---
_id: '8254'
abstract:
- lang: eng
text: "Here are the research data underlying the publication \"Estimating inbreeding
and its effects in a long-term study of snapdragons (Antirrhinum majus)\". Further
information are summed up in the README document.\r\nThe files for this record
have been updated and are now found in the linked DOI https://doi.org/10.15479/AT:ISTA:9192."
article_processing_charge: No
author:
- first_name: Louise S
full_name: Arathoon, Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
orcid: 0000-0003-1771-714X
citation:
ama: Arathoon LS. Estimating inbreeding and its effects in a long-term study of
snapdragons (Antirrhinum majus). 2020. doi:10.15479/AT:ISTA:8254
apa: Arathoon, L. S. (2020). Estimating inbreeding and its effects in a long-term
study of snapdragons (Antirrhinum majus). Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8254
chicago: Arathoon, Louise S. “Estimating Inbreeding and Its Effects in a Long-Term
Study of Snapdragons (Antirrhinum Majus).” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8254.
ieee: L. S. Arathoon, “Estimating inbreeding and its effects in a long-term study
of snapdragons (Antirrhinum majus).” Institute of Science and Technology Austria,
2020.
ista: Arathoon LS. 2020. Estimating inbreeding and its effects in a long-term study
of snapdragons (Antirrhinum majus), Institute of Science and Technology Austria,
10.15479/AT:ISTA:8254.
mla: Arathoon, Louise S. Estimating Inbreeding and Its Effects in a Long-Term
Study of Snapdragons (Antirrhinum Majus). Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:8254.
short: L.S. Arathoon, (2020).
contributor:
- contributor_type: data_collector
first_name: Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
- contributor_type: project_member
first_name: Parvathy
id: 455235B8-F248-11E8-B48F-1D18A9856A87
last_name: Surendranadh
- contributor_type: project_member
first_name: Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- contributor_type: project_member
first_name: David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- contributor_type: project_member
first_name: Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- contributor_type: project_member
first_name: Carina
id: 3B4A7CE2-F248-11E8-B48F-1D18A9856A87
last_name: Baskett
corr_author: '1'
date_created: 2020-08-12T12:49:23Z
date_published: 2020-08-18T00:00:00Z
date_updated: 2024-10-09T21:02:14Z
day: '18'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:8254
file:
- access_level: open_access
checksum: 4f1382ed4384751b6013398c11557bf6
content_type: application/x-zip-compressed
creator: dernst
date_created: 2020-08-18T08:03:23Z
date_updated: 2020-08-18T08:03:23Z
file_id: '8280'
file_name: Data_Rcode_MathematicaNB.zip
file_size: 5778420
relation: main_file
success: 1
file_date_updated: 2020-08-18T08:03:23Z
has_accepted_license: '1'
month: '08'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9192'
relation: later_version
status: public
- id: '11321'
relation: later_version
status: public
status: public
title: Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum
majus)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
OA_place: publisher
_id: '8574'
abstract:
- lang: eng
text: "This thesis concerns itself with the interactions of evolutionary and ecological
forces and the consequences on genetic diversity and the ultimate survival of
populations. It is important to understand what signals processes \r\nleave on
the genome and what we can infer from such data, which is usually abundant but
noisy. Furthermore, understanding how and when populations adapt or go extinct
is important for practical purposes, such as the genetic management of populations,
as well as for theoretical questions, since local adaptation can be the first
step toward speciation. \r\nIn Chapter 2, we introduce the method of maximum entropy
to approximate the demographic changes of a population in a simple setting, namely
the logistic growth model with immigration. We show that this method is not only
a powerful \r\ntool in physics but can be gainfully applied in an ecological framework.
We investigate how well it approximates the real \r\nbehavior of the system, and
find that is does so, even in unexpected situations. Finally, we illustrate how
it can model changing environments.\r\nIn Chapter 3, we analyze the co-evolution
of allele frequencies and population sizes in an infinite island model.\r\nWe
give conditions under which polygenic adaptation to a rare habitat is possible.
The model we use is based on the diffusion approximation, considers eco-evolutionary
feedback mechanisms (hard selection), and treats both \r\ndrift and environmental
fluctuations explicitly. We also look at limiting scenarios, for which we derive
analytical expressions. \r\nIn Chapter 4, we present a coalescent based simulation
tool to obtain patterns of diversity in a spatially explicit subdivided population,
in which the demographic history of each subpopulation can be specified. We compare
\r\nthe results to existing predictions, and explore the relative importance of
time and space under a variety of spatial arrangements and demographic histories,
such as expansion and extinction. \r\nIn the last chapter, we give a brief outlook
to further research. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Eniko
full_name: Szep, Eniko
id: 485BB5A4-F248-11E8-B48F-1D18A9856A87
last_name: Szep
citation:
ama: Szep E. Local adaptation in metapopulations. 2020. doi:10.15479/AT:ISTA:8574
apa: Szep, E. (2020). Local adaptation in metapopulations. Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:8574
chicago: Szep, Eniko. “Local Adaptation in Metapopulations.” Institute of Science
and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8574.
ieee: E. Szep, “Local adaptation in metapopulations,” Institute of Science and Technology
Austria, 2020.
ista: Szep E. 2020. Local adaptation in metapopulations. Institute of Science and
Technology Austria.
mla: Szep, Eniko. Local Adaptation in Metapopulations. Institute of Science
and Technology Austria, 2020, doi:10.15479/AT:ISTA:8574.
short: E. Szep, Local Adaptation in Metapopulations, Institute of Science and Technology
Austria, 2020.
corr_author: '1'
date_created: 2020-09-28T07:33:38Z
date_published: 2020-09-20T00:00:00Z
date_updated: 2026-04-08T07:21:44Z
day: '20'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:8574
file:
- access_level: open_access
checksum: 20e71f015fbbd78fea708893ad634ed0
content_type: application/pdf
creator: dernst
date_created: 2020-09-28T07:25:35Z
date_updated: 2020-09-28T07:25:35Z
file_id: '8575'
file_name: thesis_EnikoSzep_final.pdf
file_size: 6354833
relation: main_file
success: 1
- access_level: closed
checksum: a8de2c14a1bb4e53c857787efbb289e1
content_type: application/x-zip-compressed
creator: dernst
date_created: 2020-09-28T07:25:37Z
date_updated: 2020-09-28T07:25:37Z
file_id: '8576'
file_name: thesisFiles_EnikoSzep.zip
file_size: 23020401
relation: source_file
file_date_updated: 2020-09-28T07:25:37Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '158'
publication_identifier:
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Local adaptation in metapopulations
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
_id: '8809'
abstract:
- lang: eng
text: When divergent populations are connected by gene flow, the establishment of
complete reproductive isolation usually requires the joint action of multiple
barrier effects. One example where multiple barrier effects are coupled consists
of a single trait that is under divergent natural selection and also mediates
assortative mating. Such multiple-effect traits can strongly reduce gene flow.
