],"issue":"19","title":"Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants","abstract":[{"text":"Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved in diverse signaling pathways across both animals and plants. While the role of 3′,5′-cAMP has been extensively characterized, the biological significance of its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling systems in Arabidopsis thaliana, with different enzymatic origins and largely distinct downstream effects. In vitro enzymatic assays show that plant adenylate cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct yet partially overlapping metabolic, proteomic, and transcriptional response: 2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while 3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis. Our findings establish the existence of dual cAMP signaling systems in plants, each with specialized functions and provide insights into the complex regulatory networks governing plant physiology.","lang":"eng"}],"acknowledgement":" We thank J. Chai and D. Yu for providing the MBP-fused L7TIR plasmid and K. Jaworski (Nicolaus Copernicus University) for the GST-HpAC1 plasmid. We also thank M. Randuch and L. Fiedler for providing vectors for recombinant AFB5 and ADCY. We are also grateful to E. Dutkiewicz, L. Trübestein, N. Krasnici and A. Michaelis for excellent technical\r\nassistance. We acknowledge the support of the LSF Mass Spectrometry Service and the Lab\r\nSupport Facility at the Institute of Science and Technology Austria for their contributions,\r\nincluding consultation on size exclusion chromatography, LC/MS experimental design,\r\nmetabolomics sample preparation, LC/MS method optimization, data acquisition, raw data\r\nanalysis, and absolute quantification. This project is supported by the European\r\nResearch Council (ERC) under the European Union’s Horizon 2020 research and innovation\r\nprogram (101142681 CYNIPS) and Austrian Science Fund (FWF; P 37051-B), both to J.Friml.\r\nWe acknowledge the generous support of the Taif University Researchers Supporting\r\nProject: TURSP-HC2022/02 and Max-Planck-Society to A.S. ","publication_status":"published","department":[{"_id":"JiFr"}],"file_date_updated":"2026-06-02T14:33:55Z","publisher":"AAAS","DOAJ_listed":"1","intvolume":" 12","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2026-05-08T00:00:00Z","citation":{"ieee":"M. Li et al., “Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants,” Science Advances, vol. 12, no. 19. AAAS, 2026.","apa":"Li, M., Chodasiewicz, M., Muraleedharan, M., Lopez, I. M., Gorka, M., Kerber, O., … Friml, J. (2026). Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aea7828","ama":"Li M, Chodasiewicz M, Muraleedharan M, et al. Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. 2026;12(19). doi:10.1126/sciadv.aea7828","chicago":"Li, Mingyue, Monika Chodasiewicz, Malavika Muraleedharan, Israel M. Lopez, Michal Gorka, Olga Kerber, Saqer S. Alotaibi, et al. “Biogenesis and Downstream Effects of 3’,5’ and 2’,3’ CAMP Isomers in Plants.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aea7828.","short":"M. Li, M. Chodasiewicz, M. Muraleedharan, I.M. Lopez, M. Gorka, O. Kerber, S.S. Alotaibi, A.D.L. Nelson, R. Lenobel, J. Friedecká, A. Skirycz, J. Friml, Science Advances 12 (2026).","mla":"Li, Mingyue, et al. “Biogenesis and Downstream Effects of 3’,5’ and 2’,3’ CAMP Isomers in Plants.” Science Advances, vol. 12, no. 19, aea7828, AAAS, 2026, doi:10.1126/sciadv.aea7828.","ista":"Li M, Chodasiewicz M, Muraleedharan M, Lopez IM, Gorka M, Kerber O, Alotaibi SS, Nelson ADL, Lenobel R, Friedecká J, Skirycz A, Friml J. 2026. Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. 12(19), aea7828."