[{"month":"12","volume":5,"language":[{"iso":"eng"}],"author":[{"orcid":"0000-0001-6118-0541","full_name":"Pickup, Melinda","last_name":"Pickup","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","first_name":"Melinda"},{"first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","last_name":"Field","full_name":"Field, David","orcid":"0000-0002-4014-8478"},{"full_name":"Rowell, David","first_name":"David","last_name":"Rowell"},{"last_name":"Young","first_name":"Andrew","full_name":"Young, Andrew"}],"isi":1,"citation":{"ama":"Pickup M, Field D, Rowell D, Young A. Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. <i>Evolutionary Applications</i>. 2012;5(8):913-924. doi:<a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">10.1111/j.1752-4571.2012.00284.x</a>","apa":"Pickup, M., Field, D., Rowell, D., &#38; Young, A. (2012). Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. <i>Evolutionary Applications</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>","ista":"Pickup M, Field D, Rowell D, Young A. 2012. Predicting local adaptation in fragmented plant populations: Implications for restoration genetics. Evolutionary Applications. 5(8), 913–924.","chicago":"Pickup, Melinda, David Field, David Rowell, and Andrew Young. “Predicting Local Adaptation in Fragmented Plant Populations: Implications for Restoration Genetics.” <i>Evolutionary Applications</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">https://doi.org/10.1111/j.1752-4571.2012.00284.x</a>.","short":"M. Pickup, D. Field, D. Rowell, A. Young, Evolutionary Applications 5 (2012) 913–924.","mla":"Pickup, Melinda, et al. “Predicting Local Adaptation in Fragmented Plant Populations: Implications for Restoration Genetics.” <i>Evolutionary Applications</i>, vol. 5, no. 8, Wiley-Blackwell, 2012, pp. 913–24, doi:<a href=\"https://doi.org/10.1111/j.1752-4571.2012.00284.x\">10.1111/j.1752-4571.2012.00284.x</a>.","ieee":"M. Pickup, D. Field, D. Rowell, and A. Young, “Predicting local adaptation in fragmented plant populations: Implications for restoration genetics,” <i>Evolutionary Applications</i>, vol. 5, no. 8. Wiley-Blackwell, pp. 913–924, 2012."},"article_processing_charge":"No","page":"913 - 924","publist_id":"7322","oa":1,"acknowledgement":"We thank Graham Pickup, David Steer, Linda Broadhurst, Lan Li and Carole Elliott for technical assistance. The New\r\nSouth Wales Department of Environment and Climate Change, ACT Parks, Conservation and Lands and the\r\nDepartment of Sustainability and Environment in Victoria provided permits for seed and soil collection. We thank\r\nSpencer C. H. Barrett for comments that improved the quality of the manuscript.\r\n","day":"01","quality_controlled":"1","abstract":[{"text":"Understanding patterns and correlates of local adaptation in heterogeneous landscapes can provide important information in the selection of appropriate seed sources for restoration. We assessed the extent of local adaptation of fitness components in 12 population pairs of the perennial herb Rutidosis leptorrhynchoides (Asteraceae) and examined whether spatial scale (0.7-600 km), environmental distance, quantitative (QST) and neutral (FST) genetic differentiation, and size of the local and foreign populations could predict patterns of adaptive differentiation. Local adaptation varied among populations and fitness components. Including all population pairs, local adaptation was observed for seedling survival, but not for biomass, while foreign genotype advantage was observed for reproduction (number of inflorescences). Among population pairs, local adaptation increased with QST and local population size for biomass. QST was associated with environmental distance, suggesting ecological selection for phenotypic divergence. However, low FST and variation in population structure in small populations demonstrates the interaction of gene flow and drift in constraining local adaptation in R. leptorrhynchoides. Our study indicates that for species in heterogeneous landscapes, collecting seed from large populations from similar environments to candidate sites is likely to provide the most appropriate seed sources for restoration.","lang":"eng"}],"intvolume":"         5","publication":"Evolutionary Applications","publication_status":"published","title":"Predicting local adaptation in fragmented plant populations: Implications for restoration genetics","corr_author":"1","has_accepted_license":"1","publisher":"Wiley-Blackwell","type":"journal_article","issue":"8","ddc":["576"],"year":"2012","date_published":"2012-12-01T00:00:00Z","pubrep_id":"942","status":"public","date_created":"2018-12-11T11:46:48Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","external_id":{"isi":["000312808900013"]},"date_updated":"2025-09-30T08:33:55Z","department":[{"_id":"NiBa"}],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:46:35Z","_id":"498","file":[{"access_level":"open_access","date_updated":"2020-07-14T12:46:35Z","checksum":"233007138606aca5a2f75f7ae1742f43","file_name":"IST-2018-942-v1+1_Pickup_et_al-2012-Evolutionary_Applications.pdf","file_size":396136,"file_id":"4821","creator":"system","relation":"main_file","date_created":"2018-12-12T10:10:33Z","content_type":"application/pdf"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"doi":"10.1111/j.1752-4571.2012.00284.x"},{"oa":1,"date_created":"2021-07-30T12:36:39Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","author":[{"full_name":"Aeschbacher, Simon","id":"2D35326E-F248-11E8-B48F-1D18A9856A87","first_name":"Simon","last_name":"Aeschbacher"},{"last_name":"Futschik","first_name":"Andreas","full_name":"Futschik, Andreas"},{"first_name":"Mark","last_name":"Beaumont","full_name":"Beaumont, Mark"}],"status":"public","citation":{"short":"S. Aeschbacher, A. Futschik, M. Beaumont, (2012).","apa":"Aeschbacher, S., Futschik, A., &#38; Beaumont, M. (2012). Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. Dryad. <a href=\"https://doi.org/10.5061/dryad.274b1\">https://doi.org/10.5061/dryad.274b1</a>","ama":"Aeschbacher S, Futschik A, Beaumont M. Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates. 2012. doi:<a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>","chicago":"Aeschbacher, Simon, Andreas Futschik, and Mark Beaumont. “Data from: Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates.” Dryad, 2012. <a href=\"https://doi.org/10.5061/dryad.274b1\">https://doi.org/10.5061/dryad.274b1</a>.","ista":"Aeschbacher S, Futschik A, Beaumont M. 2012. Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates, Dryad, <a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>.","mla":"Aeschbacher, Simon, et al. <i>Data from: Approximate Bayesian Computation for Modular Inference Problems with Many Parameters: The Example of Migration Rates</i>. Dryad, 2012, doi:<a href=\"https://doi.org/10.5061/dryad.274b1\">10.5061/dryad.274b1</a>.","ieee":"S. Aeschbacher, A. Futschik, and M. Beaumont, “Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates.” Dryad, 2012."},"date_published":"2012-11-14T00:00:00Z","article_processing_charge":"No","year":"2012","month":"11","type":"research_data_reference","publisher":"Dryad","doi":"10.5061/dryad.274b1","oa_version":"Published Version","abstract":[{"lang":"eng","text":"We propose a two-step procedure for estimating multiple migration rates in an approximate Bayesian computation (ABC) framework, accounting for global nuisance parameters. The approach is not limited to migration, but generally of interest for inference problems with multiple parameters and a modular structure (e.g. independent sets of demes or loci). We condition on a known, but complex demographic model of a spatially subdivided population, motivated by the reintroduction of Alpine ibex (Capra ibex) into Switzerland. In the first step, the global parameters ancestral mutation rate and male mating skew have been estimated for the whole population in Aeschbacher et al. (Genetics 2012; 192: 1027). In the second step, we estimate in this study the migration rates independently for clusters of demes putatively connected by migration. For large clusters (many migration rates), ABC faces the problem of too many summary statistics. We therefore assess by simulation if estimation per pair of demes is a valid alternative. We find that the trade-off between reduced dimensionality for the pairwise estimation on the one hand and lower accuracy due to the assumption of pairwise independence on the other depends on the number of migration rates to be inferred: the accuracy of the pairwise approach increases with the number of parameters, relative to the joint estimation approach. To distinguish between low and zero migration, we perform ABC-type model comparison between a model with migration and one without. Applying the approach to microsatellite data from Alpine ibex, we find no evidence for substantial gene flow via migration, except for one pair of demes in one direction."}],"_id":"9758","title":"Data from: Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates","department":[{"_id":"NiBa"}],"main_file_link":[{"url":"https://doi.org/10.5061/dryad.274b1","open_access":"1"}],"day":"14","date_updated":"2025-09-29T13:25:35Z","related_material":{"record":[{"id":"2944","relation":"used_in_publication","status":"public"}]}},{"quality_controlled":"1","day":"01","title":"Disassortative mating and the maintenance of sexual polymorphism in painted maple","corr_author":"1","publication_status":"published","publication":"Molecular Ecology","intvolume":"        21","abstract":[{"lang":"eng","text":"Since Darwin's pioneering research on plant reproductive biology (e.g. Darwin 1877), understanding the mechanisms maintaining the diverse sexual strategies of plants has remained an important challenge for evolutionary biologists. In some species, populations are sexually polymorphic and contain two or more mating morphs (sex phenotypes). Differences in morphology or phenology among the morphs influence patterns of non-random mating. In these populations, negative frequency-dependent selection arising from disassortative (intermorph) mating is usually required for the evolutionary maintenance of sexual polymorphism, but few studies have demonstrated the required patterns of non-random mating. In the current issue of Molecular Ecology, Shang (2012) make an important contribution to our understanding of how disassortative mating influences sex phenotype ratios in Acer pictum subsp. mono (painted maple), a heterodichogamous, deciduous tree of eastern China. They monitored sex expression in 97 adults and used paternity analysis of open-pollinated seed to examine disassortative mating among three sex phenotypes. Using a deterministic 'pollen transfer' model, Shang et al. present convincing evidence that differences in the degree of disassortative mating in progeny arrays of the sex phenotypes can explain their uneven frequencies in the adult population. This study provides a useful example of how the deployment of genetic markers, demographic monitoring and modelling can be integrated to investigate the maintenance of sexual diversity in plants. "}],"volume":21,"scopus_import":"1","month":"08","publist_id":"3577","page":"3640 - 3643","article_processing_charge":"No","isi":1,"citation":{"mla":"Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance of Sexual Polymorphism in Painted Maple.” <i>Molecular Ecology</i>, vol. 21, no. 15, Wiley-Blackwell, 2012, pp. 3640–43, doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">10.1111/j.1365-294X.2012.05643.x</a>.","ieee":"D. Field and S. Barrett, “Disassortative mating and the maintenance of sexual polymorphism in painted maple,” <i>Molecular Ecology</i>, vol. 21, no. 15. Wiley-Blackwell, pp. 3640–3643, 2012.","short":"D. Field, S. Barrett, Molecular Ecology 21 (2012) 3640–3643.","chicago":"Field, David, and Spencer Barrett. “Disassortative Mating and the Maintenance of Sexual Polymorphism in Painted Maple.” <i>Molecular Ecology</i>. Wiley-Blackwell, 2012. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">https://doi.org/10.1111/j.1365-294X.2012.05643.x</a>.","ista":"Field D, Barrett S. 2012. Disassortative mating and the maintenance of sexual polymorphism in painted maple. Molecular Ecology. 21(15), 3640–3643.","ama":"Field D, Barrett S. Disassortative mating and the maintenance of sexual polymorphism in painted maple. <i>Molecular Ecology</i>. 2012;21(15):3640-3643. doi:<a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">10.1111/j.1365-294X.2012.05643.x</a>","apa":"Field, D., &#38; Barrett, S. (2012). Disassortative mating and the maintenance of sexual polymorphism in painted maple. <i>Molecular Ecology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1365-294X.2012.05643.x\">https://doi.org/10.1111/j.1365-294X.2012.05643.x</a>"},"author":[{"full_name":"Field, David","orcid":"0000-0002-4014-8478","first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","last_name":"Field"},{"first_name":"Spencer","last_name":"Barrett","full_name":"Barrett, Spencer"}],"language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"date_updated":"2025-09-30T07:58:59Z","external_id":{"isi":["000306478800002"]},"doi":"10.1111/j.1365-294X.2012.05643.x","_id":"3122","oa_version":"None","year":"2012","issue":"15","type":"journal_article","publisher":"Wiley-Blackwell","date_created":"2018-12-11T12:01:31Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","date_published":"2012-08-01T00:00:00Z"},{"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"author":[{"full_name":"Weissman, Daniel","id":"2D0CE020-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel","last_name":"Weissman"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"}],"article_processing_charge":"No","isi":1,"citation":{"ieee":"D. Weissman and N. H. Barton, “Limits to the rate of adaptive substitution in sexual populations,” <i>PLoS Genetics</i>, vol. 8, no. 6. Public Library of Science, 2012.","mla":"Weissman, Daniel, and Nicholas H. Barton. “Limits to the Rate of Adaptive Substitution in Sexual Populations.” <i>PLoS Genetics</i>, vol. 8, no. 6, e1002740, Public Library of Science, 2012, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1002740\">10.1371/journal.pgen.1002740</a>.","ama":"Weissman D, Barton NH. Limits to the rate of adaptive substitution in sexual populations. <i>PLoS Genetics</i>. 2012;8(6). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1002740\">10.1371/journal.pgen.1002740</a>","apa":"Weissman, D., &#38; Barton, N. H. (2012). Limits to the rate of adaptive substitution in sexual populations. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1002740\">https://doi.org/10.1371/journal.pgen.1002740</a>","ista":"Weissman D, Barton NH. 2012. Limits to the rate of adaptive substitution in sexual populations. PLoS Genetics. 8(6), e1002740.","chicago":"Weissman, Daniel, and Nicholas H Barton. “Limits to the Rate of Adaptive Substitution in Sexual Populations.” <i>PLoS Genetics</i>. Public Library of Science, 2012. <a href=\"https://doi.org/10.1371/journal.pgen.1002740\">https://doi.org/10.1371/journal.pgen.1002740</a>.","short":"D. Weissman, N.H. Barton, PLoS Genetics 8 (2012)."},"publist_id":"3566","oa":1,"acknowledgement":"The work was funded by ERC grant 250152.\r\nWe thank B. Charlesworth, O. Hallatschek, W. G. Hill, R. A. Neher, S. P. Otto, and the anonymous reviewers for their helpful suggestions.","scopus_import":"1","month":"06","volume":8,"intvolume":"         8","abstract":[{"text":"In large populations, many beneficial mutations may be simultaneously available and may compete with one another, slowing adaptation. By finding the probability of fixation of a favorable allele in a simple model of a haploid sexual population, we find limits to the rate of adaptive substitution, Λ, that depend on simple parameter combinations. When variance in fitness is low and linkage is loose, the baseline rate of substitution is Λ 0=2NU〈s〉 is the population size, U is the rate of beneficial mutations per genome, and 〈s〉 is their mean selective advantage. Heritable variance ν in log fitness due to unlinked loci reduces Λ by e -4ν under polygamy and e -8ν under monogamy. With a linear genetic map of length R Morgans, interference is yet stronger. We use a scaling argument to show that the density of adaptive substitutions depends on s, N, U, and R only through the baseline density: Λ/R=F(Λ 0/R). Under the approximation that the interference due to different sweeps adds up, we show that Λ/R~(Λ 0/R)/(1+2Λ 0/R), implying that interference prevents the rate of adaptive substitution from exceeding one per centimorgan per 200 generations. Simulations and numerical calculations confirm the scaling argument and confirm the additive approximation for Λ 0/R 1; for higher Λ 0/R, the rate of adaptation grows above R/2, but only very slowly. We also consider the effect of sweeps on neutral diversity and show that, while even occasional sweeps can greatly reduce neutral diversity, this effect saturates as sweeps become more common-diversity can be maintained even in populations experiencing very strong interference. Our results indicate that for some organisms the rate of adaptive substitution may be primarily recombination-limited, depending only weakly on the mutation supply and the strength of selection.","lang":"eng"}],"publication":"PLoS Genetics","publication_status":"published","title":"Limits to the rate of adaptive substitution in sexual populations","corr_author":"1","has_accepted_license":"1","ec_funded":1,"day":"07","quality_controlled":"1","date_published":"2012-06-07T00:00:00Z","pubrep_id":"114","status":"public","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:01:34Z","publisher":"Public Library of Science","type":"journal_article","issue":"6","ddc":["570","576"],"year":"2012","oa_version":"Published Version","file_date_updated":"2020-07-14T12:46:01Z","_id":"3131","file":[{"date_created":"2018-12-12T10:08:00Z","content_type":"application/pdf","relation":"main_file","creator":"system","file_size":1284801,"file_name":"IST-2013-114-v1+1_WeissmanBarton2012.pdf","file_id":"4659","checksum":"729a4becda7d786c4c3db8f9a1f77953","access_level":"open_access","date_updated":"2020-07-14T12:46:01Z"}],"article_number":"e1002740","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"doi":"10.1371/journal.pgen.1002740","external_id":{"isi":["000305961000014"]},"date_updated":"2025-09-30T07:56:48Z","department":[{"_id":"NiBa"}]},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:01:46Z","date_published":"2012-02-10T00:00:00Z","pubrep_id":"99","status":"public","year":"2012","ddc":["570","576"],"publisher":"BioMed Central","type":"journal_article","doi":"10.1186/1745-6150-7-6","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"_id":"3166","article_number":"6","file":[{"relation":"main_file","content_type":"application/pdf","date_created":"2018-12-12T10:15:44Z","checksum":"e511e401e239ef608a7fd79b21a06d78","date_updated":"2020-07-14T12:46:02Z","access_level":"open_access","creator":"system","file_id":"5166","file_name":"IST-2012-99-v1+1_1745-6150-7-6.pdf","file_size":4099536}],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:46:02Z","department":[{"_id":"NiBa"}],"date_updated":"2025-09-30T07:51:20Z","external_id":{"isi":["000305269300001"]},"acknowledgement":"The author was supported by the ERC-2009-AdG Grant for project 250152 SELECTIONINFORMATION. ","publist_id":"3518","oa":1,"article_processing_charge":"No","citation":{"chicago":"Vladar, Harold de. “Amino Acid Fermentation at the Origin of the Genetic Code.” <i>Biology Direct</i>. BioMed Central, 2012. <a href=\"https://doi.org/10.1186/1745-6150-7-6\">https://doi.org/10.1186/1745-6150-7-6</a>.","ista":"de Vladar H. 2012. Amino acid fermentation at the origin of the genetic code. Biology Direct. 7, 6.","apa":"de Vladar, H. (2012). Amino acid fermentation at the origin of the genetic code. <i>Biology Direct</i>. BioMed Central. <a href=\"https://doi.org/10.1186/1745-6150-7-6\">https://doi.org/10.1186/1745-6150-7-6</a>","ama":"de Vladar H. Amino acid fermentation at the origin of the genetic code. <i>Biology Direct</i>. 2012;7. doi:<a href=\"https://doi.org/10.1186/1745-6150-7-6\">10.1186/1745-6150-7-6</a>","short":"H. de Vladar, Biology Direct 7 (2012).","mla":"de Vladar, Harold. “Amino Acid Fermentation at the Origin of the Genetic Code.” <i>Biology Direct</i>, vol. 7, 6, BioMed Central, 2012, doi:<a href=\"https://doi.org/10.1186/1745-6150-7-6\">10.1186/1745-6150-7-6</a>.","ieee":"H. de Vladar, “Amino acid fermentation at the origin of the genetic code,” <i>Biology Direct</i>, vol. 7. BioMed Central, 2012."},"isi":1,"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation"}],"author":[{"last_name":"Vladar","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5985-7653","full_name":"Vladar, Harold"}],"month":"02","volume":7,"ec_funded":1,"title":"Amino acid fermentation at the origin of the genetic code","publication_status":"published","corr_author":"1","has_accepted_license":"1","intvolume":"         7","abstract":[{"text":"There is evidence that the genetic code was established prior to the existence of proteins, when metabolism was powered by ribozymes. Also, early proto-organisms had to rely on simple anaerobic bioenergetic processes. In this work I propose that amino acid fermentation powered metabolism in the RNA world, and that this was facilitated by proto-adapters, the precursors of the tRNAs. Amino acids were used as carbon sources rather than as catalytic or structural elements. In modern bacteria, amino acid fermentation is known as the Stickland reaction. This pathway involves two amino acids: the first undergoes oxidative deamination, and the second acts as an electron acceptor through reductive deamination. This redox reaction results in two keto acids that are employed to synthesise ATP via substrate-level phosphorylation. The Stickland reaction is the basic bioenergetic pathway of some bacteria of the genus Clostridium. Two other facts support Stickland fermentation in the RNA world. First, several Stickland amino acid pairs are synthesised in abiotic amino acid synthesis. This suggests that amino acids that could be used as an energy substrate were freely available. Second, anticodons that have complementary sequences often correspond to amino acids that form Stickland pairs. The main hypothesis of this paper is that pairs of complementary proto-adapters were assigned to Stickland amino acids pairs. There are signatures of this hypothesis in the genetic code. Furthermore, it is argued that the proto-adapters formed double strands that brought amino acid pairs into proximity to facilitate their mutual redox reaction, structurally constraining the anticodon pairs that are assigned to these amino acid pairs. Significance tests which randomise the code are performed to study the extent of the variability of the energetic (ATP) yield. Random assignments can lead to a substantial yield of ATP and maintain enough