However, there are few cases where patterns of assortative mating have been described
quantitatively and their impact on gene flow has been determined. Two ecotypes
of the coastal marine snail, Littorina saxatilis, occur in North Atlantic rocky-shore
habitats dominated by either crab predation or wave action. There is evidence
for divergent natural selection acting on size, and size-assortative mating has
previously been documented. Here, we analyze the mating pattern in L. saxatilis
with respect to size in intensively-sampled transects across boundaries between
the habitats. We show that the mating pattern is mostly conserved between ecotypes
and that it generates both assortment and directional sexual selection for small
male size. Using simulations, we show that the mating pattern can contribute to
reproductive isolation between ecotypes but the barrier to gene flow is likely
strengthened more by sexual selection than by assortment.
article_processing_charge: No
author:
- first_name: Samuel
full_name: Perini, Samuel
last_name: Perini
- first_name: Marina
full_name: Rafajlovic, Marina
last_name: Rafajlovic
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. Data from: Assortative
mating, sexual selection and their consequences for gene flow in Littorina. 2020.
doi:10.5061/dryad.qrfj6q5cn'
apa: 'Perini, S., Rafajlovic, M., Westram, A. M., Johannesson, K., & Butlin,
R. (2020). Data from: Assortative mating, sexual selection and their consequences
for gene flow in Littorina. Dryad. https://doi.org/10.5061/dryad.qrfj6q5cn'
chicago: 'Perini, Samuel, Marina Rafajlovic, Anja M Westram, Kerstin Johannesson,
and Roger Butlin. “Data from: Assortative Mating, Sexual Selection and Their Consequences
for Gene Flow in Littorina.” Dryad, 2020. https://doi.org/10.5061/dryad.qrfj6q5cn.'
ieee: 'S. Perini, M. Rafajlovic, A. M. Westram, K. Johannesson, and R. Butlin, “Data
from: Assortative mating, sexual selection and their consequences for gene flow
in Littorina.” Dryad, 2020.'
ista: 'Perini S, Rafajlovic M, Westram AM, Johannesson K, Butlin R. 2020. Data from:
Assortative mating, sexual selection and their consequences for gene flow in Littorina,
Dryad, 10.5061/dryad.qrfj6q5cn.'
mla: 'Perini, Samuel, et al. Data from: Assortative Mating, Sexual Selection
and Their Consequences for Gene Flow in Littorina. Dryad, 2020, doi:10.5061/dryad.qrfj6q5cn.'
short: S. Perini, M. Rafajlovic, A.M. Westram, K. Johannesson, R. Butlin, (2020).
date_created: 2020-11-25T11:07:25Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2025-07-10T11:54:59Z
day: '01'
department:
- _id: NiBa
doi: 10.5061/dryad.qrfj6q5cn
has_accepted_license: '1'
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.qrfj6q5cn
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '7995'
relation: used_in_publication
status: public
status: public
title: 'Data from: Assortative mating, sexual selection and their consequences for
gene flow in Littorina'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2020'
...
---
_id: '9123'
abstract:
- lang: eng
text: 'Inversions are chromosomal rearrangements where the order of genes is reversed.
Inversions originate by mutation and can be under positive, negative or balancing
selection. Selective effects result from potential disruptive effects on meiosis,
gene disruption at inversion breakpoints and, importantly, the effects of inversions
as modifiers of recombination rate: Recombination is strongly reduced in individuals
heterozygous for an inversion, allowing for alleles at different loci to be inherited
as a ‘block’. This may lead to a selective advantage whenever it is favourable
to keep certain combinations of alleles associated, for example under local adaptation
with gene flow. Inversions can cover a considerable part of a chromosome and contain
numerous loci under different selection pressures, so that the resulting overall
effects may be complex. Empirical data from various systems show that inversions
may have a prominent role in local adaptation, speciation, parallel evolution,
the maintenance of polymorphism and sex chromosome evolution.'
article_processing_charge: No
author:
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
citation:
ama: 'Westram AM, Faria R, Butlin R, Johannesson K. Inversions and Evolution. In:
ELS. Wiley; 2020. doi:10.1002/9780470015902.a0029007'
apa: Westram, A. M., Faria, R., Butlin, R., & Johannesson, K. (2020). Inversions
and Evolution. In eLS. Wiley. https://doi.org/10.1002/9780470015902.a0029007
chicago: Westram, Anja M, Rui Faria, Roger Butlin, and Kerstin Johannesson. “Inversions
and Evolution.” In ELS. Wiley, 2020. https://doi.org/10.1002/9780470015902.a0029007.
ieee: A. M. Westram, R. Faria, R. Butlin, and K. Johannesson, “Inversions and Evolution,”
in eLS, Wiley, 2020.
ista: 'Westram AM, Faria R, Butlin R, Johannesson K. 2020.Inversions and Evolution.
In: eLS. .'
mla: Westram, Anja M., et al. “Inversions and Evolution.” ELS, Wiley, 2020,
doi:10.1002/9780470015902.a0029007.
short: A.M. Westram, R. Faria, R. Butlin, K. Johannesson, in:, ELS, Wiley, 2020.
date_created: 2021-02-15T12:39:04Z
date_published: 2020-05-16T00:00:00Z
date_updated: 2026-04-16T10:25:26Z
day: '16'
department:
- _id: NiBa
doi: 10.1002/9780470015902.a0029007
language:
- iso: eng
month: '05'
oa_version: None
publication: eLS
publication_identifier:
eissn:
- '9780470015902'
isbn:
- '9780470016176'
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Inversions and Evolution
type: book_chapter
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '9798'
abstract:
- lang: eng
text: Fitness interactions between mutations can influence a population’s evolution
in many different ways. While epistatic effects are difficult to measure precisely,
important information is captured by the mean and variance of log fitnesses for
individuals carrying different numbers of mutations. We derive predictions for
these quantities from a class of simple fitness landscapes, based on models of
optimizing selection on quantitative traits. We also explore extensions to the
models, including modular pleiotropy, variable effect sizes, mutational bias and
maladaptation of the wild type. We illustrate our approach by reanalysing a large
dataset of mutant effects in a yeast snoRNA. Though characterized by some large
epistatic effects, these data give a good overall fit to the non-epistatic null
model, suggesting that epistasis might have limited influence on the evolutionary
dynamics in this system. We also show how the amount of epistasis depends on both
the underlying fitness landscape and the distribution of mutations, and so is
expected to vary in consistent ways between new mutations, standing variation
and fixed mutations.
article_processing_charge: No
author:
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: John J.
full_name: Welch, John J.
last_name: Welch
citation:
ama: Fraisse C, Welch JJ. Simulation code for Fig S2 from the distribution of epistasis
on simple fitness landscapes. 2020. doi:10.6084/m9.figshare.7957472.v1
apa: Fraisse, C., & Welch, J. J. (2020). Simulation code for Fig S2 from the
distribution of epistasis on simple fitness landscapes. Royal Society of London.
https://doi.org/10.6084/m9.figshare.7957472.v1
chicago: Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S2 from
the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of
London, 2020. https://doi.org/10.6084/m9.figshare.7957472.v1.
ieee: C. Fraisse and J. J. Welch, “Simulation code for Fig S2 from the distribution
of epistasis on simple fitness landscapes.” Royal Society of London, 2020.
ista: Fraisse C, Welch JJ. 2020. Simulation code for Fig S2 from the distribution
of epistasis on simple fitness landscapes, Royal Society of London, 10.6084/m9.figshare.7957472.v1.
mla: Fraisse, Christelle, and John J. Welch. Simulation Code for Fig S2 from
the Distribution of Epistasis on Simple Fitness Landscapes. Royal Society
of London, 2020, doi:10.6084/m9.figshare.7957472.v1.
short: C. Fraisse, J.J. Welch, (2020).
date_created: 2021-08-06T11:18:15Z
date_published: 2020-10-15T00:00:00Z
date_updated: 2026-06-18T19:05:02Z
day: '15'
department:
- _id: BeVi
- _id: NiBa
doi: 10.6084/m9.figshare.7957472.v1
main_file_link:
- open_access: '1'
url: https://doi.org/10.6084/m9.figshare.7957472.v1
month: '10'
oa: 1
oa_version: Published Version
publisher: Royal Society of London
related_material:
record:
- id: '6467'
relation: used_in_publication
status: public
status: public
title: Simulation code for Fig S2 from the distribution of epistasis on simple fitness
landscapes
type: research_data_reference
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '9799'
abstract:
- lang: eng
text: Fitness interactions between mutations can influence a population’s evolution
in many different ways. While epistatic effects are difficult to measure precisely,
important information is captured by the mean and variance of log fitnesses for
individuals carrying different numbers of mutations. We derive predictions for
these quantities from a class of simple fitness landscapes, based on models of
optimizing selection on quantitative traits. We also explore extensions to the
models, including modular pleiotropy, variable effect sizes, mutational bias and
maladaptation of the wild type. We illustrate our approach by reanalysing a large
dataset of mutant effects in a yeast snoRNA. Though characterized by some large
epistatic effects, these data give a good overall fit to the non-epistatic null
model, suggesting that epistasis might have limited influence on the evolutionary
dynamics in this system. We also show how the amount of epistasis depends on both
the underlying fitness landscape and the distribution of mutations, and so is
expected to vary in consistent ways between new mutations, standing variation
and fixed mutations.
