---
OA_place: publisher
_id: '20964'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Master’s Thesis
article_processing_charge: No
author:
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
citation:
ama: Vladimirtsev D. Armadillo repeat only proteins are master regulators of plant
cyclic-nucleotide gated channels. 2026. doi:10.15479/AT-ISTA-20964
apa: Vladimirtsev, D. (2026). Armadillo repeat only proteins are master regulators
of plant cyclic-nucleotide gated channels. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT-ISTA-20964
chicago: Vladimirtsev, Dmitrii. “Armadillo Repeat Only Proteins Are Master Regulators
of Plant Cyclic-Nucleotide Gated Channels.” Institute of Science and Technology
Austria, 2026. https://doi.org/10.15479/AT-ISTA-20964.
ieee: D. Vladimirtsev, “Armadillo repeat only proteins are master regulators of
plant cyclic-nucleotide gated channels,” Institute of Science and Technology Austria,
2026.
ista: Vladimirtsev D. 2026. Armadillo repeat only proteins are master regulators
of plant cyclic-nucleotide gated channels. Institute of Science and Technology
Austria.
mla: Vladimirtsev, Dmitrii. Armadillo Repeat Only Proteins Are Master Regulators
of Plant Cyclic-Nucleotide Gated Channels. Institute of Science and Technology
Austria, 2026, doi:10.15479/AT-ISTA-20964.
short: D. Vladimirtsev, Armadillo Repeat Only Proteins Are Master Regulators of
Plant Cyclic-Nucleotide Gated Channels, Institute of Science and Technology Austria,
2026.
corr_author: '1'
date_created: 2026-01-09T09:22:48Z
date_published: 2026-01-14T00:00:00Z
date_updated: 2026-04-07T11:41:44Z
day: '14'
ddc:
- '570'
degree_awarded: MS
department:
- _id: GradSch
- _id: JiFr
doi: 10.15479/AT-ISTA-20964
file:
- access_level: closed
checksum: 812857b2fbe3f6113bef22fd04bccd3e
content_type: application/pdf
creator: dvladimi
date_created: 2026-01-21T14:12:13Z
date_updated: 2026-01-21T14:12:13Z
embargo: 2027-01-01
embargo_to: open_access
file_id: '21033'
file_name: 2026_Vladimirtsev_Dmitrii_Thesis.pdf
file_size: 2867531
relation: main_file
- access_level: closed
checksum: 2b969f97f8d7461bea3d255f48c2219c
content_type: application/x-zip-compressed
creator: dvladimi
date_created: 2026-01-21T14:41:58Z
date_updated: 2026-01-28T12:38:19Z
file_id: '21034'
file_name: Source Files.zip
file_size: 25023066
relation: source_file
file_date_updated: 2026-01-28T12:38:19Z
fulldoi: https://doi.org/10.15479/AT-ISTA-20964
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa_version: Published Version
page: '22'
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '20982'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
title: Armadillo repeat only proteins are master regulators of plant cyclic-nucleotide
gated channels
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21015'
abstract:
- lang: eng
text: Early embryo geometry is one of the most invariant species-specific traits,
yet its role in ensuring developmental reproducibility and robustness remains
underexplored. Here we show that in zebrafish, the geometry of the fertilized
egg—specifically its curvature and volume—serves as a critical initial condition
triggering a cascade of events that influence development. The embryo geometry
guides patterned asymmetric cell divisions in the blastoderm, generating radial
gradients of cell volume and nucleocytoplasmic ratio. These gradients generate
mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell
cycle periods independently of other cells. We demonstrate that reducing cell
autonomy reshapes these waves, emphasizing the instructive role of geometry-derived
volume patterns in setting the intrinsic period of the cell cycle oscillator.
In addition to organizing cell cycles, early embryo geometry spatially patterns
zygotic genome activation at the midblastula transition, a key step in establishing
embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation
pattern and causes ectopic germ layer specification, underscoring the developmental
significance of geometry. Together, our findings reveal a symmetry-breaking function
of early embryo geometry in coordinating cell cycle and transcriptional patterning.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: ScienComp
- _id: LifeSc
acknowledgement: We thank N. Petridou (EMBL) for sharing results before publication.
N.M. was supported by funding from the European Union’s Horizon 2020 programme under
the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411.
Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413.
The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project
ID 1.844. We would like to thank past and present members of the Heisenberg and
Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic,
N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript.
This research was supported by the Scientific Service Units (SSU) of Institute of
Science and Technology Austria through resources provided by the Aquatics Facility,
Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab
Support Facility (LSF). Open access funding provided by Institute of Science and
Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nikhil
full_name: Mishra, Nikhil
id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
last_name: Mishra
orcid: 0000-0002-6425-5788
- first_name: Yuting I
full_name: Li, Yuting I
id: ee7a5ca8-8b71-11ed-b662-b3341c05b7eb
last_name: Li
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell
divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo.
Nature Physics. 2026;22:139-150. doi:10.1038/s41567-025-03122-1
apa: Mishra, N., Li, Y. I., Hannezo, E. B., & Heisenberg, C.-P. J. (2026). Geometry-driven
asymmetric cell divisions pattern cell cycles and zygotic genome activation in
the zebrafish embryo. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03122-1
chicago: Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg.
“Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome
Activation in the Zebrafish Embryo.” Nature Physics. Springer Nature, 2026.
https://doi.org/10.1038/s41567-025-03122-1.
ieee: N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven
asymmetric cell divisions pattern cell cycles and zygotic genome activation in
the zebrafish embryo,” Nature Physics, vol. 22. Springer Nature, pp. 139–150,
2026.
ista: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric
cell divisions pattern cell cycles and zygotic genome activation in the zebrafish
embryo. Nature Physics. 22, 139–150.
mla: Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell
Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics,
vol. 22, Springer Nature, 2026, pp. 139–50, doi:10.1038/s41567-025-03122-1.
short: N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026)
139–150.
corr_author: '1'
date_created: 2026-01-20T10:12:19Z
date_published: 2026-01-05T00:00:00Z
date_updated: 2026-04-28T12:55:30Z
day: '05'
ddc:
- '570'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1038/s41567-025-03122-1
ec_funded: 1
external_id:
oaworkid:
- W7118187193
file:
- access_level: open_access
checksum: 0ab7ac2fbcb61a364dba57152db64ed7
content_type: application/pdf
creator: dernst
date_created: 2026-01-21T08:21:11Z
date_updated: 2026-01-21T08:21:11Z
file_id: '21026'
file_name: 2026_NaturePhysics_Mishra.pdf
file_size: 7335694
relation: main_file
success: 1
file_date_updated: 2026-01-21T08:21:11Z
fulldoi: https://doi.org/10.1038/s41567-025-03122-1
has_accepted_license: '1'
intvolume: ' 22'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
oaworkid: 1
page: 139-150
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: 917c023a-16d5-11f0-9cad-eb5cafc52090
name: Cytoplasmic self-organization into cell-like compartments as a common guiding
principle in early animal development
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
issnl:
- ' 1745-2473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: research_data
url: https://ista.ac.at/en/news/geometry-shapes-life/
scopus_import: '1'
status: public
title: Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome
activation in the zebrafish embryo
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 22
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21040'
abstract:
- lang: eng
text: Formation during the first cycles of Li-rich layered oxide (LRLO) cathode
materials consolidates the interphase and leads to structural changes that are
decisive for long-term cyclability. However, the nature and effect of the changes
are material-dependent and unknown for the important class of Co-free, Ni-poor
LRLOs. Here, we analyze the processes during the tailored formation procedure
of a typical class member, Li1.28Ni0.15Mn0.57O2, and demonstrate that it remarkably
changes lattice composition and structure as a prerequisite for stable cycling.
We combine electrochemistry, operando mass spectrometry, X-ray diffraction, and
X-ray absorption spectroscopy with density functional theory simulations. Activation
most prominently compresses the layer spacing along the c-axis and increases reversible
structural breathing. The large capacity of ∼250 mAh g–1 originates from the Ni2+/Ni4+
and O2–/O– redox couples. Electron exchange during O-redox is smeared over the
entire anionic sublattice rather than localized on specific oxygen atomic sites.
This redox mechanism is reversible without detrimental oxygen evolution, avoiding
continued degradation common in conventional LRLOs. Sequential Ni- and O-redox
during activation irreversibly distorts the coordination of the redox-inactive
Mn4+ centers. This structural evolution of the MnO6 octahedra appears to enable
the superior electrochemical performance of this LRLO phase. These findings define
an activation pathway for the important class of Co-free, Ni-poor LRLOs, offering
potential guidance for the rational design of high-performance, more sustainable
cathode materials.
acknowledged_ssus:
- _id: M-Shop
- _id: LifeSc
acknowledgement: 'Elettra-Sincrotrone Trieste S.C.p.A. and its staff are acknowledged
for providing synchrotron radiation beamtime and laboratory facilities, in particular
the MCX and XAFS beamlines, where the XRD and XAS experiments have been carried
out, supported by the projects number: 20217082, 20205109, and 20195014. This study
was carried out within the MOST─Sustainable Mobility Center and received funding
from the European Union Next-Generation EU (PIANO NAZIONALE DI RIPRESA E RESILIENZA
(PNRR)─MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.4─D.D. 1033 17/06/2022, CN00000023).
Moreover, the contribution of S.B. and A.C. to this study was carried out within
the NEST─Network for Energy Sustainable Transition and received funding from the
European Union Next-Generation EU (PNRR─MISSIONE 4 COMPONENTE 2, INVESTIMENTO 1.3─D.D.
1561 11/10/2022, B53C22004070006). This manuscript reflects only the authors’ views
and opinions, neither the European Union nor the European Commission can be considered
responsible for them. Two of us, S.B. and S.A.F., would like to thank the Alistore
ERI. L.S. received funds from the Ministry of Ecological Transition in the “Ricerca
di Sistema Elettrico” framework. S.A.F. is indebted to ISTA for support. The Scientific
Service Units of ISTA supported this research through resources provided by the
Lab Support Facility and the Miba Machine Shop.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Matteo
full_name: Busato, Matteo
last_name: Busato
- first_name: Mariarosaria
full_name: Tuccillo, Mariarosaria
last_name: Tuccillo
- first_name: Arcangelo
full_name: Celeste, Arcangelo
last_name: Celeste
- first_name: Alessandro
full_name: Tofoni, Alessandro
last_name: Tofoni
- first_name: Laura
full_name: Silvestri, Laura
last_name: Silvestri
- first_name: Paola
full_name: D’Angelo, Paola
last_name: D’Angelo
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Sergio
full_name: Brutti, Sergio
last_name: Brutti
citation:
ama: Busato M, Tuccillo M, Celeste A, et al. Structural rearrangements of a Cobalt-free
Lithium-rich layered oxide cathode during formation. ACS Applied Energy Materials.
2026;9(1):686-697. doi:10.1021/acsaem.5c03511
apa: Busato, M., Tuccillo, M., Celeste, A., Tofoni, A., Silvestri, L., D’Angelo,
P., … Brutti, S. (2026). Structural rearrangements of a Cobalt-free Lithium-rich
layered oxide cathode during formation. ACS Applied Energy Materials. American
Chemical Society. https://doi.org/10.1021/acsaem.5c03511
chicago: Busato, Matteo, Mariarosaria Tuccillo, Arcangelo Celeste, Alessandro Tofoni,
Laura Silvestri, Paola D’Angelo, Stefan Alexander Freunberger, and Sergio Brutti.