variability, thus selection can act and refine the assignments into a proto-code that optimises the energetic yield. Monte Carlo simulations are performed to evaluate the establishment of these simple proto-codes, based on amino acid substitutions and codon swapping. In all cases, donor amino acids are assigned to anticodons composed of U+G, and have low redundancy (1-2 codons), whereas acceptor amino acids are assigned to the the remaining codons. These bioenergetic and structural constraints allow for a metabolic role for amino acids before their co-option as catalyst cofactors. Reviewers: this article was reviewed by Prof. William Martin, Prof. Eors Szathmary (nominated by Dr. Gaspar Jekely) and Dr. Adam Kun (nominated by Dr. Sandor Pongor)","lang":"eng"}],"publication":"Biology Direct","quality_controlled":"1","day":"10"},{"date_created":"2018-12-11T12:02:25Z","publist_id":"3369","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"author":[{"orcid":"0000-0002-5985-7653","full_name":"de Vladar, Harold","last_name":"de Vladar","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Chela Flores","first_name":"Julian","full_name":"Chela Flores, Julian"}],"date_published":"2012-01-01T00:00:00Z","citation":{"mla":"de Vladar, Harold, and Julian Chela Flores. “Can the Evolution of Multicellularity Be Anticipated in the Exploration of the Solar System?” <i>Life on Earth and Other Planetary Bodies</i>, vol. 24, Springer, 2012, pp. 387–405, doi:<a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">10.1007/978-94-007-4966-5_22</a>.","ieee":"H. de Vladar and J. Chela Flores, “Can the evolution of multicellularity be anticipated in the exploration of the solar system?,” in <i>Life on Earth and other planetary bodies</i>, vol. 24, Springer, 2012, pp. 387–405.","short":"H. de Vladar, J. Chela Flores, in:, Life on Earth and Other Planetary Bodies, Springer, 2012, pp. 387–405.","chicago":"Vladar, Harold de, and Julian Chela Flores. “Can the Evolution of Multicellularity Be Anticipated in the Exploration of the Solar System?” In <i>Life on Earth and Other Planetary Bodies</i>, 24:387–405. Springer, 2012. <a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">https://doi.org/10.1007/978-94-007-4966-5_22</a>.","ista":"de Vladar H, Chela Flores J. 2012.Can the evolution of multicellularity be anticipated in the exploration of the solar system? In: Life on Earth and other planetary bodies. Cellular Origin, Life in Extreme Habitats and Astrobiology, vol. 24, 387–405.","apa":"de Vladar, H., &#38; Chela Flores, J. (2012). Can the evolution of multicellularity be anticipated in the exploration of the solar system? In <i>Life on Earth and other planetary bodies</i> (Vol. 24, pp. 387–405). Springer. <a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">https://doi.org/10.1007/978-94-007-4966-5_22</a>","ama":"de Vladar H, Chela Flores J. Can the evolution of multicellularity be anticipated in the exploration of the solar system? In: <i>Life on Earth and Other Planetary Bodies</i>. Vol 24. Springer; 2012:387-405. doi:<a href=\"https://doi.org/10.1007/978-94-007-4966-5_22\">10.1007/978-94-007-4966-5_22</a>"},"status":"public","page":"387 - 405","month":"01","volume":24,"year":"2012","publisher":"Springer","type":"book_chapter","doi":"10.1007/978-94-007-4966-5_22","abstract":[{"lang":"eng","text":"The problem of the origin of metazoa is becoming more urgent in the context of astrobiology. By now it is clear that clues to the understanding of this crucial transition in the evolution of life can arise in a fourth pathway besides the three possibilities in the quest for simplicity outlined by Bonner in his classical book. In other words, solar system exploration seems to be one way in the long-term to elucidate the simplicity of evolutionary development. We place these ideas in the context of different inheritance systems, namely the genotypic and phenotypic replicators with limited or unlimited heredity, and ask which of these can support multicellular development, and to which degree of complexity. However, the quest for evidence on the evolution of biotas from planets around other stars does not seem to be feasible with present technology with direct visualization of living organisms on exoplanets. But this may be attempted on the Galilean moons of Jupiter where there is a possibility of detecting reliable biomarkers in the next decade with the Europa Jupiter System Mission, in view of recent progress by landing micropenetrators on planetary, or satellite surfaces. Mars is a second possibility in the inner Solar System, in spite of the multiple difficulties faced by the fleet of past, present and future missions. We discuss a series of preliminary ideas for elucidating the origin of metazoan analogues with available instrumentation in potential payloads of feasible space missions to the Galilean moons."}],"oa_version":"None","intvolume":"        24","publication":"Life on Earth and other planetary bodies","corr_author":"1","_id":"3277","title":"Can the evolution of multicellularity be anticipated in the exploration of the solar system?","publication_status":"published","alternative_title":["Cellular Origin, Life in Extreme Habitats and Astrobiology"],"department":[{"_id":"NiBa"}],"day":"01","date_updated":"2024-10-09T20:54:39Z","quality_controlled":"1"},{"oa":1,"date_created":"2021-08-02T07:11:19Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","status":"public","citation":{"mla":"Palero, Ferran, et al. <i>Data from: Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster (Palinurus Elephas)</i>. IST Austria, 2011, doi:<a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>.","ieee":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, and M. Pascual, “Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas).” IST Austria, 2011.","apa":"Palero, F., Abello, P., Macpherson, E., Beaumont, M., &#38; Pascual, M. (2011). Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas). IST Austria. <a href=\"https://doi.org/10.5061/dryad.299h8\">https://doi.org/10.5061/dryad.299h8</a>","ama":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas). 2011. doi:<a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>","chicago":"Palero, Ferran, Pere Abello, Enrique Macpherson, Mark Beaumont, and Marta Pascual. “Data from: Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster (Palinurus Elephas).” IST Austria, 2011. <a href=\"https://doi.org/10.5061/dryad.299h8\">https://doi.org/10.5061/dryad.299h8</a>.","ista":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. 2011. Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas), IST Austria, <a href=\"https://doi.org/10.5061/dryad.299h8\">10.5061/dryad.299h8</a>.","short":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, M. Pascual, (2011)."},"date_published":"2011-05-12T00:00:00Z","article_processing_charge":"No","author":[{"last_name":"Palero","first_name":"Ferran","id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0343-8329","full_name":"Palero, Ferran"},{"last_name":"Abello","first_name":"Pere","full_name":"Abello, Pere"},{"full_name":"Macpherson, Enrique","first_name":"Enrique","last_name":"Macpherson"},{"first_name":"Mark","last_name":"Beaumont","full_name":"Beaumont, Mark"},{"last_name":"Pascual","first_name":"Marta","full_name":"Pascual, Marta"}],"year":"2011","month":"05","type":"research_data_reference","publisher":"IST Austria","doi":"10.5061/dryad.299h8","_id":"9762","title":"Data from: Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster (Palinurus elephas)","abstract":[{"text":"Defining population structure and genetic diversity levels is of the utmost importance for developing efficient conservation strategies. Overfishing has caused mean annual catches of the European spiny lobster (Palinurus elephas) to decrease alarmingly along its distribution area. In this context, there is a need for comprehensive studies to evaluate the genetic health of the exploited populations. The present work is based on a set of 10 nuclear markers amplified in 331 individuals from 10 different localities covering most of P. elephas distribution area. Samples from Atlantic and Mediterranean basins showed small but significant differences, indicating that P. elephas populations do not behave as a single panmictic unit but form two partially-overlapping groups. Despite intense overfishing, our dataset did not recover a recent bottleneck signal, and showed a large and stable historical effective size instead. This result could be accounted for by specific life history traits (reproduction and longevity) and the limitations of molecular markers in covering very recent timescales for non temporal samples. Our study emphasizes the necessity of integrating information on effective population sizes and life history parameters when evaluating population connectivity levels from genetic data.","lang":"eng"}],"oa_version":"Published Version","department":[{"_id":"NiBa"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.299h8"}],"date_updated":"2025-09-30T08:42:31Z","related_material":{"record":[{"id":"3395","relation":"used_in_publication","status":"public"}]},"day":"12"},{"doi":"10.1534/genetics.111.129569","oa_version":"Submitted Version","_id":"3290","department":[{"_id":"NiBa"}],"external_id":{"isi":["000297020800022"]},"date_updated":"2025-09-30T09:21:06Z","date_created":"2018-12-11T12:02:29Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","date_published":"2011-11-01T00:00:00Z","issue":"3","year":"2011","type":"journal_article","publisher":"Genetics Society of America","ec_funded":1,"publication":"Genetics","abstract":[{"lang":"eng","text":"Analysis of genomic data requires an efficient way to calculate likelihoods across very large numbers of loci. We describe a general method for finding the distribution of genealogies: we allow migration between demes, splitting of demes [as in the isolation-with-migration (IM) model], and recombination between linked loci. These processes are described by a set of linear recursions for the generating function of branch lengths. Under the infinite-sites model, the probability of any configuration of mutations can be found by differentiating this generating function. Such calculations are feasible for small numbers of sampled genomes: as an example, we show how the generating function can be derived explicitly for three genes under the two-deme IM model. This derivation is done automatically, using Mathematica. Given data from a large number of unlinked and nonrecombining blocks of sequence, these results can be used to find maximum-likelihood estimates of model parameters by tabulating the probabilities of all relevant mutational configurations and then multiplying across loci. The feasibility of the method is demonstrated by applying it to simulated data and to a data set previously analyzed by Wang and Hey (2010) consisting of 26,141 loci sampled from Drosophila simulans and D. melanogaster. Our results suggest that such likelihood calculations are scalable to genomic data as long as the numbers of sampled individuals and mutations per sequence block are small."