@article{10564,
  abstract     = {We study a class of polaron-type Hamiltonians with sufficiently regular form factor in the interaction term. We investigate the strong-coupling limit of the model, and prove suitable bounds on the ground state energy as a function of the total momentum of the system. These bounds agree with the semiclassical approximation to leading order. The latter corresponds here to the situation when the particle undergoes harmonic motion in a potential well whose frequency is determined by the corresponding Pekar functional. We show that for all such models the effective mass diverges in the strong coupling limit, in all spatial dimensions. Moreover, for the case when the phonon dispersion relation grows at least linearly with momentum, the bounds result in an asymptotic formula for the effective mass quotient, a quantity generalizing the usual notion of the effective mass. This asymptotic form agrees with the semiclassical Landau–Pekar formula and can be regarded as the first rigorous confirmation, in a slightly weaker sense than usually considered, of the validity of the semiclassical formula for the effective mass.},
  author       = {Mysliwy, Krzysztof and Seiringer, Robert},
  issn         = {1572-9613},
  journal      = {Journal of Statistical Physics},
  number       = {1},
  publisher    = {Springer Nature},
  title        = {{Polaron models with regular interactions at strong coupling}},
  doi          = {10.1007/s10955-021-02851-w},
  volume       = {186},
  year         = {2022},
}

@article{10566,
  abstract     = {A versatile, scalable, room temperature and surfactant-free route for the synthesis of metal chalcogenide nanoparticles in aqueous solution is detailed here for the production of PbS and Cu-doped PbS nanoparticles. Subsequently, nanoparticles are annealed in a reducing atmosphere to remove surface oxide, and consolidated into dense polycrystalline materials by means of spark plasma sintering. By characterizing the transport properties of the sintered material, we observe the annealing step and the incorporation of Cu to play a key role in promoting the thermoelectric performance of PbS. The presence of Cu allows improving the electrical conductivity by increasing the charge carrier concentration and simultaneously maintaining a large charge carrier mobility, which overall translates into record power factors at ambient temperature, 2.3 mWm-1K−2. Simultaneously, the lattice thermal conductivity decreases with the introduction of Cu, leading to a record high ZT = 0.37 at room temperature and ZT = 1.22 at 773 K. Besides, a record average ZTave = 0.76 is demonstrated in the temperature range 320–773 K for n-type Pb0.955Cu0.045S.},
  author       = {Li, Mengyao and Liu, Yu and Zhang, Yu and Chang, Cheng and Zhang, Ting and Yang, Dawei and Xiao, Ke and Arbiol, Jordi and Ibáñez, Maria and Cabot, Andreu},
  issn         = {1385-8947},
  journal      = {Chemical Engineering Journal},
  publisher    = {Elsevier},
  title        = {{Room temperature aqueous-based synthesis of copper-doped lead sulfide nanoparticles for thermoelectric application}},
  doi          = {10.1016/j.cej.2021.133837},
  volume       = {433},
  year         = {2022},
}

@article{10584,
  abstract     = {Electrically tunable lenses (ETLs) are those with the ability to alter their optical power in response to an electric signal. This feature allows such systems to not only image the areas of interest but also obtain spatial depth perception (depth of field, DOF). The aim of the present study was to develop an ETL-based imaging system for quantitative surface analysis. Firstly, the system was calibrated to achieve high depth resolution, warranting the accurate measurement of the depth and to account for and correct any influences from external factors on the ETL. This was completed using the Tenengrad operator which effectively identified the plane of best focus as demonstrated by the linear relationship between the control current applied to the ETL and the height at which the optical system focuses. The system was then employed to measure amplitude, spatial, hybrid, and volume surface texture parameters of a model material (pharmaceutical dosage form) which were validated against the parameters obtained using a previously validated surface texture analysis technique, optical profilometry. There were no statistically significant differences between the surface texture parameters measured by the techniques, highlighting the potential application of ETL-based imaging systems as an easily adaptable and low-cost alternative surface texture analysis technique to conventional microscopy techniques},
  author       = {Nirwan, Jorabar Singh and Lou, Shan and Hussain, Saqib and Nauman, Muhammad and Hussain, Tariq and Conway, Barbara R. and Ghori, Muhammad Usman},
  issn         = {2072-666X},
  journal      = {Micromachines},
  keywords     = {surface texture, electrically tunable lens, materials, hypromellose, surface topography, surface roughness, pharmaceutical tablet, variable focus imaging},
  number       = {1},
  publisher    = {MDPI},
  title        = {{Electrically tunable lens (ETL) - based variable focus imaging system for parametric surface texture analysis of materials}},
  doi          = {10.3390/mi13010017},
  volume       = {13},
  year         = {2022},
}

