---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21490'
abstract:
- lang: eng
text: Auxin canalization is a self-organizing process that governs the flexible
formation of vasculature by reinforcing the formation of auxin transport channels.
A key prerequisite is the feedback between auxin signaling and directional auxin
transport, mediated by PIN transporters. Despite the developmental importance
of canalization, the molecular components linking auxin perception to the regulation
of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel
and essential component of auxin canalization that links intracellular auxin signaling
with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23
transcriptional auxin signaling. tow mutants exhibit defects in regeneration and
de novo vasculature formation, along with impaired formation of polarized, PIN-expressing
auxin channels. At the subcellular level, these mutants display disrupted auxin-induced
PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes
predominantly to the plasma membrane, where it interacts with receptor-like kinases
involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR
complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at
the cell surface. Together, our findings identify TOW as a molecular link between
intracellular and cell surface auxin signaling mechanisms that converge on PIN
trafficking and polarity, providing new insights into how auxin signaling regulates
directional auxin transport for the self-organizing formation of vasculature during
flexible plant development.
acknowledged_ssus:
- _id: MassSpec
- _id: Bio
- _id: LifeSc
acknowledgement: We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9
system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof.
Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions,
and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also
acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging
& Optics Facility, and the Lab Support Facility at the Institute of Science and
Technology Austria. This research was supported by the Scientific Service Units
(SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF)
and the Lab Support Facility (LSF). The work conducted by the Friml group was funded
by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS)
and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the
core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant
Sciences Core Facility of CEITEC Masaryk University. E.M. received support from
the National Science Centre (NCN), Poland, through the OPUS call within the Weave
programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next
GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes
Amos Comenius.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Nikola
full_name: Rydza, Nikola
last_name: Rydza
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023
apa: Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026).
Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin
canalization. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.023
chicago: Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński,
and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters
for Auxin Canalization.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.023.
ieee: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology,
vol. 36, no. 6. Elsevier, p. 1468–1480.e6, 2026.
ista: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
36(6), 1468–1480.e6.
mla: Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes
PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no.
6, Elsevier, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023.
short: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology
36 (2026) 1468–1480.e6.
corr_author: '1'
date_created: 2026-03-23T15:11:16Z
date_published: 2026-03-23T00:00:00Z
date_updated: 2026-03-24T08:36:40Z
day: '23'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.cub.2026.02.023
external_id:
pmid:
- '41831441'
file:
- access_level: open_access
checksum: fe6c41fdab58a55df5f2a5860c02acdc
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T08:34:37Z
date_updated: 2026-03-24T08:34:37Z
file_id: '21496'
file_name: 2026_CurrentBiology_Li.pdf
file_size: 12986894
relation: main_file
success: 1
file_date_updated: 2026-03-24T08:34:37Z
has_accepted_license: '1'
intvolume: ' 36'
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 1468-1480.e6
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd906599-d553-11ed-ba76-abf8547645d7
grant_number: E271
name: Identification of a novel regulator in auxin canalization
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for
auxin canalization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21776'
abstract:
- lang: eng
text: Pyridyl motifs equipped with N-substituents can be powerful ligands for catalysis,
yet their broader adoption is limited by the lack of a practical method to prepare
these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination
protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine,
and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N-substituents.
These conditions streamline ligand library synthesis and will facilitate systematic
studies in catalysis and related applications.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
- _id: NMR
- _id: M-Shop
acknowledgement: We gratefully acknowledge ISTA for generous financial support. B.P.
acknowledges the Austrian Science Fund (PAT 1250924) and the ACS GCI Pharmaceutical
Roundtable for funding; T.P.Y acknowledges the NSF(CHE-2349003) for financial support.
This research was supported by the Scientific Service Units (SSU) of ISTA through
resources provided by the Lab Support Facility, Mass Spec Facility, NMR facility,
and the Miba Machine Shop. We specifically thank Aikaterina Paraskevopoulou for
HRMS measurements and Jan Pecak for support with ICP-OES experi-ments. NMR facilities
at UW−Madison were supported by the NSF(CHE-1048642) and a generous gift from Paul
J. and Margaret M. Bender. Open Access funding provided by Institute of Science
and Technology Austria/KEMÖ. This study was supported by Austrian Science Fund (PAT
1250924), ACSGCI Pharmaceutical Roundtable, and National Science Foundation(CHE-2349003)
and (CHE-1048642).
article_number: e70417
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
full_name: Petrik, Adam
id: e273d403-329f-11ee-a353-8c34c056f8ed
last_name: Petrik
- first_name: Aleksander
full_name: Bena, Aleksander
id: 4197c39e-e8ec-11ed-86cb-afed934cd664
last_name: Bena
- first_name: Haralds
full_name: Baunis, Haralds
id: 2eea55ec-e8ec-11ed-86cb-d9c76787acfe
last_name: Baunis
- first_name: Riley M.
full_name: Kelch, Riley M.
last_name: Kelch
- first_name: Tehshik P.
full_name: Yoon, Tehshik P.