}],"intvolume":"       189","publication_status":"published","title":"A general method for calculating likelihoods under the coalescent process","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213358/"}],"day":"01","quality_controlled":"1","oa":1,"publist_id":"3355","author":[{"full_name":"Lohse, Konrad","last_name":"Lohse","first_name":"Konrad"},{"first_name":"Richard","last_name":"Harrison","full_name":"Harrison, Richard"},{"last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"page":"977 - 987","article_processing_charge":"No","citation":{"mla":"Lohse, Konrad, et al. “A General Method for Calculating Likelihoods under the Coalescent Process.” <i>Genetics</i>, vol. 189, no. 3, Genetics Society of America, 2011, pp. 977–87, doi:<a href=\"https://doi.org/10.1534/genetics.111.129569\">10.1534/genetics.111.129569</a>.","ieee":"K. Lohse, R. Harrison, and N. H. Barton, “A general method for calculating likelihoods under the coalescent process,” <i>Genetics</i>, vol. 189, no. 3. Genetics Society of America, pp. 977–987, 2011.","short":"K. Lohse, R. Harrison, N.H. Barton, Genetics 189 (2011) 977–987.","ista":"Lohse K, Harrison R, Barton NH. 2011. A general method for calculating likelihoods under the coalescent process. Genetics. 189(3), 977–987.","chicago":"Lohse, Konrad, Richard Harrison, and Nicholas H Barton. “A General Method for Calculating Likelihoods under the Coalescent Process.” <i>Genetics</i>. Genetics Society of America, 2011. <a href=\"https://doi.org/10.1534/genetics.111.129569\">https://doi.org/10.1534/genetics.111.129569</a>.","apa":"Lohse, K., Harrison, R., &#38; Barton, N. H. (2011). A general method for calculating likelihoods under the coalescent process. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.111.129569\">https://doi.org/10.1534/genetics.111.129569</a>","ama":"Lohse K, Harrison R, Barton NH. A general method for calculating likelihoods under the coalescent process. <i>Genetics</i>. 2011;189(3):977-987. doi:<a href=\"https://doi.org/10.1534/genetics.111.129569\">10.1534/genetics.111.129569</a>"},"isi":1,"volume":189,"scopus_import":"1","month":"11"},{"abstract":[{"lang":"eng","text":"Nowak et al.1 argue that inclusive fitness theory has been of little value in explaining the natural world, and that it has led to negligible progress in explaining the evolution of eusociality. However, we believe that their arguments are based upon a misunderstanding of evolutionary theory and a misrepresentation of the empirical literature. We will focus our comments on three general issues."}],"intvolume":"       471","publication":"Nature","title":"Inclusive fitness theory and eusociality","publication_status":"published","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836173/"}],"day":"23","quality_controlled":"1","publist_id":"3237","oa":1,"language":[{"iso":"eng"}],"author":[{"full_name":"Abbot, Patrick","first_name":"Patrick","last_name":"Abbot"},{"full_name":"Abe, Jun","last_name":"Abe","first_name":"Jun"},{"full_name":"Alcock, John","first_name":"John","last_name":"Alcock"},{"last_name":"Alizon","first_name":"Samuel","full_name":"Alizon, Samuel"},{"full_name":"Alpedrinha, Joao","first_name":"Joao","last_name":"Alpedrinha"},{"full_name":"Andersson, Malte","last_name":"Andersson","first_name":"Malte"},{"full_name":"Andre, Jean","last_name":"Andre","first_name":"Jean"},{"last_name":"Van Baalen","first_name":"Minus","full_name":"Van Baalen, Minus"},{"last_name":"Balloux","first_name":"Francois","full_name":"Balloux, Francois"},{"first_name":"Sigal","last_name":"Balshine","full_name":"Balshine, Sigal"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Beukeboom","first_name":"Leo","full_name":"Beukeboom, Leo"},{"first_name":"Jay","last_name":"Biernaskie","full_name":"Biernaskie, Jay"},{"first_name":"Trine","last_name":"Bilde","full_name":"Bilde, Trine"},{"full_name":"Borgia, Gerald","last_name":"Borgia","first_name":"Gerald"},{"last_name":"Breed","first_name":"Michael","full_name":"Breed, Michael"},{"first_name":"Sam","last_name":"Brown","full_name":"Brown, Sam"},{"full_name":"Bshary, Redouan","first_name":"Redouan","last_name":"Bshary"},{"first_name":"Angus","last_name":"Buckling","full_name":"Buckling, Angus"},{"full_name":"Burley, Nancy","first_name":"Nancy","last_name":"Burley"},{"full_name":"Burton Chellew, Max","first_name":"Max","last_name":"Burton Chellew"},{"last_name":"Cant","first_name":"Michael","full_name":"Cant, Michael"},{"full_name":"Chapuisat, Michel","last_name":"Chapuisat","first_name":"Michel"},{"full_name":"Charnov, Eric","first_name":"Eric","last_name":"Charnov"},{"first_name":"Tim","last_name":"Clutton Brock","full_name":"Clutton Brock, Tim"},{"first_name":"Andrew","last_name":"Cockburn","full_name":"Cockburn, Andrew"},{"first_name":"Blaine","last_name":"Cole","full_name":"Cole, Blaine"},{"last_name":"Colegrave","first_name":"Nick","full_name":"Colegrave, Nick"},{"full_name":"Cosmides, Leda","first_name":"Leda","last_name":"Cosmides"},{"last_name":"Couzin","first_name":"Iain","full_name":"Couzin, Iain"},{"full_name":"Coyne, Jerry","first_name":"Jerry","last_name":"Coyne"},{"last_name":"Creel","first_name":"Scott","full_name":"Creel, Scott"},{"full_name":"Crespi, Bernard","first_name":"Bernard","last_name":"Crespi"},{"full_name":"Curry, Robert","last_name":"Curry","first_name":"Robert"},{"full_name":"Dall, Sasha","last_name":"Dall","first_name":"Sasha"},{"first_name":"Troy","last_name":"Day","full_name":"Day, Troy"},{"first_name":"Janis","last_name":"Dickinson","full_name":"Dickinson, Janis"},{"first_name":"Lee","last_name":"Dugatkin","full_name":"Dugatkin, Lee"},{"full_name":"El Mouden, Claire","first_name":"Claire","last_name":"El Mouden"},{"first_name":"Stephen","last_name":"Emlen","full_name":"Emlen, Stephen"},{"first_name":"Jay","last_name":"Evans","full_name":"Evans, Jay"},{"first_name":"Regis","last_name":"Ferriere","full_name":"Ferriere, Regis"},{"first_name":"Jeremy","last_name":"Field","full_name":"Field, Jeremy"},{"full_name":"Foitzik, Susanne","last_name":"Foitzik","first_name":"Susanne"},{"first_name":"Kevin","last_name":"Foster","full_name":"Foster, Kevin"},{"first_name":"William","last_name":"Foster","full_name":"Foster, William"},{"first_name":"Charles","last_name":"Fox","full_name":"Fox, Charles"},{"last_name":"Gadau","first_name":"Juergen","full_name":"Gadau, Juergen"},{"first_name":"Sylvain","last_name":"Gandon","full_name":"Gandon, Sylvain"},{"last_name":"Gardner","first_name":"Andy","full_name":"Gardner, Andy"},{"last_name":"Gardner","first_name":"Michael","full_name":"Gardner, Michael"},{"first_name":"Thomas","last_name":"Getty","full_name":"Getty, Thomas"},{"full_name":"Goodisman, Michael","first_name":"Michael","last_name":"Goodisman"},{"last_name":"Grafen","first_name":"Alan","full_name":"Grafen, Alan"},{"full_name":"Grosberg, Rick","last_name":"Grosberg","first_name":"Rick"},{"first_name":"Christina","last_name":"Grozinger","full_name":"Grozinger, Christina"},{"last_name":"Gouyon","first_name":"Pierre","full_name":"Gouyon, Pierre"},{"full_name":"Gwynne, Darryl","last_name":"Gwynne","first_name":"Darryl"},{"last_name":"Harvey","first_name":"Paul","full_name":"Harvey, Paul"},{"full_name":"Hatchwell, Ben","last_name":"Hatchwell","first_name":"Ben"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"},{"first_name":"Heikki","last_name":"Helantera","full_name":"Helantera, Heikki"},{"first_name":"Ken","last_name":"Helms","full_name":"Helms, Ken"},{"full_name":"Hill, Kim","last_name":"Hill","first_name":"Kim"},{"full_name":"Jiricny, Natalie","last_name":"Jiricny","first_name":"Natalie"},{"full_name":"Johnstone, Rufus","last_name":"Johnstone","first_name":"Rufus"},{"last_name":"Kacelnik","first_name":"Alex","full_name":"Kacelnik, Alex"},{"full_name":"Kiers, E Toby","last_name":"Kiers","first_name":"E Toby"},{"full_name":"Kokko, Hanna","last_name":"Kokko","first_name":"Hanna"},{"first_name":"Jan","last_name":"Komdeur","full_name":"Komdeur, Jan"},{"full_name":"Korb, Judith","last_name":"Korb","first_name":"Judith"},{"first_name":"Daniel","last_name":"Kronauer","full_name":"Kronauer, Daniel"},{"full_name":"Kümmerli, Rolf","last_name":"Kümmerli","first_name":"Rolf"},{"full_name":"Lehmann, Laurent","last_name":"Lehmann","first_name":"Laurent"},{"full_name":"Linksvayer, Timothy","last_name":"Linksvayer","first_name":"Timothy"},{"last_name":"Lion","first_name":"Sébastien","full_name":"Lion, Sébastien"},{"full_name":"Lyon, Bruce","last_name":"Lyon","first_name":"Bruce"},{"full_name":"Marshall, James","last_name":"Marshall","first_name":"James"},{"full_name":"Mcelreath, Richard","last_name":"Mcelreath","first_name":"Richard"},{"full_name":"Michalakis, Yannis","first_name":"Yannis","last_name":"Michalakis"},{"last_name":"Michod","first_name":"Richard","full_name":"Michod, Richard"},{"first_name":"Douglas","last_name":"Mock","full_name":"Mock, Douglas"},{"full_name":"Monnin, Thibaud","first_name":"Thibaud","last_name":"Monnin"},{"first_name":"Robert","last_name":"Montgomerie","full_name":"Montgomerie, Robert"},{"full_name":"Moore, Allen","last_name":"Moore","first_name":"Allen"},{"full_name":"Mueller, Ulrich","last_name":"Mueller","first_name":"Ulrich"},{"full_name":"Noë, Ronald","first_name":"Ronald","last_name":"Noë"},{"full_name":"Okasha, Samir","last_name":"Okasha","first_name":"Samir"},{"full_name":"Pamilo, Pekka","last_name":"Pamilo","first_name":"Pekka"},{"full_name":"Parker, Geoff","last_name":"Parker","first_name":"Geoff"},{"last_name":"Pedersen","first_name":"Jes","full_name":"Pedersen, Jes"},{"first_name":"Ido","last_name":"Pen","full_name":"Pen, Ido"},{"last_name":"Pfennig","first_name":"David","full_name":"Pfennig, David"},{"first_name":"David","last_name":"Queller","full_name":"Queller, David"},{"full_name":"Rankin, Daniel","last_name":"Rankin","first_name":"Daniel"},{"first_name":"Sarah","last_name":"Reece","full_name":"Reece, Sarah"},{"full_name":"Reeve, Hudson","last_name":"Reeve","first_name":"Hudson"},{"first_name":"Max","last_name":"Reuter","full_name":"Reuter, Max"},{"first_name":"Gilbert","last_name":"Roberts","full_name":"Roberts, Gilbert"},{"first_name":"Simon","last_name":"Robson","full_name":"Robson, Simon"},{"last_name":"Roze","first_name":"Denis","full_name":"Roze, Denis"},{"full_name":"Rousset, Francois","first_name":"Francois","last_name":"Rousset"},{"last_name":"Rueppell","first_name":"Olav","full_name":"Rueppell, Olav"},{"last_name":"Sachs","first_name":"Joel","full_name":"Sachs, Joel"},{"full_name":"Santorelli, Lorenzo","first_name":"Lorenzo","last_name":"Santorelli"},{"first_name":"Paul","last_name":"Schmid Hempel","full_name":"Schmid Hempel, Paul"},{"full_name":"Schwarz, Michael","first_name":"Michael","last_name":"Schwarz"},{"last_name":"Scott Phillips","first_name":"Tom","full_name":"Scott Phillips, Tom"},{"full_name":"Shellmann Sherman, Janet","last_name":"Shellmann Sherman","first_name":"Janet"},{"first_name":"Paul","last_name":"Sherman","full_name":"Sherman, Paul"},{"full_name":"Shuker, David","first_name":"David","last_name":"Shuker"},{"last_name":"Smith","first_name":"Jeff","full_name":"Smith, Jeff"},{"full_name":"Spagna, Joseph","last_name":"Spagna","first_name":"Joseph"},{"first_name":"Beverly","last_name":"Strassmann","full_name":"Strassmann, Beverly"},{"full_name":"Suarez, Andrew","last_name":"Suarez","first_name":"Andrew"},{"first_name":"Liselotte","last_name":"Sundström","full_name":"Sundström, Liselotte"},{"first_name":"Michael","last_name":"Taborsky","full_name":"Taborsky, Michael"},{"full_name":"Taylor, Peter","first_name":"Peter","last_name":"Taylor"},{"full_name":"Thompson, Graham","last_name":"Thompson","first_name":"Graham"},{"full_name":"Tooby, John","last_name":"Tooby","first_name":"John"},{"last_name":"Tsutsui","first_name":"Neil","full_name":"Tsutsui, Neil"},{"full_name":"Tsuji, Kazuki","first_name":"Kazuki","last_name":"Tsuji"},{"full_name":"Turillazzi, Stefano","first_name":"Stefano","last_name":"Turillazzi"},{"full_name":"Úbeda, Francisco","last_name":"Úbeda","first_name":"Francisco"},{"full_name":"Vargo, Edward","first_name":"Edward","last_name":"Vargo"},{"first_name":"Bernard","last_name":"Voelkl","full_name":"Voelkl, Bernard"},{"full_name":"Wenseleers, Tom","last_name":"Wenseleers","first_name":"Tom"},{"full_name":"West, Stuart","last_name":"West","first_name":"Stuart"},{"last_name":"West