“Structural Rearrangements of a Cobalt-Free Lithium-Rich Layered Oxide Cathode
during Formation.” ACS Applied Energy Materials. American Chemical Society,
2026. https://doi.org/10.1021/acsaem.5c03511.
ieee: M. Busato et al., “Structural rearrangements of a Cobalt-free Lithium-rich
layered oxide cathode during formation,” ACS Applied Energy Materials,
vol. 9, no. 1. American Chemical Society, pp. 686–697, 2026.
ista: Busato M, Tuccillo M, Celeste A, Tofoni A, Silvestri L, D’Angelo P, Freunberger
SA, Brutti S. 2026. Structural rearrangements of a Cobalt-free Lithium-rich layered
oxide cathode during formation. ACS Applied Energy Materials. 9(1), 686–697.
mla: Busato, Matteo, et al. “Structural Rearrangements of a Cobalt-Free Lithium-Rich
Layered Oxide Cathode during Formation.” ACS Applied Energy Materials,
vol. 9, no. 1, American Chemical Society, 2026, pp. 686–97, doi:10.1021/acsaem.5c03511.
short: M. Busato, M. Tuccillo, A. Celeste, A. Tofoni, L. Silvestri, P. D’Angelo,
S.A. Freunberger, S. Brutti, ACS Applied Energy Materials 9 (2026) 686–697.
corr_author: '1'
date_created: 2026-01-25T23:01:40Z
date_published: 2026-01-12T00:00:00Z
date_updated: 2026-02-12T14:04:04Z
day: '12'
ddc:
- '540'
department:
- _id: StFr
doi: 10.1021/acsaem.5c03511
file:
- access_level: open_access
checksum: 81272c19df41c696c1737168d3ea8c16
content_type: application/pdf
creator: dernst
date_created: 2026-02-12T13:55:28Z
date_updated: 2026-02-12T13:55:28Z
file_id: '21222'
file_name: 2026_AppliedEnergyMaterials_Busato.pdf
file_size: 5977526
relation: main_file
success: 1
file_date_updated: 2026-02-12T13:55:28Z
fulldoi: https://doi.org/10.1021/acsaem.5c03511
has_accepted_license: '1'
intvolume: ' 9'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 686-697
publication: ACS Applied Energy Materials
publication_identifier:
eissn:
- 2574-0962
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural rearrangements of a Cobalt-free Lithium-rich layered oxide cathode
during formation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2026'
...
---
OA_place: repository
_id: '21137'
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: ScienComp
- _id: LifeSc
acknowledgement: We thank all members of the Heisenberg, Henkes, and Hannezo groups
for their support. We are also grateful to the Imaging and Optics, Scientific Computing,
Life Science Support, and Cryo-Electron Microscopy facilities at ISTA for their
technical assistance and support. Numerical simulations were performed using the
computational resources from Lorentz Institute and the Academic Leiden Interdisciplinary
Cluster Environment (ALICE) provided by Leiden University, and from PMMH provided
by Sorbonne Université. S.N has received funding from European Union’s Horizon 2020
research and innovation programme (grant agreement No. 665385). This work was supported
by the Austrian Science Fund (FWF) under projects PAT5044023 and W1250 awarded to
C.-P.H.
article_processing_charge: No
author:
- first_name: Suyash
full_name: Naik, Suyash
id: 2C0B105C-F248-11E8-B48F-1D18A9856A87
last_name: Naik
orcid: 0000-0001-8421-5508
citation:
ama: Naik S. Data associated with Keratins coordinate tissue spreading . 2026. doi:10.15479/AT-ISTA-21137
apa: Naik, S. (2026). Data associated with Keratins coordinate tissue spreading
. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21137
chicago: Naik, Suyash. “Data Associated with Keratins Coordinate Tissue Spreading
.” Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21137.
ieee: S. Naik, “Data associated with Keratins coordinate tissue spreading .” Institute
of Science and Technology Austria, 2026.
ista: Naik S. 2026. Data associated with Keratins coordinate tissue spreading ,
Institute of Science and Technology Austria, 10.15479/AT-ISTA-21137.
mla: Naik, Suyash. Data Associated with Keratins Coordinate Tissue Spreading
. Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21137.
short: S. Naik, (2026).
contributor:
- contributor_type: researcher
first_name: Yann-Edwin
last_name: Keta
- contributor_type: supervisor
first_name: 'Silke '
last_name: Henkes
- contributor_type: supervisor
first_name: Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- contributor_type: supervisor
first_name: Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
corr_author: '1'
date_created: 2026-02-04T16:38:02Z
date_published: 2026-03-24T00:00:00Z
date_updated: 2026-06-10T09:44:10Z
day: '24'
department:
- _id: GradSch
- _id: CaHe
- _id: EdHa
doi: 10.15479/AT-ISTA-21137
ec_funded: 1
file:
- access_level: open_access
checksum: 5d1fda7e410f24c311fcf6bcf725698f
content_type: application/zip
creator: snaik
date_created: 2026-03-16T11:51:10Z
date_updated: 2026-03-16T11:51:10Z
description: 'Python3 library written in C++20 to integrate vertex models. Please
read the readme at https://github.com/yketa/cells/blob/main/README.md for detailed
instructions for installation and usage of the code in this repository. '
file_id: '21461'
file_name: cells-main.zip
file_size: 725916
relation: main_file
title: Cell git repository
- access_level: open_access
checksum: ee350c8eaed99f3ca348c47c8b190d3c
content_type: application/x-zip-compressed
creator: snaik
date_created: 2026-03-18T14:52:02Z
date_updated: 2026-03-18T14:52:02Z
file_id: '21464'
file_name: DevBranchDataRepo.zip
file_size: 282168895
relation: main_file
success: 1
- access_level: open_access
checksum: 1ecaf2c1a2ce8ff9c75a128cc02d0b8f
content_type: text/markdown
creator: snaik
date_created: 2026-03-18T15:01:32Z
date_updated: 2026-03-18T15:01:32Z
file_id: '21466'
file_name: ReadMe.md
file_size: 2231
relation: main_file
success: 1
- access_level: open_access
checksum: da9a4687e5144b61a64ca341f922046a
content_type: image/svg+xml
creator: snaik
date_created: 2026-03-18T15:12:57Z
date_updated: 2026-03-18T15:12:57Z
file_id: '21467'
file_name: PaperSchematics.svg
file_size: 1951210
relation: main_file
success: 1
- access_level: open_access
checksum: 9ac1054b16c212c6f34d402dce2c80e0
content_type: application/octet-stream
creator: snaik
date_created: 2026-03-21T03:37:43Z
date_updated: 2026-03-21T03:37:43Z
file_id: '21468'
file_name: maxwell_sketch.tex
file_size: 1897
relation: main_file
success: 1
- access_level: open_access
checksum: 7c9ecf78e2593b3830d96fa94baa08df
content_type: application/x-zip-compressed
creator: snaik
date_created: 2026-03-24T07:21:43Z
date_updated: 2026-03-24T07:21:43Z
file_id: '21495'
file_name: DataRepo.zip
file_size: 749368723
relation: main_file
success: 1
file_date_updated: 2026-03-24T07:21:43Z
fulldoi: https://doi.org/10.15479/AT-ISTA-21137
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '3'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 8f060199-16d5-11f0-9cad-f3253b266c46
grant_number: PAT 5044023
name: Keratins in epithelial tissue spreading
- _id: 252C3B08-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1250-B20
name: Nano-Analytics of Cellular Systems
publisher: Institute of Science and Technology Austria
status: public
title: 'Data associated with Keratins coordinate tissue spreading '
tmp:
image: /images/cc_by_sa.png
legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
BY-SA 4.0)
short: CC BY-SA (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: repository
OA_type: free access
_id: '21284'
abstract:
- lang: eng
text: The advantageous characteristics attributed to the 19F nucleus have made it
a popular target for NMR once again in recent years. Aside from solution NMR,
an increasing number of studies have been conducted applying solid-state magic-angle-spinning
NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and
strong dipolar couplings can be utilized to get structural insights into proteins
and measure long distances. Despite increasing popularity and promising benefits,
the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal
T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic
doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled
biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and
13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected
MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially
reduces measurement times of 19F MAS NMR experiments without compromising resolution.
Additionally, we report the chemical-shift assignments of all four fluorotryptophan
signals in the 12 × 39 kDa large protein using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
was supported by the Scientific Service Units (SSU) of Institute of Science and
Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance
Facility and the Lab Support Facility.
article_processing_charge: No
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle
spinning NMR with paramagnetic dopants.” 2026. doi:10.15479/AT-ISTA-21284
apa: Becker, L. M., & Schanda, P. (2026). Research data for “Accelerated 19F
biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of
Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21284
chicago: Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F
Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of
Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21284.
ieee: L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular
magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and
Technology Austria, 2026.
ista: Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular
magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and
Technology Austria, 10.15479/AT-ISTA-21284.
mla: Becker, Lea Marie, and Paul Schanda. Research Data for “Accelerated 19F
Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.” Institute
of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21284.
short: L.M. Becker, P. Schanda, (2026).
contributor:
- contributor_type: researcher
first_name: Giorgia
id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
last_name: Toscano
- contributor_type: researcher
first_name: Anna
id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
last_name: Kapitonova
- contributor_type: researcher
first_name: Rajkumar
id: a3089acd-6806-11ee-bacc-f0c7d500ad20
last_name: Singh
- contributor_type: researcher
first_name: Undina
id: bb74f472-ae54-11eb-9835-bc9c22fb1183
last_name: Guillerm
- contributor_type: researcher
first_name: Roman
last_name: Lichtenecker
corr_author: '1'
date_created: 2026-02-17T10:17:14Z
date_published: 2026-02-18T00:00:00Z
date_updated: 2026-06-10T09:28:41Z
day: '18'
ddc:
- '541'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT-ISTA-21284
file:
- access_level: open_access
checksum: 2d3105f26be578073b88ee1f2ea0bdb1
content_type: application/zip
creator: lbecker
date_created: 2026-02-17T10:11:14Z
date_updated: 2026-02-17T10:11:14Z
file_id: '21285'
file_name: Research_data.zip
file_size: 36996027
relation: main_file
success: 1
- access_level: open_access
checksum: e24aebcdb8856cb181cbaa02de020ddb
content_type: text/plain
creator: lbecker
date_created: 2026-02-17T10:11:14Z
date_updated: 2026-02-17T10:11:14Z
file_id: '21286'
file_name: README.txt
file_size: 1993
relation: table_of_contents
file_date_updated: 2026-02-17T10:11:14Z
fulldoi: https://doi.org/10.15479/AT-ISTA-21284
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '2'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
status: public
title: Research data for "Accelerated 19F biomolecular magic-angle spinning NMR with
paramagnetic dopants"
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21485'
abstract:
- lang: eng
text: Insulating oxides are among the most abundant solid materials in the universe1,2,3.
Of the many ways in which they influence natural phenomena, perhaps the most consequential
is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which
occurs even between samples of the same oxide—yet the symmetry-breaking parameter
that causes this remains unidentified11,12. Here we show that adventitious carbonaceous
molecules adsorbed from the environment are the symmetry-breaking factor in same-material
oxide contact electrification (CE). We use acoustic levitation to measure charge
exchange between a sphere and a plate composed of identical amorphous silicon
dioxide (SiO2). Although charging polarity is random for co-prepared samples,
we control it with baking or plasma treatment. Observing the charge-exchange relaxation
afterwards, we see dynamics over a timescale of hours and connect this directly
to the presence of adventitious carbon with time-of-flight mass spectrometry,
low-energy ion scattering and infrared spectroscopy. Going further, we confirm
that adventitious carbon can even determine charge exchange among different oxides.
Our results identify the symmetry-breaking parameter that causes insulating oxides
to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6,
while simultaneously highlighting an overlooked factor in CE more broadly.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
- _id: LifeSc
acknowledgement: This project has received support from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant
agreement no. 754411). We acknowledge the state of Lower Austria and the European
Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges
support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research
was supported by the Scientific Service Units of the Institute of Science and Technology
Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility,
Scientific Computing facility and Lab Support Facility. We thank the Modic group
for the use of the Laue camera, T. Zauner for the photography of the experimental
set-up and R. Möller for insightful discussions. Open access funding provided by
Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Galien M
full_name: Grosjean, Galien M
id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425
last_name: Grosjean
orcid: 0000-0001-5154-417X
- first_name: Markus
full_name: Ostermann, Markus
last_name: Ostermann
- first_name: Markus
full_name: Sauer, Markus
last_name: Sauer
- first_name: Michael
full_name: Hahn, Michael
last_name: Hahn
- first_name: Christian M.
full_name: Pichler, Christian M.
last_name: Pichler
- first_name: Florian
full_name: Fahrnberger, Florian
last_name: Fahrnberger
- first_name: Felix
full_name: Pertl, Felix
id: 6313aec0-15b2-11ec-abd3-ed67d16139af
last_name: Pertl
orcid: 0000-0003-0463-5794
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Mason M.
full_name: Link, Mason M.
last_name: Link
- first_name: Seong H.
full_name: Kim, Seong H.
last_name: Kim
- first_name: Devin L.
full_name: Schrader, Devin L.
last_name: Schrader
- first_name: Adriana
full_name: Blanco, Adriana
last_name: Blanco
- first_name: Francisco
full_name: Gracia, Francisco
last_name: Gracia
- first_name: Nicolás
full_name: Mujica, Nicolás
last_name: Mujica
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
citation:
ama: Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry
in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w
apa: Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger,
F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide
contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w
chicago: Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian
M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks
Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-025-10088-w.
ieee: G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide
contact electrification,” Nature, vol. 651, no. 8106. Springer Nature,
pp. 626–631, 2026.
ista: Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl
F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis
SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification.
