[{"publication":"Neuron","scopus_import":"1","status":"public","publisher":"Elsevier","citation":{"ieee":"A. Pernia-Andrade and P. M. Jonas, “The multiple faces of RIM,” <i>Neuron</i>, vol. 69, no. 2. Elsevier, pp. 185–187, 2011.","chicago":"Pernia-Andrade, Alejandro, and Peter M Jonas. “The Multiple Faces of RIM.” <i>Neuron</i>. Elsevier, 2011. <a href=\"https://doi.org/10.1016/j.neuron.2011.01.010\">https://doi.org/10.1016/j.neuron.2011.01.010</a>.","ista":"Pernia-Andrade A, Jonas PM. 2011. The multiple faces of RIM. Neuron. 69(2), 185–187.","short":"A. Pernia-Andrade, P.M. Jonas, Neuron 69 (2011) 185–187.","apa":"Pernia-Andrade, A., &#38; Jonas, P. M. (2011). The multiple faces of RIM. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2011.01.010\">https://doi.org/10.1016/j.neuron.2011.01.010</a>","ama":"Pernia-Andrade A, Jonas PM. The multiple faces of RIM. <i>Neuron</i>. 2011;69(2):185-187. doi:<a href=\"https://doi.org/10.1016/j.neuron.2011.01.010\">10.1016/j.neuron.2011.01.010</a>","mla":"Pernia-Andrade, Alejandro, and Peter M. Jonas. “The Multiple Faces of RIM.” <i>Neuron</i>, vol. 69, no. 2, Elsevier, 2011, pp. 185–87, doi:<a href=\"https://doi.org/10.1016/j.neuron.2011.01.010\">10.1016/j.neuron.2011.01.010</a>."},"author":[{"id":"36963E98-F248-11E8-B48F-1D18A9856A87","last_name":"Pernia-Andrade","first_name":"Alejandro","full_name":"Pernia-Andrade, Alejandro"},{"first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"}],"date_updated":"2025-09-30T09:01:26Z","quality_controlled":"1","oa_version":"None","abstract":[{"lang":"eng","text":"Rab3 interacting molecules (RIMs) are highly enriched in the active zones of presynaptic terminals. It is generally thought that they operate as effectors of the small G protein Rab3. Three recent papers, by Han et al. (this issue of Neuron), Deng et al. (this issue of Neuron), and Kaeser et al. (a recent issue of Cell), shed new light on the functional role of RIM in presynaptic terminals. First, RIM tethers Ca2+ channels to active zones. Second, RIM contributes to priming of synaptic vesicles by interacting with another presynaptic protein, Munc13."}],"corr_author":"1","page":"185 - 187","publication_status":"published","doi":"10.1016/j.neuron.2011.01.010","publist_id":"3243","day":"27","isi":1,"department":[{"_id":"PeJo"}],"date_published":"2011-01-27T00:00:00Z","_id":"3369","external_id":{"isi":["000286792900002"]},"title":"The multiple faces of RIM","year":"2011","date_created":"2018-12-11T12:02:56Z","type":"journal_article","month":"01","article_processing_charge":"No","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","issue":"2","language":[{"iso":"eng"}],"intvolume":"        69","volume":69},{"doi":"10.1016/j.neuropharm.2010.05.013","day":"01","publist_id":"2512","department":[{"_id":"PeJo"}],"isi":1,"oa_version":"None","page":"406 - 415","abstract":[{"lang":"eng","text":"Long-term depression (LTD) is a form of synaptic plasticity that may contribute to information storage in the central nervous system. Here we report that LTD can be elicited in layer 5 pyramidal neurons of the rat prefrontal cortex by pairing low frequency stimulation with a modest postsynaptic depolarization. The induction of LTD required the activation of both metabotropic glutamate receptors of the mGlu1 subtype and voltage-sensitive Ca(2+) channels (VSCCs) of the T/R, P/Q and N types, leading to the stimulation of intracellular inositol trisphosphate (IP3) receptors by IP3 and Ca(2+). The subsequent release of Ca(2+) from intracellular stores activated the protein phosphatase cascade involving calcineurin and protein phosphatase 1. The activation of purinergic P2Y(1) receptors blocked LTD. This effect was prevented by P2Y(1) receptor antagonists and was absent in mice lacking P2Y(1) but not P2Y(2) receptors. We also found that activation of P2Y(1) receptors inhibits Ca(2+) transients via VSCCs in the apical dendrites and spines of pyramidal neurons. In addition, we show that the release of ATP under hypoxia is able to inhibit LTD by acting on postsynaptic P2Y(1) receptors. In conclusion, these data suggest that the reduction of Ca(2+) influx via VSCCs caused by the activation of P2Y(1) receptors by ATP is the possible mechanism for the inhibition of LTD in prefrontal cortex."