Eberhard","first_name":"Mary","full_name":"West Eberhard, Mary"},{"full_name":"Westneat, David","last_name":"Westneat","first_name":"David"},{"full_name":"Wiernasz, Diane","last_name":"Wiernasz","first_name":"Diane"},{"full_name":"Wild, Geoff","last_name":"Wild","first_name":"Geoff"},{"first_name":"Richard","last_name":"Wrangham","full_name":"Wrangham, Richard"},{"full_name":"Young, Andrew","last_name":"Young","first_name":"Andrew"},{"first_name":"David","last_name":"Zeh","full_name":"Zeh, David"},{"full_name":"Zeh, Jeanne","last_name":"Zeh","first_name":"Jeanne"},{"full_name":"Zink, Andrew","last_name":"Zink","first_name":"Andrew"}],"citation":{"short":"P. Abbot, J. Abe, J. Alcock, S. Alizon, J. Alpedrinha, M. Andersson, J. Andre, M. Van Baalen, F. Balloux, S. Balshine, N.H. Barton, L. Beukeboom, J. Biernaskie, T. Bilde, G. Borgia, M. Breed, S. Brown, R. Bshary, A. Buckling, N. Burley, M. Burton Chellew, M. Cant, M. Chapuisat, E. Charnov, T. Clutton Brock, A. Cockburn, B. Cole, N. Colegrave, L. Cosmides, I. Couzin, J. Coyne, S. Creel, B. Crespi, R. Curry, S. Dall, T. Day, J. Dickinson, L. Dugatkin, C. El Mouden, S. Emlen, J. Evans, R. Ferriere, J. Field, S. Foitzik, K. Foster, W. Foster, C. Fox, J. Gadau, S. Gandon, A. Gardner, M. Gardner, T. Getty, M. Goodisman, A. Grafen, R. Grosberg, C. Grozinger, P. Gouyon, D. Gwynne, P. Harvey, B. Hatchwell, J. Heinze, H. Helantera, K. Helms, K. Hill, N. Jiricny, R. Johnstone, A. Kacelnik, E.T. Kiers, H. Kokko, J. Komdeur, J. Korb, D. Kronauer, R. Kümmerli, L. Lehmann, T. Linksvayer, S. Lion, B. Lyon, J. Marshall, R. Mcelreath, Y. Michalakis, R. Michod, D. Mock, T. Monnin, R. Montgomerie, A. Moore, U. Mueller, R. Noë, S. Okasha, P. Pamilo, G. Parker, J. Pedersen, I. Pen, D. Pfennig, D. Queller, D. Rankin, S. Reece, H. Reeve, M. Reuter, G. Roberts, S. Robson, D. Roze, F. Rousset, O. Rueppell, J. Sachs, L. Santorelli, P. Schmid Hempel, M. Schwarz, T. Scott Phillips, J. Shellmann Sherman, P. Sherman, D. Shuker, J. Smith, J. Spagna, B. Strassmann, A. Suarez, L. Sundström, M. Taborsky, P. Taylor, G. Thompson, J. Tooby, N. Tsutsui, K. Tsuji, S. Turillazzi, F. Úbeda, E. Vargo, B. Voelkl, T. Wenseleers, S. West, M. West Eberhard, D. Westneat, D. Wiernasz, G. Wild, R. Wrangham, A. Young, D. Zeh, J. Zeh, A. Zink, Nature 471 (2011) E1–E4.","ista":"Abbot P et al. 2011. Inclusive fitness theory and eusociality. Nature. 471(7339), E1–E4.","chicago":"Abbot, Patrick, Jun Abe, John Alcock, Samuel Alizon, Joao Alpedrinha, Malte Andersson, Jean Andre, et al. “Inclusive Fitness Theory and Eusociality.” <i>Nature</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/nature09831\">https://doi.org/10.1038/nature09831</a>.","ama":"Abbot P, Abe J, Alcock J, et al. Inclusive fitness theory and eusociality. <i>Nature</i>. 2011;471(7339):E1-E4. doi:<a href=\"https://doi.org/10.1038/nature09831\">10.1038/nature09831</a>","apa":"Abbot, P., Abe, J., Alcock, J., Alizon, S., Alpedrinha, J., Andersson, M., … Zink, A. (2011). Inclusive fitness theory and eusociality. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature09831\">https://doi.org/10.1038/nature09831</a>","mla":"Abbot, Patrick, et al. “Inclusive Fitness Theory and Eusociality.” <i>Nature</i>, vol. 471, no. 7339, Nature Publishing Group, 2011, pp. E1–4, doi:<a href=\"https://doi.org/10.1038/nature09831\">10.1038/nature09831</a>.","ieee":"P. Abbot <i>et al.</i>, “Inclusive fitness theory and eusociality,” <i>Nature</i>, vol. 471, no. 7339. Nature Publishing Group, pp. E1–E4, 2011."},"isi":1,"article_processing_charge":"No","page":"E1 - E4","scopus_import":"1","month":"03","volume":471,"doi":"10.1038/nature09831","oa_version":"Submitted Version","_id":"3372","department":[{"_id":"NiBa"}],"external_id":{"isi":["000288702200001"],"pmid":["21430721"]},"date_updated":"2025-09-30T08:58:00Z","date_created":"2018-12-11T12:02:57Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_published":"2011-03-23T00:00:00Z","status":"public","issue":"7339","pmid":1,"year":"2011","publisher":"Nature Publishing Group","type":"journal_article"},{"status":"public","date_published":"2011-05-01T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:02:58Z","article_type":"original","type":"journal_article","publisher":"The Royal Society","pmid":1,"issue":"58","year":"2011","oa_version":"Submitted Version","_id":"3375","doi":"10.1098/rsif.2010.0438","external_id":{"isi":["000289671700011"],"pmid":["21084341"]},"date_updated":"2025-09-30T08:55:17Z","department":[{"_id":"NiBa"}],"author":[{"last_name":"de Vladar","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5985-7653","full_name":"de Vladar, Harold"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"}],"language":[{"iso":"eng"}],"project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","grant_number":"250152"}],"page":"720 - 739","article_processing_charge":"No","isi":1,"citation":{"ieee":"H. de Vladar and N. H. Barton, “The statistical mechanics of a polygenic character under stabilizing selection mutation and drift,” <i>Journal of the Royal Society Interface</i>, vol. 8, no. 58. The Royal Society, pp. 720–739, 2011.","mla":"de Vladar, Harold, and Nicholas H. Barton. “The Statistical Mechanics of a Polygenic Character under Stabilizing Selection Mutation and Drift.” <i>Journal of the Royal Society Interface</i>, vol. 8, no. 58, The Royal Society, 2011, pp. 720–39, doi:<a href=\"https://doi.org/10.1098/rsif.2010.0438\">10.1098/rsif.2010.0438</a>.","short":"H. de Vladar, N.H. Barton, Journal of the Royal Society Interface 8 (2011) 720–739.","chicago":"Vladar, Harold de, and Nicholas H Barton. “The Statistical Mechanics of a Polygenic Character under Stabilizing Selection Mutation and Drift.” <i>Journal of the Royal Society Interface</i>. The Royal Society, 2011. <a href=\"https://doi.org/10.1098/rsif.2010.0438\">https://doi.org/10.1098/rsif.2010.0438</a>.","ista":"de Vladar H, Barton NH. 2011. The statistical mechanics of a polygenic character under stabilizing selection mutation and drift. Journal of the Royal Society Interface. 8(58), 720–739.","apa":"de Vladar, H., &#38; Barton, N. H. (2011). The statistical mechanics of a polygenic character under stabilizing selection mutation and drift. <i>Journal of the Royal Society Interface</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rsif.2010.0438\">https://doi.org/10.1098/rsif.2010.0438</a>","ama":"de Vladar H, Barton NH. The statistical mechanics of a polygenic character under stabilizing selection mutation and drift. <i>Journal of the Royal Society Interface</i>. 2011;8(58):720-739. doi:<a href=\"https://doi.org/10.1098/rsif.2010.0438\">10.1098/rsif.2010.0438</a>"},"oa":1,"publist_id":"3232","volume":8,"month":"05","scopus_import":"1","publication":"Journal of the Royal Society Interface","intvolume":"         8","abstract":[{"text":"By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation and genetic drift. This requires us to track only four macroscopic variables, instead of the distribution of all the allele frequencies that influence the trait. These macroscopic variables are the expectations of: the trait mean and its square, the genetic variance, and of a measure of heterozygosity, and are derived from a generating function that is in turn derived by maximizing an entropy measure. These four macroscopics are enough to accurately describe the dynamics of the trait mean and of its genetic variance (and in principle of any other quantity). Unlike previous approaches that were based on an infinite series of moments or cumulants, which had to be truncated arbitrarily, our calculations provide a well-defined approximation procedure. We apply the framework to abrupt and gradual changes in the optimum, as well as to changes in the strength of stabilizing selection. Our approximations are surprisingly accurate, even for systems with as few as five loci. We find that when the effects of drift are included, the expected genetic variance is hardly altered by directional selection, even though it fluctuates in any particular instance. We also find hysteresis, showing that even after averaging over the microscopic variables, the macroscopic trajectories retain a memory of the underlying genetic states.","lang":"eng"}],"title":"The statistical mechanics of a polygenic character under stabilizing selection mutation and drift","corr_author":"1","publication_status":"published","ec_funded":1,"day":"01","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061091/"}]},{"scopus_import":"1","month":"05","volume":93,"citation":{"ieee":"S. Logeswaran and N. H. Barton, “Mapping Mendelian traits in asexual progeny using changes in marker allele frequency,” <i>Genetical Research</i>, vol. 93, no. 3. Cambridge University Press, pp. 221–232, 2011.","mla":"Logeswaran, Sayanthan, and Nicholas H. Barton. “Mapping Mendelian Traits in Asexual Progeny Using Changes in Marker Allele Frequency.” <i>Genetical Research</i>, vol. 93, no. 3, Cambridge University Press, 2011, pp. 221–32, doi:<a href=\"https://doi.org/10.1017/S0016672311000115\">10.1017/S0016672311000115</a>.","ama":"Logeswaran S, Barton NH. Mapping Mendelian traits in asexual progeny using changes in marker allele frequency. <i>Genetical Research</i>. 2011;93(3):221-232. doi:<a href=\"https://doi.org/10.1017/S0016672311000115\">10.1017/S0016672311000115</a>","apa":"Logeswaran, S., &#38; Barton, N. H. (2011). Mapping Mendelian traits in asexual progeny using changes in marker allele frequency. <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672311000115\">https://doi.org/10.1017/S0016672311000115</a>","chicago":"Logeswaran, Sayanthan, and Nicholas H Barton. “Mapping Mendelian Traits in Asexual Progeny Using Changes in Marker Allele Frequency.” <i>Genetical Research</i>. Cambridge University Press, 2011. <a href=\"https://doi.org/10.1017/S0016672311000115\">https://doi.org/10.1017/S0016672311000115</a>.","ista":"Logeswaran S, Barton NH. 2011. Mapping Mendelian traits in asexual progeny using changes in marker allele frequency. Genetical Research. 93(3), 221–232.","short":"S. Logeswaran, N.H. Barton, Genetical Research 93 (2011) 221–232."