[{"publication_identifier":{"isbn":["9780691149776"]},"quality_controlled":"1","corr_author":"1","citation":{"ista":"Barton NH. 2013.Recombination and sex. In: The Princeton Guide to Evolution. , 328–333.","ama":"Barton NH. Recombination and sex. In: <i>The Princeton Guide to Evolution</i>. Princeton University Press; 2013:328-333.","mla":"Barton, Nicholas H. “Recombination and Sex.” <i>The Princeton Guide to Evolution</i>, Princeton University Press, 2013, pp. 328–33.","short":"N.H. Barton, in:, The Princeton Guide to Evolution, Princeton University Press, 2013, pp. 328–333.","ieee":"N. H. Barton, “Recombination and sex,” in <i>The Princeton Guide to Evolution</i>, Princeton University Press, 2013, pp. 328–333.","apa":"Barton, N. H. (2013). Recombination and sex. In <i>The Princeton Guide to Evolution</i> (pp. 328–333). Princeton University Press.","chicago":"Barton, Nicholas H. “Recombination and Sex.” In <i>The Princeton Guide to Evolution</i>, 328–33. Princeton University Press, 2013."},"has_accepted_license":"1","department":[{"_id":"NiBa"}],"date_created":"2018-12-11T12:00:16Z","publication":"The Princeton Guide to Evolution","oa":1,"year":"2013","month":"11","oa_version":"Submitted Version","publication_status":"published","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton"}],"ddc":["576"],"pubrep_id":"119","publisher":"Princeton University Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"book_chapter","status":"public","_id":"2907","date_updated":"2024-10-09T20:55:04Z","page":"328 - 333","title":"Recombination and sex","file_date_updated":"2020-07-14T12:45:52Z","abstract":[{"lang":"eng","text":"Sex and recombination are among the most striking features of the living world, and they play a crucial role in allowing the evolution of complex adaptation. The sharing of genomes through the sexual union of different individuals requires elaborate behavioral and physiological adaptations. At the molecular level, the alignment of two DNA double helices, followed by their precise cutting and rejoining, is an extraordinary feat. Sex and recombination have diverse—and often surprising—evolutionary consequences: distinct sexes, elaborate mating displays, selfish genetic elements, and so on."}],"file":[{"creator":"system","relation":"main_file","date_created":"2018-12-12T10:16:47Z","date_updated":"2020-07-14T12:45:52Z","checksum":"8332ca9cb40f7e66d1006b175ce36b60","file_size":79838,"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_name":"IST-2013-119-v1+1_IV.4_Recombination_and_Sex_Barton_1-13-13-e.docx","file_id":"5237","access_level":"open_access"},{"file_name":"IST-2017-119-v1+2_Barton_Recombination_Sex.pdf","content_type":"application/pdf","access_level":"open_access","file_id":"5238","date_created":"2018-12-12T10:16:48Z","relation":"main_file","creator":"system","file_size":144131,"checksum":"849f418620fb78d6ba23bb4f488ee93f","date_updated":"2020-07-14T12:45:52Z"}],"publist_id":"3839","language":[{"iso":"eng"}],"day":"04","date_published":"2013-11-04T00:00:00Z"},{"quality_controlled":"1","volume":26,"has_accepted_license":"1","corr_author":"1","citation":{"ama":"Barton NH. Does hybridisation influence speciation?  . <i>Journal of Evolutionary Biology</i>. 2013;26(2):267-269. doi:<a href=\"https://doi.org/10.1111/jeb.12015\">10.1111/jeb.12015</a>","mla":"Barton, Nicholas H. “Does Hybridisation Influence Speciation?  .” <i>Journal of Evolutionary Biology</i>, vol. 26, no. 2, Wiley-Blackwell, 2013, pp. 267–69, doi:<a href=\"https://doi.org/10.1111/jeb.12015\">10.1111/jeb.12015</a>.","ista":"Barton NH. 2013. Does hybridisation influence speciation?  . Journal of Evolutionary Biology. 26(2), 267–269.","chicago":"Barton, Nicholas H. “Does Hybridisation Influence Speciation?  .” <i>Journal of Evolutionary Biology</i>. Wiley-Blackwell, 2013. <a href=\"https://doi.org/10.1111/jeb.12015\">https://doi.org/10.1111/jeb.12015</a>.","ieee":"N. H. Barton, “Does hybridisation influence speciation?  ,” <i>Journal of Evolutionary Biology</i>, vol. 26, no. 2. Wiley-Blackwell, pp. 267–269, 2013.","apa":"Barton, N. H. (2013). Does hybridisation influence speciation?  . <i>Journal of Evolutionary Biology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/jeb.12015\">https://doi.org/10.1111/jeb.12015</a>","short":"N.H. Barton, Journal of Evolutionary Biology 26 (2013) 267–269."},"publication":"Journal of Evolutionary Biology","scopus_import":"1","department":[{"_id":"NiBa"}],"date_created":"2018-12-11T12:00:17Z","article_processing_charge":"No","oa":1,"year":"2013","intvolume":"        26","issue":"2","oa_version":"Submitted Version","month":"01","publication_status":"published","author":[{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H"}],"pubrep_id":"111","ddc":["576"],"doi":"10.1111/jeb.12015","publisher":"Wiley-Blackwell","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","type":"journal_article","_id":"2908","status":"public","page":"267 - 269","date_updated":"2025-09-29T13:31:43Z","file_date_updated":"2020-07-14T12:45:52Z","abstract":[{"lang":"eng","text":"Hybridization is an almost inevitable component of speciation, and its study can tell us much about that process. However, hybridization itself may have a negligible influence on the origin of species: on the one hand, universally favoured alleles spread readily across hybrid zones, whilst on the other, spatially heterogeneous selection causes divergence despite gene flow. Thus, narrow hybrid zones or occasional hybridisation may hardly affect the process of divergence."}],"title":"Does hybridisation influence speciation?  ","isi":1,"fulldoi":"https://doi.org/10.1111/jeb.12015","publist_id":"3835","file":[{"file_id":"4762","access_level":"open_access","file_name":"IST-2013-111-v1+1_Hybridisation_and_speciation_revised.rtf","content_type":"text/rtf","date_updated":"2020-07-14T12:45:52Z","checksum":"716e88714c3411cd0bd70928b14ea692","file_size":13339,"creator":"system","relation":"main_file","date_created":"2018-12-12T10:09:38Z"},{"relation":"main_file","date_created":"2018-12-12T10:09:39Z","creator":"system","file_size":103437,"date_updated":"2020-07-14T12:45:52Z","checksum":"957fd07c71c1b1eac2c65ae3311aca78","file_name":"IST-2017-111-v1+2_Hybridisation_and_speciation_revised.pdf","content_type":"application/pdf","access_level":"open_access","file_id":"4763"}],"language":[{"iso":"eng"}],"external_id":{"isi":["000313747600007"]},"day":"17","date_published":"2013-01-17T00:00:00Z"},{"external_id":{"isi":["000315410500003"]},"publist_id":"3834","fulldoi":"https://doi.org/10.1088/1742-5468/2013/01/P01002","isi":1,"file":[{"date_created":"2018-12-12T10:16:52Z","relation":"main_file","creator":"system","file_size":702583,"date_updated":"2020-07-14T12:45:52Z","checksum":"ce8a4424385b3086138a1e054e16e0e3","file_name":"IST-2016-557-v1+1_BEVrevised.pdf","content_type":"application/pdf","access_level":"open_access","file_id":"5242"}],"language":[{"iso":"eng"}],"date_published":"2013-01-16T00:00:00Z","day":"16","publisher":"IOP Publishing","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1088/1742-5468/2013/01/P01002","type":"journal_article","project":[{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"status":"public","_id":"2909","date_updated":"2025-09-29T13:31:08Z","title":"Modelling evolution in a spatial continuum","file_date_updated":"2020-07-14T12:45:52Z","abstract":[{"text":"We survey a class of models for spatially structured populations\r\nwhich we have called spatial Λ-Fleming–Viot processes. They arise from a flexible\r\nframework for modelling in which the key innovation is that random genetic drift\r\nis driven by a Poisson point process of spatial ‘events’. We demonstrate how this\r\novercomes some of the obstructions to modelling populations which evolve in two-\r\n(and higher-) dimensional spatial continua, how its predictions match phenomena\r\nobserved in data and how it fits with classical models. Finally we outline some\r\ndirections for future research.","lang":"eng"}],"article_processing_charge":"No","year":"2013","oa":1,"month":"01","issue":"1","intvolume":"      2013","oa_version":"Submitted Version","publication_status":"published","author":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"},{"last_name":"Etheridge","first_name":"Alison","full_name":"Etheridge, Alison"},{"last_name":"Véber","first_name":"Amandine","full_name":"Véber, Amandine"}],"ddc":["570"],"pubrep_id":"557","volume":2013,"ec_funded":1,"quality_controlled":"1","corr_author":"1","citation":{"short":"N.H. Barton, A. Etheridge, A. Véber, Journal of Statistical Mechanics Theory and Experiment 2013 (2013).","ieee":"N. H. Barton, A. Etheridge, and A. Véber, “Modelling evolution in a spatial continuum,” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 1. IOP Publishing, 2013.","apa":"Barton, N. H., Etheridge, A., &#38; Véber, A. (2013). Modelling evolution in a spatial continuum. <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1742-5468/2013/01/P01002\">https://doi.org/10.1088/1742-5468/2013/01/P01002</a>","chicago":"Barton, Nicholas H, Alison Etheridge, and Amandine Véber. “Modelling Evolution in a Spatial Continuum.” <i>Journal of Statistical Mechanics Theory and Experiment</i>. IOP Publishing, 2013. <a href=\"https://doi.org/10.1088/1742-5468/2013/01/P01002\">https://doi.org/10.1088/1742-5468/2013/01/P01002</a>.","ista":"Barton NH, Etheridge A, Véber A. 2013. Modelling evolution in a spatial continuum. Journal of Statistical Mechanics Theory and Experiment. 2013(1).","ama":"Barton NH, Etheridge A, Véber A. Modelling evolution in a spatial continuum. <i>Journal of Statistical Mechanics Theory and Experiment</i>. 2013;2013(1). doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/01/P01002\">10.1088/1742-5468/2013/01/P01002</a>","mla":"Barton, Nicholas H., et al. “Modelling Evolution in a Spatial Continuum.” <i>Journal of Statistical Mechanics Theory and Experiment</i>, vol. 2013, no. 1, IOP Publishing, 2013, doi:<a href=\"https://doi.org/10.1088/1742-5468/2013/01/P01002\">10.1088/1742-5468/2013/01/P01002</a>."},"has_accepted_license":"1","department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2018-12-11T12:00:17Z","publication":"Journal of Statistical Mechanics Theory and Experiment"},{"title":"Coalescent simulation in continuous space","file_date_updated":"2020-07-14T12:45:52Z","abstract":[{"text":"Coalescent simulation has become an indispensable tool in population genetics and many complex evolutionary scenarios have been incorporated into the basic algorithm. Despite many years of intense interest in spatial structure, however, there are no available methods to simulate the ancestry of a sample of genes that occupy a spatial continuum. This is mainly due to the severe technical problems encountered by the classical model of isolation\r\nby distance. A recently introduced model solves these technical problems and provides a solid theoretical basis for the study of populations evolving in continuous space. We present a detailed algorithm to simulate the coalescent process in this model, and provide an efficient implementation of a generalised version of this algorithm as a freely available Python module.","lang":"eng"}],"page":"955 - 956","date_updated":"2025-09-29T13:30:36Z","type":"journal_article","project":[{"call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152"}],"status":"public","_id":"2910","publisher":"Oxford University Press","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1093/bioinformatics/btt067","date_published":"2013-02-07T00:00:00Z","day":"07","external_id":{"isi":["000316695700020"]},"publist_id":"3833","fulldoi":"https://doi.org/10.1093/bioinformatics/btt067","isi":1,"file":[{"file_size":170197,"checksum":"a3b54d7477fac923815ac082403d9bd0","date_updated":"2020-07-14T12:45:52Z","date_created":"2018-12-12T10:16:04Z","relation":"main_file","creator":"system","access_level":"open_access","file_id":"5189","file_name":"IST-2016-556-v1+1_bioinformatics-2013.pdf","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"scopus_import":"1","department":[{"_id":"NiBa"}],"date_created":"2018-12-11T12:00:17Z","publication":"Bioinformatics","corr_author":"1","citation":{"chicago":"Kelleher, Jerome, Nicholas H Barton, and Alison Etheridge. “Coalescent Simulation in Continuous Space.” <i>Bioinformatics</i>. Oxford University Press, 2013. <a href=\"https://doi.org/10.1093/bioinformatics/btt067\">https://doi.org/10.1093/bioinformatics/btt067</a>.","short":"J. Kelleher, N.H. Barton, A. Etheridge, Bioinformatics 29 (2013) 955–956.","apa":"Kelleher, J., Barton, N. H., &#38; Etheridge, A. (2013). Coalescent simulation in continuous space. <i>Bioinformatics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/bioinformatics/btt067\">https://doi.org/10.1093/bioinformatics/btt067</a>","ieee":"J. Kelleher, N. H. Barton, and A. Etheridge, “Coalescent simulation in continuous space,” <i>Bioinformatics</i>, vol. 29, no. 7. Oxford University Press, pp. 955–956, 2013.","ama":"Kelleher J, Barton NH, Etheridge A. Coalescent simulation in continuous space. <i>Bioinformatics</i>. 