[{"oa":1,"file_date_updated":"2021-02-22T13:42:47Z","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-07-29T11:27:43Z","month":"07","language":[{"iso":"eng"}],"date_published":"2016-07-01T00:00:00Z","type":"dissertation","oa_version":"Published Version","_id":"1125","publist_id":"6235","citation":{"chicago":"Novak, Sebastian. “Evolutionary Proccesses in Variable Emvironments.” Institute of Science and Technology Austria, 2016.","apa":"Novak, S. (2016). <i>Evolutionary proccesses in variable emvironments</i>. Institute of Science and Technology Austria.","mla":"Novak, Sebastian. <i>Evolutionary Proccesses in Variable Emvironments</i>. Institute of Science and Technology Austria, 2016.","ieee":"S. Novak, “Evolutionary proccesses in variable emvironments,” Institute of Science and Technology Austria, 2016.","short":"S. Novak, Evolutionary Proccesses in Variable Emvironments, Institute of Science and Technology Austria, 2016.","ista":"Novak S. 2016. Evolutionary proccesses in variable emvironments. Institute of Science and Technology Austria.","ama":"Novak S. Evolutionary proccesses in variable emvironments. 2016."},"status":"public","day":"01","alternative_title":["ISTA Thesis"],"abstract":[{"lang":"eng","text":"Natural environments are never constant but subject to spatial and temporal change on\r\nall scales, increasingly so due to human activity. Hence, it is crucial to understand the\r\nimpact of environmental variation on evolutionary processes. In this thesis, I present\r\nthree topics that share the common theme of environmental variation, yet illustrate its\r\neffect from different perspectives.\r\nFirst, I show how a temporally fluctuating environment gives rise to second-order\r\nselection on a modifier for stress-induced mutagenesis. Without fluctuations, when\r\npopulations are adapted to their environment, mutation rates are minimized. I argue\r\nthat a stress-induced mutator mechanism may only be maintained if the population is\r\nrepeatedly subjected to diverse environmental challenges, and I outline implications of\r\nthe presented results to antibiotic treatment strategies.\r\nSecond, I discuss my work on the evolution of dispersal. Besides reproducing\r\nknown results about the effect of heterogeneous habitats on dispersal, it identifies\r\nspatial changes in dispersal type frequencies as a source for selection for increased\r\npropensities to disperse. This concept contains effects of relatedness that are known\r\nto promote dispersal, and I explain how it identifies other forces selecting for dispersal\r\nand puts them on a common scale.\r\nThird, I analyse genetic variances of phenotypic traits under multivariate stabilizing\r\nselection. For the case of constant environments, I generalize known formulae of\r\nequilibrium variances to multiple traits and discuss how the genetic variance of a focal\r\ntrait is influenced by selection on background traits. I conclude by presenting ideas and\r\npreliminary work aiming at including environmental fluctuations in the form of moving\r\ntrait optima into the model."}],"publication_status":"published","page":"124","article_processing_charge":"No","degree_awarded":"PhD","title":"Evolutionary proccesses in variable emvironments","doi_confirm":"1","supervisor":[{"first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"}],"OA_place":"publisher","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","author":[{"last_name":"Novak","first_name":"Sebastian","full_name":"Novak, Sebastian","id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X"}],"related_material":{"record":[{"status":"public","id":"2023","relation":"part_of_dissertation"}]},"file":[{"file_name":"Novak_thesis.pdf","content_type":"application/pdf","date_created":"2019-08-13T09:01:00Z","creator":"dernst","file_id":"6811","date_updated":"2019-08-13T09:01:00Z","file_size":3564901,"relation":"main_file","checksum":"81dcc838dfcf7aa0b1a27ecf4fe2da4e","access_level":"closed"},{"creator":"dernst","success":1,"date_created":"2021-02-22T13:42:47Z","file_name":"2016_Novak_Thesis.pdf","content_type":"application/pdf","relation":"main_file","checksum":"30808d2f7ca920e09f63a95cdc49bffd","access_level":"open_access","file_size":2814384,"date_updated":"2021-02-22T13:42:47Z","file_id":"9186"}],"corr_author":"1","ddc":["576"],"has_accepted_license":"1","year":"2016","date_created":"2018-12-11T11:50:17Z","publication_identifier":{"issn":["2663-337X"]}},{"publist_id":"6229","_id":"1131","oa_version":"Published Version","type":"dissertation","acknowledgement":"This PhD thesis may not have been completed without the help and care I received from some peo- ple during my PhD life. I am especially grateful to Tiago Paixao, Gasper Tkacik, Nick Barton, not only for their scientific advices but also for their patience and support. I thank Calin Guet and Jonathan Bollback for allowing me to “play around” in their labs and get some experience on experimental evolution. I thank Magdalena Steinrueck and Fabienne Jesse for collaborating and sharing their experimental data with me. I thank Johannes Jaeger for reviewing my thesis. I thank all members of Barton group (aka bartonians) for their feedback, and all workers of IST Austria for making the best working conditions. Lastly, I thank two special women, Nejla Sag ̆lam and Setenay Dog ̆an, for their continuous support and encouragement. I truly had a great chance of having right people around me.","date_published":"2016-07-01T00:00:00Z","language":[{"iso":"eng"}],"month":"07","date_updated":"2026-07-29T11:31:14Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"file_date_updated":"2021-02-22T11:45:20Z","oa":1,"alternative_title":["ISTA Thesis"],"day":"01","status":"public","citation":{"mla":"Tugrul, Murat. <i>Evolution of Transcriptional Regulatory Sequences</i>. Institute of Science and Technology Austria, 2016.","chicago":"Tugrul, Murat. “Evolution of Transcriptional Regulatory Sequences.” Institute of Science and Technology Austria, 2016.","apa":"Tugrul, M. (2016). <i>Evolution of transcriptional regulatory sequences</i>. Institute of Science and Technology Austria.","ista":"Tugrul M. 2016. Evolution of transcriptional regulatory sequences. Institute of Science and Technology Austria.","ama":"Tugrul M. Evolution of transcriptional regulatory sequences. 2016.","short":"M. Tugrul, Evolution of Transcriptional Regulatory Sequences, Institute of Science and Technology Austria, 2016.","ieee":"M. Tugrul, “Evolution of transcriptional regulatory sequences,” Institute of Science and Technology Austria, 2016."},"related_material":{"record":[{"status":"public","relation":"research_data","id":"5554"},{"relation":"part_of_dissertation","id":"1666","status":"public"}]},"author":[{"full_name":"Tugrul, Murat","id":"37C323C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8523-0758","first_name":"Murat","last_name":"Tugrul"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_place":"publisher","supervisor":[{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"}],"doi_confirm":"1","degree_awarded":"PhD","title":"Evolution of transcriptional regulatory sequences","article_processing_charge":"No","page":"89","publication_status":"published","abstract":[{"lang":"eng","text":"Evolution of gene regulation is important for phenotypic evolution and diversity. Sequence-specific binding of regulatory proteins is one of the key regulatory mechanisms determining gene expression. Although there has been intense interest in evolution of regulatory binding sites in the last decades, a theoretical understanding is far from being complete. In this thesis, I aim at a better understanding of the evolution of transcriptional regulatory binding sequences by using biophysical and population genetic models.\r\nIn the first part of the thesis, I discuss how to formulate the evolutionary dynamics of binding se- quences in a single isolated binding site and in promoter/enhancer regions. I develop a theoretical framework bridging between a thermodynamical model for transcription and a mutation-selection-drift model for monomorphic populations. I mainly address the typical evolutionary rates, and how they de- pend on biophysical parameters (e.g. binding length and specificity) and population genetic parameters (e.g. population size and selection strength).\r\nIn the second part of the thesis, I analyse empirical data for a better evolutionary and biophysical understanding of sequence-specific binding of bacterial RNA polymerase. First, I infer selection on regulatory and non-regulatory binding sites of RNA polymerase in the E. coli K12 genome. Second, I infer the chemical potential of RNA polymerase, an important but unknown physical parameter defining the threshold energy for strong binding. Furthermore, I try to understand the relation between the lac promoter sequence diversity and the LacZ activity variation among 20 bacterial isolates by constructing a simple but biophysically motivated gene expression model. Lastly, I lay out a statistical framework to predict adaptive point mutations in de novo promoter evolution in a selection experiment."}],"publication_identifier":{"issn":["2663-337X"]},"date_created":"2018-12-11T11:50:19Z","year":"2016","has_accepted_license":"1","ddc":["576"],"corr_author":"1","file":[{"creator":"dernst","date_created":"2019-08-13T08:53:52Z","file_name":"Tugrul_thesis_w_signature_page.pdf","content_type":"application/pdf","relation":"main_file","checksum":"66cb61a59943e4fb7447c6a86be5ef51","access_level":"closed","file_size":3695257,"date_updated":"2019-08-13T08:53:52Z","file_id":"6810"},{"file_name":"2016_Tugrul_Thesis.pdf","content_type":"application/pdf","date_created":"2021-02-22T11:45:20Z","success":1,"creator":"dernst","file_id":"9182","date_updated":"2021-02-22T11:45:20Z","file_size":3880811,"access_level":"open_access","checksum":"293e388d70563760f6b24c3e66283dda","relation":"main_file"}]},{"article_processing_charge":"No","license":"https://creativecommons.org/publicdomain/zero/1.0/","file_date_updated":"2020-07-14T12:47:01Z","abstract":[{"lang":"eng","text":"The data stored here is used in Murat Tugrul's PhD thesis (Chapter 3), which is related to the evolution of bacterial RNA polymerase binding.