},"article_processing_charge":"No","isi":1,"page":"221 - 232","language":[{"iso":"eng"}],"author":[{"full_name":"Logeswaran, Sayanthan","last_name":"Logeswaran","first_name":"Sayanthan"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"}],"publist_id":"3227","oa":1,"quality_controlled":"1","day":"18","main_file_link":[{"url":"https://www.pure.ed.ac.uk/ws/files/8144621/GR_2011_Barton.pdf","open_access":"1"}],"publication_status":"published","title":"Mapping Mendelian traits in asexual progeny using changes in marker allele frequency","intvolume":"        93","abstract":[{"text":"Linkage between markers and genes that affect a phenotype of interest may be determined by examining differences in marker allele frequency in the extreme progeny of a cross between two inbred lines. This strategy is usually employed when pooling is used to reduce genotyping costs. When the cross progeny are asexual, the extreme progeny may be selected by multiple generations of asexual reproduction and selection. We analyse this method of measuring phenotype in asexual progeny and examine the changes in marker allele frequency due to selection over many generations. Stochasticity in marker frequency in the selected population arises due to the finite initial population size. We derive the distribution of marker frequency as a result of selection at a single major locus, and show that in order to avoid spurious changes in marker allele frequency in the selected population, the initial population size should be in the low to mid hundreds.","lang":"eng"}],"publication":"Genetical Research","publisher":"Cambridge University Press","type":"journal_article","article_type":"original","year":"2011","issue":"3","ddc":["570"],"date_published":"2011-05-18T00:00:00Z","status":"public","date_created":"2018-12-11T12:03:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-06-18T18:45:27Z","external_id":{"isi":["000291114300005"]},"department":[{"_id":"NiBa"}],"_id":"3380","oa_version":"Published Version","doi":"10.1017/S0016672311000115"},{"date_updated":"2025-09-30T08:44:55Z","external_id":{"isi":["000293700000018"]},"department":[{"_id":"NiBa"}],"_id":"3390","oa_version":"Submitted Version","doi":"10.1534/genetics.111.127555","type":"journal_article","publisher":"Genetics Society of America","year":"2011","issue":"4","status":"public","date_published":"2011-08-01T00:00:00Z","date_created":"2018-12-11T12:03:04Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","quality_controlled":"1","day":"01","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176105/","open_access":"1"}],"publication_status":"published","title":"The relation between reproductive value and genetic contribution","corr_author":"1","publication":"Genetics","abstract":[{"text":"What determines the genetic contribution that an individual makes to future generations? With biparental reproduction, each individual leaves a 'pedigree' of descendants, determined by the biparental relationships in the population. The pedigree of an individual constrains the lines of descent of each of its genes. An individual's reproductive value is the expected number of copies of each of its genes that is passed on to distant generations conditional on its pedigree. For the simplest model of biparental reproduction analogous to the Wright-Fisher model, an individual's reproductive value is determined within ~10 generations, independent of population size. Partial selfing and subdivision do not greatly slow this convergence. Our central result is that the probability that a gene will survive is proportional to the reproductive value of the individual that carries it, and that conditional on survival, after a few tens of generations, the distribution of the number of surviving copies is the same for all individuals, whatever their reproductive value. These results can be generalized to the joint distribution of surviving blocks of ancestral genome. Selection on unlinked loci in the genetic background may greatly increase the variance in reproductive value, but the above results nevertheless still hold. The almost linear relationship between survival probability and reproductive value also holds for weakly favored alleles. Thus, the influence of the complex pedigree of descendants on an individual's genetic contribution to the population can be summarized through a single number: its reproductive value.","lang":"eng"}],"intvolume":"       188","ec_funded":1,"volume":188,"month":"08","scopus_import":"1","page":"953 - 973","citation":{"ista":"Barton NH, Etheridge A. 2011. The relation between reproductive value and genetic contribution. Genetics. 188(4), 953–973.","chicago":"Barton, Nicholas H, and Alison Etheridge. “The Relation between Reproductive Value and Genetic Contribution.” <i>Genetics</i>. Genetics Society of America, 2011. <a href=\"https://doi.org/10.1534/genetics.111.127555\">https://doi.org/10.1534/genetics.111.127555</a>.","apa":"Barton, N. H., &#38; Etheridge, A. (2011). The relation between reproductive value and genetic contribution. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.111.127555\">https://doi.org/10.1534/genetics.111.127555</a>","ama":"Barton NH, Etheridge A. The relation between reproductive value and genetic contribution. <i>Genetics</i>. 2011;188(4):953-973. doi:<a href=\"https://doi.org/10.1534/genetics.111.127555\">10.1534/genetics.111.127555</a>","short":"N.H. Barton, A. Etheridge, Genetics 188 (2011) 953–973.","ieee":"N. H. Barton and A. Etheridge, “The relation between reproductive value and genetic contribution,” <i>Genetics</i>, vol. 188, no. 4. Genetics Society of America, pp. 953–973, 2011.","mla":"Barton, Nicholas H., and Alison Etheridge. “The Relation between Reproductive Value and Genetic Contribution.” <i>Genetics</i>, vol. 188, no. 4, Genetics Society of America, 2011, pp. 953–73, doi:<a href=\"https://doi.org/10.1534/genetics.111.127555\">10.1534/genetics.111.127555</a>."},"isi":1,"article_processing_charge":"No","author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"},{"full_name":"Etheridge, Alison","first_name":"Alison","last_name":"Etheridge"}],"project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","grant_number":"250152"}],"language":[{"iso":"eng"}],"oa":1,"publist_id":"3217"},{"issue":"8","year":"2011","type":"journal_article","publisher":"Cell Press","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:03:04Z","status":"public","date_published":"2011-08-01T00:00:00Z","department":[{"_id":"NiBa"}],"external_id":{"arxiv":["1104.2854"],"isi":["000293940800010"]},"date_updated":"2025-09-30T08:44:25Z","doi":"10.1016/j.tree.2011.04.002","oa_version":"Submitted Version","_id":"3391","volume":26,"scopus_import":"1","month":"08","oa":1,"publist_id":"3216","arxiv":1,"author":[{"orcid":"0000-0002-5985-7653","full_name":"de Vladar, Harold","last_name":"de Vladar","first_name":"Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7"}],"page":"424 - 432","citation":{"mla":"de Vladar, Harold, and Nicholas H. Barton. “The Contribution of Statistical Physics to Evolutionary Biology.” <i>Trends in Ecology and Evolution</i>, vol. 26, no. 8, Cell Press, 2011, pp. 424–32, doi:<a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">10.1016/j.tree.2011.04.002</a>.","ieee":"H. de Vladar and N. H. Barton, “The contribution of statistical physics to evolutionary biology,” <i>Trends in Ecology and Evolution</i>, vol. 26, no. 8. Cell Press, pp. 424–432, 2011.","ama":"de Vladar H, Barton NH. The contribution of statistical physics to evolutionary biology. <i>Trends in Ecology and Evolution</i>. 2011;26(8):424-432. doi:<a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">10.1016/j.tree.2011.04.002</a>","apa":"de Vladar, H., &#38; Barton, N. H. (2011). The contribution of statistical physics to evolutionary biology. <i>Trends in Ecology and Evolution</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">https://doi.org/10.1016/j.tree.2011.04.002</a>","chicago":"Vladar, Harold de, and Nicholas H Barton. “The Contribution of Statistical Physics to Evolutionary Biology.” <i>Trends in Ecology and Evolution</i>. Cell Press, 2011. <a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">https://doi.org/10.1016/j.tree.2011.04.002</a>.","ista":"de Vladar H, Barton NH. 2011. The contribution of statistical physics to evolutionary biology. Trends in Ecology and Evolution. 26(8), 424–432.","short":"H. de Vladar, N.H. Barton, Trends in Ecology and Evolution 26 (2011) 424–432."},"article_processing_charge":"No","isi":1,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1104.2854"}],"day":"01","quality_controlled":"1","ec_funded":1,"publication":"Trends in Ecology and Evolution","abstract":[{"text":"Evolutionary biology shares many concepts with statistical physics: both deal with populations, whether of molecules or organisms, and both seek to simplify evolution in very many dimensions. Often, methodologies have undergone parallel and independent development, as with stochastic methods in population genetics. Here, we discuss aspects of population genetics that have embraced methods from physics: non-equilibrium statistical mechanics, travelling waves and Monte-Carlo methods, among others, have been used to study polygenic evolution, rates of adaptation and range expansions. These applications indicate that evolutionary biology can further benefit from interactions with other areas of statistical physics; for example, by following the distribution of paths taken by a population through time","lang":"eng"}],"intvolume":"        26","title":"The contribution of statistical physics to evolutionary biology","corr_author":"1","publication_status":"published"},{"author":[{"full_name":"Polechova, Jitka","orcid":"0000-0003-0951-3112","first_name":"Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","last_name":"Polechova"},{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"}],"language":[{"iso":"eng"}],"project":[{"grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"page":"227 - 235","citation":{"short":"J. Polechova, N.H. Barton, Genetics 189 (2011) 227–235.","chicago":"Polechova, Jitka, and Nicholas H Barton. “Genetic Drift Widens the Expected Cline but Narrows the Expected Cline Width.” <i>Genetics</i>. Genetics Society of America, 2011. <a href=\"https://doi.org/10.1534/genetics.111.129817\">https://doi.org/10.1534/genetics.111.129817</a>.","ista":"Polechova J, Barton NH. 2011. Genetic drift widens the expected cline but narrows the expected cline width. Genetics. 189(1), 227–235.","ama":"Polechova J, Barton NH. Genetic drift widens the expected cline but narrows the expected cline width. <i>Genetics</i>. 2011;189(1):227-235. doi:<a href=\"https://doi.org/10.1534/genetics.111.129817\">10.1534/genetics.111.129817</a>","apa":"Polechova, J., &#38; Barton, N. H. (2011). Genetic drift widens the expected cline but narrows the expected cline width. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.111.129817\">https://doi.org/10.1534/genetics.111.129817</a>","ieee":"J. Polechova and N. H. Barton, “Genetic drift widens the expected cline but narrows the expected cline width,” <i>Genetics</i>, vol. 189, no. 1. Genetics Society of America, pp. 227–235, 2011.","mla":"Polechova, Jitka, and Nicholas H. Barton. “Genetic Drift Widens the Expected Cline but Narrows the Expected Cline Width.” <i>Genetics</i>, vol. 189, no. 1, Genetics Society of America, 2011, pp. 227–35, doi:<a href=\"https://doi.org/10.1534/genetics.111.129817\">10.1534/genetics.111.129817</a>."},"article_processing_charge":"No","isi":1,"oa":1,"publist_id":"3213","volume":189,"month":"09","scopus_import":"1","publication":"Genetics","abstract":[{"lang":"eng","text":"Random genetic drift shifts clines in space, alters their width, and distorts their shape. Such random fluctuations complicate inferences from cline width and position. Notably, the effect of genetic drift on the expected shape of the cline is opposite to the naive (but quite common) misinterpretation of classic results on the expected cline. While random drift on average broadens the overall cline in expected allele frequency, it narrows the width of any particular cline. The opposing effects arise because locally, drift drives alleles to fixation—but fluctuations in position widen the expected cline. The effect of genetic drift can be predicted from standardized variance in allele frequencies, averaged across the habitat: 〈F〉. A cline maintained by spatially varying selection (step change) is expected to be narrower by a factor of  relative to the cline in the absence of drift. The expected cline is broader by the inverse of this factor. In a tension zone maintained by underdominance, the expected cline width is narrower by about 1 – 〈F〉relative to the width in the absence of drift. Individual clines can differ substantially from the expectation, and we give quantitative predictions for the variance in cline position and width. The predictions apply to clines in almost one-dimensional circumstances such as hybrid zones in rivers, deep valleys, or along a coast line and give a guide to what patterns to expect in two dimensions."