---
_id: '5550'
abstract:
- lang: eng
  text: "We collected flower colour information on species in the tribe Antirrhineae
    from taxonomic literature. We also retreived molecular data from GenBank for as
    many of these species as possible to estimate phylogenetic relationships among
    these taxa. We then used the R package 'diversitree' to examine patterns of evolutionary
    transitions between anthocyanin and yellow pigmentation across the phylogeny.\r\n\r\nFor
    full details of the methods see:\r\nEllis TJ and Field DL \"Repeated gains in
    yellow and anthocyanin pigmentation in flower colour transitions in the Antirrhineae”,
    Annals of Botany (in press)"
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
- first_name: David
  full_name: Field, David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
  orcid: 0000-0002-4014-8478
citation:
  ama: Ellis T, Field D. Flower colour data and phylogeny (NEXUS) files. 2016. doi:<a
    href="https://doi.org/10.15479/AT:ISTA:34">10.15479/AT:ISTA:34</a>
  apa: Ellis, T., &#38; Field, D. (2016). Flower colour data and phylogeny (NEXUS)
    files. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:34">https://doi.org/10.15479/AT:ISTA:34</a>
  chicago: Ellis, Thomas, and David Field. “Flower Colour Data and Phylogeny (NEXUS)
    Files.” Institute of Science and Technology Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:34">https://doi.org/10.15479/AT:ISTA:34</a>.
  ieee: T. Ellis and D. Field, “Flower colour data and phylogeny (NEXUS) files.” Institute
    of Science and Technology Austria, 2016.
  ista: Ellis T, Field D. 2016. Flower colour data and phylogeny (NEXUS) files, Institute
    of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:34">10.15479/AT:ISTA:34</a>.
  mla: Ellis, Thomas, and David Field. <i>Flower Colour Data and Phylogeny (NEXUS)
    Files</i>. Institute of Science and Technology Austria, 2016, doi:<a href="https://doi.org/10.15479/AT:ISTA:34">10.15479/AT:ISTA:34</a>.
  short: T. Ellis, D. Field, (2016).
datarep_id: '34'
date_created: 2018-12-12T12:31:29Z
date_published: 2016-02-19T00:00:00Z
date_updated: 2025-09-22T07:32:43Z
day: '19'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:34
file:
- access_level: open_access
  checksum: 950f85b80427d357bfeff09608ba02e9
  content_type: application/zip
  creator: system
  date_created: 2018-12-12T13:02:27Z
  date_updated: 2020-07-14T12:47:00Z
  file_id: '5594'
  file_name: IST-2016-34-v1+1_tellis_flower_colour_data.zip
  file_size: 4468543
  relation: main_file
file_date_updated: 2020-07-14T12:47:00Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
publist_id: '5828'
related_material:
  record:
  - id: '1382'
    relation: research_paper
    status: public
status: public
title: Flower colour data and phylogeny (NEXUS) files
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '9710'
abstract:
- lang: eng
  text: Much of quantitative genetics is based on the ‘infinitesimal model’, under
    which selection has a negligible effect on the genetic variance. This is typically
    justified by assuming a very large number of loci with additive effects. However,
    it applies even when genes interact, provided that the number of loci is large
    enough that selection on each of them is weak relative to random drift. In the
    long term, directional selection will change allele frequencies, but even then,
    the effects of epistasis on the ultimate change in trait mean due to selection
    may be modest. Stabilising selection can maintain many traits close to their optima,
    even when the underlying alleles are weakly selected. However, the number of traits
    that can be optimised is apparently limited to ~4Ne by the ‘drift load’, and this
    is hard to reconcile with the apparent complexity of many organisms. Just as for
    the mutation load, this limit can be evaded by a particular form of negative epistasis.
    A more robust limit is set by the variance in reproductive success. This suggests
    that selection accumulates information most efficiently in the infinitesimal regime,
    when selection on individual alleles is weak, and comparable with random drift.
    A review of evidence on selection strength suggests that although most variance
    in fitness may be because of alleles with large Nes, substantial amounts of adaptation
    may be because of alleles in the infinitesimal regime, in which epistasis has
    modest effects.
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Barton NH. Data from: How does epistasis influence the response to selection?
    2016. doi:<a href="https://doi.org/10.5061/dryad.s5s7r">10.5061/dryad.s5s7r</a>'
  apa: 'Barton, N. H. (2016). Data from: How does epistasis influence the response
    to selection? Dryad. <a href="https://doi.org/10.5061/dryad.s5s7r">https://doi.org/10.5061/dryad.s5s7r</a>'
  chicago: 'Barton, Nicholas H. “Data from: How Does Epistasis Influence the Response
    to Selection?” Dryad, 2016. <a href="https://doi.org/10.5061/dryad.s5s7r">https://doi.org/10.5061/dryad.s5s7r</a>.'
  ieee: 'N. H. Barton, “Data from: How does epistasis influence the response to selection?”
    Dryad, 2016.'
  ista: 'Barton NH. 2016. Data from: How does epistasis influence the response to
    selection?, Dryad, <a href="https://doi.org/10.5061/dryad.s5s7r">10.5061/dryad.s5s7r</a>.'
  mla: 'Barton, Nicholas H. <i>Data from: How Does Epistasis Influence the Response
    to Selection?</i> Dryad, 2016, doi:<a href="https://doi.org/10.5061/dryad.s5s7r">10.5061/dryad.s5s7r</a>.'
  short: N.H. Barton, (2016).
date_created: 2021-07-23T11:45:47Z
date_published: 2016-09-23T00:00:00Z
date_updated: 2025-04-15T07:11:02Z
day: '23'
department:
- _id: NiBa
doi: 10.5061/dryad.s5s7r
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.s5s7r
month: '09'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
  record:
  - id: '1199'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: How does epistasis influence the response to selection?'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2016'
...
---
_id: '9862'
article_processing_charge: No
author:
- first_name: Camille
  full_name: Roux, Camille
  last_name: Roux
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Jonathan
  full_name: Romiguier, Jonathan
  last_name: Romiguier
- first_name: Youann
  full_name: Anciaux, Youann
  last_name: Anciaux
- first_name: Nicolas
  full_name: Galtier, Nicolas
  last_name: Galtier
- first_name: Nicolas
  full_name: Bierne, Nicolas
  last_name: Bierne
citation:
  ama: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. Simulation
    study to test the robustness of ABC in face of recent times of divergence. 2016.
    doi:<a href="https://doi.org/10.1371/journal.pbio.2000234.s016">10.1371/journal.pbio.2000234.s016</a>
  apa: Roux, C., Fraisse, C., Romiguier, J., Anciaux, Y., Galtier, N., &#38; Bierne,
    N. (2016). Simulation study to test the robustness of ABC in face of recent times
    of divergence. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.2000234.s016">https://doi.org/10.1371/journal.pbio.2000234.s016</a>
  chicago: Roux, Camille, Christelle Fraisse, Jonathan Romiguier, Youann Anciaux,
    Nicolas Galtier, and Nicolas Bierne. “Simulation Study to Test the Robustness
    of ABC in Face of Recent Times of Divergence.” Public Library of Science, 2016.
    <a href="https://doi.org/10.1371/journal.pbio.2000234.s016">https://doi.org/10.1371/journal.pbio.2000234.s016</a>.
  ieee: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, and N. Bierne,
    “Simulation study to test the robustness of ABC in face of recent times of divergence.”
    Public Library of Science, 2016.
  ista: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. 2016. Simulation
    study to test the robustness of ABC in face of recent times of divergence, Public
    Library of Science, <a href="https://doi.org/10.1371/journal.pbio.2000234.s016">10.1371/journal.pbio.2000234.s016</a>.
  mla: Roux, Camille, et al. <i>Simulation Study to Test the Robustness of ABC in
    Face of Recent Times of Divergence</i>. Public Library of Science, 2016, doi:<a
    href="https://doi.org/10.1371/journal.pbio.2000234.s016">10.1371/journal.pbio.2000234.s016</a>.
  short: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, N. Bierne, (2016).
date_created: 2021-08-10T08:20:17Z
date_updated: 2025-09-22T09:55:08Z
day: '27'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1371/journal.pbio.2000234.s016
month: '12'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '1158'
    relation: used_in_publication
    status: public
status: public
title: Simulation study to test the robustness of ABC in face of recent times of divergence
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2016'
...
---
_id: '9863'
article_processing_charge: No
author:
- first_name: Camille
  full_name: Roux, Camille
  last_name: Roux
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Jonathan
  full_name: Romiguier, Jonathan
  last_name: Romiguier
- first_name: Youann
  full_name: Anciaux, Youann
  last_name: Anciaux
- first_name: Nicolas
  full_name: Galtier, Nicolas
  last_name: Galtier
- first_name: Nicolas
  full_name: Bierne, Nicolas
  last_name: Bierne
citation:
  ama: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. Accessions
    of surveyed individuals, geographic locations and summary statistics. 2016. doi:<a
    href="https://doi.org/10.1371/journal.pbio.2000234.s017">10.1371/journal.pbio.2000234.s017</a>
  apa: Roux, C., Fraisse, C., Romiguier, J., Anciaux, Y., Galtier, N., &#38; Bierne,
    N. (2016). Accessions of surveyed individuals, geographic locations and summary
    statistics. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.2000234.s017">https://doi.org/10.1371/journal.pbio.2000234.s017</a>
  chicago: Roux, Camille, Christelle Fraisse, Jonathan Romiguier, Youann Anciaux,
    Nicolas Galtier, and Nicolas Bierne. “Accessions of Surveyed Individuals, Geographic
    Locations and Summary Statistics.” Public Library of Science, 2016. <a href="https://doi.org/10.1371/journal.pbio.2000234.s017">https://doi.org/10.1371/journal.pbio.2000234.s017</a>.
  ieee: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, and N. Bierne,
    “Accessions of surveyed individuals, geographic locations and summary statistics.”