\r\nMagdalena Steinrueck (PhD Student in Calin Guet's group at IST Austria) performed the experiments and created the data on de novo promoter evolution. Fabienne Jesse (PhD Student in Jon Bollback's group at IST Austria) performed the experiments and created the data on lac promoter evolution."}],"oa":1,"keyword":["RNAP binding","de novo promoter evolution","lac promoter"],"date_published":"2016-05-12T00:00:00Z","month":"05","title":"Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase","date_updated":"2026-07-29T11:31:13Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"NiBa"},{"_id":"JoBo"}],"oa_version":"Published Version","author":[{"orcid":"0000-0002-8523-0758","id":"37C323C6-F248-11E8-B48F-1D18A9856A87","full_name":"Tugrul, Murat","last_name":"Tugrul","first_name":"Murat"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"research_data","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"1131"}]},"_id":"5554","citation":{"ieee":"M. Tugrul, “Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase.” Institute of Science and Technology Austria, 2016.","short":"M. Tugrul, (2016).","ama":"Tugrul M. Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:43\">10.15479/AT:ISTA:43</a>","ista":"Tugrul M. 2016. Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:43\">10.15479/AT:ISTA:43</a>.","chicago":"Tugrul, Murat. “Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:43\">https://doi.org/10.15479/AT:ISTA:43</a>.","apa":"Tugrul, M. (2016). Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:43\">https://doi.org/10.15479/AT:ISTA:43</a>","mla":"Tugrul, Murat. <i>Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase</i>. Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:43\">10.15479/AT:ISTA:43</a>."},"file":[{"creator":"system","file_name":"IST-2016-43-v1+1_DATA_MTugrul_PhDThesis_Chapter3.zip","content_type":"application/zip","date_created":"2018-12-12T13:03:08Z","date_updated":"2020-07-14T12:47:01Z","file_size":1123495,"checksum":"1fc0a10bb7ce110fcb5e1fbe3cf0c4e2","relation":"main_file","access_level":"open_access","file_id":"5626"}],"has_accepted_license":"1","datarep_id":"43","date_created":"2018-12-12T12:31:30Z","year":"2016","contributor":[{"id":"2C023F40-F248-11E8-B48F-1D18A9856A87","first_name":"Magdalena","contributor_type":"researcher","last_name":"Steinrück"},{"first_name":"Fabienne","contributor_type":"researcher","last_name":"Jesse","id":"4C8C26A4-F248-11E8-B48F-1D18A9856A87"}],"tmp":{"legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"doi":"10.15479/AT:ISTA:43","status":"public","day":"12"},{"citation":{"mla":"Ellis, Thomas. <i>The Role of Pollinator-Mediated Selection in the Maintenance of a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone</i>. Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_526 \">10.15479/AT:ISTA:TH_526 </a>.","apa":"Ellis, T. (2016). <i>The role of pollinator-mediated selection in the maintenance of a flower color polymorphism in an Antirrhinum majus hybrid zone</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_526 \">https://doi.org/10.15479/AT:ISTA:TH_526 </a>","chicago":"Ellis, Thomas. “The Role of Pollinator-Mediated Selection in the Maintenance of a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_526 \">https://doi.org/10.15479/AT:ISTA:TH_526 </a>.","ista":"Ellis T. 2016. The role of pollinator-mediated selection in the maintenance of a flower color polymorphism in an Antirrhinum majus hybrid zone. Institute of Science and Technology Austria.","ama":"Ellis T. The role of pollinator-mediated selection in the maintenance of a flower color polymorphism in an Antirrhinum majus hybrid zone. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_526 \">10.15479/AT:ISTA:TH_526 </a>","ieee":"T. Ellis, “The role of pollinator-mediated selection in the maintenance of a flower color polymorphism in an Antirrhinum majus hybrid zone,” Institute of Science and Technology Austria, 2016.","short":"T. Ellis, The Role of Pollinator-Mediated Selection in the Maintenance of a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone, Institute of Science and Technology Austria, 2016."},"alternative_title":["ISTA Thesis"],"day":"18","pubrep_id":"526","status":"public","language":[{"iso":"eng"}],"month":"02","date_published":"2016-02-18T00:00:00Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"date_updated":"2026-07-30T14:56:14Z","oa":1,"file_date_updated":"2025-07-03T06:24:39Z","publist_id":"5809","_id":"1398","oa_version":"Published Version","acknowledgement":"I am indebted to many people for their support during my PhD, but I particularly wish to thank Nick Barton for his guidance and intuition, and for encouraging me to take the time to look beyond the immediate topic of my PhD to understand the broader context. I am also especially grateful to David Field his bottomless patience, invaluable advice on experimental design, analysis and scientific writing, and for tireless work on the population surveys and genomic work without most of my thesis could not have happened. \r\n\r\nIt has been a pleasure to work with the combined strengths of the groups at The John Innes Centre, University of Toulouse and IST Austria. Thanks to Enrico Coen and his group for hosting me in Norwich in 2011 and especially for setting up the tag experiment. \r\n\r\nI thank David Field, Desmond Bradley and Maria Clara Melo-Hurtado for organising field collections, as well as Monique Burrus and Christophe Andalo and a large number of volunteers for their e ff orts helping with the field work. Furthermore I thank Coline Jaworski for providing seeds and for her input into the design of the experimental arrays, and Matthew Couchman for maintaining the database of. \r\n\r\nIn addition to those mentioned above, I am grateful to Melinda Pickup, Spencer Barrett, and four anonymous reviewers for their insightful comments on sections of this manuscript. I also thank Jana Porsche for her e ff orts in tracking down the more obscure references for chapter 5, and Jon Bollback for his advice about the analysis. \r\n\r\nI am indebted to Jon Ågren for his patience whilst I finished this thesis, and to Sylvia Cremer and Magnus Nordborg for taking the time to read and evaluate the thesis given a shorter deadline than was fair. \r\n\r\nA very positive aspect of my PhD has been the supportive atmosphere of IST. In particular, I have come to appreciate the enormous support from our group assistants Nicole Hotzy, Julia Asimakis, Christine Ostermann and Jerneja Beslagic. I also thank Christian Chaloupka and Stefan Hipfinger for their enthusiasm and readiness to help where possible in setting up our greenhouse and experiments. ","type":"dissertation","has_accepted_license":"1","ddc":["576"],"corr_author":"1","file":[{"file_name":"2016_Thesis_Ellis_noSignatures.pdf","content_type":"application/pdf","date_created":"2025-07-03T06:24:17Z","creator":"dernst","file_id":"19957","file_size":7590862,"date_updated":"2025-07-03T06:24:17Z","checksum":"f0f7c260e19ec1416824b165afe2d5fd","relation":"main_file","access_level":"open_access"},{"file_id":"5106","checksum":"a89b17ff27cf92c9a15f6b3d46bd7e53","relation":"main_file","access_level":"closed","file_size":11928241,"date_updated":"2025-07-03T06:24:39Z","date_created":"2018-12-12T10:14:51Z","content_type":"application/pdf","file_name":"IST-2016-526-v1+1_Ellis_signed_thesis.pdf","creator":"system"}],"doi":"10.15479/AT:ISTA:TH_526 ","publication_identifier":{"issn":["2663-337X"]},"year":"2016","date_created":"2018-12-11T11:51:47Z","title":"The role of pollinator-mediated selection in the maintenance of a flower color polymorphism in an Antirrhinum majus hybrid zone","degree_awarded":"PhD","supervisor":[{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton"}],"doi_confirm":"1","page":"130","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Hybrid zones represent evolutionary laboratories, where recombination brings together alleles in combinations which have not previously been tested by selection. This provides an excellent opportunity to test the effect of molecular variation on fitness, and how this variation is able to spread through populations in a natural context. The snapdragon Antirrhinum majus is polymorphic in the wild for two loci controlling the distribution of yellow and magenta floral pigments. Where the yellow A. m. striatum and the magenta A. m. pseudomajus meet along a valley in the Spanish Pyrenees they form a stable hybrid zone Alleles at these loci recombine to give striking transgressive variation for flower colour. The sharp transition in phenotype over ~1km implies strong selection maintaining the hybrid zone. An indirect assay of pollinator visitation in the field found that pollinators forage in a positive-frequency dependent manner on Antirrhinum, matching previous data on fruit set. Experimental arrays and paternity analysis of wild-pollinated seeds demonstrated assortative mating for pigmentation alleles, and that pollinator behaviour alone is sufficient to explain this pattern. Selection by pollinators should be sufficiently strong to maintain the hybrid zone, although other mechanisms may be at work. At a broader scale I examined evolutionary transitions between yellow and anthocyanin pigmentation in the tribe Antirrhinae, and found that selection has acted strate that pollinators are a major determinant of reproductive success and mating patterns in wild Antirrhinum."}],"publication_status":"published","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"5553"},{"relation":"part_of_dissertation","id":"5551","status":"public"},{"relation":"part_of_dissertation","id":"5552","status":"public"}]},"author":[{"orcid":"0000-0002-8511-0254","id":"3153D6D4-F248-11E8-B48F-1D18A9856A87","full_name":"Ellis, Thomas","first_name":"Thomas","last_name":"Ellis"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","OA_place":"publisher"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478","full_name":"Field, David","first_name":"David","last_name":"Field"},{"full_name":"Ellis, Thomas","orcid":"0000-0002-8511-0254","id":"3153D6D4-F248-11E8-B48F-1D18A9856A87","last_name":"Ellis","first_name":"Thomas"}],"oa_version":"Published Version","type":"research_data","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"1398"}]},"_id":"5553","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Genotypic, phenotypic and demographic data for 2128 wild snapdragons and 1127 open-pollinated progeny from a natural hybrid zone, collected as part of Tom Ellis' PhD thesis (submitted) February 2016).