2013;29(7):955-956. doi:<a href=\"https://doi.org/10.1093/bioinformatics/btt067\">10.1093/bioinformatics/btt067</a>","mla":"Kelleher, Jerome, et al. “Coalescent Simulation in Continuous Space.” <i>Bioinformatics</i>, vol. 29, no. 7, Oxford University Press, 2013, pp. 955–56, doi:<a href=\"https://doi.org/10.1093/bioinformatics/btt067\">10.1093/bioinformatics/btt067</a>.","ista":"Kelleher J, Barton NH, Etheridge A. 2013. Coalescent simulation in continuous space. Bioinformatics. 29(7), 955–956."},"has_accepted_license":"1","volume":29,"ec_funded":1,"quality_controlled":"1","ddc":["570"],"pubrep_id":"556","publication_status":"published","author":[{"last_name":"Kelleher","first_name":"Jerome","full_name":"Kelleher, Jerome"},{"last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Etheridge","first_name":"Alison","full_name":"Etheridge, Alison"}],"month":"02","issue":"7","oa_version":"Published Version","intvolume":"        29","article_processing_charge":"No","year":"2013","oa":1},{"author":[{"first_name":"Simon","full_name":"Aeschbacher, Simon","id":"2D35326E-F248-11E8-B48F-1D18A9856A87","last_name":"Aeschbacher"},{"full_name":"Futschik, Andreas","first_name":"Andreas","last_name":"Futschik"},{"full_name":"Beaumont, Mark","first_name":"Mark","last_name":"Beaumont"}],"publication_status":"published","month":"02","intvolume":"        22","oa_version":"None","issue":"4","year":"2013","article_processing_charge":"No","date_created":"2018-12-11T12:00:28Z","scopus_import":"1","department":[{"_id":"NiBa"}],"publication":"Molecular Ecology","citation":{"ista":"Aeschbacher S, Futschik A, Beaumont M. 2013. Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. . Molecular Ecology. 22(4), 987–1002.","mla":"Aeschbacher, Simon, et al. “Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates. .” <i>Molecular Ecology</i>, vol. 22, no. 4, Wiley-Blackwell, 2013, pp. 987–1002, doi:<a href=\"https://doi.org/10.1111/mec.12165\">10.1111/mec.12165</a>.","ama":"Aeschbacher S, Futschik A, Beaumont M. Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. . <i>Molecular Ecology</i>. 2013;22(4):987-1002. doi:<a href=\"https://doi.org/10.1111/mec.12165\">10.1111/mec.12165</a>","short":"S. Aeschbacher, A. Futschik, M. Beaumont, Molecular Ecology 22 (2013) 987–1002.","apa":"Aeschbacher, S., Futschik, A., &#38; Beaumont, M. (2013). Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. . <i>Molecular Ecology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/mec.12165\">https://doi.org/10.1111/mec.12165</a>","ieee":"S. Aeschbacher, A. Futschik, and M. Beaumont, “Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. ,” <i>Molecular Ecology</i>, vol. 22, no. 4. Wiley-Blackwell, pp. 987–1002, 2013.","chicago":"Aeschbacher, Simon, Andreas Futschik, and Mark Beaumont. “Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates. .” <i>Molecular Ecology</i>. Wiley-Blackwell, 2013. <a href=\"https://doi.org/10.1111/mec.12165\">https://doi.org/10.1111/mec.12165</a>."},"corr_author":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"related_material":{"record":[{"id":"9758","relation":"research_data","status":"public"}]},"volume":22,"quality_controlled":"1","acknowledgement":"This study has made use of the computational resources provided by IST Austria and the Edinburgh Compute and Data Facility (ECDF; http://www.ecdf.ed.ac.uk). The ECDF is partially supported by the eDIKT initiative (http://www.edikt.org.uk). S.A. acknowledges financial support by IST Austria, the Janggen-Pöhn Foundation, St. Gallen, the Roche Research Foundation, Basel, the University of Edinburgh in the form of a Torrance Studentship, and the Austrian Science Fund (FWF P21305-N13).","date_published":"2013-02-01T00:00:00Z","day":"01","external_id":{"isi":["000314220900008"]},"language":[{"iso":"eng"}],"isi":1,"fulldoi":"https://doi.org/10.1111/mec.12165","publist_id":"3788","title":"Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. ","abstract":[{"text":"We propose a two-step procedure for estimating multiple migration rates in an approximate Bayesian computation (ABC) framework, accounting for global nuisance parameters. The approach is not limited to migration, but generally of interest for inference problems with multiple parameters and a modular structure (e.g. independent sets of demes or loci). We condition on a known, but complex demographic model of a spatially subdivided population, motivated by the reintroduction of Alpine ibex (Capra ibex) into Switzerland. In the first step, the global parameters ancestral mutation rate and male mating skew have been estimated for the whole population in Aeschbacher et al. (Genetics 2012; 192: 1027). In the second step, we estimate in this study the migration rates independently for clusters of demes putatively connected by migration. For large clusters (many migration rates), ABC faces the problem of too many summary statistics. We therefore assess by simulation if estimation per pair of demes is a valid alternative. We find that the trade-off between reduced dimensionality for the pairwise estimation on the one hand and lower accuracy due to the assumption of pairwise independence on the other depends on the number of migration rates to be inferred: the accuracy of the pairwise approach increases with the number of parameters, relative to the joint estimation approach. To distinguish between low and zero migration, we perform ABC-type model comparison between a model with migration and one without. Applying the approach to microsatellite data from Alpine ibex, we find no evidence for substantial gene flow via migration, except for one pair of demes in one direction.","lang":"eng"}],"page":"987 - 1002","date_updated":"2025-09-29T13:25:36Z","_id":"2944","status":"public","type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Wiley-Blackwell","doi":"10.1111/mec.12165"},{"fulldoi":"https://doi.org/10.5061/dryad.r3r60","author":[{"last_name":"Hearn","full_name":"Hearn, Jack","first_name":"Jack"},{"full_name":"Stone, Graham","first_name":"Graham","last_name":"Stone"},{"last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Lohse","first_name":"Konrad","full_name":"Lohse, Konrad"},{"last_name":"Bunnefeld","first_name":"Lynsey","full_name":"Bunnefeld, Lynsey"}],"date_published":"2013-10-01T00:00:00Z","day":"01","article_processing_charge":"No","oa":1,"year":"2013","oa_version":"Published Version","main_file_link":[{"url":"https://doi.org/10.5061/dryad.r3r60","open_access":"1"}],"month":"10","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"2170"}]},"date_updated":"2025-09-29T11:38:51Z","citation":{"apa":"Hearn, J., Stone, G., Barton, N. H., Lohse, K., &#38; Bunnefeld, L. (2013). Data from: Likelihood-based inference of population history from low coverage de novo genome assemblies. Dryad. <a href=\"https://doi.org/10.5061/dryad.r3r60\">https://doi.org/10.5061/dryad.r3r60</a>","ieee":"J. Hearn, G. Stone, N. H. Barton, K. Lohse, and L. Bunnefeld, “Data from: Likelihood-based inference of population history from low coverage de novo genome assemblies.” Dryad, 2013.","short":"J. Hearn, G. Stone, N.H. Barton, K. Lohse, L. Bunnefeld, (2013).","chicago":"Hearn, Jack, Graham Stone, Nicholas H Barton, Konrad Lohse, and Lynsey Bunnefeld. “Data from: Likelihood-Based Inference of Population History from Low Coverage de Novo Genome Assemblies.” Dryad, 2013. <a href=\"https://doi.org/10.5061/dryad.r3r60\">https://doi.org/10.5061/dryad.r3r60</a>.","ista":"Hearn J, Stone G, Barton NH, Lohse K, Bunnefeld L. 2013. Data from: Likelihood-based inference of population history from low coverage de novo genome assemblies, Dryad, <a href=\"https://doi.org/10.5061/dryad.r3r60\">10.5061/dryad.r3r60</a>.","ama":"Hearn J, Stone G, Barton NH, Lohse K, Bunnefeld L. Data from: Likelihood-based inference of population history from low coverage de novo genome assemblies. 2013. doi:<a href=\"https://doi.org/10.5061/dryad.r3r60\">10.5061/dryad.r3r60</a>","mla":"Hearn, Jack, et al. <i>Data from: Likelihood-Based Inference of Population History from Low Coverage de Novo Genome Assemblies</i>. Dryad, 2013, doi:<a href=\"https://doi.org/10.5061/dryad.r3r60\">10.5061/dryad.r3r60</a>."},"abstract":[{"text":"Short-read sequencing technologies have in principle made it feasible to draw detailed inferences about the recent history of any organism. In practice, however, this remains challenging due to the difficulty of genome assembly in most organisms and the lack of statistical methods powerful enough to discriminate among recent, non-equilibrium histories. We address both the assembly and inference challenges. We develop a bioinformatic pipeline for generating outgroup-rooted alignments of orthologous sequence blocks from de novo low-coverage short-read data for a small number of genomes, and show how such sequence blocks can be used to fit explicit models of population divergence and admixture in a likelihood framework. To illustrate our approach, we reconstruct the Pleistocene history of an oak-feeding insect (the oak gallwasp Biorhiza pallida) which, in common with many other taxa, was restricted during Pleistocene ice ages to a longitudinal series of southern refugia spanning theWestern Palaearctic. Our analysis of sequence blocks sampled from a single genome from each of three major glacial refugia reveals support for an unexpected history dominated by recent admixture. Despite the fact that 80% of the genome is affected by admixture during the last glacial cycle, we are able to infer the deeper divergence history of these populations. These inferences are robust to variation in block length, mutation model, and the sampling location of individual genomes within refugia. This combination of de novo assembly and numerical likelihood calculation provides a powerful framework for estimating recent population history that can be applied to any organism without the need for prior genetic resources.","lang":"eng"}],"department":[{"_id":"NiBa"}],"title":"Data from: Likelihood-based inference of population history from low coverage de novo genome assemblies","date_created":"2021-07-30T08:31:22Z","doi":"10.5061/dryad.r3r60","publisher":"Dryad","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","_id":"9754","status":"public"},{"title":"Source population characteristics affect heterosis following genetic rescue of fragmented plant populations","abstract":[{"lang":"eng","text":"Understanding the relative importance of heterosis and outbreeding depression over multiple generations is a key question in evolutionary biology and is essential for identifying appropriate genetic sources for population and ecosystem restoration. Here we use 2455 experimental crosses between 12 population pairs of the rare perennial plant Rutidosis leptorrhynchoides (Asteraceae) to investigate the multi-generational (F1, F2, F3) fitness outcomes of inter-population hybridization. We detected no evidence of outbreeding depression, with inter-population hybrids and backcrosses showing either similar fitness or significant heterosis for fitness components across the three generations. Variation in heterosis among population pairs was best explained by characteristics of the foreign source or home population, and was greatest when the source population was large, with high genetic diversity and low inbreeding, and the home population was small and inbred. Our results indicate that the primary consideration for maximizing progeny fitness following population augmentation or restoration is the use of seed from large, genetically diverse populations."