[{"_id":"8168","volume":375,"publication":"Philosophical Transactions of the Royal Society. Series B: Biological sciences","citation":{"apa":"Kulmuni, J., Butlin, R. K., Lucek, K., Savolainen, V., &#38; Westram, A. M. (2020). Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0528\">https://doi.org/10.1098/rstb.2019.0528</a>","ama":"Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. <i>Philosophical Transactions of the Royal Society Series B: Biological sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0528\">10.1098/rstb.2019.0528</a>","chicago":"Kulmuni, Jonna, Roger K. Butlin, Kay Lucek, Vincent Savolainen, and Anja M Westram. “Towards the Completion of Speciation: The Evolution of Reproductive Isolation beyond the First Barriers.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0528\">https://doi.org/10.1098/rstb.2019.0528</a>.","mla":"Kulmuni, Jonna, et al. “Towards the Completion of Speciation: The Evolution of Reproductive Isolation beyond the First Barriers.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190528, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0528\">10.1098/rstb.2019.0528</a>.","ieee":"J. Kulmuni, R. K. Butlin, K. Lucek, V. Savolainen, and A. M. Westram, “Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers,” <i>Philosophical Transactions of the Royal Society. Series B: Biological sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.","short":"J. Kulmuni, R.K. Butlin, K. Lucek, V. Savolainen, A.M. Westram, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","ista":"Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. 2020. Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. Philosophical Transactions of the Royal Society. Series B: Biological sciences. 375(1806), 20190528."},"title":"Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers","oa":1,"scopus_import":"1","date_updated":"2026-06-18T19:30:51Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","main_file_link":[{"url":"https://doi.org/10.1098/rstb.2019.0528","open_access":"1"}],"language":[{"iso":"eng"}],"doi":"10.1098/rstb.2019.0528","ddc":["570"],"intvolume":"       375","isi":1,"pmid":1,"external_id":{"isi":["000552662100001"],"pmid":["32654637"]},"article_number":"20190528","issue":"1806","date_created":"2020-07-26T22:01:01Z","quality_controlled":"1","ec_funded":1,"fulldoi":"https://doi.org/10.1098/rstb.2019.0528","article_type":"original","author":[{"first_name":"Jonna","last_name":"Kulmuni","full_name":"Kulmuni, Jonna"},{"first_name":"Roger K.","last_name":"Butlin","full_name":"Butlin, Roger K."},{"first_name":"Kay","full_name":"Lucek, Kay","last_name":"Lucek"},{"first_name":"Vincent","last_name":"Savolainen","full_name":"Savolainen, Vincent"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","orcid":"0000-0003-1050-4969","last_name":"Westram","full_name":"Westram, Anja M"}],"department":[{"_id":"NiBa"}],"publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"oa_version":"Published Version","day":"12","type":"journal_article","publication_status":"published","date_published":"2020-07-12T00:00:00Z","status":"public","project":[{"name":"Theoretical and empirical approaches to understanding Parallel Adaptation","call_identifier":"H2020","_id":"265B41B8-B435-11E9-9278-68D0E5697425","grant_number":"797747"}],"abstract":[{"text":"Speciation, that is, the evolution of reproductive barriers eventually leading to complete isolation, is a crucial process generating biodiversity. Recent work has contributed much to our understanding of how reproductive barriers begin to evolve, and how they are maintained in the face of gene flow. However, little is known about the transition from partial to strong reproductive isolation (RI) and the completion of speciation. We argue that the evolution of strong RI is likely to involve different processes, or new interactions among processes, compared with the evolution of the first reproductive barriers. Transition to strong RI may be brought about by changing external conditions, for example, following secondary contact. However, the increasing levels of RI themselves create opportunities for new barriers to evolve and, and interaction or coupling among barriers. These changing processes may depend on genomic architecture and leave detectable signals in the genome. We outline outstanding questions and suggest more theoretical and empirical work, considering both patterns and processes associated with strong RI, is needed to understand how speciation is completed.","lang":"eng"}],"article_processing_charge":"No","year":"2020","publisher":"The Royal Society","month":"07"},{"external_id":{"isi":["000552662100013"],"pmid":["32654641"]},"pmid":1,"article_number":"20190544","issue":"1806","acknowledgement":"This work was supported by a fellowship from the China Scholarship Council (CSC) to H.S., Swiss National Science Foundation (SNF) grant no. 31003A_149306 to C.L., doctoral programme grant W1225-B20 to a faculty team including C.L., and the University of Vienna. We thank members of J.L.’s lab for collecting samples, Michael Barfuss and Elfi Grasserbauer for help in the laboratory, the Next Generation Sequencing Platform of the University of Berne for sequencing, the Vienna Scientific Cluster (VSC) for access to computational resources, and Claus Vogel and members of the PopGen Vienna graduate school for helpful discussions.","date_created":"2020-07-26T22:01:02Z","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1098/rstb.2019.0544","isi":1,"intvolume":"       375","title":"Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group","OA_type":"closed access","date_updated":"2026-04-03T09:31:37Z","scopus_import":"1","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","_id":"8169","volume":375,"publication":"Philosophical Transactions of the Royal Society. Series B: Biological Sciences","citation":{"mla":"Shang, Huiying, et al. “Evolution of Strong Reproductive Isolation in Plants: Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190544, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0544\">10.1098/rstb.2019.0544</a>.","ieee":"H. Shang <i>et al.</i>, “Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group,” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.","short":"H. Shang, J. Hess, M. Pickup, D. Field, P.K. Ingvarsson, J. Liu, C. Lexer, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","ista":"Shang H, Hess J, Pickup M, Field D, Ingvarsson PK, Liu J, Lexer C. 2020. Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. Philosophical Transactions of the Royal Society. Series B: Biological Sciences. 375(1806), 20190544.","apa":"Shang, H., Hess, J., Pickup, M., Field, D., Ingvarsson, P. K., Liu, J., &#38; Lexer, C. (2020). Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0544\">https://doi.org/10.1098/rstb.2019.0544</a>","ama":"Shang H, Hess J, Pickup M, et al. Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. <i>Philosophical Transactions of the Royal Society Series B: Biological Sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0544\">10.1098/rstb.2019.0544</a>","chicago":"Shang, Huiying, Jaqueline Hess, Melinda Pickup, David Field, Pär K. Ingvarsson, Jianquan Liu, and Christian Lexer. “Evolution of Strong Reproductive Isolation in Plants: Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0544\">https://doi.org/10.1098/rstb.2019.0544</a>."},"abstract":[{"text":"Many recent studies have addressed the mechanisms operating during the early stages of speciation, but surprisingly few studies have tested theoretical predictions on the evolution of strong reproductive isolation (RI). To help address this gap, we first undertook a quantitative review of the hybrid zone literature for flowering plants in relation to reproductive barriers. Then, using Populus as an exemplary model group, we analysed genome-wide variation for phylogenetic tree topologies in both early- and late-stage speciation taxa to determine how these patterns may be related to the genomic architecture of RI. Our plant literature survey revealed variation in barrier complexity and an association between barrier number and introgressive gene flow. Focusing on Populus, our genome-wide analysis of tree topologies in speciating poplar taxa points to unusually complex genomic architectures of RI, consistent with earlier genome-wide association studies. These architectures appear to facilitate the ‘escape’ of introgressed genome segments from polygenic barriers even with strong RI, thus affecting their relationships with recombination rates. Placed within the context of the broader literature, our data illustrate how phylogenomic approaches hold great promise for addressing the evolution and temporary breakdown of RI during late stages of speciation.","lang":"eng"}],"publisher":"The Royal Society","year":"2020","article_processing_charge":"No","month":"07","type":"journal_article","publication_status":"published","date_published":"2020-07-12T00:00:00Z","status":"public","publication_identifier":{"eissn":["1471-2970"]},"oa_version":"None","day":"12","fulldoi":"https://doi.org/10.1098/rstb.2019.0544","article_type":"original","department":[{"_id":"NiBa"}],"author":[{"last_name":"Shang","full_name":"Shang, Huiying","first_name":"Huiying"},{"full_name":"Hess, Jaqueline","last_name":"Hess","first_name":"Jaqueline"},{"orcid":"0000-0001-6118-0541","first_name":"Melinda","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","full_name":"Pickup, Melinda","last_name":"Pickup"},{"orcid":"0000-0002-4014-8478","first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","full_name":"Field, David","last_name":"Field"},{"first_name":"Pär K.","full_name":"Ingvarsson, Pär K.","last_name":"Ingvarsson"},{"first_name":"Jianquan","full_name":"Liu, Jianquan","last_name":"Liu"},{"first_name":"Christian","full_name":"Lexer, Christian","last_name":"Lexer"}]},{"file":[{"success":1,"creator":"dernst","checksum":"4f1382ed4384751b6013398c11557bf6","access_level":"open_access","date_created":"2020-08-18T08:03:23Z","date_updated":"2020-08-18T08:03:23Z","file_name":"Data_Rcode_MathematicaNB.zip","content_type":"application/x-zip-compressed","relation":"main_file","file_size":5778420,"file_id":"8280"}],"related_material":{"record":[{"status":"public","relation":"later_version","id":"9192"},{"status":"public","id":"11321","relation":"later_version"}]},"citation":{"apa":"Arathoon, L. S. (2020). Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus). Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8254\">https://doi.org/10.15479/AT:ISTA:8254</a>","ama":"Arathoon LS. Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus). 