\r\n\r\nTissue samples were sent to LGC Genomics in Berlin for DNA extraction, and genotyping at 70 SNP markers by KASPR genotyping. 29 of these SNPs failed to amplify reliably, and have been removed from this dataset.\r\n\r\nOther data were retreived from an online database of this population at www.antspec.org."}],"oa":1,"file_date_updated":"2020-07-14T12:47:01Z","month":"02","title":"Inference of mating patterns among wild snapdragons in a natural hybrid zone in 2012","keyword":["paternity assignment","pedigree","matting patterns","assortative mating","Antirrhinum majus","frequency-dependent selection","plant-pollinator interaction"],"date_published":"2016-02-19T00:00:00Z","department":[{"_id":"NiBa"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-07-30T14:56:13Z","year":"2016","date_created":"2018-12-12T12:31:30Z","datarep_id":"37","tmp":{"legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"contributor":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","contributor_type":"project_manager","last_name":"Barton"}],"doi":"10.15479/AT:ISTA:37","status":"public","day":"19","citation":{"chicago":"Field, David, and Thomas Ellis. “Inference of Mating Patterns among Wild Snapdragons in a Natural Hybrid Zone in 2012.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:37\">https://doi.org/10.15479/AT:ISTA:37</a>.","apa":"Field, D., &#38; Ellis, T. (2016). Inference of mating patterns among wild snapdragons in a natural hybrid zone in 2012. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:37\">https://doi.org/10.15479/AT:ISTA:37</a>","mla":"Field, David, and Thomas Ellis. <i>Inference of Mating Patterns among Wild Snapdragons in a Natural Hybrid Zone in 2012</i>. Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:37\">10.15479/AT:ISTA:37</a>.","short":"D. Field, T. Ellis, (2016).","ieee":"D. Field and T. Ellis, “Inference of mating patterns among wild snapdragons in a natural hybrid zone in 2012.” Institute of Science and Technology Austria, 2016.","ista":"Field D, Ellis T. 2016. Inference of mating patterns among wild snapdragons in a natural hybrid zone in 2012, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:37\">10.15479/AT:ISTA:37</a>.","ama":"Field D, Ellis T. Inference of mating patterns among wild snapdragons in a natural hybrid zone in 2012. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:37\">10.15479/AT:ISTA:37</a>"},"file":[{"file_size":132808,"date_updated":"2020-07-14T12:47:01Z","relation":"main_file","checksum":"4ae751b1fa4897fa216241f975a57313","access_level":"open_access","file_id":"5620","creator":"system","content_type":"application/zip","file_name":"IST-2016-37-v1+1_paternity_archive.zip","date_created":"2018-12-12T13:03:02Z"}],"has_accepted_license":"1","ddc":["576"]},{"has_accepted_license":"1","file":[{"date_created":"2018-12-12T13:05:12Z","content_type":"application/zip","file_name":"IST-2016-35-v1+1_array_data.zip","creator":"system","file_id":"5640","access_level":"open_access","relation":"main_file","checksum":"aa3eb85d52b110cd192aa23147c4d4f3","file_size":32775,"date_updated":"2020-07-14T12:47:01Z"}],"citation":{"short":"T. Ellis, (2016).","ieee":"T. Ellis, “Data on pollinator observations and offpsring phenotypes.” Institute of Science and Technology Austria, 2016.","ama":"Ellis T. Data on pollinator observations and offpsring phenotypes. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:35\">10.15479/AT:ISTA:35</a>","ista":"Ellis T. 2016. Data on pollinator observations and offpsring phenotypes, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:35\">10.15479/AT:ISTA:35</a>.","apa":"Ellis, T. (2016). Data on pollinator observations and offpsring phenotypes. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:35\">https://doi.org/10.15479/AT:ISTA:35</a>","chicago":"Ellis, Thomas. “Data on Pollinator Observations and Offpsring Phenotypes.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:35\">https://doi.org/10.15479/AT:ISTA:35</a>.","mla":"Ellis, Thomas. <i>Data on Pollinator Observations and Offpsring Phenotypes</i>. Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:35\">10.15479/AT:ISTA:35</a>."},"status":"public","day":"19","doi":"10.15479/AT:ISTA:35","contributor":[{"id":"419049E2-F248-11E8-B48F-1D18A9856A87","last_name":"Field","first_name":"David"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H"}],"tmp":{"legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"datarep_id":"35","date_created":"2018-12-12T12:31:29Z","year":"2016","date_updated":"2026-07-30T14:56:13Z","publisher":"Institute of Science and Technology Austria","department":[{"_id":"NiBa"}],"date_published":"2016-02-19T00:00:00Z","title":"Data on pollinator observations and offpsring phenotypes","month":"02","file_date_updated":"2020-07-14T12:47:01Z","oa":1,"abstract":[{"lang":"eng","text":"Data from array experiments investigating pollinator behaviour on snapdragons in controlled conditions, and their effect on plant mating. Data were collected as part of Tom Ellis' PhD thesis , submitted February 2016.\r\n\r\nWe placed a total of 36 plants in a grid inside a closed organza tent, with a single hive of commercially bred bumblebees (Bombus hortorum). We used only the yellow-flowered Antirrhinum majus striatum and the magenta-flowered Antirrhinum majus pseudomajus, at ratios of 6:36, 12:24, 18:18, 24:12 and 30:6.\r\n\r\nAfter 24 hours to learn how to deal with snapdragons, I observed pollinators foraging on plants, and recorded the transitions between plants. Thereafter seeds on plants were allowed to develops. A sample of these were grown to maturity when their flower colour could be determined, and they were scored as yellow, magenta, or hybrid."}],"article_processing_charge":"No","related_material":{"record":[{"relation":"dissertation_contains","id":"1398","status":"public"}]},"_id":"5551","type":"research_data","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","author":[{"first_name":"Thomas","last_name":"Ellis","full_name":"Ellis, Thomas","orcid":"0000-0002-8511-0254","id":"3153D6D4-F248-11E8-B48F-1D18A9856A87"}]},{"doi":"10.15479/AT:ISTA:36","day":"19","status":"public","year":"2016","date_created":"2018-12-12T12:31:30Z","datarep_id":"36","contributor":[{"first_name":"David","last_name":"Field","id":"419049E2-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"}],"has_accepted_license":"1","citation":{"mla":"Ellis, Thomas. <i>Pollinator Visitation Data for Wild Antirrhinum Majus Plants, with Phenotypic and Frequency Data.</i> Institute of Science and Technology Austria, 2016, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:36\">10.15479/AT:ISTA:36</a>.","apa":"Ellis, T. (2016). Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic and frequency data. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:36\">https://doi.org/10.15479/AT:ISTA:36</a>","chicago":"Ellis, Thomas. “Pollinator Visitation Data for Wild Antirrhinum Majus Plants, with Phenotypic and Frequency Data.” Institute of Science and Technology Austria, 2016. <a href=\"https://doi.org/10.15479/AT:ISTA:36\">https://doi.org/10.15479/AT:ISTA:36</a>.","ama":"Ellis T. Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic and frequency data. 2016. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:36\">10.15479/AT:ISTA:36</a>","ista":"Ellis T. 2016. Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic and frequency data., Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:36\">10.15479/AT:ISTA:36</a>.","short":"T. Ellis, (2016).","ieee":"T. Ellis, “Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic and frequency data.” Institute of Science and Technology Austria, 2016."},"file":[{"file_name":"IST-2016-36-v1+1_tag_assay_archive.zip","content_type":"application/zip","date_created":"2018-12-12T13:03:07Z","creator":"system","file_id":"5625","file_size":44905,"date_updated":"2020-07-14T12:47:01Z","relation":"main_file","checksum":"cbc61b523d4d475a04a737d50dc470ef","access_level":"open_access"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"1398"}]},"_id":"5552","oa_version":"Published Version","author":[{"first_name":"Thomas","last_name":"Ellis","id":"3153D6D4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8511-0254","full_name":"Ellis, Thomas"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"research_data","month":"02","title":"Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic and frequency data.","date_published":"2016-02-19T00:00:00Z","department":[{"_id":"NiBa"}],"publisher":"Institute of Science and Technology Austria","date_updated":"2026-07-30T14:56:13Z","article_processing_charge":"No","abstract":[{"text":"Data on pollinator visitation to wild snapdragons in a natural hybrid zone, collected as part of Tom Ellis' PhD thesis (submitted February 2016).\r\n\r\nSnapdragon flowers have a mouth-like structure which pollinators must open to access nectar. We placed 5mm cellophane tags in these mouths, which are held in place by the pressure of the flower until a pollinator visits. When she opens the flower, the tag drops out, and one can infer a visit. We surveyed plants over multiple days in 2010, 2011 and 2012.\r\n\r\nAlso included are data on phenotypic and demographic variables which may be explanatory variables for pollinator visitation.","lang":"eng"}],"oa":1,"file_date_updated":"2020-07-14T12:47:01Z"},{"status":"public","day":"14","doi":"10.6084/m9.figshare.4315652.v1","date_created":"2021-08-10T08:29:47Z","year":"2016","main_file_link":[{"open_access":"1","url":"https://doi.org/10.6084/m9.figshare.4315652.v1"}],"citation":{"ama":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. Data from evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. 2016. doi:<a href=\"https://doi.org/10.6084/m9.figshare.4315652.v1\">10.6084/m9.figshare.4315652.v1</a>","ista":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. 