@article{14703, abstract = {We present a discretization of the dynamic optimal transport problem for which we can obtain the convergence rate for the value of the transport cost to its continuous value when the temporal and spatial stepsize vanish. This convergence result does not require any regularity assumption on the measures, though experiments suggest that the rate is not sharp. Via an analysis of the duality gap we also obtain the convergence rates for the gradient of the optimal potentials and the velocity field under mild regularity assumptions. To obtain such rates we discretize the dual formulation of the dynamic optimal transport problem and use the mature literature related to the error due to discretizing the Hamilton-Jacobi equation.}, author = {Ishida, Sadashige and Lavenant, Hugo}, issn = {1615-3383}, journal = {Foundations of Computational Mathematics}, keywords = {Optimal transport, Hamilton-Jacobi equation, convex optimization}, pages = {349--384}, publisher = {Springer Nature}, title = {{Quantitative convergence of a discretization of dynamic optimal transport using the dual formulation}}, doi = {10.1007/s10208-024-09686-3}, volume = {26}, year = {2026}, } @article{20851, abstract = {High-voltage disordered spinel LiNi0.5Mn1.5O4 is a promising cathode material for high power density in lithium-ion batteries. However, it suffers from poor cycle life associated with the rock-salt phase transformation. This study presents a straightforward synthesis approach to enhance the electrochemical performance of LiNi0.5Mn1.5O4 through a synergistic solid-state modification with LiF and AlF3. This dual modification promotes rapid Li⁺ diffusion, enables near-complete delithiation/lithiation, approaching the theoretical capacity of disordered LiNi0.5Mn1.5O4, and, more importantly, effectively mitigates the formation of the rock-salt phase, thereby enhancing structural stability, as confirmed by operando X-ray absorption spectroscopy (XAS) and synchrotron X-ray diffraction (SXRD). As a result, the optimized LiNi0.5Mn1.5O4 (10 mg AlF3 + 30 mg LiF) delivers high reversible capacities of 142.1, 139.1, 129.2, 121.6, 110.3, 93.5, and 76.1 mAh∙g−1 at 0.2C, 0.5C, 1.0C, 2.0C, 3.0C, 4.0C, and 5.0C, respectively. Full cells using graphite as the anode and a high-loading cathode exhibit excellent cycling performance. They retain 80% of their capacity after 200 cycles at 0.5C within a voltage window of 3.5–4.9 V with cathode loading of 11 mg∙cm−2. The findings of this study will significantly advance high-power LiNi0.5Mn1.5O4 materials, offering improved battery life and thereby enhancing their potential for practical applications.}, author = {Chang, Xingqi and Escudero, Carlos and Black, Ashley P. and Horta, Sharona and Martínez, Elías and Lu, Xuan and Llorca, Jordi and Ibáñez, Maria and Biendicho, Jordi Jacas and Cabot, Andreu}, issn = {2198-3844}, journal = {Advanced Science}, keywords = {disordered spinel LiNi0.5Mn1.5O4 (LNMO), generation 3b batteries, operando SXRD, operando XAS, rock-salt, solid-state synthesis}, number = {11}, publisher = {Wiley}, title = {{Mitigating the rock-salt phase transformation in disordered LNMO through synergetic solid-state AlF3/LiF modifications}}, doi = {10.1002/advs.202515962}, volume = {13}, year = {2026}, } @article{20933, abstract = {Photo-responsive systems based on azobenzenes usually require UV light for E→Z isomerization, limiting their applicability, especially in biomedical contexts. Disequilibration by sensitization of azobenzene under confinement (DESC) has recently emerged as a supramolecular strategy to bypass this limitation without the need to derivatize the azobenzene scaffold. Here, we expand DESC to water-soluble azopolymers obtained by RAFT polymerization and systematically investigate the interplay between the polymer structure and DESC efficiency. Using this approach, we achieved as much as 85% of the direct photoexcitation (UV) switching efficiency, while utilizing low-energy (yellow) light. These results establish general design principles for combining DESC with polymeric systems, opening new opportunities for the development of functional materials driven with low-energy light.