    Public Library of Science, 2016.
  ista: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. 2016. Accessions
    of surveyed individuals, geographic locations and summary statistics, Public Library
    of Science, <a href="https://doi.org/10.1371/journal.pbio.2000234.s017">10.1371/journal.pbio.2000234.s017</a>.
  mla: Roux, Camille, et al. <i>Accessions of Surveyed Individuals, Geographic Locations
    and Summary Statistics</i>. Public Library of Science, 2016, doi:<a href="https://doi.org/10.1371/journal.pbio.2000234.s017">10.1371/journal.pbio.2000234.s017</a>.
  short: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, N. Bierne, (2016).
date_created: 2021-08-10T08:22:52Z
date_updated: 2025-09-22T09:55:09Z
day: '27'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1371/journal.pbio.2000234.s017
month: '12'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '1158'
    relation: used_in_publication
    status: public
status: public
title: Accessions of surveyed individuals, geographic locations and summary statistics
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2016'
...
---
_id: '9864'
abstract:
- lang: eng
  text: Viral capsids are structurally constrained by interactions among the amino
    acids (AAs) of their constituent proteins. Therefore, epistasis is expected to
    evolve among physically interacting sites and to influence the rates of substitution.
    To study the evolution of epistasis, we focused on the major structural protein
    of the ϕX174 phage family by, first, reconstructing the ancestral protein sequences
    of 18 species using a Bayesian statistical framework. The inferred ancestral reconstruction
    differed at eight AAs, for a total of 256 possible ancestral haplotypes. For each
    ancestral haplotype and the extant species, we estimated, in silico, the distribution
    of free energies and epistasis of the capsid structure. We found that free energy
    has not significantly increased but epistasis has. We decomposed epistasis up
    to fifth order and found that higher-order epistasis sometimes compensates pairwise
    interactions making the free energy seem additive. The dN/dS ratio is low, suggesting
    strong purifying selection, and that structure is under stabilizing selection.
    We synthesized phages carrying ancestral haplotypes of the coat protein gene and
    measured their fitness experimentally. Our findings indicate that stabilizing
    mutations can have higher fitness, and that fitness optima do not necessarily
    coincide with energy minima.
article_processing_charge: No
author:
- first_name: Rodrigo A
  full_name: Fernandes Redondo, Rodrigo A
  id: 409D5C96-F248-11E8-B48F-1D18A9856A87
  last_name: Fernandes Redondo
  orcid: 0000-0002-5837-2793
- first_name: Harold
  full_name: de Vladar, Harold
  id: 2A181218-F248-11E8-B48F-1D18A9856A87
  last_name: de Vladar
  orcid: 0000-0002-5985-7653
- first_name: Tomasz
  full_name: Włodarski, Tomasz
  last_name: Włodarski
- first_name: Jonathan P
  full_name: Bollback, Jonathan P
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
citation:
  ama: Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. Data from evolutionary
    interplay between structure, energy and epistasis in the coat protein of the ϕX174
    phage family. 2016. doi:<a href="https://doi.org/10.6084/m9.figshare.4315652.v1">10.6084/m9.figshare.4315652.v1</a>
  apa: Fernandes Redondo, R. A., de Vladar, H., Włodarski, T., &#38; Bollback, J.
    P. (2016). Data from evolutionary interplay between structure, energy and epistasis
    in the coat protein of the ϕX174 phage family. The Royal Society. <a href="https://doi.org/10.6084/m9.figshare.4315652.v1">https://doi.org/10.6084/m9.figshare.4315652.v1</a>
  chicago: Fernandes Redondo, Rodrigo A, Harold de Vladar, Tomasz Włodarski, and Jonathan
    P Bollback. “Data from Evolutionary Interplay between Structure, Energy and Epistasis
    in the Coat Protein of the ΦX174 Phage Family.” The Royal Society, 2016. <a href="https://doi.org/10.6084/m9.figshare.4315652.v1">https://doi.org/10.6084/m9.figshare.4315652.v1</a>.
  ieee: R. A. Fernandes Redondo, H. de Vladar, T. Włodarski, and J. P. Bollback, “Data
    from evolutionary interplay between structure, energy and epistasis in the coat
    protein of the ϕX174 phage family.” The Royal Society, 2016.
  ista: Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. 2016. Data from
    evolutionary interplay between structure, energy and epistasis in the coat protein
    of the ϕX174 phage family, The Royal Society, <a href="https://doi.org/10.6084/m9.figshare.4315652.v1">10.6084/m9.figshare.4315652.v1</a>.
  mla: Fernandes Redondo, Rodrigo A., et al. <i>Data from Evolutionary Interplay between
    Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family</i>.
    The Royal Society, 2016, doi:<a href="https://doi.org/10.6084/m9.figshare.4315652.v1">10.6084/m9.figshare.4315652.v1</a>.
  short: R.A. Fernandes Redondo, H. de Vladar, T. Włodarski, J.P. Bollback, (2016).
date_created: 2021-08-10T08:29:47Z
date_published: 2016-12-14T00:00:00Z
date_updated: 2025-07-10T11:49:59Z
day: '14'
department:
- _id: NiBa
- _id: JoBo
doi: 10.6084/m9.figshare.4315652.v1
main_file_link:
- open_access: '1'
  url: https://doi.org/10.6084/m9.figshare.4315652.v1
month: '12'
oa: 1
oa_version: Published Version
publisher: The Royal Society
related_material:
  record:
  - id: '1077'
    relation: used_in_publication
    status: public
status: public
title: Data from evolutionary interplay between structure, energy and epistasis in
  the coat protein of the ϕX174 phage family
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2016'
...
---
OA_place: publisher
_id: '1125'
abstract:
- lang: eng
  text: "Natural environments are never constant but subject to spatial and temporal
    change on\r\nall scales, increasingly so due to human activity. Hence, it is crucial
    to understand the\r\nimpact of environmental variation on evolutionary processes.
    In this thesis, I present\r\nthree topics that share the common theme of environmental
    variation, yet illustrate its\r\neffect from different perspectives.\r\nFirst,
    I show how a temporally fluctuating environment gives rise to second-order\r\nselection
    on a modifier for stress-induced mutagenesis. Without fluctuations, when\r\npopulations
    are adapted to their environment, mutation rates are minimized. I argue\r\nthat
    a stress-induced mutator mechanism may only be maintained if the population is\r\nrepeatedly
    subjected to diverse environmental challenges, and I outline implications of\r\nthe
    presented results to antibiotic treatment strategies.\r\nSecond, I discuss my
    work on the evolution of dispersal. Besides reproducing\r\nknown results about
    the effect of heterogeneous habitats on dispersal, it identifies\r\nspatial changes
    in dispersal type frequencies as a source for selection for increased\r\npropensities
    to disperse. This concept contains effects of relatedness that are known\r\nto
    promote dispersal, and I explain how it identifies other forces selecting for
    dispersal\r\nand puts them on a common scale.\r\nThird, I analyse genetic variances
    of phenotypic traits under multivariate stabilizing\r\nselection. For the case
    of constant environments, I generalize known formulae of\r\nequilibrium variances
    to multiple traits and discuss how the genetic variance of a focal\r\ntrait is
    influenced by selection on background traits. I conclude by presenting ideas and\r\npreliminary
    work aiming at including environmental fluctuations in the form of moving\r\ntrait
    optima into the model."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sebastian
  full_name: Novak, Sebastian
  id: 461468AE-F248-11E8-B48F-1D18A9856A87
  last_name: Novak
  orcid: 0000-0002-2519-824X
citation:
  ama: Novak S. Evolutionary proccesses in variable emvironments. 2016.
  apa: Novak, S. (2016). <i>Evolutionary proccesses in variable emvironments</i>.
    Institute of Science and Technology Austria.
  chicago: Novak, Sebastian. “Evolutionary Proccesses in Variable Emvironments.” Institute
    of Science and Technology Austria, 2016.
  ieee: S. Novak, “Evolutionary proccesses in variable emvironments,” Institute of
    Science and Technology Austria, 2016.
  ista: Novak S. 2016. Evolutionary proccesses in variable emvironments. Institute
    of Science and Technology Austria.
  mla: Novak, Sebastian. <i>Evolutionary Proccesses in Variable Emvironments</i>.
    Institute of Science and Technology Austria, 2016.
  short: S. Novak, Evolutionary Proccesses in Variable Emvironments, Institute of
    Science and Technology Austria, 2016.
corr_author: '1'
date_created: 2018-12-11T11:50:17Z
date_published: 2016-07-01T00:00:00Z
date_updated: 2026-07-29T11:27:43Z
day: '01'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: NiBa
- _id: GradSch
doi_confirm: '1'
file:
- access_level: closed
  checksum: 81dcc838dfcf7aa0b1a27ecf4fe2da4e
  content_type: application/pdf
  creator: dernst
  date_created: 2019-08-13T09:01:00Z
  date_updated: 2019-08-13T09:01:00Z
  file_id: '6811'
  file_name: Novak_thesis.pdf
  file_size: 3564901
  relation: main_file
- access_level: open_access
  checksum: 30808d2f7ca920e09f63a95cdc49bffd
  content_type: application/pdf
  creator: dernst
  date_created: 2021-02-22T13:42:47Z
  date_updated: 2021-02-22T13:42:47Z
  file_id: '9186'
  file_name: 2016_Novak_Thesis.pdf
  file_size: 2814384
  relation: main_file
  success: 1
file_date_updated: 2021-02-22T13:42:47Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '124'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6235'
related_material:
  record:
  - id: '2023'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: Evolutionary proccesses in variable emvironments
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2016'
...