last_name: Yoon
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. Facile access to N-substituted
pyridyl ligands. Advanced Synthesis & Catalysis. 2026;368(9). doi:10.1002/adsc.70417
apa: Petrik, A., Bena, A., Baunis, H., Kelch, R. M., Yoon, T. P., & Pieber,
B. (2026). Facile access to N-substituted pyridyl ligands. Advanced Synthesis
& Catalysis. Wiley. https://doi.org/10.1002/adsc.70417
chicago: Petrik, Adam, Aleksander Bena, Haralds Baunis, Riley M. Kelch, Tehshik
P. Yoon, and Bartholomäus Pieber. “Facile Access to N-Substituted Pyridyl Ligands.”
Advanced Synthesis & Catalysis. Wiley, 2026. https://doi.org/10.1002/adsc.70417.
ieee: A. Petrik, A. Bena, H. Baunis, R. M. Kelch, T. P. Yoon, and B. Pieber, “Facile
access to N-substituted pyridyl ligands,” Advanced Synthesis & Catalysis,
vol. 368, no. 9. Wiley, 2026.
ista: Petrik A, Bena A, Baunis H, Kelch RM, Yoon TP, Pieber B. 2026. Facile access
to N-substituted pyridyl ligands. Advanced Synthesis & Catalysis. 368(9),
e70417.
mla: Petrik, Adam, et al. “Facile Access to N-Substituted Pyridyl Ligands.” Advanced
Synthesis & Catalysis, vol. 368, no. 9, e70417, Wiley, 2026, doi:10.1002/adsc.70417.
short: A. Petrik, A. Bena, H. Baunis, R.M. Kelch, T.P. Yoon, B. Pieber, Advanced
Synthesis & Catalysis 368 (2026).
corr_author: '1'
date_created: 2026-05-03T22:01:36Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-05-07T07:33:33Z
day: '05'
ddc:
- '540'
department:
- _id: BaPi
- _id: GradSch
doi: 10.1002/adsc.70417
file:
- access_level: open_access
checksum: afe9752977898642c903abdc70b4a283
content_type: application/pdf
creator: dernst
date_created: 2026-05-07T07:29:24Z
date_updated: 2026-05-07T07:29:24Z
file_id: '21833'
file_name: 2026_AdvSynthCatal_Petrik.pdf
file_size: 437184
relation: main_file
success: 1
file_date_updated: 2026-05-07T07:29:24Z
has_accepted_license: '1'
intvolume: ' 368'
issue: '9'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 8f1d607d-16d5-11f0-9cad-ab453295ba5e
grant_number: PAT 1250924
name: Photoactive ligands for transformative nickel catalysis
publication: Advanced Synthesis & Catalysis
publication_identifier:
eissn:
- 1615-4169
issn:
- 1615-4150
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Facile access to N-substituted pyridyl ligands
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 368
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21914'
abstract:
- lang: eng
text: 'Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved
in diverse signaling pathways across both animals and plants. While the role of
3′,5′-cAMP has been extensively characterized, the biological significance of
its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in
plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling
systems in Arabidopsis thaliana, with different enzymatic origins and largely
distinct downstream effects. In vitro enzymatic assays show that plant adenylate
cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from
ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP
from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct
yet partially overlapping metabolic, proteomic, and transcriptional response:
2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while
3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis.
Our findings establish the existence of dual cAMP signaling systems in plants,
each with specialized functions and provide insights into the complex regulatory
networks governing plant physiology.'
acknowledged_ssus:
- _id: MassSpec
- _id: LifeSc
acknowledgement: " We thank J. Chai and D. Yu for providing the MBP-fused L7TIR plasmid
and K. Jaworski (Nicolaus Copernicus University) for the GST-HpAC1 plasmid. We
also thank M. Randuch and L. Fiedler for providing vectors for recombinant AFB5
and ADCY. We are also grateful to E. Dutkiewicz, L. Trübestein, N. Krasnici and
A. Michaelis for excellent technical\r\nassistance. We acknowledge the support of
the LSF Mass Spectrometry Service and the Lab\r\nSupport Facility at the Institute
of Science and Technology Austria for their contributions,\r\nincluding consultation
on size exclusion chromatography, LC/MS experimental design,\r\nmetabolomics sample
preparation, LC/MS method optimization, data acquisition, raw data\r\nanalysis,
and absolute quantification. This project is supported by the European\r\nResearch
Council (ERC) under the European Union’s Horizon 2020 research and innovation\r\nprogram
(101142681 CYNIPS) and Austrian Science Fund (FWF; P 37051-B), both to J.Friml.\r\nWe
acknowledge the generous support of the Taif University Researchers Supporting\r\nProject:
TURSP-HC2022/02 and Max-Planck-Society to A.S. "
article_number: aea7828
article_processing_charge: Yes
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Monika
full_name: Chodasiewicz, Monika
last_name: Chodasiewicz
- first_name: Malavika
full_name: Muraleedharan, Malavika
last_name: Muraleedharan
- first_name: Israel M.
full_name: Lopez, Israel M.
last_name: Lopez
- first_name: Michal
full_name: Gorka, Michal
last_name: Gorka
- first_name: Olga
full_name: Kerber, Olga
last_name: Kerber
- first_name: Saqer S.
full_name: Alotaibi, Saqer S.
last_name: Alotaibi
- first_name: Andrew D.L.
full_name: Nelson, Andrew D.L.
last_name: Nelson
- first_name: Rene
full_name: Lenobel, Rene
last_name: Lenobel
- first_name: Jaroslava
full_name: Friedecká, Jaroslava
last_name: Friedecká
- first_name: Aleksandra
full_name: Skirycz, Aleksandra
last_name: Skirycz
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Chodasiewicz M, Muraleedharan M, et al. Biogenesis and downstream effects
of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. 2026;12(19).
