[{"citation":{"ama":"Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. 2019;28(6):1375-1393. doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>","apa":"Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon, E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>","short":"R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon, M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin, Molecular Ecology 28 (2019) 1375–1393.","chicago":"Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon, Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>.","ieee":"R. Faria <i>et al.</i>, “Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes,” <i>Molecular Ecology</i>, vol. 28, no. 6. Wiley, pp. 1375–1393, 2019.","mla":"Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>, vol. 28, no. 6, Wiley, 2019, pp. 1375–93, doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>.","ista":"Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular Ecology. 28(6), 1375–1393."},"issue":"6","has_accepted_license":"1","related_material":{"record":[{"relation":"research_data","status":"public","id":"9837"}]},"isi":1,"publication_status":"published","author":[{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"full_name":"Chaube, Pragya","last_name":"Chaube","first_name":"Pragya"},{"full_name":"Morales, Hernán E.","last_name":"Morales","first_name":"Hernán E."},{"first_name":"Tomas","full_name":"Larsson, Tomas","last_name":"Larsson"},{"full_name":"Lemmon, Alan R.","last_name":"Lemmon","first_name":"Alan R."},{"first_name":"Emily M.","last_name":"Lemmon","full_name":"Lemmon, Emily M."},{"first_name":"Marina","full_name":"Rafajlović, Marina","last_name":"Rafajlović"},{"first_name":"Marina","last_name":"Panova","full_name":"Panova, Marina"},{"last_name":"Ravinet","full_name":"Ravinet, Mark","first_name":"Mark"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","last_name":"Westram","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969"},{"last_name":"Butlin","full_name":"Butlin, Roger K.","first_name":"Roger K."}],"department":[{"_id":"NiBa"}],"month":"03","volume":28,"intvolume":"        28","ddc":["570"],"scopus_import":"1","language":[{"iso":"eng"}],"page":"1375-1393","oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"doi":"10.1111/mec.14972","date_updated":"2023-08-24T14:50:27Z","status":"public","publication_identifier":{"issn":["0962-1083"],"eissn":["1365-294X"]},"publisher":"Wiley","abstract":[{"lang":"eng","text":"Both classical and recent studies suggest that chromosomal inversion polymorphisms are important in adaptation and speciation. However, biases in discovery and reporting of inversions make it difficult to assess their prevalence and biological importance. Here, we use an approach based on linkage disequilibrium among markers genotyped for samples collected across a transect between contrasting habitats to detect chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in a single locality for the coastal marine snail, Littorina saxatilis. Patterns of diversity in the field and of recombination in controlled crosses provide strong evidence that at least the majority of these rearrangements are inversions. Most show clinal changes in frequency between habitats, suggestive of divergent selection, but only one appears to be fixed for different arrangements in the two habitats. Consistent with widespread evidence for balancing selection on inversion polymorphisms, we argue that a combination of heterosis and divergent selection can explain the observed patterns and should be considered in other systems spanning environmental gradients."}],"title":"Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes","quality_controlled":"1","file":[{"relation":"main_file","date_created":"2019-03-11T16:12:54Z","access_level":"open_access","file_size":1510715,"creator":"dernst","file_name":"2019_MolecularEcology_Faria.pdf","date_updated":"2020-07-14T12:47:19Z","checksum":"f915885756057ec0ca5912a41f46a887","content_type":"application/pdf","file_id":"6097"}],"type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Molecular Ecology","article_processing_charge":"No","day":"01","year":"2019","file_date_updated":"2020-07-14T12:47:19Z","date_created":"2019-03-10T22:59:21Z","date_published":"2019-03-01T00:00:00Z","_id":"6095","external_id":{"isi":["000465219200013"]}},{"has_accepted_license":"1","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/","relation":"press_release"}]},"article_number":"e45380","citation":{"chicago":"Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure Matters.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>.","ieee":"N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","mla":"Barton, Nicholas H., et al. “Why Structure Matters.” <i>ELife</i>, vol. 8, e45380, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>.","ista":"Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8, e45380.","ama":"Barton NH, Hermisson J, Nordborg M. Why structure matters. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>","apa":"Barton, N. H., Hermisson, J., &#38; Nordborg, M. (2019). Why structure matters. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>","short":"N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019)."},"language":[{"iso":"eng"}],"oa_version":"Published Version","intvolume":"         8","ddc":["570"],"scopus_import":"1","isi":1,"publication_status":"published","author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"first_name":"Joachim","last_name":"Hermisson","full_name":"Hermisson, Joachim"},{"full_name":"Nordborg, Magnus","last_name":"Nordborg","first_name":"Magnus"}],"department":[{"_id":"NiBa"}],"month":"03","volume":8,"publisher":"eLife Sciences Publications","quality_controlled":"1","title":"Why structure matters","abstract":[{"lang":"eng","text":"Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies."}],"file":[{"file_name":"2019_eLife_Barton.pdf","date_created":"2019-04-11T11:43:38Z","relation":"main_file","access_level":"open_access","file_size":298466,"creator":"dernst","content_type":"application/pdf","checksum":"130d7544b57df4a6787e1263c2d7ea43","file_id":"6293","date_updated":"2020-07-14T12:47:24Z"}],"publication_identifier":{"eissn":["2050-084X"]},"doi":"10.7554/eLife.45380","status":"public","date_updated":"2026-04-02T14:03:15Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"date_created":"2019-04-07T21:59:15Z","date_published":"2019-03-21T00:00:00Z","_id":"6230","external_id":{"isi":["000461988300001"]},"year":"2019","file_date_updated":"2020-07-14T12:47:24Z","article_processing_charge":"No","day":"21","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","publication":"eLife"},{"citation":{"chicago":"Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population Genetics.” In <i>Handbook of Statistical Genomics</i>, edited by David Balding, Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>.","ieee":"N. H. Barton and A. Etheridge, “Mathematical models in population genetics,” in <i>Handbook of statistical genomics</i>, 4th ed., D. Balding, I. Moltke, and J. Marioni, Eds. Wiley, 2019, pp. 115–144.","mla":"Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population Genetics.” <i>Handbook of Statistical Genomics</i>, edited by David Balding et al., 4th ed., Wiley, 2019, pp. 115–44, doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>.","ista":"Barton NH, Etheridge A. 2019.Mathematical models in population genetics. In: Handbook of statistical genomics. , 115–144.","ama":"Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding D, Moltke I, Marioni J, eds. <i>Handbook of Statistical Genomics</i>. 4th ed. Wiley; 2019:115-144. doi:<a href=\"https://doi.org/10.1002/9781119487845.ch4\">10.1002/9781119487845.ch4</a>","apa":"Barton, N. H., &#38; Etheridge, A. (2019). Mathematical models in population genetics. In D. Balding, I. Moltke, &#38; J. Marioni (Eds.), <i>Handbook of statistical genomics</i> (4th ed., pp. 115–144). Wiley. <a href=\"https://doi.org/10.1002/9781119487845.ch4\">https://doi.org/10.1002/9781119487845.ch4</a>","short":"N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.), Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144."},"edition":"4","editor":[{"full_name":"Balding, David","last_name":"Balding","first_name":"David"},{"first_name":"Ida","last_name":"Moltke","full_name":"Moltke, Ida"},{"first_name":"John","full_name":"Marioni, John","last_name":"Marioni"}],"language":[{"iso":"eng"}],"page":"115-144","oa_version":"None","ddc":["576"],"scopus_import":"1","publication_status":"published","isi":1,"department":[{"_id":"NiBa"}],"author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"full_name":"Etheridge, Alison","last_name":"Etheridge","first_name":"Alison"}],"month":"07","publisher":"Wiley","quality_controlled":"1","title":"Mathematical models in population genetics","abstract":[{"text":"We review the history of population genetics, starting with its origins a century ago from the synthesis between Mendel and Darwin's ideas, through to the recent development of sophisticated schemes of inference from sequence data, based on the coalescent. We explain the close relation between the coalescent and a diffusion process, which we illustrate by their application to understand spatial structure. We summarise the powerful methods available for analysis of multiple loci, when linkage equilibrium can be assumed, and then discuss approaches to the more challenging case, where associations between alleles require that we follow genotype, rather than allele, frequencies. Though we can hardly cover the whole of population genetics, we give an overview of the current state of the subject, and future challenges to it.","lang":"eng"}],"publication_identifier":{"isbn":["9781119429142"]},"status":"public","date_updated":"2024-10-21T06:02:39Z","doi":"10.1002/9781119487845.ch4","date_created":"2020-08-21T04:25:39Z","date_published":"2019-07-29T00:00:00Z","external_id":{"isi":["000261343000003"]},"_id":"8281","year":"2019","article_processing_charge":"No","day":"29","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"book_chapter","publication":"Handbook of statistical genomics"},{"department":[{"_id":"NiBa"}],"author":[{"last_name":"Merrill","full_name":"Merrill, Richard M.","first_name":"Richard M."