---
OA_place: publisher
_id: '1131'
abstract:
- lang: eng
  text: "Evolution of gene regulation is important for phenotypic evolution and diversity.
    Sequence-specific binding of regulatory proteins is one of the key regulatory
    mechanisms determining gene expression. Although there has been intense interest
    in evolution of regulatory binding sites in the last decades, a theoretical understanding
    is far from being complete. In this thesis, I aim at a better understanding of
    the evolution of transcriptional regulatory binding sequences by using biophysical
    and population genetic models.\r\nIn the first part of the thesis, I discuss how
    to formulate the evolutionary dynamics of binding se- quences in a single isolated
    binding site and in promoter/enhancer regions. I develop a theoretical framework
    bridging between a thermodynamical model for transcription and a mutation-selection-drift
    model for monomorphic populations. I mainly address the typical evolutionary rates,
    and how they de- pend on biophysical parameters (e.g. binding length and specificity)
    and population genetic parameters (e.g. population size and selection strength).\r\nIn
    the second part of the thesis, I analyse empirical data for a better evolutionary
    and biophysical understanding of sequence-specific binding of bacterial RNA polymerase.
    First, I infer selection on regulatory and non-regulatory binding sites of RNA
    polymerase in the E. coli K12 genome. Second, I infer the chemical potential of
    RNA polymerase, an important but unknown physical parameter defining the threshold
    energy for strong binding. Furthermore, I try to understand the relation between
    the lac promoter sequence diversity and the LacZ activity variation among 20 bacterial
    isolates by constructing a simple but biophysically motivated gene expression
    model. Lastly, I lay out a statistical framework to predict adaptive point mutations
    in de novo promoter evolution in a selection experiment."
acknowledgement: This PhD thesis may not have been completed without the help and
  care I received from some peo- ple during my PhD life. I am especially grateful
  to Tiago Paixao, Gasper Tkacik, Nick Barton, not only for their scientific advices
  but also for their patience and support. I thank Calin Guet and Jonathan Bollback
  for allowing me to “play around” in their labs and get some experience on experimental
  evolution. I thank Magdalena Steinrueck and Fabienne Jesse for collaborating and
  sharing their experimental data with me. I thank Johannes Jaeger for reviewing my
  thesis. I thank all members of Barton group (aka bartonians) for their feedback,
  and all workers of IST Austria for making the best working conditions. Lastly, I
  thank two special women, Nejla Sag ̆lam and Setenay Dog ̆an, for their continuous
  support and encouragement. I truly had a great chance of having right people around
  me.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
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  full_name: Tugrul, Murat
  id: 37C323C6-F248-11E8-B48F-1D18A9856A87
  last_name: Tugrul
  orcid: 0000-0002-8523-0758
citation:
  ama: Tugrul M. Evolution of transcriptional regulatory sequences. 2016.
  apa: Tugrul, M. (2016). <i>Evolution of transcriptional regulatory sequences</i>.
    Institute of Science and Technology Austria.
  chicago: Tugrul, Murat. “Evolution of Transcriptional Regulatory Sequences.” Institute
    of Science and Technology Austria, 2016.
  ieee: M. Tugrul, “Evolution of transcriptional regulatory sequences,” Institute
    of Science and Technology Austria, 2016.
  ista: Tugrul M. 2016. Evolution of transcriptional regulatory sequences. Institute
    of Science and Technology Austria.
  mla: Tugrul, Murat. <i>Evolution of Transcriptional Regulatory Sequences</i>. Institute
    of Science and Technology Austria, 2016.
  short: M. Tugrul, Evolution of Transcriptional Regulatory Sequences, Institute of
    Science and Technology Austria, 2016.
corr_author: '1'
date_created: 2018-12-11T11:50:19Z
date_published: 2016-07-01T00:00:00Z
date_updated: 2026-07-29T11:31:14Z
day: '01'
ddc:
- '576'
degree_awarded: PhD
department:
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- _id: GradSch
doi_confirm: '1'
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publisher: Institute of Science and Technology Austria
publist_id: '6229'
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  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: Evolution of transcriptional regulatory sequences
type: dissertation
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...
---
_id: '5554'
abstract:
- lang: eng
  text: "The data stored here is used in Murat Tugrul's PhD thesis (Chapter 3), which
    is related to the evolution of bacterial RNA polymerase binding.\r\nMagdalena
    Steinrueck (PhD Student in Calin Guet's group at IST Austria) performed the experiments
    and created the data on de novo promoter evolution. Fabienne Jesse (PhD Student
    in Jon Bollback's group at IST Austria) performed the experiments and created
    the data on lac promoter evolution."
article_processing_charge: No
author:
- first_name: Murat
  full_name: Tugrul, Murat
  id: 37C323C6-F248-11E8-B48F-1D18A9856A87
  last_name: Tugrul
  orcid: 0000-0002-8523-0758
citation:
  ama: Tugrul M. Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase.
    2016. doi:<a href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>
  apa: Tugrul, M. (2016). Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:43">https://doi.org/10.15479/AT:ISTA:43</a>
  chicago: Tugrul, Murat. “Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase.” Institute of Science and Technology Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:43">https://doi.org/10.15479/AT:ISTA:43</a>.
  ieee: M. Tugrul, “Experimental Data for Binding Site Evolution of Bacterial RNA
    Polymerase.” Institute of Science and Technology Austria, 2016.
  ista: Tugrul M. 2016. Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>.
  mla: Tugrul, Murat. <i>Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase</i>. Institute of Science and Technology Austria, 2016, doi:<a
    href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>.
  short: M. Tugrul, (2016).
contributor:
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  first_name: Magdalena
  id: 2C023F40-F248-11E8-B48F-1D18A9856A87
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  first_name: Fabienne
  id: 4C8C26A4-F248-11E8-B48F-1D18A9856A87
  last_name: Jesse
datarep_id: '43'
date_created: 2018-12-12T12:31:30Z
date_published: 2016-05-12T00:00:00Z
date_updated: 2026-07-29T11:31:13Z
day: '12'
department:
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- _id: JoBo
doi: 10.15479/AT:ISTA:43
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keyword:
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- de novo promoter evolution
- lac promoter
month: '05'
oa: 1
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publisher: Institute of Science and Technology Austria
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title: Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase
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abstract:
- lang: eng
  text: Hybrid zones represent evolutionary laboratories, where recombination brings
    together alleles in combinations which have not previously been tested by selection.
    This provides an excellent opportunity to test the effect of molecular variation
    on fitness, and how this variation is able to spread through populations in a
    natural context. The snapdragon Antirrhinum majus is polymorphic in the wild for
    two loci controlling the distribution of yellow and magenta floral pigments. Where
    the yellow A. m. striatum and the magenta A. m. pseudomajus meet along a valley
    in the Spanish Pyrenees they form a stable hybrid zone Alleles at these loci recombine
    to give striking transgressive variation for flower colour. The sharp transition
    in phenotype over ~1km implies strong selection maintaining the hybrid zone. An
    indirect assay of pollinator visitation in the field found that pollinators forage
    in a positive-frequency dependent manner on Antirrhinum, matching previous data
    on fruit set. Experimental arrays and paternity analysis of wild-pollinated seeds
    demonstrated assortative mating for pigmentation alleles, and that pollinator
    behaviour alone is sufficient to explain this pattern. Selection by pollinators
    should be sufficiently strong to maintain the hybrid zone, although other mechanisms
    may be at work. At a broader scale I examined evolutionary transitions between
    yellow and anthocyanin pigmentation in the tribe Antirrhinae, and found that selection
    has acted strate that pollinators are a major determinant of reproductive success
    and mating patterns in wild Antirrhinum.