doi:10.1126/sciadv.aea7828
apa: Li, M., Chodasiewicz, M., Muraleedharan, M., Lopez, I. M., Gorka, M., Kerber,
O., … Friml, J. (2026). Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP
isomers in plants. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aea7828
chicago: Li, Mingyue, Monika Chodasiewicz, Malavika Muraleedharan, Israel M. Lopez,
Michal Gorka, Olga Kerber, Saqer S. Alotaibi, et al. “Biogenesis and Downstream
Effects of 3’,5’ and 2’,3’ CAMP Isomers in Plants.” Science Advances. AAAS,
2026. https://doi.org/10.1126/sciadv.aea7828.
ieee: M. Li et al., “Biogenesis and downstream effects of 3’,5’ and 2’,3’
cAMP isomers in plants,” Science Advances, vol. 12, no. 19. AAAS, 2026.
ista: Li M, Chodasiewicz M, Muraleedharan M, Lopez IM, Gorka M, Kerber O, Alotaibi
SS, Nelson ADL, Lenobel R, Friedecká J, Skirycz A, Friml J. 2026. Biogenesis and
downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances.
12(19), aea7828.
mla: Li, Mingyue, et al. “Biogenesis and Downstream Effects of 3’,5’ and 2’,3’ CAMP
Isomers in Plants.” Science Advances, vol. 12, no. 19, aea7828, AAAS, 2026,
doi:10.1126/sciadv.aea7828.
short: M. Li, M. Chodasiewicz, M. Muraleedharan, I.M. Lopez, M. Gorka, O. Kerber,
S.S. Alotaibi, A.D.L. Nelson, R. Lenobel, J. Friedecká, A. Skirycz, J. Friml,
Science Advances 12 (2026).
corr_author: '1'
date_created: 2026-05-24T22:01:31Z
date_published: 2026-05-08T00:00:00Z
date_updated: 2026-06-02T14:36:41Z
day: '08'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1126/sciadv.aea7828
external_id:
pmid:
- '42102187'
file:
- access_level: open_access
checksum: 75b8ef2db078652c750e34e9cd98a808
content_type: application/pdf
creator: dernst
date_created: 2026-06-02T14:33:55Z
date_updated: 2026-06-02T14:33:55Z
file_id: '21941'
file_name: 2026_ScienceAdv_Li2.pdf
file_size: 2014452
relation: main_file
success: 1
file_date_updated: 2026-06-02T14:33:55Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '19'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21962'
abstract:
- lang: eng
text: The generation of faithful cell-type diversity and correct projection neuron
numbers is essential for cerebral cortex development. Corticogenesis is however
susceptible to genetic interference of critical signaling pathways, including
mutations in Mtor/Rptor that lead to microcephaly. How the loss of Rptor/mTORC1
function affects cortical developmental programs, at single cell level, is still
unknown. Here, we utilized Mosaic Analysis with Double Markers (MADM) technology
to probe Rptor gene function upon sparse single cell- or global tissue-wide ablation.
We found that tissue-wide effects drive the etiology of cortical microcephaly
upon loss of Rptor, rather than deficits in projection neuron genesis. Conversely,
Rptor function is cell-autonomously required for postnatal projection neuron survival
in a highly cell-type-specific manner. Collectively, our results suggest that
the fine balance of precise cell-type-specific cell-autonomous Rptor/mTORC1 function
in concert with non-cell-autonomous tissue-wide effects is essential for the development
of a properly-sized cerebral cortex with accurate projection neuron diversity.
acknowledged_ssus:
- _id: PreCl
- _id: LifeSc
- _id: MassSpec
- _id: Bio
acknowledgement: "We thank A. Heger (IST Austria Preclinical Facility), A. Sommer
(VBCF GmbH, NGS Unit), and A.\r\nNicolas (IST Austria Lab Support Facility / Mass
Spectrometry Facility) for technical support; K. Ferencak,\r\nI. Aykara, P. Hirschfeld,
E. Fisher, S. Laukoter, L. Andersen for initial experiments and/or assistance; and\r\nall
members of the Hippenmeyer lab for discussion. This research was supported by the
Scientific Service\r\nUnits (SSU) of IST Austria through resources provided by the
Imaging and Optics- (IOF), Lab Support-\r\n(LSF) and Preclinical Facilities (PCF).
R.B. received support from FWF Meitner-Programm (M 2416). This\r\nwork was also
supported by IST Austria institutional funds; the People Programme (Marie Curie
Actions)\r\nof the European Union’s Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement\r\nNo 618444 to S.H., and the European Research Council
(ERC) under the European Union’s Horizon 2020\r\nresearch and innovation programme
(grant agreement No 725780 LinPro) to S.H."