}],"intvolume":"       189","publication_status":"published","corr_author":"1","title":"Genetic drift widens the expected cline but narrows the expected cline width","ec_funded":1,"day":"01","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176109/"}],"status":"public","date_published":"2011-09-01T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:03:05Z","type":"journal_article","publisher":"Genetics Society of America","issue":"1","year":"2011","oa_version":"Submitted Version","_id":"3394","doi":"10.1534/genetics.111.129817","external_id":{"isi":["000294721600018"]},"date_updated":"2025-09-30T08:42:59Z","department":[{"_id":"NiBa"}]},{"volume":104,"scopus_import":"1","month":"09","acknowledgement":"This work was supported by a pre-doctoral fellowship awarded by the Autonomous Government of Catalonia to F.P. (2006FIC-00082). Research was funded by projects FBBVA-BIOCON 08-187/09, CGL2006-13423, and CTM2007-66635. The authors are part of the research group 2009SGR-636, 2009SGR-655, and 2009SGR-1364 of the Generalitat de Catalunya. F.P. acknowledges EU-Synthesys grant (GB-TAF-4474).","publist_id":"3212","page":"407 - 418","isi":1,"article_processing_charge":"No","citation":{"ieee":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, and M. Pascual, “Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas,” <i>Biological Journal of the Linnean Society</i>, vol. 104, no. 2. Wiley-Blackwell, pp. 407–418, 2011.","mla":"Palero, Ferran, et al. “Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster Palinurus Elephas.” <i>Biological Journal of the Linnean Society</i>, vol. 104, no. 2, Wiley-Blackwell, 2011, pp. 407–18, doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">10.1111/j.1095-8312.2011.01728.x</a>.","short":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, M. Pascual, Biological Journal of the Linnean Society 104 (2011) 407–418.","ama":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. <i>Biological Journal of the Linnean Society</i>. 2011;104(2):407-418. doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">10.1111/j.1095-8312.2011.01728.x</a>","apa":"Palero, F., Abello, P., Macpherson, E., Beaumont, M., &#38; Pascual, M. (2011). Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>","ista":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. 2011. Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. Biological Journal of the Linnean Society. 104(2), 407–418.","chicago":"Palero, Ferran, Pere Abello, Enrique Macpherson, Mark Beaumont, and Marta Pascual. “Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster Palinurus Elephas.” <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell, 2011. <a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>."},"author":[{"orcid":"0000-0002-0343-8329","full_name":"Palero, Ferran","last_name":"Palero","id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87","first_name":"Ferran"},{"full_name":"Abello, Pere","last_name":"Abello","first_name":"Pere"},{"full_name":"Macpherson, Enrique","first_name":"Enrique","last_name":"Macpherson"},{"last_name":"Beaumont","first_name":"Mark","full_name":"Beaumont, Mark"},{"full_name":"Pascual, Marta","first_name":"Marta","last_name":"Pascual"}],"language":[{"iso":"eng"}],"quality_controlled":"1","day":"14","publication_status":"published","title":"Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas","corr_author":"1","publication":"Biological Journal of the Linnean Society","intvolume":"       104","abstract":[{"text":"Defining population structure and genetic diversity levels is of the utmost importance for developing efficient conservation strategies. Overfishing has caused mean annual catches of the European spiny lobster (Palinurus elephas) to decrease alarmingly along its distribution area. In this context, there is a need for comprehensive studies aiming to evaluate the genetic health of the exploited populations. The present study is based on a set of ten nuclear markers amplified in 331 individuals from ten different localities covering most of P. elephas distribution area. Samples from Atlantic and Mediterranean basins showed small but significant differences, indicating that P. elephas populations do not behave as a single panmictic unit but form two partially-overlapping groups. Despite intense overfishing, our dataset did not recover a recent bottleneck signal, and instead showed a large and stable historical effective size. This result could be accounted for by specific life-history traits (reproduction and longevity) and the limitations of molecular markers in covering recent timescales for nontemporal samples. The findings of the present study emphasize the need to integrate information on effective population sizes and life-history parameters when evaluating population connectivity levels from genetic data.","lang":"eng"}],"year":"2011","issue":"2","type":"journal_article","publisher":"Wiley-Blackwell","date_created":"2018-12-11T12:03:06Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","date_published":"2011-09-14T00:00:00Z","department":[{"_id":"NiBa"}],"date_updated":"2025-09-30T08:42:31Z","related_material":{"record":[{"relation":"research_data","id":"9762","status":"public"}]},"external_id":{"isi":["000294902700013"]},"doi":"10.1111/j.1095-8312.2011.01728.x","_id":"3395","oa_version":"None"},{"publist_id":"2449","oa":1,"language":[{"iso":"eng"}],"author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"}],"article_processing_charge":"No","isi":1,"citation":{"ama":"Barton NH. Estimating linkage disequilibria. <i>Heredity</i>. 2011;106(2):205-206. doi:<a href=\"https://doi.org/10.1038/hdy.2010.67\">10.1038/hdy.2010.67</a>","apa":"Barton, N. H. (2011). Estimating linkage disequilibria. <i>Heredity</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/hdy.2010.67\">https://doi.org/10.1038/hdy.2010.67</a>","ista":"Barton NH. 2011. Estimating linkage disequilibria. Heredity. 106(2), 205–206.","chicago":"Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/hdy.2010.67\">https://doi.org/10.1038/hdy.2010.67</a>.","short":"N.H. Barton, Heredity 106 (2011) 205–206.","ieee":"N. H. Barton, “Estimating linkage disequilibria,” <i>Heredity</i>, vol. 106, no. 2. Nature Publishing Group, pp. 205–206, 2011.","mla":"Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>, vol. 106, no. 2, Nature Publishing Group, 2011, pp. 205–06, doi:<a href=\"https://doi.org/10.1038/hdy.2010.67\">10.1038/hdy.2010.67</a>."},"page":"205 - 206","month":"02","scopus_import":"1","volume":106,"intvolume":"       106","publication":"Heredity","corr_author":"1","publication_status":"published","title":"Estimating linkage disequilibria","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183869/","open_access":"1"}],"day":"01","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:05:07Z","date_published":"2011-02-01T00:00:00Z","status":"public","pmid":1,"issue":"2","year":"2011","publisher":"Nature Publishing Group","type":"journal_article","doi":"10.1038/hdy.2010.67","oa_version":"Submitted Version","_id":"3778","department":[{"_id":"NiBa"}],"external_id":{"isi":["000286375300002"],"pmid":["20502479"]},"date_updated":"2025-09-30T08:38:46Z"},{"publication":"Journal of the Marine Biological Association of the United Kingdom","abstract":[{"text":"Advanced stages of Scyllarus phyllosoma larvae were collected by demersal trawling during fishery research surveys in the western Mediterranean Sea in 2003–2005. Nucleotide sequence analysis of the mitochondrial 16S rDNA gene allowed the final-stage phyllosoma of Scyllarus arctus to be identified among these larvae. Its morphology is described and illustrated. This constitutes the second complete description of a Scyllaridae phyllosoma with its specific identity being validated by molecular techniques (the first was S. pygmaeus). These results also solved a long lasting taxonomic anomaly of several species assigned to the ancient genus Phyllosoma Leach, 1814. Detailed examination indicated that the final-stage phyllosoma of S. arctus shows closer affinities with the American scyllarid Scyllarus depressus or with the Australian Scyllarus sp. b (sensu Phillips et al., 1981) than to its sympatric species S. pygmaeus.","lang":"eng"}],"intvolume":"        91","publication_status":"published","title":"Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description","corr_author":"1","main_file_link":[{"url":"https://digital.csic.es/bitstream/10261/32783/3/Palero_et_al_2011.pdf","open_access":"1"}],"day":"01","quality_controlled":"1","oa":1,"publist_id":"2443","author":[{"full_name":"Palero, Ferran","orcid":"0000-0002-0343-8329","first_name":"Ferran","id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87","last_name":"Palero"},{"first_name":"Guillermo","last_name":"Guerao","full_name":"Guerao, Guillermo"},{"last_name":"Clark","first_name":"Paul","full_name":"Clark, Paul"},{"full_name":"Abello, Pere","last_name":"Abello","first_name":"Pere"}],"language":[{"iso":"eng"}],"page":"485 - 492","citation":{"short":"F. Palero, G. Guerao, P. Clark, P. Abello, Journal of the Marine Biological Association of the United Kingdom 91 (2011) 485–492.","chicago":"Palero, Ferran, Guillermo Guerao, Paul Clark, and Pere Abello. “Scyllarus Arctus (Crustacea: Decapoda: Scyllaridae) Final Stage Phyllosoma Identified by DNA Analysis, with Morphological Description.” <i>Journal of the Marine Biological Association of the United Kingdom</i>. Cambridge University Press, 2011. <a href=\"https://doi.org/10.1017/S0025315410000287\">https://doi.org/10.1017/S0025315410000287</a>.","ista":"Palero F, Guerao G, Clark P, Abello P. 2011. Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. Journal of the Marine Biological Association of the United Kingdom. 91(2), 485–492.","apa":"Palero, F., Guerao, G., Clark, P., &#38; Abello, P. (2011). Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. <i>Journal of the Marine Biological Association of the United Kingdom</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0025315410000287\">https://doi.org/10.1017/S0025315410000287</a>","ama":"Palero F, Guerao G, Clark P, Abello P. Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. <i>Journal of the Marine Biological Association of the United Kingdom</i>. 2011;91(2):485-492. doi:<a href=\"https://doi.org/10.1017/S0025315410000287\">10.1017/S0025315410000287</a>","mla":"Palero, Ferran, et al. “Scyllarus Arctus (Crustacea: Decapoda: Scyllaridae) Final Stage Phyllosoma Identified by DNA Analysis, with Morphological Description.” <i>Journal of the Marine Biological Association of the United Kingdom</i>, vol. 91, no. 2, Cambridge University Press, 2011, pp. 485–92, doi:<a href=\"https://doi.org/10.1017/S0025315410000287\">10.1017/S0025315410000287</a>.","ieee":"F. Palero, G. Guerao, P. Clark, and P. Abello, “Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description,” <i>Journal of the Marine Biological Association of the United Kingdom</i>, vol. 91, no. 2. Cambridge University Press, pp. 485–492, 2011."