}],"pmid":1,"date_updated":"2026-08-12T06:25:53Z","type":"journal_article","status":"public","_id":"450","publisher":"Royal Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1098/rspb.2012.2058","day":"07","date_published":"2013-01-07T00:00:00Z","external_id":{"pmid":["23173202"],"isi":["000311943100012"]},"fulldoi":"https://doi.org/10.1098/rspb.2012.2058","publist_id":"7372","isi":1,"language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"date_created":"2018-12-11T11:46:32Z","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","corr_author":"1","citation":{"mla":"Pickup, Melinda, et al. “Source Population Characteristics Affect Heterosis Following Genetic Rescue of Fragmented Plant Populations.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 280, no. 1750, 2058, Royal Society, 2013, doi:<a href=\"https://doi.org/10.1098/rspb.2012.2058\">10.1098/rspb.2012.2058</a>.","ama":"Pickup M, Field D, Rowell D, Young A. Source population characteristics affect heterosis following genetic rescue of fragmented plant populations. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2013;280(1750). doi:<a href=\"https://doi.org/10.1098/rspb.2012.2058\">10.1098/rspb.2012.2058</a>","ista":"Pickup M, Field D, Rowell D, Young A. 2013. Source population characteristics affect heterosis following genetic rescue of fragmented plant populations. Proceedings of the Royal Society of London Series B Biological Sciences. 280(1750), 2058.","chicago":"Pickup, Melinda, David Field, David Rowell, and Andrew Young. “Source Population Characteristics Affect Heterosis Following Genetic Rescue of Fragmented Plant Populations.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, 2013. <a href=\"https://doi.org/10.1098/rspb.2012.2058\">https://doi.org/10.1098/rspb.2012.2058</a>.","short":"M. Pickup, D. Field, D. Rowell, A. Young, Proceedings of the Royal Society of London Series B Biological Sciences 280 (2013).","apa":"Pickup, M., Field, D., Rowell, D., &#38; Young, A. (2013). Source population characteristics affect heterosis following genetic rescue of fragmented plant populations. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society. <a href=\"https://doi.org/10.1098/rspb.2012.2058\">https://doi.org/10.1098/rspb.2012.2058</a>","ieee":"M. Pickup, D. Field, D. Rowell, and A. Young, “Source population characteristics affect heterosis following genetic rescue of fragmented plant populations,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 280, no. 1750. Royal Society, 2013."},"volume":280,"quality_controlled":"1","article_number":"2058","publication_status":"published","author":[{"id":"2C78037E-F248-11E8-B48F-1D18A9856A87","first_name":"Melinda","full_name":"Pickup, Melinda","orcid":"0000-0001-6118-0541","last_name":"Pickup"},{"last_name":"Field","first_name":"David","full_name":"Field, David","orcid":"0000-0002-4014-8478","id":"419049E2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Rowell, David","first_name":"David","last_name":"Rowell"},{"first_name":"Andrew","full_name":"Young, Andrew","last_name":"Young"}],"month":"01","intvolume":"       280","oa_version":"Submitted Version","issue":"1750","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574427/"}],"article_processing_charge":"No","oa":1,"year":"2013"},{"author":[{"id":"2A181218-F248-11E8-B48F-1D18A9856A87","first_name":"Harold","full_name":"Vladar, Harold","orcid":"0000-0002-5985-7653","last_name":"Vladar"}],"publication_status":"published","oa_version":"None","issue":"1","intvolume":"        12","month":"11","year":"2012","article_processing_charge":"No","publication":"International Journal of Astrobiology","date_created":"2018-12-11T12:00:19Z","scopus_import":"1","department":[{"_id":"NiBa"}],"citation":{"short":"H. de Vladar, International Journal of Astrobiology 12 (2012) 53–62.","ieee":"H. de Vladar, “The game of active search for extra terrestrial intelligence Breaking the Great Silence ,” <i>International Journal of Astrobiology</i>, vol. 12, no. 1. Cambridge University Press, pp. 53–62, 2012.","apa":"de Vladar, H. (2012). The game of active search for extra terrestrial intelligence Breaking the Great Silence . <i>International Journal of Astrobiology</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S1473550412000407\">https://doi.org/10.1017/S1473550412000407</a>","chicago":"Vladar, Harold de. “The Game of Active Search for Extra Terrestrial Intelligence Breaking the Great Silence .” <i>International Journal of Astrobiology</i>. Cambridge University Press, 2012. <a href=\"https://doi.org/10.1017/S1473550412000407\">https://doi.org/10.1017/S1473550412000407</a>.","ista":"de Vladar H. 2012. The game of active search for extra terrestrial intelligence Breaking the Great Silence . International Journal of Astrobiology. 12(1), 53–62.","mla":"de Vladar, Harold. “The Game of Active Search for Extra Terrestrial Intelligence Breaking the Great Silence .” <i>International Journal of Astrobiology</i>, vol. 12, no. 1, Cambridge University Press, 2012, pp. 53–62, doi:<a href=\"https://doi.org/10.1017/S1473550412000407\">10.1017/S1473550412000407</a>.","ama":"de Vladar H. The game of active search for extra terrestrial intelligence Breaking the Great Silence . <i>International Journal of Astrobiology</i>. 2012;12(1):53-62. doi:<a href=\"https://doi.org/10.1017/S1473550412000407\">10.1017/S1473550412000407</a>"},"corr_author":"1","quality_controlled":"1","volume":12,"date_published":"2012-11-06T00:00:00Z","day":"06","language":[{"iso":"eng"}],"isi":1,"fulldoi":"https://doi.org/10.1017/S1473550412000407","publist_id":"3821","external_id":{"isi":["000312526700008"]},"abstract":[{"text":"The search for extra-terrestrial intelligence (SETI) has been performed principally as a one-way survey, listening of radio frequencies across the Milky Way and other galaxies. However, scientists have engaged in an active messaging only rarely. This suggests the simple rationale that if other civilizations exist and take a similar approach to ours, namely listening but not broadcasting, the result is a silent universe. A simple game theoretical model, the prisoner's dilemma, explains this situation: each player (civilization) can passively search (defect), or actively search and broadcast (cooperate). In order to maximize the payoff (or, equivalently, minimize the risks) the best strategy is not to broadcast. In fact, the active search has been opposed on the basis that it might be dangerous to expose ourselves. However, most of these ideas have not been based on objective arguments, and ignore accounting of the possible gains and losses. Thus, the question stands: should we perform an active search? I develop a game-theoretical framework where civilizations can be of different types, and explicitly apply it to a situation where societies are either interested in establishing a two-way communication or belligerent and in urge to exploit ours. The framework gives a quantitative solution (a mixed-strategy), which is how frequent we should perform the active SETI. This frequency is roughly proportional to the inverse of the risk, and can be extremely small. However, given the immense amount of stars being scanned, it supports active SETI. The model is compared with simulations, and the possible actions are evaluated through the San Marino scale, measuring the risks of messaging.","lang":"eng"}],"title":"The game of active search for extra terrestrial intelligence Breaking the Great Silence ","page":"53 - 62","date_updated":"2025-09-29T13:28:52Z","_id":"2917","status":"public","type":"journal_article","doi":"10.1017/S1473550412000407","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Cambridge University Press"},{"scopus_import":"1","department":[{"_id":"NiBa"}],"date_created":"2018-12-11T12:00:34Z","publication":"Genetics","corr_author":"1","citation":{"chicago":"Aeschbacher, Simon, Mark Beaumont, and Andreas Futschik. “A Novel Approach for Choosing Summary Statistics in Approximate Bayesian Computation.” <i>Genetics</i>. Genetics Society of America, 2012. <a href=\"https://doi.org/10.1534/genetics.112.143164\">https://doi.org/10.1534/genetics.112.143164</a>.","apa":"Aeschbacher, S., Beaumont, M., &#38; Futschik, A. (2012). A novel approach for choosing summary statistics in approximate Bayesian computation. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.112.143164\">https://doi.org/10.1534/genetics.112.143164</a>","ieee":"S. Aeschbacher, M. Beaumont, and A. Futschik, “A novel approach for choosing summary statistics in approximate Bayesian computation,” <i>Genetics</i>, vol. 192, no. 3. Genetics Society of America, pp. 1027–1047, 2012.","short":"S. Aeschbacher, M. Beaumont, A. Futschik, Genetics 192 (2012) 1027–1047.","mla":"Aeschbacher, Simon, et al. “A Novel Approach for Choosing Summary Statistics in Approximate Bayesian Computation.” <i>Genetics</i>, vol. 192, no. 3, Genetics Society of America, 2012, pp. 1027–47, doi:<a href=\"https://doi.org/10.1534/genetics.112.143164\">10.1534/genetics.112.143164</a>.","ama":"Aeschbacher S, Beaumont M, Futschik A. A novel approach for choosing summary statistics in approximate Bayesian computation. <i>Genetics</i>. 2012;192(3):1027-1047. doi:<a href=\"https://doi.org/10.1534/genetics.112.143164\">10.1534/genetics.112.143164</a>","ista":"Aeschbacher S, Beaumont M, Futschik A. 2012. A novel approach for choosing summary statistics in approximate Bayesian computation. Genetics. 192(3), 1027–1047."},"acknowledged_ssus":[{"_id":"ScienComp"}],"volume":192,"quality_controlled":"1","publication_status":"published","author":[{"first_name":"Simon","full_name":"Aeschbacher, Simon","id":"2D35326E-F248-11E8-B48F-1D18A9856A87","last_name":"Aeschbacher"},{"full_name":"Beaumont, Mark","first_name":"Mark","last_name":"Beaumont"},{"full_name":"Futschik, Andreas","first_name":"Andreas","last_name":"Futschik"}],"month":"11","issue":"3","oa_version":"Submitted Version","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522150/"}],"intvolume":"       192","article_processing_charge":"No","oa":1,"year":"2012","title":"A novel approach for choosing summary statistics in approximate Bayesian computation","abstract":[{"text":"The choice of summary statistics is a crucial step in approximate Bayesian computation (ABC). Since statistics are often not sufficient, this choice involves a trade-off between loss of information and reduction of dimensionality. The latter may increase the efficiency of ABC. Here, we propose an approach for choosing summary statistics based on boosting, a technique from the machine learning literature. We consider different types of boosting and compare them to partial least squares regression as an alternative. To mitigate the lack of sufficiency, we also propose an approach for choosing summary statistics locally, in the putative neighborhood of the true parameter value. We study a demographic model motivated by the re-introduction of Alpine ibex (Capra ibex) into the Swiss Alps. The parameters of interest are the mean and standard deviation across microsatellites of the scaled ancestral mutation rate (θanc = 4 Ne u), and the proportion of males obtaining access to matings per breeding season (ω). By simulation, we assess the properties of the posterior distribution obtained with the various methods. According to our criteria, ABC with summary statistics chosen locally via boosting with the L2-loss performs best. Applying that method to the ibex data, we estimate θanc ≈ 1.288, and find that most of the variation across loci of the ancestral mutation rate u is between 7.7×10−4 and 3.5×10−3 per locus per generation. The proportion of males with access to matings is estimated to ω ≈ 0.21, which is in good agreement with recent independent estimates.","lang":"eng"}],"pmid":1,"date_updated":"2025-09-30T08:06:06Z","page":"1027 - 1047","type":"journal_article","status":"public","_id":"2962","publisher":"Genetics Society of America","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1534/genetics.112.143164","day":"01","date_published":"2012-11-01T00:00:00Z","external_id":{"isi":["000310793900018"],"pmid":["22960215"]},"fulldoi":"https://doi.org/10.1534/genetics.112.143164","isi":1,"publist_id":"3763","language":[{"iso":"eng"}]},{"article_processing_charge":"No","oa":1,"year":"2012","oa_version":"Submitted Version","issue":"18","intvolume":"        21","month":"09","publication_status":"published","author":[{"last_name":"Lohse","first_name":"Konrad","full_name":"Lohse, Konrad"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton"},{"last_name":"Melika","full_name":"Melika, George","first_name":"George"},{"last_name":"Stone","full_name":"Stone, Graham","first_name":"Graham"}],"pubrep_id":"296","ddc":["570","579"],"acknowledgement":"This work was supported by funding from the UK Natural Environment Research Council to KL (NE/I020288/1) and GS (NE/H000038/1, NE/E014453/1, NER/B/504406/1, NER/B/S2003/00856) and a grant from the European Research Council (250152) to NB.