2016. Data from evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family, The Royal Society, <a href=\"https://doi.org/10.6084/m9.figshare.4315652.v1\">10.6084/m9.figshare.4315652.v1</a>.","ieee":"R. A. Fernandes Redondo, H. de Vladar, T. Włodarski, and J. P. Bollback, “Data from evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family.” The Royal Society, 2016.","short":"R.A. Fernandes Redondo, H. de Vladar, T. Włodarski, J.P. Bollback, (2016).","mla":"Fernandes Redondo, Rodrigo A., et al. <i>Data from Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family</i>. The Royal Society, 2016, doi:<a href=\"https://doi.org/10.6084/m9.figshare.4315652.v1\">10.6084/m9.figshare.4315652.v1</a>.","apa":"Fernandes Redondo, R. A., de Vladar, H., Włodarski, T., &#38; Bollback, J. P. (2016). Data from evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. The Royal Society. <a href=\"https://doi.org/10.6084/m9.figshare.4315652.v1\">https://doi.org/10.6084/m9.figshare.4315652.v1</a>","chicago":"Fernandes Redondo, Rodrigo A, Harold de Vladar, Tomasz Włodarski, and Jonathan P Bollback. “Data from Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family.” The Royal Society, 2016. <a href=\"https://doi.org/10.6084/m9.figshare.4315652.v1\">https://doi.org/10.6084/m9.figshare.4315652.v1</a>."},"_id":"9864","related_material":{"record":[{"relation":"used_in_publication","id":"1077","status":"public"}]},"type":"research_data_reference","oa_version":"Published Version","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Fernandes Redondo, Rodrigo A","orcid":"0000-0002-5837-2793","id":"409D5C96-F248-11E8-B48F-1D18A9856A87","first_name":"Rodrigo A","last_name":"Fernandes Redondo"},{"last_name":"de Vladar","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5985-7653","full_name":"de Vladar, Harold"},{"last_name":"Włodarski","first_name":"Tomasz","full_name":"Włodarski, Tomasz"},{"full_name":"Bollback, Jonathan P","orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","last_name":"Bollback","first_name":"Jonathan P"}],"date_updated":"2026-08-27T12:09:34Z","department":[{"_id":"NiBa"},{"_id":"JoBo"}],"publisher":"The Royal Society","date_published":"2016-12-14T00:00:00Z","month":"12","title":"Data from evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family","abstract":[{"text":"Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the rates of substitution. To study the evolution of epistasis, we focused on the major structural protein of the ϕX174 phage family by, first, reconstructing the ancestral protein sequences of 18 species using a Bayesian statistical framework. The inferred ancestral reconstruction differed at eight AAs, for a total of 256 possible ancestral haplotypes. For each ancestral haplotype and the extant species, we estimated, in silico, the distribution of free energies and epistasis of the capsid structure. We found that free energy has not significantly increased but epistasis has. We decomposed epistasis up to fifth order and found that higher-order epistasis sometimes compensates pairwise interactions making the free energy seem additive. The dN/dS ratio is low, suggesting strong purifying selection, and that structure is under stabilizing selection. We synthesized phages carrying ancestral haplotypes of the coat protein gene and measured their fitness experimentally. Our findings indicate that stabilizing mutations can have higher fitness, and that fitness optima do not necessarily coincide with energy minima.","lang":"eng"}],"oa":1,"article_processing_charge":"No"},{"isi":1,"oa":1,"date_published":"2015-07-11T00:00:00Z","language":[{"iso":"eng"}],"month":"07","date_updated":"2025-09-23T08:50:33Z","department":[{"_id":"NiBa"},{"_id":"CaGu"}],"publisher":"ACM","arxiv":1,"oa_version":"Preprint","type":"conference","publist_id":"5768","scopus_import":"1","_id":"1430","citation":{"short":"T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp. 1455–1462.","ieee":"T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards a runtime comparison of natural and artificial evolution,” in <i>Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation</i>, Madrid, Spain, 2015, pp. 1455–1462.","ama":"Paixao T, Sudholt D, Heredia J, Trubenova B. First steps towards a runtime comparison of natural and artificial evolution. In: <i>Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation</i>. ACM; 2015:1455-1462. doi:<a href=\"https://doi.org/10.1145/2739480.2754758\">10.1145/2739480.2754758</a>","ista":"Paixao T, Sudholt D, Heredia J, Trubenova B. 2015. First steps towards a runtime comparison of natural and artificial evolution. Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation. GECCO: Genetic and evolutionary computation conference, 1455–1462.","apa":"Paixao, T., Sudholt, D., Heredia, J., &#38; Trubenova, B. (2015). First steps towards a runtime comparison of natural and artificial evolution. In <i>Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation</i> (pp. 1455–1462). Madrid, Spain: ACM. <a href=\"https://doi.org/10.1145/2739480.2754758\">https://doi.org/10.1145/2739480.2754758</a>","chicago":"Paixao, Tiago, Dirk Sudholt, Jorge Heredia, and Barbora Trubenova. “First Steps towards a Runtime Comparison of Natural and Artificial Evolution.” In <i>Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation</i>, 1455–62. ACM, 2015. <a href=\"https://doi.org/10.1145/2739480.2754758\">https://doi.org/10.1145/2739480.2754758</a>.","mla":"Paixao, Tiago, et al. “First Steps towards a Runtime Comparison of Natural and Artificial Evolution.” <i>Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation</i>, ACM, 2015, pp. 1455–62, doi:<a href=\"https://doi.org/10.1145/2739480.2754758\">10.1145/2739480.2754758</a>."},"project":[{"grant_number":"618091","_id":"25B1EC9E-B435-11E9-9278-68D0E5697425","name":"Speed of Adaptation in Population Genetics and Evolutionary Computation","call_identifier":"FP7"}],"ec_funded":1,"day":"11","status":"public","article_processing_charge":"No","page":"1455 - 1462","external_id":{"isi":["000358795700182"],"arxiv":["1504.06260"]},"publication_status":"published","abstract":[{"text":"Evolutionary algorithms (EAs) form a popular optimisation paradigm inspired by natural evolution. In recent years the field of evolutionary computation has developed a rigorous analytical theory to analyse their runtime on many illustrative problems. Here we apply this theory to a simple model of natural evolution. In the Strong Selection Weak Mutation (SSWM) evolutionary regime the time between occurrence of new mutations is much longer than the time it takes for a new beneficial mutation to take over the population. In this situation, the population only contains copies of one genotype and evolution can be modelled as a (1+1)-type process where the probability of accepting a new genotype (improvements or worsenings) depends on the change in fitness. We present an initial runtime analysis of SSWM, quantifying its performance for various parameters and investigating differences to the (1+1) EA. We show that SSWM can have a moderate advantage over the (1+1) EA at crossing fitness valleys and study an example where SSWM outperforms the (1+1) EA by taking advantage of information on the fitness gradient.","lang":"eng"}],"title":"First steps towards a runtime comparison of natural and artificial evolution","author":[{"last_name":"Paixao","first_name":"Tiago","orcid":"0000-0003-2361-3953","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","full_name":"Paixao, Tiago"},{"first_name":"Dirk","last_name":"Sudholt","full_name":"Sudholt, Dirk"},{"last_name":"Heredia","first_name":"Jorge","full_name":"Heredia, Jorge"},{"last_name":"Trubenova","first_name":"Barbora","full_name":"Trubenova, Barbora","orcid":"0000-0002-6873-2967","id":"42302D54-F248-11E8-B48F-1D18A9856A87"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1504.06260"}],"conference":{"name":"GECCO: Genetic and evolutionary computation conference","start_date":"2015-07-11","location":"Madrid, Spain","end_date":"2015-07-15"},"date_created":"2018-12-11T11:51:58Z","year":"2015","doi":"10.1145/2739480.2754758","publication":"Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation"},{"intvolume":"        69","oa_version":"Submitted Version","type":"journal_article","publist_id":"5656","scopus_import":"1","_id":"1519","isi":1,"file_date_updated":"2020-07-14T12:45:00Z","oa":1,"date_published":"2015-03-19T00:00:00Z","language":[{"iso":"eng"}],"month":"03","date_updated":"2025-09-23T13:53:01Z","publisher":"Wiley","department":[{"_id":"NiBa"}],"ec_funded":1,"pubrep_id":"560","status":"public","day":"19","citation":{"ama":"Barton NH, Servedio M. The interpretation of selection coefficients. <i>Evolution</i>. 2015;69(5):1101-1112. doi:<a href=\"https://doi.org/10.1111/evo.12641\">10.1111/evo.12641</a>","ista":"Barton NH, Servedio M. 2015. The interpretation of selection coefficients. Evolution. 69(5), 1101–1112.","ieee":"N. H. Barton and M. Servedio, “The interpretation of selection coefficients,” <i>Evolution</i>, vol. 69, no. 5. Wiley, pp. 1101–1112, 2015.","short":"N.H. Barton, M. Servedio, Evolution 69 (2015) 1101–1112.","mla":"Barton, Nicholas H., and Maria Servedio. “The Interpretation of Selection Coefficients.” <i>Evolution</i>, vol. 69, no. 5, Wiley, 2015, pp. 1101–12, doi:<a href=\"https://doi.org/10.1111/evo.12641\">10.1111/evo.12641</a>.","chicago":"Barton, Nicholas H, and Maria Servedio. “The Interpretation of Selection Coefficients.” <i>Evolution</i>. Wiley, 2015. <a href=\"https://doi.org/10.1111/evo.12641\">https://doi.org/10.1111/evo.12641</a>.","apa":"Barton, N. H., &#38; Servedio, M. (2015). The interpretation of selection coefficients. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.12641\">https://doi.org/10.1111/evo.12641</a>"},"project":[{"call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152"}],"author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton"},{"full_name":"Servedio, Maria","first_name":"Maria","last_name":"Servedio"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":69,"article_processing_charge":"No","page":"1101 - 1112","publication_status":"published","external_id":{"isi":["000354561600001"]},"abstract":[{"lang":"eng","text":"Evolutionary biologists have an array of powerful theoretical techniques that can accurately predict changes in the genetic composition of populations. Changes in gene frequencies and genetic associations between loci can be tracked as they respond to a wide variety of evolutionary forces. However, it is often less clear how to decompose these various forces into components that accurately reflect the underlying biology. Here, we present several issues that arise in the definition and interpretation of selection and selection coefficients, focusing on insights gained through the examination of selection coefficients in multilocus notation. Using this notation, we discuss how its flexibility-which allows different biological units to be identified as targets of selection-is reflected in the interpretation of the coefficients that the notation generates. In many situations, it can be difficult to agree on whether loci can be considered to be under &quot;direct&quot; versus &quot;indirect&quot; selection, or to quantify this selection. We present arguments for what the terms direct and indirect selection might best encompass, considering a range of issues, from viability and sexual selection to kin selection. We show how multilocus notation can discriminate between direct and indirect selection, and describe when it can do so."