},"article_number":"aea7828","corr_author":"1","status":"public","type":"journal_article","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","project":[{"_id":"8f347782-16d5-11f0-9cad-8c19706ee739","name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681"},{"grant_number":"P37051","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6"}],"scopus_import":"1","date_updated":"2026-06-02T14:36:41Z","date_created":"2026-05-24T22:01:31Z","quality_controlled":"1","volume":12,"_id":"21914","month":"05","oa_version":"Published Version","doi":"10.1126/sciadv.aea7828"},{"department":[{"_id":"SiHi"}],"citation":{"apa":"Villalba Requena, A., Beattie, R. J., Pauler, F., Streicher, C., Miranda, O., Krausgruber, T., … Hippenmeyer, S. (n.d.). Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously promotes postnatal neuron survival in cell type specific manner. bioRxiv. https://doi.org/10.64898/2026.05.01.722172","ieee":"A. Villalba Requena et al., “Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously promotes postnatal neuron survival in cell type specific manner,” bioRxiv. .","ama":"Villalba Requena A, Beattie RJ, Pauler F, et al. Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously promotes postnatal neuron survival in cell type specific manner. bioRxiv. doi:10.64898/2026.05.01.722172","mla":"Villalba Requena, Ana, et al. “Mtor/Rptor Function Globally Prevents Cortical Microcephaly and Cell-Autonomously Promotes Postnatal Neuron Survival in Cell Type Specific Manner.” BioRxiv, doi:10.64898/2026.05.01.722172.","short":"A. Villalba Requena, R.J. Beattie, F. Pauler, C. Streicher, O. Miranda, T. Krausgruber, M. Senekowitsch, M. Farlik, C. Bock, T. Rülicke, S. Hippenmeyer, BioRxiv (n.d.).","chicago":"Villalba Requena, Ana, Robert J Beattie, Florian Pauler, Carmen Streicher, Osvaldo Miranda, Thomas Krausgruber, Martin Senekowitsch, et al. “Mtor/Rptor Function Globally Prevents Cortical Microcephaly and Cell-Autonomously Promotes Postnatal Neuron Survival in Cell Type Specific Manner.” BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722172.","ista":"Villalba Requena A, Beattie RJ, Pauler F, Streicher C, Miranda O, Krausgruber T, Senekowitsch M, Farlik M, Bock C, Rülicke T, Hippenmeyer S. Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously promotes postnatal neuron survival in cell type specific manner. bioRxiv, 10.64898/2026.05.01.722172."},"date_published":"2026-05-05T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"type":"preprint","date_created":"2026-06-09T08:08:18Z","date_updated":"2026-06-16T08:45:25Z","oa_version":"Preprint","_id":"21962","month":"05","project":[{"_id":"264E56E2-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms Regulating Gliogenesis in the Neocortex","call_identifier":"FWF","grant_number":"M02416"},{"grant_number":"618444","call_identifier":"FP7","name":"Molecular Mechanisms of Cerebral Cortex Development","_id":"25D61E48-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development"}],"main_file_link":[{"url":"https://doi.org/10.64898/2026.05.01.722172","open_access":"1"}],"doi":"10.64898/2026.05.01.722172","publication":"bioRxiv","acknowledged_ssus":[{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"MassSpec"},{"_id":"Bio"}],"language":[{"iso":"eng"}],"year":"2026","OA_place":"repository","oa":1,"article_processing_charge":"No","OA_type":"green","day":"05","ddc":["570"],"author":[{"first_name":"Ana","full_name":"Villalba Requena, Ana","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247","last_name":"Villalba Requena","orcid":"0000-0002-5615-5277"},{"full_name":"Beattie, Robert J","first_name":"Robert J","orcid":"0000-0002-8483-8753","last_name":"Beattie","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Florian","full_name":"Pauler, Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","last_name":"Pauler","orcid":"0000-0002-7462-0048"},{"first_name":"Carmen","full_name":"Streicher, Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Miranda, Osvaldo","first_name":"Osvaldo","id":"862A3C56-A8BF-11E9-B4FA-D9E3E5697425","last_name":"Miranda","orcid":"0000-0001-6618-6889"},{"last_name":"Krausgruber","first_name":"Thomas","full_name":"Krausgruber, Thomas"},{"first_name":"Martin","full_name":"Senekowitsch, Martin","last_name":"Senekowitsch"},{"last_name":"Farlik","full_name":"Farlik, Matthias","first_name":"Matthias"},{"last_name":"Bock","full_name":"Bock, Christoph","first_name":"Christoph"},{"first_name":"Thomas","full_name":"Rülicke, Thomas","last_name":"Rülicke"},{"full_name":"Hippenmeyer, Simon","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061"}],"abstract":[{"text":"The