\r\nWe thank Majide Tavakoli, Juli Pujade-Villar and Pablo-Fuentes Utrilla for contributing specimens. Mike Hickerson and three anonymous reviewers gave helpful comments on earlier versions of the manuscript. ","quality_controlled":"1","ec_funded":1,"volume":21,"related_material":{"record":[{"id":"13075","relation":"research_data","status":"public"}]},"has_accepted_license":"1","citation":{"apa":"Lohse, K., Barton, N. H., Melika, G., &#38; Stone, G. (2012). A likelihood based comparison of population histories in a parasitoid guild. <i>Molecular Ecology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05700.x\">https://doi.org/10.1111/j.1365-294X.2012.05700.x</a>","ieee":"K. Lohse, N. H. Barton, G. Melika, and G. Stone, “A likelihood based comparison of population histories in a parasitoid guild,” <i>Molecular Ecology</i>, vol. 21, no. 18. Wiley-Blackwell, pp. 4605–4617, 2012.","short":"K. Lohse, N.H. Barton, G. Melika, G. Stone, Molecular Ecology 21 (2012) 4605–4617.","chicago":"Lohse, Konrad, Nicholas H Barton, George Melika, and Graham Stone. “A Likelihood Based Comparison of Population Histories in a Parasitoid Guild.” <i>Molecular Ecology</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05700.x\">https://doi.org/10.1111/j.1365-294X.2012.05700.x</a>.","ista":"Lohse K, Barton NH, Melika G, Stone G. 2012. A likelihood based comparison of population histories in a parasitoid guild. Molecular Ecology. 21(18), 4605–4617.","mla":"Lohse, Konrad, et al. “A Likelihood Based Comparison of Population Histories in a Parasitoid Guild.” <i>Molecular Ecology</i>, vol. 21, no. 18, Wiley-Blackwell, 2012, pp. 4605–17, doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05700.x\">10.1111/j.1365-294X.2012.05700.x</a>.","ama":"Lohse K, Barton NH, Melika G, Stone G. A likelihood based comparison of population histories in a parasitoid guild. <i>Molecular Ecology</i>. 2012;21(18):4605-4617. doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05700.x\">10.1111/j.1365-294X.2012.05700.x</a>"},"publication":"Molecular Ecology","department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2018-12-11T12:00:36Z","fulldoi":"https://doi.org/10.1111/j.1365-294X.2012.05700.x","file":[{"creator":"system","relation":"main_file","date_created":"2018-12-12T10:17:47Z","date_updated":"2020-07-14T12:45:57Z","checksum":"c14ee4cb2a8ba9575bfd8a9bb7a883bb","file_size":235820,"file_name":"IST-2014-296-v1+1_4_wasps_revised3.pdf","content_type":"application/pdf","file_id":"5304","access_level":"open_access"},{"access_level":"open_access","file_id":"5305","file_name":"IST-2014-296-v1+2_4_wasps_Supporting2.pdf","content_type":"application/pdf","file_size":41975,"date_updated":"2020-07-14T12:45:57Z","checksum":"f00afc5b887c8222014b57375b8caece","relation":"main_file","date_created":"2018-12-12T10:17:48Z","creator":"system"}],"publist_id":"3746","isi":1,"language":[{"iso":"eng"}],"external_id":{"isi":["000308634300016"]},"date_published":"2012-09-01T00:00:00Z","day":"01","doi":"10.1111/j.1365-294X.2012.05700.x","publisher":"Wiley-Blackwell","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","project":[{"grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"type":"journal_article","_id":"2968","status":"public","date_updated":"2025-09-30T08:04:03Z","page":"4605 - 4617","file_date_updated":"2020-07-14T12:45:57Z","abstract":[{"text":"Little is known about the stability of trophic relationships in complex natural communities over evolutionary timescales. Here, we use sequence data from 18 nuclear loci to reconstruct and compare the intraspecific histories of major Pleistocene refugial populations in the Middle East, the Balkans and Iberia in a guild of four Chalcid parasitoids (Cecidostiba fungosa, Cecidostiba semifascia, Hobbya stenonota and Mesopolobus amaenus) all attacking Cynipid oak galls. We develop a likelihood method to numerically estimate models of divergence between three populations from multilocus data. We investigate the power of this framework on simulated data, and-using triplet alignments of intronic loci-quantify the support for all possible divergence relationships between refugial populations in the four parasitoids. Although an East to West order of population divergence has highest support in all but one species, we cannot rule out alternative population tree topologies. Comparing the estimated times of population splits between species, we find that one species, M. amaenus, has a significantly older history than the rest of the guild and must have arrived in central Europe at least one glacial cycle prior to other guild members. This suggests that although all four species may share a common origin in the East, they expanded westwards into Europe at different times. © 2012 Blackwell Publishing Ltd.","lang":"eng"}],"title":"A likelihood based comparison of population histories in a parasitoid guild"},{"oa":1,"year":"2012","tmp":{"name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","short":"CC0 (1.0)"},"article_processing_charge":"No","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.0g0fs"}],"month":"06","author":[{"first_name":"Konrad","full_name":"Lohse, Konrad","last_name":"Lohse"},{"last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Stone","full_name":"Stone, Graham","first_name":"Graham"},{"last_name":"Melika","full_name":"Melika, George","first_name":"George"}],"fulldoi":"https://doi.org/10.5061/DRYAD.0G0FS","ddc":["570"],"date_published":"2012-06-08T00:00:00Z","day":"08","doi":"10.5061/DRYAD.0G0FS","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Dryad","status":"public","_id":"13075","type":"research_data_reference","date_updated":"2025-09-30T08:04:02Z","license":"https://creativecommons.org/publicdomain/zero/1.0/","related_material":{"record":[{"id":"2968","status":"public","relation":"used_in_publication"}]},"citation":{"mla":"Lohse, Konrad, et al. <i>Data from: A Likelihood-Based Comparison of Population Histories in a Parasitoid Guild</i>. Dryad, 2012, doi:<a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>.","ama":"Lohse K, Barton NH, Stone G, Melika G. Data from: A likelihood-based comparison of population histories in a parasitoid guild. 2012. doi:<a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>","ista":"Lohse K, Barton NH, Stone G, Melika G. 2012. Data from: A likelihood-based comparison of population histories in a parasitoid guild, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">10.5061/DRYAD.0G0FS</a>.","chicago":"Lohse, Konrad, Nicholas H Barton, Graham Stone, and George Melika. “Data from: A Likelihood-Based Comparison of Population Histories in a Parasitoid Guild.” Dryad, 2012. <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">https://doi.org/10.5061/DRYAD.0G0FS</a>.","apa":"Lohse, K., Barton, N. H., Stone, G., &#38; Melika, G. (2012). Data from: A likelihood-based comparison of population histories in a parasitoid guild. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.0G0FS\">https://doi.org/10.5061/DRYAD.0G0FS</a>","ieee":"K. Lohse, N. H. Barton, G. Stone, and G. Melika, “Data from: A likelihood-based comparison of population histories in a parasitoid guild.” Dryad, 2012.","short":"K. Lohse, N.H. Barton, G. Stone, G. Melika, (2012)."},"abstract":[{"lang":"eng","text":"Little is known about the stability of trophic relationships in complex natural communities over evolutionary timescales. Here, we use sequence data from 18 nuclear loci to reconstruct and compare the intraspecific histories of major Pleistocene refugial populations in the Middle East, the Balkans and Iberia in a guild of four Chalcid parasitoids (Cecidostiba fungosa, C. semifascia, Hobbya stenonota and Mesopolobus amaenus) all attacking Cynipid oak galls. We develop a likelihood method to numerically estimate models of divergence between three populations from multilocus data. We investigate the power of this framework on simulated data, and - using triplet alignments of intronic loci - quantify the support for all possible divergence relationships between refugial populations in the four parasitoids. Although an East to West order of population divergence has highest support in all but one species, we cannot rule out alternative population tree topologies. Comparing the estimated times of population splits between species, we find that one species, M. amaenus, has a significantly older history than the rest of the guild and must have arrived in central Europe at least one glacial cycle prior to other guild members. This suggests that although all four species may share a common origin in the East, they expanded westwards into Europe at different times."}],"title":"Data from: A likelihood-based comparison of population histories in a parasitoid guild","date_created":"2023-05-23T17:01:02Z","department":[{"_id":"NiBa"}]},{"title":"Predicting local adaptation in fragmented plant populations: Implications for restoration genetics","abstract":[{"text":"Understanding patterns and correlates of local adaptation in heterogeneous landscapes can provide important information in the selection of appropriate seed sources for restoration. We assessed the extent of local adaptation of fitness components in 12 population pairs of the perennial herb Rutidosis leptorrhynchoides (Asteraceae) and examined whether spatial scale (0.7-600 km), environmental distance, quantitative (QST) and neutral (FST) genetic differentiation, and size of the local and foreign populations could predict patterns of adaptive differentiation. Local adaptation varied among populations and fitness components. Including all population pairs, local adaptation was observed for seedling survival, but not for biomass, while foreign genotype advantage was observed for reproduction (number of inflorescences). Among population pairs, local adaptation increased with QST and local population size for biomass. QST was associated with environmental distance, suggesting ecological selection for phenotypic divergence. However, low FST and variation in population structure in small populations demonstrates the interaction of gene flow and drift in constraining local adaptation in R. leptorrhynchoides. Our study indicates that for species in heterogeneous landscapes, collecting seed from large populations from similar environments to candidate sites is likely to provide the most appropriate seed sources for restoration.","lang":"eng"}],"file_date_updated":"2020-07-14T12:46:35Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","page":"913 - 924","date_updated":"2025-09-30T08:33:55Z","status":"public","_id":"498","type":"journal_article","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Wiley-Blackwell","doi":"10.1111/j.1752-4571.2012.00284.x","date_published":"2012-12-01T00:00:00Z","day":"01","external_id":{"isi":["000312808900013"]},"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1111/j.1752-4571.2012.00284.x","isi":1,"publist_id":"7322","file":[{"creator":"system","date_created":"2018-12-12T10:10:33Z","relation":"main_file","checksum":"233007138606aca5a2f75f7ae1742f43","date_updated":"2020-07-14T12:46:35Z","file_size":396136,"file_name":"IST-2018-942-v1+1_Pickup_et_al-2012-Evolutionary_Applications.pdf","content_type":"application/pdf","file_id":"4821","access_level":"open_access"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"date_created":"2018-12-11T11:46:48Z","department":[{"_id":"NiBa"}],"publication":"Evolutionary Applications","citation":{"ieee":"M. Pickup, D. Field, D. Rowell, and A. Young, “Predicting local adaptation in fragmented plant populations: Implications for restoration genetics,” <i>Evolutionary Applications</i>, vol. 5, no. 8. Wiley-Blackwell, pp. 913–924, 2012.","apa":"Pickup, M., Field, D., Rowell, D., &#38; Young, A. (2012). Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. <i>Evolutionary Applications</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>","short":"M. Pickup, D. Field, D. Rowell, A. Young, Evolutionary Applications 5 (2012) 913–924.","chicago":"Pickup, Melinda, David Field, David Rowell, and Andrew Young. “Predicting Local Adaptation in Fragmented Plant Populations: Implications for Restoration Genetics.” <i>Evolutionary Applications</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>.","ista":"Pickup M, Field D, Rowell D, Young A. 2012. Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. Evolutionary Applications. 5(8), 913–924.","ama":"Pickup M, Field D, Rowell D, Young A. Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. <i>Evolutionary Applications</i>. 2012;5(8):913-924. doi:<a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">10.1111/j.1752-4571.2012.00284.x</a>","mla":"Pickup, Melinda, et al. “Predicting Local Adaptation in Fragmented Plant Populations: Implications for Restoration Genetics.” <i>Evolutionary Applications</i>, vol. 5, no. 8, Wiley-Blackwell, 2012, pp. 913–24, doi:<a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">10.1111/j.1752-4571.2012.00284.x</a>."},"corr_author":"1","has_accepted_license":"1","volume":5,"quality_controlled":"1","acknowledgement":"We thank Graham Pickup, David Steer, Linda Broadhurst, Lan Li and Carole Elliott for technical assistance. The New\r\nSouth Wales Department of Environment and Climate Change, ACT Parks, Conservation and Lands and the\r\nDepartment of Sustainability and Environment in Victoria provided permits for seed and soil collection. We thank\r\nSpencer C. H. Barrett for comments that improved the quality of the manuscript.\r\n","ddc":["576"],"pubrep_id":"942","author":[{"id":"2C78037E-F248-11E8-B48F-1D18A9856A87","first_name":"Melinda","full_name":"Pickup, Melinda","orcid":"0000-0001-6118-0541","last_name":"Pickup"},{"first_name":"David","orcid":"0000-0002-4014-8478","full_name":"Field, David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","last_name":"Field"},{"first_name":"David","full_name":"Rowell, David","last_name":"Rowell"},{"last_name":"Young","full_name":"Young, Andrew","first_name":"Andrew"}],"publication_status":"published","month":"12","oa_version":"Published Version","issue":"8","intvolume":"         5","year":"2012","oa":1,"article_processing_charge":"No"},{"day":"14","date_published":"2012-11-14T00:00:00Z","fulldoi":"https://doi.org/10.5061/dryad.274b1","author":[{"last_name":"Aeschbacher","full_name":"Aeschbacher, Simon","first_name":"Simon","id":"2D35326E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Andreas","full_name":"Futschik, Andreas","last_name":"Futschik"},{"first_name":"Mark","full_name":"Beaumont, Mark","last_name":"Beaumont"}],"month":"11","oa_version":"Published Version","main_file_link":[{"url":"https://doi.org/10.5061/dryad.274b1","open_access":"1"}],"article_processing_charge":"No","oa":1,"year":"2012","department":[{"_id":"NiBa"}],"title":"Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates","date_created":"2021-07-30T12:36:39Z","abstract":[{"lang":"eng","text":"We propose a two-step procedure for estimating multiple migration rates in an approximate Bayesian computation (ABC) framework, accounting for global nuisance parameters. The approach is not limited to migration, but generally of interest for inference problems with multiple parameters and a modular structure (e.g. independent sets of demes or loci). We condition on a known, but complex demographic model of a spatially subdivided population, motivated by the reintroduction of Alpine ibex (Capra ibex) into Switzerland. In the first step, the global parameters ancestral mutation rate and male mating skew have been estimated for the whole population in Aeschbacher et al. (Genetics 2012; 192: 1027). In the second step, we estimate in this study the migration rates independently for clusters of demes putatively connected by migration. For large clusters (many migration rates), ABC faces the problem of too many summary statistics. We therefore assess by simulation if estimation per pair of demes is a valid alternative. We find that the trade-off between reduced dimensionality for the pairwise estimation on the one hand and lower accuracy due to the assumption of pairwise independence on the other depends on the number of migration rates to be inferred: the accuracy of the pairwise approach increases with the number of parameters, relative to the joint estimation approach. To distinguish between low and zero migration, we perform ABC-type model comparison between a model with migration and one without. Applying the approach to microsatellite data from Alpine ibex, we find no evidence for substantial gene flow via migration, except for one pair of demes in one direction."}],"citation":{"ista":"Aeschbacher S, Futschik A, Beaumont M. 2012. Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates, Dryad, <a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>.","ama":"Aeschbacher S, Futschik A, Beaumont M. Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. 2012. doi:<a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>","mla":"Aeschbacher, Simon, et al. <i>Data from: Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates</i>. Dryad, 2012, doi:<a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>.","ieee":"S. Aeschbacher, A. Futschik, and M. Beaumont, “Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates.” Dryad, 2012.","apa":"Aeschbacher, S., Futschik, A., &#38; Beaumont, M. (2012). Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. Dryad. <a href=\"https://doi.org/10.5061/dryad.274b1\">https://doi.org/10.5061/dryad.274b1</a>","short":"S. Aeschbacher, A. Futschik, M. Beaumont, (2012).","chicago":"Aeschbacher, Simon, Andreas Futschik, and Mark Beaumont. “Data from: Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates.” Dryad, 2012. <a href=\"https://doi.org/10.5061/dryad.274b1\">https://doi.org/10.5061/dryad.274b1</a>."},"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"2944"}]},"date_updated":"2025-09-29T13:25:35Z","type":"research_data_reference","_id":"9758","status":"public","publisher":"Dryad","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","doi":"10.5061/dryad.274b1"},{"external_id":{"isi":["000306478800002"]},"publist_id":"3577","fulldoi":"https://doi.org/10.1111/j.1365-294X.2012.05643.x","isi":1,"language":[{"iso":"eng"}],"day":"01","date_published":"2012-08-01T00:00:00Z","publisher":"Wiley-Blackwell","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","doi":"10.1111/j.1365-294X.2012.05643.x","type":"journal_article","_id":"3122","status":"public","page":"3640 - 3643","date_updated":"2025-09-30T07:58:59Z","title":"Disassortative mating and the maintenance of sexual polymorphism in painted maple","abstract":[{"text":"Since Darwin's pioneering research on plant reproductive biology (e.g. Darwin 1877), understanding the mechanisms maintaining the diverse sexual strategies of plants has remained an important challenge for evolutionary biologists. In some species, populations are sexually polymorphic and contain two or more mating morphs (sex phenotypes). Differences in morphology or phenology among the morphs influence patterns of non-random mating. In these populations, negative frequency-dependent selection arising from disassortative (intermorph) mating is usually required for the evolutionary maintenance of sexual polymorphism, but few studies have demonstrated the required patterns of non-random mating. In the current issue of Molecular Ecology, Shang (2012) make an important contribution to our understanding of how disassortative mating influences sex phenotype ratios in Acer pictum subsp. mono (painted maple), a heterodichogamous, deciduous tree of eastern China. They monitored sex expression in 97 adults and used paternity analysis of open-pollinated seed to examine disassortative mating among three sex phenotypes. Using a deterministic 'pollen transfer' model, Shang et al. present convincing evidence that differences in the degree of disassortative mating in progeny arrays of the sex phenotypes can explain their uneven frequencies in the adult population. This study provides a useful example of how the deployment of genetic markers, demographic monitoring and modelling can be integrated to investigate the maintenance of sexual diversity in plants. ","lang":"eng"}],"article_processing_charge":"No","year":"2012","month":"08","intvolume":"        21","issue":"15","oa_version":"None","publication_status":"published","author":[{"id":"419049E2-F248-11E8-B48F-1D18A9856A87","first_name":"David","full_name":"Field, David","orcid":"0000-0002-4014-8478","last_name":"Field"},{"last_name":"Barrett","first_name":"Spencer","full_name":"Barrett, Spencer"}],"volume":21,"quality_controlled":"1","corr_author":"1","citation":{"ama":"Field D, Barrett S. Disassortative mating and the maintenance of sexual polymorphism in painted maple. <i>Molecular Ecology</i>. 2012;21(15):3640-3643. doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">10.1111/j.1365-294X.2012.05643.x</a>","mla":"Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance of Sexual Polymorphism in Painted Maple.” <i>Molecular Ecology</i>, vol. 21, no. 15, Wiley-Blackwell, 2012, pp. 3640–43, doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">10.1111/j.1365-294X.2012.05643.x</a>.","ista":"Field D, Barrett S. 2012. Disassortative mating and the maintenance of sexual polymorphism in painted maple. Molecular Ecology. 