}, author = {Meteling, Henning Jörn and Gemen, Julius and Häkkinen, Satu and Klajn, Rafal and Priimagi, Arri}, issn = {1521-3773}, journal = {Angewandte Chemie International Edition}, number = {7}, publisher = {Wiley}, title = {{Sensitized disequilibration of water-soluble azopolymers}}, doi = {10.1002/anie.202523447}, volume = {65}, year = {2026}, } @article{20925, abstract = {We prove normal typicality and dynamical typicality for a (centered) random block-band matrix model with block-dependent variances. A key feature of our model is that we achieve intermediate equilibration times, an aspect that has not been proven rigorously in any model before. Our proof builds on recently established concentration estimates for products of resolvents of Wigner type random matrices (Erdős and Riabov in Commun Math Phys 405(12): 282, 2024) and an intricate analysis of the deterministic approximation.}, author = {Erdös, László and Henheik, Sven Joscha and Vogel, Cornelia}, issn = {1573-0530}, journal = {Letters in Mathematical Physics}, publisher = {Springer Nature}, title = {{Normal typicality and dynamical typicality for a random block-band matrix model}}, doi = {10.1007/s11005-025-02037-5}, volume = {116}, year = {2026}, } @article{20924, abstract = {Pioneer transcription factors (TFs) possess the ability to read out DNA motifs embedded within nucleosomes, driving changes in gene expression during cellular differentiation and reprogramming. Here, we present selected engagement on nucleosome sequencing (SeEN-seq), a protocol designed to systematically identify potential TF-binding sites on the nucleosome. We describe steps for nucleosome library assembly, SeEN-seq assay, and cryoelectron microscopy (cryo-EM) sample preparation. This protocol facilitates the preparation of homogeneous pioneer TF-nucleosome complexes for cryo-EM structure determination using single-particle analysis. For complete details on the use and execution of this protocol, please refer to Michael et al.1}, author = {Kobayashi, Wataru and Michael, Alicia and Ruangroengkulrith, Siwat and Kümmecke, Maximilian and Tachibana, Kikuë}, issn = {2666-1667}, journal = {STAR Protocols}, number = {1}, publisher = {Elsevier}, title = {{Protocol for integrative analysis of transcription factor-nucleosome interactions using SeEN-seq and cryo-EM structure determination}}, doi = {10.1016/j.xpro.2025.104295}, volume = {7}, year = {2026}, } @article{17437, abstract = {We prove that the zero-fiber of the moment map of a totally negative quiver has rational singularities. Our proof consists in generalizing dimension bounds on jet spaces of this fiber, which were introduced by Budur. We also transfer the rational singularities property to other moduli spaces of objects in 2-Calabi-Yau categories, based on recent work of Davison. This has interesting arithmetic applications on quiver moment maps and moduli spaces of objects in 2-Calabi-Yau categories. First, we generalize results of Wyss on the asymptotic behaviour of counts of jets of quiver moment maps over finite fields. Moreover, we interpret the limit of counts of jets on a given moduli space as its p-adic volume under a canonical measure analogous to the measure built by Carocci, Orecchia and Wyss on certain moduli spaces of coherent sheaves.}, author = {Vernet, Tanguy}, issn = {1531-586X}, journal = {Transformation Groups}, pages = {1047--1083}, publisher = {Springer Nature}, title = {{Rational singularities for moment maps of totally negative quivers}}, doi = {10.1007/s00031-024-09873-0}, volume = {31}, year = {2026}, } @article{20973, abstract = {CuAgSe-based materials are attractive for low-temperature thermoelectric (TE) applications but are limited by bipolar conduction and relatively high thermal conductivity. Herein, we report a ligand-free aqueous synthesis of Te-doped CuAgSe (CuAgSe1-xTex), where structural and electronic modulation improve carrier transport and suppress phonon propagation. Ex-situ time-resolved X-ray diffraction reveals a spontaneous growth mechanism, while density functional theory calculations show that Te-5s and 5p orbitals hybridization generates localized states and an asymmetric density of states, thereby enhancing the Seebeck coefficient. Electron microscopy and strain analyses confirm that Te-doping introduces a high density of lattice dislocations and grain boundaries, leading to a reduced lattice thermal conductivity of 0.11 W m−1K−1 at 443 K. These synergistic effects translate into device-level performance—the first integrated CuAgSe thermoelectric modules, exhibit a maximum cooling temperature difference of 27.3 K, and power density of 0.34 W cm−2 with a conversion efficiency of 3.6% at a modest temperature gradient of 136 K. These results demonstrate that CuAgSe1-xTex enables efficient energy harvesting and localized cooling under small temperature gradient, underscoring the importance of structural and electronic design beyond conventional zT benchmarks.