article_processing_charge: No
author:
- first_name: Ana
full_name: Villalba Requena, Ana
id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
last_name: Villalba Requena
orcid: 0000-0002-5615-5277
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Osvaldo
full_name: Miranda, Osvaldo
id: 862A3C56-A8BF-11E9-B4FA-D9E3E5697425
last_name: Miranda
orcid: 0000-0001-6618-6889
- first_name: Thomas
full_name: Krausgruber, Thomas
last_name: Krausgruber
- first_name: Martin
full_name: Senekowitsch, Martin
last_name: Senekowitsch
- first_name: Matthias
full_name: Farlik, Matthias
last_name: Farlik
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Villalba Requena A, Beattie RJ, Pauler F, et al. Mtor/Rptor function globally
prevents cortical microcephaly and cell-autonomously promotes postnatal neuron
survival in cell type specific manner. bioRxiv. doi:10.64898/2026.05.01.722172
apa: Villalba Requena, A., Beattie, R. J., Pauler, F., Streicher, C., Miranda, O.,
Krausgruber, T., … Hippenmeyer, S. (n.d.). Mtor/Rptor function globally prevents
cortical microcephaly and cell-autonomously promotes postnatal neuron survival
in cell type specific manner. bioRxiv. https://doi.org/10.64898/2026.05.01.722172
chicago: Villalba Requena, Ana, Robert J Beattie, Florian Pauler, Carmen Streicher,
Osvaldo Miranda, Thomas Krausgruber, Martin Senekowitsch, et al. “Mtor/Rptor Function
Globally Prevents Cortical Microcephaly and Cell-Autonomously Promotes Postnatal
Neuron Survival in Cell Type Specific Manner.” BioRxiv, n.d. https://doi.org/10.64898/2026.05.01.722172.
ieee: A. Villalba Requena et al., “Mtor/Rptor function globally prevents
cortical microcephaly and cell-autonomously promotes postnatal neuron survival
in cell type specific manner,” bioRxiv. .
ista: Villalba Requena A, Beattie RJ, Pauler F, Streicher C, Miranda O, Krausgruber
T, Senekowitsch M, Farlik M, Bock C, Rülicke T, Hippenmeyer S. Mtor/Rptor function
globally prevents cortical microcephaly and cell-autonomously promotes postnatal
neuron survival in cell type specific manner. bioRxiv, 10.64898/2026.05.01.722172.
mla: Villalba Requena, Ana, et al. “Mtor/Rptor Function Globally Prevents Cortical
Microcephaly and Cell-Autonomously Promotes Postnatal Neuron Survival in Cell
Type Specific Manner.” BioRxiv, doi:10.64898/2026.05.01.722172.
short: A. Villalba Requena, R.J. Beattie, F. Pauler, C. Streicher, O. Miranda, T.
Krausgruber, M. Senekowitsch, M. Farlik, C. Bock, T. Rülicke, S. Hippenmeyer,
BioRxiv (n.d.).
date_created: 2026-06-09T08:08:18Z
date_published: 2026-05-05T00:00:00Z
date_updated: 2026-06-16T08:45:25Z
day: '05'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.64898/2026.05.01.722172
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.64898/2026.05.01.722172
month: '05'
oa: 1
oa_version: Preprint
project:
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call_identifier: FWF
grant_number: M02416
name: Molecular Mechanisms Regulating Gliogenesis in the Neocortex
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618444'
name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: bioRxiv
publication_status: submitted
status: public
title: Mtor/Rptor function globally prevents cortical microcephaly and cell-autonomously
promotes postnatal neuron survival in cell type specific manner
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '22734'
abstract:
- lang: eng
text: Silver selenide (Ag2Se) is a promising near-room-temperature thermoelectric
material, but its narrow stoichiometric window and β–α phase transition complicate
reproducible microstructure control. Here, we present a mismatch-assisted microstructure
engineering strategy in which Ag2Se particles are treated with polyanionic ZnSe
complexes and consolidated through the β–α transition to introduce ZnSe nanoprecipitates,
Ag2Se/ZnSe interfaces, and local strain fields. The crystallographic mismatch
between ZnSe and Ag2Se, together with the Zn2+/Ag+ size difference, amplifies
phase-transition-induced deformation and promotes high-density dislocations with
periodic strain modulations. This defect architecture suppresses grain coarsening,
removes excess Ag, limits Ag-interstitial formation, and reduces lattice thermal
conductivity through lattice softening and multiscale phonon scattering. Ag2Se–4%ZnSe
nanocomposites achieve a peak zTmax of 1.13 at 369 K and a zTavg of 1.08 from
300 to 380 K, demonstrating mismatch-driven defect engineering through the β–α
phase transition as a route for optimizing Ag2Se-based thermoelectrics.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: NanoFab
- _id: MassSpec
acknowledgement: 'Open access funding provided by Institute of Science and Technology
Austria. M.I. acknowledges financial support from ISTA and the Werner Siemens Foundation.
The Scientific Service Units (SSU) of ISTA supported this work through resources
provided by the Electron Microscopy Facility (EMF), the Lab Support Facility (LSF),
the Nanofabrication Facility (NNF), and the Mass Spectrometry Facility. Y.L. acknowledges
funding from the National Natural Science Foundation of China (NSFC) (grant no.
22209034) and the Fundamental Research Funds for the Central Universities (JZ2024HGTB0239).