@article{10587,
  abstract     = {Access to a blossoming library of colloidal nanomaterials provides building blocks for complex assembled materials. The journey to bring these prospects to fruition stands to benefit from the application of advanced processing methods. Epitaxially connected nanocrystal (or quantum dot) superlattices present a captivating model system for mesocrystals with intriguing emergent properties. The conventional processing approach to creating these materials involves assembling and attaching the constituent nanocrystals at the interface between two immiscible fluids. Processing small liquid volumes of the colloidal nanocrystal solution involves several complexities arising from the concurrent spreading, evaporation, assembly, and attachment. The ability of inkjet printers to deliver small (typically picoliter) liquid volumes with precise positioning is attractive to advance fundamental insights into the processing science, and thereby potentially enable new routes to incorporate the epitaxially connected superlattices into technology platforms. In this study, we identified the processing window of opportunity, including nanocrystal ink formulation and printing approach to enable delivery of colloidal nanocrystals from an inkjet nozzle onto the surface of a sessile droplet of the immiscible subphase. We demonstrate how inkjet printing can be scaled-down to enable the fabrication of epitaxially connected superlattices on patterned sub-millimeter droplets. We anticipate that insights from this work will spur on future advances to enable more mechanistic insights into the assembly processes and new avenues to create high-fidelity superlattices.},
  author       = {Balazs, Daniel and Erkan, N. Deniz and Quien, Michelle and Hanrath, Tobias},
  issn         = {1998-0000},
  journal      = {Nano Research},
  keywords     = {interfacial assembly, colloidal nanocrystal, superlattice, inkjet printing},
  number       = {5},
  pages        = {4536–4543},
  publisher    = {Springer Nature},
  title        = {{Inkjet printing of epitaxially connected nanocrystal superlattices}},
  doi          = {10.1007/s12274-021-4022-7},
  volume       = {15},
  year         = {2022},
}

@article{10588,
  abstract     = {We prove the Sobolev-to-Lipschitz property for metric measure spaces satisfying the quasi curvature-dimension condition recently introduced in Milman (Commun Pure Appl Math, to appear). We provide several applications to properties of the corresponding heat semigroup. In particular, under the additional assumption of infinitesimal Hilbertianity, we show the Varadhan short-time asymptotics for the heat semigroup with respect to the distance, and prove the irreducibility of the heat semigroup. These results apply in particular to large classes of (ideal) sub-Riemannian manifolds.},
  author       = {Dello Schiavo, Lorenzo and Suzuki, Kohei},
  issn         = {1432-1807},
  journal      = {Mathematische Annalen},
  keywords     = {quasi curvature-dimension condition, sub-riemannian geometry, Sobolev-to-Lipschitz property, Varadhan short-time asymptotics},
  pages        = {1815--1832},
  publisher    = {Springer Nature},
  title        = {{Sobolev-to-Lipschitz property on QCD- spaces and applications}},
  doi          = {10.1007/s00208-021-02331-2},
  volume       = {384},
  year         = {2022},
}

@article{10589,
  abstract     = {Superconducting devices ubiquitously have an excess of broken Cooper pairs, which can hamper their performance. It is widely believed that external radiation is responsible but a study now suggests there must be an additional, unknown source.},
  author       = {Higginbotham, Andrew P},
  issn         = {1745-2481},
  journal      = {Nature Physics},
  keywords     = {superconducting devices, superconducting properties and materials},
  pages        = {126},
  publisher    = {Springer Nature},
  title        = {{A secret source}},
  doi          = {10.1038/s41567-021-01459-x},
  volume       = {18},
  year         = {2022},
}