21(15), 3640–3643.","chicago":"Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance of Sexual Polymorphism in Painted Maple.” <i>Molecular Ecology</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">https://doi.org/10.1111/j.1365-294X.2012.05643.x</a>.","short":"D. Field, S. Barrett, Molecular Ecology 21 (2012) 3640–3643.","ieee":"D. Field and S. Barrett, “Disassortative mating and the maintenance of sexual polymorphism in painted maple,” <i>Molecular Ecology</i>, vol. 21, no. 15. Wiley-Blackwell, pp. 3640–3643, 2012.","apa":"Field, D., &#38; Barrett, S. (2012). Disassortative mating and the maintenance of sexual polymorphism in painted maple. <i>Molecular Ecology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">https://doi.org/10.1111/j.1365-294X.2012.05643.x</a>"},"department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2018-12-11T12:01:31Z","publication":"Molecular Ecology"},{"project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152"}],"type":"journal_article","_id":"3131","status":"public","doi":"10.1371/journal.pgen.1002740","publisher":"Public Library of Science","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2020-07-14T12:46:01Z","abstract":[{"text":"In large populations, many beneficial mutations may be simultaneously available and may compete with one another, slowing adaptation. By finding the probability of fixation of a favorable allele in a simple model of a haploid sexual population, we find limits to the rate of adaptive substitution, Λ, that depend on simple parameter combinations. When variance in fitness is low and linkage is loose, the baseline rate of substitution is Λ 0=2NU〈s〉 is the population size, U is the rate of beneficial mutations per genome, and 〈s〉 is their mean selective advantage. Heritable variance ν in log fitness due to unlinked loci reduces Λ by e -4ν under polygamy and e -8ν under monogamy. With a linear genetic map of length R Morgans, interference is yet stronger. We use a scaling argument to show that the density of adaptive substitutions depends on s, N, U, and R only through the baseline density: Λ/R=F(Λ 0/R). Under the approximation that the interference due to different sweeps adds up, we show that Λ/R~(Λ 0/R)/(1+2Λ 0/R), implying that interference prevents the rate of adaptive substitution from exceeding one per centimorgan per 200 generations. Simulations and numerical calculations confirm the scaling argument and confirm the additive approximation for Λ 0/R 1; for higher Λ 0/R, the rate of adaptation grows above R/2, but only very slowly. We also consider the effect of sweeps on neutral diversity and show that, while even occasional sweeps can greatly reduce neutral diversity, this effect saturates as sweeps become more common-diversity can be maintained even in populations experiencing very strong interference. Our results indicate that for some organisms the rate of adaptive substitution may be primarily recombination-limited, depending only weakly on the mutation supply and the strength of selection.","lang":"eng"}],"title":"Limits to the rate of adaptive substitution in sexual populations","date_updated":"2025-09-30T07:56:48Z","license":"https://creativecommons.org/licenses/by/4.0/","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"date_published":"2012-06-07T00:00:00Z","day":"07","fulldoi":"https://doi.org/10.1371/journal.pgen.1002740","publist_id":"3566","isi":1,"file":[{"file_name":"IST-2013-114-v1+1_WeissmanBarton2012.pdf","content_type":"application/pdf","access_level":"open_access","file_id":"4659","relation":"main_file","date_created":"2018-12-12T10:08:00Z","creator":"system","file_size":1284801,"checksum":"729a4becda7d786c4c3db8f9a1f77953","date_updated":"2020-07-14T12:46:01Z"}],"language":[{"iso":"eng"}],"external_id":{"isi":["000305961000014"]},"quality_controlled":"1","ec_funded":1,"volume":8,"acknowledgement":"The work was funded by ERC grant 250152.\r\nWe thank B. Charlesworth, O. Hallatschek, W. G. Hill, R. A. Neher, S. P. Otto, and the anonymous reviewers for their helpful suggestions.","article_number":"e1002740","publication":"PLoS Genetics","department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2018-12-11T12:01:34Z","has_accepted_license":"1","corr_author":"1","citation":{"mla":"Weissman, Daniel, and Nicholas H. Barton. “Limits to the Rate of Adaptive Substitution in Sexual Populations.” <i>PLoS Genetics</i>, vol. 8, no. 6, e1002740, Public Library of Science, 2012, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1002740\">10.1371/journal.pgen.1002740</a>.","ama":"Weissman D, Barton NH. Limits to the rate of adaptive substitution in sexual populations. <i>PLoS Genetics</i>. 2012;8(6). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1002740\">10.1371/journal.pgen.1002740</a>","ista":"Weissman D, Barton NH. 2012. Limits to the rate of adaptive substitution in sexual populations. PLoS Genetics. 8(6), e1002740.","chicago":"Weissman, Daniel, and Nicholas H Barton. “Limits to the Rate of Adaptive Substitution in Sexual Populations.” <i>PLoS Genetics</i>. Public Library of Science, 2012. <a href=\"https://doi.org/10.1371/journal.pgen.1002740\">https://doi.org/10.1371/journal.pgen.1002740</a>.","apa":"Weissman, D., &#38; Barton, N. H. (2012). Limits to the rate of adaptive substitution in sexual populations. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1002740\">https://doi.org/10.1371/journal.pgen.1002740</a>","ieee":"D. Weissman and N. H. Barton, “Limits to the rate of adaptive substitution in sexual populations,” <i>PLoS Genetics</i>, vol. 8, no. 6. Public Library of Science, 2012.","short":"D. Weissman, N.H. Barton, PLoS Genetics 8 (2012)."},"oa_version":"Published Version","issue":"6","intvolume":"         8","month":"06","article_processing_charge":"No","year":"2012","oa":1,"pubrep_id":"114","ddc":["570","576"],"publication_status":"published","author":[{"id":"2D0CE020-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","full_name":"Weissman, Daniel","last_name":"Weissman"},{"last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}]},{"pubrep_id":"99","ddc":["570","576"],"publication_status":"published","author":[{"first_name":"Harold","orcid":"0000-0002-5985-7653","full_name":"Vladar, Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","last_name":"Vladar"}],"intvolume":"         7","oa_version":"Published Version","month":"02","article_processing_charge":"No","year":"2012","oa":1,"publication":"Biology Direct","department":[{"_id":"NiBa"}],"date_created":"2018-12-11T12:01:46Z","has_accepted_license":"1","corr_author":"1","citation":{"mla":"de Vladar, Harold. “Amino Acid Fermentation at the Origin of the Genetic Code.” <i>Biology Direct</i>, vol. 7, 6, BioMed Central, 2012, doi:<a href=\"https://doi.org/10.1186/1745-6150-7-6\">10.1186/1745-6150-7-6</a>.","ama":"de Vladar H. Amino acid fermentation at the origin of the genetic code. <i>Biology Direct</i>. 2012;7. doi:<a href=\"https://doi.org/10.1186/1745-6150-7-6\">10.1186/1745-6150-7-6</a>","ista":"de Vladar H. 2012. Amino acid fermentation at the origin of the genetic code. Biology Direct. 7, 6.","chicago":"Vladar, Harold de. “Amino Acid Fermentation at the Origin of the Genetic Code.” <i>Biology Direct</i>. BioMed Central, 2012. <a href=\"https://doi.org/10.1186/1745-6150-7-6\">https://doi.org/10.1186/1745-6150-7-6</a>.","apa":"de Vladar, H. (2012). Amino acid fermentation at the origin of the genetic code. <i>Biology Direct</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1745-6150-7-6\">https://doi.org/10.1186/1745-6150-7-6</a>","ieee":"H. de Vladar, “Amino acid fermentation at the origin of the genetic code,” <i>Biology Direct</i>, vol. 7. BioMed Central, 2012.","short":"H. de Vladar, Biology Direct 7 (2012)."},"quality_controlled":"1","ec_funded":1,"volume":7,"acknowledgement":"The author was supported by the ERC-2009-AdG Grant for project 250152 SELECTIONINFORMATION. ","article_number":"6","date_published":"2012-02-10T00:00:00Z","day":"10","fulldoi":"https://doi.org/10.1186/1745-6150-7-6","file":[{"file_size":4099536,"checksum":"e511e401e239ef608a7fd79b21a06d78","date_updated":"2020-07-14T12:46:02Z","date_created":"2018-12-12T10:15:44Z","relation":"main_file","creator":"system","access_level":"open_access","file_id":"5166","file_name":"IST-2012-99-v1+1_1745-6150-7-6.pdf","content_type":"application/pdf"}],"publist_id":"3518","isi":1,"language":[{"iso":"eng"}],"external_id":{"isi":["000305269300001"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"file_date_updated":"2020-07-14T12:46:02Z","abstract":[{"text":"There is evidence that the genetic code was established prior to the existence of proteins, when metabolism was powered by ribozymes. Also, early proto-organisms had to rely on simple anaerobic bioenergetic processes. In this work I propose that amino acid fermentation powered metabolism in the RNA world, and that this was facilitated by proto-adapters, the precursors of the tRNAs. Amino acids were used as carbon sources rather than as catalytic or structural elements. In modern bacteria, amino acid fermentation is known as the Stickland reaction. This pathway involves two amino acids: the first undergoes oxidative deamination, and the second acts as an electron acceptor through reductive deamination. This redox reaction results in two keto acids that are employed to synthesise ATP via substrate-level phosphorylation. The Stickland reaction is the basic bioenergetic pathway of some bacteria of the genus Clostridium. Two other facts support Stickland fermentation in the RNA world. First, several Stickland amino acid pairs are synthesised in abiotic amino acid synthesis. This suggests that amino acids that could be used as an energy substrate were freely available. Second, anticodons that have complementary sequences often correspond to amino acids that form Stickland pairs. The main hypothesis of this paper is that pairs of complementary proto-adapters were assigned to Stickland amino acids pairs. There are signatures of this hypothesis in the genetic code. Furthermore, it is argued that the proto-adapters formed double strands that brought amino acid pairs into proximity to facilitate their mutual redox reaction, structurally constraining the anticodon pairs that are assigned to these amino acid pairs. Significance tests which randomise the code are performed to study the extent of the variability of the energetic (ATP) yield. Random assignments can lead to a substantial yield of ATP and maintain enough variability, thus selection can act and refine the assignments into a proto-code that optimises the energetic yield. Monte Carlo simulations are performed to evaluate the establishment of these simple proto-codes, based on amino acid substitutions and codon swapping. In all cases, donor amino acids are assigned to anticodons composed of U+G, and have low redundancy (1-2 codons), whereas acceptor amino acids are assigned to the the remaining codons. These bioenergetic and structural constraints allow for a metabolic role for amino acids before their co-option as catalyst cofactors. Reviewers: this article was reviewed by Prof. William Martin, Prof. Eors Szathmary (nominated by Dr. Gaspar Jekely) and Dr. Adam Kun (nominated by Dr. Sandor Pongor)","lang":"eng"}],"title":"Amino acid fermentation at the origin of the genetic code","date_updated":"2025-09-30T07:51:20Z","project":[{"call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152"}],"type":"journal_article","_id":"3166","status":"public","doi":"10.1186/1745-6150-7-6","publisher":"BioMed Central","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345"},{"intvolume":"        24","oa_version":"None","month":"01","year":"2012","day":"01","date_published":"2012-01-01T00:00:00Z","fulldoi":"https://doi.org/10.1007/978-94-007-4966-5_22","publication_status":"published","publist_id":"3369","language":[{"iso":"eng"}],"author":[{"full_name":"de Vladar, Harold","orcid":"0000-0002-5985-7653","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","last_name":"de Vladar"},{"first_name":"Julian","full_name":"Chela Flores, Julian","last_name":"Chela Flores"}],"quality_controlled":"1","type":"book_chapter","_id":"3277","volume":24,"status":"public","doi":"10.1007/978-94-007-4966-5_22","publisher":"Springer","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication":"Life on Earth and other planetary bodies","abstract":[{"lang":"eng","text":"The problem of the origin of metazoa is becoming more urgent in the context of astrobiology. By now it is clear that clues to the understanding of this crucial transition in the evolution of life can arise in a fourth pathway besides the three possibilities in the quest for simplicity outlined by Bonner in his classical book. In other words, solar system exploration seems to be one way in the long-term to elucidate the simplicity of evolutionary development. We place these ideas in the context of different inheritance systems, namely the genotypic and phenotypic replicators with limited or unlimited heredity, and ask which of these can support multicellular development, and to which degree of complexity. However, the quest for evidence on the evolution of biotas from planets around other stars does not seem to be feasible with present technology with direct visualization of living organisms on exoplanets. But this may be attempted on the Galilean moons of Jupiter where there is a possibility of detecting reliable biomarkers in the next decade with the Europa Jupiter System Mission, in view of recent progress by landing micropenetrators on planetary, or satellite surfaces. Mars is a second possibility in the inner Solar System, in spite of the multiple difficulties faced by the fleet of past, present and future missions. We discuss a series of preliminary ideas for elucidating the origin of metazoan analogues with available instrumentation in potential payloads of feasible space missions to the Galilean moons."