Nature. 651(8106), 626–631.
mla: Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact
Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp.
626–31, doi:10.1038/s41586-025-10088-w.
short: G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger,
F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia,
N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.
corr_author: '1'
date_created: 2026-03-23T15:04:00Z
date_published: 2026-03-18T00:00:00Z
date_updated: 2026-04-28T12:06:01Z
day: '18'
ddc:
- '540'
department:
- _id: ScWa
- _id: GradSch
- _id: LifeSc
doi: 10.1038/s41586-025-10088-w
ec_funded: 1
external_id:
pmid:
- '41851325'
file:
- access_level: open_access
checksum: dafef9ed575b44be4263e948a47ae056
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T06:57:08Z
date_updated: 2026-03-24T06:57:08Z
file_id: '21494'
file_name: 2026_Nature_Grosjean.pdf
file_size: 12245694
relation: main_file
success: 1
file_date_updated: 2026-03-24T06:57:08Z
fulldoi: https://doi.org/10.1038/s41586-025-10088-w
has_accepted_license: '1'
intvolume: ' 651'
issue: '8106'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 626-631
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
call_identifier: H2020
grant_number: '949120'
name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/
status: public
title: Adventitious carbon breaks symmetry in oxide contact electrification
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 651
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21490'
abstract:
- lang: eng
text: Auxin canalization is a self-organizing process that governs the flexible
formation of vasculature by reinforcing the formation of auxin transport channels.
A key prerequisite is the feedback between auxin signaling and directional auxin
transport, mediated by PIN transporters. Despite the developmental importance
of canalization, the molecular components linking auxin perception to the regulation
of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel
and essential component of auxin canalization that links intracellular auxin signaling
with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23
transcriptional auxin signaling. tow mutants exhibit defects in regeneration and
de novo vasculature formation, along with impaired formation of polarized, PIN-expressing
auxin channels. At the subcellular level, these mutants display disrupted auxin-induced
PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes
predominantly to the plasma membrane, where it interacts with receptor-like kinases
involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR
complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at
the cell surface. Together, our findings identify TOW as a molecular link between
intracellular and cell surface auxin signaling mechanisms that converge on PIN
trafficking and polarity, providing new insights into how auxin signaling regulates
directional auxin transport for the self-organizing formation of vasculature during
flexible plant development.
acknowledged_ssus:
- _id: MassSpec
- _id: Bio
- _id: LifeSc
acknowledgement: We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9
system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof.
Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions,
and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also
acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging
& Optics Facility, and the Lab Support Facility at the Institute of Science and
Technology Austria. This research was supported by the Scientific Service Units
(SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF)
and the Lab Support Facility (LSF). The work conducted by the Friml group was funded
by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS)
and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the
core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant
Sciences Core Facility of CEITEC Masaryk University. E.M. received support from
the National Science Centre (NCN), Poland, through the OPUS call within the Weave
programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next
GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes
Amos Comenius.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Nikola
full_name: Rydza, Nikola
last_name: Rydza
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023
apa: Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026).
Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin
canalization. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.023
chicago: Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński,
and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters
for Auxin Canalization.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.023.
ieee: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology,
vol. 36, no. 6. Elsevier, p. 1468–1480.e6, 2026.
ista: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
36(6), 1468–1480.e6.
mla: Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes
PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no.
6, Elsevier, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023.
short: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology
36 (2026) 1468–1480.e6.
corr_author: '1'
date_created: 2026-03-23T15:11:16Z
date_published: 2026-03-23T00:00:00Z
date_updated: 2026-03-24T08:36:40Z
day: '23'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.cub.2026.02.023
external_id:
pmid:
- '41831441'
file:
- access_level: open_access
checksum: fe6c41fdab58a55df5f2a5860c02acdc
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T08:34:37Z
date_updated: 2026-03-24T08:34:37Z
file_id: '21496'
file_name: 2026_CurrentBiology_Li.pdf
file_size: 12986894
relation: main_file
success: 1
file_date_updated: 2026-03-24T08:34:37Z
fulldoi: https://doi.org/10.1016/j.cub.2026.02.023
has_accepted_license: '1'
intvolume: ' 36'
issue: '6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1468-1480.e6
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd906599-d553-11ed-ba76-abf8547645d7
grant_number: E271
name: Identification of a novel regulator in auxin canalization
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for
auxin canalization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21750'
abstract:
- lang: eng
text: Liquid-like superionic conductors, with highly mobile ions in a rigid framework,
offer intrinsically low lattice thermal conductivity without compromising electronic
transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives
lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its
low carrier concentration limits the power factor. Here, interstitial Ag atoms
raise the Fermi level into the conduction band, substantially increasing the electron
concentration. Simultaneously, the formation of a secondary Ag2Se phase generates
lattice distortions that enhance phonon scattering. A pronounced mismatch between
electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples
charge and heat transport, enabling concurrent suppression of κL and retention
of high electrical conductivity. This coupled electronic-phononic modulation yields
a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins,
with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves
6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy
for high-performance midtemperature thermoelectrics.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: The Scientific Service Units (SSU) of ISTA supported this research
through resources provided by the Lab Support Facility (LSF). This work was supported
by the National Key R&D Program of China grant 2024YFE0105200 (to C.S.), National
Natural Science Foundation of China grant 12504038 (to M.L.), China Postdoctoral
Science Foundation grant 2023M743151 (to M.L.), Natural Science Foundation of Henan
Province grant 252300421763 (to M.L.), Key Scientific Research Project of Higher
Education Institutions in Henan Province grant 25A140004 (to M.L.), National Natural
Science Foundation of China grant 12204156 (to D.W.), China Postdoctoral Science
Foundation grant 2023TQ0315 and 2023 M743224 (to D.W.), Generalitat de Catalunya
grant 2021SGR00457 (to J.A.), and European Regional Development Fund grants ENE2016-77798-C4-3-R,
PID2020-116093RB-C43, and AEI/10.13039/501100011033 (to A.C.). This work also was
financially supported by ISTA and the Werner Siemens Foundation (to M.I.).
article_number: eaec9073
article_processing_charge: Yes
article_type: original
author:
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Xueke
full_name: Zhao, Xueke
last_name: Zhao
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Jing
full_name: Yu, Jing
last_name: Yu
- first_name: Xuyang
full_name: Liu, Xuyang
last_name: Liu
- first_name: Mochen
full_name: Jia, Mochen
last_name: Jia
- first_name: Hongzhang
full_name: Song, Hongzhang
last_name: Song
- first_name: Dongyang
full_name: Wang, Dongyang
last_name: Wang
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Chongxin
full_name: Shan, Chongxin
last_name: Shan
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
- first_name: Ziyu
full_name: Wang, Ziyu
last_name: Wang
citation:
ama: Li M, Zhao X, Zhang Y, et al. Electronic-phononic decoupling and Fermi-level
tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances.
2026;12(15). doi:10.1126/sciadv.aec9073
apa: Li, M., Zhao, X., Zhang, Y., Yu, J., Liu, X., Jia, M., … Wang, Z. (2026). Electronic-phononic
decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6.
Science Advances. AAAS. https://doi.org/10.1126/sciadv.aec9073
chicago: Li, Mengyao, Xueke Zhao, Yu Zhang, Jing Yu, Xuyang Liu, Mochen Jia, Hongzhang
Song, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning Enable High
Thermoelectric Performance in Ag8SnSe6.” Science Advances. AAAS, 2026.
https://doi.org/10.1126/sciadv.aec9073.
ieee: M. Li et al., “Electronic-phononic decoupling and Fermi-level tuning
enable high thermoelectric performance in Ag8SnSe6,” Science Advances,
vol. 12, no. 15. AAAS, 2026.
ista: Li M, Zhao X, Zhang Y, Yu J, Liu X, Jia M, Song H, Wang D, Arbiol J, Ibáñez
M, Shan C, Cabot A, Wang Z. 2026. Electronic-phononic decoupling and Fermi-level
tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances. 12(15),
eaec9073.
mla: Li, Mengyao, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning
Enable High Thermoelectric Performance in Ag8SnSe6.” Science Advances,
vol. 12, no. 15, eaec9073, AAAS, 2026, doi:10.1126/sciadv.aec9073.
short: M. Li, X. Zhao, Y. Zhang, J. Yu, X. Liu, M. Jia, H. Song, D. Wang, J. Arbiol,
M. Ibáñez, C. Shan, A. Cabot, Z. Wang, Science Advances 12 (2026).
date_created: 2026-04-19T22:07:47Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-05-06T06:08:27Z
day: '10'
ddc:
- '530'
department:
- _id: MaIb
doi: 10.1126/sciadv.aec9073
external_id:
pmid:
- '41961944'
file:
- access_level: open_access
checksum: 9bd4546a23f218972f83164fb21003e1
content_type: application/pdf
creator: dernst
date_created: 2026-05-06T06:06:26Z
date_updated: 2026-05-06T06:06:26Z
file_id: '21802'
file_name: 2026_ScienceAdv_Li.pdf
file_size: 3727993
relation: main_file
success: 1
file_date_updated: 2026-05-06T06:06:26Z
fulldoi: https://doi.org/10.1126/sciadv.aec9073
has_accepted_license: '1'
intvolume: ' 12'
issue: '15'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric
performance in Ag8SnSe6
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21763'
abstract:
- lang: eng
text: Reactive oxygen species (ROS) have been implicated in multiple signaling processes
in plants, but the underlying mechanisms and roles remain enigmatic. In this study,
we developed a method of live imaging of apoplastic ROS at the root surface. Distinct
signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization
factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts.
Genetic and optogenetic manipulations of Arabidopsis identified calcium transients
as necessary and sufficient for ROS bursts through activation of reduced nicotinamide
adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS
bursts are not required, but they do limit gravity-induced root bending. Root
bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH
oxidase activation. The resulting ROS production stiffens cell walls to facilitate
soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility
and stiffness to navigate soil.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We gratefully acknowledge the Lab Support Facility (LSF) and the
Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility
(University of Nottingham) for support with imaging and the Growth Facility (IPMB)
for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics
upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing
of Arabidopsis mini-soil columns.\r\nThis project received funding from the European
Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B).
I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030
and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research
and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding
from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported
by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government
through its “Investments for the Future” program and also by the projects “Mecha-Nuc”
ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support
by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges
support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université
Paris-Saclay. Phytohormonal analysis was performed using the service laboratory
funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of
the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This
research was funded in whole or in part by the Austrian Science Fund (P 37051-B)
and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by
the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required,
the author will make the Author Accepted Manuscript (AAM) version available under
a CC BY public copyright license."
article_processing_charge: No
article_type: original
author:
- first_name: Ivan
full_name: Kulich, Ivan
id: 57a1567c-8314-11eb-9063-c9ddc3451a54
last_name: Kulich
- first_name: Dmitrii
full_name: Vladimirtsev, Dmitrii
id: 60466724-5355-11ee-ae5a-fa55e8f99c3d
last_name: Vladimirtsev
- first_name: Marek
full_name: Randuch, Marek
id: 6ac4636d-15b2-11ec-abd3-fb8df79972ae
last_name: Randuch
- first_name: Shiqiang
full_name: Gao, Shiqiang
last_name: Gao
- first_name: Matteo
full_name: Citterico, Matteo
last_name: Citterico
- first_name: Kai R.
full_name: Konrad, Kai R.
last_name: Konrad
- first_name: Georg
full_name: Nagel, Georg
last_name: Nagel
- first_name: Michael
full_name: Wrzaczek, Michael
last_name: Wrzaczek
- first_name: Léa
full_name: Cascaro, Léa
last_name: Cascaro
- first_name: Pauline
full_name: Vinet, Pauline
last_name: Vinet
- first_name: Pauline
full_name: Durand, Pauline
last_name: Durand
- first_name: Atef
full_name: Asnacios, Atef
last_name: Asnacios
- first_name: Lokesh
full_name: Verma, Lokesh
last_name: Verma
- first_name: Malcolm J.
full_name: Bennett, Malcolm J.
last_name: Bennett
- first_name: Bipin K.
full_name: Pandey, Bipin K.
last_name: Pandey
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS
bursts balance gravity and mechanical signals for soil navigation. Science.