acknowledgement: "I am indebted to many people for their support during my PhD, but
  I particularly wish to thank Nick Barton for his guidance and intuition, and for
  encouraging me to take the time to look beyond the immediate topic of my PhD to
  understand the broader context. I am also especially grateful to David Field his
  bottomless patience, invaluable advice on experimental design, analysis and scientific
  writing, and for tireless work on the population surveys and genomic work without
  most of my thesis could not have happened. \r\n\r\nIt has been a pleasure to work
  with the combined strengths of the groups at The John Innes Centre, University of
  Toulouse and IST Austria. Thanks to Enrico Coen and his group for hosting me in
  Norwich in 2011 and especially for setting up the tag experiment. \r\n\r\nI thank
  David Field, Desmond Bradley and Maria Clara Melo-Hurtado for organising field collections,
  as well as Monique Burrus and Christophe Andalo and a large number of volunteers
  for their e ff orts helping with the field work. Furthermore I thank Coline Jaworski
  for providing seeds and for her input into the design of the experimental arrays,
  and Matthew Couchman for maintaining the database of. \r\n\r\nIn addition to those
  mentioned above, I am grateful to Melinda Pickup, Spencer Barrett, and four anonymous
  reviewers for their insightful comments on sections of this manuscript. I also thank
  Jana Porsche for her e ff orts in tracking down the more obscure references for
  chapter 5, and Jon Bollback for his advice about the analysis. \r\n\r\nI am indebted
  to Jon Ågren for his patience whilst I finished this thesis, and to Sylvia Cremer
  and Magnus Nordborg for taking the time to read and evaluate the thesis given a
  shorter deadline than was fair. \r\n\r\nA very positive aspect of my PhD has been
  the supportive atmosphere of IST. In particular, I have come to appreciate the enormous
  support from our group assistants Nicole Hotzy, Julia Asimakis, Christine Ostermann
  and Jerneja Beslagic. I also thank Christian Chaloupka and Stefan Hipfinger for
  their enthusiasm and readiness to help where possible in setting up our greenhouse
  and experiments. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
citation:
  ama: Ellis T. The role of pollinator-mediated selection in the maintenance of a
    flower color polymorphism in an Antirrhinum majus hybrid zone. 2016. doi:<a href="https://doi.org/10.15479/AT:ISTA:TH_526
    ">10.15479/AT:ISTA:TH_526 </a>
  apa: Ellis, T. (2016). <i>The role of pollinator-mediated selection in the maintenance
    of a flower color polymorphism in an Antirrhinum majus hybrid zone</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:TH_526
    ">https://doi.org/10.15479/AT:ISTA:TH_526 </a>
  chicago: Ellis, Thomas. “The Role of Pollinator-Mediated Selection in the Maintenance
    of a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone.” Institute
    of Science and Technology Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:TH_526
    ">https://doi.org/10.15479/AT:ISTA:TH_526 </a>.
  ieee: T. Ellis, “The role of pollinator-mediated selection in the maintenance of
    a flower color polymorphism in an Antirrhinum majus hybrid zone,” Institute of
    Science and Technology Austria, 2016.
  ista: Ellis T. 2016. The role of pollinator-mediated selection in the maintenance
    of a flower color polymorphism in an Antirrhinum majus hybrid zone. Institute
    of Science and Technology Austria.
  mla: Ellis, Thomas. <i>The Role of Pollinator-Mediated Selection in the Maintenance
    of a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone</i>. Institute
    of Science and Technology Austria, 2016, doi:<a href="https://doi.org/10.15479/AT:ISTA:TH_526
    ">10.15479/AT:ISTA:TH_526 </a>.
  short: T. Ellis, The Role of Pollinator-Mediated Selection in the Maintenance of
    a Flower Color Polymorphism in an Antirrhinum Majus Hybrid Zone, Institute of
    Science and Technology Austria, 2016.
corr_author: '1'
date_created: 2018-12-11T11:51:47Z
date_published: 2016-02-18T00:00:00Z
date_updated: 2026-07-30T14:56:14Z
day: '18'
ddc:
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degree_awarded: PhD
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- _id: GradSch
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status: public
supervisor:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: The role of pollinator-mediated selection in the maintenance of a flower color
  polymorphism in an Antirrhinum majus hybrid zone
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2016'
...
---
_id: '5553'
abstract:
- lang: eng
  text: "Genotypic, phenotypic and demographic data for 2128 wild snapdragons and
    1127 open-pollinated progeny from a natural hybrid zone, collected as part of
    Tom Ellis' PhD thesis (submitted) February 2016).\r\n\r\nTissue samples were sent
    to LGC Genomics in Berlin for DNA extraction, and genotyping at 70 SNP markers
    by KASPR genotyping. 29 of these SNPs failed to amplify reliably, and have been
    removed from this dataset.\r\n\r\nOther data were retreived from an online database
    of this population at www.antspec.org."
article_processing_charge: No
author:
- first_name: David
  full_name: Field, David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
  orcid: 0000-0002-4014-8478
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
citation:
  ama: Field D, Ellis T. Inference of mating patterns among wild snapdragons in a
    natural hybrid zone in 2012. 2016. doi:<a href="https://doi.org/10.15479/AT:ISTA:37">10.15479/AT:ISTA:37</a>
  apa: Field, D., &#38; Ellis, T. (2016). Inference of mating patterns among wild
    snapdragons in a natural hybrid zone in 2012. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/AT:ISTA:37">https://doi.org/10.15479/AT:ISTA:37</a>
  chicago: Field, David, and Thomas Ellis. “Inference of Mating Patterns among Wild
    Snapdragons in a Natural Hybrid Zone in 2012.” Institute of Science and Technology
    Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:37">https://doi.org/10.15479/AT:ISTA:37</a>.
  ieee: D. Field and T. Ellis, “Inference of mating patterns among wild snapdragons
    in a natural hybrid zone in 2012.” Institute of Science and Technology Austria,
    2016.
  ista: Field D, Ellis T. 2016. Inference of mating patterns among wild snapdragons
    in a natural hybrid zone in 2012, Institute of Science and Technology Austria,
    <a href="https://doi.org/10.15479/AT:ISTA:37">10.15479/AT:ISTA:37</a>.
  mla: Field, David, and Thomas Ellis. <i>Inference of Mating Patterns among Wild
    Snapdragons in a Natural Hybrid Zone in 2012</i>. Institute of Science and Technology
    Austria, 2016, doi:<a href="https://doi.org/10.15479/AT:ISTA:37">10.15479/AT:ISTA:37</a>.
  short: D. Field, T. Ellis, (2016).
contributor:
- contributor_type: project_manager
  first_name: Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
datarep_id: '37'
date_created: 2018-12-12T12:31:30Z
date_published: 2016-02-19T00:00:00Z
date_updated: 2026-07-30T14:56:13Z
day: '19'
ddc:
- '576'
department:
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doi: 10.15479/AT:ISTA:37
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  date_updated: 2020-07-14T12:47:01Z
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  file_size: 132808
  relation: main_file
file_date_updated: 2020-07-14T12:47:01Z
has_accepted_license: '1'
keyword:
- paternity assignment
- pedigree
- matting patterns
- assortative mating
- Antirrhinum majus
- frequency-dependent selection
- plant-pollinator interaction
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
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title: Inference of mating patterns among wild snapdragons in a natural hybrid zone
  in 2012
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abstract:
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  text: "Data from array experiments investigating pollinator behaviour on snapdragons
    in controlled conditions, and their effect on plant mating. Data were collected
    as part of Tom Ellis' PhD thesis , submitted February 2016.\r\n\r\nWe placed a
    total of 36 plants in a grid inside a closed organza tent, with a single hive
    of commercially bred bumblebees (Bombus hortorum). We used only the yellow-flowered
    Antirrhinum majus striatum and the magenta-flowered Antirrhinum majus pseudomajus,
    at ratios of 6:36, 12:24, 18:18, 24:12 and 30:6.\r\n\r\nAfter 24 hours to learn
    how to deal with snapdragons, I observed pollinators foraging on plants, and recorded
    the transitions between plants. Thereafter seeds on plants were allowed to develops.
    A sample of these were grown to maturity when their flower colour could be determined,
    and they were scored as yellow, magenta, or hybrid."
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
citation:
  ama: Ellis T. Data on pollinator observations and offpsring phenotypes. 2016. doi:<a
    href="https://doi.org/10.15479/AT:ISTA:35">10.15479/AT:ISTA:35</a>
  apa: Ellis, T. (2016). Data on pollinator observations and offpsring phenotypes.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:35">https://doi.org/10.15479/AT:ISTA:35</a>
  chicago: Ellis, Thomas. “Data on Pollinator Observations and Offpsring Phenotypes.”
    Institute of Science and Technology Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:35">https://doi.org/10.15479/AT:ISTA:35</a>.
  ieee: T. Ellis, “Data on pollinator observations and offpsring phenotypes.” Institute
    of Science and Technology Austria, 2016.
  ista: Ellis T. 2016. Data on pollinator observations and offpsring phenotypes, Institute
    of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:35">10.15479/AT:ISTA:35</a>.
  mla: Ellis, Thomas. <i>Data on Pollinator Observations and Offpsring Phenotypes</i>.
    Institute of Science and Technology Austria, 2016, doi:<a href="https://doi.org/10.15479/AT:ISTA:35">10.15479/AT:ISTA:35</a>.
  short: T. Ellis, (2016).
contributor:
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  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
- first_name: Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
datarep_id: '35'
date_created: 2018-12-12T12:31:29Z
date_published: 2016-02-19T00:00:00Z
date_updated: 2026-07-30T14:56:13Z
day: '19'
department:
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doi: 10.15479/AT:ISTA:35
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title: Data on pollinator observations and offpsring phenotypes
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...
---
_id: '5552'
abstract:
- lang: eng
  text: "Data on pollinator visitation to wild snapdragons in a natural hybrid zone,
    collected as part of Tom Ellis' PhD thesis (submitted February 2016).\r\n\r\nSnapdragon
    flowers have a mouth-like structure which pollinators must open to access nectar.
    We placed 5mm cellophane tags in these mouths, which are held in place by the
    pressure of the flower until a pollinator visits. When she opens the flower, the
    tag drops out, and one can infer a visit. We surveyed plants over multiple days
    in 2010, 2011 and 2012.\r\n\r\nAlso included are data on phenotypic and demographic
    variables which may be explanatory variables for pollinator visitation."