},{"first_name":"Pasi","last_name":"Rastas","full_name":"Rastas, Pasi"},{"first_name":"Simon H.","full_name":"Martin, Simon H.","last_name":"Martin"},{"full_name":"Melo Hurtado, Maria C","last_name":"Melo Hurtado","id":"386D7308-F248-11E8-B48F-1D18A9856A87","first_name":"Maria C"},{"last_name":"Barker","full_name":"Barker, Sarah","first_name":"Sarah"},{"last_name":"Davey","full_name":"Davey, John","first_name":"John"},{"last_name":"Mcmillan","full_name":"Mcmillan, W. Owen","first_name":"W. Owen"},{"last_name":"Jiggins","full_name":"Jiggins, Chris D.","first_name":"Chris D."}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","month":"02","day":"07","article_processing_charge":"No","year":"2019","oa_version":"Published Version","date_created":"2021-08-06T11:34:56Z","_id":"9801","date_published":"2019-02-07T00:00:00Z","doi":"10.1371/journal.pbio.2005902.s006","status":"public","date_updated":"2023-08-24T14:46:23Z","citation":{"ista":"Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan WO, Jiggins CD. 2019. Raw behavioral data, Public Library of Science, <a href=\"https://doi.org/10.1371/journal.pbio.2005902.s006\">10.1371/journal.pbio.2005902.s006</a>.","mla":"Merrill, Richard M., et al. <i>Raw Behavioral Data</i>. Public Library of Science, 2019, doi:<a href=\"https://doi.org/10.1371/journal.pbio.2005902.s006\">10.1371/journal.pbio.2005902.s006</a>.","chicago":"Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado, Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Raw Behavioral Data.” Public Library of Science, 2019. <a href=\"https://doi.org/10.1371/journal.pbio.2005902.s006\">https://doi.org/10.1371/journal.pbio.2005902.s006</a>.","ieee":"R. M. Merrill <i>et al.</i>, “Raw behavioral data.” Public Library of Science, 2019.","short":"R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey, W.O. Mcmillan, C.D. Jiggins, (2019).","apa":"Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S., Davey, J., … Jiggins, C. D. (2019). Raw behavioral data. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.2005902.s006\">https://doi.org/10.1371/journal.pbio.2005902.s006</a>","ama":"Merrill RM, Rastas P, Martin SH, et al. Raw behavioral data. 2019. doi:<a href=\"https://doi.org/10.1371/journal.pbio.2005902.s006\">10.1371/journal.pbio.2005902.s006</a>"},"title":"Raw behavioral data","publisher":"Public Library of Science","related_material":{"record":[{"id":"6022","status":"public","relation":"used_in_publication"}]}},{"oa_version":"Published Version","year":"2019","_id":"9802","date_published":"2019-07-16T00:00:00Z","date_created":"2021-08-06T11:45:11Z","month":"07","author":[{"id":"42377A0A-F248-11E8-B48F-1D18A9856A87","first_name":"Himani","last_name":"Sachdeva","full_name":"Sachdeva, Himani"}],"department":[{"_id":"NiBa"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","day":"16","article_processing_charge":"No","main_file_link":[{"url":"https://doi.org/10.5061/dryad.8tp0900","open_access":"1"}],"citation":{"mla":"Sachdeva, Himani. <i>Data from: Effect of Partial Selfing and Polygenic Selection on Establishment in a New Habitat</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>.","chicago":"Sachdeva, Himani. “Data from: Effect of Partial Selfing and Polygenic Selection on Establishment in a New Habitat.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.8tp0900\">https://doi.org/10.5061/dryad.8tp0900</a>.","ieee":"H. Sachdeva, “Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat.” Dryad, 2019.","ista":"Sachdeva H. 2019. Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat, Dryad, <a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>.","apa":"Sachdeva, H. (2019). Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat. Dryad. <a href=\"https://doi.org/10.5061/dryad.8tp0900\">https://doi.org/10.5061/dryad.8tp0900</a>","ama":"Sachdeva H. Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>","short":"H. Sachdeva, (2019)."},"related_material":{"record":[{"relation":"used_in_publication","id":"6680","status":"public"}]},"title":"Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat","abstract":[{"lang":"eng","text":"This paper analyzes how partial selfing in a large source population influences its ability to colonize a new habitat via the introduction of a few founder individuals. Founders experience inbreeding depression due to partially recessive deleterious alleles as well as maladaptation to the new environment due to selection on a large number of additive loci. I first introduce a simplified version of the Inbreeding History Model (Kelly, 2007) in order to characterize mutation-selection balance in a large, partially selfing source population under selection involving multiple non-identical loci. I then use individual-based simulations to study the eco-evolutionary dynamics of founders establishing in the new habitat under a model of hard selection. The study explores how selfing rate shapes establishment probabilities of founders via effects on both inbreeding depression and adaptability to the new environment, and also distinguishes the effects of selfing on the initial fitness of founders from its effects on the long-term adaptive response of the populations they found. A high rate of (but not complete) selfing is found to aid establishment over a wide range of parameters, even in the absence of mate limitation. The sensitivity of the results to assumptions about the nature of polygenic selection are discussed."}],"publisher":"Dryad","oa":1,"status":"public","doi":"10.5061/dryad.8tp0900","date_updated":"2024-10-09T20:58:56Z"},{"_id":"9803","date_published":"2019-07-22T00:00:00Z","date_created":"2021-08-06T11:48:42Z","oa_version":"Published Version","year":"2019","day":"22","article_processing_charge":"No","month":"07","department":[{"_id":"NiBa"},{"_id":"BeVi"}],"author":[{"id":"33AB266C-F248-11E8-B48F-1D18A9856A87","first_name":"Gemma","orcid":"0000-0001-8330-1754","last_name":"Puixeu Sala","full_name":"Puixeu Sala, Gemma"},{"orcid":"0000-0001-6118-0541","full_name":"Pickup, Melinda","last_name":"Pickup","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","first_name":"Melinda"},{"first_name":"David","full_name":"Field, David","last_name":"Field"},{"first_name":"Spencer C.H.","last_name":"Barrett","full_name":"Barrett, Spencer C.H."}],"type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","related_material":{"record":[{"status":"public","id":"6831","relation":"used_in_publication"},{"relation":"used_in_publication","status":"public","id":"14058"}]},"title":"Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics","abstract":[{"lang":"eng","text":"Understanding the mechanisms causing phenotypic differences between females and males has long fascinated evolutionary biologists. An extensive literature exists on animal sexual dimorphism but less is known about sex differences in plants, particularly the extent of geographical variation in sexual dimorphism and its life-cycle dynamics. Here, we investigate patterns of genetically-based sexual dimorphism in vegetative and reproductive traits of a wind-pollinated dioecious plant, Rumex hastatulus, across three life-cycle stages using open-pollinated families from 30 populations spanning the geographic range and chromosomal variation (XY and XY1Y2) of the species. The direction and degree of sexual dimorphism was highly variable among populations and life-cycle stages. Sex-specific differences in reproductive function explained a significant amount of temporal change in sexual dimorphism. For several traits, geographical variation in sexual dimorphism was associated with bioclimatic parameters, likely due to the differential responses of the sexes to climate. We found no systematic differences in sexual dimorphism between chromosome races. Sex-specific trait differences in dioecious plants largely result from a balance between sexual and natural selection on resource allocation. Our results indicate that abiotic factors associated with geographical context also play a role in modifying sexual dimorphism during the plant life cycle."}],"publisher":"Dryad","main_file_link":[{"url":"https://doi.org/10.5061/dryad.n1701c9","open_access":"1"}],"citation":{"mla":"Puixeu Sala, Gemma, et al. <i>Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>.","ieee":"G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics.” Dryad, 2019.","chicago":"Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett. “Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.n1701c9\">https://doi.org/10.5061/dryad.n1701c9</a>.","ista":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics, Dryad, <a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>.","apa":"Puixeu Sala, G., Pickup, M., Field, D., &#38; Barrett, S. C. H. (2019). Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics. Dryad. <a href=\"https://doi.org/10.5061/dryad.n1701c9\">https://doi.org/10.5061/dryad.n1701c9</a>","ama":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>","short":"G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, (2019)."},"doi":"10.5061/dryad.n1701c9","date_updated":"2026-04-07T13:25:33Z","status":"public","oa":1},{"status":"public","doi":"10.5061/dryad.0q2h6tk","date_updated":"2023-08-29T06:41:51Z","oa":1,"related_material":{"record":[{"id":"6713","status":"public","relation":"used_in_publication"}]},"publisher":"Dryad","abstract":[{"lang":"eng","text":"Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicates. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci tending to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivating two limb enhancers of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response."}],"title":"Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice","main_file_link":[{"url":"https://doi.org/10.5061/dryad.0q2h6tk","open_access":"1"}],"citation":{"ista":"Castro JP, Yancoskie MN, Marchini M, Belohlavy S, Hiramatsu L, Kučka M, Beluch WH, Naumann R, Skuplik I, Cobb J, Barton NH, Rolian C, Chan YF. 2019. Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice, Dryad, <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>.","chicago":"Castro, João Pl, Michelle N. Yancoskie, Marta Marchini, Stefanie Belohlavy, Layla Hiramatsu, Marek Kučka, William H. Beluch, et al. “Data from: An Integrative Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">https://doi.org/10.5061/dryad.0q2h6tk</a>.","ieee":"J. P. Castro <i>et al.</i>, “Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice.” Dryad, 2019.","mla":"Castro, João Pl, et al. <i>Data from: An Integrative Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>.","short":"J.P. Castro, M.N. Yancoskie, M. Marchini, S. Belohlavy, L. Hiramatsu, M. Kučka, W.H. Beluch, R. Naumann, I. Skuplik, J. Cobb, N.H. Barton, C. Rolian, Y.F. Chan, (2019).","ama":"Castro JP, Yancoskie MN, Marchini M, et al. Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>","apa":"Castro, J. P., Yancoskie, M. N., Marchini, M., Belohlavy, S., Hiramatsu, L., Kučka, M., … Chan, Y. F. (2019). Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice. Dryad. <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">https://doi.org/10.5061/dryad.0q2h6tk</a>"},"article_processing_charge":"No","day":"06","month":"06","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","author":[{"last_name":"Castro","full_name":"Castro, João Pl","first_name":"João Pl"},{"first_name":"Michelle N.","full_name":"Yancoskie, Michelle N.","last_name":"Yancoskie"},{"full_name":"Marchini, Marta","last_name":"Marchini","first_name":"Marta"},{"full_name":"Belohlavy, Stefanie","last_name":"Belohlavy","orcid":"0000-0002-9849-498X","id":"43FE426A-F248-11E8-B48F-1D18A9856A87","first_name":"Stefanie"},{"last_name":"Hiramatsu","full_name":"Hiramatsu, Layla","first_name":"Layla"},{"last_name":"Kučka","full_name":"Kučka, Marek","first_name":"Marek"},{"last_name":"Beluch","full_name":"Beluch, William H.","first_name":"William H."},{"full_name":"Naumann, Ronald","last_name":"Naumann","first_name":"Ronald"},{"full_name":"Skuplik, Isabella","last_name":"Skuplik","first_name":"Isabella"},{"last_name":"Cobb","full_name":"Cobb, John","first_name":"John"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H"},{"full_name":"Rolian, Campbell","last_name":"Rolian","first_name":"Campbell"},{"first_name":"Yingguang Frank","full_name":"Chan, Yingguang Frank","last_name":"Chan"}],"department":[{"_id":"NiBa"}],"date_published":"2019-06-06T00:00:00Z","_id":"9804","date_created":"2021-08-06T11:52:54Z","oa_version":"Published Version","year":"2019"},{"main_file_link":[{"url":"https://doi.org/10.5061/dryad.2kb6fh4","open_access":"1"}],"citation":{"ama":"Barton NH. Data from: The consequences of an introgression event. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>","apa":"Barton, N. H. (2019). Data from: The consequences of an introgression event. Dryad. <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">https://doi.org/10.5061/dryad.2kb6fh4</a>","short":"N.H. Barton, (2019).","ieee":"N. H. Barton, “Data from: The consequences of an introgression event.” Dryad, 2019.","chicago":"Barton, Nicholas H. “Data from: The Consequences of an Introgression Event.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">https://doi.org/10.5061/dryad.2kb6fh4</a>.","mla":"Barton, Nicholas H. <i>Data from: The Consequences of an Introgression Event</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>.","ista":"Barton NH. 2019. Data from: The consequences of an introgression event, Dryad, <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>."},"related_material":{"record":[{"id":"40","status":"public","relation":"used_in_publication"}]},"abstract":[{"text":"The spread of adaptive alleles is fundamental to evolution, and in theory, this process is well‐understood. However, only rarely can we follow this process—whether it originates from the spread of a new mutation, or by introgression from another population. In this issue of Molecular Ecology, Hanemaaijer et al. (2018) report on a 25‐year long study of the mosquitoes Anopheles gambiae (Figure 1) and Anopheles coluzzi in Mali, based on genotypes at 15 single‐nucleotide polymorphism (SNP). The species are usually reproductively isolated from each other, but in 2002 and 2006, bursts of hybridization were observed, when F1 hybrids became abundant. Alleles backcrossed from A. gambiae into A. coluzzi, but after the first event, these declined over the following years. In contrast, after 2006, an insecticide resistance allele that had established in A. gambiae spread into A. coluzzi, and rose to high frequency there, over 6 years (~75 generations). Whole genome sequences of 74 individuals showed that A. gambiae SNP from across the genome had become common in the A. coluzzi population, but that most of these were clustered in 34 genes around the resistance locus. A new set of SNP from 25 of these genes were assayed over time; over the 4 years since near‐fixation of the resistance allele; some remained common, whereas others declined. What do these patterns tell us about this introgression event?","lang":"eng"}],"title":"Data from: The consequences of an introgression event","publisher":"Dryad","oa":1,"status":"public","doi":"10.5061/dryad.2kb6fh4","date_updated":"2025-07-10T11:52:34Z","oa_version":"Published Version","year":"2019","_id":"9805","date_published":"2019-01-09T00:00:00Z","date_created":"2021-08-06T12:03:50Z","month":"01","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H"}],"department":[{"_id":"NiBa"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","day":"09","article_processing_charge":"No"},{"oa":1,"date_updated":"2025-07-10T11:52:26Z","doi":"10.5061/dryad.5vv37","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.5vv37"}],"citation":{"ista":"Polechova J. 2019. Data from: Is the sky the limit? On the expansion threshold of a species’ range, Dryad, <a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>.","mla":"Polechova, Jitka. <i>Data from: Is the Sky the Limit? On the Expansion Threshold of a Species’ Range</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>.","ieee":"J. Polechova, “Data from: Is the sky the limit? On the expansion threshold of a species’ range.” Dryad, 2019.","chicago":"Polechova, Jitka. “Data from: Is the Sky the Limit? On the Expansion Threshold of a Species’ Range.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.5vv37\">https://doi.org/10.5061/dryad.5vv37</a>.","short":"J. Polechova, (2019).","apa":"Polechova, J. (2019). Data from: Is the sky the limit? On the expansion threshold of a species’ range. Dryad. <a href=\"https://doi.org/10.5061/dryad.5vv37\">https://doi.org/10.5061/dryad.5vv37</a>","ama":"Polechova J. Data from: Is the sky the limit? On the expansion threshold of a species’ range. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>"},"related_material":{"record":[{"id":"315","status":"public","relation":"used_in_publication"}]},"publisher":"Dryad","abstract":[{"lang":"eng","text":"More than 100 years after Grigg’s influential analysis of species’ borders, the causes of limits to species’ ranges still represent a puzzle that has never been understood with clarity. The topic has become especially important recently as many scientists have become interested in the potential for species’ ranges to shift in response to climate change—and yet nearly all of those studies fail to recognise or incorporate evolutionary genetics in a way that relates to theoretical developments. I show that range margins can be understood based on just two measurable parameters: (i) the fitness cost of dispersal—a measure of environmental heterogeneity—and (ii) the strength of genetic drift, which reduces genetic diversity. Together, these two parameters define an ‘expansion threshold’: adaptation fails when genetic drift reduces genetic diversity below that required for adaptation to a heterogeneous environment. When the key parameters drop below this expansion threshold locally, a sharp range margin forms. When they drop below this threshold throughout the species’ range, adaptation collapses everywhere, resulting in either extinction or formation of a fragmented metapopulation. Because the effects of dispersal differ fundamentally with dimension, the second parameter—the strength of genetic drift—is qualitatively different compared to a linear habitat. In two-dimensional habitats, genetic drift becomes effectively independent of selection. It decreases with ‘neighbourhood size’—the number of individuals accessible by dispersal within one generation. Moreover, in contrast to earlier predictions, which neglected evolution of genetic variance and/or stochasticity in two dimensions, dispersal into small marginal populations aids adaptation. This is because the reduction of both genetic and demographic stochasticity has a stronger effect than the cost of dispersal through increased maladaptation. The expansion threshold thus provides a novel, theoretically justified, and testable prediction for formation of the range margin and collapse of the species’ range."