}],"corr_author":"1","publication_status":"published","publisher":"Elsevier","citation":{"short":"J. Guzmán, H. Schmidt, H. Franke, U. Krügel, J. Eilers, P. Illes, Z. Gerevich, Neuropharmacology 59 (2010) 406–415.","apa":"Guzmán, J., Schmidt, H., Franke, H., Krügel, U., Eilers, J., Illes, P., &#38; Gerevich, Z. (2010). P2Y1 receptors inhibit long-term depression in the prefrontal cortex. <i>Neuropharmacology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuropharm.2010.05.013\">https://doi.org/10.1016/j.neuropharm.2010.05.013</a>","chicago":"Guzmán, José, Hartmut Schmidt, Heike Franke, Ute Krügel, Jens Eilers, Peter Illes, and Zoltan Gerevich. “P2Y1 Receptors Inhibit Long-Term Depression in the Prefrontal Cortex.” <i>Neuropharmacology</i>. Elsevier, 2010. <a href=\"https://doi.org/10.1016/j.neuropharm.2010.05.013\">https://doi.org/10.1016/j.neuropharm.2010.05.013</a>.","ieee":"J. Guzmán <i>et al.</i>, “P2Y1 receptors inhibit long-term depression in the prefrontal cortex.,” <i>Neuropharmacology</i>, vol. 59, no. 6. Elsevier, pp. 406–415, 2010.","ista":"Guzmán J, Schmidt H, Franke H, Krügel U, Eilers J, Illes P, Gerevich Z. 2010. P2Y1 receptors inhibit long-term depression in the prefrontal cortex. Neuropharmacology. 59(6), 406–415.","mla":"Guzmán, José, et al. “P2Y1 Receptors Inhibit Long-Term Depression in the Prefrontal Cortex.” <i>Neuropharmacology</i>, vol. 59, no. 6, Elsevier, 2010, pp. 406–15, doi:<a href=\"https://doi.org/10.1016/j.neuropharm.2010.05.013\">10.1016/j.neuropharm.2010.05.013</a>.","ama":"Guzmán J, Schmidt H, Franke H, et al. P2Y1 receptors inhibit long-term depression in the prefrontal cortex. <i>Neuropharmacology</i>. 2010;59(6):406-415. doi:<a href=\"https://doi.org/10.1016/j.neuropharm.2010.05.013\">10.1016/j.neuropharm.2010.05.013</a>"},"date_updated":"2025-09-30T09:46:27Z","author":[{"id":"30CC5506-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2209-5242","last_name":"Guzmán","first_name":"José","full_name":"Guzmán, José"},{"last_name":"Schmidt","first_name":"Hartmut","full_name":"Schmidt, Hartmut"},{"last_name":"Franke","first_name":"Heike","full_name":"Franke, Heike"},{"first_name":"Ute","full_name":"Krügel, Ute","last_name":"Krügel"},{"full_name":"Eilers, Jens","first_name":"Jens","last_name":"Eilers"},{"full_name":"Illes, Peter","first_name":"Peter","last_name":"Illes"},{"last_name":"Gerevich","full_name":"Gerevich, Zoltan","first_name":"Zoltan"}],"quality_controlled":"1","publication":"Neuropharmacology","scopus_import":"1","acknowledgement":" The financial support of the Deutsche Forschungsgemeinschaft (IL 20/12-1, KI 677/2-4) is gratefully acknowledged.\r\nWe thank B. H. Koller (Department of Genetics and Molecular Biology, University of North Carolina at Chapel Hill, NC, USA) for the generous supply of P2Y1−/− and P2Y2−/− mice. We are grateful to Dr. A. Schulz for reanalysing the genotype of the P2Y1−/− mice. The authors thank P. Jonas and U. Heinemann for many helpful comments and A-K. Krause, L Feige and M. Eberts for their excellent technical support.","status":"public","issue":"6","intvolume":"        59","language":[{"iso":"eng"}],"volume":59,"date_created":"2018-12-11T12:04:47Z","type":"journal_article","month":"11","article_processing_charge":"No","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","external_id":{"isi":["000283453300006"]},"title":"P2Y1 receptors inhibit long-term depression in the prefrontal cortex.","year":"2010","date_published":"2010-11-01T00:00:00Z","_id":"3718"},{"doi":"10.1016/j.neuron.2010.04.003","publist_id":"2377","day":"15","isi":1,"department":[{"_id":"PeJo"}],"oa_version":"Published Version","abstract":[{"text":"A recent paper by von Engelhardt et al. identifies a novel auxiliary subunit of native AMPARs, termedCKAMP44. Unlike other auxiliary subunits, CKAMP44 accelerates desensitization and prolongs recovery from desensitization. CKAMP44 is highly expressed in hippocampal dentate gyrus granule cells and decreases the paired-pulse ratio at perforant path input synapses. Thus, both principal and auxiliary AMPAR subunits control the time course of signaling at glutamatergic synapses.","lang":"eng"}],"corr_author":"1","page":"8 - 10","ddc":["570"],"publication_status":"published","publisher":"Elsevier","citation":{"ama":"Guzmán J, Jonas PM. Beyond TARPs: The growing list of auxiliary AMPAR subunits. <i>Neuron</i>. 