article_processing_charge: No
author:
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: John J.
full_name: Welch, John J.
last_name: Welch
citation:
ama: Fraisse C, Welch JJ. Simulation code for Fig S1 from the distribution of epistasis
on simple fitness landscapes. 2020. doi:10.6084/m9.figshare.7957469.v1
apa: Fraisse, C., & Welch, J. J. (2020). Simulation code for Fig S1 from the
distribution of epistasis on simple fitness landscapes. Royal Society of London.
https://doi.org/10.6084/m9.figshare.7957469.v1
chicago: Fraisse, Christelle, and John J. Welch. “Simulation Code for Fig S1 from
the Distribution of Epistasis on Simple Fitness Landscapes.” Royal Society of
London, 2020. https://doi.org/10.6084/m9.figshare.7957469.v1.
ieee: C. Fraisse and J. J. Welch, “Simulation code for Fig S1 from the distribution
of epistasis on simple fitness landscapes.” Royal Society of London, 2020.
ista: Fraisse C, Welch JJ. 2020. Simulation code for Fig S1 from the distribution
of epistasis on simple fitness landscapes, Royal Society of London, 10.6084/m9.figshare.7957469.v1.
mla: Fraisse, Christelle, and John J. Welch. Simulation Code for Fig S1 from
the Distribution of Epistasis on Simple Fitness Landscapes. Royal Society
of London, 2020, doi:10.6084/m9.figshare.7957469.v1.
short: C. Fraisse, J.J. Welch, (2020).
date_created: 2021-08-06T11:26:57Z
date_published: 2020-10-15T00:00:00Z
date_updated: 2026-06-18T19:05:02Z
day: '15'
department:
- _id: BeVi
- _id: NiBa
doi: 10.6084/m9.figshare.7957469.v1
main_file_link:
- open_access: '1'
url: https://doi.org/10.6084/m9.figshare.7957469.v1
month: '10'
oa: 1
oa_version: Published Version
publisher: Royal Society of London
related_material:
record:
- id: '6467'
relation: used_in_publication
status: public
status: public
title: Simulation code for Fig S1 from the distribution of epistasis on simple fitness
landscapes
type: research_data_reference
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
year: '2020'
...
---
_id: '7205'
abstract:
- lang: eng
text: Genetic incompatibilities contribute to reproductive isolation between many
diverging populations, but it is still unclear to what extent they play a role
if divergence happens with gene flow. In contact zones between the "Crab" and
"Wave" ecotypes of the snail Littorina saxatilis, divergent selection forms strong
barriers to gene flow, while the role of post‐zygotic barriers due to selection
against hybrids remains unclear. High embryo abortion rates in this species could
indicate the presence of such barriers. Post‐zygotic barriers might include genetic
incompatibilities (e.g. Dobzhansky–Muller incompatibilities) but also maladaptation,
both expected to be most pronounced in contact zones. In addition, embryo abortion
might reflect physiological stress on females and embryos independent of any genetic
stress. We examined all embryos of >500 females sampled outside and inside contact
zones of three populations in Sweden. Females' clutch size ranged from 0 to 1,011
embryos (mean 130 ± 123), and abortion rates varied between 0% and 100% (mean
12%). We described female genotypes by using a hybrid index based on hundreds
of SNPs differentiated between ecotypes with which we characterized female genotypes.
We also calculated female SNP heterozygosity and inversion karyotype. Clutch size
did not vary with female hybrid index, and abortion rates were only weakly related
to hybrid index in two sites but not at all in a third site. No additional variation
in abortion rate was explained by female SNP heterozygosity, but increased female
inversion heterozygosity added slightly to increased abortion. Our results show
only weak and probably biologically insignificant post‐zygotic barriers contributing
to ecotype divergence, and the high and variable abortion rates were marginally,
if at all, explained by hybrid index of females.
article_processing_charge: No
article_type: original
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Zuzanna
full_name: Zagrodzka, Zuzanna
last_name: Zagrodzka
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. Is embryo abortion
a post-zygotic barrier to gene flow between Littorina ecotypes? Journal of
Evolutionary Biology. 2020;33(3):342-351. doi:10.1111/jeb.13570
apa: Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., & Butlin, R.
K. (2020). Is embryo abortion a post-zygotic barrier to gene flow between Littorina
ecotypes? Journal of Evolutionary Biology. Wiley. https://doi.org/10.1111/jeb.13570
chicago: Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and
Roger K. Butlin. “Is Embryo Abortion a Post-Zygotic Barrier to Gene Flow between
Littorina Ecotypes?” Journal of Evolutionary Biology. Wiley, 2020. https://doi.org/10.1111/jeb.13570.
ieee: K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. K. Butlin, “Is
embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?,”
Journal of Evolutionary Biology, vol. 33, no. 3. Wiley, pp. 342–351, 2020.
ista: Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin RK. 2020. Is embryo
abortion a post-zygotic barrier to gene flow between Littorina ecotypes? Journal
of Evolutionary Biology. 33(3), 342–351.
mla: Johannesson, Kerstin, et al. “Is Embryo Abortion a Post-Zygotic Barrier to
Gene Flow between Littorina Ecotypes?” Journal of Evolutionary Biology,
vol. 33, no. 3, Wiley, 2020, pp. 342–51, doi:10.1111/jeb.13570.
short: K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R.K. Butlin, Journal
of Evolutionary Biology 33 (2020) 342–351.
date_created: 2019-12-22T23:00:43Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-07-10T11:54:22Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/jeb.13570
external_id:
isi:
- '000500954800001'
pmid:
- '31724256'
file:
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checksum: 7534ff0839709c0c5265c12d29432f03
content_type: application/pdf
creator: dernst
date_created: 2020-09-22T09:42:18Z
date_updated: 2020-09-22T09:42:18Z
file_id: '8553'
file_name: 2020_EvolBiology_Johannesson.pdf
file_size: 885611
relation: main_file
success: 1
file_date_updated: 2020-09-22T09:42:18Z
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issue: '3'
language:
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month: '03'
oa: 1
oa_version: Published Version
page: 342-351
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '13067'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Is embryo abortion a post-zygotic barrier to gene flow between Littorina ecotypes?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2020'
...
---
OA_place: publisher
OA_type: hybrid
_id: '7236'
abstract:
- lang: eng
text: The biotic interactions hypothesis posits that biotic interactions are more
important drivers of adaptation closer to the equator, evidenced by “stronger”
contemporary interactions (e.g. greater interaction rates) and/or patterns of
trait evolution consistent with a history of stronger interactions. Support for
the hypothesis is mixed, but few studies span tropical and temperate regions while
experimentally controlling for evolutionary history. Here, we integrate field
observations and common garden experiments to quantify the relative importance
of pollination and herbivory in a pair of tropical‐temperate congeneric perennial
herbs. Phytolacca rivinoides and P. americana are pioneer species native to the
Neotropics and the eastern USA, respectively. We compared plant‐pollinator and
plant‐herbivore interactions between three tropical populations of P. rivinoides
from Costa Rica and three temperate populations of P. americana from its northern
range edge in Michigan and Ohio. For some metrics of interaction importance, we
also included three subtropical populations of P. americana from its southern
range edge in Florida. This approach confounds species and region but allows us,
uniquely, to measure complementary proxies of interaction importance across a
tropical‐temperate range in one system. To test the prediction that lower‐latitude
plants are more reliant on insect pollinators, we quantified floral display and
reward, insect visitation rates, and self‐pollination ability (autogamy). To test
the prediction that lower‐latitude plants experience more herbivore pressure,
we quantified herbivory rates, herbivore abundance, and leaf palatability. We
found evidence supporting the biotic interactions hypothesis for most comparisons
between P. rivinoides and north‐temperate P. americana (floral display, insect
visitation, autogamy, herbivory, herbivore abundance, and young‐leaf palatability).