M.H. acknowledges funding from Australian Research Council (FT230100316), and the
high-performance computing resources provided by National Computational Infrastructure
(it39) and Pawsey Supercomputing Centre (pawsey1075). ICN2 acknowledges funding
from Generalitat de Catalunya 2021SGR00457. The authors thank support from the project
AMaDE (PID2023-149158OB-C43), funded by MCIN/AEI/10.13039/501100011033/ and by the
“ERDF Away of making Europe”, by the “European Union”. ICN2 is supported by the
Severo Ochoa program from Spanish MCIN/AEI (grant no.: CEX2021-001214-S) and is
funded by the CERCA Programme/Generalitat de Catalunya. Authors acknowledge the
use of instrumentation as well as the technical advice provided by the Joint Electron
Microscopy Center at ALBA (JEMCA). ICN2 acknowledges funding from Grant IU16-014206
(METCAM-FIB) funded by the European Union through the European Regional Development
Fund (ERDF), with the support of the Ministry of Research and Universities, Generalitat
de Catalunya. ICN2 is founding member of e-DREAM. (91)'
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Tobias
full_name: Kleinhanns, Tobias
id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
last_name: Kleinhanns
orcid: 0000-0003-1537-7436
- first_name: Maria Chiara
full_name: Spadaro, Maria Chiara
last_name: Spadaro
- first_name: Aziz
full_name: Genç, Aziz
last_name: Genç
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Navita
full_name: Navita, Navita
id: 6ebe278d-ba0b-11ee-8184-f34cdc671de4
last_name: Navita
orcid: 0000-0001-7408-8197
- first_name: Tommaso
full_name: Costanzo, Tommaso
id: D93824F4-D9BA-11E9-BB12-F207E6697425
last_name: Costanzo
orcid: 0000-0001-9732-3815
- first_name: Ewelina
full_name: Dutkiewicz, Ewelina
id: 0601cc46-c082-11ec-9b07-bb29641d1de9
last_name: Dutkiewicz
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Min
full_name: Hong, Min
last_name: Hong
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Liu Y, Kleinhanns T, Spadaro MC, et al. Exploiting mismatch strain and the
β–α phase transition for microstructural engineering in thermoelectric Ag2Se.
ACS Energy Letters. 2026;11(8):5752-5762. doi:10.1021/acsenergylett.6c01499
apa: Liu, Y., Kleinhanns, T., Spadaro, M. C., Genç, A., Horta, S., Jakhar, N., …
Ibáñez, M. (2026). Exploiting mismatch strain and the β–α phase transition for
microstructural engineering in thermoelectric Ag2Se. ACS Energy Letters.
American Chemical Society. https://doi.org/10.1021/acsenergylett.6c01499
chicago: Liu, Yu, Tobias Kleinhanns, Maria Chiara Spadaro, Aziz Genç, Sharona Horta,
Navita Jakhar, Tommaso Costanzo, et al. “Exploiting Mismatch Strain and the β–α
Phase Transition for Microstructural Engineering in Thermoelectric Ag2Se.” ACS
Energy Letters. American Chemical Society, 2026. https://doi.org/10.1021/acsenergylett.6c01499.
ieee: Y. Liu et al., “Exploiting mismatch strain and the β–α phase transition
for microstructural engineering in thermoelectric Ag2Se,” ACS Energy Letters,
vol. 11, no. 8. American Chemical Society, pp. 5752–5762, 2026.
ista: Liu Y, Kleinhanns T, Spadaro MC, Genç A, Horta S, Jakhar N, Costanzo T, Dutkiewicz
E, Arbiol J, Hong M, Ibáñez M. 2026. Exploiting mismatch strain and the β–α phase
transition for microstructural engineering in thermoelectric Ag2Se. ACS Energy
Letters. 11(8), 5752–5762.
mla: Liu, Yu, et al. “Exploiting Mismatch Strain and the β–α Phase Transition for
Microstructural Engineering in Thermoelectric Ag2Se.” ACS Energy Letters,
vol. 11, no. 8, American Chemical Society, 2026, pp. 5752–62, doi:10.1021/acsenergylett.6c01499.
short: Y. Liu, T. Kleinhanns, M.C. Spadaro, A. Genç, S. Horta, N. Jakhar, T. Costanzo,
E. Dutkiewicz, J. Arbiol, M. Hong, M. Ibáñez, ACS Energy Letters 11 (2026) 5752–5762.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-18T11:34:03Z
date_published: 2026-08-14T00:00:00Z
date_updated: 2026-08-19T05:53:33Z
day: '14'
ddc:
- '540'
department:
- _id: MassSpec
- _id: MaIb
- _id: GradSch
- _id: EM-Fac
doi: 10.1021/acsenergylett.6c01499
file:
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checksum: 4d75c5a79d112c845c9eecba8838db38
content_type: application/pdf
creator: dernst
date_created: 2026-08-19T05:52:41Z
date_updated: 2026-08-19T05:52:41Z
file_id: '22736'
file_name: 2026_ACSEnergyLetters_Liu.pdf
file_size: 6806815
relation: main_file
success: 1
file_date_updated: 2026-08-19T05:52:41Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '8'
language:
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month: '08'
oa: 1
oa_version: Published Version
page: 5752-5762
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: ACS Energy Letters
publication_identifier:
eissn:
- 2380-8195
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Exploiting mismatch strain and the β–α phase transition for microstructural
engineering in thermoelectric Ag2Se
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2026'
...