}],"title":"Data from: Is the sky the limit? On the expansion threshold of a species' range","month":"06","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","author":[{"last_name":"Polechova","full_name":"Polechova, Jitka","orcid":"0000-0003-0951-3112","first_name":"Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"NiBa"}],"article_processing_charge":"No","day":"22","oa_version":"Published Version","year":"2019","date_published":"2019-06-22T00:00:00Z","_id":"9839","date_created":"2021-08-09T13:07:28Z"},{"date_published":"2019-04-01T00:00:00Z","_id":"6466","external_id":{"isi":["000474808300001"]},"date_created":"2019-05-19T21:59:15Z","file_date_updated":"2020-07-14T12:47:31Z","year":"2019","article_processing_charge":"No","day":"01","publication":"Molecular ecology","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","file":[{"file_name":"2019_MolecularEcology_Field.pdf","relation":"main_file","date_created":"2019-05-20T11:49:06Z","creator":"dernst","access_level":"open_access","file_size":367711,"content_type":"application/pdf","file_id":"6472","checksum":"521e3aff3e9263ddf2ffbfe0b6157715","date_updated":"2020-07-14T12:47:31Z"}],"publisher":"Wiley","quality_controlled":"1","abstract":[{"text":"One of the most striking and consistent results in speciation genomics is the heterogeneous divergence observed across the genomes of closely related species. This pattern was initially attributed to different levels of gene exchange—with divergence preserved at loci generating a barrier to gene flow but homogenized at unlinked neutral loci. Although there is evidence to support this model, it is now recognized that interpreting patterns of divergence across genomes is not so straightforward. One \r\nproblem is that heterogenous divergence between populations can also be generated by other processes (e.g. recurrent selective sweeps or background selection) without any involvement of differential gene flow. Thus, integrated studies that identify which loci are likely subject to divergent selection are required to shed light on the interplay between selection and gene flow during the early phases of speciation. In this issue of Molecular Ecology, Rifkin et al. (2019) confront this challenge using a pair of sister morning glory species. They wisely design their sampling to take the geographic context of individuals into account, including geographically isolated (allopatric) and co‐occurring (sympatric) populations. This enabled them to show that individuals are phenotypically less differentiated in sympatry. They also found that the loci that resist introgression are enriched for those most differentiated in allopatry and loci that exhibit signals of divergent selection. One great strength of the \r\nstudy is the combination of methods from population genetics and molecular evolution, including the development of a model to simultaneously infer admixture proportions and selfing rates.","lang":"eng"}],"title":"Breaking down barriers in morning glories","publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"date_updated":"2026-04-16T08:33:17Z","doi":"10.1111/mec.15048","status":"public","oa":1,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"page":"1579-1581","oa_version":"Published Version","language":[{"iso":"eng"}],"intvolume":"        28","ddc":["580","576"],"scopus_import":"1","month":"04","volume":28,"isi":1,"publication_status":"published","department":[{"_id":"NiBa"}],"author":[{"first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478","last_name":"Field","full_name":"Field, David"},{"last_name":"Fraisse","full_name":"Fraisse, Christelle","orcid":"0000-0001-8441-5075","first_name":"Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87"}],"has_accepted_license":"1","issue":"7","citation":{"short":"D. Field, C. Fraisse, Molecular Ecology 28 (2019) 1579–1581.","ama":"Field D, Fraisse C. Breaking down barriers in morning glories. <i>Molecular ecology</i>. 2019;28(7):1579-1581. doi:<a href=\"https://doi.org/10.1111/mec.15048\">10.1111/mec.15048</a>","apa":"Field, D., &#38; Fraisse, C. (2019). Breaking down barriers in morning glories. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.15048\">https://doi.org/10.1111/mec.15048</a>","ista":"Field D, Fraisse C. 2019. Breaking down barriers in morning glories. Molecular ecology. 28(7), 1579–1581.","ieee":"D. Field and C. Fraisse, “Breaking down barriers in morning glories,” <i>Molecular ecology</i>, vol. 28, no. 7. Wiley, pp. 1579–1581, 2019.","chicago":"Field, David, and Christelle Fraisse. “Breaking down Barriers in Morning Glories.” <i>Molecular Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/mec.15048\">https://doi.org/10.1111/mec.15048</a>.","mla":"Field, David, and Christelle Fraisse. “Breaking down Barriers in Morning Glories.” <i>Molecular Ecology</i>, vol. 28, no. 7, Wiley, 2019, pp. 1579–81, doi:<a href=\"https://doi.org/10.1111/mec.15048\">10.1111/mec.15048</a>."}},{"status":"public","date_updated":"2026-06-18T19:05:03Z","doi":"10.1098/rsbl.2018.0881","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"}],"oa":1,"article_type":"original","quality_controlled":"1","title":"The distribution of epistasis on simple fitness landscapes","abstract":[{"text":"Fitness interactions between mutations can influence a population’s evolution in many different ways. While epistatic effects are difficult to measure precisely, important information is captured by the mean and variance of log fitnesses for individuals carrying different numbers of mutations. We derive predictions for these quantities from a class of simple fitness landscapes, based on models of optimizing selection on quantitative traits. We also explore extensions to the models, including modular pleiotropy, variable effect sizes, mutational bias and maladaptation of the wild type. We illustrate our approach by reanalysing a large dataset of mutant effects in a yeast snoRNA (small nucleolar RNA). Though characterized by some large epistatic effects, these data give a good overall fit to the non-epistatic null model, suggesting that epistasis might have limited influence on the evolutionary dynamics in this system. We also show how the amount of epistasis depends on both the underlying fitness landscape and the distribution of mutations, and so is expected to vary in consistent ways between new mutations, standing variation and fixed mutations.","lang":"eng"}],"publisher":"Royal Society of London","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1098/rsbl.2018.0881"}],"publication_identifier":{"issn":["1744-9561"],"eissn":["1744-957X"]},"day":"03","article_processing_charge":"No","publication":"Biology Letters","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","_id":"6467","external_id":{"isi":["000465405300010"],"pmid":["31014191"]},"date_published":"2019-04-03T00:00:00Z","pmid":1,"date_created":"2019-05-19T21:59:15Z","year":"2019","related_material":{"link":[{"url":"https://dx.doi.org/10.6084/m9.figshare.c.4461008","relation":"supplementary_material"}],"record":[{"relation":"research_data","status":"public","id":"9799"},{"id":"9798","status":"public","relation":"research_data"}]},"ec_funded":1,"issue":"4","citation":{"ama":"Fraisse C, Welch JJ. The distribution of epistasis on simple fitness landscapes. <i>Biology Letters</i>. 2019;15(4). doi:<a href=\"https://doi.org/10.1098/rsbl.2018.0881\">10.1098/rsbl.2018.0881</a>","apa":"Fraisse, C., &#38; Welch, J. J. (2019). The distribution of epistasis on simple fitness landscapes. <i>Biology Letters</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rsbl.2018.0881\">https://doi.org/10.1098/rsbl.2018.0881</a>","short":"C. Fraisse, J.J. Welch, Biology Letters 15 (2019).","chicago":"Fraisse, Christelle, and John J. Welch. “The Distribution of Epistasis on Simple Fitness Landscapes.” <i>Biology Letters</i>. Royal Society of London, 2019. <a href=\"https://doi.org/10.1098/rsbl.2018.0881\">https://doi.org/10.1098/rsbl.2018.0881</a>.","ieee":"C. Fraisse and J. J. Welch, “The distribution of epistasis on simple fitness landscapes,” <i>Biology Letters</i>, vol. 15, no. 4. Royal Society of London, 2019.","mla":"Fraisse, Christelle, and John J. Welch. “The Distribution of Epistasis on Simple Fitness Landscapes.” <i>Biology Letters</i>, vol. 15, no. 4, 0881, Royal Society of London, 2019, doi:<a href=\"https://doi.org/10.1098/rsbl.2018.0881\">10.1098/rsbl.2018.0881</a>.","ista":"Fraisse C, Welch JJ. 2019. The distribution of epistasis on simple fitness landscapes. Biology Letters. 15(4), 0881."},"article_number":"0881","scopus_import":"1","intvolume":"        15","ddc":["570"],"volume":15,"month":"04","author":[{"orcid":"0000-0001-8441-5075","last_name":"Fraisse","full_name":"Fraisse, Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","first_name":"Christelle"},{"last_name":"Welch","full_name":"Welch, John J.","first_name":"John J."}],"department":[{"_id":"BeVi"},{"_id":"NiBa"}],"isi":1,"publication_status":"published","oa_version":"Published Version","language":[{"iso":"eng"}]},{"scopus_import":"1","intvolume":"        73","ddc":["576"],"acknowledgement":"The authors would like to thank to Tiago Paixao and Nick Barton for useful comments and advice.","author":[{"id":"42302D54-F248-11E8-B48F-1D18A9856A87","first_name":"Barbora","last_name":"Trubenova","full_name":"Trubenova, Barbora","orcid":"0000-0002-6873-2967"},{"last_name":"Krejca","full_name":"Krejca, Martin ","first_name":"Martin "},{"first_name":"Per Kristian","last_name":"Lehre","full_name":"Lehre, Per Kristian"},{"full_name":"Kötzing, Timo","last_name":"Kötzing","first_name":"Timo"}],"department":[{"_id":"NiBa"}],"publication_status":"published","isi":1,"month":"07","volume":73,"language":[{"iso":"eng"}],"oa_version":"Published Version","page":"1356-1374","has_accepted_license":"1","ec_funded":1,"citation":{"ista":"Trubenova B, Krejca M, Lehre PK, Kötzing T. 2019. Surfing on the seascape: Adaptation in a changing environment. Evolution. 