generation of faithful cell-type diversity and correct projection neuron numbers is essential for cerebral cortex development. Corticogenesis is however susceptible to genetic interference of critical signaling pathways, including mutations in Mtor/Rptor that lead to microcephaly. How the loss of Rptor/mTORC1 function affects cortical developmental programs, at single cell level, is still unknown. Here, we utilized Mosaic Analysis with Double Markers (MADM) technology to probe Rptor gene function upon sparse single cell- or global tissue-wide ablation. We found that tissue-wide effects drive the etiology of cortical microcephaly upon loss of Rptor, rather than deficits in projection neuron genesis. Conversely, Rptor function is cell-autonomously required for postnatal projection neuron survival in a highly cell-type-specific manner. Collectively, our results suggest that the fine balance of precise cell-type-specific cell-autonomous Rptor/mTORC1 function in concert with non-cell-autonomous tissue-wide effects is essential for the development of a properly-sized cerebral cortex with accurate projection neuron diversity.","lang":"eng"}],"title":"Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously promotes postnatal neuron survival in cell type specific manner","publication_status":"submitted","acknowledgement":"We thank A. Heger (IST Austria Preclinical Facility), A. Sommer (VBCF GmbH, NGS Unit), and A.\r\nNicolas (IST Austria Lab Support Facility / Mass Spectrometry Facility) for technical support; K. Ferencak,\r\nI. Aykara, P. Hirschfeld, E. Fisher, S. Laukoter, L. Andersen for initial experiments and/or assistance; and\r\nall members of the Hippenmeyer lab for discussion. This research was supported by the Scientific Service\r\nUnits (SSU) of IST Austria through resources provided by the Imaging and Optics- (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF). R.B. received support from FWF Meitner-Programm (M 2416). This\r\nwork was also supported by IST Austria institutional funds; the People Programme (Marie Curie Actions)\r\nof the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement\r\nNo 618444 to S.H., and the European Research Council (ERC) under the European Union’s Horizon 2020\r\nresearch and innovation programme (grant agreement No 725780 LinPro) to S.H."},{"type":"preprint","has_accepted_license":"1","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"project":[{"_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular Mechanisms of Neural Stem Cell Lineage Progression","grant_number":"F7805"},{"grant_number":"725780","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","_id":"260018B0-B435-11E9-9278-68D0E5697425"}],"oa_version":"Preprint","_id":"21963","month":"05","date_created":"2026-06-09T08:08:53Z","date_updated":"2026-06-16T08:57:20Z","doi":"10.64898/2026.05.01.722191","main_file_link":[{"url":"https://doi.org/10.64898/2026.05.01.722191","open_access":"1"}],"department":[{"_id":"SiHi"},{"_id":"PreCl"},{"_id":"GradSch"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Miranda O, Contreras X, Pauler F, Davaatseren A, Amberg N, Streicher C, Villalba Requena A, Heger A-M, Marie C, Hassan BA, Rülicke T, Hippenmeyer S. Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical astrocyte production. bioRxiv, 10.64898/2026.05.01.722191.","chicago":"Miranda, Osvaldo, Ximena Contreras, Florian Pauler, Amarbayasgalan Davaatseren, Nicole Amberg, Carmen Streicher, Ana Villalba Requena, et al. “Pten Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production.” BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722191.","short":"O. Miranda, X. Contreras, F. Pauler, A. Davaatseren, N. Amberg, C. Streicher, A. Villalba Requena, A.