---
APC_amount: 7068 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '18892'
abstract:
- lang: eng
text: Sick individuals often conceal their disease status to group members, thereby
preventing social exclusion or aggression. Here we show by behavioural, chemical,
immunological and infection load analyses that sick ant pupae instead actively
emit a chemical signal that in itself is sufficient to trigger their own destruction
by colony members. In our experiments, this altruistic disease-signalling was
performed only by worker but not queen pupae. The lack of signalling by queen
pupae did not constitute cheating behaviour, but reflected their superior immune
capabilities. Worker pupae suffered from extensive pathogen replication whereas
queen pupae were able to restrain their infection. Our data suggest the evolution
of a finely-tuned signalling system in which it is not the induction of an individual’s
immune response, but rather its failure to overcome the infection, that triggers
pupal signalling for sacrifice. This demonstrates a balanced interplay between
individual and social immunity that efficiently achieves whole-colony health.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
acknowledgement: We thank Joergen Eilenberg and Nicolai V. Meyling for the fungal
strain, and the ISTA Social Immunity team, Jonghyun Park and Yuko Ulrich for ant
collection. We also thank the Social Immunity team, in particular David Moreno Martínez,
Tanvi Madaan, Wilfrid Jean Louis and Jessica Kirchner, for experimental and molecular
support, as well as Friedrich Fochler for technical support with the chemical analysis,
and the ISTA Lab Support Facility, including the mass spectrometry unit, for general
and chemical laboratory support. We further thank Marco Ribezzi for advice on 13C
calculations and Ernst Pittenauer for discussion of the chemical data, Chris Pull
and Michael Sixt for project discussion, and the Social Immunity team for comments
on the manuscript. The study was funded by the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation Programme (No. 771402;
EPIDEMICSonCHIP) to SC.
article_number: '10511'
article_processing_charge: Yes
article_type: original
author:
- first_name: Erika
full_name: Dawson, Erika
id: 31B4E2D0-F248-11E8-B48F-1D18A9856A87
last_name: Dawson
- first_name: Michaela
full_name: Hönigsberger, Michaela
id: 953894f3-25bd-11ec-8556-f70a9d38ef60
last_name: Hönigsberger
- first_name: Niklas
full_name: Kampleitner, Niklas
id: 2AC57FAC-F248-11E8-B48F-1D18A9856A87
last_name: Kampleitner
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Lukas
full_name: Lindorfer, Lukas
id: 85f0e6d3-06b3-11ec-8982-8c5049fa4455
last_name: Lindorfer
- first_name: Jennifer
full_name: Robb, Jennifer
id: 7bc2734a-e2c6-11ea-9824-a2ed5f0662a8
last_name: Robb
- first_name: Farnaz
full_name: Beikzadeh Abbasi, Farnaz
id: 0344bfb9-3feb-11ee-87e9-c27edc800bcd
last_name: Beikzadeh Abbasi
- first_name: Florian
full_name: Strahodinsky, Florian
id: 979E35EE-C996-11E9-8C7C-CF13E6697425
last_name: Strahodinsky
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Harikrishnan
full_name: Rajendran, Harikrishnan
id: 876b6b34-8ff4-11ec-97c9-8d95a7aae416
last_name: Rajendran
- first_name: Thomas
full_name: Schmitt, Thomas
last_name: Schmitt
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Dawson E, Hönigsberger M, Kampleitner N, et al. Altruistic disease signalling
in ant colonies. Nature Communications. 2025;16. doi:10.1038/s41467-025-66175-z
apa: Dawson, E., Hönigsberger, M., Kampleitner, N., Grasse, A. V., Lindorfer, L.,
Robb, J., … Cremer, S. (2025). Altruistic disease signalling in ant colonies.
Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-025-66175-z
chicago: Dawson, Erika, Michaela Hönigsberger, Niklas Kampleitner, Anna V Grasse,
Lukas Lindorfer, Jennifer Robb, Farnaz Beikzadeh, et al. “Altruistic Disease Signalling
in Ant Colonies.” Nature Communications. Springer Nature, 2025. https://doi.org/10.1038/s41467-025-66175-z.
ieee: E. Dawson et al., “Altruistic disease signalling in ant colonies,”
Nature Communications, vol. 16. Springer Nature, 2025.
ista: Dawson E, Hönigsberger M, Kampleitner N, Grasse AV, Lindorfer L, Robb J, Beikzadeh
F, Strahodinsky F, Leitner H, Rajendran H, Schmitt T, Cremer S. 2025. Altruistic
disease signalling in ant colonies. Nature Communications. 16, 10511.
mla: Dawson, Erika, et al. “Altruistic Disease Signalling in Ant Colonies.” Nature
Communications, vol. 16, 10511, Springer Nature, 2025, doi:10.1038/s41467-025-66175-z.
short: E. Dawson, M. Hönigsberger, N. Kampleitner, A.V. Grasse, L. Lindorfer, J.
Robb, F. Beikzadeh, F. Strahodinsky, H. Leitner, H. Rajendran, T. Schmitt, S.
Cremer, Nature Communications 16 (2025).