73(7), 1356–1374.","chicago":"Trubenova, Barbora, Martin  Krejca, Per Kristian Lehre, and Timo Kötzing. “Surfing on the Seascape: Adaptation in a Changing Environment.” <i>Evolution</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/evo.13784\">https://doi.org/10.1111/evo.13784</a>.","ieee":"B. Trubenova, M. Krejca, P. K. Lehre, and T. Kötzing, “Surfing on the seascape: Adaptation in a changing environment,” <i>Evolution</i>, vol. 73, no. 7. Wiley, pp. 1356–1374, 2019.","mla":"Trubenova, Barbora, et al. “Surfing on the Seascape: Adaptation in a Changing Environment.” <i>Evolution</i>, vol. 73, no. 7, Wiley, 2019, pp. 1356–74, doi:<a href=\"https://doi.org/10.1111/evo.13784\">10.1111/evo.13784</a>.","short":"B. Trubenova, M. Krejca, P.K. Lehre, T. Kötzing, Evolution 73 (2019) 1356–1374.","ama":"Trubenova B, Krejca M, Lehre PK, Kötzing T. Surfing on the seascape: Adaptation in a changing environment. <i>Evolution</i>. 2019;73(7):1356-1374. doi:<a href=\"https://doi.org/10.1111/evo.13784\">10.1111/evo.13784</a>","apa":"Trubenova, B., Krejca, M., Lehre, P. K., &#38; Kötzing, T. (2019). Surfing on the seascape: Adaptation in a changing environment. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.13784\">https://doi.org/10.1111/evo.13784</a>"},"issue":"7","day":"01","article_processing_charge":"Yes (via OA deal)","type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Evolution","date_created":"2019-07-14T21:59:20Z","external_id":{"isi":["000474031600001"]},"_id":"6637","date_published":"2019-07-01T00:00:00Z","year":"2019","file_date_updated":"2020-07-14T12:47:34Z","doi":"10.1111/evo.13784","status":"public","date_updated":"2025-04-14T07:22:28Z","project":[{"_id":"25AEDD42-B435-11E9-9278-68D0E5697425","grant_number":"704172","name":"Rate of Adaptation in Changing Environment","call_identifier":"H2020"},{"name":"Speed of Adaptation in Population Genetics and Evolutionary Computation","grant_number":"618091","_id":"25B1EC9E-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"tmp":{"short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"article_type":"original","oa":1,"abstract":[{"lang":"eng","text":"The environment changes constantly at various time scales and, in order to survive, species need to keep adapting. Whether these species succeed in avoiding extinction is a major evolutionary question. Using a multilocus evolutionary model of a mutation‐limited population adapting under strong selection, we investigate the effects of the frequency of environmental fluctuations on adaptation. Our results rely on an “adaptive‐walk” approximation and use mathematical methods from evolutionary computation theory to investigate the interplay between fluctuation frequency, the similarity of environments, and the number of loci contributing to adaptation. First, we assume a linear additive fitness function, but later generalize our results to include several types of epistasis. We show that frequent environmental changes prevent populations from reaching a fitness peak, but they may also prevent the large fitness loss that occurs after a single environmental change. Thus, the population can survive, although not thrive, in a wide range of conditions. Furthermore, we show that in a frequently changing environment, the similarity of threats that a population faces affects the level of adaptation that it is able to achieve. We check and supplement our analytical results with simulations."}],"title":"Surfing on the seascape: Adaptation in a changing environment","quality_controlled":"1","publisher":"Wiley","file":[{"date_created":"2019-07-16T06:08:31Z","relation":"main_file","file_size":815416,"creator":"apreinsp","access_level":"open_access","file_name":"2019_Evolution_TrubenovaBarbora.pdf","date_updated":"2020-07-14T12:47:34Z","content_type":"application/pdf","checksum":"9831ca65def2d62498c7b08338b6d237","file_id":"6643"}]},{"doi":"10.1111/evo.13812","date_updated":"2024-10-09T20:58:56Z","status":"public","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"publisher":"Wiley","abstract":[{"lang":"eng","text":"This paper analyzes how partial selfing in a large source population influences its ability to colonize a new habitat via the introduction of a few founder individuals. Founders experience inbreeding depression due to partially recessive deleterious alleles as well as maladaptation to the new environment due to selection on a large number of additive loci. I first introduce a simplified version of the Inbreeding History Model (Kelly, 2007) in order to characterize mutation‐selection balance in a large, partially selfing source population under selection involving multiple non‐identical loci. I then use individual‐based simulations to study the eco‐evolutionary dynamics of founders establishing in the new habitat under a model of hard selection. The study explores how selfing rate shapes establishment probabilities of founders via effects on both inbreeding depression and adaptability to the new environment, and also distinguishes the effects of selfing on the initial fitness of founders from its effects on the long‐term adaptive response of the populations they found. A high rate of (but not complete) selfing is found to aid establishment over a wide range of parameters, even in the absence of mate limitation. The sensitivity of the results to assumptions about the nature of polygenic selection are discussed."}],"title":"Effect of partial selfing and polygenic selection on establishment in a new habitat","quality_controlled":"1","file":[{"checksum":"772ce7035965153959b946a1033de1ca","file_id":"6881","content_type":"application/pdf","date_updated":"2020-07-14T12:47:37Z","file_name":"2019_Evolution_Sachdeva.pdf","date_created":"2019-09-17T10:56:27Z","relation":"main_file","file_size":937573,"access_level":"open_access","creator":"kschuh"}],"publication_identifier":{"eissn":["1558-5646"],"issn":["0014-3820"]},"article_processing_charge":"Yes (via OA deal)","day":"01","type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Evolution","date_created":"2019-07-25T09:08:28Z","date_published":"2019-09-01T00:00:00Z","_id":"6680","external_id":{"isi":["000481300600001"]},"year":"2019","file_date_updated":"2020-07-14T12:47:37Z","has_accepted_license":"1","related_material":{"record":[{"relation":"research_data","status":"public","id":"9802"}]},"corr_author":"1","citation":{"apa":"Sachdeva, H. (2019). Effect of partial selfing and polygenic selection on establishment in a new habitat. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.13812\">https://doi.org/10.1111/evo.13812</a>","ama":"Sachdeva H. Effect of partial selfing and polygenic selection on establishment in a new habitat. <i>Evolution</i>. 2019;73(9):1729-1745. doi:<a href=\"https://doi.org/10.1111/evo.13812\">10.1111/evo.13812</a>","short":"H. Sachdeva, Evolution 73 (2019) 1729–1745.","mla":"Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on Establishment in a New Habitat.” <i>Evolution</i>, vol. 73, no. 9, Wiley, 2019, pp. 1729–45, doi:<a href=\"https://doi.org/10.1111/evo.13812\">10.1111/evo.13812</a>.","ieee":"H. Sachdeva, “Effect of partial selfing and polygenic selection on establishment in a new habitat,” <i>Evolution</i>, vol. 73, no. 9. Wiley, pp. 1729–1745, 2019.","chicago":"Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on Establishment in a New Habitat.” <i>Evolution</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/evo.13812\">https://doi.org/10.1111/evo.13812</a>.","ista":"Sachdeva H. 2019. Effect of partial selfing and polygenic selection on establishment in a new habitat. Evolution. 73(9), 1729–1745."},"issue":"9","ddc":["576"],"intvolume":"        73","scopus_import":"1","publication_status":"published","isi":1,"author":[{"full_name":"Sachdeva, Himani","last_name":"Sachdeva","id":"42377A0A-F248-11E8-B48F-1D18A9856A87","first_name":"Himani"}],"department":[{"_id":"NiBa"}],"month":"09","volume":73,"language":[{"iso":"eng"}],"page":"1729-1745","oa_version":"Published Version"},{"file":[{"date_updated":"2020-07-14T12:47:40Z","file_id":"6799","content_type":"application/pdf","checksum":"adcb70af4901977d95b8747eeee01bd7","date_created":"2019-08-12T07:30:30Z","relation":"main_file","access_level":"open_access","creator":"dernst","file_size":2839636,"file_name":"2019_EcologyEvolution_Trubenova.pdf"}],"quality_controlled":"1","abstract":[{"text":"The green‐beard effect is one proposed mechanism predicted to underpin the evolu‐tion of altruistic behavior. It relies on the recognition and the selective help of altruists to each other in order to promote and sustain altruistic behavior. However, this mechanism has often been dismissed as unlikely or uncommon, as it is assumed that both the signaling trait and altruistic trait need to be encoded by the same gene or through tightly linked genes. Here, we use models of indirect genetic effects (IGEs) to find the minimum correlation between the signaling and altruistic trait required for the evolution of the latter. We show that this correlation threshold depends on the strength of the interaction (influence of the green beard on the expression of the altruistic trait), as well as the costs and benefits of the altruistic behavior. We further show that this correlation does not necessarily have to be high and support our analytical results by simulations.","lang":"eng"}],"title":"Green beards in the light of indirect genetic effects","publisher":"Wiley","publication_identifier":{"eissn":["2045-7758"]},"date_updated":"2026-04-03T09:50:31Z","doi":"10.1002/ece3.5484","status":"public","project":[{"grant_number":"704172","name":"Rate of Adaptation in Changing Environment","_id":"25AEDD42-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"oa":1,"article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"6795","external_id":{"isi":["000479973400001"]},"date_published":"2019-09-01T00:00:00Z","date_created":"2019-08-11T21:59:24Z","file_date_updated":"2020-07-14T12:47:40Z","year":"2019","day":"01","article_processing_charge":"No","publication":"Ecology and Evolution","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","type":"journal_article","ec_funded":1,"has_accepted_license":"1","issue":"17","citation":{"short":"B. Trubenova, R. Hager, Ecology and Evolution 9 (2019) 9597–9608.","apa":"Trubenova, B., &#38; Hager, R. (2019). Green beards in the light of indirect genetic effects. <i>Ecology and Evolution</i>. Wiley. <a href=\"https://doi.org/10.1002/ece3.5484\">https://doi.org/10.1002/ece3.5484</a>","ama":"Trubenova B, Hager R. Green beards in the light of indirect genetic effects. <i>Ecology and Evolution</i>. 