@article{10600,
  abstract     = {We show that recent results on adiabatic theory for interacting gapped many-body systems on finite lattices remain valid in the thermodynamic limit. More precisely, we prove a generalized super-adiabatic theorem for the automorphism group describing the infinite volume dynamics on the quasi-local algebra of observables. The key assumption is the existence of a sequence of gapped finite volume Hamiltonians, which generates the same infinite volume dynamics in the thermodynamic limit. Our adiabatic theorem also holds for certain perturbations of gapped ground states that close the spectral gap (so it is also an adiabatic theorem for resonances and, in this sense, “generalized”), and it provides an adiabatic approximation to all orders in the adiabatic parameter (a property often called “super-adiabatic”). In addition to the existing results for finite lattices, we also perform a resummation of the adiabatic expansion and allow for observables that are not strictly local. Finally, as an application, we prove the validity of linear and higher order response theory for our class of perturbations for infinite systems. While we consider the result and its proof as new and interesting in itself, we also lay the foundation for the proof of an adiabatic theorem for systems with a gap only in the bulk, which will be presented in a follow-up article.},
  author       = {Henheik, Sven Joscha and Teufel, Stefan},
  issn         = {1089-7658},
  journal      = {Journal of Mathematical Physics},
  keywords     = {mathematical physics, statistical and nonlinear physics},
  number       = {1},
  publisher    = {AIP Publishing},
  title        = {{Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap}},
  doi          = {10.1063/5.0051632},
  volume       = {63},
  year         = {2022},
}

@article{10602,
  abstract     = {Transforming ω-automata into parity automata is traditionally done using appearance records. We present an efficient variant of this idea, tailored to Rabin automata, and several optimizations applicable to all appearance records. We compare the methods experimentally and show that our method produces significantly smaller automata than previous approaches.},
  author       = {Kretinsky, Jan and Meggendorfer, Tobias and Waldmann, Clara and Weininger, Maximilian},
  issn         = {1432-0525},
  journal      = {Acta Informatica},
  keywords     = {computer networks and communications, information systems, software},
  pages        = {585--618},
  publisher    = {Springer Nature},
  title        = {{Index appearance record with preorders}},
  doi          = {10.1007/s00236-021-00412-y},
  volume       = {59},
  year         = {2022},
}

@article{10604,
  abstract     = {Maternally inherited Wolbachia transinfections are being introduced into natural mosquito populations to reduce the transmission of dengue, Zika, and other arboviruses. Wolbachia-induced cytoplasmic incompatibility provides a frequency-dependent reproductive advantage to infected females that can spread transinfections within and among populations. However, because transinfections generally reduce host fitness, they tend to spread within populations only after their frequency exceeds a critical threshold. This produces bistability with stable equilibrium frequencies at both 0 and 1, analogous to the bistability produced by underdominance between alleles or karyotypes and by population dynamics under Allee effects. Here, we analyze how stochastic frequency variation produced by finite population size can facilitate the local spread of variants with bistable dynamics into areas where invasion is unexpected from deterministic models. Our exemplar is the establishment of wMel Wolbachia in the Aedes aegypti population of Pyramid Estates (PE), a small community in far north Queensland, Australia. In 2011, wMel was stably introduced into Gordonvale, separated from PE by barriers to A. aegypti dispersal. After nearly 6 years during which wMel was observed only at low frequencies in PE, corresponding to an apparent equilibrium between immigration and selection, wMel rose to fixation by 2018. Using analytic approximations and statistical analyses, we demonstrate that the observed fixation of wMel at PE is consistent with both stochastic transition past an unstable threshold frequency and deterministic transformation produced by steady immigration at a rate just above the threshold required for deterministic invasion. The indeterminacy results from a delicate balance of parameters needed to produce the delayed transition observed. Our analyses suggest that once Wolbachia transinfections are established locally through systematic introductions, stochastic “threshold crossing” is likely to only minimally enhance spatial spread, providing a local ratchet that slightly—but systematically—aids area-wide transformation of disease-vector populations in heterogeneous landscapes.},
  author       = {Turelli, Michael and Barton, Nicholas H},
  issn         = {2056-3744},
  journal      = {Evolution Letters},
  keywords     = {genetics, ecology, evolution, behavior and systematics},
  number       = {1},
  pages        = {92--105},
  publisher    = {Wiley},
  title        = {{Why did the Wolbachia transinfection cross the road? Drift, deterministic dynamics, and disease control}},
  doi          = {10.1002/evl3.270},
  volume       = {6},
  year         = {2022},
}