Results for subtropical P. americana populations, however, were typically not
intermediate between P. rivinoides and north‐temperate P. americana, as would
be predicted by a linear latitudinal gradient in interaction importance. Subtropical
young‐leaf palatability was intermediate, but subtropical mature leaves were the
least palatable, and pollination‐related traits did not differ between temperate
and subtropical regions. These nonlinear patterns of interaction importance suggest
future work to relate interaction importance to climatic or biotic thresholds.
In sum, we found that the biotic interactions hypothesis was more consistently
supported at the larger spatial scale of our study.
article_number: e01397
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Carina
full_name: Baskett, Carina
id: 3B4A7CE2-F248-11E8-B48F-1D18A9856A87
last_name: Baskett
orcid: 0000-0002-7354-8574
- first_name: Lucy
full_name: Schroeder, Lucy
last_name: Schroeder
- first_name: Marjorie G.
full_name: Weber, Marjorie G.
last_name: Weber
- first_name: Douglas W.
full_name: Schemske, Douglas W.
last_name: Schemske
citation:
ama: Baskett C, Schroeder L, Weber MG, Schemske DW. Multiple metrics of latitudinal
patterns in insect pollination and herbivory for a tropical‐temperate congener
pair. Ecological Monographs. 2020;90(1). doi:10.1002/ecm.1397
apa: Baskett, C., Schroeder, L., Weber, M. G., & Schemske, D. W. (2020). Multiple
metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate
congener pair. Ecological Monographs. Wiley. https://doi.org/10.1002/ecm.1397
chicago: Baskett, Carina, Lucy Schroeder, Marjorie G. Weber, and Douglas W. Schemske.
“Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory
for a Tropical‐temperate Congener Pair.” Ecological Monographs. Wiley,
2020. https://doi.org/10.1002/ecm.1397.
ieee: C. Baskett, L. Schroeder, M. G. Weber, and D. W. Schemske, “Multiple metrics
of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate
congener pair,” Ecological Monographs, vol. 90, no. 1. Wiley, 2020.
ista: Baskett C, Schroeder L, Weber MG, Schemske DW. 2020. Multiple metrics of latitudinal
patterns in insect pollination and herbivory for a tropical‐temperate congener
pair. Ecological Monographs. 90(1), e01397.
mla: Baskett, Carina, et al. “Multiple Metrics of Latitudinal Patterns in Insect
Pollination and Herbivory for a Tropical‐temperate Congener Pair.” Ecological
Monographs, vol. 90, no. 1, e01397, Wiley, 2020, doi:10.1002/ecm.1397.
short: C. Baskett, L. Schroeder, M.G. Weber, D.W. Schemske, Ecological Monographs
90 (2020).
date_created: 2020-01-07T12:47:07Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2025-04-14T07:44:07Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/ecm.1397
ec_funded: 1
external_id:
isi:
- '000508511600001'
file:
- access_level: open_access
checksum: ab8130c6e68101f5a091d05324c36f08
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:18:14Z
date_updated: 2020-07-14T12:47:54Z
file_id: '7469'
file_name: 2020_EcologMono_Baskett.pdf
file_size: 537941
relation: main_file
file_date_updated: 2020-07-14T12:47:54Z
has_accepted_license: '1'
intvolume: ' 90'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Ecological Monographs
publication_identifier:
eissn:
- 1557-7015
issn:
- 0012-9615
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiple metrics of latitudinal patterns in insect pollination and herbivory
for a tropical‐temperate congener pair
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 0043cee0-e5fc-11ee-9736-f83bc23afbf0
volume: 90
year: '2020'
...
---
_id: '13067'
abstract:
- lang: eng
text: Genetic incompatibilities contribute to reproductive isolation between many
diverging populations, but it is still unclear to what extent they play a role
if divergence happens with gene flow. In contact zones between the "Crab" and
"Wave" ecotypes of the snail Littorina saxatilis divergent selection forms strong
barriers to gene flow, while the role of postzygotic barriers due to selection
against hybrids remains unclear. High embryo abortion rates in this species could
indicate the presence of such barriers. Postzygotic barriers might include genetic
incompatibilities (e.g. Dobzhansky-Muller incompatibilities) but also maladaptation,
both expected to be most pronounced in contact zones. In addition, embryo abortion
might reflect physiological stress on females and embryos independent of any genetic
stress. We examined all embryos of >500 females sampled outside and inside
contact zones of three populations in Sweden. Females' clutch size ranged from
0 to 1011 embryos (mean 130±123) and abortion rates varied between 0 and100% (mean
12%). We described female genotypes by using a hybrid index based on hundreds
of SNPs differentiated between ecotypes with which we characterised female genotypes.
We also calculated female SNP heterozygosity and inversion karyotype. Clutch size
did not vary with female hybrid index and abortion rates were only weakly related
to hybrid index in two sites but not at all in a third site. No additional variation
in abortion rate was explained by female SNP heterozygosity, but increased female
inversion heterozygosity added slightly to increased abortion. Our results show
only weak and probably biologically insignificant postzygotic barriers contributing
to ecotype divergence and the high and variable abortion rates were marginally,
if at all, explained by hybrid index of females.
article_processing_charge: No
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Zuzanna
full_name: Zagrodzka, Zuzanna
last_name: Zagrodzka
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. Data from: Is embryo
abortion a postzygotic barrier to gene flow between Littorina ecotypes? 2019.
doi:10.5061/DRYAD.TB2RBNZWK'
apa: 'Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., & Butlin, R.
(2019). Data from: Is embryo abortion a postzygotic barrier to gene flow between
Littorina ecotypes? Dryad. https://doi.org/10.5061/DRYAD.TB2RBNZWK'
chicago: 'Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and
Roger Butlin. “Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow
between Littorina Ecotypes?” Dryad, 2019. https://doi.org/10.5061/DRYAD.TB2RBNZWK.'
ieee: 'K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. Butlin, “Data
from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?” Dryad, 2019.'
ista: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. 2019. Data from:
Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?,
Dryad, 10.5061/DRYAD.TB2RBNZWK.'
mla: 'Johannesson, Kerstin, et al. Data from: Is Embryo Abortion a Postzygotic
Barrier to Gene Flow between Littorina Ecotypes? Dryad, 2019, doi:10.5061/DRYAD.TB2RBNZWK.'
short: K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R. Butlin, (2019).
date_created: 2023-05-23T16:36:27Z
date_published: 2019-12-02T00:00:00Z
date_updated: 2025-07-10T11:54:22Z
day: '02'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.TB2RBNZWK
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.tb2rbnzwk
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '7205'
relation: used_in_publication
status: public
status: public
title: 'Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '5911'
abstract:
- lang: eng
text: Empirical data suggest that inversions in many species contain genes important
for intraspecific divergence and speciation, yet mechanisms of evolution remain
unclear. While genes inside an inversion are tightly linked, inversions are not
static but evolve separately from the rest of the genome by new mutations, recombination
within arrangements, and gene flux between arrangements. Inversion polymorphisms
are maintained by different processes, for example, divergent or balancing selection,
or a mix of multiple processes. Moreover, the relative roles of selection, drift,
mutation, and recombination will change over the lifetime of an inversion and
within its area of distribution. We believe inversions are central to the evolution
of many species, but we need many more data and new models to understand the complex
mechanisms involved.
article_processing_charge: No
article_type: original
author:
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
citation:
ama: Faria R, Johannesson K, Butlin RK, Westram AM. Evolving inversions. Trends
in Ecology and Evolution. 2019;34(3):239-248. doi:10.1016/j.tree.2018.12.005
apa: Faria, R., Johannesson, K., Butlin, R. K., & Westram, A. M. (2019). Evolving
inversions. Trends in Ecology and Evolution. Elsevier. https://doi.org/10.1016/j.tree.2018.12.005
chicago: Faria, Rui, Kerstin Johannesson, Roger K. Butlin, and Anja M Westram. “Evolving
Inversions.” Trends in Ecology and Evolution. Elsevier, 2019. https://doi.org/10.1016/j.tree.2018.12.005.
ieee: R. Faria, K. Johannesson, R. K. Butlin, and A. M. Westram, “Evolving inversions,”
Trends in Ecology and Evolution, vol. 34, no. 3. Elsevier, pp. 239–248,
2019.
ista: Faria R, Johannesson K, Butlin RK, Westram AM. 2019. Evolving inversions.