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8254\">10.15479/AT:ISTA:8254</a>","chicago":"Arathoon, Louise S. “Estimating Inbreeding and Its Effects in a Long-Term Study of Snapdragons (Antirrhinum Majus).” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8254\">https://doi.org/10.15479/AT:ISTA:8254</a>.","ieee":"L. S. Arathoon, “Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus).” Institute of Science and Technology Austria, 2020.","mla":"Arathoon, Louise S. <i>Estimating Inbreeding and Its Effects in a Long-Term Study of Snapdragons (Antirrhinum Majus)</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8254\">10.15479/AT:ISTA:8254</a>.","short":"L.S. Arathoon, (2020).","ista":"Arathoon LS. 2020. Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus), Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8254\">10.15479/AT:ISTA:8254</a>."},"author":[{"full_name":"Arathoon, Louise S","last_name":"Arathoon","orcid":"0000-0003-1771-714X","first_name":"Louise S","id":"2CFCFF98-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"NiBa"}],"_id":"8254","corr_author":"1","fulldoi":"https://doi.org/10.15479/AT:ISTA:8254","day":"18","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","oa":1,"title":"Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2024-10-09T21:02:14Z","oa_version":"Published Version","ddc":["576"],"date_published":"2020-08-18T00:00:00Z","status":"public","file_date_updated":"2020-08-18T08:03:23Z","doi":"10.15479/AT:ISTA:8254","type":"research_data","date_created":"2020-08-12T12:49:23Z","contributor":[{"id":"2CFCFF98-F248-11E8-B48F-1D18A9856A87","first_name":"Louise S","contributor_type":"data_collector","last_name":"Arathoon"},{"contributor_type":"project_member","last_name":"Surendranadh","id":"455235B8-F248-11E8-B48F-1D18A9856A87","first_name":"Parvathy"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","contributor_type":"project_member","last_name":"Barton"},{"contributor_type":"project_member","last_name":"Field","id":"419049E2-F248-11E8-B48F-1D18A9856A87","first_name":"David","orcid":"0000-0002-4014-8478"},{"orcid":"0000-0001-6118-0541","first_name":"Melinda","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","last_name":"Pickup","contributor_type":"project_member"},{"contributor_type":"project_member","last_name":"Baskett","id":"3B4A7CE2-F248-11E8-B48F-1D18A9856A87","first_name":"Carina"}],"month":"08","abstract":[{"lang":"eng","text":"Here are the research data underlying the publication \"Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)\". Further information are summed up in the README document.\r\nThe files for this record have been updated and are now found in the linked DOI https://doi.org/10.15479/AT:ISTA:9192."}],"year":"2020","article_processing_charge":"No","publisher":"Institute of Science and Technology Austria"},{"day":"20","has_accepted_license":"1","oa_version":"Published Version","publication_identifier":{"eissn":["2663-337X"]},"department":[{"_id":"NiBa"}],"author":[{"full_name":"Szep, Eniko","last_name":"Szep","first_name":"Eniko","id":"485BB5A4-F248-11E8-B48F-1D18A9856A87"}],"alternative_title":["ISTA Thesis"],"corr_author":"1","fulldoi":"https://doi.org/10.15479/AT:ISTA:8574","OA_place":"publisher","month":"09","year":"2020","article_processing_charge":"No","publisher":"Institute of Science and Technology Austria","abstract":[{"lang":"eng","text":"This thesis concerns itself with the interactions of evolutionary and ecological forces and the consequences on genetic diversity and the ultimate survival of populations. It is important to understand what signals processes \r\nleave on the genome and what we can infer from such data, which is usually abundant but noisy. Furthermore, understanding how and when populations adapt or go extinct is important for practical purposes,  such as the genetic management of populations, as well as for theoretical questions, since local adaptation can be the first step toward speciation. \r\nIn Chapter 2, we introduce the method of maximum entropy to approximate the demographic changes of a population in a simple setting, namely the logistic growth model with immigration. We show that this method is not only a powerful \r\ntool in physics but can be gainfully applied in an ecological framework. We investigate how well it approximates the real \r\nbehavior of the system, and find that is does so, even in unexpected situations. Finally, we illustrate how it can model changing environments.\r\nIn Chapter 3, we analyze the co-evolution of allele frequencies and population sizes in an infinite island model.\r\nWe give conditions under which polygenic adaptation to a rare habitat is possible. The model we use is based on the diffusion approximation, considers eco-evolutionary feedback mechanisms (hard selection), and treats both \r\ndrift and environmental fluctuations explicitly. We also look at limiting scenarios, for which we derive analytical expressions. \r\nIn Chapter 4, we present a coalescent based simulation tool to obtain patterns of diversity in a spatially explicit subdivided population, in which the demographic history of each subpopulation can be specified. We compare \r\nthe results to existing predictions, and explore the relative importance of time and space under a variety of spatial arrangements and demographic histories, such as expansion and extinction. \r\nIn the last chapter, we give a brief outlook to further research. "}],"supervisor":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H"}],"date_published":"2020-09-20T00:00:00Z","status":"public","publication_status":"published","type":"dissertation","file_date_updated":"2020-09-28T07:25:37Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-08T07:21:44Z","oa":1,"title":"Local adaptation in metapopulations","citation":{"apa":"Szep, E. (2020). <i>Local adaptation in metapopulations</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8574\">https://doi.org/10.15479/AT:ISTA:8574</a>","chicago":"Szep, Eniko. “Local Adaptation in Metapopulations.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8574\">https://doi.org/10.15479/AT:ISTA:8574</a>.","ama":"Szep E. Local adaptation in metapopulations. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8574\">10.15479/AT:ISTA:8574</a>","ieee":"E. Szep, “Local adaptation in metapopulations,” Institute of Science and Technology Austria, 2020.","mla":"Szep, Eniko. <i>Local Adaptation in Metapopulations</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8574\">10.15479/AT:ISTA:8574</a>.","ista":"Szep E. 2020. Local adaptation in metapopulations. Institute of Science and Technology Austria.","short":"E. Szep, Local Adaptation in Metapopulations, Institute of Science and Technology Austria, 2020."},"file":[{"access_level":"open_access","date_created":"2020-09-28T07:25:35Z","file_name":"thesis_EnikoSzep_final.pdf","relation":"main_file","content_type":"application/pdf","file_id":"8575","file_size":6354833,"date_updated":"2020-09-28T07:25:35Z","success":1,"checksum":"20e71f015fbbd78fea708893ad634ed0","creator":"dernst"},{"checksum":"a8de2c14a1bb4e53c857787efbb289e1","creator":"dernst","file_name":"thesisFiles_EnikoSzep.zip","content_type":"application/x-zip-compressed","relation":"source_file","file_size":23020401,"file_id":"8576","date_updated":"2020-09-28T07:25:37Z","access_level":"closed","date_created":"2020-09-28T07:25:37Z"}],"page":"158","_id":"8574","date_created":"2020-09-28T07:33:38Z","ddc":["570"],"degree_awarded":"PhD","doi":"10.15479/AT:ISTA:8574","language":[{"iso":"eng"}]},{"month":"07","date_created":"2020-11-25T11:07:25Z","publisher":"Dryad","article_processing_charge":"No","year":"2020","abstract":[{"text":"When divergent populations are connected by gene flow, the establishment of complete reproductive isolation usually requires the joint action of multiple barrier effects. One example where multiple barrier effects are coupled consists of a single trait that is under divergent natural selection and also mediates assortative mating. Such multiple-effect traits can strongly reduce gene flow. However, there are few cases where patterns of assortative mating have been described quantitatively and their impact on gene flow has been determined. Two ecotypes of the coastal marine snail, Littorina saxatilis, occur in North Atlantic rocky-shore habitats dominated by either crab predation or wave action. There is evidence for divergent natural selection acting on size, and size-assortative mating has previously been documented. Here, we analyze the mating pattern in L. saxatilis with respect to size in intensively-sampled transects across boundaries between the habitats. We show that the mating pattern is mostly conserved between ecotypes and that it generates both assortment and directional sexual selection for small male size. Using simulations, we show that the mating pattern can contribute to reproductive isolation between ecotypes but the barrier to gene flow is likely strengthened more by sexual selection than by assortment.","lang":"eng"}],"date_published":"2020-07-01T00:00:00Z","status":"public","type":"research_data_reference","doi":"10.5061/dryad.qrfj6q5cn","main_file_link":[{"url":"https://doi.org/10.5061/dryad.qrfj6q5cn","open_access":"1"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","has_accepted_license":"1","day":"01","tmp":{"image":"/images/cc_0.png","short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode"},"date_updated":"2025-07-10T11:54:59Z","oa_version":"Published Version","license":"https://creativecommons.org/publicdomain/zero/1.0/","oa":1,"title":"Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina","author":[{"full_name":"Perini, Samuel","last_name":"Perini","first_name":"Samuel"},{"first_name":"Marina","full_name":"Rafajlovic, Marina","last_name":"Rafajlovic"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","orcid":"0000-0003-1050-4969","last_name":"Westram","full_name":"Westram, Anja M"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"full_name":"Butlin, Roger","last_name":"Butlin","first_name":"Roger"}],"department":[{"_id":"NiBa"}],"related_material":{"record":[{"id":"7995","relation":"used_in_publication","status":"public"}]},"citation":{"apa":"Perini, S., Rafajlovic, M., Westram, A. M., Johannesson, K., &#38; Butlin, R. (2020). Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina. Dryad. <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">https://doi.org/10.5061/dryad.qrfj6q5cn</a>","ama":"Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina. 2020. doi:<a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>","chicago":"Perini, Samuel, Marina Rafajlovic, Anja M Westram, Kerstin Johannesson, and Roger Butlin. “Data from: Assortative Mating, Sexual Selection and Their Consequences for Gene Flow in Littorina.” Dryad, 2020. <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">https://doi.org/10.5061/dryad.qrfj6q5cn</a>.","mla":"Perini, Samuel, et al. <i>Data from: Assortative Mating, Sexual Selection and Their Consequences for Gene Flow in Littorina</i>. Dryad, 2020, doi:<a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>.","ieee":"S. Perini, M. Rafajlovic, A. M. Westram, K. Johannesson, and R. Butlin, “Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina.” Dryad, 2020.","short":"S. Perini, M. Rafajlovic, A.M. Westram, K. Johannesson, R. Butlin, (2020).","ista":"Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. 2020. Data from: Assortative mating, sexual selection and their consequences for gene flow in Littorina, Dryad, <a href=\"https://doi.org/10.5061/dryad.qrfj6q5cn\">10.5061/dryad.qrfj6q5cn</a>."},"fulldoi":"https://doi.org/10.5061/dryad.qrfj6q5cn","_id":"8809"},{"citation":{"apa":"Westram, A. M., Faria, R., Butlin, R., &#38; Johannesson, K. (2020). Inversions and Evolution. In <i>eLS</i>. Wiley. <a href=\"https://doi.org/10.1002/9780470015902.a0029007\">https://doi.org/10.1002/9780470015902.a0029007</a>","ama":"Westram AM, Faria R, Butlin R, Johannesson K. Inversions and Evolution. In: <i>ELS</i>. Wiley; 2020. doi:<a href=\"https://doi.org/10.1002/9780470015902.a0029007\">10.1002/9780470015902.a0029007</a>","chicago":"Westram, Anja M, Rui Faria, Roger Butlin, and Kerstin Johannesson. “Inversions and Evolution.” In <i>ELS</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/9780470015902.a0029007\">https://doi.org/10.1002/9780470015902.a0029007</a>.","ieee":"A. M. Westram, R. Faria, R. Butlin, and K. Johannesson, “Inversions and Evolution,” in <i>eLS</i>, Wiley, 2020.","mla":"Westram, Anja M., et al. “Inversions and Evolution.” <i>ELS</i>, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/9780470015902.a0029007\">10.1002/9780470015902.a0029007</a>.","short":"A.M. Westram, R. Faria, R. Butlin, K. Johannesson, in:, ELS, Wiley, 2020.","ista":"Westram AM, Faria R, Butlin R, Johannesson K. 2020.Inversions and Evolution. In: eLS. ."},"department":[{"_id":"NiBa"}],"author":[{"last_name":"Westram","full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969","first_name":"Anja M"},{"last_name":"Faria","full_name":"Faria, Rui","first_name":"Rui"},{"first_name":"Roger","last_name":"Butlin","full_name":"Butlin, Roger"},{"last_name":"Johannesson","full_name":"Johannesson, Kerstin","first_name":"Kerstin"}],"publication":"eLS","fulldoi":"https://doi.org/10.1002/9780470015902.a0029007","_id":"9123","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","day":"16","date_updated":"2026-04-16T10:25:26Z","oa_version":"None","publication_identifier":{"eissn":["9780470015902"],"isbn":["9780470016176"]},"title":"Inversions and Evolution","date_published":"2020-05-16T00:00:00Z","status":"public","publication_status":"published","doi":"10.1002/9780470015902.a0029007","type":"book_chapter","language":[{"iso":"eng"}],"quality_controlled":"1","month":"05","date_created":"2021-02-15T12:39:04Z","year":"2020","article_processing_charge":"No","publisher":"Wiley","abstract":[{"text":"Inversions are chromosomal rearrangements where the order of genes is reversed. Inversions originate by mutation and can be under positive, negative or balancing selection. Selective effects result from potential disruptive effects on meiosis, gene disruption at inversion breakpoints and, importantly, the effects of inversions as modifiers of recombination rate: Recombination is strongly reduced in individuals heterozygous for an inversion, allowing for alleles at different loci to be inherited as a ‘block’. This may lead to a selective advantage whenever it is favourable to keep certain combinations of alleles associated, for example under local adaptation with gene flow. Inversions can cover a considerable part of a chromosome and contain numerous loci under different selection pressures, so that the resulting overall effects may be complex. Empirical data from various systems show that inversions may have a prominent role in local adaptation, speciation, parallel evolution, the maintenance of polymorphism and sex chromosome evolution.","lang":"eng"}]},{"month":"10","date_created":"2021-08-06T11:18:15Z","publisher":"Royal Society of London","article_processing_charge":"No","year":"2020","abstract":[{"lang":"eng","text":"Fitness interactions between mutations can influence a population’s evolution in many different ways. While epistatic effects are difficult to measure precisely, important information is captured by the mean and variance of log fitnesses for individuals carrying different numbers of mutations. We derive predictions for these quantities from a class of simple fitness landscapes, based on models of optimizing selection on quantitative traits. We also explore extensions to the models, including modular pleiotropy, variable effect sizes, mutational bias and maladaptation of the wild type. We illustrate our approach by reanalysing a large dataset of mutant effects in a yeast snoRNA. Though characterized by some large epistatic effects, these data give a good overall fit to the non-epistatic null model, suggesting that epistasis might have limited influence on the evolutionary dynamics in this system. We also show how the amount of epistasis depends on both the underlying fitness landscape and the distribution of mutations, and so is expected to vary in consistent ways between new mutations, standing variation and fixed mutations."}],"status":"public","date_published":"2020-10-15T00:00:00Z","type":"research_data_reference","doi":"10.6084/m9.figshare.7957472.v1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.6084/m9.figshare.7957472.v1"}],"user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","day":"15","date_updated":"2026-06-18T19:05:02Z","oa_version":"Published Version","OA_type":"hybrid","title":"Simulation code for Fig S2 from the distribution of epistasis on simple fitness landscapes","oa":1,"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"author":[{"first_name":"Christelle","orcid":"0000-0001-8441-5075","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","full_name":"Fraisse, Christelle","last_name":"Fraisse"},{"full_name":"Welch, John J.","last_name":"Welch","first_name":"John J."}],"related_material":{"record":[{"id":"6467","relation":"used_in_publication","status":"public"}]},"citation":{"apa":"Fraisse, C., &#38; Welch, J. J. (2020). Simulation code for Fig S2 from the distribution of epistasis on simple fitness landscapes. Royal Society of London. <a href=\"https://doi.org/10.6084/m9.figshare.7957472.v1\">https://doi.org/10.6084/m9.figshare.7957472.v1</a>","ama":"Fraisse C, Welch JJ. Simulation code for Fig S2 from the distribution of epistasis on simple fitness landscapes. 2020. doi:<a href=\"https://doi.org/10.6084/m9.figshare.7957472.v1\">10.6084/m9.figshare.7957472.v1</a>","chicago":"Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S2 from the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of London, 2020. <a href=\"https://doi.org/10.6084/m9.figshare.7957472.v1\">https://doi.org/10.6084/m9.figshare.7957472.v1</a>.","ieee":"C. Fraisse and J. J. Welch, “Simulation code for Fig S2 from the distribution of epistasis on simple fitness landscapes.” Royal Society of London, 2020.","mla":"Fraisse, Christelle, and John J. Welch. <i>Simulation Code for Fig S2 from the Distribution of Epistasis on Simple Fitness Landscapes</i>. Royal Society of London, 2020, doi:<a href=\"https://doi.org/10.6084/m9.figshare.7957472.v1\">10.6084/m9.figshare.7957472.v1</a>.","short":"C. Fraisse, J.J. Welch, (2020).","ista":"Fraisse C, Welch JJ. 2020. Simulation code for Fig S2 from the distribution of epistasis on simple fitness landscapes, Royal Society of London, <a href=\"https://doi.org/10.6084/m9.figshare.7957472.v1\">10.6084/m9.figshare.7957472.v1</a>."},"fulldoi":"https://doi.org/10.6084/m9.figshare.7957472.v1","_id":"9798","OA_place":"publisher"},{"date_created":"2021-08-06T11:26:57Z","month":"10","abstract":[{"lang":"eng","text":"Fitness interactions between mutations can influence a population’s evolution in many different ways. While epistatic effects are difficult to measure precisely, important information is captured by the mean and variance of log fitnesses for individuals carrying different numbers of mutations. We derive predictions for these quantities from a class of simple fitness landscapes, based on models of optimizing selection on quantitative traits. We also explore extensions to the models, including modular pleiotropy, variable effect sizes, mutational bias and maladaptation of the wild type. We illustrate our approach by reanalysing a large dataset of mutant effects in a yeast snoRNA. Though characterized by some large epistatic effects, these data give a good overall fit to the non-epistatic null model, suggesting that epistasis might have limited influence on the evolutionary dynamics in this system. We also show how the amount of epistasis depends on both the underlying fitness landscape and the distribution of mutations, and so is expected to vary in consistent ways between new mutations, standing variation and fixed mutations."}],"year":"2020","article_processing_charge":"No","publisher":"Royal Society of London","date_published":"2020-10-15T00:00:00Z","status":"public","doi":"10.6084/m9.figshare.7957469.v1","type":"research_data_reference","day":"15","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","main_file_link":[{"open_access":"1","url":"https://doi.org/10.6084/m9.figshare.7957469.v1"}],"title":"Simulation code for Fig S1 from the distribution of epistasis on simple fitness landscapes","oa":1,"OA_type":"hybrid","oa_version":"Published Version","date_updated":"2026-06-18T19:05:02Z","related_material":{"record":[{"status":"public","id":"6467","relation":"used_in_publication"}]},"citation":{"ieee":"C. Fraisse and J. J. Welch, “Simulation code for Fig S1 from the distribution of epistasis on simple fitness landscapes.” Royal Society of London, 2020.","mla":"Fraisse, Christelle, and John J. Welch. <i>Simulation Code for Fig S1 from the Distribution of Epistasis on Simple Fitness Landscapes</i>. Royal Society of London, 2020, doi:<a href=\"https://doi.org/10.6084/m9.figshare.7957469.v1\">10.6084/m9.figshare.7957469.v1</a>.","ista":"Fraisse C, Welch JJ. 2020. Simulation code for Fig S1 from the distribution of epistasis on simple fitness landscapes, Royal Society of London, <a href=\"https://doi.org/10.6084/m9.figshare.7957469.v1\">10.6084/m9.figshare.7957469.v1</a>.","short":"C. Fraisse, J.J. Welch, (2020).","apa":"Fraisse, C., &#38; Welch, J. J. (2020). Simulation code for Fig S1 from the distribution of epistasis on simple fitness landscapes. Royal Society of London. <a href=\"https://doi.org/10.6084/m9.figshare.7957469.v1\">https://doi.org/10.6084/m9.figshare.7957469.v1</a>","chicago":"Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S1 from the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of London, 2020. <a href=\"https://doi.org/10.6084/m9.figshare.7957469.v1\">https://doi.org/10.6084/m9.figshare.7957469.v1</a>.","ama":"Fraisse C, Welch JJ. Simulation code for Fig S1 from the distribution of epistasis on simple fitness landscapes. 