@article{10608,
  abstract     = {We consider infinite-dimensional properties in coarse geometry for hyperspaces consisting of finite subsets of metric spaces with the Hausdorff metric. We see that several infinite-dimensional properties are preserved by taking the hyperspace of subsets with at most n points. On the other hand, we prove that, if a metric space contains a sequence of long intervals coarsely, then its hyperspace of finite subsets is not coarsely embeddable into any uniformly convex Banach space. As a corollary, the hyperspace of finite subsets of the real line is not coarsely embeddable into any uniformly convex Banach space. It is also shown that every (not necessarily bounded geometry) metric space with straight finite decomposition complexity has metric sparsification property.},
  author       = {Weighill, Thomas and Yamauchi, Takamitsu and Zava, Nicolò},
  issn         = {2199-6768},
  journal      = {European Journal of Mathematics},
  number       = {1},
  pages        = {335--355},
  publisher    = {Springer Nature},
  title        = {{Coarse infinite-dimensionality of hyperspaces of finite subsets}},
  doi          = {10.1007/s40879-021-00515-3},
  volume       = {8},
  year         = {2022},
}

@article{10639,
  abstract     = {With more than 80 members worldwide, the Orthobunyavirus genus in the Peribunyaviridae family is a large genus of enveloped RNA viruses, many of which are emerging pathogens in humans and livestock. How orthobunyaviruses (OBVs) penetrate and infect mammalian host cells remains poorly characterized. Here, we investigated the entry mechanisms of the OBV Germiston (GERV). Viral particles were visualized by cryo-electron microscopy and appeared roughly spherical with an average diameter of 98 nm. Labeling of the virus with fluorescent dyes did not adversely affect its infectivity and allowed the monitoring of single particles in fixed and live cells. Using this approach, we found that endocytic internalization of bound viruses was asynchronous and occurred within 30-40 min. The virus entered Rab5a+ early endosomes and, subsequently, late endosomal vacuoles containing Rab7a but not LAMP-1. Infectious entry did not require proteolytic cleavage, and endosomal acidification was sufficient and necessary for viral fusion. Acid-activated penetration began 15-25 min after initiation of virus internalization and relied on maturation of early endosomes to late endosomes. The optimal pH for viral membrane fusion was slightly below 6.0, and penetration was hampered when the potassium influx was abolished. Overall, our study provides real-time visualization of GERV entry into host cells and demonstrates the importance of late endosomal maturation in facilitating OBV penetration.},
  author       = {Windhaber, Stefan and Xin, Qilin and Uckeley, Zina M. and Koch, Jana and Obr, Martin and Garnier, Céline and Luengo-Guyonnot, Catherine and Duboeuf, Maëva and Schur, Florian KM and Lozach, Pierre-Yves},
  issn         = {1098-5514},
  journal      = {Journal of Virology},
  keywords     = {virology, insect science, immunology, microbiology},
  number       = {5},
  publisher    = {American Society for Microbiology},
  title        = {{The Orthobunyavirus Germiston enters host cells from late endosomes}},
  doi          = {10.1128/jvi.02146-21},
  volume       = {96},
  year         = {2022},
}

@article{10643,
  abstract     = {We prove a generalised super-adiabatic theorem for extended fermionic systems assuming a spectral gap only in the bulk. More precisely, we assume that the infinite system has a unique ground state and that the corresponding Gelfand–Naimark–Segal Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that a similar adiabatic theorem also holds in the bulk of finite systems up to errors that vanish faster than any inverse power of the system size, although the corresponding finite-volume Hamiltonians need not have a spectral gap.

