---
_id: '490'
abstract:
- lang: eng
text: 'BioSig is an open source software library for biomedical signal processing.
The aim of the BioSig project is to foster research in biomedical signal processing
by providing free and open source software tools for many different application
areas. Some of the areas where BioSig can be employed are neuroinformatics, brain-computer
interfaces, neurophysiology, psychology, cardiovascular systems, and sleep research.
Moreover, the analysis of biosignals such as the electroencephalogram (EEG), electrocorticogram
(ECoG), electrocardiogram (ECG), electrooculogram (EOG), electromyogram (EMG),
or respiration signals is a very relevant element of the BioSig project. Specifically,
BioSig provides solutions for data acquisition, artifact processing, quality control,
feature extraction, classification, modeling, and data visualization, to name
a few. In this paper, we highlight several methods to help students and researchers
to work more efficiently with biomedical signals. '
article_number: '935364'
article_processing_charge: No
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Carmen
full_name: Vidaurre, Carmen
last_name: Vidaurre
- first_name: Tilmann
full_name: Sander, Tilmann
last_name: Sander
citation:
ama: 'Schlögl A, Vidaurre C, Sander T. BioSig: The free and open source software
library for biomedical signal processing. Computational Intelligence and Neuroscience.
2011;2011. doi:10.1155/2011/935364'
apa: 'Schlögl, A., Vidaurre, C., & Sander, T. (2011). BioSig: The free and open
source software library for biomedical signal processing. Computational Intelligence
and Neuroscience. Hindawi Publishing Corporation. https://doi.org/10.1155/2011/935364'
chicago: 'Schlögl, Alois, Carmen Vidaurre, and Tilmann Sander. “BioSig: The Free
and Open Source Software Library for Biomedical Signal Processing.” Computational
Intelligence and Neuroscience. Hindawi Publishing Corporation, 2011. https://doi.org/10.1155/2011/935364.'
ieee: 'A. Schlögl, C. Vidaurre, and T. Sander, “BioSig: The free and open source
software library for biomedical signal processing,” Computational Intelligence
and Neuroscience, vol. 2011. Hindawi Publishing Corporation, 2011.'
ista: 'Schlögl A, Vidaurre C, Sander T. 2011. BioSig: The free and open source software
library for biomedical signal processing. Computational Intelligence and Neuroscience.
2011, 935364.'
mla: 'Schlögl, Alois, et al. “BioSig: The Free and Open Source Software Library
for Biomedical Signal Processing.” Computational Intelligence and Neuroscience,
vol. 2011, 935364, Hindawi Publishing Corporation, 2011, doi:10.1155/2011/935364.'
short: A. Schlögl, C. Vidaurre, T. Sander, Computational Intelligence and Neuroscience
2011 (2011).
corr_author: '1'
date_created: 2018-12-11T11:46:45Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2025-09-30T09:24:43Z
day: '01'
ddc:
- '005'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.1155/2011/935364
external_id:
isi:
- '000208906100033'
file:
- access_level: open_access
checksum: 8263bbf255171f2054f43f3db5f53b6e
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:07:44Z
date_updated: 2020-07-14T12:46:35Z
file_id: '4642'
file_name: IST-2018-947-v1+1_2011_Schloegl_BioSig.pdf
file_size: 2863551
relation: main_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
intvolume: ' 2011'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
publication: Computational Intelligence and Neuroscience
publication_status: published
publisher: Hindawi Publishing Corporation
publist_id: '7330'
pubrep_id: '947'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'BioSig: The free and open source software library for biomedical signal processing'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 2011
year: '2011'
...
---
_id: '3318'
abstract:
- lang: eng
text: Parvalbumin is thought to act in a manner similar to EGTA, but how a slow
Ca2+ buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear.