2026;392(6795):296-300. doi:10.1126/science.adu8197
apa: Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad,
K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. AAAS. https://doi.org/10.1126/science.adu8197
chicago: Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo
Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS
Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” Science.
AAAS, 2026. https://doi.org/10.1126/science.adu8197.
ieee: I. Kulich et al., “Calcium-triggered apoplastic ROS bursts balance
gravity and mechanical signals for soil navigation,” Science, vol. 392,
no. 6795. AAAS, pp. 296–300, 2026.
ista: Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel
G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ,
Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity
and mechanical signals for soil navigation. Science. 392(6795), 296–300.
mla: Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity
and Mechanical Signals for Soil Navigation.” Science, vol. 392, no. 6795,
AAAS, 2026, pp. 296–300, doi:10.1126/science.adu8197.
short: I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad,
G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma,
M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300.
corr_author: '1'
date_created: 2026-04-26T22:01:47Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-05-07T06:20:07Z
day: '16'
ddc:
- '580'
department:
- _id: JiFr
- _id: GradSch
doi: 10.1126/science.adu8197
external_id:
pmid:
- '41990180'
file:
- access_level: open_access
checksum: eb5b29247832ecdc53c8146da0509bbe
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T05:54:43Z
date_updated: 2026-05-07T05:54:43Z
file_id: '21832'
file_name: 2026_Science_Kulich_accepted.pdf
file_size: 6150733
relation: main_file
success: 1
file_date_updated: 2026-05-07T05:54:43Z
fulldoi: https://doi.org/10.1126/science.adu8197
has_accepted_license: '1'
intvolume: ' 392'
issue: '6795'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Accepted Version
page: 296-300
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals
for soil navigation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21776'
abstract:
- lang: eng
text: Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis,
yet their broader adoption is limited by the lack of a practical method to prepare
these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination
protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine,
and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents.
These conditions streamline ligand library synthesis and will facilitate systematic
studies in catalysis and related applications.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
- _id: NMR
- _id: M-Shop
acknowledgement: We gratefully acknowledge ISTA for generous financial support. B.P.
acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical
Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support.
This research was supported by the Scientific Service Units (SSU) of ISTA through
resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility,
and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for
HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities
at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul
J. and Margaret M. Bender. Open Access funding provided by Institute of Science
and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT
1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003)
and (CHE-1048642).
article_number: e70417
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
full_name: Petrik, Adam
id: e273d403-329f-11ee-a353-8c34c056f8ed
last_name: Petrik
- first_name: Aleksander
full_name: Bena, Aleksander
id: 4197c39e-e8ec-11ed-86cb-afed934cd664
last_name: Bena
- first_name: Haralds
full_name: Baunis, Haralds
id: 2eea55ec-e8ec-11ed-86cb-d9c76787acfe
last_name: Baunis
- first_name: Riley M.
full_name: Kelch, Riley M.
last_name: Kelch
- first_name: Tehshik P.
full_name: Yoon, Tehshik P.
last_name: Yoon
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted
pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417
apa: Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber,
B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis
& Catalysis. Wiley. https://doi.org/10.1002/adsc.70417
chicago: Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik
P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.”
Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417.
ieee: A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile
access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis,
vol. 368, no. 9. Wiley, 2026.
ista: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access
to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9),
e70417.
mla: Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced
Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417.
short: A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced
Synthesis & Catalysis 368 (2026).
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-05-07T07:33:33Z
day: '05'
ddc:
- '540'
department:
- _id: BaPi
- _id: GradSch
doi: 10.1002/adsc.70417
file:
- access_level: open_access
checksum: afe9752977898642c903abdc70b4a283
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T07:29:24Z
date_updated: 2026-05-07T07:29:24Z
file_id: '21833'
file_name: 2026_AdvSynthCatal_Petrik.pdf
file_size: 437184
relation: main_file
success: 1
file_date_updated: 2026-05-07T07:29:24Z
fulldoi: https://doi.org/10.1002/adsc.70417
has_accepted_license: '1'
intvolume: ' 368'
issue: '9'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 8f1d607d-16d5-11f0-9cad-ab453295ba5e
grant_number: PAT 1250924
name: Photoactive ligands for transformative nickel catalysis
publication: Advanced Synthesis & Catalysis
publication_identifier:
eissn:
- 1615-4169
issn:
- 1615-4150
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Facile access to N-substituted pyridyl ligands
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2026'
...
---
OA_place: publisher
_id: '21863'
abstract:
- lang: eng
text: "Atoms and photons, two things so different but yet so alike. The former,
the building block of matter, something we learn about in school and imagine it
as some tiny marbles encircled by other tinier marbles. The latter, an electromagnetic
wave, a light particle or an excitation of the electromagnetic field. Quantum
mechanics tells us about the properties of these two entities. And even if it
sounds, looks and writes counter-intuitive, it has proven right for over a century
now.\r\n\r\nIn this work, I elaborate on how we tested the laws of quantum mechanics
and how we used them learn more about the tiny building blocks of nature and the
fields they use to talk to each other. The atoms we use, are artificial. Superconducting
qubits, small electrical circuits with quantized energy levels behave like electrons
that transition between different orbitals in an atom. One of the qubits' advantages,
is also a big disadvantage. We design the circuits' energy levels and fabricate
them in a cleanroom. This allows for arbitrary spaced energy levels but in contrast
to real atoms, prevents two superconducting qubits from being alike. Still, this
qubit platform is one of the frontrunners for future quantum computing technology
and testing fundamental physics due to their scalability.\r\n\r\nWe interface
superconducting qubits, which operate in the GHz regime, with microwave photons.
We use 3D aluminum cavities as mediators between qubits and photons. The cavities
allow for non-destructive readout of the qubit state, they shield the qubits from
noise at the qubit frequency and they give us an easy way to frequency-tune these
joint systems.\r\n\r\nWe need to operate superconducting qubits and their cavities
at millikelvin temperatures in dilution refrigerators. At higher temperatures,
superconductivity suffers and even worse, the environment is filled with thermal
noise photons. This poses a fundamental limitation on the scalability of superconducting
qubit devices. Also connecting multiple devices in different fridges does not
work over room temperature links because the microwave photons used for this purpose
will be covered in noise and the quantum information they carry, will be unusable.\r\n\r\nInfrared
photons do not suffer from this noise problem since there are close to zero thermal
noise photons at their frequencies at room temperature. We cannot simply interface
superconducting devices with optical photons due their frequency mismatch and
the destructive effect of optical photons on superconductors. Therefore, we use
microwave-to-optics transducers that allow to convert microwave photons into optical
ones and vice-versa. The transducers that we use are macroscopic electro-optic
transducers using the Pockels effect in a disk-shaped Lithium Niobate whispering
gallery mode resonator. By using a strong optical pump, photons from the two frequency
domains experience a beam-splitter interaction and get converted from one to the
other.\r\n\r\nWe measure the generated optical photons using elaborate optical
setups, optical heterodyning and single photon detectors to gain knowledge about
the qubit state or the converted microwave photons. Bridging the microwave and
the optical world allows us to take advantage of both of their strengths but it
also requires deep knowledge about both of their working principles.\r\n\r\nIn
this work, we describe two experiments that our group conducted to showcase the
opportunities that arise from interfacing superconducting qubits with optical
photons but also the pitfalls, one may encounter on the way.\r\n\r\nIn the first
experiment, we managed to all-optically read out a superconducting qubit. We show
that the assignment fidelity, the probability that a measurement of the qubit
state matches the prepared state, is close to equal for all-optical, microwave-to-optics
and conventional microwave readout. We show T1 and T2 measurements for all three
readout types and give an analysis of the noise caused by the optics. Finally,
we show that the infrared light does not affect the qubit performance in a negative
way but that the heating it causes does. This is an important insight that we
used in the next experiment.\r\n\r\nThe second experiment is the upconversion
of itinerant single microwave photons to the optical domain. We show that we can
generate single microwave photons from a qubit-cavity system. We upconvert these
single photons, measure them with a single photon detector and reconstruct their
shape. By conducting a single photon Rabi measurement, we show correlations between
the microwave and the optical domain. And by thorough signal-to-noise measurements
and noise analysis, we find that we can generate single infrared photons with
high signal-to-noise ratio 5.1 and low transducer added noise (<0.012 quanta).
We show that this measurement creates a path towards entanglement of a superconducting
qubit and an optical photon and what parameters need to be improved to achieve
it. Additionally, this experiment is a proof of principle for an on-demand infrared
single photon source. More generally, it allows to link microwave quantum technology
in general to the optical domain."
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: LifeSc
- _id: SSU
acknowledgement: "The author of this work was supported by the European Research Council
under grant no.\r\n101089099 (ERC CoG cQEO) and the European Union’s Horizon 2020
research and innovation\r\nprogram under grant no. 899354 (FETopen SuperQuLAN).\r\nThis
work was also supported by the European Research Council under grant nos. 758053\r\n(ERC
StG QUNNECT), 101248662 (ERC POC CoupledEOT), and the European Innovation\r\nCouncil
no. 101187231 (PathfinderOpen CIELO). This research was funded in whole or in part\r\nby
the Austrian Science Fund (FWF) [10.55776/F71]. For open access purposes, the author\r\nhas
applied a CC BY public copyright license to any author accepted manuscript version
arising\r\nfrom this submission.\r\niii\r\nMy co-authors in the works mentioned
later acknowledge generous support from the ISTFELLOW program, the NOMIS-ISTA fellowship,
the Horizon Europe Program HORIZONCL4-2022-QUANTUM-01-SGA via Project No. 101113946
OpenSuperQPlus100 and a DOC fellowship of the Austrian Academy of Sciences at IST
Austria.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Thomas
full_name: Werner, Thomas
id: 1fcd8497-dba3-11ea-a45e-c6fbd715f7c7
last_name: Werner
orcid: 0009-0001-2346-5236
citation:
ama: Werner T. Interfacing superconducting qubits with optical photons. 2026. doi:10.15479/AT-ISTA-21863
apa: Werner, T. (2026). Interfacing superconducting qubits with optical photons.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21863
chicago: Werner, Thomas. “Interfacing Superconducting Qubits with Optical Photons.”
Institute of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21863.
ieee: T. Werner, “Interfacing superconducting qubits with optical photons,” Institute
of Science and Technology Austria, 2026.
ista: Werner T. 2026. Interfacing superconducting qubits with optical photons. Institute
of Science and Technology Austria.
mla: Werner, Thomas. Interfacing Superconducting Qubits with Optical Photons.
Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21863.
short: T. Werner, Interfacing Superconducting Qubits with Optical Photons, Institute
of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-05-12T09:04:02Z
date_published: 2026-05-12T00:00:00Z
date_updated: 2026-05-20T13:35:43Z
day: '12'
ddc:
- '530'
- '537'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoFi
doi: 10.15479/AT-ISTA-21863
ec_funded: 1
file:
- access_level: open_access
checksum: a5b4d8dba83f96e955a3625c0eebee98
content_type: application/pdf
creator: twerner
date_created: 2026-05-15T15:53:57Z
date_updated: 2026-05-15T15:53:57Z
file_id: '21879'
file_name: 2026_Werner_Thomas_Thesis.pdf
file_size: 9330516
relation: main_file
- access_level: closed
checksum: b41282beaacfb32472769b9e3b1758d8
content_type: application/x-zip-compressed
creator: twerner
date_created: 2026-05-15T15:54:06Z
date_updated: 2026-05-15T15:54:06Z
file_id: '21880'
file_name: 2026_Werner_Thomas_Thesis.zip
file_size: 9370704
relation: source_file
file_date_updated: 2026-05-15T15:54:06Z
fulldoi: https://doi.org/10.15479/AT-ISTA-21863
has_accepted_license: '1'
keyword:
- Superconducting qubits
- Quantum optics
- Single photons and quantum effects
- Nonlinear optics
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '97'
project:
- _id: bdadfa0d-d553-11ed-ba76-fb85edbd456a
grant_number: '101089099'
name: 'Cavity Quantum Electro Optics: Microwave photonics with nonclassical states'
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '899354'
name: Quantum Local Area Networks with Superconducting Qubits
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 5b807754-ab3d-11f0-914f-ff8c34502cc9
grant_number: '101248662'
name: Integrated optical coupling for low loss electro-optic interconnects
- _id: 91aaf765-16d5-11f0-9cad-a8e7e44cccb7
grant_number: '101187231'
name: 'Cavity-Integrated Electro-Optics: Measuring, Converting and Manipulating
Microwaves with Light'
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
- _id: bdb7cfc1-d553-11ed-ba76-d2eaab167738
grant_number: '101080139'
name: Open Superconducting Quantum Computers (OpenSuperQPlus)
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
name: NOMIS Fellowship Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '19073'
relation: part_of_dissertation
status: public
- id: '21870'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
title: Interfacing superconducting qubits with optical photons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21914'
abstract:
- lang: eng
text: 'Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved
in diverse signaling pathways across both animals and plants. While the role of
3′,5′-cAMP has been extensively characterized, the biological significance of
its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in
plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling
systems in Arabidopsis thaliana, with different enzymatic origins and largely
distinct downstream effects. In vitro enzymatic assays show that plant adenylate
cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from
ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP
from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct
yet partially overlapping metabolic, proteomic, and transcriptional response:
2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while
3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis.