2020. doi:<a href=\"https://doi.org/10.6084/m9.figshare.7957469.v1\">10.6084/m9.figshare.7957469.v1</a>"},"author":[{"id":"32DF5794-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8441-5075","first_name":"Christelle","last_name":"Fraisse","full_name":"Fraisse, Christelle"},{"full_name":"Welch, John J.","last_name":"Welch","first_name":"John J."}],"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"OA_place":"publisher","_id":"9799","fulldoi":"https://doi.org/10.6084/m9.figshare.7957469.v1"},{"month":"03","abstract":[{"lang":"eng","text":"Genetic incompatibilities contribute to reproductive isolation between many diverging populations, but it is still unclear to what extent they play a role if divergence happens with gene flow. In contact zones between the \"Crab\" and \"Wave\" ecotypes of the snail Littorina saxatilis, divergent selection forms strong barriers to gene flow, while the role of post‐zygotic barriers due to selection against hybrids remains unclear. High embryo abortion rates in this species could indicate the presence of such barriers. Post‐zygotic barriers might include genetic incompatibilities (e.g. Dobzhansky–Muller incompatibilities) but also maladaptation, both expected to be most pronounced in contact zones. In addition, embryo abortion might reflect physiological stress on females and embryos independent of any genetic stress. We examined all embryos of >500 females sampled outside and inside contact zones of three populations in Sweden. Females' clutch size ranged from 0 to 1,011 embryos (mean 130 ± 123), and abortion rates varied between 0% and 100% (mean 12%). We described female genotypes by using a hybrid index based on hundreds of SNPs differentiated between ecotypes with which we characterized female genotypes. We also calculated female SNP heterozygosity and inversion karyotype. Clutch size did not vary with female hybrid index, and abortion rates were only weakly related to hybrid index in two sites but not at all in a third site. No additional variation in abortion rate was explained by female SNP heterozygosity, but increased female inversion heterozygosity added slightly to increased abortion. Our results show only weak and probably biologically insignificant post‐zygotic barriers contributing to ecotype divergence, and the high and variable abortion rates were marginally, if at all, explained by hybrid index of females."}],"article_processing_charge":"No","year":"2020","publisher":"Wiley","publication_status":"published","date_published":"2020-03-01T00:00:00Z","status":"public","file_date_updated":"2020-09-22T09:42:18Z","type":"journal_article","has_accepted_license":"1","day":"01","publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_type":"original","related_material":{"record":[{"status":"public","relation":"research_data","id":"13067"}]},"department":[{"_id":"NiBa"}],"author":[{"last_name":"Johannesson","full_name":"Johannesson, Kerstin","first_name":"Kerstin"},{"full_name":"Zagrodzka, Zuzanna","last_name":"Zagrodzka","first_name":"Zuzanna"},{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"full_name":"Westram, Anja M","last_name":"Westram","orcid":"0000-0003-1050-4969","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Butlin","full_name":"Butlin, Roger K.","first_name":"Roger K."}],"fulldoi":"https://doi.org/10.1111/jeb.13570","date_created":"2019-12-22T23:00:43Z","quality_controlled":"1","pmid":1,"external_id":{"pmid":["31724256"],"isi":["000500954800001"]},"issue":"3","ddc":["570"],"intvolume":"        33","isi":1,"language":[{"iso":"eng"}],"doi":"10.1111/jeb.13570","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?","oa":1,"scopus_import":"1","date_updated":"2025-07-10T11:54:22Z","publication":"Journal of Evolutionary Biology","citation":{"ama":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes? <i>Journal of Evolutionary Biology</i>. 2020;33(3):342-351. doi:<a href=\"https://doi.org/10.1111/jeb.13570\">10.1111/jeb.13570</a>","chicago":"Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and Roger K. Butlin. “Is Embryo Abortion a Post-Zygotic Barrier to Gene Flow between Littorina Ecotypes?” <i>Journal of Evolutionary Biology</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/jeb.13570\">https://doi.org/10.1111/jeb.13570</a>.","apa":"Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., &#38; Butlin, R. K. (2020). Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes? <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.13570\">https://doi.org/10.1111/jeb.13570</a>","short":"K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R.K. Butlin, Journal of Evolutionary Biology 33 (2020) 342–351.","ista":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. 2020. Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes? Journal of Evolutionary Biology. 33(3), 342–351.","mla":"Johannesson, Kerstin, et al. “Is Embryo Abortion a Post-Zygotic Barrier to Gene Flow between Littorina Ecotypes?” <i>Journal of Evolutionary Biology</i>, vol. 33, no. 3, Wiley, 2020, pp. 342–51, doi:<a href=\"https://doi.org/10.1111/jeb.13570\">10.1111/jeb.13570</a>.","ieee":"K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. K. Butlin, “Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?,” <i>Journal of Evolutionary Biology</i>, vol. 33, no. 3. Wiley, pp. 342–351, 2020."},"file":[{"access_level":"open_access","date_created":"2020-09-22T09:42:18Z","date_updated":"2020-09-22T09:42:18Z","file_name":"2020_EvolBiology_Johannesson.pdf","relation":"main_file","content_type":"application/pdf","file_size":885611,"file_id":"8553","success":1,"creator":"dernst","checksum":"7534ff0839709c0c5265c12d29432f03"}],"volume":33,"_id":"7205","page":"342-351"},{"language":[{"iso":"eng"}],"doi":"10.1002/ecm.1397","ddc":["570"],"intvolume":"        90","isi":1,"external_id":{"isi":["000508511600001"]},"issue":"1","article_number":"e01397","date_created":"2020-01-07T12:47:07Z","quality_controlled":"1","_id":"7236","volume":90,"publication":"Ecological Monographs","file":[{"checksum":"ab8130c6e68101f5a091d05324c36f08","creator":"dernst","file_id":"7469","file_size":537941,"content_type":"application/pdf","file_name":"2020_EcologMono_Baskett.pdf","relation":"main_file","date_updated":"2020-07-14T12:47:54Z","date_created":"2020-02-10T08:18:14Z","access_level":"open_access"}],"citation":{"apa":"Baskett, C., Schroeder, L., Weber, M. G., &#38; Schemske, D. W. (2020). Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. <i>Ecological Monographs</i>. Wiley. <a href=\"https://doi.org/10.1002/ecm.1397\">https://doi.org/10.1002/ecm.1397</a>","chicago":"Baskett, Carina, Lucy Schroeder, Marjorie G. Weber, and Douglas W. Schemske. “Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory for a Tropical‐temperate Congener Pair.” <i>Ecological Monographs</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/ecm.1397\">https://doi.org/10.1002/ecm.1397</a>.","ama":"Baskett C, Schroeder L, Weber MG, Schemske DW. Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. <i>Ecological Monographs</i>. 2020;90(1). doi:<a href=\"https://doi.org/10.1002/ecm.1397\">10.1002/ecm.1397</a>","ieee":"C. Baskett, L. Schroeder, M. G. Weber, and D. W. Schemske, “Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair,” <i>Ecological Monographs</i>, vol. 90, no. 1. Wiley, 2020.","mla":"Baskett, Carina, et al. “Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory for a Tropical‐temperate Congener Pair.” <i>Ecological Monographs</i>, vol. 90, no. 1, e01397, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/ecm.1397\">10.1002/ecm.1397</a>.","ista":"Baskett C, Schroeder L, Weber MG, Schemske DW. 2020. Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. Ecological Monographs. 90(1), e01397.","short":"C. Baskett, L. Schroeder, M.G. Weber, D.W. Schemske, Ecological Monographs 90 (2020)."},"title":"Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair","oa":1,"OA_type":"hybrid","scopus_import":"1","date_updated":"2025-04-14T07:44:07Z","user_id":"0043cee0-e5fc-11ee-9736-f83bc23afbf0","file_date_updated":"2020-07-14T12:47:54Z","type":"journal_article","publication_status":"published","date_published":"2020-02-01T00:00:00Z","status":"public","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"abstract":[{"lang":"eng","text":"The biotic interactions hypothesis posits that biotic interactions are more important drivers of adaptation closer to the equator, evidenced by “stronger” contemporary interactions (e.g. greater interaction rates) and/or patterns of trait evolution consistent with a history of stronger interactions. Support for the hypothesis is mixed, but few studies span tropical and temperate regions while experimentally controlling for evolutionary history. Here, we integrate field observations and common garden experiments to quantify the relative importance of pollination and herbivory in a pair of tropical‐temperate congeneric perennial herbs. Phytolacca rivinoides and P. americana are pioneer species native to the Neotropics and the eastern USA, respectively. We compared plant‐pollinator and plant‐herbivore interactions between three tropical populations of P. rivinoides from Costa Rica and three temperate populations of P. americana from its northern range edge in Michigan and Ohio. For some metrics of interaction importance, we also included three subtropical populations of P. americana from its southern range edge in Florida. This approach confounds species and region but allows us, uniquely, to measure complementary proxies of interaction importance across a tropical‐temperate range in one system. To test the prediction that lower‐latitude plants are more reliant on insect pollinators, we quantified floral display and reward, insect visitation rates, and self‐pollination ability (autogamy). To test the prediction that lower‐latitude plants experience more herbivore pressure, we quantified herbivory rates, herbivore abundance, and leaf palatability. We found evidence supporting the biotic interactions hypothesis for most comparisons between P. rivinoides and north‐temperate P. americana (floral display, insect visitation, autogamy, herbivory, herbivore abundance, and young‐leaf palatability). Results for subtropical P. americana populations, however, were typically not intermediate between P. rivinoides and north‐temperate P. americana, as would be predicted by a linear latitudinal gradient in interaction importance. Subtropical young‐leaf palatability was intermediate, but subtropical mature leaves were the least palatable, and pollination‐related traits did not differ between temperate and subtropical regions. These nonlinear patterns of interaction importance suggest future work to relate interaction importance to climatic or biotic thresholds. In sum, we found that the biotic interactions hypothesis was more consistently supported at the larger spatial scale of our study."