}],"title":"The interpretation of selection coefficients","date_created":"2018-12-11T11:52:29Z","year":"2015","doi":"10.1111/evo.12641","issue":"5","publication":"Evolution","corr_author":"1","file":[{"date_created":"2018-12-12T10:10:34Z","content_type":"application/pdf","file_name":"IST-2016-560-v1+1_Interpreting_ML_coefficients_11.2.15_App.pdf","creator":"system","file_id":"4822","relation":"main_file","checksum":"fd8d23f476bc194419929b72ca265c02","access_level":"open_access","file_size":188872,"date_updated":"2020-07-14T12:45:00Z"},{"access_level":"open_access","relation":"main_file","checksum":"b774911e70044641d556e258efcb52ef","file_size":577415,"date_updated":"2020-07-14T12:45:00Z","file_id":"4823","creator":"system","date_created":"2018-12-12T10:10:35Z","file_name":"IST-2016-560-v1+2_Interpreting_ML_coefficients_11.2.15_mainText.pdf","content_type":"application/pdf"}],"quality_controlled":"1","has_accepted_license":"1","ddc":["570"]},{"intvolume":"         6","oa_version":"Published Version","article_type":"original","type":"journal_article","publist_id":"5467","scopus_import":"1","_id":"1681","file_date_updated":"2020-07-14T12:45:12Z","oa":1,"date_published":"2015-09-29T00:00:00Z","month":"09","language":[{"iso":"eng"}],"date_updated":"2025-04-15T06:50:21Z","publisher":"MDPI","department":[{"_id":"NiBa"},{"_id":"KrCh"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"pubrep_id":"448","day":"29","status":"public","citation":{"mla":"Priklopil, Tadeas, and Krishnendu Chatterjee. “Evolution of Decisions in Population Games with Sequentially Searching Individuals.” <i>Games</i>, vol. 6, no. 4, MDPI, 2015, pp. 413–37, doi:<a href=\"https://doi.org/10.3390/g6040413\">10.3390/g6040413</a>.","chicago":"Priklopil, Tadeas, and Krishnendu Chatterjee. “Evolution of Decisions in Population Games with Sequentially Searching Individuals.” <i>Games</i>. MDPI, 2015. <a href=\"https://doi.org/10.3390/g6040413\">https://doi.org/10.3390/g6040413</a>.","apa":"Priklopil, T., &#38; Chatterjee, K. (2015). Evolution of decisions in population games with sequentially searching individuals. <i>Games</i>. MDPI. <a href=\"https://doi.org/10.3390/g6040413\">https://doi.org/10.3390/g6040413</a>","ama":"Priklopil T, Chatterjee K. Evolution of decisions in population games with sequentially searching individuals. <i>Games</i>. 2015;6(4):413-437. doi:<a href=\"https://doi.org/10.3390/g6040413\">10.3390/g6040413</a>","ista":"Priklopil T, Chatterjee K. 2015. Evolution of decisions in population games with sequentially searching individuals. Games. 6(4), 413–437.","short":"T. Priklopil, K. Chatterjee, Games 6 (2015) 413–437.","ieee":"T. Priklopil and K. Chatterjee, “Evolution of decisions in population games with sequentially searching individuals,” <i>Games</i>, vol. 6, no. 4. MDPI, pp. 413–437, 2015."},"project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","call_identifier":"FWF"},{"grant_number":"279307","_id":"2581B60A-B435-11E9-9278-68D0E5697425","name":"Quantitative Graph Games: Theory and Applications","call_identifier":"FP7"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Tadeas","last_name":"Priklopil","id":"3C869AA0-F248-11E8-B48F-1D18A9856A87","full_name":"Priklopil, Tadeas"},{"full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee"}],"volume":6,"article_processing_charge":"No","page":"413 - 437","publication_status":"published","abstract":[{"lang":"eng","text":"In many social situations, individuals endeavor to find the single best possible partner, but are constrained to evaluate the candidates in sequence. Examples include the search for mates, economic partnerships, or any other long-term ties where the choice to interact involves two parties. Surprisingly, however, previous theoretical work on mutual choice problems focuses on finding equilibrium solutions, while ignoring the evolutionary dynamics of decisions. Empirically, this may be of high importance, as some equilibrium solutions can never be reached unless the population undergoes radical changes and a sufficient number of individuals change their decisions simultaneously. To address this question, we apply a mutual choice sequential search problem in an evolutionary game-theoretical model that allows one to find solutions that are favored by evolution. As an example, we study the influence of sequential search on the evolutionary dynamics of cooperation. For this, we focus on the classic snowdrift game and the prisoner’s dilemma game."}],"title":"Evolution of decisions in population games with sequentially searching individuals","date_created":"2018-12-11T11:53:26Z","year":"2015","doi":"10.3390/g6040413","publication_identifier":{"eissn":["2073-4336"]},"issue":"4","publication":"Games","corr_author":"1","file":[{"checksum":"912e1acbaf201100f447a43e4d5958bd","relation":"main_file","access_level":"open_access","file_size":518832,"date_updated":"2020-07-14T12:45:12Z","file_id":"4959","creator":"system","date_created":"2018-12-12T10:12:41Z","file_name":"IST-2016-448-v1+1_games-06-00413.pdf","content_type":"application/pdf"}],"quality_controlled":"1","has_accepted_license":"1","ddc":["000"]},{"publication":"Journal of Mathematical Biology","issue":"7","doi":"10.1007/s00285-014-0802-y","year":"2015","date_created":"2018-12-11T11:53:32Z","ddc":["576"],"has_accepted_license":"1","quality_controlled":"1","file":[{"creator":"system","date_created":"2018-12-12T10:14:27Z","file_name":"IST-2016-458-v1+1_s00285-014-0802-y.pdf","content_type":"application/pdf","relation":"main_file","checksum":"00e3a67bda05d4cc165b3a48b41ef9ad","access_level":"open_access","date_updated":"2020-07-14T12:45:12Z","file_size":1321527,"file_id":"5079"}],"corr_author":"1","volume":70,"author":[{"full_name":"Uecker, Hildegard","orcid":"0000-0001-9435-2813","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87","first_name":"Hildegard","last_name":"Uecker"},{"first_name":"Derek","last_name":"Setter","full_name":"Setter, Derek"},{"full_name":"Hermisson, Joachim","last_name":"Hermisson","first_name":"Joachim"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Adaptive gene introgression after secondary contact","abstract":[{"lang":"eng","text":"By hybridization and backcrossing, alleles can surmount species boundaries and be incorporated into the genome of a related species. This introgression of genes is of particular evolutionary relevance if it involves the transfer of adaptations between populations. However, any beneficial allele will typically be associated with other alien alleles that are often deleterious and hamper the introgression process. In order to describe the introgression of an adaptive allele, we set up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious alleles. Based on the theory of reducible multitype branching processes, we derive a recursive expression for the establishment probability of the beneficial allele after a single hybridization event. We furthermore study the probability that slightly deleterious alleles hitchhike to fixation. The key to the analysis is a split of the process into a stochastic phase in which the advantageous alleles establishes and a deterministic phase in which it sweeps to fixation. We thereafter apply the theory to a set of biologically relevant scenarios such as introgression in the presence of many unlinked or few closely linked deleterious alleles. A comparison to computer simulations shows that the approximations work well over a large parameter range."}],"publication_status":"published","external_id":{"isi":["000354196800003"]},"page":"1523 - 1580","article_processing_charge":"No","day":"01","pubrep_id":"458","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"project":[{"name":"Evolutionary rescue","_id":"25B67606-B435-11E9-9278-68D0E5697425"}],"citation":{"short":"H. Uecker, D. Setter, J. Hermisson, Journal of Mathematical Biology 70 (2015) 1523–1580.","ieee":"H. Uecker, D. Setter, and J. Hermisson, “Adaptive gene introgression after secondary contact,” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7. Springer, pp. 1523–1580, 2015.","ista":"Uecker H, Setter D, Hermisson J. 2015. Adaptive gene introgression after secondary contact. Journal of Mathematical Biology. 70(7), 1523–1580.","ama":"Uecker H, Setter D, Hermisson J. Adaptive gene introgression after secondary contact. <i>Journal of Mathematical Biology</i>. 2015;70(7):1523-1580. doi:<a href=\"https://doi.org/10.1007/s00285-014-0802-y\">10.1007/s00285-014-0802-y</a>","apa":"Uecker, H., Setter, D., &#38; Hermisson, J. (2015). Adaptive gene introgression after secondary contact. <i>Journal of Mathematical Biology</i>. Springer. <a href=\"https://doi.org/10.1007/s00285-014-0802-y\">https://doi.org/10.1007/s00285-014-0802-y</a>","chicago":"Uecker, Hildegard, Derek Setter, and Joachim Hermisson. “Adaptive Gene Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>. Springer, 2015. <a href=\"https://doi.org/10.1007/s00285-014-0802-y\">https://doi.org/10.1007/s00285-014-0802-y</a>.","mla":"Uecker, Hildegard, et al. “Adaptive Gene Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7, Springer, 2015, pp. 1523–80, doi:<a href=\"https://doi.org/10.1007/s00285-014-0802-y\">10.1007/s00285-014-0802-y</a>."