Our findings establish the existence of dual cAMP signaling systems in plants,
each with specialized functions and provide insights into the complex regulatory
networks governing plant physiology.'
acknowledged_ssus:
- _id: MassSpec
- _id: LifeSc
acknowledgement: " We thank J. Chai and D. Yu for providing the MBP-fused L7TIR plasmid
and K. Jaworski (Nicolaus Copernicus University) for the GST-HpAC1 plasmid. We
also thank M. Randuch and L. Fiedler for providing vectors for recombinant AFB5
and ADCY. We are also grateful to E. Dutkiewicz, L. Trübestein, N. Krasnici and
A. Michaelis for excellent technical\r\nassistance. We acknowledge the support of
the LSF Mass Spectrometry Service and the Lab\r\nSupport Facility at the Institute
of Science and Technology Austria for their contributions,\r\nincluding consultation
on size exclusion chromatography, LC/MS experimental design,\r\nmetabolomics sample
preparation, LC/MS method optimization, data acquisition, raw data\r\nanalysis,
and absolute quantification. This project is supported by the European\r\nResearch
Council (ERC) under the European Union’s Horizon 2020 research and innovation\r\nprogram
(101142681 CYNIPS) and Austrian Science Fund (FWF; P 37051-B), both to J.Friml.\r\nWe
acknowledge the generous support of the Taif University Researchers Supporting\r\nProject:
TURSP-HC2022/02 and Max-Planck-Society to A.S. "
article_number: aea7828
article_processing_charge: Yes
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Monika
full_name: Chodasiewicz, Monika
last_name: Chodasiewicz
- first_name: Malavika
full_name: Muraleedharan, Malavika
last_name: Muraleedharan
- first_name: Israel M.
full_name: Lopez, Israel M.
last_name: Lopez
- first_name: Michal
full_name: Gorka, Michal
last_name: Gorka
- first_name: Olga
full_name: Kerber, Olga
last_name: Kerber
- first_name: Saqer S.
full_name: Alotaibi, Saqer S.
last_name: Alotaibi
- first_name: Andrew D.L.
full_name: Nelson, Andrew D.L.
last_name: Nelson
- first_name: Rene
full_name: Lenobel, Rene
last_name: Lenobel
- first_name: Jaroslava
full_name: Friedecká, Jaroslava
last_name: Friedecká
- first_name: Aleksandra
full_name: Skirycz, Aleksandra
last_name: Skirycz
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Chodasiewicz M, Muraleedharan M, et al. Biogenesis and downstream effects
of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. 2026;12(19).
doi:10.1126/sciadv.aea7828
apa: Li, M., Chodasiewicz, M., Muraleedharan, M., Lopez, I. M., Gorka, M., Kerber,
O., … Friml, J. (2026). Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP
isomers in plants. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aea7828
chicago: Li, Mingyue, Monika Chodasiewicz, Malavika Muraleedharan, Israel M. Lopez,
Michal Gorka, Olga Kerber, Saqer S. Alotaibi, et al. “Biogenesis and Downstream
Effects of 3’,5’ and 2’,3’ CAMP Isomers in Plants.” Science Advances. AAAS,
2026. https://doi.org/10.1126/sciadv.aea7828.
ieee: M. Li et al., “Biogenesis and downstream effects of 3’,5’ and 2’,3’
cAMP isomers in plants,” Science Advances, vol. 12, no. 19. AAAS, 2026.
ista: Li M, Chodasiewicz M, Muraleedharan M, Lopez IM, Gorka M, Kerber O, Alotaibi
SS, Nelson ADL, Lenobel R, Friedecká J, Skirycz A, Friml J. 2026. Biogenesis and
downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances.
12(19), aea7828.
mla: Li, Mingyue, et al. “Biogenesis and Downstream Effects of 3’,5’ and 2’,3’ CAMP
Isomers in Plants.” Science Advances, vol. 12, no. 19, aea7828, AAAS, 2026,
doi:10.1126/sciadv.aea7828.
short: M. Li, M. Chodasiewicz, M. Muraleedharan, I.M. Lopez, M. Gorka, O. Kerber,
S.S. Alotaibi, A.D.L. Nelson, R. Lenobel, J. Friedecká, A. Skirycz, J. Friml,
Science Advances 12 (2026).
corr_author: '1'
date_created: 2026-05-24T22:01:31Z
date_published: 2026-05-08T00:00:00Z
date_updated: 2026-06-02T14:36:41Z
day: '08'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1126/sciadv.aea7828
external_id:
pmid:
- '42102187'
file:
- access_level: open_access
checksum: 75b8ef2db078652c750e34e9cd98a808
content_type: application/pdf
creator: dernst
date_created: 2026-06-02T14:33:55Z
date_updated: 2026-06-02T14:33:55Z
file_id: '21941'
file_name: 2026_ScienceAdv_Li2.pdf
file_size: 2014452
relation: main_file
success: 1
file_date_updated: 2026-06-02T14:33:55Z
fulldoi: https://doi.org/10.1126/sciadv.aea7828
has_accepted_license: '1'
intvolume: ' 12'
issue: '19'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21962'
abstract:
- lang: eng
text: The generation of faithful cell-type diversity and correct projection neuron
numbers is essential for cerebral cortex development. Corticogenesis is however
susceptible to genetic interference of critical signaling pathways, including
mutations in Mtor/Rptor that lead to microcephaly. How the loss of Rptor/mTORC1
function affects cortical developmental programs, at single cell level, is still
unknown. Here, we utilized Mosaic Analysis with Double Markers (MADM) technology
to probe Rptor gene function upon sparse single cell- or global tissue-wide ablation.
We found that tissue-wide effects drive the etiology of cortical microcephaly
upon loss of Rptor, rather than deficits in projection neuron genesis. Conversely,
Rptor function is cell-autonomously required for postnatal projection neuron survival
in a highly cell-type-specific manner. Collectively, our results suggest that
the fine balance of precise cell-type-specific cell-autonomous Rptor/mTORC1 function
in concert with non-cell-autonomous tissue-wide effects is essential for the development
of a properly-sized cerebral cortex with accurate projection neuron diversity.
acknowledged_ssus:
- _id: PreCl
- _id: LifeSc
- _id: MassSpec
- _id: Bio
acknowledgement: "We thank A. Heger (IST Austria Preclinical Facility), A. Sommer
(VBCF GmbH, NGS Unit), and A.\r\nNicolas (IST Austria Lab Support Facility / Mass
Spectrometry Facility) for technical support; K. Ferencak,\r\nI. Aykara, P. Hirschfeld,
E. Fisher, S. Laukoter, L. Andersen for initial experiments and/or assistance; and\r\nall
members of the Hippenmeyer lab for discussion. This research was supported by the
Scientific Service\r\nUnits (SSU) of IST Austria through resources provided by the
Imaging and Optics- (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF).
R.B. received support from FWF Meitner-Programm (M 2416). This\r\nwork was also
supported by IST Austria institutional funds; the People Programme (Marie Curie
Actions)\r\nof the European Union’s Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement\r\nNo 618444 to S.H., and the European Research Council
(ERC) under the European Union’s Horizon 2020\r\nresearch and innovation programme
(grant agreement No 725780 LinPro) to S.H."
article_processing_charge: No
author:
- first_name: Ana
full_name: Villalba Requena, Ana
id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
last_name: Villalba Requena
orcid: 0000-0002-5615-5277
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Thomas
full_name: Krausgruber, Thomas
last_name: Krausgruber
- first_name: Martin
full_name: Senekowitsch, Martin
last_name: Senekowitsch
- first_name: Matthias
full_name: Farlik, Matthias
last_name: Farlik
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Villalba Requena A, Beattie RJ, Pauler F, et al. Mtor/Rptor function globally
prevents cortical microcephaly and cell-autonomously promotes postnatal neuron
survival in cell type specific manner. bioRxiv. doi:10.64898/2026.05.01.722172
apa: Villalba Requena, A., Beattie, R. J., Pauler, F., Streicher, C., Miranda, O.,
Krausgruber, T., … Hippenmeyer, S. (n.d.). Mtor/Rptor function globally prevents
cortical microcephaly and cell-autonomously promotes postnatal neuron survival
in cell type specific manner. bioRxiv. https://doi.org/10.64898/2026.05.01.722172
chicago: Villalba Requena, Ana, Robert J Beattie, Florian Pauler, Carmen Streicher,
Osvaldo Miranda, Thomas Krausgruber, Martin Senekowitsch, et al. “Mtor/Rptor Function
Globally Prevents Cortical Microcephaly and Cell-Autonomously Promotes Postnatal
Neuron Survival in Cell Type Specific Manner.” BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722172.
ieee: A. Villalba Requena et al., “Mtor/Rptor function globally prevents
cortical microcephaly and cell-autonomously promotes postnatal neuron survival
in cell type specific manner,” bioRxiv. .
ista: Villalba Requena A, Beattie RJ, Pauler F, Streicher C, Miranda O, Krausgruber
T, Senekowitsch M, Farlik M, Bock C, Rülicke T, Hippenmeyer S. Mtor/Rptor function
globally prevents cortical microcephaly and cell-autonomously promotes postnatal
neuron survival in cell type specific manner. bioRxiv, 10.64898/2026.05.01.722172.
mla: Villalba Requena, Ana, et al. “Mtor/Rptor Function Globally Prevents Cortical
Microcephaly and Cell-Autonomously Promotes Postnatal Neuron Survival in Cell
Type Specific Manner.” BioRxiv, doi:10.64898/2026.05.01.722172.
short: A. Villalba Requena, R.J. Beattie, F. Pauler, C. Streicher, O. Miranda, T.
Krausgruber, M. Senekowitsch, M. Farlik, C. Bock, T. Rülicke, S. Hippenmeyer,
BioRxiv (n.d.).
date_created: 2026-06-09T08:08:18Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-06-16T08:45:25Z
day: '05'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.64898/2026.05.01.722172
ec_funded: 1
fulldoi: https://doi.org/10.64898/2026.05.01.722172
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.64898/2026.05.01.722172
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 264E56E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02416
name: Molecular Mechanisms Regulating Gliogenesis in the Neocortex
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618444'
name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: bioRxiv
publication_status: submitted
status: public
title: Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously
promotes postnatal neuron survival in cell type specific manner
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21963'
abstract:
- lang: eng
text: The cerebral cortex consists of immense numbers of neuronal and glial cell-types
derived from radial glial progenitor (RGP) cells. How RGPs generate appropriate
quantities of distinct cortical cell-types to safeguard a brain of correct size,
is not well understood. However, genetic aberration in human, including mutations
in PTEN, lead to cortical malformation such as macrocephaly, albeit with unknown
etiology. Here we utilized Mosaic Analysis with Double Markers (MADM)-based clonal
analysis and single cell phenotyping to decipher the role of Pten in neurogenic
and gliogenic RGP lineage progression during cortical ontogeny. While neurogenic
RGP lineage progression and projection neuron production was moderately altered
in the absence of Pten, cortical astrocyte production was drastically increased.
Through genetic epistasis experiments we show that the loss of Pten uncouples
astrocyte generation from essential growth factor signaling hubs, funneling into
MAPK. Collectively, our results suggest that Pten regulates RGP lineage progression
with distinct sequential functions in cortical projection neurogenesis and astrocyte
production to ensure the emergence of a correctly-sized cerebral cortex.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: "We thank Kay-Uwe Wagner (Wayne State University) for generously
sharing Jak1/2–flox mouse lines; A.\r\nSommer (VBCF GmbH, NGS Unit) for technical
support; N. Kim, V. Mick, S. Schnabl, S. Gobeil, and L.\r\nAndersen for technical
assistance; all members of the Hippenmeyer lab for discussion and B. Novitch for\r\ncomments
on earlier versions of the manuscript. This research was supported by the Scientific
Service Units\r\n(SSU) of IST Austria through resources provided by the Imaging
and Optics Facility (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF).