2019;9(17):9597-9608. doi:<a href=\"https://doi.org/10.1002/ece3.5484\">10.1002/ece3.5484</a>","ista":"Trubenova B, Hager R. 2019. Green beards in the light of indirect genetic effects. Ecology and Evolution. 9(17), 9597–9608.","mla":"Trubenova, Barbora, and Reinmar Hager. “Green Beards in the Light of Indirect Genetic Effects.” <i>Ecology and Evolution</i>, vol. 9, no. 17, Wiley, 2019, pp. 9597–608, doi:<a href=\"https://doi.org/10.1002/ece3.5484\">10.1002/ece3.5484</a>.","ieee":"B. Trubenova and R. Hager, “Green beards in the light of indirect genetic effects,” <i>Ecology and Evolution</i>, vol. 9, no. 17. Wiley, pp. 9597–9608, 2019.","chicago":"Trubenova, Barbora, and Reinmar Hager. “Green Beards in the Light of Indirect Genetic Effects.” <i>Ecology and Evolution</i>. Wiley, 2019. <a href=\"https://doi.org/10.1002/ece3.5484\">https://doi.org/10.1002/ece3.5484</a>."},"oa_version":"Published Version","page":"9597-9608","language":[{"iso":"eng"}],"scopus_import":"1","intvolume":"         9","ddc":["576"],"month":"09","volume":9,"author":[{"id":"42302D54-F248-11E8-B48F-1D18A9856A87","first_name":"Barbora","full_name":"Trubenova, Barbora","last_name":"Trubenova","orcid":"0000-0002-6873-2967"},{"first_name":"Reinmar","full_name":"Hager, Reinmar","last_name":"Hager"}],"department":[{"_id":"NiBa"}],"publication_status":"published","isi":1},{"language":[{"iso":"eng"}],"page":"1108-1120","oa_version":"Published Version","intvolume":"       224","ddc":["570"],"scopus_import":"1","publication_status":"published","isi":1,"author":[{"orcid":"0000-0001-8330-1754","full_name":"Puixeu Sala, Gemma","last_name":"Puixeu Sala","first_name":"Gemma","id":"33AB266C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Melinda","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","full_name":"Pickup, Melinda","last_name":"Pickup","orcid":"0000-0001-6118-0541"},{"last_name":"Field","full_name":"Field, David","orcid":"0000-0002-4014-8478","first_name":"David"},{"first_name":"Spencer C.H.","full_name":"Barrett, Spencer C.H.","last_name":"Barrett"}],"department":[{"_id":"NiBa"},{"_id":"BeVi"}],"volume":224,"month":"11","has_accepted_license":"1","ec_funded":1,"related_material":{"record":[{"id":"9803","status":"public","relation":"research_data"},{"relation":"dissertation_contains","id":"14058","status":"public"}]},"corr_author":"1","citation":{"ista":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Variation in sexual dimorphism in a wind-pollinated plant: The influence of geographical context and life-cycle dynamics. New Phytologist. 224(3), 1108–1120.","chicago":"Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett. “Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” <i>New Phytologist</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/nph.16050\">https://doi.org/10.1111/nph.16050</a>.","ieee":"G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Variation in sexual dimorphism in a wind-pollinated plant: The influence of geographical context and life-cycle dynamics,” <i>New Phytologist</i>, vol. 224, no. 3. Wiley, pp. 1108–1120, 2019.","mla":"Puixeu Sala, Gemma, et al. “Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” <i>New Phytologist</i>, vol. 224, no. 3, Wiley, 2019, pp. 1108–20, doi:<a href=\"https://doi.org/10.1111/nph.16050\">10.1111/nph.16050</a>.","short":"G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, New Phytologist 224 (2019) 1108–1120.","ama":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. Variation in sexual dimorphism in a wind-pollinated plant: The influence of geographical context and life-cycle dynamics. <i>New Phytologist</i>. 2019;224(3):1108-1120. doi:<a href=\"https://doi.org/10.1111/nph.16050\">10.1111/nph.16050</a>","apa":"Puixeu Sala, G., Pickup, M., Field, D., &#38; Barrett, S. C. H. (2019). Variation in sexual dimorphism in a wind-pollinated plant: The influence of geographical context and life-cycle dynamics. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16050\">https://doi.org/10.1111/nph.16050</a>"},"issue":"3","date_created":"2019-08-25T22:00:51Z","date_published":"2019-11-01T00:00:00Z","_id":"6831","external_id":{"isi":["000481376500001"]},"year":"2019","file_date_updated":"2020-07-14T12:47:42Z","article_processing_charge":"Yes (via OA deal)","day":"01","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","publication":"New Phytologist","publisher":"Wiley","quality_controlled":"1","title":"Variation in sexual dimorphism in a wind-pollinated plant: The influence of geographical context and life-cycle dynamics","abstract":[{"text":"* Understanding the mechanisms causing phenotypic differences between females and males has long fascinated evolutionary biologists. An extensive literature exists on animal sexual dimorphism but less information is known about sex differences in plants, particularly the extent of geographical variation in sexual dimorphism and its life‐cycle dynamics.\r\n* Here, we investigated patterns of genetically based sexual dimorphism in vegetative and reproductive traits of a wind‐pollinated dioecious plant, Rumex hastatulus, across three life‐cycle stages using open‐pollinated families from 30 populations spanning the geographic range and chromosomal variation (XY and XY1Y2) of the species.\r\n* The direction and degree of sexual dimorphism was highly variable among populations and life‐cycle stages. Sex‐specific differences in reproductive function explained a significant amount of temporal change in sexual dimorphism. For several traits, geographical variation in sexual dimorphism was associated with bioclimatic parameters, likely due to the differential responses of the sexes to climate. We found no systematic differences in sexual dimorphism between chromosome races.\r\n* Sex‐specific trait differences in dioecious plants largely result from a balance between sexual and natural selection on resource allocation. Our results indicate that abiotic factors associated with geographical context also play a role in modifying sexual dimorphism during the plant life‐cycle.","lang":"eng"}],"file":[{"date_updated":"2020-07-14T12:47:42Z","checksum":"6370e7567d96b7b562e77d8b89653f80","content_type":"application/pdf","file_id":"6833","access_level":"open_access","creator":"apreinsp","file_size":2314016,"date_created":"2019-08-27T12:44:54Z","relation":"main_file","file_name":"2019_NewPhytologist_Puixeu.pdf"}],"publication_identifier":{"eissn":["1469-8137"]},"project":[{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"status":"public","doi":"10.1111/nph.16050","date_updated":"2026-04-07T13:25:33Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","oa":1},{"date_created":"2019-09-07T14:28:29Z","pmid":1,"date_published":"2019-07-05T00:00:00Z","_id":"6855","external_id":{"pmid":["31283361"],"isi":["000485148400020"]},"year":"2019","file_date_updated":"2020-07-14T12:47:42Z","article_processing_charge":"No","day":"05","type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"Annual Review of Genomics and Human Genetics","publisher":"Annual Reviews","title":"Thinking about the evolution of complex traits in the era of genome-wide association studies","abstract":[{"lang":"eng","text":"Many traits of interest are highly heritable and genetically complex, meaning that much of the variation they exhibit arises from differences at numerous loci in the genome. Complex traits and their evolution have been studied for more than a century, but only in the last decade have genome-wide association studies (GWASs) in humans begun to reveal their genetic basis. Here, we bring these threads of research together to ask how findings from GWASs can further our understanding of the processes that give rise to heritable variation in complex traits and of the genetic basis of complex trait evolution in response to changing selection pressures (i.e., of polygenic adaptation). Conversely, we ask how evolutionary thinking helps us to interpret findings from GWASs and informs related efforts of practical importance."}],"quality_controlled":"1","file":[{"date_updated":"2020-07-14T12:47:42Z","checksum":"23d3978cf4739a89ce2c3e779f9305ca","content_type":"application/pdf","file_id":"6862","relation":"main_file","date_created":"2019-09-09T07:22:12Z","file_size":411491,"creator":"dernst","access_level":"open_access","file_name":"2019_AnnualReview_Sella.pdf"}],"publication_identifier":{"issn":["1527-8204"],"eissn":["1545-293X"]},"doi":"10.1146/annurev-genom-083115-022316","status":"public","date_updated":"2024-10-09T20:58:59Z","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"language":[{"iso":"eng"}],"page":"461-493","oa_version":"Published Version","ddc":["576"],"intvolume":"        20","scopus_import":"1","publication_status":"published","isi":1,"department":[{"_id":"NiBa"}],"author":[{"last_name":"Sella","full_name":"Sella, Guy","first_name":"Guy"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"volume":20,"month":"07","has_accepted_license":"1","corr_author":"1","citation":{"apa":"Sella, G., &#38; Barton, N. H. (2019). Thinking about the evolution of complex traits in the era of genome-wide association studies. <i>Annual Review of Genomics and Human Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genom-083115-022316\">https://doi.org/10.1146/annurev-genom-083115-022316</a>","ama":"Sella G, Barton NH. Thinking about the evolution of complex traits in the era of genome-wide association studies. <i>Annual Review of Genomics and Human Genetics</i>. 