}, author = {Meng, Weite and Li, Mingquan and Wang, Qingyue and Song, Pingan and Yang, Xuan and Wang, Wen Jun and Hong, Min and Ibáñez, Maria and Cabot, Andreu and Zhang, Yu and Liu, Yu and Lim, Khak Ho}, issn = {1613-6829}, journal = {Small}, number = {25}, publisher = {Wiley}, title = {{Efficient near room temperature thermoelectric cooling and power generation with CuAgSe}}, doi = {10.1002/smll.202513035}, volume = {22}, year = {2026}, } @article{21017, abstract = {With the growing interest in blockchains, permissioned approaches to consensus have received increasing attention. Unfortunately, the BFT consensus algorithms that are the backbone of most of these blockchains scale poorly and offer limited throughput. In fact, many state-of-the-art BFT consensus algorithms require a single leader process to receive and validate votes from a quorum of processes and then broadcast the result, which is inherently non-scalable. Recent approaches avoid this bottleneck by using dissemination/aggregation trees to propagate values and collect and validate votes. However, the use of trees increases the round latency, which limits the throughput for deeper trees. In this paper we propose Kauri, a BFT communication abstraction that sustains high throughput as the system size grows by leveraging a novel pipelining technique to perform scalable dissemination and aggregation on trees. Furthermore, when the number of faults is moderate (arguably the most common case in practice), our construction is able to recover from faults in an optimal number of reconfiguration steps. We implemented and experimentally evaluated Kauri with up to 800 processes. Our results show that Kauri outperforms the throughput of state-of-the-art permissioned blockchain protocols, by up to 58x without compromising latency. Interestingly, in some cases, the parallelization provided by Kauri can also decrease the latency.}, author = {Neiheiser, Ray and Matos, Miguel and Rodrigues, Luis}, issn = {1557-7333}, journal = {ACM Transactions on Computer Systems}, keywords = {Distributed systems, byzantine fault tolerance, blockchain, vote aggregation, pipelining}, number = {2}, publisher = {Association for Computing Machinery}, title = {{Kauri: BFT consensus with pipelined tree-based dissemination and aggregation}}, doi = {10.1145/3769423}, volume = {44}, year = {2026}, } @article{14278, abstract = {The Birkhoff conjecture says that the boundary of a strictly convex integrable billiard table is necessarily an ellipse. In this article, we consider a stronger notion of integrability, namely, integrability close to the boundary, and prove a local version of this conjecture: a small perturbation of almost every ellipse that preserves integrability near the boundary, is itself an ellipse. We apply this result to study local spectral uniqueness of ellipses using the connection between the wave trace of the Laplacian and the dynamics near the boundary and establish local uniqueness for almost all of them.}, author = {Koval, Illya}, issn = {1432-1297}, journal = {Inventiones Mathematicae}, pages = {221--298}, publisher = {Springer Nature}, title = {{Local strong Birkhoff conjecture and local spectral rigidity of almost every ellipse}}, doi = {10.1007/s00222-025-01397-y}, volume = {244}, year = {2026}, } @article{21264, abstract = {Rodents' ability to encode the whisking phase has been extensively documented through neuronal recordings from ascending sensory pathways. Yet, while indicating that reafference originates from the mechanoreceptors, the mechanistic underpinnings of the whisking phase encoding within the follicle remain unclear. Here we present anatomical, histological, and biomechanical evidence for the presence of a distinctive elastic segment (ES) within the basal part of the whisker shaft inside the follicle. This ES, composed of immature keratin, is capable of both bending and twisting. Forces generated by whisker movement deform this segment, causing whisker shaft deflections that can stimulate specific mechanoreceptor subsets within the follicle at different phases of the whisking cycle. This mechanism appears to operate during both free‐air whisking and object contact. We propose that the ES enables torsion‐based mechanoreceptor activation, allowing encoding of the whisking phase.