O.A.M received support from the Austrian Academy of Sciences\r\nÖAW (DOC 186584),
and N.A. from FWF Elise Richter Program (Grant V1041T). This work was also\r\nsupported
by IST Austria institutional funds; FWF SFB F78 (Neuro Stem Modulation) to S.H.,
and the\r\nEuropean Research Council (ERC) under the European Union’s Horizon 2020
research and innovation\r\nprogramme (grant agreement No 725780 LinPro) to S.H."
article_processing_charge: No
author:
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Amarbayasgalan
full_name: Davaatseren, Amarbayasgalan
id: 70ADC922-B424-11E9-99E3-BA18E6697425
last_name: Davaatseren
- first_name: Nicole
full_name: Amberg, Nicole
id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
last_name: Amberg
orcid: 0000-0002-3183-8207
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Ana
full_name: Villalba Requena, Ana
id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
last_name: Villalba Requena
orcid: 0000-0002-5615-5277
- first_name: Anna-Magdalena
full_name: Heger, Anna-Magdalena
id: 4B76FFD2-F248-11E8-B48F-1D18A9856A87
last_name: Heger
- first_name: Corentine
full_name: Marie, Corentine
last_name: Marie
- first_name: Bassem A.
full_name: Hassan, Bassem A.
last_name: Hassan
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Miranda O, Contreras X, Pauler F, et al. Pten orchestrates neurogenic radial
glia lineage progression and tunes neocortical astrocyte production. bioRxiv.
doi:10.64898/2026.05.01.722191
apa: Miranda, O., Contreras, X., Pauler, F., Davaatseren, A., Amberg, N., Streicher,
C., … Hippenmeyer, S. (n.d.). Pten orchestrates neurogenic radial glia lineage
progression and tunes neocortical astrocyte production. bioRxiv. https://doi.org/10.64898/2026.05.01.722191
chicago: Miranda, Osvaldo, Ximena Contreras, Florian Pauler, Amarbayasgalan Davaatseren,
Nicole Amberg, Carmen Streicher, Ana Villalba Requena, et al. “Pten Orchestrates
Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte Production.”
BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722191.
ieee: O. Miranda et al., “Pten orchestrates neurogenic radial glia lineage
progression and tunes neocortical astrocyte production,” bioRxiv. .
ista: Miranda O, Contreras X, Pauler F, Davaatseren A, Amberg N, Streicher C, Villalba
Requena A, Heger A-M, Marie C, Hassan BA, Rülicke T, Hippenmeyer S. Pten orchestrates
neurogenic radial glia lineage progression and tunes neocortical astrocyte production.
bioRxiv, 10.64898/2026.05.01.722191.
mla: Miranda, Osvaldo, et al. “Pten Orchestrates Neurogenic Radial Glia Lineage
Progression and Tunes Neocortical Astrocyte Production.” BioRxiv, doi:10.64898/2026.05.01.722191.
short: O. Miranda, X. Contreras, F. Pauler, A. Davaatseren, N. Amberg, C. Streicher,
A. Villalba Requena, A.-M. Heger, C. Marie, B.A. Hassan, T. Rülicke, S. Hippenmeyer,
BioRxiv (n.d.).
corr_author: '1'
date_created: 2026-06-09T08:08:53Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-06-16T08:57:20Z
day: '05'
ddc:
- '570'
department:
- _id: SiHi
- _id: PreCl
- _id: GradSch
doi: 10.64898/2026.05.01.722191
ec_funded: 1
fulldoi: https://doi.org/10.64898/2026.05.01.722191
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.64898/2026.05.01.722191
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
grant_number: F7805
name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
Mechanisms of Neural Stem Cell Lineage Progression
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: bioRxiv
publication_status: submitted
status: public
title: Pten orchestrates neurogenic radial glia lineage progression and tunes neocortical
astrocyte production
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: green
_id: '22276'
abstract:
- lang: eng
text: Tissue tension is a key determinant of tissue shape, and its regulation is
essential for both morphogenesis and the maintenance of tissue integrity. During
zebrafish embryogenesis, the enveloping layer (EVL) – an epithelial monolayer
covering the blastoderm – undergoes extensive spreading that is driven by pulling
forces exerted at its margin and more than doubles its surface area. Yet whether
and how the EVL actively regulates its tissue tension during this process remains
unclear. Here, we show that the EVL maintains constant tissue tension while spreading,
and that it achieves this by reducing apical cell contractility in response to
the same pulling forces that drive its spreading. We identify a mechanosensitive
pathway underlying this response, mediated by the scaffold/adaptor protein Kibra
regulating the activity of atypical protein kinase C (aPKC) at the apical domain
of EVL cells. Under low mechanical stretch, Kibra forms condensates at the base
of actin-based apical projections, where it activates Myosin II to increase apical
contractility through aPKC downregulation. As mechanical stretch increases, apical
projections disassemble, Kibra condensates dissolve, and aPKC activity rises.
Elevated aPKC activity in turn reduces apical contractility by reducing Myosin
II activity, thereby maintaining constant tissue tension despite increased mechanical
stretch. Together, these findings reveal a mechanosensitive mechanism that enables
robust adaptation of tissue tension to changing mechanical stretch, ensuring efficient
tissue spreading and morphogenesis.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: EM-Fac
acknowledgement: We thank all members of the Heisenberg group for discussion and feedback
on the manuscript, and the Imaging and Optics Facility, the Life Science Support
Facility and the Electron Microscopy Facility of the Institute of Science and Technology
Austria (ISTA) for their continued support. We are grateful to M. Sonawane (Tata
Institute of Fundamental Research, India) for providing the pCS2-HA-aPKC (PKCι)-V260F
(DN) and pCS2-HA-aPKC (PKCι)-A122E (CA) plasmids, and to I. Mayer for the discussion.
Molecular graphics and analyses were performed with UCSF ChimeraX, developed by
the Resource for Biocomputing, Visualization, and Informatics at the University
of California, San Francisco, with support from National Institutes of Health R01-GM129325
and the Office of Cyber Infrastructure and Computational Biology, National Institute
of Allergy and Infectious Diseases. This research was funded in whole or in part
by the Austrian Science Fund (FWF; grant no. PAT5044023) to C.-P.H., and by a JSPS
Overseas Research Fellowship and an EMBO Postdoctoral Fellowship (ALTF 16-2022)
to N.H.
article_processing_charge: No
author:
- first_name: Naoya
full_name: Hino, Naoya
id: 5299a9ce-7679-11eb-a7bc-d1e62b936307
last_name: Hino
- first_name: Tushna
full_name: Kapoor, Tushna
id: e3b3eda7-fd4d-11eb-8fd8-c40af7a478b1
last_name: Kapoor
- first_name: Uday R
full_name: Gubbala, Uday R
id: bb4a0dc4-32c9-11ee-b5ce-a97ceedd5924
last_name: Gubbala
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Hino N, Kapoor T, Gubbala UR, Hannezo EB, Heisenberg C-PJ. Apical domain mechanosensation
regulates tissue tension homeostasis.
apa: Hino, N., Kapoor, T., Gubbala, U. R., Hannezo, E. B., & Heisenberg, C.-P.
J. (n.d.). Apical domain mechanosensation regulates tissue tension homeostasis.
Institute of Science and Technology Austria.
chicago: Hino, Naoya, Tushna Kapoor, Uday R Gubbala, Edouard B Hannezo, and Carl-Philipp
J Heisenberg. “Apical Domain Mechanosensation Regulates Tissue Tension Homeostasis.”
Institute of Science and Technology Austria, n.d.
ieee: N. Hino, T. Kapoor, U. R. Gubbala, E. B. Hannezo, and C.-P. J. Heisenberg,
“Apical domain mechanosensation regulates tissue tension homeostasis.” Institute
of Science and Technology Austria.
ista: Hino N, Kapoor T, Gubbala UR, Hannezo EB, Heisenberg C-PJ. Apical domain mechanosensation
regulates tissue tension homeostasis.
mla: Hino, Naoya, et al. Apical Domain Mechanosensation Regulates Tissue Tension
Homeostasis. Institute of Science and Technology Austria.
short: N. Hino, T. Kapoor, U.R. Gubbala, E.B. Hannezo, C.-P.J. Heisenberg, (n.d.).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "The MATLAB code for image analysis, and the full model
code, including all parameter values\r\nand condition-specific settings, are available
on GitHub at https://github.com/uday2607/EVL-tension-homeostasis.git."
date_created: 2026-07-13T09:03:26Z
date_published: 2026-07-14T00:00:00Z
date_updated: 2026-07-14T07:07:41Z
day: '14'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
- _id: GradSch
file:
- access_level: open_access
checksum: 66444afd243dce7d383d52d44e8d34a4
content_type: application/pdf
creator: nhino
date_created: 2026-07-13T09:16:20Z
date_updated: 2026-07-13T09:16:20Z
file_id: '22283'
file_name: Main_text_and_figures.pdf
file_size: 12477675
relation: main_file
success: 1
- access_level: open_access
checksum: 90bceb34de64ec792c5de117f0890d05
content_type: application/pdf
creator: nhino
date_created: 2026-07-13T09:16:25Z
date_updated: 2026-07-13T09:16:25Z
file_id: '22284'
file_name: Supplementary_figures.pdf
file_size: 4545901
relation: main_file
success: 1
- access_level: open_access
checksum: 9d9ab89c372142f2ffb6c8c625334d7f
content_type: video/mp4
creator: nhino
date_created: 2026-07-13T09:16:28Z
date_updated: 2026-07-13T09:16:28Z
file_id: '22285'
file_name: Supplementary_Video1.mp4
file_size: 10349451
relation: main_file
success: 1
file_date_updated: 2026-07-13T09:16:28Z
has_accepted_license: '1'
keyword:
- Epithelial spreading
- tissue tension
- mechanosensation
- aPKC
- Kibra
- zebrafish
language:
- iso: eng
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 8f060199-16d5-11f0-9cad-f3253b266c46
grant_number: PAT 5044023
name: Keratins in epithelial tissue spreading
- _id: 34dd7f3b-11ca-11ed-8bc3-856f2c87f5da
grant_number: LTF 16-2022
name: Mechanosensitive signaling activation in the crosstalk between mechanical
force and tissuefluidity
publication_status: draft
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '21864'
relation: earlier_version
status: public
researchdata_availability: yes
status: public
supplementarymaterial: yes
title: Apical domain mechanosensation regulates tissue tension homeostasis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '22333'
abstract:
- lang: eng
text: RNA polymerase II (Pol II) must be assembled in the cytoplasm before it enters
the nucleus, where it transcribes protein-coding genes. Although transcription
by Pol II is intensively studied, how this central multi-subunit enzyme is made
and the role of dedicated assembly factors remains unclear. Here, we report the
integrative structural analysis of a native human Pol II from the cytoplasm captured
near the end of biogenesis. The complex contains Gdown1 and three biogenesis factors
– RPAP2 and the critical small GTPases GPN1 and GPN3. Cryo-EM analysis of the
complex reveals how Gdown1 and RPAP2 associate with Pol II and prevent the premature
association of transcription factors. Further biochemical and cryo-EM analysis
reveals how RPAP2 tethers GPN1–GPN3 to the complex and how the assembly of the
RPAP2–GPN1–GPN3 complex is controlled by GTP hydrolysis. The combined results
uncover a network of interactions that chaperone cytoplasmic Pol II to prevent
aberrant interactions, reveal a molecular switch regulating biogenesis factor
association, and suggest a general mechanism for the action of GPN-loop GTPase
family of enzymes.
acknowledged_ssus:
- _id: LifeSc
- _id: EM-Fac
- _id: ScienComp
- _id: PreCl
acknowledgement: We thank A. Salmazo for assistance with Pol II purification. We thank
staff at the Vienna BioCenter Core Facilities (VBCF) Proteomics facility for immunoprecipitation-mass
spectrometry analysis, and J.A. Stopp for assistance with IP-MS data visualization.
This research was further supported by the Scientific Service Units (SSUs) of ISTA
through resources provided by the Lab Support Facility (LSF), Electron Microscopy
Facility (EMF), Scientific Computing (SciComp), and the Preclinical Facility (PCF).