2019;20:461-493. doi:<a href=\"https://doi.org/10.1146/annurev-genom-083115-022316\">10.1146/annurev-genom-083115-022316</a>","short":"G. Sella, N.H. Barton, Annual Review of Genomics and Human Genetics 20 (2019) 461–493.","mla":"Sella, Guy, and Nicholas H. Barton. “Thinking about the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.” <i>Annual Review of Genomics and Human Genetics</i>, vol. 20, Annual Reviews, 2019, pp. 461–93, doi:<a href=\"https://doi.org/10.1146/annurev-genom-083115-022316\">10.1146/annurev-genom-083115-022316</a>.","chicago":"Sella, Guy, and Nicholas H Barton. “Thinking about the Evolution of Complex Traits in the Era of Genome-Wide Association Studies.” <i>Annual Review of Genomics and Human Genetics</i>. Annual Reviews, 2019. <a href=\"https://doi.org/10.1146/annurev-genom-083115-022316\">https://doi.org/10.1146/annurev-genom-083115-022316</a>.","ieee":"G. Sella and N. H. Barton, “Thinking about the evolution of complex traits in the era of genome-wide association studies,” <i>Annual Review of Genomics and Human Genetics</i>, vol. 20. Annual Reviews, pp. 461–493, 2019.","ista":"Sella G, Barton NH. 2019. Thinking about the evolution of complex traits in the era of genome-wide association studies. Annual Review of Genomics and Human Genetics. 20, 461–493."}},{"day":"01","article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","type":"journal_article","publication":"BioEssays","date_created":"2019-09-07T14:40:03Z","external_id":{"isi":["000489502000001"]},"_id":"6857","date_published":"2019-11-01T00:00:00Z","year":"2019","file_date_updated":"2020-07-14T12:47:42Z","status":"public","date_updated":"2023-08-30T06:56:26Z","doi":"10.1002/bies.201900151","article_type":"original","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"quality_controlled":"1","title":"Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna","abstract":[{"lang":"eng","text":"Gene Drives are regarded as future tools with a high potential for population control. Due to their inherent ability to overcome the rules of Mendelian inheritance, gene drives (GD) may spread genes rapidly through populations of sexually reproducing organisms. A release of organisms carrying a GD would constitute a paradigm shift in the handling of genetically modified organisms because gene drive organisms (GDO) are designed to drive their transgenes into wild populations and thereby increase the number of GDOs. The rapid development in this field and its focus on wild populations demand a prospective risk assessment with a focus on exposure related aspects. Presently, it is unclear how adequate risk management could be guaranteed to limit the spread of GDs in time and space, in order to avoid potential adverse effects in socio‐ecological systems.\r\n\r\nThe recent workshop on the “Evaluation of Spatial and Temporal Control of Gene Drives” hosted by the Institute of Safety/Security and Risk Sciences (ISR) in Vienna aimed at gaining some insight into the potential population dynamic behavior of GDs and appropriate measures of control. Scientists from France, Germany, England, and the USA discussed both topics in this meeting on April 4–5, 2019. This article summarizes results of the workshop."}],"publisher":"Wiley","file":[{"file_name":"2019_BioEssays_Giese.pdf","file_size":193248,"creator":"dernst","access_level":"open_access","relation":"main_file","date_created":"2019-10-11T06:59:26Z","file_id":"6939","checksum":"8cc7551bff70b2658f8d5630f228ee12","content_type":"application/pdf","date_updated":"2020-07-14T12:47:42Z"}],"publication_identifier":{"eissn":["1521-1878"]},"scopus_import":"1","intvolume":"        41","ddc":["570"],"author":[{"first_name":"B","full_name":"Giese, B","last_name":"Giese"},{"last_name":"Friess","full_name":"Friess, J L","first_name":"J L"},{"first_name":"M F ","full_name":"Schetelig, M F ","last_name":"Schetelig"},{"orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"},{"first_name":"Philip","last_name":"Messer","full_name":"Messer, Philip"},{"full_name":"Debarre, Florence","last_name":"Debarre","first_name":"Florence"},{"last_name":"Meimberg","full_name":"Meimberg, H","first_name":"H"},{"first_name":"N","full_name":"Windbichler, N","last_name":"Windbichler"},{"last_name":"Boete","full_name":"Boete, C","first_name":"C"}],"department":[{"_id":"NiBa"}],"publication_status":"published","isi":1,"month":"11","volume":41,"language":[{"iso":"eng"}],"oa_version":"Published Version","has_accepted_license":"1","citation":{"mla":"Giese, B., et al. “Gene Drives: Dynamics and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” <i>BioEssays</i>, vol. 41, no. 11, 1900151, Wiley, 2019, doi:<a href=\"https://doi.org/10.1002/bies.201900151\">10.1002/bies.201900151</a>.","chicago":"Giese, B, J L Friess, M F  Schetelig, Nicholas H Barton, Philip Messer, Florence Debarre, H Meimberg, N Windbichler, and C Boete. “Gene Drives: Dynamics and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” <i>BioEssays</i>. Wiley, 2019. <a href=\"https://doi.org/10.1002/bies.201900151\">https://doi.org/10.1002/bies.201900151</a>.","ieee":"B. Giese <i>et al.</i>, “Gene Drives: Dynamics and regulatory matters – A report from the workshop ‘Evaluation of spatial and temporal control of Gene Drives’, 4 – 5 April 2019, Vienna,” <i>BioEssays</i>, vol. 41, no. 11. Wiley, 2019.","ista":"Giese B, Friess JL, Schetelig MF, Barton NH, Messer P, Debarre F, Meimberg H, Windbichler N, Boete C. 2019. Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. BioEssays. 41(11), 1900151.","apa":"Giese, B., Friess, J. L., Schetelig, M. F., Barton, N. H., Messer, P., Debarre, F., … Boete, C. (2019). Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. <i>BioEssays</i>. Wiley. <a href=\"https://doi.org/10.1002/bies.201900151\">https://doi.org/10.1002/bies.201900151</a>","ama":"Giese B, Friess JL, Schetelig MF, et al. Gene Drives: Dynamics and regulatory matters – A report from the workshop “Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna. <i>BioEssays</i>. 2019;41(11). doi:<a href=\"https://doi.org/10.1002/bies.201900151\">10.1002/bies.201900151</a>","short":"B. Giese, J.L. Friess, M.F. Schetelig, N.H. Barton, P. Messer, F. Debarre, H. Meimberg, N. Windbichler, C. Boete, BioEssays 41 (2019)."},"article_number":"1900151","issue":"11"},{"scopus_import":"1","ddc":["570"],"intvolume":"         6","author":[{"last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"}],"department":[{"_id":"NiBa"}],"publication_status":"published","isi":1,"month":"03","volume":6,"language":[{"iso":"eng"}],"oa_version":"Published Version","page":"291-292","has_accepted_license":"1","citation":{"mla":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” <i>National Science Review</i>, vol. 6, no. 2, Oxford University Press, 2019, pp. 291–92, doi:<a href=\"https://doi.org/10.1093/nsr/nwy113\">10.1093/nsr/nwy113</a>.","ieee":"N. H. Barton, “Is speciation driven by cycles of mixing and isolation?,” <i>National Science Review</i>, vol. 6, no. 2. Oxford University Press, pp. 291–292, 2019.","chicago":"Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?” <i>National Science Review</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/nsr/nwy113\">https://doi.org/10.1093/nsr/nwy113</a>.","ista":"Barton NH. 2019. Is speciation driven by cycles of mixing and isolation? National Science Review. 6(2), 291–292.","apa":"Barton, N. H. (2019). Is speciation driven by cycles of mixing and isolation? <i>National Science Review</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/nsr/nwy113\">https://doi.org/10.1093/nsr/nwy113</a>","ama":"Barton NH. Is speciation driven by cycles of mixing and isolation? <i>National Science Review</i>. 2019;6(2):291-292. doi:<a href=\"https://doi.org/10.1093/nsr/nwy113\">10.1093/nsr/nwy113</a>","short":"N.H. Barton, National Science Review 6 (2019) 291–292."