},"isi":1,"article_processing_charge":"No","volume":91,"month":"03","scopus_import":"1","doi":"10.1017/S0025315410000287","oa_version":"Published Version","_id":"3784","department":[{"_id":"NiBa"}],"external_id":{"isi":["000287940400022"]},"date_updated":"2026-06-18T18:46:40Z","date_created":"2018-12-11T12:05:09Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2011-03-01T00:00:00Z","ddc":["570"],"issue":"2","year":"2011","article_type":"original","type":"journal_article","publisher":"Cambridge University Press"},{"volume":178,"scopus_import":"1","month":"09","publication_identifier":{"issn":["0003-0147"],"eissn":["1537-5323"]},"oa":1,"publist_id":"3214","page":"E48 - E75","isi":1,"citation":{"apa":"Barton, N. H., &#38; Turelli, M. (2011). Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. <i>American Naturalist</i>. University of Chicago Press. <a href=\"https://doi.org/10.1086/661246\">https://doi.org/10.1086/661246</a>","ama":"Barton NH, Turelli M. Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. <i>American Naturalist</i>. 2011;178(3):E48-E75. doi:<a href=\"https://doi.org/10.1086/661246\">10.1086/661246</a>","chicago":"Barton, Nicholas H, and Michael Turelli. “Spatial Waves of Advance with Bistable Dynamics: Cytoplasmic and Genetic Analogues of Allee Effects.” <i>American Naturalist</i>. University of Chicago Press, 2011. <a href=\"https://doi.org/10.1086/661246\">https://doi.org/10.1086/661246</a>.","ista":"Barton NH, Turelli M. 2011. Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. American Naturalist. 178(3), E48–E75.","short":"N.H. Barton, M. Turelli, American Naturalist 178 (2011) E48–E75.","ieee":"N. H. Barton and M. Turelli, “Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects,” <i>American Naturalist</i>, vol. 178, no. 3. University of Chicago Press, pp. E48–E75, 2011.","mla":"Barton, Nicholas H., and Michael Turelli. “Spatial Waves of Advance with Bistable Dynamics: Cytoplasmic and Genetic Analogues of Allee Effects.” <i>American Naturalist</i>, vol. 178, no. 3, University of Chicago Press, 2011, pp. E48–75, doi:<a href=\"https://doi.org/10.1086/661246\">10.1086/661246</a>."},"article_processing_charge":"No","author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton"},{"full_name":"Turelli, Michael","last_name":"Turelli","first_name":"Michael"}],"language":[{"iso":"eng"}],"quality_controlled":"1","day":"01","has_accepted_license":"1","title":"Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects","publication_status":"published","publication":"American Naturalist","abstract":[{"lang":"eng","text":"Unlike unconditionally advantageous “Fisherian” variants that tend to spread throughout a species range once introduced anywhere, “bistable” variants, such as chromosome translocations, have two alternative stable frequencies, absence and (near) fixation. Analogous to populations with Allee effects, bistable variants tend to increase locally only once they become sufficiently common, and their spread depends on their rate of increase averaged over all frequencies. Several proposed manipulations of insect populations, such as using Wolbachia or “engineered underdominance” to suppress vector-borne diseases, produce bistable rather than Fisherian dynamics. We synthesize and extend theoretical analyses concerning three features of their spatial behavior: rate of spread, conditions to initiate spread from a localized introduction, and wave stopping caused by variation in population densities or dispersal rates. Unlike Fisherian variants, bistable variants tend to spread spatially only for particular parameter combinations and initial conditions. Wave initiation requires introduction over an extended region, while subsequent spatial spread is slower than for Fisherian waves and can easily be halted by local spatial inhomogeneities. We present several new results, including robust sufficient conditions to initiate (and stop) spread, using a one-parameter cubic approximation applicable to several models. The results have both basic and applied implications."}],"intvolume":"       178","year":"2011","ddc":["570"],"issue":"3","type":"journal_article","article_type":"original","publisher":"University of Chicago Press","date_created":"2018-12-11T12:03:05Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","pubrep_id":"554","date_published":"2011-09-01T00:00:00Z","department":[{"_id":"NiBa"}],"date_updated":"2026-08-04T09:17:38Z","external_id":{"isi":["000294256800001"]},"doi":"10.1086/661246","_id":"3393","file":[{"creator":"system","file_size":629130,"file_name":"IST-2016-554-v1+1_BartonTurelli2011_copy.pdf","file_id":"4692","checksum":"7fd22a2ef3321a6fca6a439b3be5d8f4","access_level":"open_access","date_updated":"2020-07-14T12:46:11Z","date_created":"2018-12-12T10:08:31Z","content_type":"application/pdf","relation":"main_file"}],"file_date_updated":"2020-07-14T12:46:11Z","oa_version":"Submitted Version"},{"abstract":[{"text":"Classical models of gene flow fail in three ways: they cannot explain large-scale patterns; they predict much more genetic diversity than is observed; and they assume that loosely linked genetic loci evolve independently. We propose a new model that deals with these problems. Extinction events kill some fraction of individuals in a region. These are replaced by offspring from a small number of parents, drawn from the preexisting population. This model of evolution forwards in time corresponds to a backwards model, in which ancestral lineages jump to a new location if they are hit by an event, and may coalesce with other lineages that are hit by the same event. We derive an expression for the identity in allelic state, and show that, over scales much larger than the largest event, this converges to the classical value derived by Wright and Malécot. However, rare events that cover large areas cause low genetic diversity, large-scale patterns, and correlations in ancestry between unlinked loci.","lang":"eng"}],"intvolume":"        64","publication":"Evolution","title":"A new model for extinction and recolonization in two dimensions: Quantifying phylogeography","publication_status":"published","corr_author":"1","day":"01","quality_controlled":"1","publist_id":"2780","acknowledgement":"This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF). The ECDF is partially supported by the eDIKT initiative. NHB is supported in part by EPSRC Grant EP/E066070/1; JK is supported by EPSRC Grant EP/E066070/1; and AME is supported in part by EPSRC Grant EP/E065945/1.","language":[{"iso":"eng"}],"author":[{"first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240"},{"full_name":"Kelleher, Jerome","last_name":"Kelleher","first_name":"Jerome"},{"first_name":"Alison","last_name":"Etheridge","full_name":"Etheridge, Alison"}],"isi":1,"citation":{"short":"N.H. Barton, J. Kelleher, A. Etheridge, Evolution 64 (2010) 2701–2715.","apa":"Barton, N. H., Kelleher, J., &#38; Etheridge, A. (2010). A new model for extinction and recolonization in two dimensions: Quantifying phylogeography. <i>Evolution</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1558-5646.2010.01019.x\">https://doi.org/10.1111/j.1558-5646.2010.01019.x</a>","ama":"Barton NH, Kelleher J, Etheridge A. A new model for extinction and recolonization in two dimensions: Quantifying phylogeography. <i>Evolution</i>. 2010;64(9):2701-2715. doi:<a href=\"https://doi.org/10.1111/j.1558-5646.2010.01019.x\">10.1111/j.1558-5646.2010.01019.x</a>","chicago":"Barton, Nicholas H, Jerome Kelleher, and Alison Etheridge. “A New Model for Extinction and Recolonization in Two Dimensions: Quantifying Phylogeography.” <i>Evolution</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1111/j.1558-5646.2010.01019.x\">https://doi.org/10.1111/j.1558-5646.2010.01019.x</a>.","ista":"Barton NH, Kelleher J, Etheridge A. 2010. A new model for extinction and recolonization in two dimensions: Quantifying phylogeography. Evolution. 64(9), 2701–2715.","mla":"Barton, Nicholas H., et al. “A New Model for Extinction and Recolonization in Two Dimensions: Quantifying Phylogeography.” <i>Evolution</i>, vol. 64, no. 9, Wiley-Blackwell, 2010, pp. 2701–15, doi:<a href=\"https://doi.org/10.1111/j.1558-5646.2010.01019.x\">10.1111/j.1558-5646.2010.01019.x</a>.","ieee":"N. H. Barton, J. Kelleher, and A. Etheridge, “A new model for extinction and recolonization in two dimensions: Quantifying phylogeography,” <i>Evolution</i>, vol. 64, no. 9. Wiley-Blackwell, pp. 2701–2715, 2010."},"article_processing_charge":"No","page":"2701 - 2715","scopus_import":"1","month":"09","volume":64,"doi":"10.1111/j.1558-5646.2010.01019.x","oa_version":"None","_id":"474","department":[{"_id":"NiBa"}],"external_id":{"isi":["000281636400017"]},"date_updated":"2025-09-30T09:50:22Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T11:46:40Z","date_published":"2010-09-01T00:00:00Z","status":"public","issue":"9","year":"2010","publisher":"Wiley-Blackwell","type":"journal_article"},{"date_created":"2021-08-02T09:45:39Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","author":[{"last_name":"Rosas","first_name":"Ulises","full_name":"Rosas, Ulises"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lucy","last_name":"Copsey","full_name":"Copsey, Lucy"},{"full_name":"Barbier De Reuille, Pierre","first_name":"Pierre","last_name":"Barbier De Reuille"},{"first_name":"Enrico","last_name":"Coen","full_name":"Coen, Enrico"}],"status":"public","citation":{"apa":"Rosas, U., Barton, N. H., Copsey, L., Barbier De Reuille, P., &#38; Coen, E. (2010). Heterosis and the drift load. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.1000429.s003\">https://doi.org/10.1371/journal.pbio.1000429.s003</a>","ama":"Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. Heterosis and the drift load. 2010. doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000429.s003\">10.1371/journal.pbio.1000429.s003</a>","ista":"Rosas U, Barton NH, Copsey L, Barbier De Reuille P, Coen E. 2010. Heterosis and the drift load, Public Library of Science, <a href=\"https://doi.org/10.1371/journal.pbio.1000429.s003\">10.1371/journal.pbio.1000429.s003</a>.","chicago":"Rosas, Ulises, Nicholas H Barton, Lucy Copsey, Pierre Barbier De Reuille, and Enrico Coen. “Heterosis and the Drift Load.” Public Library of Science, 2010. <a href=\"https://doi.org/10.1371/journal.pbio.1000429.s003\">https://doi.org/10.1371/journal.pbio.1000429.s003</a>.","short":"U. Rosas, N.H. Barton, L. Copsey, P. Barbier De Reuille, E. Coen, (2010).","ieee":"U. Rosas, N. H. Barton, L. Copsey, P. Barbier De Reuille, and E. Coen, “Heterosis and the drift load.” Public Library of Science, 2010.","mla":"Rosas, Ulises, et al. <i>Heterosis and the Drift Load</i>. Public Library of Science, 2010, doi:<a href=\"https://doi.org/10.1371/journal.pbio.1000429.s003\">10.1371/journal.pbio.1000429.s003</a>."},"article_processing_charge":"No","date_published":"2010-07-20T00:00:00Z","year":"2010","month":"07","type":"research_data_reference","publisher":"Public Library of Science","doi":"10.1371/journal.pbio.1000429.s003","oa_version":"Published Version","_id":"9764","title":"Heterosis and the drift load","department":[{"_id":"NiBa"}],"day":"20","date_updated":"2025-09-30T09:42:52Z","related_material":{"record":[{"relation":"used_in_publication","id":"3779","status":"public"}]}}]