corr_author: '1'
date_created: 2025-01-27T11:28:05Z
date_published: 2025-12-01T00:00:00Z
date_updated: 2026-06-10T08:50:53Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
- _id: LifeSc
doi: 10.1038/s41467-025-66175-z
ec_funded: 1
external_id:
pmid:
- '41330896'
file:
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checksum: 06244623bb7611c636652ecbc4787889
content_type: application/pdf
creator: dernst
date_created: 2025-12-15T13:30:33Z
date_updated: 2025-12-15T13:30:33Z
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file_date_updated: 2025-12-15T13:30:33Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2024.02.27.582277
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/ants-signal-deadly-infection/
record:
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relation: research_data
status: public
scopus_import: '1'
status: public
title: Altruistic disease signalling in ant colonies
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20326'
abstract:
- lang: eng
text: Ag2Se is a promising n-type thermoelectric material, but its performance is
limited by excessive carrier concentration, compositional inhomogeneity, and phase
instability, challenges rooted in a narrow homogeneity range and uncontrolled
Ag+ diffusion in the superionic phase. Here, we address these issues by exploiting
liquid–solid interface reactions using CdSe complexes that remove surface excess
Ag to yield stoichiometric Ag2Se and generate CdSe nanodomains that inhibit Ag+
diffusion and constrain grain growth. The resulting Ag2Se-CdSe nanocomposites
exhibit a reproducible, stable figure of merit (zT) of 1.04 between 300 and 390
K. Beyond demonstrating high performance, we elucidate the interfacial chemical
reactions that give rise to the observed microstructure and transport properties,
providing a foundation for rationally engineering interfacial chemistry to tailor
transport properties across diverse thermoelectric material systems.
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: NanoFab
- _id: MassSpec
acknowledgement: 'M.I. acknowledges financial support from ISTA and the Werner Siemens
Foundation. The Scientific Service Units (SSU) of ISTA supported this work through
resources provided by the Electron Microscopy Facility (EMF), the Lab Support Facility
(LSF) and the Nanofabrication Facility (NNF) and the LSF Mass Spectrometry Service.
The members of the Ibáñez research group are acknowledged, especially Christine
Fiedler for scientific illustration and Ihor Cherniukh for valuable discussions.
Y.L. acknowledges funding from the National Natural Science Foundation of China
(NSFC) (Grants No. 22209034), the Innovation and Entrepreneurship Project of Overseas
Returnees in Anhui Province (Grant No. 2022LCX002) and the Fundamental Research
Funds for the Central Universities (JZ2024HGTB0239). K.H.L. acknowledges financial
support from the National Natural Science Foundation of China (NSFC) (Grant No.
22208293). ICN2 acknowledges funding from Generalitat de Catalunya 2021SGR00457.
Authors acknowledge the Advanced Materials programme by the Spanish Government with
funding from European Union NextGenerationEU (PRTR-C17.I1) and by Generalitat de
Catalunya (Project In-CAEM). The authors thank support from the project AMaDE (PID2023-149158OB-C43),
funded by MCIN/AEI/10.13039/501100011033/and by “ERDF Away of making Europe”, by
the “European Union”. ICN2 is supported by the Severo Ochoa program from Spanish
MCIN/AEI (Grant No.: CEX2021-001214-S) and is funded by the CERCA Programme/Generalitat
de Catalunya. ICN2 is founding member of e-DREAM. (68) M.H. acknowledges the funding
from the Australian Research Council (FT230100316 and IH200100035). M.H. acknowledges
the computational support from the National Computational Infrastructure (NCI) and
Pawsey Supercomputing Centre, Australia.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Tobias
full_name: Kleinhanns, Tobias
id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
last_name: Kleinhanns
orcid: 0000-0003-1537-7436
- first_name: Sharona
full_name: Horta, Sharona
id: 03a7e858-01b1-11ec-8b71-99ae6c4a05bc
last_name: Horta
- first_name: Ewelina
full_name: Dutkiewicz, Ewelina
id: 0601cc46-c082-11ec-9b07-bb29641d1de9
last_name: Dutkiewicz
- first_name: Shaoqing
full_name: Lu, Shaoqing
last_name: Lu
- first_name: Maria Chiara
full_name: Spadaro, Maria Chiara
last_name: Spadaro
- first_name: Aziz
full_name: Genç, Aziz
last_name: Genç
- first_name: Lei
full_name: Chen, Lei
last_name: Chen
- first_name: Khak Ho
full_name: Lim, Khak Ho
last_name: Lim
- first_name: Min
full_name: Hong, Min
last_name: Hong
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
citation:
ama: Liu Y, Kleinhanns T, Horta S, et al. Liquid-solid interface reactions drive
enhanced thermoelectric performance in Ag2Se. Journal of the American Chemical
Society. 2025;147(35):32199-32208. doi:10.1021/jacs.5c11435
apa: Liu, Y., Kleinhanns, T., Horta, S., Dutkiewicz, E., Lu, S., Spadaro, M. C.,
… Ibáñez, M. (2025). Liquid-solid interface reactions drive enhanced thermoelectric
performance in Ag2Se. Journal of the American Chemical Society. American
Chemical Society. https://doi.org/10.1021/jacs.5c11435
chicago: Liu, Yu, Tobias Kleinhanns, Sharona Horta, Ewelina Dutkiewicz, Shaoqing
Lu, Maria Chiara Spadaro, Aziz Genç, et al. “Liquid-Solid Interface Reactions
Drive Enhanced Thermoelectric Performance in Ag2Se.” Journal of the American
Chemical Society. American Chemical Society, 2025. https://doi.org/10.1021/jacs.5c11435.
ieee: Y. Liu et al., “Liquid-solid interface reactions drive enhanced thermoelectric
performance in Ag2Se,” Journal of the American Chemical Society, vol. 147,
no. 35. American Chemical Society, pp. 32199–32208, 2025.
ista: Liu Y, Kleinhanns T, Horta S, Dutkiewicz E, Lu S, Spadaro MC, Genç A, Chen
L, Lim KH, Hong M, Arbiol J, Ibáñez M. 2025. Liquid-solid interface reactions
drive enhanced thermoelectric performance in Ag2Se. Journal of the American Chemical
Society. 147(35), 32199–32208.