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Ellis, Thomas
  id: 3153D6D4-F248-11E8-B48F-1D18A9856A87
  last_name: Ellis
  orcid: 0000-0002-8511-0254
citation:
  ama: Ellis T. Pollinator visitation data for wild Antirrhinum majus plants, with
    phenotypic and frequency data. 2016. doi:<a href="https://doi.org/10.15479/AT:ISTA:36">10.15479/AT:ISTA:36</a>
  apa: Ellis, T. (2016). Pollinator visitation data for wild Antirrhinum majus plants,
    with phenotypic and frequency data. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT:ISTA:36">https://doi.org/10.15479/AT:ISTA:36</a>
  chicago: Ellis, Thomas. “Pollinator Visitation Data for Wild Antirrhinum Majus Plants,
    with Phenotypic and Frequency Data.” Institute of Science and Technology Austria,
    2016. <a href="https://doi.org/10.15479/AT:ISTA:36">https://doi.org/10.15479/AT:ISTA:36</a>.
  ieee: T. Ellis, “Pollinator visitation data for wild Antirrhinum majus plants, with
    phenotypic and frequency data.” Institute of Science and Technology Austria, 2016.
  ista: Ellis T. 2016. Pollinator visitation data for wild Antirrhinum majus plants,
    with phenotypic and frequency data., Institute of Science and Technology Austria,
    <a href="https://doi.org/10.15479/AT:ISTA:36">10.15479/AT:ISTA:36</a>.
  mla: Ellis, Thomas. <i>Pollinator Visitation Data for Wild Antirrhinum Majus Plants,
    with Phenotypic and Frequency Data.</i> Institute of Science and Technology Austria,
    2016, doi:<a href="https://doi.org/10.15479/AT:ISTA:36">10.15479/AT:ISTA:36</a>.
  short: T. Ellis, (2016).
contributor:
- first_name: David
  id: 419049E2-F248-11E8-B48F-1D18A9856A87
  last_name: Field
- first_name: Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
datarep_id: '36'
date_created: 2018-12-12T12:31:30Z
date_published: 2016-02-19T00:00:00Z
date_updated: 2026-07-30T14:56:13Z
day: '19'
department:
- _id: NiBa
doi: 10.15479/AT:ISTA:36
file:
- access_level: open_access
  checksum: cbc61b523d4d475a04a737d50dc470ef
  content_type: application/zip
  creator: system
  date_created: 2018-12-12T13:03:07Z
  date_updated: 2020-07-14T12:47:01Z
  file_id: '5625'
  file_name: IST-2016-36-v1+1_tag_assay_archive.zip
  file_size: 44905
  relation: main_file
file_date_updated: 2020-07-14T12:47:01Z
has_accepted_license: '1'
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '1398'
    relation: dissertation_contains
    status: public
status: public
title: Pollinator visitation data for wild Antirrhinum majus plants, with phenotypic
  and frequency data.
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '1430'
abstract:
- lang: eng
  text: Evolutionary algorithms (EAs) form a popular optimisation paradigm inspired
    by natural evolution. In recent years the field of evolutionary computation has
    developed a rigorous analytical theory to analyse their runtime on many illustrative
    problems. Here we apply this theory to a simple model of natural evolution. In
    the Strong Selection Weak Mutation (SSWM) evolutionary regime the time between
    occurrence of new mutations is much longer than the time it takes for a new beneficial
    mutation to take over the population. In this situation, the population only contains
    copies of one genotype and evolution can be modelled as a (1+1)-type process where
    the probability of accepting a new genotype (improvements or worsenings) depends
    on the change in fitness. We present an initial runtime analysis of SSWM, quantifying
    its performance for various parameters and investigating differences to the (1+1)
    EA. We show that SSWM can have a moderate advantage over the (1+1) EA at crossing
    fitness valleys and study an example where SSWM outperforms the (1+1) EA by taking
    advantage of information on the fitness gradient.
article_processing_charge: No
arxiv: 1
author:
- first_name: Tiago
  full_name: Paixao, Tiago
  id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
  last_name: Paixao
  orcid: 0000-0003-2361-3953
- first_name: Dirk
  full_name: Sudholt, Dirk
  last_name: Sudholt
- first_name: Jorge
  full_name: Heredia, Jorge
  last_name: Heredia
- first_name: Barbora
  full_name: Trubenova, Barbora
  id: 42302D54-F248-11E8-B48F-1D18A9856A87
  last_name: Trubenova
  orcid: 0000-0002-6873-2967
citation:
  ama: 'Paixao T, Sudholt D, Heredia J, Trubenova B. First steps towards a runtime
    comparison of natural and artificial evolution. In: <i>Proceedings of the 2015
    Annual Conference on Genetic and Evolutionary Computation</i>. ACM; 2015:1455-1462.
    doi:<a href="https://doi.org/10.1145/2739480.2754758">10.1145/2739480.2754758</a>'
  apa: 'Paixao, T., Sudholt, D., Heredia, J., &#38; Trubenova, B. (2015). First steps
    towards a runtime comparison of natural and artificial evolution. In <i>Proceedings
    of the 2015 Annual Conference on Genetic and Evolutionary Computation</i> (pp.
    1455–1462). Madrid, Spain: ACM. <a href="https://doi.org/10.1145/2739480.2754758">https://doi.org/10.1145/2739480.2754758</a>'
  chicago: Paixao, Tiago, Dirk Sudholt, Jorge Heredia, and Barbora Trubenova. “First
    Steps towards a Runtime Comparison of Natural and Artificial Evolution.” In <i>Proceedings
    of the 2015 Annual Conference on Genetic and Evolutionary Computation</i>, 1455–62.
    ACM, 2015. <a href="https://doi.org/10.1145/2739480.2754758">https://doi.org/10.1145/2739480.2754758</a>.
  ieee: T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards
    a runtime comparison of natural and artificial evolution,” in <i>Proceedings of
    the 2015 Annual Conference on Genetic and Evolutionary Computation</i>, Madrid,
    Spain, 2015, pp. 1455–1462.
  ista: 'Paixao T, Sudholt D, Heredia J, Trubenova B. 2015. First steps towards a
    runtime comparison of natural and artificial evolution. Proceedings of the 2015
    Annual Conference on Genetic and Evolutionary Computation. GECCO: Genetic and
    evolutionary computation conference, 1455–1462.'
  mla: Paixao, Tiago, et al. “First Steps towards a Runtime Comparison of Natural
    and Artificial Evolution.” <i>Proceedings of the 2015 Annual Conference on Genetic
    and Evolutionary Computation</i>, ACM, 2015, pp. 1455–62, doi:<a href="https://doi.org/10.1145/2739480.2754758">10.1145/2739480.2754758</a>.
  short: T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the
    2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp.
    1455–1462.
conference:
  end_date: 2015-07-15
  location: Madrid, Spain
  name: 'GECCO: Genetic and evolutionary computation conference'
  start_date: 2015-07-11
date_created: 2018-12-11T11:51:58Z
date_published: 2015-07-11T00:00:00Z
date_updated: 2025-09-23T08:50:33Z
day: '11'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1145/2739480.2754758
ec_funded: 1
external_id:
  arxiv:
  - '1504.06260'
  isi:
  - '000358795700182'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1504.06260
month: '07'
oa: 1
oa_version: Preprint
page: 1455 - 1462
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618091'
  name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: Proceedings of the 2015 Annual Conference on Genetic and Evolutionary
  Computation
publication_status: published
publisher: ACM
publist_id: '5768'
quality_controlled: '1'
scopus_import: '1'
status: public
title: First steps towards a runtime comparison of natural and artificial evolution
type: conference
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
year: '2015'
...
---
_id: '1519'
abstract:
- lang: eng
  text: Evolutionary biologists have an array of powerful theoretical techniques that
    can accurately predict changes in the genetic composition of populations. Changes
    in gene frequencies and genetic associations between loci can be tracked as they
    respond to a wide variety of evolutionary forces. However, it is often less clear
    how to decompose these various forces into components that accurately reflect
    the underlying biology. Here, we present several issues that arise in the definition
    and interpretation of selection and selection coefficients, focusing on insights
    gained through the examination of selection coefficients in multilocus notation.
    Using this notation, we discuss how its flexibility-which allows different biological
    units to be identified as targets of selection-is reflected in the interpretation
    of the coefficients that the notation generates. In many situations, it can be
    difficult to agree on whether loci can be considered to be under &quot;direct&quot;
    versus &quot;indirect&quot; selection, or to quantify this selection. We present
    arguments for what the terms direct and indirect selection might best encompass,
    considering a range of issues, from viability and sexual selection to kin selection.
    We show how multilocus notation can discriminate between direct and indirect selection,
    and describe when it can do so.
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Maria
  full_name: Servedio, Maria
  last_name: Servedio
citation:
  ama: Barton NH, Servedio M. The interpretation of selection coefficients. <i>Evolution</i>.
    2015;69(5):1101-1112. doi:<a href="https://doi.org/10.1111/evo.12641">10.1111/evo.12641</a>
  apa: Barton, N. H., &#38; Servedio, M. (2015). The interpretation of selection coefficients.
    <i>Evolution</i>. Wiley. <a href="https://doi.org/10.1111/evo.12641">https://doi.org/10.1111/evo.12641</a>
  chicago: Barton, Nicholas H, and Maria Servedio. “The Interpretation of Selection
    Coefficients.” <i>Evolution</i>. Wiley, 2015. <a href="https://doi.org/10.1111/evo.12641">https://doi.org/10.1111/evo.12641</a>.
  ieee: N. H. Barton and M. Servedio, “The interpretation of selection coefficients,”
    <i>Evolution</i>, vol. 69, no. 5. Wiley, pp. 1101–1112, 2015.
  ista: Barton NH, Servedio M. 2015. The interpretation of selection coefficients.
    Evolution. 69(5), 1101–1112.
  mla: Barton, Nicholas H., and Maria Servedio. “The Interpretation of Selection Coefficients.”