-M. Heger, C. Marie, B.A. Hassan, T. Rülicke, S. Hippenmeyer, BioRxiv (n.d.).","mla":"Miranda, Osvaldo, et al. “Pten Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production.” BioRxiv, doi:10.64898/2026.05.01.722191.","ama":"Miranda O, Contreras X, Pauler F, et al. Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical astrocyte production. bioRxiv. doi:10.64898/2026.05.01.722191","ieee":"O. Miranda et al., “Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical astrocyte production,” bioRxiv. .","apa":"Miranda, O., Contreras, X., Pauler, F., Davaatseren, A., Amberg, N., Streicher, C., … Hippenmeyer, S. (n.d.). Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical astrocyte production. bioRxiv. https://doi.org/10.64898/2026.05.01.722191"},"date_published":"2026-05-05T00:00:00Z","status":"public","corr_author":"1","ec_funded":1,"OA_type":"green","article_processing_charge":"No","oa":1,"OA_place":"repository","author":[{"full_name":"Miranda, Osvaldo","first_name":"Osvaldo","orcid":"0000-0001-6618-6889","last_name":"Miranda","id":"862A3C56-A8BF-11E9-B4FA-D9E3E5697425"},{"first_name":"Ximena","full_name":"Contreras, Ximena","last_name":"Contreras","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Florian","full_name":"Pauler, Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","last_name":"Pauler","orcid":"0000-0002-7462-0048"},{"last_name":"Davaatseren","id":"70ADC922-B424-11E9-99E3-BA18E6697425","full_name":"Davaatseren, Amarbayasgalan","first_name":"Amarbayasgalan"},{"orcid":"0000-0002-3183-8207","last_name":"Amberg","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","full_name":"Amberg, Nicole"},{"first_name":"Carmen","full_name":"Streicher, Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-5615-5277","id":"68cb85a0-39f7-11eb-9559-9aaab4f6a247","last_name":"Villalba Requena","first_name":"Ana","full_name":"Villalba Requena, Ana"},{"last_name":"Heger","id":"4B76FFD2-F248-11E8-B48F-1D18A9856A87","first_name":"Anna-Magdalena","full_name":"Heger, Anna-Magdalena"},{"first_name":"Corentine","full_name":"Marie, Corentine","last_name":"Marie"},{"full_name":"Hassan, Bassem A.","first_name":"Bassem A.","last_name":"Hassan"},{"last_name":"Rülicke","full_name":"Rülicke, Thomas","first_name":"Thomas"},{"first_name":"Simon","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061"}],"ddc":["570"],"day":"05","title":"Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical astrocyte production","abstract":[{"lang":"eng","text":"The cerebral cortex consists of immense numbers of neuronal and glial cell-types derived from radial glial progenitor (RGP) cells. How RGPs generate appropriate quantities of distinct cortical cell-types to safeguard a brain of correct size, is not well understood. However, genetic aberration in human, including mutations in PTEN, lead to cortical malformation such as macrocephaly, albeit with unknown etiology. Here we utilized Mosaic Analysis with Double Markers (MADM)-based clonal analysis and single cell phenotyping to decipher the role of Pten in neurogenic and gliogenic RGP lineage progression during cortical ontogeny. While neurogenic RGP lineage progression and projection neuron production was moderately altered in the absence of Pten, cortical astrocyte production was drastically increased. Through genetic epistasis experiments we show that the loss of Pten uncouples astrocyte generation from essential growth factor signaling hubs, funneling into MAPK. Collectively, our results suggest that Pten regulates RGP lineage progression with distinct sequential functions in cortical projection neurogenesis and astrocyte production to ensure the emergence of a correctly-sized cerebral cortex."}],"acknowledgement":"We thank Kay-Uwe Wagner (Wayne State University) for generously sharing Jak1/2–flox mouse lines; A.\r\nSommer (VBCF GmbH, NGS Unit) for technical support; N. Kim, V. Mick, S. Schnabl, S. Gobeil, and L.