Trends in Ecology and Evolution. 34(3), 239–248.
mla: Faria, Rui, et al. “Evolving Inversions.” Trends in Ecology and Evolution,
vol. 34, no. 3, Elsevier, 2019, pp. 239–48, doi:10.1016/j.tree.2018.12.005.
short: R. Faria, K. Johannesson, R.K. Butlin, A.M. Westram, Trends in Ecology and
Evolution 34 (2019) 239–248.
date_created: 2019-02-03T22:59:15Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2026-04-16T09:48:52Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1016/j.tree.2018.12.005
ec_funded: 1
external_id:
isi:
- '000459899000013'
file:
- access_level: open_access
checksum: ef24572d6ebcc1452c067e05410cc4a2
content_type: application/pdf
creator: cziletti
date_created: 2020-01-09T10:55:58Z
date_updated: 2020-07-14T12:47:13Z
file_id: '7245'
file_name: 2019_Trends_Evolution_Faria.pdf
file_size: 1946795
relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: ' 34'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 239-248
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Trends in Ecology and Evolution
publication_identifier:
issn:
- 0169-5347
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolving inversions
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 34
year: '2019'
...
---
_id: '6022'
abstract:
- lang: eng
text: The evolution of new species is made easier when traits under divergent ecological
selection are also mating cues. Such ecological mating cues are now considered
more common than previously thought, but we still know little about the genetic
changes underlying their evolution or more generally about the genetic basis for
assortative mating behaviors. Both tight physical linkage and the existence of
large-effect preference loci will strengthen genetic associations between behavioral
and ecological barriers, promoting the evolution of assortative mating. The warning
patterns of Heliconius melpomene and H. cydno are under disruptive selection due
to increased predation of nonmimetic hybrids and are used during mate recognition.
We carried out a genome-wide quantitative trait locus (QTL) analysis of preference
behaviors between these species and showed that divergent male preference has
a simple genetic basis. We identify three QTLs that together explain a large proportion
(approximately 60%) of the difference in preference behavior observed between
the parental species. One of these QTLs is just 1.2 (0-4.8) centiMorgans (cM)
from the major color pattern gene optix, and, individually, all three have a large
effect on the preference phenotype. Genomic divergence between H. cydno and H.
melpomene is high but broadly heterogenous, and admixture is reduced at the preference-optix
color pattern locus but not the other preference QTLs. The simple genetic architecture
we reveal will facilitate the evolution and maintenance of new species despite
ongoing gene flow by coupling behavioral and ecological aspects of reproductive
isolation.
article_number: e2005902
article_processing_charge: No
author:
- first_name: Richard M.
full_name: Merrill, Richard M.
last_name: Merrill
- first_name: Pasi
full_name: Rastas, Pasi
last_name: Rastas
- first_name: Simon H.
full_name: Martin, Simon H.
last_name: Martin
- first_name: Maria C
full_name: Melo Hurtado, Maria C
id: 386D7308-F248-11E8-B48F-1D18A9856A87
last_name: Melo Hurtado
- first_name: Sarah
full_name: Barker, Sarah
last_name: Barker
- first_name: John
full_name: Davey, John
last_name: Davey
- first_name: W. Owen
full_name: Mcmillan, W. Owen
last_name: Mcmillan
- first_name: Chris D.
full_name: Jiggins, Chris D.
last_name: Jiggins
citation:
ama: Merrill RM, Rastas P, Martin SH, et al. Genetic dissection of assortative mating
behavior. PLoS Biology. 2019;17(2). doi:10.1371/journal.pbio.2005902
apa: Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S.,
Davey, J., … Jiggins, C. D. (2019). Genetic dissection of assortative mating behavior.
PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.2005902
chicago: Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado,
Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Genetic Dissection
of Assortative Mating Behavior.” PLoS Biology. Public Library of Science,
2019. https://doi.org/10.1371/journal.pbio.2005902.
ieee: R. M. Merrill et al., “Genetic dissection of assortative mating behavior,”
PLoS Biology, vol. 17, no. 2. Public Library of Science, 2019.
ista: Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan
WO, Jiggins CD. 2019. Genetic dissection of assortative mating behavior. PLoS
Biology. 17(2), e2005902.
mla: Merrill, Richard M., et al. “Genetic Dissection of Assortative Mating Behavior.”
PLoS Biology, vol. 17, no. 2, e2005902, Public Library of Science, 2019,
doi:10.1371/journal.pbio.2005902.
short: R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey,
W.O. Mcmillan, C.D. Jiggins, PLoS Biology 17 (2019).
date_created: 2019-02-17T22:59:21Z
date_published: 2019-02-07T00:00:00Z
date_updated: 2023-08-24T14:46:23Z
day: '07'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.2005902
external_id:
isi:
- '000460317100001'
file:
- access_level: open_access
checksum: 5f34001617ee729314ca520c049b1112
content_type: application/pdf
creator: dernst
date_created: 2019-02-18T14:57:24Z
date_updated: 2020-07-14T12:47:17Z
file_id: '6036'
file_name: 2019_PLOS_Merrill.pdf
file_size: 2005949
relation: main_file
file_date_updated: 2020-07-14T12:47:17Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '9801'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Genetic dissection of assortative mating behavior
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2019'
...
---
OA_place: publisher
_id: '6071'
abstract:
- lang: eng
text: 'Transcription factors, by binding to specific sequences on the DNA, control
the precise spatio-temporal expression of genes inside a cell. However, this specificity
is limited, leading to frequent incorrect binding of transcription factors that
might have deleterious consequences on the cell. By constructing a biophysical
model of TF-DNA binding in the context of gene regulation, I will first explore
how regulatory constraints can strongly shape the distribution of a population
in sequence space. Then, by directly linking this to a picture of multiple types
of transcription factors performing their functions simultaneously inside the
cell, I will explore the extent of regulatory crosstalk -- incorrect binding interactions
between transcription factors and binding sites that lead to erroneous regulatory
states -- and understand the constraints this places on the design of regulatory
systems. I will then develop a generic theoretical framework to investigate the
coevolution of multiple transcription factors and multiple binding sites, in the
context of a gene regulatory network that performs a certain function. As a particular
tractable version of this problem, I will consider the evolution of two transcription
factors when they transmit upstream signals to downstream target genes. Specifically,
I will describe the evolutionary steady states and the evolutionary pathways involved,
along with their timescales, of a system that initially undergoes a transcription
factor duplication event. To connect this important theoretical model to the prominent
biological event of transcription factor duplication giving rise to paralogous
families, I will then describe a bioinformatics analysis of C2H2 Zn-finger transcription
factors, a major family in humans, and focus on the patterns of evolution that
paralogs have undergone in their various protein domains in the recent past. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
citation:
ama: Prizak R. Coevolution of transcription factors and their binding sites in sequence
space. 2019. doi:10.15479/at:ista:th6071
apa: Prizak, R. (2019). Coevolution of transcription factors and their binding
sites in sequence space. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:th6071
chicago: Prizak, Roshan. “Coevolution of Transcription Factors and Their Binding
Sites in Sequence Space.” Institute of Science and Technology Austria, 2019. https://doi.org/10.15479/at:ista:th6071.