    <i>Evolution</i>, vol. 69, no. 5, Wiley, 2015, pp. 1101–12, doi:<a href="https://doi.org/10.1111/evo.12641">10.1111/evo.12641</a>.
  short: N.H. Barton, M. Servedio, Evolution 69 (2015) 1101–1112.
corr_author: '1'
date_created: 2018-12-11T11:52:29Z
date_published: 2015-03-19T00:00:00Z
date_updated: 2025-09-23T13:53:01Z
day: '19'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/evo.12641
ec_funded: 1
external_id:
  isi:
  - '000354561600001'
file:
- access_level: open_access
  checksum: fd8d23f476bc194419929b72ca265c02
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:34Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4822'
  file_name: IST-2016-560-v1+1_Interpreting_ML_coefficients_11.2.15_App.pdf
  file_size: 188872
  relation: main_file
- access_level: open_access
  checksum: b774911e70044641d556e258efcb52ef
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:35Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4823'
  file_name: IST-2016-560-v1+2_Interpreting_ML_coefficients_11.2.15_mainText.pdf
  file_size: 577415
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        69'
isi: 1
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1101 - 1112
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Evolution
publication_status: published
publisher: Wiley
publist_id: '5656'
pubrep_id: '560'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The interpretation of selection coefficients
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 69
year: '2015'
...
---
_id: '1681'
abstract:
- lang: eng
  text: In many social situations, individuals endeavor to find the single best possible
    partner, but are constrained to evaluate the candidates in sequence. Examples
    include the search for mates, economic partnerships, or any other long-term ties
    where the choice to interact involves two parties. Surprisingly, however, previous
    theoretical work on mutual choice problems focuses on finding equilibrium solutions,
    while ignoring the evolutionary dynamics of decisions. Empirically, this may be
    of high importance, as some equilibrium solutions can never be reached unless
    the population undergoes radical changes and a sufficient number of individuals
    change their decisions simultaneously. To address this question, we apply a mutual
    choice sequential search problem in an evolutionary game-theoretical model that
    allows one to find solutions that are favored by evolution. As an example, we
    study the influence of sequential search on the evolutionary dynamics of cooperation.
    For this, we focus on the classic snowdrift game and the prisoner’s dilemma game.
article_processing_charge: No
article_type: original
author:
- first_name: Tadeas
  full_name: Priklopil, Tadeas
  id: 3C869AA0-F248-11E8-B48F-1D18A9856A87
  last_name: Priklopil
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
citation:
  ama: Priklopil T, Chatterjee K. Evolution of decisions in population games with
    sequentially searching individuals. <i>Games</i>. 2015;6(4):413-437. doi:<a href="https://doi.org/10.3390/g6040413">10.3390/g6040413</a>
  apa: Priklopil, T., &#38; Chatterjee, K. (2015). Evolution of decisions in population
    games with sequentially searching individuals. <i>Games</i>. MDPI. <a href="https://doi.org/10.3390/g6040413">https://doi.org/10.3390/g6040413</a>
  chicago: Priklopil, Tadeas, and Krishnendu Chatterjee. “Evolution of Decisions in
    Population Games with Sequentially Searching Individuals.” <i>Games</i>. MDPI,
    2015. <a href="https://doi.org/10.3390/g6040413">https://doi.org/10.3390/g6040413</a>.
  ieee: T. Priklopil and K. Chatterjee, “Evolution of decisions in population games
    with sequentially searching individuals,” <i>Games</i>, vol. 6, no. 4. MDPI, pp.
    413–437, 2015.
  ista: Priklopil T, Chatterjee K. 2015. Evolution of decisions in population games
    with sequentially searching individuals. Games. 6(4), 413–437.
  mla: Priklopil, Tadeas, and Krishnendu Chatterjee. “Evolution of Decisions in Population
    Games with Sequentially Searching Individuals.” <i>Games</i>, vol. 6, no. 4, MDPI,
    2015, pp. 413–37, doi:<a href="https://doi.org/10.3390/g6040413">10.3390/g6040413</a>.
  short: T. Priklopil, K. Chatterjee, Games 6 (2015) 413–437.
corr_author: '1'
date_created: 2018-12-11T11:53:26Z
date_published: 2015-09-29T00:00:00Z
date_updated: 2025-04-15T06:50:21Z
day: '29'
ddc:
- '000'
department:
- _id: NiBa
- _id: KrCh
doi: 10.3390/g6040413
ec_funded: 1
file:
- access_level: open_access
  checksum: 912e1acbaf201100f447a43e4d5958bd
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:41Z
  date_updated: 2020-07-14T12:45:12Z
  file_id: '4959'
  file_name: IST-2016-448-v1+1_games-06-00413.pdf
  file_size: 518832
  relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: '         6'
issue: '4'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 413 - 437
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication: Games
publication_identifier:
  eissn:
  - 2073-4336
publication_status: published
publisher: MDPI
publist_id: '5467'
pubrep_id: '448'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolution of decisions in population games with sequentially searching individuals
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2015'
...
---
_id: '1699'
abstract:
- lang: eng
  text: By hybridization and backcrossing, alleles can surmount species boundaries
    and be incorporated into the genome of a related species. This introgression of
    genes is of particular evolutionary relevance if it involves the transfer of adaptations
    between populations. However, any beneficial allele will typically be associated
    with other alien alleles that are often deleterious and hamper the introgression
    process. In order to describe the introgression of an adaptive allele, we set
    up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious
    alleles. Based on the theory of reducible multitype branching processes, we derive
    a recursive expression for the establishment probability of the beneficial allele
    after a single hybridization event. We furthermore study the probability that
    slightly deleterious alleles hitchhike to fixation. The key to the analysis is
    a split of the process into a stochastic phase in which the advantageous alleles
    establishes and a deterministic phase in which it sweeps to fixation. We thereafter
    apply the theory to a set of biologically relevant scenarios such as introgression
    in the presence of many unlinked or few closely linked deleterious alleles. A
    comparison to computer simulations shows that the approximations work well over
    a large parameter range.
acknowledgement: This work was made possible with financial support by the Vienna
  Science and Technology Fund (WWTF), by the Deutsche Forschungsgemeinschaft (DFG),
  Research Unit 1078 Natural selection in structured populations, by the Austrian
  Science Fund (FWF) via funding for the Vienna Graduate School for Population Genetics,
  and by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with
  the Austrian Commission for UNESCO and the Austrian Academy of Sciences with financial
  support from the Federal Ministry for Science and Research Austria).
article_processing_charge: No
author:
- first_name: Hildegard
  full_name: Uecker, Hildegard
  id: 2DB8F68A-F248-11E8-B48F-1D18A9856A87
  last_name: Uecker
  orcid: 0000-0001-9435-2813
- first_name: Derek
  full_name: Setter, Derek
  last_name: Setter
- first_name: Joachim
  full_name: Hermisson, Joachim
  last_name: Hermisson
citation:
  ama: Uecker H, Setter D, Hermisson J. Adaptive gene introgression after secondary
    contact. <i>Journal of Mathematical Biology</i>. 2015;70(7):1523-1580. doi:<a
    href="https://doi.org/10.1007/s00285-014-0802-y">10.1007/s00285-014-0802-y</a>
  apa: Uecker, H., Setter, D., &#38; Hermisson, J. (2015). Adaptive gene introgression
    after secondary contact. <i>Journal of Mathematical Biology</i>. Springer. <a
    href="https://doi.org/10.1007/s00285-014-0802-y">https://doi.org/10.1007/s00285-014-0802-y</a>
  chicago: Uecker, Hildegard, Derek Setter, and Joachim Hermisson. “Adaptive Gene
    Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>.
    Springer, 2015. <a href="https://doi.org/10.1007/s00285-014-0802-y">https://doi.org/10.1007/s00285-014-0802-y</a>.
  ieee: H. Uecker, D. Setter, and J. Hermisson, “Adaptive gene introgression after
    secondary contact,” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7. Springer,
    pp. 1523–1580, 2015.
  ista: Uecker H, Setter D, Hermisson J. 2015. Adaptive gene introgression after secondary
    contact. Journal of Mathematical Biology. 70(7), 1523–1580.
  mla: Uecker, Hildegard, et al. “Adaptive Gene Introgression after Secondary Contact.”
    <i>Journal of Mathematical Biology</i>, vol. 70, no. 7, Springer, 2015, pp. 1523–80,
    doi:<a href="https://doi.org/10.1007/s00285-014-0802-y">10.1007/s00285-014-0802-y</a>.
  short: H. Uecker, D. Setter, J. Hermisson, Journal of Mathematical Biology 70 (2015)
    1523–1580.
corr_author: '1'
date_created: 2018-12-11T11:53:32Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2025-09-23T07:31:45Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1007/s00285-014-0802-y
external_id:
  isi:
  - '000354196800003'
file:
- access_level: open_access
  checksum: 00e3a67bda05d4cc165b3a48b41ef9ad
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:27Z
  date_updated: 2020-07-14T12:45:12Z
  file_id: '5079'
  file_name: IST-2016-458-v1+1_s00285-014-0802-y.pdf
  file_size: 1321527
  relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: '        70'
isi: 1
issue: '7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1523 - 1580
project:
- _id: 25B67606-B435-11E9-9278-68D0E5697425
  name: Evolutionary rescue
publication: Journal of Mathematical Biology
publication_status: published
publisher: Springer
publist_id: '5442'
pubrep_id: '458'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adaptive gene introgression after secondary contact
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 70
year: '2015'
...