F.H. was funded by the Endowed Professorship of the Lower Austria Research Funding
Agency (GFF NÖ) and by the Austrian Research Promotion Agency (FFG) through the
COIN Establishment Grant n.o. 45624401.
article_processing_charge: Yes
article_type: original
author:
- first_name: Annamaria
full_name: Hlavata, Annamaria
id: 36062FEC-F248-11E8-B48F-1D18A9856A87
last_name: Hlavata
- first_name: Benjamin
full_name: Neuditschko, Benjamin
last_name: Neuditschko
- first_name: Ulla
full_name: Schellhaas, Ulla
last_name: Schellhaas
- first_name: Clemens
full_name: Plaschka, Clemens
last_name: Plaschka
- first_name: Franz
full_name: Herzog, Franz
last_name: Herzog
- first_name: Carrie A
full_name: Bernecky, Carrie A
id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
last_name: Bernecky
orcid: 0000-0003-0893-7036
biorxivid: 1
citation:
ama: Hlavata A, Neuditschko B, Schellhaas U, Plaschka C, Herzog F, Bernecky C. Structure
of cytoplasmic RNA polymerase II. Nature Communications. 2026. doi:10.1038/s41467-026-75416-8
apa: Hlavata, A., Neuditschko, B., Schellhaas, U., Plaschka, C., Herzog, F., &
Bernecky, C. (2026). Structure of cytoplasmic RNA polymerase II. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-026-75416-8
chicago: Hlavata, Annamaria, Benjamin Neuditschko, Ulla Schellhaas, Clemens Plaschka,
Franz Herzog, and Carrie Bernecky. “Structure of Cytoplasmic RNA Polymerase II.”
Nature Communications. Springer Nature, 2026. https://doi.org/10.1038/s41467-026-75416-8.
ieee: A. Hlavata, B. Neuditschko, U. Schellhaas, C. Plaschka, F. Herzog, and C.
Bernecky, “Structure of cytoplasmic RNA polymerase II,” Nature Communications.
Springer Nature, 2026.
ista: Hlavata A, Neuditschko B, Schellhaas U, Plaschka C, Herzog F, Bernecky C.
2026. Structure of cytoplasmic RNA polymerase II. Nature Communications.
mla: Hlavata, Annamaria, et al. “Structure of Cytoplasmic RNA Polymerase II.” Nature
Communications, Springer Nature, 2026, doi:10.1038/s41467-026-75416-8.
short: A. Hlavata, B. Neuditschko, U. Schellhaas, C. Plaschka, F. Herzog, C. Bernecky,
Nature Communications (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "The\r\nc ryo EM maps generated in this study were deposited
to the EM Data Bank under the\r\naccession codes: EMD 55583 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55583\r\n(Pol II Gdown1 RPAP2 composite map), EMD 55578\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55578 Pol II Gdown1 RPAP2 Pol II core\r\nmap EMD 55579 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55579 Pol II\r\nGdown1 RPAP2 Pol II stalk map EMD 55580\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55580 Pol II Gdown1 RPAP2 RPAP2\r\nmap EMD 55581 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55 581 Pol II\r\nGdown1 RPAP2 Gdown1 N terminus map EMD 55582\r\n[https://www.ebi.ac.uk/pdbe/entry/emdb/EMD
55582 Pol II Gdown1 RPAP2 Gdown1\r\nC terminus map and EMD 55585 [https://www.ebi.ac.uk/pdbe/entry/emdb/EMD\r\n55585
RPAP2 GPN1 GPN3 map Model coordi nates were deposited to the PDBe under\r\nthe accession
codes: 9T5H [http://doi.org/10.2210/pdb 9T5H / (Pol II Gdown1\r\nRPAP2 complex structure)
and 9T5J [http://doi.org/10.2210/pdb 9T5H / (GPN1\r\nGPN3 RPAP2 structure). Immunoprecipitation
mass spectrometry and crosslinking mass\r\nspectrometry proteomics data have been
deposited to the ProteomeXchange Consortium\r\nvia the PRIDE partner repository
with the dataset identifiers PXD071638\r\n[http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD
071638 and\r\nP XD070852\r\n[http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD
070852\r\nAlphaFold3 structure predictions have been deposited to the Zenodo repository\r\nhttps://doi.org/10.5281/zenodo.20687910
P reviously published model coordinates\r\nwere utilized and are available at the
PDB under the accession codes 8QEP\r\n[http://doi.org/10.2210/pdb 8QEP / 9BZ 0 [http://doi.org/10.2210/pdb
9BZ 0 /\r\nand 7B7U [http://doi.org/10.2210/pdb 7B7U / Source Data are provided
with this\r\npaper."
date_created: 2026-07-14T07:27:59Z
date_published: 2026-07-13T00:00:00Z
date_updated: 2026-07-16T11:29:31Z
day: '13'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.1038/s41467-026-75416-8
external_id:
biorxivid:
- 10.64898/2025.12.10.692585
fulldoi: https://doi.org/10.1038/s41467-026-75416-8
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-026-75416-8
month: '07'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Structure of cytoplasmic RNA polymerase II
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21777'
abstract:
- lang: eng
text: The advantageous characteristics attributed to the 19F nucleus have made it
a popular target for nuclear magnetic resonance (NMR) once again in recent years.
Aside from solution NMR, an increasing number of studies have been conducted applying
solid-state magic-angle spinning (MAS) NMR to fluorine-labelled samples. Here,
the high chemical shift anisotropy and strong dipolar couplings can be utilised
to get structural insights into proteins and measure long distances. Despite increasing
popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR
often suffers from slow longitudinal T1 relaxation and therefore long recycle
delays. In this work, we expand paramagnetic doping, an approach commonly used
to reduce proton T1 relaxation times, to 19F-labelled biological samples. We study
the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F T1 and T2, and 13C T1 and T2 relaxation
in a [5-19F13C]-tryptophan-labelled protein via 19F-detected MAS NMR experiments.
The observed paramagnetic relaxation enhancement substantially reduces measurement
times of 19F MAS NMR experiments without compromising resolution. Additionally,
we report the chemical shift assignments of all four fluorotryptophan signals
in the 12×39 kDa-large protein TET2 using a mutagenesis approach.
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: We thank Ben P. Tatman for insightful discussions. This research
was supported by the Scientific Service Units (SSUs) of ISTA through resources provided
by the Nuclear Magnetic Resonance Facility and the Lab Support Facility. We thank
Prof. Tobias Madl (Medical University Graz) for a sample of Omniscan. Lea M. Becker
is the recipient of a DOC fellowship of the Austrian Academy of Sciences at the
Institute of Science and Technology Austria (grant no. PR10660EAW01).
article_processing_charge: Yes
article_type: original
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Giorgia
full_name: Toscano, Giorgia
id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
last_name: Toscano
- first_name: Anna
full_name: Kapitonova, Anna
id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
last_name: Kapitonova
- first_name: Rajkumar
full_name: Singh, Rajkumar
id: a3089acd-6806-11ee-bacc-f0c7d500ad20
last_name: Singh
- first_name: Undina
full_name: Guillerm, Undina
id: bb74f472-ae54-11eb-9835-bc9c22fb1183
last_name: Guillerm
- first_name: Roman J.
full_name: Lichtenecker, Roman J.
last_name: Lichtenecker
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Toscano G, Kapitonova A, et al. Accelerated 19F biomolecular magic-angle
spinning NMR with paramagnetic dopants. Magnetic Resonance. 2026;7(1):29-37.
doi:10.5194/mr-7-29-2026
apa: Becker, L. M., Toscano, G., Kapitonova, A., Singh, R., Guillerm, U., Lichtenecker,
R. J., & Schanda, P. (2026). Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants. Magnetic Resonance. Copernicus Publications.
https://doi.org/10.5194/mr-7-29-2026
chicago: Becker, Lea Marie, Giorgia Toscano, Anna Kapitonova, Rajkumar Singh, Undina
Guillerm, Roman J. Lichtenecker, and Paul Schanda. “Accelerated 19F Biomolecular
Magic-Angle Spinning NMR with Paramagnetic Dopants.” Magnetic Resonance.
Copernicus Publications, 2026. https://doi.org/10.5194/mr-7-29-2026.
ieee: L. M. Becker et al., “Accelerated 19F biomolecular magic-angle spinning
NMR with paramagnetic dopants,” Magnetic Resonance, vol. 7, no. 1. Copernicus
Publications, pp. 29–37, 2026.
ista: Becker LM, Toscano G, Kapitonova A, Singh R, Guillerm U, Lichtenecker RJ,
Schanda P. 2026. Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic
dopants. Magnetic Resonance. 7(1), 29–37.
mla: Becker, Lea Marie, et al. “Accelerated 19F Biomolecular Magic-Angle Spinning
NMR with Paramagnetic Dopants.” Magnetic Resonance, vol. 7, no. 1, Copernicus
Publications, 2026, pp. 29–37, doi:10.5194/mr-7-29-2026.
short: L.M. Becker, G. Toscano, A. Kapitonova, R. Singh, U. Guillerm, R.J. Lichtenecker,
P. Schanda, Magnetic Resonance 7 (2026) 29–37.
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-07-20T09:49:12Z
day: '16'
ddc:
- '540'
department:
- _id: PaSc
- _id: GradSch
doi: 10.5194/mr-7-29-2026
external_id:
pmid:
- '42057802'
fulldoi: https://doi.org/10.5194/mr-7-29-2026
has_accepted_license: '1'
intvolume: ' 7'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.5194/mr-7-29-2026
month: '04'
oa: 1
oa_version: Published Version
page: 29-37
pmid: 1
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 7be609c4-9f16-11ee-852c-85015ce2b9b0
grant_number: '26777'
name: Exploring protein dynamics by solid-state MAS NMR through specific labeling
approaches
publication: Magnetic Resonance
publication_identifier:
eissn:
- 2699-0016
publication_status: published
publisher: Copernicus Publications
quality_controlled: '1'
related_material:
record:
- id: '22334'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22371'
abstract:
- lang: eng
text: Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization
of organelles within cells, including endo-lysosomes, is a prerequisite of migration.
However, how ultrastructural polarization is linked to the signaling requirements
governing T cell migration remains unknown. Here we show that signaling molecules
generated by endo-lysosome-localized kinases regulate velocity of amoeboid migration.
Specifically, imaging of T cells identifies accumulation of endo-lysosomes decorated
with the lipid kinases VPS34–PIKfyve at the uropod of polarized cells. Activity
of VPS34 and PIKfyve regulates speed, but not directedness, of migrating T cells.
Mechanistically, PI(3,5)P2 generated by the sequential action of VPS34 and PIKfyve,
mediates Ca2+ efflux from lysosomes via the mucolipin TRP cation channel 1 (TRPML1),
thus controlling activity of myosin IIA and hence the generation of propulsive
force through retrograde actin flow. The VPS34–PIKfyve kinases also regulate velocity
of myeloid cells, as well as of the amoeba Dictyostelium discoideum – establishing
the axis as an evolutionarily conserved speed control system of amoeboid cell
migration.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank the microscopy core facility of the Department of Biomedicine
at the University and University Hospital of Basel for their technical support.
This research was technically supported by the Scientific Service Units (SSU) of
ISTA through resources provided by the Imaging & Optics Facility (IOF) and the Lab
Support Facility (LSF). CH was supported by the Swiss National Science Foundation
(SNSF) (310030B_201277; 310030_192677; FZEB-0-180487), the ZBF Program Award 2025
(Hans Zäslin Bustany Foundation), and the Novartis Foundation for Medical-Biological
Research (NFMBR) (#23A070). PD was supported by the Swiss Academy for Medical Sciences
(SAMW) and SNSF (183980, 225441), the NFMBR (#23A070), AlumniMedizin Basel, and
the Freiwillige Akademische Gesellschaft Basel. DFL was supported by the SNSF (220205).