},"_id":"1699","scopus_import":"1","publist_id":"5442","acknowledgement":"This work was made possible with financial support by the Vienna Science and Technology Fund (WWTF), by the Deutsche Forschungsgemeinschaft (DFG), Research Unit 1078 Natural selection in structured populations, by the Austrian Science Fund (FWF) via funding for the Vienna Graduate School for Population Genetics, and by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with the Austrian Commission for UNESCO and the Austrian Academy of Sciences with financial support from the Federal Ministry for Science and Research Austria).","type":"journal_article","oa_version":"Published Version","intvolume":"        70","publisher":"Springer","department":[{"_id":"NiBa"}],"date_updated":"2025-09-23T07:31:45Z","month":"06","language":[{"iso":"eng"}],"date_published":"2015-06-01T00:00:00Z","oa":1,"file_date_updated":"2020-07-14T12:45:12Z","isi":1},{"day":"26","status":"public","citation":{"chicago":"Broadhurst, Linda, Graham Fifield, Bindi Vanzella, and Melinda Pickup. “An Evaluation of the Genetic Structure of Seed Sources and the Maintenance of Genetic Diversity during Establishment of Two Yellow Box (Eucalyptus Melliodora) Seed-Production Areas.” <i>Australian Journal of Botany</i>. CSIRO, 2015. <a href=\"https://doi.org/10.1071/BT15023\">https://doi.org/10.1071/BT15023</a>.","apa":"Broadhurst, L., Fifield, G., Vanzella, B., &#38; Pickup, M. (2015). An evaluation of the genetic structure of seed sources and the maintenance of genetic diversity during establishment of two yellow box (Eucalyptus melliodora) seed-production areas. <i>Australian Journal of Botany</i>. CSIRO. <a href=\"https://doi.org/10.1071/BT15023\">https://doi.org/10.1071/BT15023</a>","mla":"Broadhurst, Linda, et al. “An Evaluation of the Genetic Structure of Seed Sources and the Maintenance of Genetic Diversity during Establishment of Two Yellow Box (Eucalyptus Melliodora) Seed-Production Areas.” <i>Australian Journal of Botany</i>, vol. 63, no. 5, CSIRO, 2015, pp. 455–66, doi:<a href=\"https://doi.org/10.1071/BT15023\">10.1071/BT15023</a>.","short":"L. Broadhurst, G. Fifield, B. Vanzella, M. Pickup, Australian Journal of Botany 63 (2015) 455–466.","ieee":"L. Broadhurst, G. Fifield, B. Vanzella, and M. Pickup, “An evaluation of the genetic structure of seed sources and the maintenance of genetic diversity during establishment of two yellow box (Eucalyptus melliodora) seed-production areas,” <i>Australian Journal of Botany</i>, vol. 63, no. 5. CSIRO, pp. 455–466, 2015.","ista":"Broadhurst L, Fifield G, Vanzella B, Pickup M. 2015. An evaluation of the genetic structure of seed sources and the maintenance of genetic diversity during establishment of two yellow box (Eucalyptus melliodora) seed-production areas. Australian Journal of Botany. 63(5), 455–466.","ama":"Broadhurst L, Fifield G, Vanzella B, Pickup M. An evaluation of the genetic structure of seed sources and the maintenance of genetic diversity during establishment of two yellow box (Eucalyptus melliodora) seed-production areas. <i>Australian Journal of Botany</i>. 2015;63(5):455-466. doi:<a href=\"https://doi.org/10.1071/BT15023\">10.1071/BT15023</a>"},"type":"journal_article","intvolume":"        63","oa_version":"None","scopus_import":"1","_id":"1703","publist_id":"5434","isi":1,"date_updated":"2025-09-23T07:51:07Z","department":[{"_id":"NiBa"}],"publisher":"CSIRO","date_published":"2015-05-26T00:00:00Z","month":"05","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:53:34Z","year":"2015","publication":"Australian Journal of Botany","doi":"10.1071/BT15023","issue":"5","quality_controlled":"1","volume":63,"author":[{"full_name":"Broadhurst, Linda","first_name":"Linda","last_name":"Broadhurst"},{"full_name":"Fifield, Graham","first_name":"Graham","last_name":"Fifield"},{"last_name":"Vanzella","first_name":"Bindi","full_name":"Vanzella, Bindi"},{"first_name":"Melinda","last_name":"Pickup","full_name":"Pickup, Melinda","orcid":"0000-0001-6118-0541","id":"2C78037E-F248-11E8-B48F-1D18A9856A87"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","external_id":{"isi":["000363276500009"]},"abstract":[{"lang":"eng","text":"Vegetation clearing and land-use change have depleted many natural plant communities to the point where restoration is required. A major impediment to the success of rebuilding complex vegetation communities is having regular access to sufficient quantities of high-quality seed. Seed-production areas (SPAs) can help generate this seed, but these must be underpinned by a broad genetic base to maximise the evolutionary potential of restored populations. However, genetic bottlenecks can occur at the collection, establishment and production stages in SPAs, requiring genetic evaluation. This is especially relevant for species that may take many years before a return on SPA investment is realised. Two recently established yellow box (Eucalyptus melliodora A.Cunn. ex Schauer, Myrtaceae) SPAs were evaluated to determine whether genetic bottlenecks had occurred between seed collection and SPA establishment. No evidence was found to suggest that a significant loss of genetic diversity had occurred at this stage, although there was a significant difference in diversity between the two SPAs. Complex population genetic structure was also observed in the seed used to source the SPAs, with up to eight groups identified. Plant survival in the SPAs was influenced by seed collection location but not by SPA location and was not associated with genetic diversity. There were also no associations between genetic diversity and plant growth. These data highlighted the importance of chance events when establishing SPAs and indicated that the two yellow box SPAs are likely to provide genetically diverse seed sources for future restoration projects, especially by pooling seed from both SPAs."}],"article_processing_charge":"No","page":"455 - 466","title":"An evaluation of the genetic structure of seed sources and the maintenance of genetic diversity during establishment of two yellow box (Eucalyptus melliodora) seed-production areas"},{"doi":"10.1016/j.jtbi.2015.02.018","issue":"5","publication":"Journal of Theoretical Biology","date_created":"2018-12-11T11:54:21Z","year":"2015","has_accepted_license":"1","ddc":["576"],"corr_author":"1","quality_controlled":"1","file":[{"file_id":"5326","relation":"main_file","checksum":"3c0dcacc900bc45cc65a453dfda4ca43","access_level":"open_access","date_updated":"2020-07-14T12:45:19Z","file_size":1546914,"date_created":"2018-12-12T10:18:07Z","content_type":"application/pdf","file_name":"IST-2015-329-v1+1_manuscript.pdf","creator":"system"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"full_name":"Novak, Sebastian","id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X","last_name":"Novak","first_name":"Sebastian"},{"first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"volume":372,"title":"Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates","article_processing_charge":"No","page":"54 - 64","publication_status":"published","external_id":{"isi":["000353311700006"]},"abstract":[{"text":"Entomopathogenic fungi are potent biocontrol agents that are widely used against insect pests, many of which are social insects. Nevertheless, theoretical investigations of their particular life history are scarce. We develop a model that takes into account the main distinguishing features between traditionally studied diseases and obligate killing pathogens, like the (biocontrol-relevant) insect-pathogenic fungi Metarhizium and Beauveria. First, obligate killing entomopathogenic fungi produce new infectious particles (conidiospores) only after host death and not yet on the living host. Second, the killing rates of entomopathogenic fungi depend strongly on the initial exposure dosage, thus we explicitly consider the pathogen load of individual hosts. Further, we make the model applicable not only to solitary host species, but also to group living species by incorporating social interactions between hosts, like the collective disease defences of insect societies. Our results identify the optimal killing rate for the pathogen that minimises its invasion threshold. Furthermore, we find that the rate of contact between hosts has an ambivalent effect: dense interaction networks between individuals are considered to facilitate disease outbreaks because of increased pathogen transmission. In social insects, this is compensated by their collective disease defences, i.e., social immunity. For the type of pathogens considered here, we show that even without social immunity, high contact rates between live individuals dilute the pathogen in the host colony and hence can reduce individual pathogen loads below disease-causing levels.","lang":"eng"}],"day":"07","status":"public","pubrep_id":"329","ec_funded":1,"citation":{"apa":"Novak, S., &#38; Cremer, S. (2015). Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. <i>Journal of Theoretical Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jtbi.2015.02.018\">https://doi.org/10.1016/j.jtbi.2015.02.018</a>","chicago":"Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect Societies: Optimal Killing Rates and the Ambivalent Effect of High Social Interaction Rates.” <i>Journal of Theoretical Biology</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.jtbi.2015.02.018\">https://doi.org/10.1016/j.jtbi.2015.02.018</a>.","mla":"Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect Societies: Optimal Killing Rates and the Ambivalent Effect of High Social Interaction Rates.” <i>Journal of Theoretical Biology</i>, vol. 372, no. 5, Elsevier, 2015, pp. 54–64, doi:<a href=\"https://doi.org/10.1016/j.jtbi.2015.02.018\">10.1016/j.jtbi.2015.02.018</a>.","short":"S. Novak, S. Cremer, Journal of Theoretical Biology 372 (2015) 54–64.","ieee":"S. Novak and S. Cremer, “Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates,” <i>Journal of Theoretical Biology</i>, vol. 372, no. 5. Elsevier, pp. 54–64, 2015.","ista":"Novak S, Cremer S. 2015. Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. Journal of Theoretical Biology. 372(5), 54–64.","ama":"Novak S, Cremer S. Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. <i>Journal of Theoretical Biology</i>. 