Direct measurements of parvalbumin concentration and paired recordings in rodent
hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics
only when expressed at high levels. Modeling suggests that, in high concentrations,
parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition
with local saturation of endogenous fixed buffers.
article_processing_charge: No
author:
- first_name: Emmanuel
full_name: Eggermann, Emmanuel
last_name: Eggermann
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Eggermann E, Jonas PM. How the “slow” Ca(2+) buffer parvalbumin affects transmitter
release in nanodomain coupling regimes at GABAergic synapses. Nature Neuroscience.
2011;15:20-22. doi:10.1038/nn.3002
apa: Eggermann, E., & Jonas, P. M. (2011). How the “slow” Ca(2+) buffer parvalbumin
affects transmitter release in nanodomain coupling regimes at GABAergic synapses.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3002
chicago: Eggermann, Emmanuel, and Peter M Jonas. “How the ‘Slow’ Ca(2+) Buffer Parvalbumin
Affects Transmitter Release in Nanodomain Coupling Regimes at GABAergic Synapses.”
Nature Neuroscience. Nature Publishing Group, 2011. https://doi.org/10.1038/nn.3002.
ieee: E. Eggermann and P. M. Jonas, “How the ‘slow’ Ca(2+) buffer parvalbumin affects
transmitter release in nanodomain coupling regimes at GABAergic synapses,” Nature
Neuroscience, vol. 15. Nature Publishing Group, pp. 20–22, 2011.
ista: Eggermann E, Jonas PM. 2011. How the “slow” Ca(2+) buffer parvalbumin affects
transmitter release in nanodomain coupling regimes at GABAergic synapses. Nature
Neuroscience. 15, 20–22.
mla: Eggermann, Emmanuel, and Peter M. Jonas. “How the ‘Slow’ Ca(2+) Buffer Parvalbumin
Affects Transmitter Release in Nanodomain Coupling Regimes at GABAergic Synapses.”
Nature Neuroscience, vol. 15, Nature Publishing Group, 2011, pp. 20–22,
doi:10.1038/nn.3002.
short: E. Eggermann, P.M. Jonas, Nature Neuroscience 15 (2011) 20–22.
corr_author: '1'
date_created: 2018-12-11T12:02:38Z
date_published: 2011-12-04T00:00:00Z
date_updated: 2025-09-30T09:20:05Z
day: '04'
department:
- _id: PeJo
doi: 10.1038/nn.3002
external_id:
isi:
- '000298414400008'
intvolume: ' 15'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631701/
month: '12'
oa: 1
oa_version: Submitted Version
page: 20 - 22
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3321'
quality_controlled: '1'
scopus_import: '1'
status: public
title: How the “slow” Ca(2+) buffer parvalbumin affects transmitter release in nanodomain
coupling regimes at GABAergic synapses
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2011'
...
---
_id: '3369'
abstract:
- lang: eng
text: Rab3 interacting molecules (RIMs) are highly enriched in the active zones
of presynaptic terminals. It is generally thought that they operate as effectors
of the small G protein Rab3. Three recent papers, by Han et al. (this issue of
Neuron), Deng et al. (this issue of Neuron), and Kaeser et al. (a recent issue
of Cell), shed new light on the functional role of RIM in presynaptic terminals.
First, RIM tethers Ca2+ channels to active zones. Second, RIM contributes to priming
of synaptic vesicles by interacting with another presynaptic protein, Munc13.
article_processing_charge: No
author:
- first_name: Alejandro
full_name: Pernia-Andrade, Alejandro
id: 36963E98-F248-11E8-B48F-1D18A9856A87
last_name: Pernia-Andrade
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Pernia-Andrade A, Jonas PM. The multiple faces of RIM. Neuron. 2011;69(2):185-187.
doi:10.1016/j.neuron.2011.01.010
apa: Pernia-Andrade, A., & Jonas, P. M. (2011). The multiple faces of RIM. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2011.01.010
chicago: Pernia-Andrade, Alejandro, and Peter M Jonas. “The Multiple Faces of RIM.”
Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.01.010.
ieee: A. Pernia-Andrade and P. M. Jonas, “The multiple faces of RIM,” Neuron,
vol. 69, no. 2. Elsevier, pp. 185–187, 2011.
ista: Pernia-Andrade A, Jonas PM. 2011. The multiple faces of RIM. Neuron. 69(2),
185–187.
mla: Pernia-Andrade, Alejandro, and Peter M. Jonas. “The Multiple Faces of RIM.”
Neuron, vol. 69, no. 2, Elsevier, 2011, pp. 185–87, doi:10.1016/j.neuron.2011.01.010.
short: A. Pernia-Andrade, P.M. Jonas, Neuron 69 (2011) 185–187.
corr_author: '1'
date_created: 2018-12-11T12:02:56Z
date_published: 2011-01-27T00:00:00Z
date_updated: 2025-09-30T09:01:26Z
day: '27'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2011.01.010
external_id:
isi:
- '000286792900002'
intvolume: ' 69'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 185 - 187
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '3243'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The multiple faces of RIM
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 69
year: '2011'
...
---
_id: '3718'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that may contribute
to information storage in the central nervous system. Here we report that LTD
can be elicited in layer 5 pyramidal neurons of the rat prefrontal cortex by pairing
low frequency stimulation with a modest postsynaptic depolarization. The induction
of LTD required the activation of both metabotropic glutamate receptors of the
mGlu1 subtype and voltage-sensitive Ca(2+) channels (VSCCs) of the T/R, P/Q and
N types, leading to the stimulation of intracellular inositol trisphosphate (IP3)
receptors by IP3 and Ca(2+). The subsequent release of Ca(2+) from intracellular
stores activated the protein phosphatase cascade involving calcineurin and protein
phosphatase 1. The activation of purinergic P2Y(1) receptors blocked LTD. This
effect was prevented by P2Y(1) receptor antagonists and was absent in mice lacking
P2Y(1) but not P2Y(2) receptors. We also found that activation of P2Y(1) receptors
inhibits Ca(2+) transients via VSCCs in the apical dendrites and spines of pyramidal
neurons. In addition, we show that the release of ATP under hypoxia is able to
inhibit LTD by acting on postsynaptic P2Y(1) receptors. In conclusion, these data
suggest that the reduction of Ca(2+) influx via VSCCs caused by the activation
of P2Y(1) receptors by ATP is the possible mechanism for the inhibition of LTD
in prefrontal cortex.
acknowledgement: " The financial support of the Deutsche Forschungsgemeinschaft (IL
20/12-1, KI 677/2-4) is gratefully acknowledged.\r\nWe thank B. H. Koller (Department
of Genetics and Molecular Biology, University of North Carolina at Chapel Hill,
NC, USA) for the generous supply of P2Y1−/− and P2Y2−/− mice. We are grateful to
Dr. A. Schulz for reanalysing the genotype of the P2Y1−/− mice. The authors thank
P. Jonas and U. Heinemann for many helpful comments and A-K. Krause, L Feige and
M. Eberts for their excellent technical support."
article_processing_charge: No
author:
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Hartmut
full_name: Schmidt, Hartmut
last_name: Schmidt
- first_name: Heike
full_name: Franke, Heike
last_name: Franke
- first_name: Ute
full_name: Krügel, Ute
last_name: Krügel
- first_name: Jens
full_name: Eilers, Jens
last_name: Eilers
- first_name: Peter
full_name: Illes, Peter
last_name: Illes
- first_name: Zoltan
full_name: Gerevich, Zoltan
last_name: Gerevich
citation:
ama: Guzmán J, Schmidt H, Franke H, et al. P2Y1 receptors inhibit long-term depression
in the prefrontal cortex. Neuropharmacology. 2010;59(6):406-415. doi:10.1016/j.neuropharm.2010.05.013
apa: Guzmán, J., Schmidt, H., Franke, H., Krügel, U., Eilers, J., Illes, P., &
Gerevich, Z. (2010). P2Y1 receptors inhibit long-term depression in the prefrontal
cortex. Neuropharmacology. Elsevier. https://doi.org/10.1016/j.neuropharm.2010.05.013
chicago: Guzmán, José, Hartmut Schmidt, Heike Franke, Ute Krügel, Jens Eilers, Peter
Illes, and Zoltan Gerevich. “P2Y1 Receptors Inhibit Long-Term Depression in the
Prefrontal Cortex.” Neuropharmacology. Elsevier, 2010. https://doi.org/10.1016/j.neuropharm.2010.05.013.