}, author = {Haidarliu, Sebastian and Nelinger, Guy and Gantar, Luka and Ahissar, Ehud and Saraf‐Sinik, Inbar}, issn = {1932-8494}, journal = {The Anatomical Record}, number = {7}, pages = {1910--1924}, publisher = {Wiley}, title = {{An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice}}, doi = {10.1002/ar.70051}, volume = {309}, year = {2026}, } @article{20078, abstract = {Let A be an abelian variety defined over a number field K, E/K be an elliptic curve, and ϕ : A → Em be an isogeny defined over K. Let P ∈ A(K) be such that ϕ(P)=(Q1,..., Qm) with RankZ(⟨Q1,...,Qm⟩)=1. We will study a divisibility sequence related to the point P and show its relation with elliptic divisibility sequences.}, author = {Barańczuk, Stefan and Naskręcki, Bartosz and Verzobio, Matteo}, issn = {0022-314X}, journal = {Journal of Number Theory}, keywords = {Divisibility sequences, Abelian varieties, Elliptic divisibility sequences, Isogenies, Primitive divisors}, pages = {170--183}, publisher = {Elsevier}, title = {{Divisibility sequences related to abelian varieties isogenous to a power of an elliptic curve}}, doi = {10.1016/j.jnt.2025.06.001}, volume = {279}, year = {2026}, } @article{20191, abstract = {High-entropy alloys (HEAs) show great potential for catalyzing complex multi-step reactions, but optimizing their parameters, i.e., composition, but also their crystallinity and morphology, remains a significant challenge. In this study, FeCoNiMoW HEAs are synthesized into either amorphous nanosheets (HEANS) or crystalline nanoparticles (HEANP), which are then used to catalyze the lithium–sulfur (Li–S) reaction of Li–S batteries (LSBs). Evaluations in symmetric cells, coin cells, and pouch cells reveal that HEANS significantly enhance LSB performance, achieving initial discharge capacities up to 1632 mAh g−1. The batteries also exhibit excellent cycling stability over 1000 cycles at 3Cand maintain high-rate performance up to 10C with a capacity of 614 mAh g−1. Comprehensive in situ analyses and density functional theory calculations demonstrate that amorphous HEANS provide more active sites, better ionic conductivity and stronger chemical interactions with lithium polysulfides (LiPS). These properties effectively suppress the shuttle effect, promote the complete S8 → Li2S conversion by reducing the impedance of the solid-electrolyte interphase, and accelerate the Li2S4 → Li2S2 step by lowering the nucleation energy barrier. Overall, this study highlights the superior catalytic properties of amorphous 2D HEAs in LSBs and offers new insights into the mechanisms of LiPS conversion.}, author = {He, Ren and Lee, Seungho and Ding, Yang and Huang, Chen and Lu, Xuan and Zheng, Lirong and Yu, Ao and Zhang, Chaoyue and Li, Canhuang and Bi, Xiaoyu and Li, Yaqiang and Liao, Yaqi and Li, Junshan and Ostovari Moghaddam, Ahmad and Yernar, Salimov and Xu, Ying and Ibáñez, Maria and Zhang, Chaoqi and Yang, Linlin and Zhou, Yingtang and Cabot, Andreu}, issn = {1616-3028}, journal = {Advanced Functional Materials}, keywords = {amorphous, high entropy alloy, in situ electrochemical impedance spec-troscopy, in situ Raman, Li–S batteries}, number = {5}, publisher = {Wiley}, title = {{Amorphous high entropy alloy nanosheets enabling robust Li–S batteries}}, doi = {10.1002/adfm.202513859}, volume = {36}, year = {2026}, } @article{20590, abstract = {Moist convection is a fundamental process occurring in the Earth's atmosphere. It plays a central role in the weather and climate of the Tropics, where, to first order, the heating of the atmosphere by convection is in balance with the cooling of the atmosphere by the emission of radiation to outer space. In this study, we use a cloud-resolving model in radiative–convective equilibrium with an imposed constant rate of radiative cooling and study the response of moist convection to varying this rate of radiative cooling. In particular, we study two types of simulation: varying air temperature (VAT) simulations, where the air temperature is allowed to adjust to the imposed radiative cooling, and constant air temperature (CAT) simulations, where the surface temperature is tuned to ensure that the atmospheric temperature profile in the domain is constant. We recover the previously known result that, in response to increasing radiative cooling, the area of convection expands rapidly, while the intensity of convection does not change. We find that this response is explained by the increased boundary-layer variability in simulations with greater radiative cooling, which compensates for the decreasing temperature by adding a larger initial velocity close to the cloud base. We also propose a fundamental scaling of the non-dimensional cumulus mass flux in moist convection, which is robust across models of different complexity. We aim to bridge the gap between highly idealised prototypes of moist convection, such as the “Rainy–Bénard convection” introduced by Vallis et al., and comprehensive cloud-resolving models.