2015;372(5):54-64. doi:<a href=\"https://doi.org/10.1016/j.jtbi.2015.02.018\">10.1016/j.jtbi.2015.02.018</a>"},"project":[{"grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7"},{"name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects","call_identifier":"FP7","grant_number":"243071","_id":"25DC711C-B435-11E9-9278-68D0E5697425"}],"publist_id":"5251","scopus_import":"1","_id":"1850","intvolume":"       372","oa_version":"Submitted Version","type":"journal_article","date_published":"2015-05-07T00:00:00Z","month":"05","language":[{"iso":"eng"}],"date_updated":"2025-09-23T08:54:35Z","publisher":"Elsevier","department":[{"_id":"NiBa"},{"_id":"SyCr"}],"isi":1,"file_date_updated":"2020-07-14T12:45:19Z","oa":1},{"abstract":[{"lang":"eng","text":"We consider mating strategies for females who search for males sequentially during a season of limited length. We show that the best strategy rejects a given male type if encountered before a time-threshold but accepts him after. For frequency-independent benefits, we obtain the optimal time-thresholds explicitly for both discrete and continuous distributions of males, and allow for mistakes being made in assessing the correct male type. When the benefits are indirect (genes for the offspring) and the population is under frequency-dependent ecological selection, the benefits depend on the mating strategy of other females as well. This case is particularly relevant to speciation models that seek to explore the stability of reproductive isolation by assortative mating under frequency-dependent ecological selection. We show that the indirect benefits are to be quantified by the reproductive values of couples, and describe how the evolutionarily stable time-thresholds can be found. We conclude with an example based on the Levene model, in which we analyze the evolutionarily stable assortative mating strategies and the strength of reproductive isolation provided by them."}],"external_id":{"isi":["000353236000014"],"pmid":["25662095"]},"publication_status":"published","page":"1015 - 1026","article_processing_charge":"No","title":"Evolutionarily stable mating decisions for sequentially searching females and the stability of reproductive isolation by assortative mating","volume":69,"author":[{"last_name":"Priklopil","first_name":"Tadeas","id":"3C869AA0-F248-11E8-B48F-1D18A9856A87","full_name":"Priklopil, Tadeas"},{"full_name":"Kisdi, Eva","last_name":"Kisdi","first_name":"Eva"},{"full_name":"Gyllenberg, Mats","last_name":"Gyllenberg","first_name":"Mats"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","pmid":1,"quality_controlled":"1","file":[{"date_created":"2020-05-15T09:05:34Z","file_name":"2015_Evolution_Priklopil.pdf","content_type":"application/pdf","creator":"dernst","file_id":"7855","access_level":"open_access","relation":"main_file","checksum":"1e8be0b1d7598a78cd2623d8ee8e7798","date_updated":"2020-07-14T12:45:19Z","file_size":967214}],"corr_author":"1","ddc":["570"],"has_accepted_license":"1","year":"2015","date_created":"2018-12-11T11:54:21Z","publication":"Evolution","issue":"4","publication_identifier":{"issn":["0014-3820"],"eissn":["1558-5646"]},"doi":"10.1111/evo.12618","oa":1,"file_date_updated":"2020-07-14T12:45:19Z","isi":1,"publisher":"Wiley","department":[{"_id":"NiBa"},{"_id":"KrCh"}],"date_updated":"2025-09-22T14:27:30Z","month":"02","language":[{"iso":"eng"}],"date_published":"2015-02-09T00:00:00Z","type":"journal_article","article_type":"original","oa_version":"Submitted Version","intvolume":"        69","_id":"1851","scopus_import":"1","publist_id":"5249","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"citation":{"ista":"Priklopil T, Kisdi E, Gyllenberg M. 2015. Evolutionarily stable mating decisions for sequentially searching females and the stability of reproductive isolation by assortative mating. Evolution. 69(4), 1015–1026.","ama":"Priklopil T, Kisdi E, Gyllenberg M. Evolutionarily stable mating decisions for sequentially searching females and the stability of reproductive isolation by assortative mating. <i>Evolution</i>. 2015;69(4):1015-1026. doi:<a href=\"https://doi.org/10.1111/evo.12618\">10.1111/evo.12618</a>","ieee":"T. Priklopil, E. Kisdi, and M. Gyllenberg, “Evolutionarily stable mating decisions for sequentially searching females and the stability of reproductive isolation by assortative mating,” <i>Evolution</i>, vol. 69, no. 4. Wiley, pp. 1015–1026, 2015.","short":"T. Priklopil, E. Kisdi, M. Gyllenberg, Evolution 69 (2015) 1015–1026.","mla":"Priklopil, Tadeas, et al. “Evolutionarily Stable Mating Decisions for Sequentially Searching Females and the Stability of Reproductive Isolation by Assortative Mating.” <i>Evolution</i>, vol. 69, no. 4, Wiley, 2015, pp. 1015–26, doi:<a href=\"https://doi.org/10.1111/evo.12618\">10.1111/evo.12618</a>.","apa":"Priklopil, T., Kisdi, E., &#38; Gyllenberg, M. (2015). Evolutionarily stable mating decisions for sequentially searching females and the stability of reproductive isolation by assortative mating. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.12618\">https://doi.org/10.1111/evo.12618</a>","chicago":"Priklopil, Tadeas, Eva Kisdi, and Mats Gyllenberg. “Evolutionarily Stable Mating Decisions for Sequentially Searching Females and the Stability of Reproductive Isolation by Assortative Mating.” <i>Evolution</i>. Wiley, 2015. <a href=\"https://doi.org/10.1111/evo.12618\">https://doi.org/10.1111/evo.12618</a>."},"ec_funded":1,"status":"public","day":"09"},{"year":"2015","date_created":"2021-07-23T12:00:37Z","doi":"10.1371/journal.pgen.1005639.s001","day":"06","status":"public","citation":{"chicago":"Tugrul, Murat, Tiago Paixao, Nicholas H Barton, and Gašper Tkačik. “Other Fitness Models for Comparison &#38; for Interacting TFBSs.” Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pgen.1005639.s001\">https://doi.org/10.1371/journal.pgen.1005639.s001</a>.","apa":"Tugrul, M., Paixao, T., Barton, N. H., &#38; Tkačik, G. (2015). Other fitness models for comparison &#38; for interacting TFBSs. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1005639.s001\">https://doi.org/10.1371/journal.pgen.1005639.s001</a>","mla":"Tugrul, Murat, et al. <i>Other Fitness Models for Comparison &#38; for Interacting TFBSs</i>. Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1005639.s001\">10.1371/journal.pgen.1005639.s001</a>.","ieee":"M. Tugrul, T. Paixao, N. H. Barton, and G. Tkačik, “Other fitness models for comparison &#38; for interacting TFBSs.” Public Library of Science, 2015.","short":"M. Tugrul, T. Paixao, N.H. Barton, G. Tkačik, (2015).","ista":"Tugrul M, Paixao T, Barton NH, Tkačik G. 2015. Other fitness models for comparison &#38; for interacting TFBSs, Public Library of Science, <a href=\"https://doi.org/10.1371/journal.pgen.1005639.s001\">10.1371/journal.pgen.1005639.s001</a>.","ama":"Tugrul M, Paixao T, Barton NH, Tkačik G. Other fitness models for comparison &#38; for interacting TFBSs. 2015. doi:<a href=\"https://doi.org/10.1371/journal.pgen.1005639.s001\">10.1371/journal.pgen.1005639.s001</a>"},"author":[{"last_name":"Tugrul","first_name":"Murat","id":"37C323C6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8523-0758","full_name":"Tugrul, Murat"},{"orcid":"0000-0003-2361-3953","id":"2C5658E6-F248-11E8-B48F-1D18A9856A87","full_name":"Paixao, Tiago","first_name":"Tiago","last_name":"Paixao"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H"},{"orcid":"0000-0002-6699-1455","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkačik, Gašper","last_name":"Tkačik","first_name":"Gašper"}],"oa_version":"Published Version","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","related_material":{"record":[{"status":"public","id":"1666","relation":"used_in_publication"}]},"_id":"9712","article_processing_charge":"No","title":"Other fitness models for comparison & for interacting TFBSs","month":"11","date_published":"2015-11-06T00:00:00Z","department":[{"_id":"NiBa"},{"_id":"CaGu"},{"_id":"GaTk"}],"publisher":"Public Library of Science","date_updated":"2025-09-23T08:31:14Z"},{"citation":{"ista":"Trubenova B, Novak S, Hager R. 2015. Mathematical inference of the results, Public Library of Science, <a href=\"https://doi.org/10.1371/journal.pone.0126907.s001\">10.1371/journal.pone.0126907.s001</a>.","ama":"Trubenova B, Novak S, Hager R. Mathematical inference of the results. 2015. doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907.s001\">10.1371/journal.pone.0126907.s001</a>","ieee":"B. Trubenova, S. Novak, and R. Hager, “Mathematical inference of the results.” Public Library of Science, 2015.","short":"B. Trubenova, S. Novak, R. Hager, (2015).","mla":"Trubenova, Barbora, et al. <i>Mathematical Inference of the Results</i>. Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907.s001\">10.1371/journal.pone.0126907.s001</a>.","chicago":"Trubenova, Barbora, Sebastian Novak, and Reinmar Hager. “Mathematical Inference of the Results.” Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pone.0126907.s001\">https://doi.org/10.1371/journal.pone.0126907.s001</a>.","apa":"Trubenova, B., Novak, S., &#38; Hager, R. (2015). Mathematical inference of the results. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0126907.s001\">https://doi.org/10.1371/journal.pone.0126907.s001</a>"},"doi":"10.1371/journal.pone.0126907.s001","day":"18","status":"public","date_created":"2021-07-23T12:11:30Z","year":"2015","date_published":"2015-05-18T00:00:00Z","title":"Mathematical inference of the results","month":"05","date_updated":"2025-09-23T09:21:54Z","publisher":"Public Library of Science","department":[{"_id":"NiBa"}],"article_processing_charge":"No","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"1809"}]},"_id":"9715","oa_version":"Published Version","author":[{"last_name":"Trubenova","first_name":"Barbora","id":"42302D54-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6873-2967","full_name":"Trubenova, Barbora"},{"id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X","full_name":"Novak, Sebastian","last_name":"Novak","first_name":"Sebastian"},{"full_name":"Hager, Reinmar","first_name":"Reinmar","last_name":"Hager"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference"},{"citation":{"ista":"Trubenova B, Novak S, Hager R. 2015. Description of the agent based simulations, Public Library of Science, <a href=\"https://doi.org/10.1371/journal.pone.0126907.s003\">10.1371/journal.pone.0126907.s003</a>.","ama":"Trubenova B, Novak S, Hager R. Description of the agent based simulations. 