ieee: J. Guzmán et al., “P2Y1 receptors inhibit long-term depression in the
prefrontal cortex.,” Neuropharmacology, vol. 59, no. 6. Elsevier, pp. 406–415,
2010.
ista: Guzmán J, Schmidt H, Franke H, Krügel U, Eilers J, Illes P, Gerevich Z. 2010.
P2Y1 receptors inhibit long-term depression in the prefrontal cortex. Neuropharmacology.
59(6), 406–415.
mla: Guzmán, José, et al. “P2Y1 Receptors Inhibit Long-Term Depression in the Prefrontal
Cortex.” Neuropharmacology, vol. 59, no. 6, Elsevier, 2010, pp. 406–15,
doi:10.1016/j.neuropharm.2010.05.013.
short: J. Guzmán, H. Schmidt, H. Franke, U. Krügel, J. Eilers, P. Illes, Z. Gerevich,
Neuropharmacology 59 (2010) 406–415.
corr_author: '1'
date_created: 2018-12-11T12:04:47Z
date_published: 2010-11-01T00:00:00Z
date_updated: 2025-09-30T09:46:27Z
day: '01'
department:
- _id: PeJo
doi: 10.1016/j.neuropharm.2010.05.013
external_id:
isi:
- '000283453300006'
intvolume: ' 59'
isi: 1
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 406 - 415
publication: Neuropharmacology
publication_status: published
publisher: Elsevier
publist_id: '2512'
quality_controlled: '1'
scopus_import: '1'
status: public
title: P2Y1 receptors inhibit long-term depression in the prefrontal cortex.
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 59
year: '2010'
...
---
_id: '3832'
abstract:
- lang: eng
text: A recent paper by von Engelhardt et al. identifies a novel auxiliary subunit
of native AMPARs, termedCKAMP44. Unlike other auxiliary subunits, CKAMP44 accelerates
desensitization and prolongs recovery from desensitization. CKAMP44 is highly
expressed in hippocampal dentate gyrus granule cells and decreases the paired-pulse
ratio at perforant path input synapses. Thus, both principal and auxiliary AMPAR
subunits control the time course of signaling at glutamatergic synapses.
article_processing_charge: No
author:
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Guzmán J, Jonas PM. Beyond TARPs: The growing list of auxiliary AMPAR subunits.
Neuron. 2010;66(1):8-10. doi:10.1016/j.neuron.2010.04.003'
apa: 'Guzmán, J., & Jonas, P. M. (2010). Beyond TARPs: The growing list of auxiliary
AMPAR subunits. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2010.04.003'
chicago: 'Guzmán, José, and Peter M Jonas. “Beyond TARPs: The Growing List of Auxiliary
AMPAR Subunits.” Neuron. Elsevier, 2010. https://doi.org/10.1016/j.neuron.2010.04.003.'
ieee: 'J. Guzmán and P. M. Jonas, “Beyond TARPs: The growing list of auxiliary AMPAR
subunits,” Neuron, vol. 66, no. 1. Elsevier, pp. 8–10, 2010.'
ista: 'Guzmán J, Jonas PM. 2010. Beyond TARPs: The growing list of auxiliary AMPAR
subunits. Neuron. 66(1), 8–10.'