}],"department":[{"_id":"NiBa"}],"title":"Can the evolution of multicellularity be anticipated in the exploration of the solar system?","date_created":"2018-12-11T12:02:25Z","alternative_title":["Cellular Origin, Life in Extreme Habitats and Astrobiology"],"date_updated":"2024-10-09T20:54:39Z","page":"387 - 405","corr_author":"1","citation":{"ista":"de Vladar H, Chela Flores J. 2012.Can the evolution of multicellularity be anticipated in the exploration of the solar system? In: Life on Earth and other planetary bodies. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol. 24, 387–405.","mla":"de Vladar, Harold, and Julian Chela Flores. “Can the Evolution of Multicellularity Be Anticipated in the Exploration of the Solar System?” <i>Life on Earth and Other Planetary Bodies</i>, vol. 24, Springer, 2012, pp. 387–405, doi:<a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">10.1007/978-94-007-4966-5_22</a>.","ama":"de Vladar H, Chela Flores J. Can the evolution of multicellularity be anticipated in the exploration of the solar system? In: <i>Life on Earth and Other Planetary Bodies</i>. Vol 24. Springer; 2012:387-405. doi:<a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">10.1007/978-94-007-4966-5_22</a>","short":"H. de Vladar, J. Chela Flores, in:, Life on Earth and Other Planetary Bodies, Springer, 2012, pp. 387–405.","ieee":"H. de Vladar and J. Chela Flores, “Can the evolution of multicellularity be anticipated in the exploration of the solar system?,” in <i>Life on Earth and other planetary bodies</i>, vol. 24, Springer, 2012, pp. 387–405.","apa":"de Vladar, H., &#38; Chela Flores, J. (2012). Can the evolution of multicellularity be anticipated in the exploration of the solar system? In <i>Life on Earth and other planetary bodies</i> (Vol. 24, pp. 387–405). Springer. <a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">https://doi.org/10.1007/978-94-007-4966-5_22</a>","chicago":"Vladar, Harold de, and Julian Chela Flores. “Can the Evolution of Multicellularity Be Anticipated in the Exploration of the Solar System?” In <i>Life on Earth and Other Planetary Bodies</i>, 24:387–405. Springer, 2012. <a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">https://doi.org/10.1007/978-94-007-4966-5_22</a>."}},{"doi":"10.5061/dryad.299h8","publisher":"IST Austria","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","status":"public","_id":"9762","related_material":{"record":[{"id":"3395","relation":"used_in_publication","status":"public"}]},"date_updated":"2025-09-30T08:42:31Z","citation":{"ista":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. 2011. Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas), IST Austria, <a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>.","ama":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas). 2011. doi:<a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>","mla":"Palero, Ferran, et al. <i>Data from: Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster (Palinurus Elephas)</i>. IST Austria, 2011, doi:<a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>.","short":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, M. Pascual, (2011).","ieee":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, and M. Pascual, “Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas).” IST Austria, 2011.","apa":"Palero, F., Abello, P., Macpherson, E., Beaumont, M., &#38; Pascual, M. (2011). Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas). IST Austria. <a href=\"https://doi.org/10.5061/dryad.299h8\">https://doi.org/10.5061/dryad.299h8</a>","chicago":"Palero, Ferran, Pere Abello, Enrique Macpherson, Mark Beaumont, and Marta Pascual. “Data from: Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster (Palinurus Elephas).” IST Austria, 2011. <a href=\"https://doi.org/10.5061/dryad.299h8\">https://doi.org/10.5061/dryad.299h8</a>."},"abstract":[{"text":"Defining population structure and genetic diversity levels is of the utmost importance for developing efficient conservation strategies. Overfishing has caused mean annual catches of the European spiny lobster (Palinurus elephas) to decrease alarmingly along its distribution area. In this context, there is a need for comprehensive studies to evaluate the genetic health of the exploited populations. The present work is based on a set of 10 nuclear markers amplified in 331 individuals from 10 different localities covering most of P. elephas distribution area. Samples from Atlantic and Mediterranean basins showed small but significant differences, indicating that P. elephas populations do not behave as a single panmictic unit but form two partially-overlapping groups. Despite intense overfishing, our dataset did not recover a recent bottleneck signal, and showed a large and stable historical effective size instead. This result could be accounted for by specific life history traits (reproduction and longevity) and the limitations of molecular markers in covering very recent timescales for non temporal samples. Our study emphasizes the necessity of integrating information on effective population sizes and life history parameters when evaluating population connectivity levels from genetic data.","lang":"eng"}],"department":[{"_id":"NiBa"}],"date_created":"2021-08-02T07:11:19Z","title":"Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas)","article_processing_charge":"No","year":"2011","oa":1,"main_file_link":[{"url":"https://doi.org/10.5061/dryad.299h8","open_access":"1"}],"oa_version":"Published Version","month":"05","fulldoi":"https://doi.org/10.5061/dryad.299h8","author":[{"id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87","first_name":"Ferran","orcid":"0000-0002-0343-8329","full_name":"Palero, Ferran","last_name":"Palero"},{"last_name":"Abello","first_name":"Pere","full_name":"Abello, Pere"},{"last_name":"Macpherson","full_name":"Macpherson, Enrique","first_name":"Enrique"},{"last_name":"Beaumont","full_name":"Beaumont, Mark","first_name":"Mark"},{"last_name":"Pascual","full_name":"Pascual, Marta","first_name":"Marta"}],"day":"12","date_published":"2011-05-12T00:00:00Z"},{"author":[{"last_name":"Lohse","full_name":"Lohse, Konrad","first_name":"Konrad"},{"last_name":"Harrison","full_name":"Harrison, Richard","first_name":"Richard"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton"}],"publication_status":"published","year":"2011","oa":1,"article_processing_charge":"No","month":"11","issue":"3","intvolume":"       189","oa_version":"Submitted Version","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213358/","open_access":"1"}],"citation":{"chicago":"Lohse, Konrad, Richard Harrison, and Nicholas H Barton. “A General Method for Calculating Likelihoods under the Coalescent Process.” <i>Genetics</i>. Genetics Society of America, 2011. <a href=\"https://doi.org/10.1534/genetics.111.129569\">https://doi.org/10.1534/genetics.111.129569</a>.","apa":"Lohse, K., Harrison, R., &#38; Barton, N. H. (2011). A general method for calculating likelihoods under the coalescent process. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.111.129569\">https://doi.org/10.1534/genetics.111.129569</a>","ieee":"K. Lohse, R. Harrison, and N. H. Barton, “A general method for calculating likelihoods under the coalescent process,” <i>Genetics</i>, vol. 189, no. 3. Genetics Society of America, pp. 977–987, 2011.","short":"K. Lohse, R. Harrison, N.H. Barton, Genetics 189 (2011) 977–987.","mla":"Lohse, Konrad, et al. “A General Method for Calculating Likelihoods under the Coalescent Process.” <i>Genetics</i>, vol. 189, no. 3, Genetics Society of America, 2011, pp. 977–87, doi:<a href=\"https://doi.org/10.1534/genetics.111.129569\">10.1534/genetics.111.129569</a>.","ama":"Lohse K, Harrison R, Barton NH. A general method for calculating likelihoods under the coalescent process. <i>Genetics</i>. 2011;189(3):977-987. doi:<a href=\"https://doi.org/10.1534/genetics.111.129569\">10.1534/genetics.111.129569</a>","ista":"Lohse K, Harrison R, Barton NH. 2011. A general method for calculating likelihoods under the coalescent process. Genetics. 189(3), 977–987."},"date_created":"2018-12-11T12:02:29Z","scopus_import":"1","department":[{"_id":"NiBa"}],"publication":"Genetics","ec_funded":1,"volume":189,"quality_controlled":"1","external_id":{"isi":["000297020800022"]},"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1534/genetics.111.129569","publist_id":"3355","isi":1,"date_published":"2011-11-01T00:00:00Z","day":"01","page":"977 - 987","date_updated":"2025-09-30T09:21:06Z","title":"A general method for calculating likelihoods under the coalescent process","abstract":[{"text":"Analysis of genomic data requires an efficient way to calculate likelihoods across very large numbers of loci. We describe a general method for finding the distribution of genealogies: we allow migration between demes, splitting of demes [as in the isolation-with-migration (IM) model], and recombination between linked loci. These processes are described by a set of linear recursions for the generating function of branch lengths. Under the infinite-sites model, the probability of any configuration of mutations can be found by differentiating this generating function. Such calculations are feasible for small numbers of sampled genomes: as an example, we show how the generating function can be derived explicitly for three genes under the two-deme IM model. This derivation is done automatically, using Mathematica. Given data from a large number of unlinked and nonrecombining blocks of sequence, these results can be used to find maximum-likelihood estimates of model parameters by tabulating the probabilities of all relevant mutational configurations and then multiplying across loci. The feasibility of the method is demonstrated by applying it to simulated data and to a data set previously analyzed by Wang and Hey (2010) consisting of 26,141 loci sampled from Drosophila simulans and D. melanogaster. Our results suggest that such likelihood calculations are scalable to genomic data as long as the numbers of sampled individuals and mutations per sequence block are small.","lang":"eng"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Genetics Society of America","doi":"10.1534/genetics.111.129569","_id":"3290","status":"public","type":"journal_article","project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","grant_number":"250152"}]},{"language":[{"iso":"eng"}],"fulldoi":"https://doi.org/10.1038/nature09831","publist_id":"3237","isi":1,"external_id":{"isi":["000288702200001"],"pmid":["21430721"]},"date_published":"2011-03-23T00:00:00Z","day":"23","doi":"10.1038/nature09831","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publisher":"Nature Publishing Group","_id":"3372","status":"public","type":"journal_article","date_updated":"2025-09-30T08:58:00Z","page":"E1 - E4","pmid":1,"abstract":[{"text":"Nowak et al.1 argue that