Open access funding provided by University of Basel.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Philippe G
full_name: Dehio, Philippe G
id: b769738e-a003-11ee-b1b8-9030316e0d59
last_name: Dehio
- first_name: Céline
full_name: Michard, Céline
last_name: Michard
- first_name: Juan Carlos
full_name: Yam-Puc, Juan Carlos
last_name: Yam-Puc
- first_name: Adrià Arnau
full_name: Martí I Líndez, Adrià Arnau
last_name: Martí I Líndez
- first_name: Anett
full_name: Jandke, Anett
last_name: Jandke
- first_name: Gunhild
full_name: Unterstab, Gunhild
last_name: Unterstab
- first_name: Lucien
full_name: Fabre, Lucien
last_name: Fabre
- first_name: Loïc
full_name: Sauteur, Loïc
last_name: Sauteur
- first_name: Marc
full_name: Artinger, Marc
last_name: Artinger
- first_name: Daniel F.
full_name: Legler, Daniel F.
last_name: Legler
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Thorsten
full_name: Schaefer, Thorsten
last_name: Schaefer
- first_name: Matthias P.
full_name: Wymann, Matthias P.
last_name: Wymann
- first_name: Klaus
full_name: Okkenhaug, Klaus
last_name: Okkenhaug
- first_name: Thierry
full_name: Soldati, Thierry
last_name: Soldati
- first_name: Matthias
full_name: Mehling, Matthias
id: 3C23B994-F248-11E8-B48F-1D18A9856A87
last_name: Mehling
orcid: 0000-0001-8599-1226
- first_name: Christoph
full_name: Hess, Christoph
last_name: Hess
citation:
ama: Dehio PG, Michard C, Yam-Puc JC, et al. A conserved VPS34-PIKfyve-TRPML1-myosin
II axis regulates the speed of amoeboid cell migration. EMBO Reports. 2026.
doi:10.1038/s44319-026-00861-x
apa: Dehio, P. G., Michard, C., Yam-Puc, J. C., Martí I Líndez, A. A., Jandke, A.,
Unterstab, G., … Hess, C. (2026). A conserved VPS34-PIKfyve-TRPML1-myosin II axis
regulates the speed of amoeboid cell migration. EMBO Reports. Springer
Nature. https://doi.org/10.1038/s44319-026-00861-x
chicago: Dehio, Philippe G, Céline Michard, Juan Carlos Yam-Puc, Adrià Arnau Martí
I Líndez, Anett Jandke, Gunhild Unterstab, Lucien Fabre, et al. “A Conserved VPS34-PIKfyve-TRPML1-Myosin
II Axis Regulates the Speed of Amoeboid Cell Migration.” EMBO Reports.
Springer Nature, 2026. https://doi.org/10.1038/s44319-026-00861-x.
ieee: P. G. Dehio et al., “A conserved VPS34-PIKfyve-TRPML1-myosin II axis
regulates the speed of amoeboid cell migration,” EMBO Reports. Springer
Nature, 2026.
ista: Dehio PG, Michard C, Yam-Puc JC, Martí I Líndez AA, Jandke A, Unterstab G,
Fabre L, Sauteur L, Artinger M, Legler DF, Sixt MK, Schaefer T, Wymann MP, Okkenhaug
K, Soldati T, Mehling M, Hess C. 2026. A conserved VPS34-PIKfyve-TRPML1-myosin
II axis regulates the speed of amoeboid cell migration. EMBO Reports.
mla: Dehio, Philippe G., et al. “A Conserved VPS34-PIKfyve-TRPML1-Myosin II Axis
Regulates the Speed of Amoeboid Cell Migration.” EMBO Reports, Springer
Nature, 2026, doi:10.1038/s44319-026-00861-x.
short: P.G. Dehio, C. Michard, J.C. Yam-Puc, A.A. Martí I Líndez, A. Jandke, G.
Unterstab, L. Fabre, L. Sauteur, M. Artinger, D.F. Legler, M.K. Sixt, T. Schaefer,
M.P. Wymann, K. Okkenhaug, T. Soldati, M. Mehling, C. Hess, EMBO Reports (2026).
das_tickbox: '1'
dataavailabilitystatement: "The analysis workflow to quantify vesicle localization
can be accessed on GitHub (https://github.com/loicsauteur/vesicle-analysis, version
0.1.1).\r\n\r\nThe source data of this paper are collected in the following database
record: biostudies:S-SCDT-10_1038-S44319-026-00861-x."
date_created: 2026-07-19T22:01:48Z
date_published: 2026-07-07T00:00:00Z
date_updated: 2026-07-20T14:28:59Z
day: '07'
department:
- _id: MiSi
doi: 10.1038/s44319-026-00861-x
external_id:
pmid:
- '42414599'
fulldoi: https://doi.org/10.1038/s44319-026-00861-x
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s44319-026-00861-x
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: EMBO Reports
publication_identifier:
eissn:
- 1469-3178
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid
cell migration
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_type: closed access
_id: '21730'
abstract:
- lang: eng
text: Hydrogen peroxide (H2O2) is a crucial member of the reactive oxygen species
(ROS) family, playing roles in cellular signalling and immune responses in human
health. Moreover, it is a potential biomarker of diabetes when present in aberrant
concentrations. Therefore, monitoring trace levels of H2O2 has become a research
hotspot for analytical and sensor chemists. In this context, we report a rhodamine-based
fluorescent probe (RN), which shows excellent fluorescent enhancement at 555 nm
upon the addition of H2O2 along with a low limit of detection (LOD) of 0.67 ppm
and fast response (∼2 min). The probe is highly selective for H2O2, showing no
fluorescence enhancement with other ROS. RN is synthesised in a one-pot chemical
reaction using rhodamine 6G (R6G) and 4,7,10-trioxa-1,13-tridecanediamine (TTDA).
H2O2 detection in pre-treated milk samples proves its real-world viability. We
found that RN shows low cytotoxicity, which allowed us to successfully explore
its potential to monitor H2O2 generation in a diabetic L929 skin cell line and
diabetic mice liver tissue. This result demonstrates promising features for assessing
early diabetic progression through fluorescence imaging.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "MM acknowledges the Government of India for DST-INSPIRE\r\nfellowship
[IF200389] and Federal Ministry of Education, Science and Research (BMBWF) and the
OeAD – Austria’s Agency for Education and Internationalisation for an Ernst Mach
Grant, weltweit (grant number MPC-2024-01518) for research internship at ISTA. The
Scientific Service Units of ISTA supported this research through resources provided
by the Lab Support Facility. PG acknowledges the ANRF, India, for his NPDF fellowship
(File no. PDF/2022/001960). PB acknowledges ANRF, India, for the SERB-CRG sponsored
project GAP-240712 (vide reference no. CRG/2022/001679)."
article_processing_charge: No
article_type: original
author:
- first_name: Moumita
full_name: Mondal, Moumita
last_name: Mondal
- first_name: Pravat
full_name: Ghorai, Pravat
last_name: Ghorai
- first_name: Asmita
full_name: Samadder, Asmita
last_name: Samadder
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Priyabrata
full_name: Banerjee, Priyabrata
last_name: Banerjee
citation:
ama: Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. H2O2 responsive
rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal
of Materials Chemistry B. 2026;14(17):5314-5322. doi:10.1039/d5tb02687c
apa: Mondal, M., Ghorai, P., Samadder, A., Freunberger, S. A., & Banerjee, P.
(2026). H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes
diagnosis. Journal of Materials Chemistry B. Royal Society of Chemistry.
https://doi.org/10.1039/d5tb02687c
chicago: Mondal, Moumita, Pravat Ghorai, Asmita Samadder, Stefan Alexander Freunberger,
and Priyabrata Banerjee. “H2O2 Responsive Rhodamine-Based Probe for Monitoring
Early-Stage Diabetes Diagnosis.” Journal of Materials Chemistry B. Royal
Society of Chemistry, 2026. https://doi.org/10.1039/d5tb02687c.
ieee: M. Mondal, P. Ghorai, A. Samadder, S. A. Freunberger, and P. Banerjee, “H2O2
responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis,”
Journal of Materials Chemistry B, vol. 14, no. 17. Royal Society of Chemistry,
pp. 5314–5322, 2026.
ista: Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. 2026. H2O2 responsive
rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of
Materials Chemistry B. 14(17), 5314–5322.
mla: Mondal, Moumita, et al. “H2O2 Responsive Rhodamine-Based Probe for Monitoring
Early-Stage Diabetes Diagnosis.” Journal of Materials Chemistry B, vol.
14, no. 17, Royal Society of Chemistry, 2026, pp. 5314–22, doi:10.1039/d5tb02687c.
short: M. Mondal, P. Ghorai, A. Samadder, S.A. Freunberger, P. Banerjee, Journal
of Materials Chemistry B 14 (2026) 5314–5322.
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: 'The data supporting this article have been included as
part of the supplementary information (SI). The supplementary information includes
all spectral profiles, plots and tabulated data. See DOI: https://doi.org/10.1039/d5tb02687c.'
date_created: 2026-04-13T07:45:26Z
date_published: 2026-05-06T00:00:00Z
date_updated: 2026-07-27T12:36:05Z
day: '06'
department:
- _id: StFr
doi: 10.1039/d5tb02687c
external_id:
pmid:
- '41958432'
fulldoi: https://doi.org/10.1039/d5tb02687c
intvolume: ' 14'
issue: '17'
language:
- iso: eng
month: '05'
oa_version: None
page: 5314-5322
pmid: 1
publication: Journal of Materials Chemistry B
publication_identifier:
eissn:
- 2050-7518
issn:
- 2050-750X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2026'
...
---
OA_place: repository
_id: '21360'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "I would like to acknowledge the Austrian Academy of Sciences (ÖAW)
and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW
Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stefan
full_name: Riegler, Stefan
id: FF6018E0-D806-11E9-8E43-0B14E6697425
last_name: Riegler
orcid: 0000-0003-3413-1343
citation:
ama: 'Riegler S. Root system plasticity under nutrient limitation: Investigating
hormonal and molecular drivers in Arabidopsis thaliana and Coffea species. 2026.
doi:10.15479/AT-ISTA-21360'
apa: 'Riegler, S. (2026). Root system plasticity under nutrient limitation: Investigating
hormonal and molecular drivers in Arabidopsis thaliana and Coffea species.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-21360'
chicago: 'Riegler, Stefan. “Root System Plasticity under Nutrient Limitation: Investigating
Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species.” Institute
of Science and Technology Austria, 2026. https://doi.org/10.15479/AT-ISTA-21360.'
ieee: 'S. Riegler, “Root system plasticity under nutrient limitation: Investigating
hormonal and molecular drivers in Arabidopsis thaliana and Coffea species,” Institute
of Science and Technology Austria, 2026.'
ista: 'Riegler S. 2026. Root system plasticity under nutrient limitation: Investigating
hormonal and molecular drivers in Arabidopsis thaliana and Coffea species. Institute
of Science and Technology Austria.'
mla: 'Riegler, Stefan. Root System Plasticity under Nutrient Limitation: Investigating
Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species.
Institute of Science and Technology Austria, 2026, doi:10.15479/AT-ISTA-21360.'
short: 'S. Riegler, Root System Plasticity under Nutrient Limitation: Investigating
Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea Species, Institute
of Science and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '1'
date_created: 2026-02-27T09:08:14Z
date_published: 2026-02-26T00:00:00Z
date_updated: 2026-07-27T14:30:08Z
day: '26'
ddc:
- '570'
- '575'
- '583'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/AT-ISTA-21360
doi_confirm: '1'
file:
- access_level: closed
checksum: 2f1f44e8536c2538f94a440217452c9f
content_type: application/x-zip-compressed
creator: sriegler
date_created: 2026-03-02T10:59:50Z
date_updated: 2026-03-02T10:59:50Z
file_id: '21386'
file_name: 2026_Riegler_Stefan_Thesis.zip
file_size: 31430022
relation: source_file
- access_level: closed
checksum: 2e8dc39640bc26ae5684c944c619719b
content_type: application/pdf
creator: sriegler
date_created: 2026-03-02T10:59:49Z
date_updated: 2026-03-02T10:59:49Z
embargo: 2027-02-27
embargo_to: open_access
file_id: '21387'
file_name: 2026_Riegler_Stefan_Thesis.pdf
file_size: 11635090
relation: main_file
file_date_updated: 2026-03-02T10:59:50Z
fulldoi: https://doi.org/10.15479/AT-ISTA-21360
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: Published Version
page: '185'
project:
- _id: 34afa094-11ca-11ed-8bc3-a375845a59fb
grant_number: '101060393'
name: Breeding for coffee and cocoa root resilience in low input farming systems
based on improved rootstocks
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '21363'
relation: research_data
status: public
status: public
supervisor:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
title: 'Root system plasticity under nutrient limitation: Investigating hormonal and
molecular drivers in Arabidopsis thaliana and Coffea species'
tmp:
image: /images/cc_by_sa.png
legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
BY-SA 4.0)
short: CC BY-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...