2010;66(1):8-10. doi:<a href=\"https://doi.org/10.1016/j.neuron.2010.04.003\">10.1016/j.neuron.2010.04.003</a>","mla":"Guzmán, José, and Peter M. Jonas. “Beyond TARPs: The Growing List of Auxiliary AMPAR Subunits.” <i>Neuron</i>, vol. 66, no. 1, Elsevier, 2010, pp. 8–10, doi:<a href=\"https://doi.org/10.1016/j.neuron.2010.04.003\">10.1016/j.neuron.2010.04.003</a>.","ieee":"J. Guzmán and P. M. Jonas, “Beyond TARPs: The growing list of auxiliary AMPAR subunits,” <i>Neuron</i>, vol. 66, no. 1. Elsevier, pp. 8–10, 2010.","ista":"Guzmán J, Jonas PM. 2010. Beyond TARPs: The growing list of auxiliary AMPAR subunits. Neuron. 66(1), 8–10.","chicago":"Guzmán, José, and Peter M Jonas. “Beyond TARPs: The Growing List of Auxiliary AMPAR Subunits.” <i>Neuron</i>. Elsevier, 2010. <a href=\"https://doi.org/10.1016/j.neuron.2010.04.003\">https://doi.org/10.1016/j.neuron.2010.04.003</a>.","apa":"Guzmán, J., &#38; Jonas, P. M. (2010). Beyond TARPs: The growing list of auxiliary AMPAR subunits. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2010.04.003\">https://doi.org/10.1016/j.neuron.2010.04.003</a>","short":"J. Guzmán, P.M. Jonas, Neuron 66 (2010) 8–10."},"author":[{"last_name":"Guzmán","id":"30CC5506-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2209-5242","full_name":"Guzmán, José","first_name":"José"},{"full_name":"Jonas, Peter M","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","last_name":"Jonas"}],"date_updated":"2026-06-18T18:47:22Z","pmid":1,"quality_controlled":"1","publication":"Neuron","scopus_import":"1","oa":1,"status":"public","issue":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/20399724"}],"language":[{"iso":"eng"}],"intvolume":"        66","volume":66,"date_created":"2018-12-11T12:05:25Z","type":"journal_article","month":"04","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["20399724"],"isi":["000277016200004"]},"title":"Beyond TARPs: The growing list of auxiliary AMPAR subunits","year":"2010","date_published":"2010-04-15T00:00:00Z","_id":"3832"},{"date_published":"2010-03-19T00:00:00Z","_id":"3833","title":"GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali &amp; Todorova)","year":"2010","external_id":{"isi":["000276245400005"]},"month":"03","article_processing_charge":"No","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_created":"2018-12-11T12:05:25Z","type":"journal_article","intvolume":"        31","language":[{"iso":"eng"}],"volume":31,"issue":"7","status":"public","publication":"The European Journal of Neuroscience","scopus_import":"1","quality_controlled":"1","publisher":"Wiley-Blackwell","citation":{"ama":"Jonas PM, Hefft S. GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali &#38;amp; Todorova). <i>The European Journal of Neuroscience</i>. 2010;31(7):1194-1195. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2010.07189.x\">10.1111/j.1460-9568.2010.07189.x</a>","mla":"Jonas, Peter M., and Stefan Hefft. “GABA Release at Terminals of CCK-Interneurons: Synchrony, Asynchrony and Modulation by Cannabinoid Receptors (Commentary on Ali &#38;amp; Todorova).” <i>The European Journal of Neuroscience</i>, vol. 31, no. 7, Wiley-Blackwell, 2010, pp. 1194–95, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.2010.07189.x\">10.1111/j.1460-9568.2010.07189.x</a>.","ieee":"P. M. Jonas and S. Hefft, “GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali &#38;amp; Todorova),” <i>The European Journal of Neuroscience</i>, vol. 31, no. 7. Wiley-Blackwell, pp. 1194–1195, 2010.","chicago":"Jonas, Peter M, and Stefan Hefft. “GABA Release at Terminals of CCK-Interneurons: Synchrony, Asynchrony and Modulation by Cannabinoid Receptors (Commentary on Ali &#38;amp; Todorova).” <i>The European Journal of Neuroscience</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1111/j.1460-9568.2010.07189.x\">https://doi.org/10.1111/j.1460-9568.2010.07189.x</a>.","ista":"Jonas PM, Hefft S. 2010. GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali &#38;amp; Todorova). The European Journal of Neuroscience. 31(7), 1194–1195.","short":"P.M. Jonas, S. Hefft, The European Journal of Neuroscience 31 (2010) 1194–1195.","apa":"Jonas, P. M., &#38; Hefft, S. (2010). GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali &#38;amp; Todorova). <i>The European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.2010.07189.x\">https://doi.org/10.1111/j.1460-9568.2010.07189.x</a>"},"date_updated":"2025-09-30T09:38:44Z","author":[{"orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M"},{"first_name":"Stefan","full_name":"Hefft, Stefan","last_name":"Hefft"}],"page":"1194 - 1195","corr_author":"1","publication_status":"published","oa_version":"None","department":[{"_id":"PeJo"}],"isi":1,"doi":"10.1111/j.1460-9568.2010.07189.x","publist_id":"2378","day":"19"}]