},"issue":"2","day":"01","article_processing_charge":"No","type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication":"National Science Review","date_created":"2019-09-07T14:43:02Z","external_id":{"isi":["000467957400025"]},"_id":"6858","date_published":"2019-03-01T00:00:00Z","year":"2019","file_date_updated":"2020-10-02T09:16:44Z","date_updated":"2023-08-29T07:51:09Z","status":"public","doi":"10.1093/nsr/nwy113","article_type":"review","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"quality_controlled":"1","title":"Is speciation driven by cycles of mixing and isolation?","publisher":"Oxford University Press","file":[{"date_updated":"2020-10-02T09:16:44Z","success":1,"checksum":"571d60fa21a568607d1fd04e119da88c","content_type":"application/pdf","file_id":"8595","relation":"main_file","date_created":"2020-10-02T09:16:44Z","creator":"dernst","file_size":106463,"access_level":"open_access","file_name":"2019_NSR_Barton.pdf"}],"publication_identifier":{"eissn":["2053-714X"],"issn":["2095-5138"]}},{"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png"},"article_type":"original","project":[{"grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"_id":"265B41B8-B435-11E9-9278-68D0E5697425","grant_number":"797747","name":"Theoretical and empirical approaches to understanding Parallel Adaptation","call_identifier":"H2020"}],"doi":"10.1126/sciadv.aav9963","status":"public","date_updated":"2025-04-14T07:44:02Z","publication_identifier":{"issn":["2375-2548"]},"file":[{"file_size":1869449,"access_level":"open_access","creator":"dernst","date_created":"2020-02-03T13:33:25Z","relation":"main_file","file_name":"2019_ScienceAdvances_Morales.pdf","date_updated":"2020-07-14T12:47:57Z","checksum":"af99a5dcdc66c6d6102051faf3be48d8","content_type":"application/pdf","file_id":"7442"}],"publisher":"AAAS","title":"Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast","abstract":[{"text":"The study of parallel ecological divergence provides important clues to the operation of natural selection. Parallel divergence often occurs in heterogeneous environments with different kinds of environmental gradients in different locations, but the genomic basis underlying this process is unknown. We investigated the genomics of rapid parallel adaptation in the marine snail Littorina saxatilis in response to two independent environmental axes (crab-predation versus wave-action and low-shore versus high-shore). Using pooled whole-genome resequencing, we show that sharing of genomic regions of high differentiation between environments is generally low but increases at smaller spatial scales. We identify different shared genomic regions of divergence for each environmental axis and show that most of these regions overlap with candidate chromosomal inversions. Several inversion regions are divergent and polymorphic across many localities. We argue that chromosomal inversions could store shared variation that fuels rapid parallel adaptation to heterogeneous environments, possibly as balanced polymorphism shared by adaptive gene flow.","lang":"eng"}],"quality_controlled":"1","publication":"Science Advances","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"journal_article","article_processing_charge":"No","day":"04","file_date_updated":"2020-07-14T12:47:57Z","year":"2019","date_published":"2019-12-04T00:00:00Z","external_id":{"pmid":["31840052"],"isi":["000505069600008"]},"_id":"7393","license":"https://creativecommons.org/licenses/by-nc/4.0/","pmid":1,"date_created":"2020-01-29T15:58:27Z","issue":"12","article_number":"eaav9963","citation":{"chicago":"Morales, Hernán E., Rui Faria, Kerstin Johannesson, Tomas Larsson, Marina Panova, Anja M Westram, and Roger K. Butlin. “Genomic Architecture of Parallel Ecological Divergence: Beyond a Single Environmental Contrast.” <i>Science Advances</i>. AAAS, 2019. <a href=\"https://doi.org/10.1126/sciadv.aav9963\">https://doi.org/10.1126/sciadv.aav9963</a>.","ieee":"H. E. Morales <i>et al.</i>, “Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast,” <i>Science Advances</i>, vol. 5, no. 12. AAAS, 2019.","mla":"Morales, Hernán E., et al. “Genomic Architecture of Parallel Ecological Divergence: Beyond a Single Environmental Contrast.” <i>Science Advances</i>, vol. 5, no. 12, eaav9963, AAAS, 2019, doi:<a href=\"https://doi.org/10.1126/sciadv.aav9963\">10.1126/sciadv.aav9963</a>.","ista":"Morales HE, Faria R, Johannesson K, Larsson T, Panova M, Westram AM, Butlin RK. 2019. Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast. Science Advances. 5(12), eaav9963.","ama":"Morales HE, Faria R, Johannesson K, et al. Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast. <i>Science Advances</i>. 2019;5(12). doi:<a href=\"https://doi.org/10.1126/sciadv.aav9963\">10.1126/sciadv.aav9963</a>","apa":"Morales, H. E., Faria, R., Johannesson, K., Larsson, T., Panova, M., Westram, A. M., &#38; Butlin, R. K. (2019). Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.aav9963\">https://doi.org/10.1126/sciadv.aav9963</a>","short":"H.E. Morales, R. Faria, K. Johannesson, T. Larsson, M. Panova, A.M. Westram, R.K. Butlin, Science Advances 5 (2019)."},"ec_funded":1,"has_accepted_license":"1","volume":5,"month":"12","isi":1,"publication_status":"published","author":[{"last_name":"Morales","full_name":"Morales, Hernán E.","first_name":"Hernán E."},{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"first_name":"Kerstin","full_name":"Johannesson, Kerstin","last_name":"Johannesson"},{"first_name":"Tomas","last_name":"Larsson","full_name":"Larsson, Tomas"},{"first_name":"Marina","last_name":"Panova","full_name":"Panova, Marina"},{"last_name":"Westram","full_name":"Westram, Anja M","orcid":"0000-0003-1050-4969","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roger K.","full_name":"Butlin, Roger K.","last_name":"Butlin"}],"department":[{"_id":"NiBa"}],"ddc":["570"],"intvolume":"         5","scopus_import":"1","oa_version":"Published Version","language":[{"iso":"eng"}]},{"citation":{"ista":"Andalo C, Burrus M, Paute S, Lauzeral C, Field D. 2019. Prevalence of legitimate pollinators and nectar robbers and the consequences for fruit set in an Antirrhinum majus hybrid zone. Botany Letters. 166(1), 80–92.","mla":"Andalo, Christophe, et al. “Prevalence of Legitimate Pollinators and Nectar Robbers and the Consequences for Fruit Set in an Antirrhinum Majus Hybrid Zone.” <i>Botany Letters</i>, vol. 166, no. 1, Taylor &#38; Francis, 2019, pp. 80–92, doi:<a href=\"https://doi.org/10.1080/23818107.2018.1545142\">10.1080/23818107.2018.1545142</a>.","chicago":"Andalo, Christophe, Monique Burrus, Sandrine Paute, Christine Lauzeral, and David Field. “Prevalence of Legitimate Pollinators and Nectar Robbers and the Consequences for Fruit Set in an Antirrhinum Majus Hybrid Zone.” <i>Botany Letters</i>. Taylor &#38; Francis, 2019. <a href=\"https://doi.org/10.1080/23818107.2018.1545142\">https://doi.org/10.1080/23818107.2018.1545142</a>.","ieee":"C. Andalo, M. Burrus, S. Paute, C. Lauzeral, and D. Field, “Prevalence of legitimate pollinators and nectar robbers and the consequences for fruit set in an Antirrhinum majus hybrid zone,” <i>Botany Letters</i>, vol. 166, no. 1. Taylor &#38; Francis, pp. 80–92, 2019.","short":"C. Andalo, M. Burrus, S. Paute, C. Lauzeral, D. Field, Botany Letters 166 (2019) 80–92.","apa":"Andalo, C., Burrus, M., Paute, S., Lauzeral, C., &#38; Field, D. (2019). Prevalence of legitimate pollinators and nectar robbers and the consequences for fruit set in an Antirrhinum majus hybrid zone. <i>Botany Letters</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.1080/23818107.2018.1545142\">https://doi.org/10.1080/23818107.2018.1545142</a>","ama":"Andalo C, Burrus M, Paute S, Lauzeral C, Field D. Prevalence of legitimate pollinators and nectar robbers and the consequences for fruit set in an Antirrhinum majus hybrid zone. <i>Botany Letters</i>. 2019;166(1):80-92. doi:<a href=\"https://doi.org/10.1080/23818107.2018.1545142\">10.1080/23818107.2018.1545142</a>"},"issue":"1","das_tickbox":"1","language":[{"iso":"eng"}],"oa_version":"None","page":"80-92","department":[{"_id":"NiBa"}],"author":[{"last_name":"Andalo","full_name":"Andalo, Christophe","first_name":"Christophe"},{"first_name":"Monique","last_name":"Burrus","full_name":"Burrus, Monique"},{"first_name":"Sandrine","last_name":"Paute","full_name":"Paute, Sandrine"},{"first_name":"Christine","last_name":"Lauzeral","full_name":"Lauzeral, Christine"},{"orcid":"0000-0002-4014-8478","last_name":"Field","full_name":"Field, David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","first_name":"David"}],"isi":1,"publication_status":"published","month":"01","volume":166,"scopus_import":"1","intvolume":"       166","publication_identifier":{"eissn":["2381-8115"],"issn":["2381-8107"]},"abstract":[{"text":"Pollinators display a remarkable diversity of foraging strategies with flowering plants, from primarily mutualistic interactions to cheating through nectar robbery. Despite numerous studies on the effect of nectar robbing on components of plant fitness, its contribution to reproductive isolation is unclear. We experimentally tested the impact of different pollinator strategies in a natural hybrid zone between two subspecies of Antirrhinum majus with alternate flower colour guides. On either side of a steep cline in flower colour between Antirrhinum majus pseudomajus (magenta) and A. m. striatum (yellow), we quantified the behaviour of all floral visitors at different time points during the flowering season. Using long-run camera surveys, we quantify the impact of nectar robbing on the number of flowers visited per inflorescence and the flower probing time. We further experimentally tested the effect of nectar robbing on female reproductive success by manipulating the intensity of robbing. While robbing increased over time the number of legitimate visitors tended to decrease concomitantly. We found that the number of flowers pollinated on a focal inflorescence decreased with the number of prior robbing events. However, in the manipulative experiment, fruit set and fruit volume did not vary significantly between low robbing and control treatments. Our findings challenge the idea that robbers have a negative impact on plant fitness through female function. This study also adds to our understanding of the components of pollinator-mediated reproductive isolation and the maintenance of Antirrhinum hybrid zones.","lang":"eng"}],"title":"Prevalence of legitimate pollinators and nectar robbers and the consequences for fruit set in an Antirrhinum majus hybrid zone","quality_controlled":"1","publisher":"Taylor & Francis","status":"public","doi":"10.1080/23818107.2018.1545142","date_updated":"2026-07-07T05:33:54Z","year":"2019","date_created":"2018-12-16T22:59:20Z","external_id":{"isi":["000463802800009"]},"_id":"5680","date_published":"2019-01-01T00:00:00Z","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Botany Letters","day":"01","article_processing_charge":"No"}]