2015. doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907.s003\">10.1371/journal.pone.0126907.s003</a>","ieee":"B. Trubenova, S. Novak, and R. Hager, “Description of the agent based simulations.” Public Library of Science, 2015.","short":"B. Trubenova, S. Novak, R. Hager, (2015).","mla":"Trubenova, Barbora, et al. <i>Description of the Agent Based Simulations</i>. Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907.s003\">10.1371/journal.pone.0126907.s003</a>.","chicago":"Trubenova, Barbora, Sebastian Novak, and Reinmar Hager. “Description of the Agent Based Simulations.” Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pone.0126907.s003\">https://doi.org/10.1371/journal.pone.0126907.s003</a>.","apa":"Trubenova, B., Novak, S., &#38; Hager, R. (2015). Description of the agent based simulations. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0126907.s003\">https://doi.org/10.1371/journal.pone.0126907.s003</a>"},"year":"2015","date_created":"2021-08-05T12:55:20Z","status":"public","day":"18","doi":"10.1371/journal.pone.0126907.s003","article_processing_charge":"No","publisher":"Public Library of Science","department":[{"_id":"NiBa"}],"date_updated":"2025-09-23T09:21:54Z","month":"05","title":"Description of the agent based simulations","date_published":"2015-05-18T00:00:00Z","type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","oa_version":"Published Version","author":[{"full_name":"Trubenova, Barbora","id":"42302D54-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6873-2967","last_name":"Trubenova","first_name":"Barbora"},{"full_name":"Novak, Sebastian","id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X","first_name":"Sebastian","last_name":"Novak"},{"first_name":"Reinmar","last_name":"Hager","full_name":"Hager, Reinmar"}],"related_material":{"record":[{"id":"1809","relation":"used_in_publication","status":"public"}]},"_id":"9772"},{"related_material":{"record":[{"status":"public","id":"9715","relation":"research_data"},{"status":"public","relation":"research_data","id":"9772"}]},"volume":10,"author":[{"full_name":"Trubenova, Barbora","id":"42302D54-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6873-2967","last_name":"Trubenova","first_name":"Barbora"},{"full_name":"Novak, Sebastian","id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X","last_name":"Novak","first_name":"Sebastian"},{"first_name":"Reinmar","last_name":"Hager","full_name":"Hager, Reinmar"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Indirect genetic effects and the dynamics of social interactions","abstract":[{"text":"Background: Indirect genetic effects (IGEs) occur when genes expressed in one individual alter the expression of traits in social partners. Previous studies focused on the evolutionary consequences and evolutionary dynamics of IGEs, using equilibrium solutions to predict phenotypes in subsequent generations. However, whether or not such steady states may be reached may depend on the dynamics of interactions themselves. Results: In our study, we focus on the dynamics of social interactions and indirect genetic effects and investigate how they modify phenotypes over time. Unlike previous IGE studies, we do not analyse evolutionary dynamics; rather we consider within-individual phenotypic changes, also referred to as phenotypic plasticity. We analyse iterative interactions, when individuals interact in a series of discontinuous events, and investigate the stability of steady state solutions and the dependence on model parameters, such as population size, strength, and the nature of interactions. We show that for interactions where a feedback loop occurs, the possible parameter space of interaction strength is fairly limited, affecting the evolutionary consequences of IGEs. We discuss the implications of our results for current IGE model predictions and their limitations.","lang":"eng"}],"publication_status":"published","external_id":{"isi":["000354917300064"]},"article_processing_charge":"No","publication":"PLoS One","issue":"5","doi":"10.1371/journal.pone.0126907","year":"2015","date_created":"2018-12-11T11:54:07Z","ddc":["570","576"],"has_accepted_license":"1","file":[{"creator":"system","content_type":"application/pdf","file_name":"IST-2016-453-v1+1_journal.pone.0126907.pdf","date_created":"2018-12-12T10:09:07Z","file_size":2748982,"date_updated":"2020-07-14T12:45:17Z","relation":"main_file","checksum":"d3a4a58ef4bd3b3e2f32b7fd7af4a743","access_level":"open_access","file_id":"4730"}],"quality_controlled":"1","corr_author":"1","_id":"1809","scopus_import":"1","publist_id":"5299","type":"journal_article","intvolume":"        10","oa_version":"Published Version","publisher":"Public Library of Science","department":[{"_id":"NiBa"}],"date_updated":"2025-09-23T09:21:54Z","month":"05","language":[{"iso":"eng"}],"date_published":"2015-05-18T00:00:00Z","oa":1,"file_date_updated":"2020-07-14T12:45:17Z","isi":1,"day":"18","pubrep_id":"453","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"citation":{"mla":"Trubenova, Barbora, et al. “Indirect Genetic Effects and the Dynamics of Social Interactions.” <i>PLoS One</i>, vol. 10, no. 5, Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907\">10.1371/journal.pone.0126907</a>.","chicago":"Trubenova, Barbora, Sebastian Novak, and Reinmar Hager. “Indirect Genetic Effects and the Dynamics of Social Interactions.” <i>PLoS One</i>. Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pone.0126907\">https://doi.org/10.1371/journal.pone.0126907</a>.","apa":"Trubenova, B., Novak, S., &#38; Hager, R. (2015). Indirect genetic effects and the dynamics of social interactions. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0126907\">https://doi.org/10.1371/journal.pone.0126907</a>","ista":"Trubenova B, Novak S, Hager R. 2015. Indirect genetic effects and the dynamics of social interactions. PLoS One. 10(5).","ama":"Trubenova B, Novak S, Hager R. Indirect genetic effects and the dynamics of social interactions. <i>PLoS One</i>. 2015;10(5). doi:<a href=\"https://doi.org/10.1371/journal.pone.0126907\">10.1371/journal.pone.0126907</a>","ieee":"B. Trubenova, S. Novak, and R. Hager, “Indirect genetic effects and the dynamics of social interactions,” <i>PLoS One</i>, vol. 10, no. 5. Public Library of Science, 2015.","short":"B. Trubenova, S. Novak, R. Hager, PLoS One 10 (2015)."}},{"citation":{"ista":"Polechova J, Barton NH. 2015. Limits to adaptation along environmental gradients. PNAS. 112(20), 6401–6406.","ama":"Polechova J, Barton NH. Limits to adaptation along environmental gradients. <i>PNAS</i>. 2015;112(20):6401-6406. doi:<a href=\"https://doi.org/10.1073/pnas.1421515112\">10.1073/pnas.1421515112</a>","ieee":"J. Polechova and N. H. Barton, “Limits to adaptation along environmental gradients,” <i>PNAS</i>, vol. 112, no. 20. National Academy of Sciences, pp. 6401–6406, 2015.","short":"J. Polechova, N.H. Barton, PNAS 112 (2015) 6401–6406.","mla":"Polechova, Jitka, and Nicholas H. Barton. “Limits to Adaptation along Environmental Gradients.” <i>PNAS</i>, vol. 112, no. 20, National Academy of Sciences, 2015, pp. 6401–06, doi:<a href=\"https://doi.org/10.1073/pnas.1421515112\">10.1073/pnas.1421515112</a>.","chicago":"Polechova, Jitka, and Nicholas H Barton. “Limits to Adaptation along Environmental Gradients.” <i>PNAS</i>. National Academy of Sciences, 2015. <a href=\"https://doi.org/10.1073/pnas.1421515112\">https://doi.org/10.1073/pnas.1421515112</a>.","apa":"Polechova, J., &#38; Barton, N. H. (2015). Limits to adaptation along environmental gradients. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1421515112\">https://doi.org/10.1073/pnas.1421515112</a>"},"project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation"}],"ec_funded":1,"day":"19","status":"public","isi":1,"oa":1,"date_published":"2015-05-19T00:00:00Z","language":[{"iso":"eng"}],"month":"05","date_updated":"2025-09-23T09:27:16Z","publisher":"National Academy of Sciences","department":[{"_id":"NiBa"}],"intvolume":"       112","oa_version":"Submitted Version","type":"journal_article","publist_id":"5288","scopus_import":"1","_id":"1818","corr_author":"1","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443383/"}],"date_created":"2018-12-11T11:54:11Z","year":"2015","doi":"10.1073/pnas.1421515112","issue":"20","publication":"PNAS","article_processing_charge":"No","page":"6401 - 6406","publication_status":"published","external_id":{"pmid":["25941385"],"isi":["000354729500058"]},"abstract":[{"text":"Why do species not adapt to ever-wider ranges of conditions, gradually expanding their ecological niche and geographic range? Gene flow across environments has two conflicting effects: although it increases genetic variation, which is a prerequisite for adaptation, gene flow may swamp adaptation to local conditions. In 1956, Haldane proposed that, when the environment varies across space, &quot;swamping&quot; by gene flow creates a positive feedback between low population size and maladaptation, leading to a sharp range margin. However, current deterministic theory shows that, when variance can evolve, there is no such limit. Using simple analytical tools and simulations, we show that genetic drift can generate a sharp margin to a species' range, by reducing genetic variance below the level needed for adaptation to spatially variable conditions. Aided by separation of ecological and evolutionary timescales, the identified effective dimensionless parameters reveal a simple threshold that predicts when adaptation at the range margin fails. Two observable parameters determine the threshold: (i) the effective environmental gradient, which can be measured by the loss of fitness due to dispersal to a different environment; and (ii) the efficacy of selection relative to genetic drift. The theory predicts sharp range margins even in the absence of abrupt changes in the environment. Furthermore, it implies that gradual worsening of conditions across a species' habitat may lead to a sudden range fragmentation, when adaptation to a wide span of conditions within a single species becomes impossible.","lang":"eng"}],"title":"Limits to adaptation along environmental gradients","author":[{"full_name":"Polechova, Jitka","orcid":"0000-0003-0951-3112","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","first_name":"Jitka","last_name":"Polechova"},{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":112,"pmid":1}]