ieee: R. Prizak, “Coevolution of transcription factors and their binding sites in
sequence space,” Institute of Science and Technology Austria, 2019.
ista: Prizak R. 2019. Coevolution of transcription factors and their binding sites
in sequence space. Institute of Science and Technology Austria.
mla: Prizak, Roshan. Coevolution of Transcription Factors and Their Binding Sites
in Sequence Space. Institute of Science and Technology Austria, 2019, doi:10.15479/at:ista:th6071.
short: R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in
Sequence Space, Institute of Science and Technology Austria, 2019.
corr_author: '1'
date_created: 2019-03-06T16:16:10Z
date_published: 2019-03-11T00:00:00Z
date_updated: 2026-04-08T13:54:25Z
day: '11'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GaTk
- _id: NiBa
doi: 10.15479/at:ista:th6071
file:
- access_level: open_access
checksum: e60a72de35d270b31f1a23d50f224ec0
content_type: application/pdf
creator: rprizak
date_created: 2019-03-06T16:05:07Z
date_updated: 2020-07-14T12:47:18Z
file_id: '6072'
file_name: Thesis_final_PDFA_RoshanPrizak.pdf
file_size: 20995465
relation: main_file
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checksum: 67c2630333d05ebafef5f018863a8465
content_type: application/zip
creator: rprizak
date_created: 2019-03-06T16:09:39Z
date_updated: 2020-07-14T12:47:18Z
file_id: '6073'
file_name: thesis_v2_merge.zip
file_size: 85705272
relation: source_file
title: Latex files
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '189'
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '955'
relation: part_of_dissertation
status: public
- id: '1358'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
title: Coevolution of transcription factors and their binding sites in sequence space
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2019'
...
---
_id: '6089'
abstract:
- lang: eng
text: Pleiotropy is the well-established idea that a single mutation affects multiple
phenotypes. If a mutation has opposite effects on fitness when expressed in different
contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
the efficacy of selection by limiting the fixation of beneficial mutations through
adaptation, and the removal of deleterious mutations through purifying selection.
Although this has been widely discussed, in particular in the context of a putative
“gender load,” it has yet to be systematically quantified. In this work, we empirically
estimate to which extent different pleiotropic regimes impede the efficacy of
selection in Drosophila melanogaster. We use whole-genome polymorphism data from
a single African population and divergence data from D. simulans to estimate the
fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
of selection (DoS). After controlling for confounding covariates, we find that
the different pleiotropic regimes have a relatively small, but significant, effect
on selection efficacy. Specifically, our results suggest that pleiotropic sexual
antagonism may restrict the efficacy of selection, but that this conflict can
be resolved by limiting the expression of genes to the sex where they are beneficial.
Intermediate levels of pleiotropy across tissues and life stages can also lead
to maladaptation in D. melanogaster, due to inefficient purifying selection combined
with low frequency of mutations that confer a selective advantage. Thus, our study
highlights the need to consider the efficacy of selection in the context of antagonistic
pleiotropy, and of genetic conflict in general.
article_processing_charge: No
author:
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection
in drosophila melanogaster. Molecular biology and evolution. 2019;36(3):500-515.
doi:10.1093/molbev/msy246
apa: Fraisse, C., Puixeu Sala, G., & Vicoso, B. (2019). Pleiotropy modulates
the efficacy of selection in drosophila melanogaster. Molecular Biology and
Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msy246
chicago: Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy
Modulates the Efficacy of Selection in Drosophila Melanogaster.” Molecular
Biology and Evolution. Oxford University Press, 2019. https://doi.org/10.1093/molbev/msy246.
ieee: C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy
of selection in drosophila melanogaster,” Molecular biology and evolution,
vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.
ista: Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy
of selection in drosophila melanogaster. Molecular biology and evolution. 36(3),
500–515.
mla: Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection
in Drosophila Melanogaster.” Molecular Biology and Evolution, vol. 36,
no. 3, Oxford University Press, 2019, pp. 500–15, doi:10.1093/molbev/msy246.
short: C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36
(2019) 500–515.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2025-04-15T08:18:38Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/molbev/msy246
external_id:
isi:
- '000462585100006'
pmid:
- '30590559'
intvolume: ' 36'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pubmed/30590559
month: '03'
oa: 1
oa_version: Submitted Version
page: 500-515
pmid: 1
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28842-B22
name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular biology and evolution
publication_identifier:
eissn:
- 1537-1719
issn:
- 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
record:
- id: '5757'
relation: popular_science
status: public
scopus_import: '1'
status: public
title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2019'
...
---
_id: '6090'
abstract:
- lang: eng
text: Cells need to reliably sense external ligand concentrations to achieve various
biological functions such as chemotaxis or signaling. The molecular recognition
of ligands by surface receptors is degenerate in many systems, leading to crosstalk
between ligand-receptor pairs. Crosstalk is often thought of as a deviation from
optimal specific recognition, as the binding of noncognate ligands can interfere
with the detection of the receptor's cognate ligand, possibly leading to a false
triggering of a downstream signaling pathway. Here we quantify the optimal precision
of sensing the concentrations of multiple ligands by a collection of promiscuous
receptors. We demonstrate that crosstalk can improve precision in concentration
sensing and discrimination tasks. To achieve superior precision, the additional
information about ligand concentrations contained in short binding events of the
noncognate ligand should be exploited. We present a proofreading scheme to realize
an approximate estimation of multiple ligand concentrations that reaches a precision
close to the derived optimal bounds. Our results help rationalize the observed
ubiquity of receptor crosstalk in molecular sensing.
article_number: '022423'
article_processing_charge: No
author:
- first_name: Martín
full_name: Carballo-Pacheco, Martín
last_name: Carballo-Pacheco
- first_name: Jonathan
full_name: Desponds, Jonathan
last_name: Desponds
- first_name: Tatyana
full_name: Gavrilchenko, Tatyana
last_name: Gavrilchenko
- first_name: Andreas
full_name: Mayer, Andreas
last_name: Mayer
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
- first_name: Gautam
full_name: Reddy, Gautam
last_name: Reddy
- first_name: Ilya
full_name: Nemenman, Ilya
last_name: Nemenman
- first_name: Thierry
full_name: Mora, Thierry
last_name: Mora
citation:
ama: Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves
concentration sensing of multiple ligands. Physical Review E. 2019;99(2).
doi:10.1103/PhysRevE.99.022423
apa: Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R.,
Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing
of multiple ligands. Physical Review E. American Physical Society. https://doi.org/10.1103/PhysRevE.99.022423
chicago: Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas
Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor
Crosstalk Improves Concentration Sensing of Multiple Ligands.” Physical Review
E. American Physical Society, 2019. https://doi.org/10.1103/PhysRevE.99.022423.
ieee: M. Carballo-Pacheco et al., “Receptor crosstalk improves concentration
sensing of multiple ligands,” Physical Review E, vol. 99, no. 2. American
Physical Society, 2019.
ista: Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G,
Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of
multiple ligands. Physical Review E. 99(2), 022423.
mla: Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration
Sensing of Multiple Ligands.” Physical Review E, vol. 99, no. 2, 022423,
American Physical Society, 2019, doi:10.1103/PhysRevE.99.022423.
short: M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G.
Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).
date_created: 2019-03-10T22:59:20Z
date_published: 2019-02-26T00:00:00Z
date_updated: 2024-02-28T13:12:06Z
day: '26'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1103/PhysRevE.99.022423
external_id:
isi:
- '000459916500007'
intvolume: ' 99'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/448118v1.abstract
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review E
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Receptor crosstalk improves concentration sensing of multiple ligands
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2019'
...
---
_id: '6095'
abstract:
- lang: eng
text: Both classical and recent studies suggest that chromosomal inversion polymorphisms
are important in adaptation and speciation. However, biases in discovery and reporting
of inversions make it difficult to assess their prevalence and biological importance.
Here, we use an approach based on linkage disequilibrium among markers genotyped
for samples collected across a transect between contrasting habitats to detect
chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in
a single locality for the coastal marine snail, Littorina saxatilis. Patterns
of diversity in the field and of recombination in controlled crosses provide strong
evidence that at least the majority of these rearrangements are inversions. Most
show clinal changes in frequency between habitats, suggestive of divergent selection,
but only one appears to be fixed for different arrangements in the two habitats.
Consistent with widespread evidence for balancing selection on inversion polymorphisms,
we argue that a combination of heterosis and divergent selection can explain the
observed patterns and should be considered in other systems spanning environmental
gradients.
article_processing_charge: No
author:
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Pragya
full_name: Chaube, Pragya
last_name: Chaube
- first_name: Hernán E.
full_name: Morales, Hernán E.
last_name: Morales
- first_name: Tomas
full_name: Larsson, Tomas
last_name: Larsson
- first_name: Alan R.
full_name: Lemmon, Alan R.
last_name: Lemmon
- first_name: Emily M.
full_name: Lemmon, Emily M.
last_name: Lemmon
- first_name: Marina
full_name: Rafajlović, Marina
last_name: Rafajlović
- first_name: Marina
full_name: Panova, Marina
last_name: Panova
- first_name: Mark
full_name: Ravinet, Mark
last_name: Ravinet
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in
a hybrid zone between Littorina saxatilis ecotypes. Molecular Ecology.
2019;28(6):1375-1393. doi:10.1111/mec.14972
apa: Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon,
E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid
zone between Littorina saxatilis ecotypes. Molecular Ecology. Wiley. https://doi.org/10.1111/mec.14972
chicago: Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon,
Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements
in a Hybrid Zone between Littorina Saxatilis Ecotypes.” Molecular Ecology.
Wiley, 2019. https://doi.org/10.1111/mec.14972.
ieee: R. Faria et al., “Multiple chromosomal rearrangements in a hybrid zone
between Littorina saxatilis ecotypes,” Molecular Ecology, vol. 28, no.
6. Wiley, pp. 1375–1393, 2019.
ista: Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović
M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal
rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular
Ecology. 28(6), 1375–1393.
mla: Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between
Littorina Saxatilis Ecotypes.” Molecular Ecology, vol. 28, no. 6, Wiley,
2019, pp. 1375–93, doi:10.1111/mec.14972.
short: R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon,
M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin,
Molecular Ecology 28 (2019) 1375–1393.
date_created: 2019-03-10T22:59:21Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2023-08-24T14:50:27Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.14972
external_id:
isi:
- '000465219200013'
file:
- access_level: open_access
checksum: f915885756057ec0ca5912a41f46a887
content_type: application/pdf
creator: dernst
date_created: 2019-03-11T16:12:54Z
date_updated: 2020-07-14T12:47:19Z
file_id: '6097'
file_name: 2019_MolecularEcology_Faria.pdf
file_size: 1510715
relation: main_file
file_date_updated: 2020-07-14T12:47:19Z
has_accepted_license: '1'
intvolume: ' 28'
isi: 1
issue: '6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1375-1393
publication: Molecular Ecology
publication_identifier:
eissn:
- 1365-294X
issn:
- 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9837'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis
ecotypes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 28
year: '2019'
...
---
_id: '6230'
abstract:
- lang: eng
text: Great care is needed when interpreting claims about the genetic basis of human
variation based on data from genome-wide association studies.
article_number: e45380
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Joachim
full_name: Hermisson, Joachim
last_name: Hermisson
- first_name: Magnus
full_name: Nordborg, Magnus
last_name: Nordborg
citation:
ama: Barton NH, Hermisson J, Nordborg M. Why structure matters. eLife. 2019;8.
doi:10.7554/eLife.45380
apa: Barton, N. H., Hermisson, J., & Nordborg, M. (2019). Why structure matters.
ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.45380
chicago: Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure
Matters.” ELife. eLife Sciences Publications, 2019. https://doi.org/10.7554/eLife.45380.
ieee: N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” eLife,
vol. 8. eLife Sciences Publications, 2019.
ista: Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8,
e45380.
mla: Barton, Nicholas H., et al. “Why Structure Matters.” ELife, vol. 8,
e45380, eLife Sciences Publications, 2019, doi:10.7554/eLife.45380.
short: N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019).
date_created: 2019-04-07T21:59:15Z
date_published: 2019-03-21T00:00:00Z
date_updated: 2026-04-02T14:03:15Z
day: '21'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.7554/eLife.45380
external_id:
isi:
- '000461988300001'
file:
- access_level: open_access
checksum: 130d7544b57df4a6787e1263c2d7ea43
content_type: application/pdf
creator: dernst
date_created: 2019-04-11T11:43:38Z
date_updated: 2020-07-14T12:47:24Z
file_id: '6293'
file_name: 2019_eLife_Barton.pdf
file_size: 298466
relation: main_file
file_date_updated: 2020-07-14T12:47:24Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/
scopus_import: '1'
status: public
title: Why structure matters
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 8
year: '2019'
...
---
_id: '8281'
abstract:
- lang: eng
text: We review the history of population genetics, starting with its origins a
century ago from the synthesis between Mendel and Darwin's ideas, through to the
recent development of sophisticated schemes of inference from sequence data, based
on the coalescent. We explain the close relation between the coalescent and a
diffusion process, which we illustrate by their application to understand spatial
structure. We summarise the powerful methods available for analysis of multiple
loci, when linkage equilibrium can be assumed, and then discuss approaches to
the more challenging case, where associations between alleles require that we
follow genotype, rather than allele, frequencies. Though we can hardly cover the
whole of population genetics, we give an overview of the current state of the
subject, and future challenges to it.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison
last_name: Etheridge
citation:
ama: 'Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding
D, Moltke I, Marioni J, eds. Handbook of Statistical Genomics. 4th ed.
Wiley; 2019:115-144. doi:10.1002/9781119487845.ch4'
apa: Barton, N. H., & Etheridge, A. (2019). Mathematical models in population
genetics. In D. Balding, I. Moltke, & J. Marioni (Eds.), Handbook of statistical
genomics (4th ed., pp. 115–144). Wiley. https://doi.org/10.1002/9781119487845.ch4
chicago: Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population
Genetics.” In Handbook of Statistical Genomics, edited by David Balding,
Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. https://doi.org/10.1002/9781119487845.ch4.
ieee: N. H. Barton and A. Etheridge, “Mathematical models in population genetics,”
in Handbook of statistical genomics, 4th ed., D. Balding, I. Moltke, and
J. Marioni, Eds. Wiley, 2019, pp. 115–144.
ista: 'Barton NH, Etheridge A. 2019.Mathematical models in population genetics.