},
  author       = {Henheik, Sven Joscha and Teufel, Stefan},
  issn         = {2050-5094},
  journal      = {Forum of Mathematics, Sigma},
  keywords     = {computational mathematics, discrete mathematics and combinatorics, geometry and topology, mathematical physics, statistics and probability, algebra and number theory, theoretical computer science, analysis},
  publisher    = {Cambridge University Press},
  title        = {{Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk}},
  doi          = {10.1017/fms.2021.80},
  volume       = {10},
  year         = {2022},
}

@article{10653,
  abstract     = {Squall lines are known to be the consequence of the interaction of low-level shear with cold pools associated with convective downdrafts. Also, as the magnitude of the shear increases beyond a critical shear, squall lines tend to orient themselves. The existing literature suggests that this orientation reduces incoming wind shear to the squall line, and maintains equilibrium between wind shear and cold pool spreading. Although this theory is widely accepted, very few quantitative studies have been conducted on supercritical regime especially. Here, we test this hypothesis with tropical squall lines obtained by imposing a vertical wind shear in cloud resolving simulations in radiative convective equilibrium. In the sub-critical regime, squall lines are perpendicular to the shear. In the super-critical regime, their orientation maintain the equilibrium, supporting existing theories. We also find that as shear increases, cold pools become more intense. However, this intensification has little impact on squall line orientation.},
  author       = {Abramian, Sophie and Muller, Caroline J and Risi, Camille},
  issn         = {1944-8007},
  journal      = {Geophysical Research Letters},
  number       = {1},
  publisher    = {Wiley},
  title        = {{Shear-convection interactions and orientation of tropical squall lines}},
  doi          = {10.1029/2021GL095184},
  volume       = {49},
  year         = {2022},
}

@article{10654,
  abstract     = {Directed percolation (DP) has recently emerged as a possible solution to the century old puzzle surrounding the transition to turbulence. Multiple model studies reported DP exponents, however, experimental evidence is limited since the largest possible observation times are orders of magnitude shorter than the flows’ characteristic timescales. An exception is cylindrical Couette flow where the limit is not temporal, but rather the realizable system size. We present experiments in a Couette setup of unprecedented azimuthal and axial aspect ratios. Approaching the critical point to within less than 0.1% we determine five critical exponents, all of which are in excellent agreement with the 2+1D DP universality class. The complex dynamics encountered at 
the onset of turbulence can hence be fully rationalized within the framework of statistical mechanics.},
  author       = {Klotz, Lukasz and Lemoult, Grégoire M and Avila, Kerstin and Hof, Björn},
  issn         = {1079-7114},
  journal      = {Physical Review Letters},
  number       = {1},
  publisher    = {American Physical Society},
  title        = {{Phase transition to turbulence in spatially extended shear flows}},
  doi          = {10.1103/PhysRevLett.128.014502},
  volume       = {128},
  year         = {2022},
}

@article{10658,
  abstract     = {We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’.},
  author       = {Sachdeva, Himani and Olusanya, Oluwafunmilola O and Barton, Nicholas H},
  issn         = {1471-2970},
  journal      = {Philosophical Transactions of the Royal Society B},
  number       = {1846},
  publisher    = {The Royal Society},
  title        = {{Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity}},
  doi          = {10.1098/rstb.2021.0010},
  volume       = {377},
  year         = {2022},
}

@article{10702,
  abstract     = {Background: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm predictor explains ~4% of the variance, independently of a polygenic score, in two external cohorts. It also associates with circulating levels of neurology- and inflammation-related proteins, global brain imaging metrics, and regional cortical volumes. Conclusions: As sample sizes increase, the ability to assess cognitive function from DNAm data may be informative in settings where cognitive testing is unreliable or unavailable.},
  author       = {McCartney, Daniel L. and Hillary, Robert F. and Conole, Eleanor L.S. and Banos, Daniel Trejo and Gadd, Danni A. and Walker, Rosie M. and Nangle, Cliff and Flaig, Robin and Campbell, Archie and Murray, Alison D. and Maniega, Susana Muñoz and Valdés-Hernández, María Del C. and Harris, Mathew A. and Bastin, Mark E. and Wardlaw, Joanna M. and Harris, Sarah E. and Porteous, David J. and Tucker-Drob, Elliot M. and McIntosh, Andrew M. and Evans, Kathryn L. and Deary, Ian J. and Cox, Simon R. and Robinson, Matthew Richard and Marioni, Riccardo E.},
  issn         = {1474-760X},
  journal      = {Genome Biology},
  number       = {1},
  publisher    = {Springer Nature},
  title        = {{Blood-based epigenome-wide analyses of cognitive abilities}},
  doi          = {10.1186/s13059-021-02596-5},
  volume       = {23},
  year         = {2022},
}