---
_id: '1703'
abstract:
- lang: eng
  text: Vegetation clearing and land-use change have depleted many natural plant communities
    to the point where restoration is required. A major impediment to the success
    of rebuilding complex vegetation communities is having regular access to sufficient
    quantities of high-quality seed. Seed-production areas (SPAs) can help generate
    this seed, but these must be underpinned by a broad genetic base to maximise the
    evolutionary potential of restored populations. However, genetic bottlenecks can
    occur at the collection, establishment and production stages in SPAs, requiring
    genetic evaluation. This is especially relevant for species that may take many
    years before a return on SPA investment is realised. Two recently established
    yellow box (Eucalyptus melliodora A.Cunn. ex Schauer, Myrtaceae) SPAs were evaluated
    to determine whether genetic bottlenecks had occurred between seed collection
    and SPA establishment. No evidence was found to suggest that a significant loss
    of genetic diversity had occurred at this stage, although there was a significant
    difference in diversity between the two SPAs. Complex population genetic structure
    was also observed in the seed used to source the SPAs, with up to eight groups
    identified. Plant survival in the SPAs was influenced by seed collection location
    but not by SPA location and was not associated with genetic diversity. There were
    also no associations between genetic diversity and plant growth. These data highlighted
    the importance of chance events when establishing SPAs and indicated that the
    two yellow box SPAs are likely to provide genetically diverse seed sources for
    future restoration projects, especially by pooling seed from both SPAs.
article_processing_charge: No
author:
- first_name: Linda
  full_name: Broadhurst, Linda
  last_name: Broadhurst
- first_name: Graham
  full_name: Fifield, Graham
  last_name: Fifield
- first_name: Bindi
  full_name: Vanzella, Bindi
  last_name: Vanzella
- first_name: Melinda
  full_name: Pickup, Melinda
  id: 2C78037E-F248-11E8-B48F-1D18A9856A87
  last_name: Pickup
  orcid: 0000-0001-6118-0541
citation:
  ama: Broadhurst L, Fifield G, Vanzella B, Pickup M. An evaluation of the genetic
    structure of seed sources and the maintenance of genetic diversity during establishment
    of two yellow box (Eucalyptus melliodora) seed-production areas. <i>Australian
    Journal of Botany</i>. 2015;63(5):455-466. doi:<a href="https://doi.org/10.1071/BT15023">10.1071/BT15023</a>
  apa: Broadhurst, L., Fifield, G., Vanzella, B., &#38; Pickup, M. (2015). An evaluation
    of the genetic structure of seed sources and the maintenance of genetic diversity
    during establishment of two yellow box (Eucalyptus melliodora) seed-production
    areas. <i>Australian Journal of Botany</i>. CSIRO. <a href="https://doi.org/10.1071/BT15023">https://doi.org/10.1071/BT15023</a>
  chicago: Broadhurst, Linda, Graham Fifield, Bindi Vanzella, and Melinda Pickup.
    “An Evaluation of the Genetic Structure of Seed Sources and the Maintenance of
    Genetic Diversity during Establishment of Two Yellow Box (Eucalyptus Melliodora)
    Seed-Production Areas.” <i>Australian Journal of Botany</i>. CSIRO, 2015. <a href="https://doi.org/10.1071/BT15023">https://doi.org/10.1071/BT15023</a>.
  ieee: L. Broadhurst, G. Fifield, B. Vanzella, and M. Pickup, “An evaluation of the
    genetic structure of seed sources and the maintenance of genetic diversity during
    establishment of two yellow box (Eucalyptus melliodora) seed-production areas,”
    <i>Australian Journal of Botany</i>, vol. 63, no. 5. CSIRO, pp. 455–466, 2015.
  ista: Broadhurst L, Fifield G, Vanzella B, Pickup M. 2015. An evaluation of the
    genetic structure of seed sources and the maintenance of genetic diversity during
    establishment of two yellow box (Eucalyptus melliodora) seed-production areas.
    Australian Journal of Botany. 63(5), 455–466.
  mla: Broadhurst, Linda, et al. “An Evaluation of the Genetic Structure of Seed Sources
    and the Maintenance of Genetic Diversity during Establishment of Two Yellow Box
    (Eucalyptus Melliodora) Seed-Production Areas.” <i>Australian Journal of Botany</i>,
    vol. 63, no. 5, CSIRO, 2015, pp. 455–66, doi:<a href="https://doi.org/10.1071/BT15023">10.1071/BT15023</a>.
  short: L. Broadhurst, G. Fifield, B. Vanzella, M. Pickup, Australian Journal of
    Botany 63 (2015) 455–466.
date_created: 2018-12-11T11:53:34Z
date_published: 2015-05-26T00:00:00Z
date_updated: 2025-09-23T07:51:07Z
day: '26'
department:
- _id: NiBa
doi: 10.1071/BT15023
external_id:
  isi:
  - '000363276500009'
intvolume: '        63'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 455 - 466
publication: Australian Journal of Botany
publication_status: published
publisher: CSIRO
publist_id: '5434'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An evaluation of the genetic structure of seed sources and the maintenance
  of genetic diversity during establishment of two yellow box (Eucalyptus melliodora)
  seed-production areas
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 63
year: '2015'
...
---
_id: '1850'
abstract:
- lang: eng
  text: 'Entomopathogenic fungi are potent biocontrol agents that are widely used
    against insect pests, many of which are social insects. Nevertheless, theoretical
    investigations of their particular life history are scarce. We develop a model
    that takes into account the main distinguishing features between traditionally
    studied diseases and obligate killing pathogens, like the (biocontrol-relevant)
    insect-pathogenic fungi Metarhizium and Beauveria. First, obligate killing entomopathogenic
    fungi produce new infectious particles (conidiospores) only after host death and
    not yet on the living host. Second, the killing rates of entomopathogenic fungi
    depend strongly on the initial exposure dosage, thus we explicitly consider the
    pathogen load of individual hosts. Further, we make the model applicable not only
    to solitary host species, but also to group living species by incorporating social
    interactions between hosts, like the collective disease defences of insect societies.
    Our results identify the optimal killing rate for the pathogen that minimises
    its invasion threshold. Furthermore, we find that the rate of contact between
    hosts has an ambivalent effect: dense interaction networks between individuals
    are considered to facilitate disease outbreaks because of increased pathogen transmission.
    In social insects, this is compensated by their collective disease defences, i.e.,
    social immunity. For the type of pathogens considered here, we show that even
    without social immunity, high contact rates between live individuals dilute the
    pathogen in the host colony and hence can reduce individual pathogen loads below
    disease-causing levels.'
article_processing_charge: No
author:
- first_name: Sebastian
  full_name: Novak, Sebastian
  id: 461468AE-F248-11E8-B48F-1D18A9856A87
  last_name: Novak
  orcid: 0000-0002-2519-824X
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
citation:
  ama: 'Novak S, Cremer S. Fungal disease dynamics in insect societies: Optimal killing
    rates and the ambivalent effect of high social interaction rates. <i>Journal of
    Theoretical Biology</i>. 2015;372(5):54-64. doi:<a href="https://doi.org/10.1016/j.jtbi.2015.02.018">10.1016/j.jtbi.2015.02.018</a>'
  apa: 'Novak, S., &#38; Cremer, S. (2015). Fungal disease dynamics in insect societies:
    Optimal killing rates and the ambivalent effect of high social interaction rates.
    <i>Journal of Theoretical Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jtbi.2015.02.018">https://doi.org/10.1016/j.jtbi.2015.02.018</a>'
  chicago: 'Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect
    Societies: Optimal Killing Rates and the Ambivalent Effect of High Social Interaction
    Rates.” <i>Journal of Theoretical Biology</i>. Elsevier, 2015. <a href="https://doi.org/10.1016/j.jtbi.2015.02.018">https://doi.org/10.1016/j.jtbi.2015.02.018</a>.'
  ieee: 'S. Novak and S. Cremer, “Fungal disease dynamics in insect societies: Optimal
    killing rates and the ambivalent effect of high social interaction rates,” <i>Journal
    of Theoretical Biology</i>, vol. 372, no. 5. Elsevier, pp. 54–64, 2015.'
  ista: 'Novak S, Cremer S. 2015. Fungal disease dynamics in insect societies: Optimal
    killing rates and the ambivalent effect of high social interaction rates. Journal
    of Theoretical Biology. 372(5), 54–64.'
  mla: 'Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect Societies:
    Optimal Killing Rates and the Ambivalent Effect of High Social Interaction Rates.”
    <i>Journal of Theoretical Biology</i>, vol. 372, no. 5, Elsevier, 2015, pp. 54–64,
    doi:<a href="https://doi.org/10.1016/j.jtbi.2015.02.018">10.1016/j.jtbi.2015.02.018</a>.'
  short: S. Novak, S. Cremer, Journal of Theoretical Biology 372 (2015) 54–64.
corr_author: '1'
date_created: 2018-12-11T11:54:21Z
date_published: 2015-05-07T00:00:00Z
date_updated: 2025-09-23T08:54:35Z
day: '07'
ddc:
- '576'
department:
- _id: NiBa
- _id: SyCr
doi: 10.1016/j.jtbi.2015.02.018
ec_funded: 1
external_id:
  isi:
  - '000353311700006'
file:
- access_level: open_access
  checksum: 3c0dcacc900bc45cc65a453dfda4ca43
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:18:07Z
  date_updated: 2020-07-14T12:45:19Z
  file_id: '5326'
  file_name: IST-2015-329-v1+1_manuscript.pdf
  file_size: 1546914
  relation: main_file
file_date_updated: 2020-07-14T12:45:19Z
has_accepted_license: '1'
intvolume: '       372'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 54 - 64
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
- _id: 25DC711C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '243071'
  name: 'Social Vaccination in Ant Colonies: from Individual Mechanisms to Society
    Effects'
publication: Journal of Theoretical Biology
publication_status: published
publisher: Elsevier
publist_id: '5251'
pubrep_id: '329'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Fungal disease dynamics in insect societies: Optimal killing rates and the
  ambivalent effect of high social interaction rates'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 372
year: '2015'
...