\r\nAndersen for technical assistance; all members of the Hippenmeyer lab for discussion and B. Novitch for\r\ncomments on earlier versions of the manuscript. This research was supported by the Scientific Service Units\r\n(SSU) of IST Austria through resources provided by the Imaging and Optics Facility (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF). O.A.M received support from the Austrian Academy of Sciences\r\nÖAW (DOC 186584), and N.A. from FWF Elise Richter Program (Grant V1041T). This work was also\r\nsupported by IST Austria institutional funds; FWF SFB F78 (Neuro Stem Modulation) to S.H., and the\r\nEuropean Research Council (ERC) under the European Union’s Horizon 2020 research and innovation\r\nprogramme (grant agreement No 725780 LinPro) to S.H.","publication_status":"submitted","publication":"bioRxiv","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"language":[{"iso":"eng"}],"year":"2026"},{"related_material":{"record":[{"id":"20641","relation":"earlier_version","status":"public"},{"relation":"used_in_publication","id":"22105","status":"public"}]},"type":"research_data","has_accepted_license":"1","tmp":{"image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","short":"CC BY-NC (4.0)"},"doi":"10.15479/AT-ISTA-21145","contributor":[{"first_name":"Haohao","contributor_type":"researcher","last_name":"Fu"},{"contributor_type":"researcher","first_name":"Benjamin","id":"71cda2f3-e604-11ee-a1df-da10587eda3f","last_name":"Tatman"},{"first_name":"Matthias","contributor_type":"researcher","last_name":"Dreydoppel"},{"last_name":"Kapitonova","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","first_name":"Anna","contributor_type":"researcher"},{"first_name":"Daniel","contributor_type":"researcher","last_name":"Balazs","id":"302BADF6-85FC-11EA-9E3B-B9493DDC885E","orcid":"0000-0001-7597-043X"},{"first_name":"Ulrich","contributor_type":"researcher","last_name":"Weininger"},{"last_name":"Engilberge","first_name":"Sylvain","contributor_type":"researcher"}],"project":[{"_id":"7be609c4-9f16-11ee-852c-85015ce2b9b0","name":"Exploring protein dynamics by solid-state MAS NMR through specific labeling approaches","grant_number":"26777"}],"date_updated":"2026-06-24T08:47:57Z","date_created":"2026-02-05T13:54:39Z","oa_version":"Published Version","_id":"21145","month":"02","publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"PaSc"}],"file_date_updated":"2026-02-05T13:52:41Z","corr_author":"1","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Becker, Lea Marie, Paul Schanda, and Christophe Chipot. “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21145.","short":"L.M. Becker, P. Schanda, C. Chipot, (2026).","mla":"Becker, Lea Marie, et al. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21145.","ista":"Becker LM, Schanda P, Chipot C. 2026. Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes’, Institute of Science and Technology Austria, 10.15479/AT-ISTA-21145.","ieee":"L. M. Becker, P. Schanda, and C. Chipot, “Additional Data for ‘Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.’” Institute of Science and Technology Austria, 2026.","apa":"Becker, L. M., Schanda, P., & Chipot, C. (2026). Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21145","ama":"Becker LM, Schanda P, Chipot C. Additional Data for “Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes.” 2026. doi:10.15479/AT-ISTA-21145"},"date_published":"2026-02-09T00:00:00Z","day":"09","ddc":["572"],"author":[{"id":"36336939-eb97-11eb-a6c2-c83f1214ca79","last_name":"Becker","orcid":"0000-0002-6401-5151","first_name":"Lea Marie","full_name":"Becker, Lea Marie"},{"first_name":"Paul","full_name":"Schanda, Paul","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","last_name":"Schanda","orcid":"0000-0002-9350-7606"},{"first_name":"Christophe","full_name":"Chipot, Christophe","last_name":"Chipot"}],"article_processing_charge":"No","oa":1,"acknowledgement":"We thank Nikolai R. Skrynnikov and Olga O. Lebedenko (St. Petersburg) for insightful discussions and for performing exploratory MD simulations. We are grateful to Tobias Schubeis (Lyon) for advice with GB1 crystallization, and Rebecca Schmid for initial crystallization trials.