@article{10704,
  abstract     = {We define and study the existence of very stable Higgs bundles on Riemann surfaces, how it implies a precise formula for the multiplicity of the very stable components of the global nilpotent cone and its relationship to mirror symmetry. The main ingredients are the Bialynicki-Birula theory of C∗-actions on semiprojective varieties, C∗ characters of indices of C∗-equivariant coherent sheaves, Hecke transformation for Higgs bundles, relative Fourier–Mukai transform along the Hitchin fibration, hyperholomorphic structures on universal bundles and cominuscule Higgs bundles.},
  author       = {Hausel, Tamás and Hitchin, Nigel},
  issn         = {1432-1297},
  journal      = {Inventiones Mathematicae},
  pages        = {893--989},
  publisher    = {Springer Nature},
  title        = {{Very stable Higgs bundles, equivariant multiplicity and mirror symmetry}},
  doi          = {10.1007/s00222-021-01093-7},
  volume       = {228},
  year         = {2022},
}

@article{10705,
  abstract     = {Although rigidity and jamming transitions have been widely studied in physics and material science, their importance in a number of biological processes, including embryo development, tissue homeostasis, wound healing, and disease progression, has only begun to be recognized in the past few years. The hypothesis that biological systems can undergo rigidity/jamming transitions is attractive, as it would allow these systems to change their material properties rapidly and strongly. However, whether such transitions indeed occur in biological systems, how they are being regulated, and what their physiological relevance might be, is still being debated. Here, we review theoretical and experimental advances from the past few years, focusing on the regulation and role of potential tissue rigidity transitions in different biological processes.},
  author       = {Hannezo, Edouard B and Heisenberg, Carl-Philipp J},
  issn         = {1879-3088},
  journal      = {Trends in Cell Biology},
  number       = {5},
  pages        = {P433--444},
  publisher    = {Cell Press},
  title        = {{Rigidity transitions in development and disease}},
  doi          = {10.1016/j.tcb.2021.12.006},
  volume       = {32},
  year         = {2022},
}

@article{10706,
  abstract     = {This is a collection of problems composed by some participants of the workshop “Differential Geometry, Billiards, and Geometric Optics” that took place at CIRM on October 4–8, 2021.},
  author       = {Bialy, Misha and Fiorebe, Corentin and Glutsyuk, Alexey and Levi, Mark and Plakhov, Alexander and Tabachnikov, Serge},
  issn         = {2199-6806},
  journal      = {Arnold Mathematical Journal},
  location     = {Hybrid},
  pages        = {411--422},
  publisher    = {Springer Nature},
  title        = {{Open problems on billiards and geometric optics}},
  doi          = {10.1007/s40598-022-00198-y},
  volume       = {8},
  year         = {2022},
}

@article{10712,
  abstract     = {Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1 enabled higher levels of metastasis in a mouse model. We identified an increased migratory potential in MFSD1-/- tumor cells which was mediated by increased focal adhesion turn-over, reduced stability of mature inactive β1 integrin, and the resulting increased integrin activation index. We show that MFSD1 promoted recycling to the cell surface of endocytosed inactive β1 integrin and thereby protected β1 integrin from proteolytic degradation; this led to dampening of the integrin activation index. Furthermore, down-regulation of MFSD1 expression was observed during early steps of tumorigenesis and higher MFSD1 expression levels correlate with a better cancer patient prognosis. In sum, we describe a requirement for endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.},
  author       = {Roblek, Marko and Bicher, Julia and van Gogh, Merel and György, Attila and Seeböck, Rita and Szulc, Bozena and Damme, Markus and Olczak, Mariusz and Borsig, Lubor and Siekhaus, Daria E},
  issn         = {2234-943X},
  journal      = {Frontiers in Oncology},
  publisher    = {Frontiers},
  title        = {{The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis}},
  doi          = {10.3389/fonc.2022.777634},
  volume       = {12},
  year         = {2022},
}