}],"article_processing_charge":"Yes (via OA deal)","year":"2020","publisher":"Wiley","month":"02","ec_funded":1,"OA_place":"publisher","fulldoi":"https://doi.org/10.1002/ecm.1397","article_type":"original","author":[{"full_name":"Baskett, Carina","last_name":"Baskett","orcid":"0000-0002-7354-8574","first_name":"Carina","id":"3B4A7CE2-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lucy","full_name":"Schroeder, Lucy","last_name":"Schroeder"},{"first_name":"Marjorie G.","last_name":"Weber","full_name":"Weber, Marjorie G."},{"first_name":"Douglas W.","last_name":"Schemske","full_name":"Schemske, Douglas W."}],"department":[{"_id":"NiBa"}],"publication_identifier":{"issn":["0012-9615"],"eissn":["1557-7015"]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"day":"01","has_accepted_license":"1"},{"publication_identifier":{"eissn":["1742-5662"],"issn":["1742-5689"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","day":"01","has_accepted_license":"1","fulldoi":"https://doi.org/10.1098/rsif.2019.0721","article_type":"original","author":[{"last_name":"Larsson","full_name":"Larsson, J.","first_name":"J."},{"last_name":"Westram","full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","orcid":"0000-0003-1050-4969"},{"first_name":"S.","last_name":"Bengmark","full_name":"Bengmark, S."},{"full_name":"Lundh, T.","last_name":"Lundh","first_name":"T."},{"first_name":"R. K.","full_name":"Butlin, R. K.","last_name":"Butlin"}],"department":[{"_id":"NiBa"}],"abstract":[{"text":"The growth of snail shells can be described by simple mathematical rules. Variation in a few parameters can explain much of the diversity of shell shapes seen in nature. However, empirical studies of gastropod shell shape variation typically use geometric morphometric approaches, which do not capture this growth pattern. We have developed a way to infer a set of developmentally descriptive shape parameters based on three-dimensional logarithmic helicospiral growth and using landmarks from two-dimensional shell images as input. We demonstrate the utility of this approach, and compare it to the geometric morphometric approach, using a large set of Littorina saxatilis shells in which locally adapted populations differ in shape. Our method can be modified easily to make it applicable to a wide range of shell forms, which would allow for investigations of the similarities and differences between and within many different species of gastropods.","lang":"eng"}],"year":"2020","article_processing_charge":"No","publisher":"Royal Society","month":"02","file_date_updated":"2020-07-14T12:48:01Z","type":"journal_article","publication_status":"published","date_published":"2020-02-01T00:00:00Z","status":"public","oa":1,"title":"A developmentally descriptive method for quantifying shape in gastropod shells","scopus_import":"1","date_updated":"2026-08-12T14:06:19Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"7651","volume":17,"publication":"Journal of the Royal Society Interface","file":[{"creator":"dernst","checksum":"4eb102304402f5c56432516b84df86d6","access_level":"open_access","date_created":"2020-04-14T12:31:16Z","date_updated":"2020-07-14T12:48:01Z","relation":"main_file","content_type":"application/pdf","file_name":"2020_JournRoyalSociety_Larsson.pdf","file_id":"7660","file_size":1556190}],"citation":{"ama":"Larsson J, Westram AM, Bengmark S, Lundh T, Butlin RK. A developmentally descriptive method for quantifying shape in gastropod shells. <i>Journal of the Royal Society Interface</i>. 2020;17(163). doi:<a href=\"https://doi.org/10.1098/rsif.2019.0721\">10.1098/rsif.2019.0721</a>","chicago":"Larsson, J., Anja M Westram, S. Bengmark, T. Lundh, and R. K. Butlin. “A Developmentally Descriptive Method for Quantifying Shape in Gastropod Shells.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2020. <a href=\"https://doi.org/10.1098/rsif.2019.0721\">https://doi.org/10.1098/rsif.2019.0721</a>.","apa":"Larsson, J., Westram, A. M., Bengmark, S., Lundh, T., &#38; Butlin, R. K. (2020). A developmentally descriptive method for quantifying shape in gastropod shells. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2019.0721\">https://doi.org/10.1098/rsif.2019.0721</a>","short":"J. Larsson, A.M. Westram, S. Bengmark, T. Lundh, R.K. Butlin, Journal of the Royal Society Interface 17 (2020).","ista":"Larsson J, Westram AM, Bengmark S, Lundh T, Butlin RK. 2020. A developmentally descriptive method for quantifying shape in gastropod shells. Journal of the Royal Society Interface. 17(163), 20190721.","mla":"Larsson, J., et al. “A Developmentally Descriptive Method for Quantifying Shape in Gastropod Shells.” <i>Journal of the Royal Society Interface</i>, vol. 17, no. 163, 20190721, Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rsif.2019.0721\">10.1098/rsif.2019.0721</a>.","ieee":"J. Larsson, A. M. Westram, S. Bengmark, T. Lundh, and R. K. Butlin, “A developmentally descriptive method for quantifying shape in gastropod shells,” <i>Journal of the Royal Society Interface</i>, vol. 17, no. 163. Royal Society, 2020."},"issue":"163","article_number":"20190721","date_created":"2020-04-08T15:19:17Z","quality_controlled":"1","language":[{"iso":"eng"}],"doi":"10.1098/rsif.2019.0721","ddc":["570"],"intvolume":"        17"},{"citation":{"ieee":"K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. Butlin, “Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?” Dryad, 2019.","mla":"Johannesson, Kerstin, et al. <i>Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow between Littorina Ecotypes?</i> Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>.","ista":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. 2019. Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>.","short":"K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R. Butlin, (2019).","apa":"Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., &#38; Butlin, R. (2019). Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes? Dryad. <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">https://doi.org/10.5061/DRYAD.TB2RBNZWK</a>","chicago":"Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and Roger Butlin. “Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow between Littorina Ecotypes?” Dryad, 2019. <a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">https://doi.org/10.5061/DRYAD.TB2RBNZWK</a>.","ama":"Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes? 2019. doi:<a href=\"https://doi.org/10.5061/DRYAD.TB2RBNZWK\">10.5061/DRYAD.TB2RBNZWK</a>"},"related_material":{"record":[{"id":"7205","relation":"used_in_publication","status":"public"}]},"author":[{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"first_name":"Zuzanna","last_name":"Zagrodzka","full_name":"Zagrodzka, Zuzanna"},{"first_name":"Rui","full_name":"Faria, Rui","last_name":"Faria"},{"last_name":"Westram","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roger","full_name":"Butlin, Roger","last_name":"Butlin"}],"department":[{"_id":"NiBa"}],"fulldoi":"https://doi.org/10.5061/DRYAD.TB2RBNZWK","_id":"13067","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.tb2rbnzwk"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"02","tmp":{"image":"/images/cc_0.png","short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode"},"date_updated":"2025-07-10T11:54:22Z","oa_version":"Published Version","oa":1,"title":"Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?","date_published":"2019-12-02T00:00:00Z","status":"public","ddc":["570"],"doi":"10.5061/DRYAD.TB2RBNZWK","type":"research_data_reference","month":"12","date_created":"2023-05-23T16:36:27Z","article_processing_charge":"No","year":"2019","publisher":"Dryad","abstract":[{"text":"Genetic incompatibilities contribute to reproductive isolation between many diverging populations, but it is still unclear to what extent they play a role if divergence happens with gene flow. In contact zones between the \"Crab\" and \"Wave\" ecotypes of the snail Littorina saxatilis divergent selection forms strong barriers to gene flow, while the role of postzygotic barriers due to selection against hybrids remains unclear. High embryo abortion rates in this species could indicate the presence of such barriers. Postzygotic barriers might include genetic incompatibilities (e.g. Dobzhansky-Muller incompatibilities) but also maladaptation, both expected to be most pronounced in contact zones. In addition, embryo abortion might reflect physiological stress on females and embryos independent of any genetic stress. We examined all embryos of &gt;500 females sampled outside and inside contact zones of three populations in Sweden. Females' clutch size ranged from 0 to 1011 embryos (mean 130±123) and abortion rates varied between 0 and100% (mean 12%). We described female genotypes by using a hybrid index based on hundreds of SNPs differentiated between ecotypes with which we characterised female genotypes. We also calculated female SNP heterozygosity and inversion karyotype. Clutch size did not vary with female hybrid index and abortion rates were only weakly related to hybrid index in two sites but not at all in a third site. No additional variation in abortion rate was explained by female SNP heterozygosity, but increased female inversion heterozygosity added slightly to increased abortion. Our results show only weak and probably biologically insignificant postzygotic barriers contributing to ecotype divergence and the high and variable abortion rates were marginally, if at all, explained by hybrid index of females.","lang":"eng"}]},{"article_type":"original","author":[{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"last_name":"Johannesson","full_name":"Johannesson, Kerstin","first_name":"Kerstin"},{"first_name":"Roger K.","last_name":"Butlin","full_name":"Butlin, Roger K."