\r\nWe thank Sebastian Falkner for assistance with constructing the structural model of the IgG:GB1 complex.\r\nThis research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra Rovó and Margarita Valhondo Falcón for excellent support of the NMR facility.\r\nLea M. Becker is recipient of a DOC fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology Austria (grant no. PR10660EAW01). Christophe Chipot acknowledges the European Research Council (grant project 101097272 ``MilliInMicro'') and the Métropole du Grand Nancy (grant project ``ARC''). BM07-FIP2 is supported by the French ANR PIA3 (France 2030) EquipEx+ project MAGNIFIX under grant agreement ANR-21-ESRE-0011.","title":"Additional Data for \"Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes\"","abstract":[{"text":"Protein conformational energy landscapes are shaped not only by intramolecular interactions but also by their environment. In protein crystals and protein-protein complexes, intermolecular contacts alter this energy landscape, but the exact nature of this alteration is difficult to decipher. Understanding how the crystal lattice affects protein dynamics is crucial for crystallography-based studies of motion, yet its influence on collective motions remains unclear. Aromatic ring flips in the hydrophobic core represent sensitive probes of such dynamics. Here, we compare the kinetics of aromatic ring flips in the protein GB1 in crystals, in complex with its binding partner IgG, and in solution, combining advanced isotope labeling with quantitative NMR methods. We show that rings in the core flip nearly a thousand times less frequently in crystals than in solution. Enhanced-sampling molecular dynamics simulations, based on a new crystal structure, reproduce these elevated barriers and reveal how the crystal restrains motions. ","lang":"eng"}],"acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"file":[{"file_name":"README.txt","file_id":"21146","relation":"table_of_contents","checksum":"02a419cce8cea450bc952f35488d2df5","creator":"lbecker","file_size":4263,"date_updated":"2026-02-05T13:52:37Z","date_created":"2026-02-05T13:52:37Z","content_type":"text/plain","access_level":"open_access"},{"file_name":"Research_Data.zip","relation":"main_file","file_id":"21147","checksum":"b0b82b1aa73985b0b308a3fa52d21aea","creator":"lbecker","success":1,"date_updated":"2026-02-05T13:52:41Z","date_created":"2026-02-05T13:52:41Z","file_size":50647107,"access_level":"open_access","content_type":"application/zip"}],"year":"2026"},{"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication":"Nature","year":"2026","article_type":"original","researchdata_availability":"yes","dataavailabilitystatement":"Single-nucleus multiomics data are available from the Gene Expression Omnibus (GSE328363). The mm10 reference genome was used for the alignment (refdata-cellranger-arc-mm10-2020-A-2.0.0, obtained from https://cf.10xgenomics.com/supp/cell-arc/refdata-cellranger-arc-mm10-2020-A-2.0.0.tar.gz). Single-cell data can be accessed and visualized through a CELLxGENE database (https://adameykolab.hifo.meduniwien.ac.at/cellxgene_public/filecrawl/.2026_Nature_Schwarz). Source data are provided with this paper. Scripts and analyses that support the main findings of this study are accessible in a GitHub repository (https://git.ista.ac.at/research-sofware/mouseome).","pmid":1,"external_id":{"pmid":["42310454"]},"language":[{"iso":"eng"}],"author":[{"last_name":"Schwarz","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","first_name":"Lena A","full_name":"Schwarz, Lena