In: Handbook of statistical genomics. , 115–144.'
mla: Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population
Genetics.” Handbook of Statistical Genomics, edited by David Balding et
al., 4th ed., Wiley, 2019, pp. 115–44, doi:10.1002/9781119487845.ch4.
short: N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.),
Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144.
date_created: 2020-08-21T04:25:39Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2024-10-21T06:02:39Z
day: '29'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1002/9781119487845.ch4
edition: '4'
editor:
- first_name: David
full_name: Balding, David
last_name: Balding
- first_name: Ida
full_name: Moltke, Ida
last_name: Moltke
- first_name: John
full_name: Marioni, John
last_name: Marioni
external_id:
isi:
- '000261343000003'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 115-144
publication: Handbook of statistical genomics
publication_identifier:
isbn:
- '9781119429142'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mathematical models in population genetics
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '9801'
article_processing_charge: No
author:
- first_name: Richard M.
full_name: Merrill, Richard M.
last_name: Merrill
- first_name: Pasi
full_name: Rastas, Pasi
last_name: Rastas
- first_name: Simon H.
full_name: Martin, Simon H.
last_name: Martin
- first_name: Maria C
full_name: Melo Hurtado, Maria C
id: 386D7308-F248-11E8-B48F-1D18A9856A87
last_name: Melo Hurtado
- first_name: Sarah
full_name: Barker, Sarah
last_name: Barker
- first_name: John
full_name: Davey, John
last_name: Davey
- first_name: W. Owen
full_name: Mcmillan, W. Owen
last_name: Mcmillan
- first_name: Chris D.
full_name: Jiggins, Chris D.
last_name: Jiggins
citation:
ama: Merrill RM, Rastas P, Martin SH, et al. Raw behavioral data. 2019. doi:10.1371/journal.pbio.2005902.s006
apa: Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S.,
Davey, J., … Jiggins, C. D. (2019). Raw behavioral data. Public Library of Science.
https://doi.org/10.1371/journal.pbio.2005902.s006
chicago: Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado,
Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Raw Behavioral
Data.” Public Library of Science, 2019. https://doi.org/10.1371/journal.pbio.2005902.s006.
ieee: R. M. Merrill et al., “Raw behavioral data.” Public Library of Science,
2019.
ista: Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan
WO, Jiggins CD. 2019. Raw behavioral data, Public Library of Science, 10.1371/journal.pbio.2005902.s006.
mla: Merrill, Richard M., et al. Raw Behavioral Data. Public Library of Science,
2019, doi:10.1371/journal.pbio.2005902.s006.
short: R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey,
W.O. Mcmillan, C.D. Jiggins, (2019).
date_created: 2021-08-06T11:34:56Z
date_published: 2019-02-07T00:00:00Z
date_updated: 2023-08-24T14:46:23Z
day: '07'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.2005902.s006
month: '02'
oa_version: Published Version
publisher: Public Library of Science
related_material:
record:
- id: '6022'
relation: used_in_publication
status: public
status: public
title: Raw behavioral data
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9802'
abstract:
- lang: eng
text: This paper analyzes how partial selfing in a large source population influences
its ability to colonize a new habitat via the introduction of a few founder individuals.
Founders experience inbreeding depression due to partially recessive deleterious
alleles as well as maladaptation to the new environment due to selection on a
large number of additive loci. I first introduce a simplified version of the Inbreeding
History Model (Kelly, 2007) in order to characterize mutation-selection balance
in a large, partially selfing source population under selection involving multiple
non-identical loci. I then use individual-based simulations to study the eco-evolutionary
dynamics of founders establishing in the new habitat under a model of hard selection.
The study explores how selfing rate shapes establishment probabilities of founders
via effects on both inbreeding depression and adaptability to the new environment,
and also distinguishes the effects of selfing on the initial fitness of founders
from its effects on the long-term adaptive response of the populations they found.
A high rate of (but not complete) selfing is found to aid establishment over a
wide range of parameters, even in the absence of mate limitation. The sensitivity
of the results to assumptions about the nature of polygenic selection are discussed.
article_processing_charge: No
author:
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: 'Sachdeva H. Data from: Effect of partial selfing and polygenic selection on
establishment in a new habitat. 2019. doi:10.5061/dryad.8tp0900'
apa: 'Sachdeva, H. (2019). Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat. Dryad. https://doi.org/10.5061/dryad.8tp0900'
chicago: 'Sachdeva, Himani. “Data from: Effect of Partial Selfing and Polygenic
Selection on Establishment in a New Habitat.” Dryad, 2019. https://doi.org/10.5061/dryad.8tp0900.'
ieee: 'H. Sachdeva, “Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat.” Dryad, 2019.'
ista: 'Sachdeva H. 2019. Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat, Dryad, 10.5061/dryad.8tp0900.'
mla: 'Sachdeva, Himani. Data from: Effect of Partial Selfing and Polygenic Selection
on Establishment in a New Habitat. Dryad, 2019, doi:10.5061/dryad.8tp0900.'
short: H. Sachdeva, (2019).
date_created: 2021-08-06T11:45:11Z
date_published: 2019-07-16T00:00:00Z
date_updated: 2024-10-09T20:58:56Z
day: '16'
department:
- _id: NiBa
doi: 10.5061/dryad.8tp0900
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.8tp0900
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6680'
relation: used_in_publication
status: public
status: public
title: 'Data from: Effect of partial selfing and polygenic selection on establishment
in a new habitat'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9803'
abstract:
- lang: eng
text: Understanding the mechanisms causing phenotypic differences between females
and males has long fascinated evolutionary biologists. An extensive literature
exists on animal sexual dimorphism but less is known about sex differences in
plants, particularly the extent of geographical variation in sexual dimorphism
and its life-cycle dynamics. Here, we investigate patterns of genetically-based
sexual dimorphism in vegetative and reproductive traits of a wind-pollinated dioecious
plant, Rumex hastatulus, across three life-cycle stages using open-pollinated
families from 30 populations spanning the geographic range and chromosomal variation
(XY and XY1Y2) of the species. The direction and degree of sexual dimorphism was
highly variable among populations and life-cycle stages. Sex-specific differences
in reproductive function explained a significant amount of temporal change in
sexual dimorphism. For several traits, geographical variation in sexual dimorphism
was associated with bioclimatic parameters, likely due to the differential responses
of the sexes to climate. We found no systematic differences in sexual dimorphism
between chromosome races. Sex-specific trait differences in dioecious plants largely
result from a balance between sexual and natural selection on resource allocation.
Our results indicate that abiotic factors associated with geographical context
also play a role in modifying sexual dimorphism during the plant life cycle.
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: David
full_name: Field, David
last_name: Field
- first_name: Spencer C.H.
full_name: Barrett, Spencer C.H.
last_name: Barrett
citation:
ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Data from: Variation in sexual
dimorphism in a wind-pollinated plant: the influence of geographical context and
life-cycle dynamics. 2019. doi:10.5061/dryad.n1701c9'
apa: 'Puixeu Sala, G., Pickup, M., Field, D., & Barrett, S. C. H. (2019). Data
from: Variation in sexual dimorphism in a wind-pollinated plant: the influence
of geographical context and life-cycle dynamics. Dryad. https://doi.org/10.5061/dryad.n1701c9'
chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
“Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence
of Geographical Context and Life-Cycle Dynamics.” Dryad, 2019. https://doi.org/10.5061/dryad.n1701c9.'
ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Data from: Variation
in sexual dimorphism in a wind-pollinated plant: the influence of geographical
context and life-cycle dynamics.” Dryad, 2019.'
ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Data from: Variation
in sexual dimorphism in a wind-pollinated plant: the influence of geographical
context and life-cycle dynamics, Dryad, 10.5061/dryad.n1701c9.'
mla: 'Puixeu Sala, Gemma, et al. Data from: Variation in Sexual Dimorphism in
a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle
Dynamics. Dryad, 2019, doi:10.5061/dryad.n1701c9.'
short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, (2019).
date_created: 2021-08-06T11:48:42Z
date_published: 2019-07-22T00:00:00Z
date_updated: 2026-04-07T13:25:33Z
day: '22'
department:
- _id: NiBa
- _id: BeVi
doi: 10.5061/dryad.n1701c9
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.n1701c9
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6831'
relation: used_in_publication
status: public
- id: '14058'
relation: used_in_publication
status: public
status: public
title: 'Data from: Variation in sexual dimorphism in a wind-pollinated plant: the
influence of geographical context and life-cycle dynamics'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...