mla: Liu, Yu, et al. “Liquid-Solid Interface Reactions Drive Enhanced Thermoelectric
Performance in Ag2Se.” Journal of the American Chemical Society, vol. 147,
no. 35, American Chemical Society, 2025, pp. 32199–208, doi:10.1021/jacs.5c11435.
short: Y. Liu, T. Kleinhanns, S. Horta, E. Dutkiewicz, S. Lu, M.C. Spadaro, A. Genç,
L. Chen, K.H. Lim, M. Hong, J. Arbiol, M. Ibáñez, Journal of the American Chemical
Society 147 (2025) 32199–32208.
corr_author: '1'
date_created: 2025-09-10T05:44:03Z
date_published: 2025-08-22T00:00:00Z
date_updated: 2026-07-28T09:55:14Z
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doi: 10.1021/jacs.5c11435
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publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Liquid-solid interface reactions drive enhanced thermoelectric performance
in Ag2Se
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
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abstract:
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text: Here, we present a foundational investigation of charge transport through
three BODIPY-based molecules using the scanning tunneling microscope–break junction
(STM-BJ) technique. We demonstrate that molecular conductance through the BODIPY
core can be measured by introducing aurophilic linkers at the 2,6-positions. By
varying these linkers, we systematically modulate the frontier molecular orbital
energies and fine-tune transport behavior. Our experimental results are supported
by DFT-based calculations, which feature a new computationally efficient correction
to standard PBE-level transmission predictions. Together, these findings establish
the viability of BODIPY-based systems for molecular junction applications and
lay the groundwork for future studies of their single-molecule optoelectronic
properties.
acknowledged_ssus:
- _id: LifeSc
- _id: MassSpec
acknowledgement: We thank the National Science Foundation (No. NSF-DMR 2241180) for
supporting this research. Synthetic work at Columbia was funded in part by the Air
Force Office of Scientific Research (AFOSR), under Grant No. FA9550-22-1-0389. The
cryoprobe on the 500 MHz NMR instrument used in this research at Columbia was purchased
through the NIH Award No. S10OD026749. This work was supported in part by the Institute
of Science and Technology Austria. HRMS sample preparation, analysis, and data evaluation
were performed by Aikaterina Paraskevopoulou, Mass Spec Service, LSF, ISTA.
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Emma
full_name: York, Emma
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last_name: York
- first_name: Ilana
full_name: Stone, Ilana
last_name: Stone
- first_name: Wanzhuo
full_name: Shi, Wanzhuo
id: a3010425-87c8-11f0-8106-bec32bea74da
last_name: Shi
- first_name: Xavier
full_name: Roy, Xavier
last_name: Roy
- first_name: Latha
full_name: Venkataraman, Latha
id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
last_name: Venkataraman
orcid: 0000-0002-6957-6089
citation:
ama: York E, Stone I, Shi W, Roy X, Venkataraman L. Tuning conductance in BODIPY-based
single-molecule junctions. Nano Letters. 2025;25(36):13697-13702. doi:10.1021/acs.nanolett.5c03764
apa: York, E., Stone, I., Shi, W., Roy, X., & Venkataraman, L. (2025). Tuning
conductance in BODIPY-based single-molecule junctions. Nano Letters. American
Chemical Society. https://doi.org/10.1021/acs.nanolett.5c03764
chicago: York, Emma, Ilana Stone, Wanzhuo Shi, Xavier Roy, and Latha Venkataraman.
“Tuning Conductance in BODIPY-Based Single-Molecule Junctions.” Nano Letters.
American Chemical Society, 2025. https://doi.org/10.1021/acs.nanolett.5c03764.
ieee: E. York, I. Stone, W. Shi, X. Roy, and L. Venkataraman, “Tuning conductance
in BODIPY-based single-molecule junctions,” Nano Letters, vol. 25, no.
36. American Chemical Society, pp. 13697–13702, 2025.
ista: York E, Stone I, Shi W, Roy X, Venkataraman L. 2025. Tuning conductance in
BODIPY-based single-molecule junctions. Nano Letters. 25(36), 13697–13702.
mla: York, Emma, et al. “Tuning Conductance in BODIPY-Based Single-Molecule Junctions.”
Nano Letters, vol. 25, no. 36, American Chemical Society, 2025, pp. 13697–702,
doi:10.1021/acs.nanolett.5c03764.
short: E. York, I. Stone, W. Shi, X. Roy, L. Venkataraman, Nano Letters 25 (2025)
13697–13702.
corr_author: '1'
das_tickbox: '1'
date_created: 2025-09-10T05:48:29Z
date_published: 2025-08-25T00:00:00Z
date_updated: 2026-07-28T09:53:54Z
day: '25'
ddc:
- '540'
department:
- _id: LaVe
doi: 10.1021/acs.nanolett.5c03764
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creator: dernst
date_created: 2025-12-30T09:39:44Z
date_updated: 2025-12-30T09:39:44Z
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file_name: 2025_NanoLetters_York.pdf
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file_date_updated: 2025-12-30T09:39:44Z
has_accepted_license: '1'
intvolume: ' 25'
isi: 1
issue: '36'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 13697-13702
pmid: 1
publication: Nano Letters
publication_identifier:
eissn:
- 1530-6992
issn:
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publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tuning conductance in BODIPY-based single-molecule junctions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2025'
...