},{"first_name":"Anja M","orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","last_name":"Westram"}],"department":[{"_id":"NiBa"}],"ec_funded":1,"fulldoi":"https://doi.org/10.1016/j.tree.2018.12.005","day":"01","has_accepted_license":"1","publication_identifier":{"issn":["0169-5347"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"oa_version":"Published Version","publication_status":"published","status":"public","date_published":"2019-03-01T00:00:00Z","file_date_updated":"2020-07-14T12:47:13Z","type":"journal_article","month":"03","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"abstract":[{"text":"Empirical data suggest that inversions in many species contain genes important for intraspecific divergence and speciation, yet mechanisms of evolution remain unclear. While genes inside an inversion are tightly linked, inversions are not static but evolve separately from the rest of the genome by new mutations, recombination within arrangements, and gene flux between arrangements. Inversion polymorphisms are maintained by different processes, for example, divergent or balancing selection, or a mix of multiple processes. Moreover, the relative roles of selection, drift, mutation, and recombination will change over the lifetime of an inversion and within its area of distribution. We believe inversions are central to the evolution of many species, but we need many more data and new models to understand the complex mechanisms involved.","lang":"eng"}],"article_processing_charge":"No","year":"2019","publisher":"Elsevier","publication":"Trends in Ecology and Evolution","file":[{"date_created":"2020-01-09T10:55:58Z","access_level":"open_access","date_updated":"2020-07-14T12:47:13Z","file_id":"7245","file_size":1946795,"relation":"main_file","file_name":"2019_Trends_Evolution_Faria.pdf","content_type":"application/pdf","creator":"cziletti","checksum":"ef24572d6ebcc1452c067e05410cc4a2"}],"citation":{"apa":"Faria, R., Johannesson, K., Butlin, R. K., &#38; Westram, A. M. (2019). Evolving inversions. <i>Trends in Ecology and Evolution</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tree.2018.12.005\">https://doi.org/10.1016/j.tree.2018.12.005</a>","chicago":"Faria, Rui, Kerstin Johannesson, Roger K. Butlin, and Anja M Westram. “Evolving Inversions.” <i>Trends in Ecology and Evolution</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.tree.2018.12.005\">https://doi.org/10.1016/j.tree.2018.12.005</a>.","ama":"Faria R, Johannesson K, Butlin RK, Westram AM. Evolving inversions. <i>Trends in Ecology and Evolution</i>. 2019;34(3):239-248. doi:<a href=\"https://doi.org/10.1016/j.tree.2018.12.005\">10.1016/j.tree.2018.12.005</a>","mla":"Faria, Rui, et al. “Evolving Inversions.” <i>Trends in Ecology and Evolution</i>, vol. 34, no. 3, Elsevier, 2019, pp. 239–48, doi:<a href=\"https://doi.org/10.1016/j.tree.2018.12.005\">10.1016/j.tree.2018.12.005</a>.","ieee":"R. Faria, K. Johannesson, R. K. Butlin, and A. M. Westram, “Evolving inversions,” <i>Trends in Ecology and Evolution</i>, vol. 34, no. 3. Elsevier, pp. 239–248, 2019.","ista":"Faria R, Johannesson K, Butlin RK, Westram AM. 2019. Evolving inversions. Trends in Ecology and Evolution. 34(3), 239–248.","short":"R. Faria, K. Johannesson, R.K. Butlin, A.M. Westram, Trends in Ecology and Evolution 34 (2019) 239–248."},"_id":"5911","volume":34,"page":"239-248","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"title":"Evolving inversions","scopus_import":"1","date_updated":"2026-04-16T09:48:52Z","ddc":["570"],"intvolume":"        34","isi":1,"language":[{"iso":"eng"}],"doi":"10.1016/j.tree.2018.12.005","date_created":"2019-02-03T22:59:15Z","quality_controlled":"1","external_id":{"isi":["000459899000013"]},"issue":"3"},{"tmp":{"image":"/images/cc_0.png","short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode"},"oa_version":"Published Version","has_accepted_license":"1","day":"07","fulldoi":"https://doi.org/10.1371/journal.pbio.2005902","author":[{"first_name":"Richard M.","full_name":"Merrill, Richard M.","last_name":"Merrill"},{"first_name":"Pasi","last_name":"Rastas","full_name":"Rastas, Pasi"},{"full_name":"Martin, Simon H.","last_name":"Martin","first_name":"Simon H."},{"last_name":"Melo Hurtado","full_name":"Melo Hurtado, Maria C","first_name":"Maria C","id":"386D7308-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Barker","full_name":"Barker, Sarah","first_name":"Sarah"},{"last_name":"Davey","full_name":"Davey, John","first_name":"John"},{"last_name":"Mcmillan","full_name":"Mcmillan, W. Owen","first_name":"W. Owen"},{"first_name":"Chris D.","full_name":"Jiggins, Chris D.","last_name":"Jiggins"}],"department":[{"_id":"NiBa"}],"related_material":{"record":[{"id":"9801","relation":"research_data","status":"public"}]},"publisher":"Public Library of Science","article_processing_charge":"No","year":"2019","abstract":[{"text":"The evolution of new species is made easier when traits under divergent ecological selection are also mating cues. Such ecological mating cues are now considered more common than previously thought, but we still know little about the genetic changes underlying their evolution or more generally about the genetic basis for assortative mating behaviors. Both tight physical linkage and the existence of large-effect preference loci will strengthen genetic associations between behavioral and ecological barriers, promoting the evolution of assortative mating. The warning patterns of Heliconius melpomene and H. cydno are under disruptive selection due to increased predation of nonmimetic hybrids and are used during mate recognition. We carried out a genome-wide quantitative trait locus (QTL) analysis of preference behaviors between these species and showed that divergent male preference has a simple genetic basis. We identify three QTLs that together explain a large proportion (approximately 60%) of the difference in preference behavior observed between the parental species. One of these QTLs is just 1.2 (0-4.8) centiMorgans (cM) from the major color pattern gene optix, and, individually, all three have a large effect on the preference phenotype. Genomic divergence between H. cydno and H. melpomene is high but broadly heterogenous, and admixture is reduced at the preference-optix color pattern locus but not the other preference QTLs. The simple genetic architecture we reveal will facilitate the evolution and maintenance of new species despite ongoing gene flow by coupling behavioral and ecological aspects of reproductive isolation.","lang":"eng"}],"month":"02","type":"journal_article","file_date_updated":"2020-07-14T12:47:17Z","date_published":"2019-02-07T00:00:00Z","status":"public","publication_status":"published","date_updated":"2023-08-24T14:46:23Z","scopus_import":"1","oa":1,"title":"Genetic dissection of assortative mating behavior","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6022","volume":17,"file":[{"access_level":"open_access","date_created":"2019-02-18T14:57:24Z","content_type":"application/pdf","relation":"main_file","file_name":"2019_PLOS_Merrill.pdf","file_size":2005949,"file_id":"6036","date_updated":"2020-07-14T12:47:17Z","checksum":"5f34001617ee729314ca520c049b1112","creator":"dernst"}],"citation":{"ista":"Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan WO, Jiggins CD. 2019. Genetic dissection of assortative mating behavior. PLoS Biology. 17(2), e2005902.","short":"R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey, W.O. Mcmillan, C.D. Jiggins, PLoS Biology 17 (2019).","ieee":"R. M. Merrill <i>et al.</i>, “Genetic dissection of assortative mating behavior,” <i>PLoS Biology</i>, vol. 17, no. 2. Public Library of Science, 2019.","mla":"Merrill, Richard M., et al. “Genetic Dissection of Assortative Mating Behavior.” <i>PLoS Biology</i>, vol. 17, no. 2, e2005902, Public Library of Science, 2019, doi:<a href=\"https://doi.org/10.1371/journal.pbio.2005902\">10.1371/journal.pbio.2005902</a>.","chicago":"Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado, Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Genetic Dissection of Assortative Mating Behavior.” <i>PLoS Biology</i>. Public Library of Science, 2019. <a href=\"https://doi.org/10.1371/journal.pbio.2005902\">https://doi.org/10.1371/journal.pbio.2005902</a>.","ama":"Merrill RM, Rastas P, Martin SH, et al. Genetic dissection of assortative mating behavior. <i>PLoS Biology</i>. 2019;17(2). doi:<a href=\"https://doi.org/10.1371/journal.pbio.2005902\">10.1371/journal.pbio.2005902</a>","apa":"Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S., Davey, J., … Jiggins, C. D. (2019). Genetic dissection of assortative mating behavior. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.2005902\">https://doi.org/10.1371/journal.pbio.2005902</a>"},"publication":"PLoS Biology","article_number":"e2005902","issue":"2","external_id":{"isi":["000460317100001"]},"quality_controlled":"1","date_created":"2019-02-17T22:59:21Z","doi":"10.1371/journal.pbio.2005902","language":[{"iso":"eng"}],"isi":1,"intvolume":"        17","ddc":["570"]},{"page":"189","_id":"6071","citation":{"chicago":"Prizak, Roshan. “Coevolution of Transcription Factors and Their Binding Sites in Sequence Space.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/at:ista:th6071\">https://doi.org/10.15479/at:ista:th6071</a>.","ama":"Prizak R. Coevolution of transcription factors and their binding sites in sequence space. 2019. doi:<a href=\"https://doi.org/10.15479/at:ista:th6071\">10.15479/at:ista:th6071</a>","apa":"Prizak, R. (2019). <i>Coevolution of transcription factors and their binding sites in sequence space</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:th6071\">https://doi.org/10.15479/at:ista:th6071</a>","ista":"Prizak R. 2019. Coevolution of transcription factors and their binding sites in sequence space. Institute of Science and Technology Austria.","short":"R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in Sequence Space, Institute of Science and Technology Austria, 2019.","ieee":"R. Prizak, “Coevolution of transcription factors and their binding sites in sequence space,” Institute of Science and Technology Austria, 2019.","mla":"Prizak, Roshan. <i>Coevolution of Transcription Factors and Their Binding Sites in Sequence Space</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/at:ista:th6071\">10.15479/at:ista:th6071</a>."