A"},{"orcid":"0000-0002-9033-9096","last_name":"Dotter","id":"4C66542E-F248-11E8-B48F-1D18A9856A87","full_name":"Dotter, Christoph","first_name":"Christoph"},{"full_name":"Isaev, Sergey","first_name":"Sergey","last_name":"Isaev"},{"last_name":"Lisi","id":"39383c1b-d3eb-11ef-8d6c-c8cdf4e10c8c","first_name":"Michela","full_name":"Lisi, Michela"},{"last_name":"Malzl","first_name":"Daniel","full_name":"Malzl, Daniel"},{"last_name":"Büschl","id":"2a8c054c-0913-11ee-9159-f8ef515809ed","first_name":"Christoph","full_name":"Büschl, Christoph"},{"last_name":"Ladstätter","full_name":"Ladstätter, Sabrina","first_name":"Sabrina"},{"last_name":"Oliveira","id":"3B03AA1A-F248-11E8-B48F-1D18A9856A87","full_name":"Oliveira, Bárbara","first_name":"Bárbara"},{"last_name":"Barel","id":"8959927b-2236-11ed-bd6e-ea83d94ade0e","first_name":"Matteo","full_name":"Barel, Matteo"},{"id":"36035796-5ACA-11E9-A75E-7AF2E5697425","last_name":"Basilico","orcid":"0000-0003-1843-3173","first_name":"Bernadette","full_name":"Basilico, Bernadette"},{"first_name":"Chaitanya","full_name":"Chintaluri, Chaitanya","orcid":"0000-0003-4252-1608","last_name":"Chintaluri","id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E"},{"id":"f141a35d-15a9-11ec-9fb2-fef6becc7b6f","last_name":"Gorkiewicz","first_name":"Sarah","full_name":"Gorkiewicz, Sarah"},{"last_name":"Goudarzi","id":"3384113A-F248-11E8-B48F-1D18A9856A87","first_name":"Mohammad","full_name":"Goudarzi, Mohammad"},{"first_name":"Tereza","full_name":"Belinova, Tereza","last_name":"Belinova","id":"0bf89b6a-d28b-11eb-8bd6-f43768e4d368"},{"first_name":"Stephan","full_name":"Reichl, Stephan","last_name":"Reichl"},{"id":"dd6d52f2-c50d-11eb-9548-bcf0ff82b344","last_name":"Sendžikaitė","first_name":"Gintarė","full_name":"Sendžikaitė, Gintarė"},{"full_name":"Arcot Jayaram, Satish","first_name":"Satish","id":"b0bbee33-09f7-11eb-909c-8b358058d28a","last_name":"Arcot Jayaram","orcid":"0000-0002-2479-2669"},{"last_name":"Koppensteiner","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter","first_name":"Peter"},{"full_name":"Sommer, Christoph M","first_name":"Christoph M","last_name":"Sommer","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","first_name":"Tim P"},{"first_name":"Jörg","full_name":"Menche, Jörg","last_name":"Menche"},{"first_name":"Igor","full_name":"Adameyko, Igor","last_name":"Adameyko"},{"first_name":"Peter Vasili","full_name":"Kharchenko, Peter Vasili","id":"0095641e-7eb7-11f1-8665-aec51a2ab5e0","last_name":"Kharchenko"},{"full_name":"Bock, Christoph","first_name":"Christoph","last_name":"Bock"},{"first_name":"Gaia","full_name":"Novarino, Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178"}],"day":"17","ddc":["570"],"oa":1,"OA_place":"publisher","OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","publication_status":"epub_ahead","acknowledgement":"We thank F. Freeman, V. Voronin and M. Ladron de Guevara for technical assistance; A. Stichelberger and S. Liegenfeld for the management of our animal colony; M. Schunn, C. Gold and the Preclinical Facility team for technical assistance; C. Jansen and the Scientific Computing Facility for bioinformatics support and technical assistance; the Biomedical Sequencing Facility at CeMM for assistance with next-generation sequencing; and J. Lin and T. Krausgruber in the laboratory of C. Bock for support with flow cytometry; J. Kirchner for illustrating the multi-omics approach depicted in Fig. 1; and all members of the laboratory of G.N. for their support and discussions. This study was supported by the Scientific Service Units of ISTA through resources provided by the Imaging & Optics Facility and the Laboratory Support Facility. Bulk RNA-seq was performed by the Next Generation Sequencing Facility at Vienna BioCenter Core Facilities, member of the Vienna BioCenter. This work was supported by a European Research Council Consolidator Grant (PR1028ERC02), by SFARI (PR1028SIM02) and by the Austrian Science Fund (PE1028W1232 and PR1028FG1803) to G.N. Open access funding provided by Institute of Science and Technology (IST Austria).","abstract":[{"lang":"eng","text":"Despite the functional diversity of over 100 causal genes1,2,3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences emerged in neurons at early