}, author = {Agasthya, Lokahith N and Muller, Caroline J}, issn = {1477-870X}, journal = {Quarterly Journal of the Royal Meteorological Society}, number = {775}, publisher = {Wiley}, title = {{Moist convection and radiative cooling: Dynamical response and scaling}}, doi = {10.1002/qj.70044}, volume = {152}, year = {2026}, } @article{20490, abstract = {We study flips in hypertriangulations of planar points sets. Here a level-k hypertriangulation of n points in the plane is a subdivision induced by the projection of a k-hypersimplex, which is the convex hull of the barycenters of the (k-1)-dimensional faces of the standard (n-1)-simplex. In particular, we introduce four types of flips and prove that the level-2 hypertriangulations are connected by these flips. }, author = {Edelsbrunner, Herbert and Garber, Alexey and Ghafari, Mohadese and Heiss, Teresa and Saghafian, Morteza}, issn = {0195-6698}, journal = {European Journal of Combinatorics}, publisher = {Elsevier}, title = {{Flips in two-dimensional hypertriangulations}}, doi = {10.1016/j.ejc.2025.104248}, volume = {132}, year = {2026}, } @article{20081, abstract = {Information measures can be constructed from Rényi divergences much like mutual information from Kullback-Leibler divergence. One such information measure is known as Sibson α-mutual information and has received renewed attention recently in several contexts: concentration of measure under dependence, statistical learning, hypothesis testing, and estimation theory. In this paper, we survey and extend the state of the art. In particular, we introduce variational representations for Sibson α-mutual information and employ them in each described context to derive novel results. Namely, we produce generalized Transportation-Cost inequalities and Fano-type inequalities. We also present an overview of known applications, spanning from learning theory and Bayesian risk to universal prediction.}, author = {Esposito, Amedeo Roberto and Gastpar, Michael and Issa, Ibrahim}, issn = {1557-9654}, journal = {IEEE Transactions on Information Theory}, number = {7}, pages = {4434--4467}, publisher = {IEEE}, title = {{Sibson α-mutual information and its variational representations}}, doi = {10.1109/TIT.2025.3587340}, volume = {72}, year = {2026}, } @phdthesis{22281, abstract = {In this thesis, we took a look at networks, and more specifically, at networks that change over time, whether those are networks in the distributed algorithms sense of the word, or the graph algorithm sense. In distributed algorithms, we looked at two main problems. First, the broadcast problem: given n agents, each agent is tasked to forward a (unique) message to every other agent. Agents collaborate and can copy and forward all messages they have received up until that point. Broadcast is achieved when one agent has successfully broadcast its message to everyone else. We studied the case where the communication network is controlled by an adversary, under the condition that the graph is rooted in every round of communication. We show that the adversary can delay broadcast for at most l (1 + √ 2)n m rounds, improving on the $O(n\log\log n)$ previous upper bound~\cite{fugger2020radius}, and asymptotically matching the $\sim 1.5n$ lower bound~\cite{schwarz2017linear}. We then looked at the stochastic version of the problem: here, the adversary -- parametrized by $k$ where $k=0$ signifies that the adversary has no control, and $k=n$ that the adversary has full control -- can choose parts of the graph, and the graph is then completed stochastically. Here, we are able to look at a stronger version of broadcast: instead of having $n$ messages trying to be broadcast in parallel, we can assume that only one message needs to be broadcasted. We show the bound $\Theta(k+\log n)$. Then, we looked at undecided states dynamics in population protocols: given a population of $n$ agents, where each initially holds an opinion