},"file":[{"checksum":"e60a72de35d270b31f1a23d50f224ec0","creator":"rprizak","content_type":"application/pdf","file_name":"Thesis_final_PDFA_RoshanPrizak.pdf","relation":"main_file","file_size":20995465,"file_id":"6072","date_updated":"2020-07-14T12:47:18Z","access_level":"open_access","date_created":"2019-03-06T16:05:07Z"},{"checksum":"67c2630333d05ebafef5f018863a8465","creator":"rprizak","file_size":85705272,"title":"Latex files","file_id":"6073","content_type":"application/zip","file_name":"thesis_v2_merge.zip","relation":"source_file","date_updated":"2020-07-14T12:47:18Z","date_created":"2019-03-06T16:09:39Z","access_level":"closed"}],"date_updated":"2026-04-08T13:54:25Z","title":"Coevolution of transcription factors and their binding sites in sequence space","oa":1,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","doi":"10.15479/at:ista:th6071","language":[{"iso":"eng"}],"degree_awarded":"PhD","ddc":["576"],"date_created":"2019-03-06T16:16:10Z","fulldoi":"https://doi.org/10.15479/at:ista:th6071","corr_author":"1","OA_place":"publisher","department":[{"_id":"GaTk"},{"_id":"NiBa"}],"author":[{"full_name":"Prizak, Roshan","last_name":"Prizak","first_name":"Roshan","id":"4456104E-F248-11E8-B48F-1D18A9856A87"}],"related_material":{"record":[{"id":"955","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"1358"}]},"alternative_title":["ISTA Thesis"],"oa_version":"Published Version","publication_identifier":{"issn":["2663-337X"]},"day":"11","has_accepted_license":"1","type":"dissertation","file_date_updated":"2020-07-14T12:47:18Z","status":"public","date_published":"2019-03-11T00:00:00Z","supervisor":[{"first_name":"Gašper","orcid":"0000-0002-6699-1455","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkačik, Gašper","last_name":"Tkačik"}],"publication_status":"published","publisher":"Institute of Science and Technology Austria","article_processing_charge":"No","year":"2019","abstract":[{"lang":"eng","text":"Transcription factors, by binding to specific sequences on the DNA, control the precise spatio-temporal expression of genes inside a cell. However, this specificity is limited, leading to frequent incorrect binding of transcription factors that might have deleterious consequences on the cell. By constructing a biophysical model of TF-DNA binding in the context of gene regulation, I will first explore how regulatory constraints can strongly shape the distribution of a population in sequence space. Then, by directly linking this to a picture of multiple types of transcription factors performing their functions simultaneously inside the cell, I will explore the extent of regulatory crosstalk -- incorrect binding interactions between transcription factors and binding sites that lead to erroneous regulatory states -- and understand the constraints this places on the design of regulatory systems. I will then develop a generic theoretical framework to investigate the coevolution of multiple transcription factors and multiple binding sites, in the context of a gene regulatory network that performs a certain function. As a particular tractable version of this problem, I will consider the evolution of two transcription factors when they transmit upstream signals to downstream target genes. Specifically, I will describe the evolutionary steady states and the evolutionary pathways involved, along with their timescales, of a system that initially undergoes a transcription factor duplication event. To connect this important theoretical model to the prominent biological event of transcription factor duplication giving rise to paralogous families, I will then describe a bioinformatics analysis of C2H2 Zn-finger transcription factors, a major family in humans, and focus on the patterns of evolution that paralogs have undergone in their various protein domains in the recent past. "}],"project":[{"grant_number":"P28844-B27","name":"Biophysics of information processing in gene regulation","call_identifier":"FWF","_id":"254E9036-B435-11E9-9278-68D0E5697425"}],"month":"03"},{"author":[{"full_name":"Fraisse, Christelle","last_name":"Fraisse","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8441-5075","first_name":"Christelle"},{"last_name":"Puixeu Sala","full_name":"Puixeu Sala, Gemma","first_name":"Gemma","orcid":"0000-0001-8330-1754","id":"33AB266C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","full_name":"Vicoso, Beatriz"}],"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"related_material":{"record":[{"status":"public","relation":"popular_science","id":"5757"}]},"fulldoi":"https://doi.org/10.1093/molbev/msy246","day":"01","publication_identifier":{"issn":["0737-4038"],"eissn":["1537-1719"]},"oa_version":"Submitted Version","publication_status":"published","status":"public","date_published":"2019-03-01T00:00:00Z","type":"journal_article","month":"03","abstract":[{"text":"Pleiotropy is the well-established idea that a single mutation affects multiple phenotypes. If a mutation has opposite effects on fitness when expressed in different contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce the efficacy of selection by limiting the fixation of beneficial mutations through adaptation, and the removal of deleterious mutations through purifying selection. Although this has been widely discussed, in particular in the context of a putative “gender load,” it has yet to be systematically quantified. In this work, we empirically estimate to which extent different pleiotropic regimes impede the efficacy of selection in Drosophila melanogaster. We use whole-genome polymorphism data from a single African population and divergence data from D. simulans to estimate the fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction of selection (DoS). After controlling for confounding covariates, we find that the different pleiotropic regimes have a relatively small, but significant, effect on selection efficacy. Specifically, our results suggest that pleiotropic sexual antagonism may restrict the efficacy of selection, but that this conflict can be resolved by limiting the expression of genes to the sex where they are beneficial. Intermediate levels of pleiotropy across tissues and life stages can also lead to maladaptation in D. melanogaster, due to inefficient purifying selection combined with low frequency of mutations that confer a selective advantage. Thus, our study highlights the need to consider the efficacy of selection in the context of antagonistic pleiotropy, and of genetic conflict in general.","lang":"eng"}],"project":[{"name":"Sex chromosome evolution under male- and female- heterogamety","call_identifier":"FWF","_id":"250ED89C-B435-11E9-9278-68D0E5697425","grant_number":"P28842-B22"}],"publisher":"Oxford University Press","article_processing_charge":"No","year":"2019","publication":"Molecular biology and evolution","citation":{"apa":"Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>","ama":"Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515. doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>","chicago":"Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>.","ieee":"C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>, vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.","mla":"Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36, no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>.","short":"C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36 (2019) 500–515.","ista":"Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. Molecular biology and evolution. 36(3), 500–515."},"_id":"6089","volume":36,"page":"500-515","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/30590559","open_access":"1"}],"oa":1,"title":"Pleiotropy modulates the efficacy of selection in drosophila melanogaster","date_updated":"2025-04-15T08:18:38Z","scopus_import":"1","isi":1,"intvolume":"        36","language":[{"iso":"eng"}],"doi":"10.1093/molbev/msy246","date_created":"2019-03-10T22:59:19Z","quality_controlled":"1","external_id":{"pmid":["30590559"],"isi":["000462585100006"]},"pmid":1,"issue":"3"},{"citation":{"apa":"Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R., Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>","ama":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. 2019;99(2). doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>","chicago":"Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>.","ieee":"M. Carballo-Pacheco <i>et al.</i>, “Receptor crosstalk improves concentration sensing of multiple ligands,” <i>Physical Review E</i>, vol. 99, no. 2. American Physical Society, 2019.","mla":"Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>, vol. 99, no. 2, 022423, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>.","short":"M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G. Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).","ista":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G, Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of multiple ligands. Physical Review E. 99(2), 022423."},"publication":"Physical Review E","volume":99,"_id":"6090","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/448118v1.abstract"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-02-28T13:12:06Z","scopus_import":"1","title":"Receptor crosstalk improves concentration sensing of multiple ligands","oa":1,"isi":1,"intvolume":"        99","doi":"10.1103/PhysRevE.99.022423","language":[{"iso":"eng"}],"quality_controlled":"1","date_created":"2019-03-10T22:59:20Z","issue":"2","article_number":"022423","external_id":{"isi":["000459916500007"]},"author":[{"first_name":"Martín","last_name":"Carballo-Pacheco","full_name":"Carballo-Pacheco, Martín"},{"first_name":"Jonathan","full_name":"Desponds, Jonathan","last_name":"Desponds"},{"last_name":"Gavrilchenko","full_name":"Gavrilchenko, Tatyana","first_name":"Tatyana"},{"full_name":"Mayer, Andreas","last_name":"Mayer","first_name":"Andreas"},{"full_name":"Prizak, Roshan","last_name":"Prizak","id":"4456104E-F248-11E8-B48F-1D18A9856A87","first_name":"Roshan"},{"first_name":"Gautam","full_name":"Reddy, Gautam","last_name":"Reddy"},{"full_name":"Nemenman, Ilya","last_name":"Nemenman","first_name":"Ilya"},{"first_name":"Thierry","last_name":"Mora","full_name":"Mora, Thierry"}],"department":[{"_id":"NiBa"},{"_id":"GaTk"}],"fulldoi":"https://doi.org/10.1103/PhysRevE.99.022423","day":"26","oa_version":"Preprint","status":"public","date_published":"2019-02-26T00:00:00Z","publication_status":"published","type":"journal_article","month":"02","publisher":"American Physical Society","year":"2019","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems, leading to crosstalk between ligand-receptor pairs. Crosstalk is often thought of as a deviation from optimal specific recognition, as the binding of noncognate ligands can interfere with the detection of the receptor's cognate ligand, possibly leading to a false triggering of a downstream signaling pathway. Here we quantify the optimal precision of sensing the concentrations of multiple ligands by a collection of promiscuous receptors. We demonstrate that crosstalk can improve precision in concentration sensing and discrimination tasks. To achieve superior precision, the additional information about ligand concentrations contained in short binding events of the noncognate ligand should be exploited. We present a proofreading scheme to realize an approximate estimation of multiple ligand concentrations that reaches a precision close to the derived optimal bounds. Our results help rationalize the observed ubiquity of receptor crosstalk in molecular sensing."