mla: 'Guzmán, José, and Peter M. Jonas. “Beyond TARPs: The Growing List of Auxiliary
AMPAR Subunits.” Neuron, vol. 66, no. 1, Elsevier, 2010, pp. 8–10, doi:10.1016/j.neuron.2010.04.003.'
short: J. Guzmán, P.M. Jonas, Neuron 66 (2010) 8–10.
corr_author: '1'
date_created: 2018-12-11T12:05:25Z
date_published: 2010-04-15T00:00:00Z
date_updated: 2026-06-18T18:47:22Z
day: '15'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2010.04.003
external_id:
isi:
- '000277016200004'
pmid:
- '20399724'
intvolume: ' 66'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pubmed/20399724
month: '04'
oa: 1
oa_version: Published Version
page: 8 - 10
pmid: 1
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2377'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Beyond TARPs: The growing list of auxiliary AMPAR subunits'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2010'
...
---
_id: '3833'
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Stefan
full_name: Hefft, Stefan
last_name: Hefft
citation:
ama: 'Jonas PM, Hefft S. GABA release at terminals of CCK-interneurons: Synchrony,
asynchrony and modulation by cannabinoid receptors (commentary on Ali &
Todorova). The European Journal of Neuroscience. 2010;31(7):1194-1195.
doi:10.1111/j.1460-9568.2010.07189.x'
apa: 'Jonas, P. M., & Hefft, S. (2010). GABA release at terminals of CCK-interneurons:
Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali
& Todorova). The European Journal of Neuroscience. Wiley-Blackwell.
https://doi.org/10.1111/j.1460-9568.2010.07189.x'
chicago: 'Jonas, Peter M, and Stefan Hefft. “GABA Release at Terminals of CCK-Interneurons:
Synchrony, Asynchrony and Modulation by Cannabinoid Receptors (Commentary on Ali
& Todorova).” The European Journal of Neuroscience. Wiley-Blackwell,
2010. https://doi.org/10.1111/j.1460-9568.2010.07189.x.'
ieee: 'P. M. Jonas and S. Hefft, “GABA release at terminals of CCK-interneurons:
Synchrony, asynchrony and modulation by cannabinoid receptors (commentary on Ali
& Todorova),” The European Journal of Neuroscience, vol. 31, no.
7. Wiley-Blackwell, pp. 1194–1195, 2010.'
ista: 'Jonas PM, Hefft S. 2010. GABA release at terminals of CCK-interneurons: Synchrony,
asynchrony and modulation by cannabinoid receptors (commentary on Ali &
Todorova). The European Journal of Neuroscience. 31(7), 1194–1195.'
mla: 'Jonas, Peter M., and Stefan Hefft. “GABA Release at Terminals of CCK-Interneurons:
Synchrony, Asynchrony and Modulation by Cannabinoid Receptors (Commentary on Ali
& Todorova).” The European Journal of Neuroscience, vol. 31, no.
7, Wiley-Blackwell, 2010, pp. 1194–95, doi:10.1111/j.1460-9568.2010.07189.x.'
short: P.M. Jonas, S. Hefft, The European Journal of Neuroscience 31 (2010) 1194–1195.
corr_author: '1'
date_created: 2018-12-11T12:05:25Z
date_published: 2010-03-19T00:00:00Z
date_updated: 2025-09-30T09:38:44Z
day: '19'
department:
- _id: PeJo
doi: 10.1111/j.1460-9568.2010.07189.x
external_id:
isi:
- '000276245400005'
intvolume: ' 31'
isi: 1
issue: '7'
language:
- iso: eng
month: '03'
oa_version: None
page: 1194 - 1195
publication: The European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2378'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'GABA release at terminals of CCK-interneurons: Synchrony, asynchrony and modulation
by cannabinoid receptors (commentary on Ali & Todorova)'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 31
year: '2010'
...