among $k$ different ones. In each round, two agents are chosen uniformly at random, and can interact. If they have different opinions, they forget their opinions and become undecided. If one of them is undecided while the other has an opinion, they undecided agent copies they opinion of the decided one. The question is then, how many interactions does it take for the whole population to share the same opinion? We show a $\Omega(kn\log \frac {\sqrt n} {k \log n})$ lower bound for any $k = o\left(\frac {\sqrt n}{\log n}\right)$. This is tight for any $ k \le n^{\frac 1 2 - \epsilon}$, where $\epsilon >0$ can be any small constant, matching the known $O(kn\log n)$ upper bound for $k = O\left(\frac {\sqrt n} {\log ^2 n}\right)$~\cite{DBLP:conf/podc/AmirABBHKL23}. Finally, in dynamic algorithms, we study the minimum cut problem: we are given a graph, whose vertex set we want to partition into two subsets such that the number of edges crossing from one subset to the other is minimized. Then, the graph can be updated via edge insertions or deletions, and we must update the solution without recomputing everything from scratch. We present an exact fully-dynamic minimum cut algorithm that runs in $n^{o(1)}$ deterministic update time when the minimum cut size is at most $2^{\Theta(\log^{3/4-c}n)}$ for any $c>0$, improving on the previous algorithm~\cite{DBLP:conf/soda/JinST24} whose minimum cut size limit is $(\log n)^{o(1)}$. Using sparsification and randomization techniques, we are able to extend this to all values of the minimum cut in weighted graphs, at the cost of a $(1+o(1))$-approximation ratio.}, author = {El-Hayek, Antoine}, issn = {2663-337X}, pages = {244}, publisher = {Institute of Science and Technology Austria}, title = {{Handling updates and failures: Dynamic graph algorithms and distributed computing on dynamic networks}}, doi = {10.15479/AT-ISTA-22281}, year = {2026}, } @inproceedings{21720, abstract = {We present an exact fully-dynamic minimum cut algorithm that runs in 𝑛𝑜⁡(1) deterministic update time when the minimum cut size is at most 2Θ⁡(log3/4−𝑐⁡𝑛) for any 𝑐 >0, improving on the previous algorithm of Jin, Sun, and Thorup (SODA 2024) whose minimum cut size limit is (log⁡𝑛)𝑜⁡(1). Combined with graph sparsification, we obtain the first (1 +𝜖)-approximate fully-dynamic minimum cut algorithm on weighted graphs, for any 𝜖 ≥2−Θ⁡(log3/4−𝑐⁡𝑛), in 𝑛𝑜⁡(1) randomized update time. Our main technical contribution is a deterministic local minimum cut algorithm, which replaces the randomized LocalKCut procedure from El-Hayek, Henzinger, and Li (SODA 2025).}, author = {El-Hayek, Antoine and Henzinger, Monika H and Li, Jason}, booktitle = {Proceedings of the Annual ACM SIAM Symposium on Discrete Algorithms}, issn = {1557-9468}, location = {Vancouver, Canada}, pages = {613--663}, publisher = {Society for Industrial and Applied Mathematics}, title = {{Deterministic and exact fully-dynamic minimum cut of superpolylogarithmic size in subpolynomial time}}, doi = {10.1137/1.9781611978971.25}, volume = {2026}, year = {2026}, } @article{22403, abstract = {Linear phase‐contrast scanning transmission electron microscopy (STEM) techniques compatible with high‐throughput 4D‐STEM acquisition are widely used to enhance phase contrast in weakly scattering and beam‐sensitive materials. In these modalities, contrast transfer is often suppressed at low spatial frequencies, resulting in a characteristic contrast gap that limits contrast. Approaches that retain low‐frequency phase contrast exist but typically require substantially increased experimental complexity, restricting routine use. Dark‐field STEM imaging captures this missing low‐frequency information through electrons scattered outside the bright‐field disk, but discards a large fraction of the scattered signal and is therefore dose‐inefficient. Fused Full‐field STEM (FF‐STEM) is introduced as a 4D‐STEM imaging modality that overcomes these limitations by combining ptychographic phase reconstruction with tilt‐corrected dark‐field imaging within a single acquisition. Bright‐field data are used to estimate probe aberrations and reconstruct a high‐resolution phase image, while dark‐field data provide complementary low‐frequency contrast. The two channels are fused in Fourier space using Wiener‐band weighting based on the spectral signal‐to‐noise ratio, yielding transfer‐gap‐free images with high contrast. FF‐STEM preserves the upsampling and depth‐sectioning capabilities of ptychography, adds robust low‐frequency contrast characteristic of dark‐field imaging, and enables dose‐efficient, near–real‐time reconstruction.