}]},{"fulldoi":"https://doi.org/10.1111/mec.14972","author":[{"first_name":"Rui","last_name":"Faria","full_name":"Faria, Rui"},{"first_name":"Pragya","full_name":"Chaube, Pragya","last_name":"Chaube"},{"last_name":"Morales","full_name":"Morales, Hernán E.","first_name":"Hernán E."},{"full_name":"Larsson, Tomas","last_name":"Larsson","first_name":"Tomas"},{"full_name":"Lemmon, Alan R.","last_name":"Lemmon","first_name":"Alan R."},{"first_name":"Emily M.","full_name":"Lemmon, Emily M.","last_name":"Lemmon"},{"first_name":"Marina","full_name":"Rafajlović, Marina","last_name":"Rafajlović"},{"full_name":"Panova, Marina","last_name":"Panova","first_name":"Marina"},{"first_name":"Mark","full_name":"Ravinet, Mark","last_name":"Ravinet"},{"full_name":"Johannesson, Kerstin","last_name":"Johannesson","first_name":"Kerstin"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","orcid":"0000-0003-1050-4969","last_name":"Westram","full_name":"Westram, Anja M"},{"first_name":"Roger K.","full_name":"Butlin, Roger K.","last_name":"Butlin"}],"department":[{"_id":"NiBa"}],"related_material":{"record":[{"relation":"research_data","id":"9837","status":"public"}]},"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"has_accepted_license":"1","day":"01","type":"journal_article","file_date_updated":"2020-07-14T12:47:19Z","date_published":"2019-03-01T00:00:00Z","status":"public","publication_status":"published","publisher":"Wiley","article_processing_charge":"No","year":"2019","abstract":[{"lang":"eng","text":"Both classical and recent studies suggest that chromosomal inversion polymorphisms are important in adaptation and speciation. However, biases in discovery and reporting of inversions make it difficult to assess their prevalence and biological importance. Here, we use an approach based on linkage disequilibrium among markers genotyped for samples collected across a transect between contrasting habitats to detect chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in a single locality for the coastal marine snail, Littorina saxatilis. Patterns of diversity in the field and of recombination in controlled crosses provide strong evidence that at least the majority of these rearrangements are inversions. Most show clinal changes in frequency between habitats, suggestive of divergent selection, but only one appears to be fixed for different arrangements in the two habitats. Consistent with widespread evidence for balancing selection on inversion polymorphisms, we argue that a combination of heterosis and divergent selection can explain the observed patterns and should be considered in other systems spanning environmental gradients."}],"month":"03","page":"1375-1393","volume":28,"_id":"6095","file":[{"access_level":"open_access","date_created":"2019-03-11T16:12:54Z","file_name":"2019_MolecularEcology_Faria.pdf","relation":"main_file","content_type":"application/pdf","file_size":1510715,"file_id":"6097","date_updated":"2020-07-14T12:47:19Z","checksum":"f915885756057ec0ca5912a41f46a887","creator":"dernst"}],"citation":{"apa":"Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon, E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>","ama":"Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. 2019;28(6):1375-1393. doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>","chicago":"Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon, Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>.","mla":"Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>, vol. 28, no. 6, Wiley, 2019, pp. 1375–93, doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>.","ieee":"R. Faria <i>et al.</i>, “Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes,” <i>Molecular Ecology</i>, vol. 28, no. 6. Wiley, pp. 1375–1393, 2019.","short":"R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon, M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin, Molecular Ecology 28 (2019) 1375–1393.","ista":"Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular Ecology. 28(6), 1375–1393."},"publication":"Molecular Ecology","date_updated":"2023-08-24T14:50:27Z","scopus_import":"1","title":"Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1111/mec.14972","language":[{"iso":"eng"}],"isi":1,"intvolume":"        28","ddc":["570"],"issue":"6","external_id":{"isi":["000465219200013"]},"quality_controlled":"1","date_created":"2019-03-10T22:59:21Z"},{"intvolume":"         8","isi":1,"ddc":["570"],"doi":"10.7554/eLife.45380","language":[{"iso":"eng"}],"quality_controlled":"1","date_created":"2019-04-07T21:59:15Z","article_number":"e45380","external_id":{"isi":["000461988300001"]},"file":[{"relation":"main_file","content_type":"application/pdf","file_name":"2019_eLife_Barton.pdf","file_size":298466,"file_id":"6293","date_updated":"2020-07-14T12:47:24Z","access_level":"open_access","date_created":"2019-04-11T11:43:38Z","checksum":"130d7544b57df4a6787e1263c2d7ea43","creator":"dernst"}],"citation":{"apa":"Barton, N. H., Hermisson, J., &#38; Nordborg, M. (2019). Why structure matters. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>","ama":"Barton NH, Hermisson J, Nordborg M. Why structure matters. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>","chicago":"Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure Matters.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>.","ieee":"N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","mla":"Barton, Nicholas H., et al. “Why Structure Matters.” <i>ELife</i>, vol. 8, e45380, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>.","short":"N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019).","ista":"Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8, e45380."},"publication":"eLife","_id":"6230","volume":8,"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","scopus_import":"1","date_updated":"2026-04-02T14:03:15Z","title":"Why structure matters","oa":1,"status":"public","date_published":"2019-03-21T00:00:00Z","publication_status":"published","type":"journal_article","file_date_updated":"2020-07-14T12:47:24Z","month":"03","article_processing_charge":"No","year":"2019","publisher":"eLife Sciences Publications","abstract":[{"lang":"eng","text":"Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies."}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/","description":"News on IST Homepage","relation":"press_release"}]},"author":[{"full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Joachim","last_name":"Hermisson","full_name":"Hermisson, Joachim"},{"full_name":"Nordborg, Magnus","last_name":"Nordborg","first_name":"Magnus"}],"department":[{"_id":"NiBa"}],"fulldoi":"https://doi.org/10.7554/eLife.45380","has_accepted_license":"1","day":"21","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["2050-084X"]}},{"fulldoi":"https://doi.org/10.1002/9781119487845.ch4","department":[{"_id":"NiBa"}],"author":[{"orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H"},{"last_name":"Etheridge","full_name":"Etheridge, Alison","first_name":"Alison"}],"oa_version":"None","publication_identifier":{"isbn":["9781119429142"]},"day":"29","type":"book_chapter","status":"public","date_published":"2019-07-29T00:00:00Z","publication_status":"published","year":"2019","article_processing_charge":"No","publisher":"Wiley","abstract":[{"text":"We review the history of population genetics, starting with its origins a century ago from the synthesis between Mendel and Darwin's ideas, through to the recent development of sophisticated schemes of inference from sequence data, based on the coalescent. We explain the close relation between the coalescent and a diffusion process, which we illustrate by their application to understand spatial structure. We summarise the powerful methods available for analysis of multiple loci, when linkage equilibrium can be assumed, and then discuss approaches to the more challenging case, where associations between alleles require that we follow genotype, rather than allele, frequencies. Though we can hardly cover the whole of population genetics, we give an overview of the current state of the subject, and future challenges to it.","lang":"eng"}],"month":"07","page":"115-144","_id":"8281","citation":{"ista":"Barton NH, Etheridge A. 2019.Mathematical models in population genetics. In: Handbook of statistical genomics. , 115–144.","short":"N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.), Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144.","ieee":"N. H. Barton and A. Etheridge, “Mathematical models in population genetics,” in <i>Handbook of statistical genomics</i>, 4th ed., D. Balding, I. Moltke, and J. Marioni, Eds. Wiley, 2019, pp. 115–144.","mla":"Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population Genetics.” <i>Handbook of Statistical Genomics</i>, edited by David Balding et al., 4th ed., Wiley, 2019, pp. 115–44, doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>.","chicago":"Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population Genetics.” In <i>Handbook of Statistical Genomics</i>, edited by David Balding, Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>.","ama":"Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding D, Moltke I, Marioni J, eds. <i>Handbook of Statistical Genomics</i>. 4th ed. Wiley; 2019:115-144. doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>","apa":"Barton, N. H., &#38; Etheridge, A. (2019). Mathematical models in population genetics. In D. Balding, I. Moltke, &#38; J. Marioni (Eds.), <i>Handbook of statistical genomics</i> (4th ed., pp. 115–144). Wiley. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>"},"publication":"Handbook of statistical genomics","scopus_import":"1","date_updated":"2024-10-21T06:02:39Z","title":"Mathematical models in population genetics","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","doi":"10.1002/9781119487845.ch4","edition":"4","language":[{"iso":"eng"}],"isi":1,"ddc":["576"],"external_id":{"isi":["000261343000003"]},"quality_controlled":"1","editor":[{"last_name":"Balding","full_name":"Balding, David","first_name":"David"},{"last_name":"Moltke","full_name":"Moltke, Ida","first_name":"Ida"},{"last_name":"Marioni","full_name":"Marioni, John","first_name":"John"}],"date_created":"2020-08-21T04:25:39Z"}]