postnatal stages. These changes included downregulation of synaptic and ion channel-related genes, consistent with homeostatic adaptation or delayed maturation. Network analysis showed molecular convergence across models within each developmental stage, suggesting that diverse mutations linked to ASD impinge on common, stage-specific processes. Convergence becomes less pronounced by postnatal day 14, highlighting the dynamic nature of ASD-associated changes. Cross-genotype heterogeneity is superimposed on stage-specific effects. Electrophysiology corroborated this pattern: mutants generally showed altered neuronal excitability and synaptic properties with model-specific nuances. Our study also highlighted sex-specific gene expression alterations, with female mice often displaying larger effect sizes than male mice. Together, our findings provide a comprehensive view of developmental cellular and molecular dynamics across models of ASD."}],"title":"Cortical development dynamics across autism spectrum disorder mouse models","publisher":"Springer Nature","department":[{"_id":"AnKi"},{"_id":"GaNo"},{"_id":"TiVo"},{"_id":"ScienComp"},{"_id":"GradSch"},{"_id":"Bio"},{"_id":"PreCl"}],"corr_author":"1","status":"public","citation":{"mla":"Schwarz, Lena A., et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature, Springer Nature, 2026, doi:10.1038/s41586-026-10679-1.","short":"L.A. Schwarz, C. Dotter, S. Isaev, M. Lisi, D. Malzl, C. Büschl, S. Ladstätter, B. Oliveira, M. Barel, B. Basilico, C. Chintaluri, S. Gorkiewicz, M. Goudarzi, T. Belinova, S. Reichl, G. Sendžikaitė, S. Arcot Jayaram, P. Koppensteiner, C.M. Sommer, T.P. Vogels, J. Menche, I. Adameyko, P.V. Kharchenko, C. Bock, G. Novarino, Nature (2026).","chicago":"Schwarz, Lena A, Christoph Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, et al. “Cortical Development Dynamics across Autism Spectrum Disorder Mouse Models.” Nature. Springer Nature, 2026. https://doi.org/10.1038/s41586-026-10679-1.","ista":"Schwarz LA, Dotter C, Isaev S, Lisi M, Malzl D, Büschl C, Ladstätter S, Oliveira B, Barel M, Basilico B, Chintaluri C, Gorkiewicz S, Goudarzi M, Belinova T, Reichl S, Sendžikaitė G, Arcot Jayaram S, Koppensteiner P, Sommer CM, Vogels TP, Menche J, Adameyko I, Kharchenko PV, Bock C, Novarino G. 2026. Cortical development dynamics across autism spectrum disorder mouse models. Nature.","apa":"Schwarz, L. A., Dotter, C., Isaev, S., Lisi, M., Malzl, D., Büschl, C., … Novarino, G. (2026). Cortical development dynamics across autism spectrum disorder mouse models. Nature. Springer Nature. https://doi.org/10.1038/s41586-026-10679-1","ieee":"L. A. Schwarz et al., “Cortical development dynamics across autism spectrum disorder mouse models,” Nature. Springer Nature, 2026.","ama":"Schwarz LA, Dotter C, Isaev S, et al. Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026. doi:10.1038/s41586-026-10679-1"},"date_published":"2026-06-17T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","supplementarymaterial":"yes","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","has_accepted_license":"1","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1038/s41586-026-10679-1","open_access":"1"}],"doi":"10.1038/s41586-026-10679-1","oa_version":"Published Version","_id":"22295","month":"06","date_updated":"2026-07-13T12:58:19Z","date_created":"2026-07-13T09:47:21Z","quality_controlled":"1","scopus_import":"1","project":[{"grant_number":"101044865","_id":"34ba8964-11ca-11ed-8bc3-e15864e7e9a6","name":"Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders"},{"grant_number":"707964","name":"Critical windows and reversibility of ASD associated with mutations in chromatin remodelers","_id":"9B91375C-BA93-11EA-9121-9846C619BF3A"},{"_id":"2548AE96-B435-11E9-9278-68D0E5697425","name":"Molecular Drug Targets","call_identifier":"FWF","grant_number":"W1232"},{"grant_number":"FG1803 49015","_id":"ebb38b5d-77a9-11ec-83b8-a42e08120a88","name":"Neurobiology of anxiety in autism spectrum disorders"}]}]