---
_id: '1851'
abstract:
- lang: eng
  text: We consider mating strategies for females who search for males sequentially
    during a season of limited length. We show that the best strategy rejects a given
    male type if encountered before a time-threshold but accepts him after. For frequency-independent
    benefits, we obtain the optimal time-thresholds explicitly for both discrete and
    continuous distributions of males, and allow for mistakes being made in assessing
    the correct male type. When the benefits are indirect (genes for the offspring)
    and the population is under frequency-dependent ecological selection, the benefits
    depend on the mating strategy of other females as well. This case is particularly
    relevant to speciation models that seek to explore the stability of reproductive
    isolation by assortative mating under frequency-dependent ecological selection.
    We show that the indirect benefits are to be quantified by the reproductive values
    of couples, and describe how the evolutionarily stable time-thresholds can be
    found. We conclude with an example based on the Levene model, in which we analyze
    the evolutionarily stable assortative mating strategies and the strength of reproductive
    isolation provided by them.
article_processing_charge: No
article_type: original
author:
- first_name: Tadeas
  full_name: Priklopil, Tadeas
  id: 3C869AA0-F248-11E8-B48F-1D18A9856A87
  last_name: Priklopil
- first_name: Eva
  full_name: Kisdi, Eva
  last_name: Kisdi
- first_name: Mats
  full_name: Gyllenberg, Mats
  last_name: Gyllenberg
citation:
  ama: Priklopil T, Kisdi E, Gyllenberg M. Evolutionarily stable mating decisions
    for sequentially searching females and the stability of reproductive isolation
    by assortative mating. <i>Evolution</i>. 2015;69(4):1015-1026. doi:<a href="https://doi.org/10.1111/evo.12618">10.1111/evo.12618</a>
  apa: Priklopil, T., Kisdi, E., &#38; Gyllenberg, M. (2015). Evolutionarily stable
    mating decisions for sequentially searching females and the stability of reproductive
    isolation by assortative mating. <i>Evolution</i>. Wiley. <a href="https://doi.org/10.1111/evo.12618">https://doi.org/10.1111/evo.12618</a>
  chicago: Priklopil, Tadeas, Eva Kisdi, and Mats Gyllenberg. “Evolutionarily Stable
    Mating Decisions for Sequentially Searching Females and the Stability of Reproductive
    Isolation by Assortative Mating.” <i>Evolution</i>. Wiley, 2015. <a href="https://doi.org/10.1111/evo.12618">https://doi.org/10.1111/evo.12618</a>.
  ieee: T. Priklopil, E. Kisdi, and M. Gyllenberg, “Evolutionarily stable mating decisions
    for sequentially searching females and the stability of reproductive isolation
    by assortative mating,” <i>Evolution</i>, vol. 69, no. 4. Wiley, pp. 1015–1026,
    2015.
  ista: Priklopil T, Kisdi E, Gyllenberg M. 2015. Evolutionarily stable mating decisions
    for sequentially searching females and the stability of reproductive isolation
    by assortative mating. Evolution. 69(4), 1015–1026.
  mla: Priklopil, Tadeas, et al. “Evolutionarily Stable Mating Decisions for Sequentially
    Searching Females and the Stability of Reproductive Isolation by Assortative Mating.”
    <i>Evolution</i>, vol. 69, no. 4, Wiley, 2015, pp. 1015–26, doi:<a href="https://doi.org/10.1111/evo.12618">10.1111/evo.12618</a>.
  short: T. Priklopil, E. Kisdi, M. Gyllenberg, Evolution 69 (2015) 1015–1026.
corr_author: '1'
date_created: 2018-12-11T11:54:21Z
date_published: 2015-02-09T00:00:00Z
date_updated: 2025-09-22T14:27:30Z
day: '09'
ddc:
- '570'
department:
- _id: NiBa
- _id: KrCh
doi: 10.1111/evo.12618
ec_funded: 1
external_id:
  isi:
  - '000353236000014'
  pmid:
  - '25662095'
file:
- access_level: open_access
  checksum: 1e8be0b1d7598a78cd2623d8ee8e7798
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-15T09:05:34Z
  date_updated: 2020-07-14T12:45:19Z
  file_id: '7855'
  file_name: 2015_Evolution_Priklopil.pdf
  file_size: 967214
  relation: main_file
file_date_updated: 2020-07-14T12:45:19Z
has_accepted_license: '1'
intvolume: '        69'
isi: 1
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Submitted Version
page: 1015 - 1026
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Evolution
publication_identifier:
  eissn:
  - 1558-5646
  issn:
  - 0014-3820
publication_status: published
publisher: Wiley
publist_id: '5249'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionarily stable mating decisions for sequentially searching females and
  the stability of reproductive isolation by assortative mating
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 69
year: '2015'
...
---
_id: '1883'
abstract:
- lang: eng
  text: "We introduce a one-parametric family of tree growth models, in which branching
    probabilities decrease with branch age τ as τ-α. Depending on the exponent α,
    the scaling of tree depth with tree size n displays a transition between the logarithmic
    scaling of random trees and an algebraic growth. At the transition (α=1) tree
    depth grows as (logn)2. This anomalous scaling is in good agreement with the trend
    observed in evolution of biological species, thus providing a theoretical support
    for age-dependent speciation and associating it to the occurrence of a critical
    point.\r\n"
article_number: '022803'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Stephanie
  full_name: Keller-Schmidt, Stephanie
  last_name: Keller-Schmidt
- first_name: Murat
  full_name: Tugrul, Murat
  id: 37C323C6-F248-11E8-B48F-1D18A9856A87
  last_name: Tugrul
  orcid: 0000-0002-8523-0758
- first_name: Víctor
  full_name: Eguíluz, Víctor
  last_name: Eguíluz
- first_name: Emilio
  full_name: Hernandez Garcia, Emilio
  last_name: Hernandez Garcia
- first_name: Konstantin
  full_name: Klemm, Konstantin
  last_name: Klemm
citation:
  ama: Keller-Schmidt S, Tugrul M, Eguíluz V, Hernandez Garcia E, Klemm K. Anomalous
    scaling in an age-dependent branching model. <i>Physical Review E Statistical
    Nonlinear and Soft Matter Physics</i>. 2015;91(2). doi:<a href="https://doi.org/10.1103/PhysRevE.91.022803">10.1103/PhysRevE.91.022803</a>
  apa: Keller-Schmidt, S., Tugrul, M., Eguíluz, V., Hernandez Garcia, E., &#38; Klemm,
    K. (2015). Anomalous scaling in an age-dependent branching model. <i>Physical
    Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute
    of Physics. <a href="https://doi.org/10.1103/PhysRevE.91.022803">https://doi.org/10.1103/PhysRevE.91.022803</a>
  chicago: Keller-Schmidt, Stephanie, Murat Tugrul, Víctor Eguíluz, Emilio Hernandez
    Garcia, and Konstantin Klemm. “Anomalous Scaling in an Age-Dependent Branching
    Model.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>.
    American Institute of Physics, 2015. <a href="https://doi.org/10.1103/PhysRevE.91.022803">https://doi.org/10.1103/PhysRevE.91.022803</a>.
  ieee: S. Keller-Schmidt, M. Tugrul, V. Eguíluz, E. Hernandez Garcia, and K. Klemm,
    “Anomalous scaling in an age-dependent branching model,” <i>Physical Review E
    Statistical Nonlinear and Soft Matter Physics</i>, vol. 91, no. 2. American Institute
    of Physics, 2015.
  ista: Keller-Schmidt S, Tugrul M, Eguíluz V, Hernandez Garcia E, Klemm K. 2015.
    Anomalous scaling in an age-dependent branching model. Physical Review E Statistical
    Nonlinear and Soft Matter Physics. 91(2), 022803.
  mla: Keller-Schmidt, Stephanie, et al. “Anomalous Scaling in an Age-Dependent Branching
    Model.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>,
    vol. 91, no. 2, 022803, American Institute of Physics, 2015, doi:<a href="https://doi.org/10.1103/PhysRevE.91.022803">10.1103/PhysRevE.91.022803</a>.
  short: S. Keller-Schmidt, M. Tugrul, V. Eguíluz, E. Hernandez Garcia, K. Klemm,
    Physical Review E Statistical Nonlinear and Soft Matter Physics 91 (2015).
date_created: 2018-12-11T11:54:31Z
date_published: 2015-02-02T00:00:00Z
date_updated: 2025-09-23T07:53:52Z
day: '02'
department:
- _id: NiBa
doi: 10.1103/PhysRevE.91.022803
external_id:
  arxiv:
  - '1012.3298'
  isi:
  - '000349860900006'
intvolume: '        91'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1012.3298
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review E Statistical Nonlinear and Soft Matter Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '5213'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anomalous scaling in an age-dependent branching model
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 91
year: '2015'
...