inclusive fitness theory has been of little value in explaining the natural world, and that it has led to negligible progress in explaining the evolution of eusociality. However, we believe that their arguments are based upon a misunderstanding of evolutionary theory and a misrepresentation of the empirical literature. We will focus our comments on three general issues.","lang":"eng"}],"title":"Inclusive fitness theory and eusociality","year":"2011","oa":1,"article_processing_charge":"No","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836173/","open_access":"1"}],"intvolume":"       471","oa_version":"Submitted Version","issue":"7339","month":"03","author":[{"last_name":"Abbot","full_name":"Abbot, Patrick","first_name":"Patrick"},{"last_name":"Abe","first_name":"Jun","full_name":"Abe, Jun"},{"last_name":"Alcock","full_name":"Alcock, John","first_name":"John"},{"full_name":"Alizon, Samuel","first_name":"Samuel","last_name":"Alizon"},{"full_name":"Alpedrinha, Joao","first_name":"Joao","last_name":"Alpedrinha"},{"last_name":"Andersson","first_name":"Malte","full_name":"Andersson, Malte"},{"full_name":"Andre, Jean","first_name":"Jean","last_name":"Andre"},{"full_name":"Van Baalen, Minus","first_name":"Minus","last_name":"Van Baalen"},{"last_name":"Balloux","first_name":"Francois","full_name":"Balloux, Francois"},{"last_name":"Balshine","full_name":"Balshine, Sigal","first_name":"Sigal"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton"},{"full_name":"Beukeboom, Leo","first_name":"Leo","last_name":"Beukeboom"},{"full_name":"Biernaskie, Jay","first_name":"Jay","last_name":"Biernaskie"},{"full_name":"Bilde, Trine","first_name":"Trine","last_name":"Bilde"},{"full_name":"Borgia, Gerald","first_name":"Gerald","last_name":"Borgia"},{"last_name":"Breed","full_name":"Breed, Michael","first_name":"Michael"},{"full_name":"Brown, Sam","first_name":"Sam","last_name":"Brown"},{"last_name":"Bshary","full_name":"Bshary, Redouan","first_name":"Redouan"},{"last_name":"Buckling","first_name":"Angus","full_name":"Buckling, Angus"},{"last_name":"Burley","full_name":"Burley, Nancy","first_name":"Nancy"},{"last_name":"Burton Chellew","first_name":"Max","full_name":"Burton Chellew, Max"},{"last_name":"Cant","first_name":"Michael","full_name":"Cant, Michael"},{"last_name":"Chapuisat","first_name":"Michel","full_name":"Chapuisat, Michel"},{"last_name":"Charnov","first_name":"Eric","full_name":"Charnov, Eric"},{"first_name":"Tim","full_name":"Clutton Brock, Tim","last_name":"Clutton Brock"},{"last_name":"Cockburn","first_name":"Andrew","full_name":"Cockburn, Andrew"},{"last_name":"Cole","first_name":"Blaine","full_name":"Cole, Blaine"},{"last_name":"Colegrave","first_name":"Nick","full_name":"Colegrave, Nick"},{"full_name":"Cosmides, Leda","first_name":"Leda","last_name":"Cosmides"},{"last_name":"Couzin","first_name":"Iain","full_name":"Couzin, Iain"},{"full_name":"Coyne, Jerry","first_name":"Jerry","last_name":"Coyne"},{"last_name":"Creel","first_name":"Scott","full_name":"Creel, Scott"},{"full_name":"Crespi, Bernard","first_name":"Bernard","last_name":"Crespi"},{"last_name":"Curry","first_name":"Robert","full_name":"Curry, Robert"},{"last_name":"Dall","first_name":"Sasha","full_name":"Dall, Sasha"},{"first_name":"Troy","full_name":"Day, Troy","last_name":"Day"},{"last_name":"Dickinson","first_name":"Janis","full_name":"Dickinson, Janis"},{"first_name":"Lee","full_name":"Dugatkin, Lee","last_name":"Dugatkin"},{"first_name":"Claire","full_name":"El Mouden, Claire","last_name":"El Mouden"},{"first_name":"Stephen","full_name":"Emlen, Stephen","last_name":"Emlen"},{"last_name":"Evans","first_name":"Jay","full_name":"Evans, Jay"},{"last_name":"Ferriere","first_name":"Regis","full_name":"Ferriere, Regis"},{"full_name":"Field, Jeremy","first_name":"Jeremy","last_name":"Field"},{"full_name":"Foitzik, Susanne","first_name":"Susanne","last_name":"Foitzik"},{"last_name":"Foster","full_name":"Foster, Kevin","first_name":"Kevin"},{"last_name":"Foster","first_name":"William","full_name":"Foster, William"},{"full_name":"Fox, Charles","first_name":"Charles","last_name":"Fox"},{"last_name":"Gadau","first_name":"Juergen","full_name":"Gadau, Juergen"},{"last_name":"Gandon","full_name":"Gandon, Sylvain","first_name":"Sylvain"},{"full_name":"Gardner, Andy","first_name":"Andy","last_name":"Gardner"},{"full_name":"Gardner, Michael","first_name":"Michael","last_name":"Gardner"},{"full_name":"Getty, Thomas","first_name":"Thomas","last_name":"Getty"},{"first_name":"Michael","full_name":"Goodisman, Michael","last_name":"Goodisman"},{"last_name":"Grafen","full_name":"Grafen, Alan","first_name":"Alan"},{"last_name":"Grosberg","full_name":"Grosberg, Rick","first_name":"Rick"},{"last_name":"Grozinger","first_name":"Christina","full_name":"Grozinger, Christina"},{"last_name":"Gouyon","first_name":"Pierre","full_name":"Gouyon, Pierre"},{"last_name":"Gwynne","first_name":"Darryl","full_name":"Gwynne, Darryl"},{"full_name":"Harvey, Paul","first_name":"Paul","last_name":"Harvey"},{"last_name":"Hatchwell","full_name":"Hatchwell, Ben","first_name":"Ben"},{"last_name":"Heinze","full_name":"Heinze, Jürgen","first_name":"Jürgen"},{"full_name":"Helantera, Heikki","first_name":"Heikki","last_name":"Helantera"},{"first_name":"Ken","full_name":"Helms, Ken","last_name":"Helms"},{"first_name":"Kim","full_name":"Hill, Kim","last_name":"Hill"},{"first_name":"Natalie","full_name":"Jiricny, Natalie","last_name":"Jiricny"},{"last_name":"Johnstone","full_name":"Johnstone, Rufus","first_name":"Rufus"},{"full_name":"Kacelnik, Alex","first_name":"Alex","last_name":"Kacelnik"},{"first_name":"E Toby","full_name":"Kiers, E Toby","last_name":"Kiers"},{"first_name":"Hanna","full_name":"Kokko, Hanna","last_name":"Kokko"},{"first_name":"Jan","full_name":"Komdeur, Jan","last_name":"Komdeur"},{"last_name":"Korb","full_name":"Korb, Judith","first_name":"Judith"},{"last_name":"Kronauer","full_name":"Kronauer, Daniel","first_name":"Daniel"},{"last_name":"Kümmerli","full_name":"Kümmerli, Rolf","first_name":"Rolf"},{"full_name":"Lehmann, Laurent","first_name":"Laurent","last_name":"Lehmann"},{"first_name":"Timothy","full_name":"Linksvayer, Timothy","last_name":"Linksvayer"},{"last_name":"Lion","full_name":"Lion, Sébastien","first_name":"Sébastien"},{"first_name":"Bruce","full_name":"Lyon, Bruce","last_name":"Lyon"},{"full_name":"Marshall, James","first_name":"James","last_name":"Marshall"},{"first_name":"Richard","full_name":"Mcelreath, Richard","last_name":"Mcelreath"},{"first_name":"Yannis","full_name":"Michalakis, Yannis","last_name":"Michalakis"},{"full_name":"Michod, Richard","first_name":"Richard","last_name":"Michod"},{"full_name":"Mock, Douglas","first_name":"Douglas","last_name":"Mock"},{"first_name":"Thibaud","full_name":"Monnin, Thibaud","last_name":"Monnin"},{"full_name":"Montgomerie, Robert","first_name":"Robert","last_name":"Montgomerie"},{"last_name":"Moore","full_name":"Moore, Allen","first_name":"Allen"},{"full_name":"Mueller, Ulrich","first_name":"Ulrich","last_name":"Mueller"},{"last_name":"Noë","full_name":"Noë, Ronald","first_name":"Ronald"},{"last_name":"Okasha","full_name":"Okasha, Samir","first_name":"Samir"},{"last_name":"Pamilo","full_name":"Pamilo, Pekka","first_name":"Pekka"},{"last_name":"Parker","first_name":"Geoff","full_name":"Parker, Geoff"},{"full_name":"Pedersen, Jes","first_name":"Jes","last_name":"Pedersen"},{"full_name":"Pen, Ido","first_name":"Ido","last_name":"Pen"},{"first_name":"David","full_name":"Pfennig, David","last_name":"Pfennig"},{"last_name":"Queller","full_name":"Queller, David","first_name":"David"},{"last_name":"Rankin","full_name":"Rankin, Daniel","first_name":"Daniel"},{"last_name":"Reece","full_name":"Reece, Sarah","first_name":"Sarah"},{"last_name":"Reeve","full_name":"Reeve, Hudson","first_name":"Hudson"},{"first_name":"Max","full_name":"Reuter, Max","last_name":"Reuter"},{"last_name":"Roberts","full_name":"Roberts, Gilbert","first_name":"Gilbert"},{"last_name":"Robson","full_name":"Robson, Simon","first_name":"Simon"},{"full_name":"Roze, Denis","first_name":"Denis","last_name":"Roze"},{"last_name":"Rousset","first_name":"Francois","full_name":"Rousset, Francois"},{"full_name":"Rueppell, Olav","first_name":"Olav","last_name":"Rueppell"},{"last_name":"Sachs","first_name":"Joel","full_name":"Sachs, Joel"},{"full_name":"Santorelli, Lorenzo","first_name":"Lorenzo","last_name":"Santorelli"},{"first_name":"Paul","full_name":"Schmid Hempel, Paul","last_name":"Schmid Hempel"},{"last_name":"Schwarz","full_name":"Schwarz, Michael","first_name":"Michael"},{"first_name":"Tom","full_name":"Scott Phillips, Tom","last_name":"Scott Phillips"},{"last_name":"Shellmann Sherman","first_name":"Janet","full_name":"Shellmann Sherman, Janet"},{"last_name":"Sherman","first_name":"Paul","full_name":"Sherman, Paul"},{"first_name":"David","full_name":"Shuker, David","last_name":"Shuker"},{"full_name":"Smith, Jeff","first_name":"Jeff","last_name":"Smith"},{"last_name":"Spagna","full_name":"Spagna, Joseph","first_name":"Joseph"},{"full_name":"Strassmann, Beverly","first_name":"Beverly","last_name":"Strassmann"},{"first_name":"Andrew","full_name":"Suarez, Andrew","last_name":"Suarez"},{"last_name":"Sundström","first_name":"Liselotte","full_name":"Sundström, Liselotte"},{"first_name":"Michael","full_name":"Taborsky, Michael","last_name":"Taborsky"},{"first_name":"Peter","full_name":"Taylor, Peter","last_name":"Taylor"},{"full_name":"Thompson, Graham","first_name":"Graham","last_name":"Thompson"},{"first_name":"John","full_name":"Tooby, John","last_name":"Tooby"},{"last_name":"Tsutsui","full_name":"Tsutsui, Neil","first_name":"Neil"},{"last_name":"Tsuji","full_name":"Tsuji, Kazuki","first_name":"Kazuki"},{"first_name":"Stefano","full_name":"Turillazzi, Stefano","last_name":"Turillazzi"},{"full_name":"Úbeda, Francisco","first_name":"Francisco","last_name":"Úbeda"},{"last_name":"Vargo","full_name":"Vargo, Edward","first_name":"Edward"},{"last_name":"Voelkl","first_name":"Bernard","full_name":"Voelkl, Bernard"},{"full_name":"Wenseleers, Tom","first_name":"Tom","last_name":"Wenseleers"},{"first_name":"Stuart","full_name":"West, Stuart","last_name":"West"},{"full_name":"West Eberhard, Mary","first_name":"Mary","last_name":"West Eberhard"},{"first_name":"David","full_name":"Westneat, David","last_name":"Westneat"},{"full_name":"Wiernasz, Diane","first_name":"Diane","last_name":"Wiernasz"},{"last_name":"Wild","first_name":"Geoff","full_name":"Wild, Geoff"},{"full_name":"Wrangham, Richard","first_name":"Richard","last_name":"Wrangham"},{"first_name":"Andrew","full_name":"Young, Andrew","last_name":"Young"},{"first_name":"David","full_name":"Zeh, David","last_name":"Zeh"},{"last_name":"Zeh","full_name":"Zeh, Jeanne","first_name":"Jeanne"},{"full_name":"Zink, Andrew","first_name":"Andrew","last_name":"Zink"}],"publication_status":"published","quality_controlled":"1","volume":471,"citation":{"ista":"Abbot P et al. 2011. Inclusive fitness theory and eusociality. Nature. 471(7339), E1–E4.","mla":"Abbot, Patrick, et al. “Inclusive Fitness Theory and Eusociality.” <i>Nature</i>, vol. 471, no. 7339, Nature Publishing Group, 2011, pp. E1–4, doi:<a href=\"https://doi.org/10.1038/nature09831\">10.1038/nature09831</a>.","ama":"Abbot P, Abe J, Alcock J, et al. Inclusive fitness theory and eusociality. <i>Nature</i>. 2011;471(7339):E1-E4. doi:<a href=\"https://doi.org/10.1038/nature09831\">10.1038/nature09831</a>","ieee":"P. Abbot <i>et al.</i>, “Inclusive fitness theory and eusociality,” <i>Nature</i>, vol. 471, no. 7339. Nature Publishing Group, pp. E1–E4, 2011.","apa":"Abbot, P., Abe, J., Alcock, J., Alizon, S., Alpedrinha, J., Andersson, M., … Zink, A. (2011). Inclusive fitness theory and eusociality. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature09831\">https://doi.org/10.1038/nature09831</a>","short":"P. Abbot, J. Abe, J. Alcock, S. Alizon, J. Alpedrinha, M. Andersson, J. 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