}, author = {You, Shengbo and Varnavides, Georgios and Khavnekar, Sagar and Palatkin, Nikita and Shao, Sihan and Wu, Mingjian and Stroppa, Daniel and Chernikova, Darya and Zhu, Baixu and Egoavil, Ricardo and Vespucci, Stefano and Krishnan, Dileep and Ye, Xingchen and Schur, Florian KM and Spiecker, Erdmann and Pelz, Philipp}, issn = {2198-3844}, journal = {Advanced Science}, publisher = {Wiley}, title = {{Gap‐free information transfer in 4D‐STEM via fusion of complementary scattering channels}}, doi = {10.1002/advs.76620}, year = {2026}, } @article{20655, abstract = {Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness‐related traits is thus a longstanding puzzle in evolutionary biology, with cascading implications for ecology, conservation, and human health. Balancing selection – an umbrella term for scenarios in which natural selection maintains genetic variation – is a century‐old explanation to resolve this puzzle that has gained recent momentum from genome‐scale methods for detecting it. Yet evaluating whether balancing selection can, in fact, resolve the puzzle is challenging, given the logistical constraints of distinguishing balancing selection from alternative hypotheses and the daunting collection of theoretical models that formally underpin this debate. Here, we track the development of balancing selection theory over the last century and provide an accessible review of this rich collection of models. We first outline the range of biological scenarios that can generate balancing selection. We then examine how fundamental features of genetic systems – non‐random mating between individuals, ploidy levels, genetic drift, linkage, and genetic architectures of traits – have been progressively incorporated into the theory. We end by linking these theoretical predictions to ongoing empirical efforts to understand the evolutionary processes that explain genetic variation.}, author = {Ruzicka, Filip and Zwoinska, Martyna K. and Goedert, Debora and Kokko, Hanna and Li Richter, Xiang‐Yi and Moodie, Iain R. and Nilén, Sofie and Olito, Colin and Svensson, Erik I. and Czuppon, Peter and Connallon, Tim}, issn = {1469-185X}, journal = {Biological Reviews}, keywords = {evolutionary theory, population genetics, balancing selection, heterozygote advantage, trade-offs, negative frequency-dependent selection, fitness variation, mathematical modelling}, number = {2}, publisher = {Wiley}, title = {{A century of theories of balancing selection}}, doi = {10.1111/brv.70103}, volume = {101}, year = {2026}, } @article{20670, abstract = {β-Barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the understanding of the fundamental principles governing ion transport through these nanopores remains largely unexplored. Here we integrate experimental, numerical and theoretical approaches to elucidate ion transport mechanisms in β-barrel nanopores. We identify and characterize two distinct nonlinear phenomena: open-pore rectification and gating. Through extensive mutation analysis of aerolysin nanopores, we demonstrate that open-pore rectification is caused by ionic accumulation driven by the distribution of lumen charges. In addition, we provide converging evidence suggesting that gating is controlled by electric fields dissociating counterions from lumen charges, promoting local structural deformations. Our findings establish a rigorous framework for characterizing and understanding ion transport processes in protein-based nanopores, enabling the design of adaptable nanofluidic biotechnologies. We illustrate this by optimizing an aerolysin mutant for computing applications.}, author = {Mayer, Simon and Mitsioni, Marianna Fanouria and Robin, Paul and Van Den Heuvel, Lukas and Ronceray, Nathan and Marcaida, Maria Jose and Abriata, Luciano A. and Krapp, Lucien F. and Anton, Jana S. and Soussou, Sarah and Jeanneret-Grosjean, Justin and Fulciniti, Alessandro and Möller, Alexia and Vacle, Sarah and Feletti, Lely and Brinkerhoff, Henry and Laszlo, Andrew H. and Gundlach, Jens H. and Emmerich, Theo and Dal Peraro, Matteo and Radenovic, Aleksandra}, issn = {1748-3395}, journal = {Nature Nanotechnology}, pages = {116--124}, publisher = {Springer Nature}, title = {{Lumen charge governs gated ion transport in β-barrel nanopores}}, doi = {10.1038/s41565-025-02052-6}, volume = {21}, year = {2026}, }